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Volume 42(4); August 2018
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Reviews
Complications
Diagnosing Diabetic Neuropathy: Something Old, Something New
Ioannis N. Petropoulos, Georgios Ponirakis, Adnan Khan, Hamad Almuhannadi, Hoda Gad, Rayaz A. Malik
Diabetes Metab J. 2018;42(4):255-269.   Published online August 21, 2018
DOI: https://doi.org/10.4093/dmj.2018.0056
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  • 73 Web of Science
  • 74 Crossref
AbstractAbstract PDFPubReader   

There are potentially many ways of assessing diabetic peripheral neuropathy (DPN). However, they do not fulfill U.S. Food and Drug Administration (FDA) requirements in relation to their capacity to assess therapeutic benefit in clinical trials of DPN. Over the past several decades symptoms and signs, quantitative sensory and electrodiagnostic testing have been strongly endorsed, but have consistently failed as surrogate end points in clinical trials. Therefore, there is an unmet need for reliable biomarkers to capture the onset and progression and to facilitate drug discovery in DPN. Corneal confocal microscopy (CCM) is a non-invasive ophthalmic imaging modality for in vivo evaluation of sensory C-fibers. An increasing body of evidence from multiple centers worldwide suggests that CCM fulfills the FDA criteria as a surrogate endpoint of DPN.

Citations

Citations to this article as recorded by  
  • Painful Diabetic Neuropathy: The Need for New Approaches
    Andrea M. Yeung, Jingtong Huang, Kevin T. Nguyen, Nicole Y. Xu, Lorenzo T. Hughes, Brajesh K. Agrawal, Niels Ejskjaer, David C. Klonoff
    Journal of Diabetes Science and Technology.2024; 18(1): 159.     CrossRef
  • COMMENT ON: Diabetic peripheral neuropathy is associated with diabetic kidney disease and cardiovascular disease: The silesia diabetes-heart project
    Laksh Kumar, Syed Ali Arsal
    Current Problems in Cardiology.2024; 49(4): 102227.     CrossRef
  • Risk factors for peripheral artery disease and diabetic peripheral neuropathy among patients with type 2 diabetes
    Tian Chen, Shengjue Xiao, Zhengdong Chen, Yiqing Yang, Bingquan Yang, Naifeng Liu
    Diabetes Research and Clinical Practice.2024; 207: 111079.     CrossRef
  • Laser-Induced Graphene-Based Smart Insole to Measure Plantar Temperature
    Amith Khandakar, Md. Ahasan Atick Faisal, Muhammad E. H. Chowdhury, Mamun Bin Ibne Reaz, Sawal Hamid Md Ali, Mohd Ibrahim bin Shapiai Abd. Razak, Ahmad Ashrif A. Bakar, Sakib Mahmud, Rayaz A. Malik
    IEEE Sensors Journal.2024; 24(2): 1190.     CrossRef
  • Morphometry of the sural nerve in diabetic neuropathy: a systematic review
    Zhang Ludi, Matthias Yi Quan Liau, Bryan Song Jun Yong, Amanda Sze Yen Auyong, Quah Hui Ting Lynette, Samuel Jianjie Yeo, Khin Swee Elizabeth Tan, Sreenivasulu Reddy Mogali, Ramya Chandrasekaran, Vivek Perumal, Ranganath Vallabhajosyula
    Journal of Ultrasound.2024; 27(2): 225.     CrossRef
  • Understanding the Clinical Relationship Between Diabetic Retinopathy, Nephropathy, and Neuropathy: A Comprehensive Review
    Aditi Kulkarni, Archana R Thool, Sachin Daigavane
    Cureus.2024;[Epub]     CrossRef
  • Assessment of neuropathy subtypes in type 1 diabetes
    Pall Karlsson, Marie Balle Sjogaard, Karoline Schousboe, Hatice Isik Mizrak, Huda Kufaishi, Troels Staehelin Jensen, Jens Randel Nyengaard, Christian Stevns Hansen, Knud Bonnet Yderstræde, Christian Selmer Buhl
    BMJ Open Diabetes Research & Care.2024; 12(4): e004289.     CrossRef
  • Predictive Factors for Altered Quality of Life in Patients with Type 2 Diabetes Mellitus
    Oana Albai, Adina Braha, Bogdan Timar, Romulus Timar
    Journal of Clinical Medicine.2024; 13(15): 4389.     CrossRef
  • Development and validation of risk prediction model for diabetic neuropathy among diabetes mellitus patients at selected referral hospitals, in Amhara regional state Northwest Ethiopia, 2005–2021
    Negalgn Byadgie Gelaw, Achenef Asmamaw Muche, Adugnaw Zeleke Alem, Nebiyu Bekele Gebi, Yazachew Moges Chekol, Tigabu Kidie Tesfie, Tsion Mulat Tebeje, Jacopo Sabbatinelli
    PLOS ONE.2023; 18(8): e0276472.     CrossRef
  • Biomarkers in diabetic neuropathy
    Kaveri M. Adki, Yogesh A. Kulkarni
    Archives of Physiology and Biochemistry.2023; 129(2): 460.     CrossRef
  • Early detection and treatment device for diabetic foot neuropathy
    Hunduma Tolossa Kumsa, Lelisa Getaneh Abdisa, Lelisa Tesema Tolessa, Sosina Ayele Wubneh, Wadajo Feyisa Kusa, Shimelis Nigusu Hordofa, Hundessa Daba Nemomssa
    Irish Journal of Medical Science (1971 -).2023; 192(1): 143.     CrossRef
  • Differences in motor unit behavior during isometric contractions in patients with diabetic peripheral neuropathy at various disease severities
    Mateus André Favretto, Felipe Rettore Andreis, Sandra Cossul, Francesco Negro, Anderson Souza Oliveira, Jefferson Luiz Brum Marques
    Journal of Electromyography and Kinesiology.2023; 68: 102725.     CrossRef
  • Association of peripheral neuropathy with subclinical left ventricular dysfunction in patients with type 2 diabetes
    Yanyan Chen, Yi Wang, Ying Zhang, Mengying Li, Weiqing Zhang, Yingni Zhou, Xiangyang Liu, Jianfang Fu, Zuowei Lu, Qian Xu, Tao Liu, Zeping Li, Xiaomiao Li, Jie Zhou
    Journal of Diabetes and its Complications.2023; 37(2): 108406.     CrossRef
  • Quantifying gait intralimb coordination patterns in individuals with different levels of diabetic neuropathy: a vector coding analysis
    Michelle Bazilio Milan, Guilherme Augusto Gomes De Villa, Eneida Yuri Suda, Isabel de Camargo Neves Sacco, Marcus Fraga Vieira
    Research on Biomedical Engineering.2023; 39(1): 311.     CrossRef
  • Mechanisms underlying altered neuromuscular function in people with DPN
    Antonin Le Corre, Nathan Caron, Nicolas A. Turpin, Georges Dalleau
    European Journal of Applied Physiology.2023; 123(7): 1433.     CrossRef
  • Peripheral Neuropathy in Diabetes Mellitus: Pathogenetic Mechanisms and Diagnostic Options
    Raffaele Galiero, Alfredo Caturano, Erica Vetrano, Domenico Beccia, Chiara Brin, Maria Alfano, Jessica Di Salvo, Raffaella Epifani, Alessia Piacevole, Giuseppina Tagliaferri, Maria Rocco, Ilaria Iadicicco, Giovanni Docimo, Luca Rinaldi, Celestino Sardu, T
    International Journal of Molecular Sciences.2023; 24(4): 3554.     CrossRef
  • Nerve conduction velocity is independently associated with bone mineral density in type 2 diabetes mellitus
    Xiao-jing Chen, Xiao-feng Wang, Zheng-can Pan, Deng Zhang, Ke-cheng Zhu, Tao Jiang, Xiao-ke Kong, Rui Xie, Li-hao Sun, Bei Tao, Jian-min Liu, Hong-yan Zhao
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Precision of Michigan Neuropathy Screening Instrument (MNSI) Tool for the Diagnosis of Diabetic Peripheral Neuropathy Among People with Type 2 Diabetes—A Study from South India
    Vijay Viswanathan, Balkhiwala Ahmed Khan, Sukanya Nachimuthu, Satyavani Kumpatla
    The International Journal of Lower Extremity Wounds.2023;[Epub]     CrossRef
  • Ankle Fractures in Diabetic Patients
    Ellen M. Goldberg, William S. Polachek, Kelly Hynes
    JBJS Reviews.2023;[Epub]     CrossRef
  • Comparing the Ipswich Touch Test (IpTT) and 10gm-SMWF (10-gm Semmes–Weinstein mono-filament) in Indian population subset with type 2 diabetes mellitus to detect diabetes neuropathy
    Sivasubramaniyam Senthilkumar, Ramesh Dasarathan, Pushkar Pazhani, Archana Gaur, Varatharajan Sakthivadivel
    Irish Journal of Medical Science (1971 -).2023; 192(6): 2793.     CrossRef
  • Diabetic neuropathy: Pathogenesis and evolving principles of management
    Basem Zaino, Rashika Goel, Sanjana Devaragudi, Ananya Prakash, Yogeshkumar Vaghamashi, Yashendra Sethi, Neil Patel, Nirja Kaka
    Disease-a-Month.2023; 69(9): 101582.     CrossRef
  • Association between Diabetic Peripheral Neuropathy as Measured Using a Point-of-Care Sural Nerve Conduction Device and Urinary Albumin Excretion in Patients with Type 2 Diabetes
    Tatsuya Fukuda, Akiko Fujii, Taro Akihisa, Naoya Otsubo, Masanori Murakami, Tetsuya Yamada, Chisato Maki
    Journal of Clinical Medicine.2023; 12(12): 4089.     CrossRef
  • Sudomotor dysfunction in diabetic peripheral neuropathy (DPN) and its testing modalities: A literature review
    Muhammad Akbar, Alvian Wandy, Gita Vita Soraya, Yudy Goysal, Mimi Lotisna, Muhammad Iqbal Basri
    Heliyon.2023; 9(7): e18184.     CrossRef
  • Novel insights into the nervous system affected by prolonged hyperglycemia
    Kamila Zglejc-Waszak, Konark Mukherjee, Agnieszka Korytko, Bogdan Lewczuk, Andrzej Pomianowski, Joanna Wojtkiewicz, Marta Banach, Michał Załęcki, Natalia Nowicka, Julia Jarosławska, Bernard Kordas, Krzysztof Wąsowicz, Judyta K. Juranek
    Journal of Molecular Medicine.2023; 101(8): 1015.     CrossRef
  • (Pre)diabetes and a higher level of glycaemic measures are continuously associated with corneal neurodegeneration assessed by corneal confocal microscopy: the Maastricht Study
    Sara B. A. Mokhtar, Frank C. T. van der Heide, Karel A. M. Oyaert, Carla J. H. van der Kallen, Tos T. J. M. Berendschot, Fabio Scarpa, Alessia Colonna, Bastiaan E. de Galan, Marleen M. J. van Greevenbroek, Pieter C. Dagnelie, Casper G. Schalkwijk, Rudy M.
    Diabetologia.2023; 66(11): 2030.     CrossRef
  • Potential Retinal Biomarkers in Alzheimer’s Disease
    Mariana Yolotzin García-Bermúdez, Rupali Vohra, Kristine Freude, Peter van Wijngaarden, Keith Martin, Maj Schneider Thomsen, Blanca Irene Aldana, Miriam Kolko
    International Journal of Molecular Sciences.2023; 24(21): 15834.     CrossRef
  • The effect of polyneuropathy severity on nerve conduction and pain syndrome in patients with type 2 diabetes
    A.Ya. Sabovchyk, M.M. Oros
    INTERNATIONAL NEUROLOGICAL JOURNAL.2023; 19(6): 161.     CrossRef
  • Artificial intelligence utilising corneal confocal microscopy for the diagnosis of peripheral neuropathy in diabetes mellitus and prediabetes
    Frank G. Preston, Yanda Meng, Jamie Burgess, Maryam Ferdousi, Shazli Azmi, Ioannis N. Petropoulos, Stephen Kaye, Rayaz A. Malik, Yalin Zheng, Uazman Alam
    Diabetologia.2022; 65(3): 457.     CrossRef
  • 10.6-μm infrared laser as adjuvant therapy for diabetic peripheral neuropathy: study protocol for a double-blind, randomized controlled trial
    Lin Lin, Yi Chen, Yuxia Li, Ke Cheng, Haiping Deng, Jianping Lu, Ling Zhao, Xueyong Shen
    Trials.2022;[Epub]     CrossRef
  • Diabetic corneal neuropathy as a surrogate marker for diabetic peripheral neuropathy
    WeiZheng So, NatalieShi Qi Wong, HongChang Tan, MollyTzu Yu Lin, IsabelleXin Yu Lee, JodhbirS Mehta, Yu-Chi Liu
    Neural Regeneration Research.2022; 17(10): 2172.     CrossRef
  • SUDOSCAN in Combination with the Michigan Neuropathy Screening Instrument Is an Effective Tool for Screening Diabetic Peripheral Neuropathy
    Tae Jung Oh, Yoojung Song, Hak Chul Jang, Sung Hee Choi
    Diabetes & Metabolism Journal.2022; 46(2): 319.     CrossRef
  • Performance Analysis of Conventional Machine Learning Algorithms for Diabetic Sensorimotor Polyneuropathy Severity Classification Using Nerve Conduction Studies
    Fahmida Haque, Mamun B. I. Reaz, Muhammad E. H. Chowdhury, Serkan Kiranyaz, Sawal H. M. Ali, Mohammed Alhatou, Rumana Habib, Ahmad A. A. Bakar, Norhana Arsad, Geetika Srivastava, Paolo Crippa
    Computational Intelligence and Neuroscience.2022; 2022: 1.     CrossRef
  • The Presence of Clonal Hematopoiesis Is Negatively Associated with Diabetic Peripheral Neuropathy in Type 2 Diabetes
    Tae Jung Oh, Han Song, Youngil Koh, Sung Hee Choi
    Endocrinology and Metabolism.2022; 37(2): 243.     CrossRef
  • An overview of painful diabetic peripheral neuropathy: Diagnosis and treatment advancements
    Jonathan M. Hagedorn, Alyson M. Engle, Tony K. George, Jay Karri, Newaj Abdullah, Erik Ovrom, Jhon E. Bocanegra-Becerra, Ryan S. D'Souza
    Diabetes Research and Clinical Practice.2022; 188: 109928.     CrossRef
  • Prevalence and risk of diabetic complications in young-onset versus late-onset type 2 diabetes mellitus
    Yongin Cho, Hye-Sun Park, Byung Wook Huh, Seong Ha Seo, Da Hea Seo, Seong Hee Ahn, Seongbin Hong, Young Ju Suh, So Hun Kim
    Diabetes & Metabolism.2022; 48(6): 101389.     CrossRef
  • Artificial Intelligence and Corneal Confocal Microscopy: The Start of a Beautiful Relationship
    Uazman Alam, Matthew Anson, Yanda Meng, Frank Preston, Varo Kirthi, Timothy L. Jackson, Paul Nderitu, Daniel J. Cuthbertson, Rayaz A. Malik, Yalin Zheng, Ioannis N. Petropoulos
    Journal of Clinical Medicine.2022; 11(20): 6199.     CrossRef
  • INvesTigating the Abnormality of detrusor ConTractility by uroflowmetry in diabetic children (INTACT Trial): protocol of a prospective, observational study
    Ágnes Rita Martonosi, Piroska Pázmány, Szabolcs Kiss, Annamária Zsákai, László Szabó
    BMJ Open.2022; 12(11): e062198.     CrossRef
  • Diabetic foot ulcers: A devastating complication of diabetes mellitus continues non-stop in spite of new medical treatment modalities
    Gamze Akkus, Murat Sert
    World Journal of Diabetes.2022; 13(12): 1106.     CrossRef
  • Corneal nerves in diabetes—The role of the in vivo corneal confocal microscopy of the subbasal nerve plexus in the assessment of peripheral small fiber neuropathy
    Anna M. Roszkowska, Carmelo Licitra, Giuseppe Tumminello, Elisa I. Postorino, Michele R. Colonna, Pasquale Aragona
    Survey of Ophthalmology.2021; 66(3): 493.     CrossRef
  • Association between Sleep Quality and Painless Diabetic Peripheral Neuropathy Assessed by Current Perception Threshold in Type 2 Diabetes Mellitus
    Dughyun Choi, Bo-Yeon Kim, Chan-Hee Jung, Chul-Hee Kim, Ji-Oh Mok
    Diabetes & Metabolism Journal.2021; 45(3): 358.     CrossRef
  • Glycaemic control for painful diabetic peripheral neuropathy is more than fasting plasma glucose and glycated haemoglobin
    Y.-W. Pai, C.-L. Tang, C.-H. Lin, S.-Y. Lin, I.-T. Lee, M.-H. Chang
    Diabetes & Metabolism.2021; 47(1): 101158.     CrossRef
  • Diagnosis of Neuropathy and Risk Factors for Corneal Nerve Loss in Type 1 and Type 2 Diabetes: A Corneal Confocal Microscopy Study
    Maryam Ferdousi, Alise Kalteniece, Shazli Azmi, Ioannis N. Petropoulos, Georgios Ponirakis, Uazman Alam, Omar Asghar, Andrew Marshall, Catherine Fullwood, Maria Jeziorska, Caroline Abbott, Giuseppe Lauria, Catharina G. Faber, Handrean Soran, Nathan Efron,
    Diabetes Care.2021; 44(1): 150.     CrossRef
  • Widespread sensory neuropathy in diabetic patients hospitalized with severe COVID-19 infection
    Ariel Odriozola, Lucía Ortega, Lidia Martinez, Samantha Odriozola, Ainhoa Torrens, David Corroleu, Silvia Martínez, Meritxell Ponce, Yolanda Meije, Mercedes Presas, Alejandra Duarte, M. Belén Odriozola, Rayaz A. Malik
    Diabetes Research and Clinical Practice.2021; 172: 108631.     CrossRef
  • Lost in Translation? Measuring Diabetic Neuropathy in Humans and Animals
    Heung Yong Jin, Seong-Su Moon, Nigel A. Calcutt
    Diabetes & Metabolism Journal.2021; 45(1): 27.     CrossRef
  • Early Detection of Diabetic Peripheral Neuropathy: A Focus on Small Nerve Fibres
    Jamie Burgess, Bernhard Frank, Andrew Marshall, Rashaad S. Khalil, Georgios Ponirakis, Ioannis N. Petropoulos, Daniel J. Cuthbertson, Rayaz A. Malik, Uazman Alam
    Diagnostics.2021; 11(2): 165.     CrossRef
  • Role of interdigital sensory nerve conduction study as a noninvasive approach for early diagnosis of diabetic peripheral neuropathy
    Hamid R. Fateh, Seyed Pezhman Madani
    Journal of Diabetes & Metabolic Disorders.2021; 20(1): 71.     CrossRef
  • Performance Analysis of Conventional Machine Learning Algorithms for Diabetic Sensorimotor Polyneuropathy Severity Classification
    Fahmida Haque, Mamun Bin Ibne Reaz, Muhammad Enamul Hoque Chowdhury, Geetika Srivastava, Sawal Hamid Md Ali, Ahmad Ashrif A. Bakar, Mohammad Arif Sobhan Bhuiyan
    Diagnostics.2021; 11(5): 801.     CrossRef
  • Advances in Screening, Early Diagnosis and Accurate Staging of Diabetic Neuropathy
    Josie Carmichael, Hassan Fadavi, Fukashi Ishibashi, Angela C. Shore, Mitra Tavakoli
    Frontiers in Endocrinology.2021;[Epub]     CrossRef
  • Vibration Perception Threshold and Related Factors for Balance Assessment in Patients with Type 2 Diabetes Mellitus
    Jisang Jung, Min-Gyu Kim, Youn-Joo Kang, Kyungwan Min, Kyung-Ah Han, Hyoseon Choi
    International Journal of Environmental Research and Public Health.2021; 18(11): 6046.     CrossRef
  • Diabetic Peripheral Neuropathy Affects Pinch Strength and Hand Dexterity in Elderly Patients
    Qi Zhang, Yifang Lin, Xinhua Liu, Li Zhang, Yan Zhang, Dong Zhao, Qi Lu, Jie Jia, Jia-Jia Wu
    Neural Plasticity.2021; 2021: 1.     CrossRef
  • Association of Combined TCF7L2 and KCNQ1 Gene Polymorphisms with Diabetic Micro- and Macrovascular Complications in Type 2 Diabetes Mellitus
    Rujikorn Rattanatham, Nongnuch Settasatian, Nantarat Komanasin, Upa Kukongviriyapan, Kittisak Sawanyawisuth, Phongsak Intharaphet, Vichai Senthong, Chatri Settasatian
    Diabetes & Metabolism Journal.2021; 45(4): 578.     CrossRef
  • Neuropeptide Y: a potential theranostic biomarker for diabetic peripheral neuropathy in patients with type-2 diabetes
    Noo Ree Cho, Yeuni Yu, Chang-Kyu Oh, Dai Sik Ko, Kyungjae Myung, Yoonsung Lee, Hee Sam Na, Yun Hak Kim
    Therapeutic Advances in Chronic Disease.2021;[Epub]     CrossRef
  • Prediction of Diabetic Sensorimotor Polyneuropathy Using Machine Learning Techniques
    Dae Youp Shin, Bora Lee, Won Sang Yoo, Joo Won Park, Jung Keun Hyun
    Journal of Clinical Medicine.2021; 10(19): 4576.     CrossRef
  • Reduced association between dendritic cells and corneal sub‐basal nerve fibers in patients with fibromyalgia syndrome
    Alexander Klitsch, Dimitar Evdokimov, Johanna Frank, Dominique Thomas, Nadine Saffer, Caren Meyer zu Altenschildesche, Marco Sisignano, Daniel Kampik, Rayaz A. Malik, Claudia Sommer, Nurcan Üçeyler
    Journal of the Peripheral Nervous System.2020; 25(1): 9.     CrossRef
  • Diet-Induced Rodent Models of Diabetic Peripheral Neuropathy, Retinopathy and Nephropathy
    Inês Preguiça, André Alves, Sara Nunes, Pedro Gomes, Rosa Fernandes, Sofia D. Viana, Flávio Reis
    Nutrients.2020; 12(1): 250.     CrossRef
  • Diabetic Distal Symmetrical Polyneuropathy: Correlation of Clinical, Laboratory, and Electrophysiologic Studies in Patients with Type 2 Diabetes Mellitus
    Yi-Ching Weng, Sung-Sheng Tsai, Rong-Kuo Lyu, Chun-Che Chu, Long-Sun Ro, Ming-Feng Liao, Hong-Shiu Chang, Chiung-Mei Chen, Jawl-Shan Hwang, Hung-Chou Kuo
    Journal of Diabetes Research.2020; 2020: 1.     CrossRef
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    Rizaldy T. Pinzon, M. Kes, Rosa De Lima R. Sa
    Asian Journal of Biological Sciences.2020; 13(2): 168.     CrossRef
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    Myung Haeng Hur, Mi-Kyoung Lee, Kayeon Seong, Jun Hwa Hong
    Diabetes & Metabolism Journal.2020; 44(5): 679.     CrossRef
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    Charles Faselis, Alexandra Katsimardou, Konstantinos Imprialos, Pavlos Deligkaris, Manolis Kallistratos, Kiriakos Dimitriadis
    Current Vascular Pharmacology.2020; 18(2): 117.     CrossRef
  • Computational methods for automated analysis of corneal nerve images: Lessons learned from retinal fundus image analysis
    Tooba Salahuddin, Uvais Qidwai
    Computers in Biology and Medicine.2020; 119: 103666.     CrossRef
  • TIR generated by continuous glucose monitoring is associated with peripheral nerve function in type 2 diabetes
    Fengwen Li, Yinan Zhang, Huizhi Li, Jingyi Lu, Lan Jiang, Robert A. Vigersky, Jian Zhou, Congrong Wang, Yuqian Bao, Weiping Jia
    Diabetes Research and Clinical Practice.2020; 166: 108289.     CrossRef
  • A Phase 2 Clinical Trial on the Use of Cibinetide for the Treatment of Diabetic Macular Edema
    Noemi Lois, Evie Gardner, Margaret McFarland, David Armstrong, Christine McNally, Nuala Jane Lavery, Christina Campbell, Rita I Kirk, Daiva Bajorunas, Ann Dunne, Anthony Cerami, Michael Brines
    Journal of Clinical Medicine.2020; 9(7): 2225.     CrossRef
  • Diabetic neuropathy and neuropathic pain: a (con)fusion of pathogenic mechanisms?
    Nigel A. Calcutt
    Pain.2020; 161(Supplement): S65.     CrossRef
  • Lumos for the long trail: Strategies for clinical diagnosis and severity staging for diabetic polyneuropathy and future directions
    Tatsuhito Himeno, Hideki Kamiya, Jiro Nakamura
    Journal of Diabetes Investigation.2020; 11(1): 5.     CrossRef
  • Corneal confocal microscopy detects small nerve fibre damage in patients with painful diabetic neuropathy
    Alise Kalteniece, Maryam Ferdousi, Shazli Azmi, Womba M. Mubita, Andrew Marshall, Giuseppe Lauria, Catharina G. Faber, Handrean Soran, Rayaz A. Malik
    Scientific Reports.2020;[Epub]     CrossRef
  • The Association of Fasting C-peptide with Corneal Neuropathy in Patients with Type 2 Diabetes
    Anju Zuo, Chuan Wang, Lili Li, Jingru Qu, Juan Cao, Li Chen, Solomon Tesfaye, Wenjuan Li, Xinguo Hou, Vincenza Spallone
    Journal of Diabetes Research.2020; 2020: 1.     CrossRef
  • Performance analysis of noninvasive electrophysiological methods for the assessment of diabetic sensorimotor polyneuropathy in clinical research: a systematic review and meta-analysis with trial sequential analysis
    Fahmida Haque, Mamun Bin Ibne Reaz, Sawal Hamid Md Ali, Norhana Arsad, Muhammad Enamul Hoque Chowdhury
    Scientific Reports.2020;[Epub]     CrossRef
  • Tear film substance P: A potential biomarker for diabetic peripheral neuropathy
    Shyam Sunder Tummanapalli, Mark D.P. Willcox, Tushar Issar, Aimy Yan, Jana Pisarcikova, Natalie Kwai, Ann M. Poynten, Arun V. Krishnan, Maria Markoulli
    The Ocular Surface.2019; 17(4): 690.     CrossRef
  • Characterizing distal peripheral neuropathy in type 2 diabetes mellitus in a semi-urban community setting in Peru
    Meera F Iyengar, Antonio Bernabe-Ortiz
    Journal of Global Health Reports.2019;[Epub]     CrossRef
  • Diabetic peripheral neuropathy: advances in diagnosis and strategies for screening and early intervention
    Dinesh Selvarajah, Debasish Kar, Kamlesh Khunti, Melanie J Davies, Adrian R Scott, Jeremy Walker, Solomon Tesfaye
    The Lancet Diabetes & Endocrinology.2019; 7(12): 938.     CrossRef
  • Diabetic Peripheral Neuropathy as a Risk Factor for Sarcopenia
    Tae Jung Oh, Yoojung Song, Jae Hoon Moon, Sung Hee Choi, Hak Chul Jang
    Annals of Geriatric Medicine and Research.2019; 23(4): 170.     CrossRef
  • Diabetic Neuropathy: New Insights to Early Diagnosis and Treatments
    Mark Yorek, Rayaz A. Malik, Nigel A. Calcutt, Aaron Vinik, Soroku Yagihashi
    Journal of Diabetes Research.2018; 2018: 1.     CrossRef
  • Use of parenteral vitamin B complexes in treatment of polyneuropathy
    O. V. Kurushina, A. E. Barulin, O. I. Agarkova
    Medical Council.2018; (18): 62.     CrossRef
  • Circulating microRNAs as biomarkers for diabetic neuropathy: A novel approach
    Eleni Xourgia, Athanasia Papazafiropoulou, Andreas Melidonis
    World Journal of Experimental Medicine.2018; 8(3): 18.     CrossRef
Obesity and Metabolic Syndrome
Role of the Pyruvate Dehydrogenase Complex in Metabolic Remodeling: Differential Pyruvate Dehydrogenase Complex Functions in Metabolism
Sungmi Park, Jae-Han Jeon, Byong-Keol Min, Chae-Myeong Ha, Themis Thoudam, Bo-Yoon Park, In-Kyu Lee
Diabetes Metab J. 2018;42(4):270-281.   Published online August 21, 2018
DOI: https://doi.org/10.4093/dmj.2018.0101
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AbstractAbstract PDFPubReader   

Mitochondrial dysfunction is a hallmark of metabolic diseases such as obesity, type 2 diabetes mellitus, neurodegenerative diseases, and cancers. Dysfunction occurs in part because of altered regulation of the mitochondrial pyruvate dehydrogenase complex (PDC), which acts as a central metabolic node that mediates pyruvate oxidation after glycolysis and fuels the Krebs cycle to meet energy demands. Fine-tuning of PDC activity has been mainly attributed to post-translational modifications of its subunits, including the extensively studied phosphorylation and de-phosphorylation of the E1α subunit of pyruvate dehydrogenase (PDH), modulated by kinases (pyruvate dehydrogenase kinase [PDK] 1-4) and phosphatases (pyruvate dehydrogenase phosphatase [PDP] 1-2), respectively. In addition to phosphorylation, other covalent modifications, including acetylation and succinylation, and changes in metabolite levels via metabolic pathways linked to utilization of glucose, fatty acids, and amino acids, have been identified. In this review, we will summarize the roles of PDC in diverse tissues and how regulation of its activity is affected in various metabolic disorders.

Citations

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    Sai Sanwid Pradhan, Sai Swaroop R., Sai Phalguna Kanikaram, Datta Darshan V.M., Ashish Pargaonkar, Rajesh Babu Dandamudi, Venketesh Sivaramakrishnan
    Journal of Biomolecular Structure and Dynamics.2024; 42(19): 10521.     CrossRef
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    Ricardo Amorim, Carina C. Magalhães, Sofia Benfeito, Fernando Cagide, Ludgero C. Tavares, Katia Santos, Vilma A. Sardão, Sandipan Datta, Gino A. Cortopassi, Inês Baldeiras, John G. Jones, Fernanda Borges, Paulo J. Oliveira, José Teixeira
    Biochemical Pharmacology.2024; 219: 115953.     CrossRef
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    Bioorganic & Medicinal Chemistry Letters.2024; 98: 129571.     CrossRef
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    ACS Pharmacology & Translational Science.2024; 7(1): 42.     CrossRef
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    Kuo Chi, Jing Liu, Xinghua Li, He Wang, Yanliang Li, Qingnan Liu, Yabin Zhou, Yuan Ge
    Molecular Omics.2024; 20(3): 169.     CrossRef
  • Upregulation of the AMPK-FOXO1-PDK4 pathway is a primary mechanism of pyruvate dehydrogenase activity reduction in tafazzin-deficient cells
    Zhuqing Liang, Tyler Ralph-Epps, Michael W. Schmidtke, Pablo Lazcano, Simone W. Denis, Mária Balážová, Nevton Teixeira da Rosa, Mohamed Chakkour, Sanaa Hazime, Mindong Ren, Michael Schlame, Riekelt H. Houtkooper, Miriam L. Greenberg
    Scientific Reports.2024;[Epub]     CrossRef
  • Redox remodeling of central metabolism as a driving force for cellular protection, proliferation, differentiation, and dysfunction
    Junichi Fujii
    Free Radical Research.2024; : 1.     CrossRef
  • Effects of ambient UVB light on Pacific oyster Crassostrea gigas mantle tissue based on multivariate data
    Hongce Song, Chaoyi Xie, Meiyun Dong, Yuxuan Zhang, Haifeng Huang, Yijing Han, Yaqiong Liu, Lei Wei, Xiaotong Wang
    Ecotoxicology and Environmental Safety.2024; 274: 116236.     CrossRef
  • Autocrine phosphatase PDP2 inhibits ferroptosis by dephosphorylating ACSL4 in the Luminal A Breast Cancer
    Jun-Jie Zhu, Feng-Ying Huang, Hengyu Chen, Yun-long Zhang, Ming-Hui Chen, Ri-Hong Wu, Shu-Zhen Dai, Gui-Sheng He, Guang-Hong Tan, Wu-Ping Zheng, Sreeparna Banerjee
    PLOS ONE.2024; 19(3): e0299571.     CrossRef
  • Glutaminase potentiates the glycolysis in esophageal squamous cell carcinoma by interacting with PDK1
    Guangzhao Zhu, Fangxia Guan, Shenglei Li, Qing Zhang, Xueying Zhang, Yue Qin, Zhangzhan Sun, Shaohua Peng, Jiexing Cheng, Yiyang Li, Ruili Ren, Tianli Fan, Hongtao Liu
    Molecular Carcinogenesis.2024; 63(5): 897.     CrossRef
  • In Vitro and In Silico Studies on Cytotoxic Properties of Oxythiamine and 2′-Methylthiamine
    Marta Malinowska, Magdalena Czerniecka, Izabella Jastrzebska, Artur Ratkiewicz, Adam Tylicki, Natalia Wawrusiewicz-Kurylonek
    International Journal of Molecular Sciences.2024; 25(8): 4359.     CrossRef
  • Protein lipoylation: mitochondria, cuproptosis, and beyond
    Cheng-Han Lin, Yeh Chin, Ming Zhou, Robert W. Sobol, Mien-Chie Hung, Ming Tan
    Trends in Biochemical Sciences.2024; 49(8): 729.     CrossRef
  • Cuproptosis-Related Genes as Prognostic Biomarkers for Sepsis: Insights into Immune Function and Personalized Immunotherapy
    Jun Zhang, Yinyu Wu, Yuanlin Du, Yunxia Du, Daiqin Bao, Haibin Lu, Xiaoqiong Zhou, Rui Li, Haoyu Pei, Han She, Qingxiang Mao
    Journal of Inflammation Research.2024; Volume 17: 4229.     CrossRef
  • ER calcium depletion as a key driver for impaired ER-to-mitochondria calcium transfer and mitochondrial dysfunction in Wolfram syndrome
    Mailis Liiv, Annika Vaarmann, Dzhamilja Safiulina, Vinay Choubey, Ruby Gupta, Malle Kuum, Lucia Janickova, Zuzana Hodurova, Michal Cagalinec, Akbar Zeb, Miriam A. Hickey, Yi-Long Huang, Nana Gogichaishvili, Merle Mandel, Mario Plaas, Eero Vasar, Jens Lonc
    Nature Communications.2024;[Epub]     CrossRef
  • PDK4-mediated metabolic reprogramming is a potential therapeutic target for neovascular age-related macular degeneration
    Juhee Kim, Yujin Jeon, Jinyoung Son, Haushabhau S. Pagire, Suvarna H. Pagire, Jin Hee Ahn, Akiyoshi Uemura, In-Kyu Lee, Sungmi Park, Dong Ho Park
    Cell Death & Disease.2024;[Epub]     CrossRef
  • Role of Exogenous Pyruvate in Maintaining Adenosine Triphosphate Production under High-Glucose Conditions through PARP-Dependent Glycolysis and PARP-Independent Tricarboxylic Acid Cycle
    Hideji Yako, Naoko Niimi, Shizuka Takaku, Ayako Kato, Koichi Kato, Kazunori Sango
    International Journal of Molecular Sciences.2024; 25(20): 11089.     CrossRef
  • DLAT promotes triple-negative breast cancer progression via YAP1 activation
    Diya Liu, Xuehui Wang, Fengyuan Qian, Danrong Ye, Xiaochong Deng, Lin Fang
    Cancer Biology & Therapy.2024;[Epub]     CrossRef
  • The role of cuproptosis in gastric cancer
    Yixian Li, Wenhao Sun, Shaolin Yuan, Xinxin Liu, Ziqi Zhang, Renjun Gu, Pengfei Li, Xin Gu
    Frontiers in Immunology.2024;[Epub]     CrossRef
  • Inhibition of Pyruvate Dehydrogenase Kinase 4 in CD4+ T Cells Ameliorates Intestinal Inflammation
    Hoyul Lee, Jae Han Jeon, Yu-Jeong Lee, Mi-Jin Kim, Woong Hee Kwon, Dipanjan Chanda, Themis Thoudam, Haushabhau S. Pagire, Suvarna H. Pagire, Jin Hee Ahn, Robert A. Harris, Eun Soo Kim, In-Kyu Lee
    Cellular and Molecular Gastroenterology and Hepatology.2023; 15(2): 439.     CrossRef
  • Nitric oxide regulation of cellular metabolism: Adaptive tuning of cellular energy
    Gregory Pappas, Melissa L. Wilkinson, Andrew J. Gow
    Nitric Oxide.2023; 131: 8.     CrossRef
  • Furan-based inhibitors of pyruvate dehydrogenase: SAR study, biochemical evaluation and computational analysis
    Alex H. Y. Chan, Terence C. S. Ho, Daniel R. Parle, Finian J. Leeper
    Organic & Biomolecular Chemistry.2023; 21(8): 1755.     CrossRef
  • The pyruvate dehydrogenase complex: Life’s essential, vulnerable and druggable energy homeostat
    Peter W. Stacpoole, Charles E. McCall
    Mitochondrion.2023; 70: 59.     CrossRef
  • The Impact of Krebs Cycle Intermediates on the Endocrine System and Immune System: A Comparison
    Borros M. Arneth
    Endocrines.2023; 4(1): 179.     CrossRef
  • Consequences of reprogramming acetyl-CoA metabolism by 2,3,7,8-tetrachlorodibenzo-p-dioxin in the mouse liver
    Giovan N. Cholico, Karina Orlowska, Russell R. Fling, Warren J. Sink, Nicholas A. Zacharewski, Kelly A. Fader, Rance Nault, Tim Zacharewski
    Scientific Reports.2023;[Epub]     CrossRef
  • The Link between Mitochondrial Dysfunction and Sarcopenia: An Update Focusing on the Role of Pyruvate Dehydrogenase Kinase 4
    Min-Ji Kim, Ibotombi Singh Sinam, Zerwa Siddique, Jae-Han Jeon, In-Kyu Lee
    Diabetes & Metabolism Journal.2023; 47(2): 153.     CrossRef
  • Targeting PDK2 rescues stress-induced impaired brain energy metabolism
    Changshui Wang, Changmeng Cui, Pengfei Xu, Li Zhu, Hongjia Xue, Beibei Chen, Pei Jiang
    Molecular Psychiatry.2023; 28(10): 4138.     CrossRef
  • The Role of Pyruvate Metabolism in Mitochondrial Quality Control and Inflammation
    Min-Ji Kim, Hoyul Lee, Dipanjan Chanda, Themis Thoudam, Hyeon-Ji Kang, Robert A. Harris, In-Kyu Lee
    Molecules and Cells.2023; 46(5): 259.     CrossRef
  • Inhibition of pyruvate dehydrogenase kinase 4 ameliorates kidney ischemia-reperfusion injury by reducing succinate accumulation during ischemia and preserving mitochondrial function during reperfusion
    Chang Joo Oh, Min-Ji Kim, Ji-Min Lee, Dong Hun Kim, Il-Young Kim, Sanghee Park, Yeongmin Kim, Kyung-Bok Lee, Sang-Hee Lee, Chae Won Lim, Myeongjin Kim, Jung-Yi Lee, Haushabhau S. Pagire, Suvarna H. Pagire, Myung Ae Bae, Dipanjan Chanda, Themis Thoudam, Ah
    Kidney International.2023; 104(4): 724.     CrossRef
  • PDHA1 hyperacetylation-mediated lactate overproduction promotes sepsis-induced acute kidney injury via Fis1 lactylation
    Sheng An, Yi Yao, Hongbin Hu, Junjie Wu, Jiaxin Li, Lulan Li, Jie Wu, Maomao Sun, Zhiya Deng, Yaoyuan Zhang, Shenhai Gong, Qiaobing Huang, Zhongqing Chen, Zhenhua Zeng
    Cell Death & Disease.2023;[Epub]     CrossRef
  • Iron promotes glycolysis to drive colon tumorigenesis
    Zhaoli Liu, Luke Villareal, Lavanya Goodla, Hyeoncheol Kim, Daniel M. Falcon, Mohammad Haneef, David R. Martin, Li Zhang, Ho-Joon Lee, Daniel Kremer, Costas A. Lyssiotis, Yatrik M. Shah, Henry C. Lin, Hui-kuan Lin, Xiang Xue
    Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2023; 1869(8): 166846.     CrossRef
  • Driving force of deteriorated cellular environment in heart failure: Metabolic remodeling
    Lu Fan, Chenchen Meng, Xiaoming Wang, Yunjiao Wang, Yanyang Li, Shichao Lv, Junping Zhang
    Clinics.2023; 78: 100263.     CrossRef
  • Mitochondrial dysfunctions in T cells: focus on inflammatory bowel disease
    Hoyul Lee, Jae-Han Jeon, Eun Soo Kim
    Frontiers in Immunology.2023;[Epub]     CrossRef
  • Adrenomedullin induces cisplatin chemoresistance in ovarian cancer through reprogramming of glucose metabolism
    Lei Dou, Enting Lu, Dongli Tian, Fangmei Li, Lei Deng, Yi Zhang
    Journal of Translational Internal Medicine.2023; 11(2): 169.     CrossRef
  • Unique and generic crossed metabolism in response to four sub-lethal environmental stresses in the oriental fruit fly, Bactrocera dorsalis Hendel
    Lili Ren, Hongxia Zhang, Jiao Zhou, Yajing Wu, Bo Liu, Shuping Wang, Xin Liu, Xin Hao, Lilin Zhao
    Ecotoxicology and Environmental Safety.2023; 264: 115434.     CrossRef
  • Oxidative stress regulation and related metabolic pathways in epithelial–mesenchymal transition of breast cancer stem cells
    Raheleh Farahzadi, Behnaz Valipour, Ezzatollah Fathi, Samaneh Pirmoradi, Ommoleila Molavi, Soheila Montazersaheb, Zohreh Sanaat
    Stem Cell Research & Therapy.2023;[Epub]     CrossRef
  • Preclinical Study in Mouse Thymus and Thymocytes: Effects of Treatment with a Combination of Sodium Dichloroacetate and Sodium Valproate on Infectious Inflammation Pathways
    Donatas Stakišaitis, Linas Kapočius, Evelina Kilimaitė, Dovydas Gečys, Lina Šlekienė, Ingrida Balnytė, Jolita Palubinskienė, Vaiva Lesauskaitė
    Pharmaceutics.2023; 15(12): 2715.     CrossRef
  • Contrasting effects of whole-body and hepatocyte-specific deletion of the RNA polymerase III repressor Maf1 in the mouse
    Gilles Willemin, François Mange, Viviane Praz, Séverine Lorrain, Pascal Cousin, Catherine Roger, Ian M. Willis, Nouria Hernandez
    Frontiers in Molecular Biosciences.2023;[Epub]     CrossRef
  • Reprogramming of glucose metabolism of cumulus cells and oocytes and its therapeutic significance
    Shogo Imanaka, Hiroshi Shigetomi, Hiroshi Kobayashi
    Reproductive Sciences.2022; 29(3): 653.     CrossRef
  • Renal denervation ameliorates cardiac metabolic remodeling in diabetic cardiomyopathy rats by suppressing renal SGLT2 expression
    Jun-Yu Huo, Wan-Ying Jiang, Shi-Geng Zhang, Yi-Ting Lyu, Jie Geng, Meng Chen, Yuan-Yuan Chen, Zhi-Xin Jiang, Qi-Jun Shan
    Laboratory Investigation.2022; 102(4): 341.     CrossRef
  • Alteration in glycolytic/cholesterogenic gene expression is associated with bladder cancer prognosis and immune cell infiltration
    Yuying Zhang, Baoyi Zhu, Yi Cai, Sihua Zhu, Hongjun Zhao, Xiaoling Ying, Chonghe Jiang, Jianwen Zeng
    BMC Cancer.2022;[Epub]     CrossRef
  • Protein phosphorylation in hemocytes of Fenneropenaeus chinensis in response to white spot syndrome virus infection
    Xiaoqian Tang, Ting Liu, Xiaoai Li, Xiuzhen Sheng, Jing Xing, Heng Chi, Wenbin Zhan
    Fish & Shellfish Immunology.2022; 122: 106.     CrossRef
  • The Critical Role Played by Mitochondrial MITF Serine 73 Phosphorylation in Immunologically Activated Mast Cells
    Lakshmi Bhargavi Paruchuru, Sharmila Govindaraj, Ehud Razin
    Cells.2022; 11(3): 589.     CrossRef
  • Glycemic Control and the Heart: The Tale of Diabetic Cardiomyopathy Continues
    Miriam Longo, Lorenzo Scappaticcio, Paolo Cirillo, Antonietta Maio, Raffaela Carotenuto, Maria Ida Maiorino, Giuseppe Bellastella, Katherine Esposito
    Biomolecules.2022; 12(2): 272.     CrossRef
  • Metabolic Reprogramming in Response to Alterations of Mitochondrial DNA and Mitochondrial Dysfunction in Gastric Adenocarcinoma
    Tzu-Ching Chang, Hui-Ting Lee, Siao-Cian Pan, Shih-Han Cho, Chieh Cheng, Liang-Hung Ou, Chia-I Lin, Chen-Sung Lin, Yau-Huei Wei
    International Journal of Molecular Sciences.2022; 23(3): 1857.     CrossRef
  • Toxicological effects of tris(1,3-dichloro-2-propyl) phosphate in oyster Crassostrea gigas using proteomic and phosphoproteomic analyses
    Chengcheng Yin, Zuodeng Sun, Chenglong Ji, Fei Li, Huifeng Wu
    Journal of Hazardous Materials.2022; 434: 128824.     CrossRef
  • Water-Extracted Prunella vulgaris Alleviates Endometriosis by Reducing Aerobic Glycolysis
    Min Kyoung Cho, Ling Jin, Jung Ho Han, Jung-Suk Jin, Se-Yun Cheon, Su Shin, Sung-Jin Bae, Jang-Kyung Park, Ki-Tae Ha
    Frontiers in Pharmacology.2022;[Epub]     CrossRef
  • Pyruvate Dehydrogenase A1 Phosphorylated by Insulin Associates with Pyruvate Kinase M2 and Induces LINC00273 through Histone Acetylation
    Abu Jubayer Hossain, Rokibul Islam, Jae-Gyu Kim, Oyungerel Dogsom, Kim Cuong Cap, Jae-Bong Park
    Biomedicines.2022; 10(6): 1256.     CrossRef
  • Celastrol alleviates high-fat diet-induced obesity via enhanced muscle glucose utilization and mitochondrial oxidative metabolism-mediated upregulation of pyruvate dehydrogenase complex
    Mohamad Hafizi Abu Bakar, Nor Shafiqah Nor Shahril, Mohamad Shamil Faris Mohamad Khalid, Sharifah Mohammad, Khairul Anuar Shariff, Thiruventhan Karunakaran, Rabeta Mohd Salleh, Mohamad Norisham Mohamad Rosdi
    Toxicology and Applied Pharmacology.2022; 449: 116099.     CrossRef
  • Regulation of Metabolism by Mitochondrial MUL1 E3 Ubiquitin Ligase
    Lucia Cilenti, Rohit Mahar, Jacopo Di Gregorio, Camilla T. Ambivero, Matthew E. Merritt, Antonis S. Zervos
    Frontiers in Cell and Developmental Biology.2022;[Epub]     CrossRef
  • The Pyruvate Dehydrogenase Complex Mitigates LPS-Induced Endothelial Barrier Dysfunction by Metabolic Regulation
    Liangfeng Mao, Maomao Sun, Zhenfeng Chen, Zhenhua Zeng, Jie Wu, Zhongqing Chen, Weijin Zhang, Qiaobing Huang
    Shock.2022; 57(6): 308.     CrossRef
  • Review: Influence of postabsorptive metabolism on essential amino acid partitioning in lactating dairy cows
    J.P. Cant, G.C. Reyes, D.J. Seymour
    animal.2022; 16: 100573.     CrossRef
  • T Cells Mediate Kidney Tubular Injury via Impaired PDHA1 and Autophagy in Type 1 Diabetes
    Chung-Hsing Wang, Wen-Li Lu, Shang-Lun Chiang, Tsung-Hsun Tsai, Su-Ching Liu, Chia-Hung Hsieh, Pen-Hua Su, Chih-Yang Huang, Fuu-Jen Tsai, Yu-Jung Lin, Yu-Nan Huang
    The Journal of Clinical Endocrinology & Metabolism.2022; 107(9): 2556.     CrossRef
  • Pyruvate Dehydrogenase Kinase Protects Dopaminergic Neurons from Oxidative Stress in Drosophila DJ-1 Null Mutants
    Yoonjeong Lee, Jaehyeon Kim, Hyunjin Kim, Ji Eun Han, Sohee Kim, Kyong-hwa Kang, Donghoon Kim, Jong-Min Kim, Hyongjong Koh
    Molecules and Cells.2022; 45(7): 454.     CrossRef
  • Metabolic regulation of T cell development
    Mengdi Zhang, Xiaoxi Lin, Zhou Yang, Xia Li, Zhiguang Zhou, Paul E. Love, Jiaqi Huang, Bin Zhao
    Frontiers in Immunology.2022;[Epub]     CrossRef
  • Noncanonical PDK4 action alters mitochondrial dynamics to affect the cellular respiratory status
    Themis Thoudam, Dipanjan Chanda, Ibotombi Singh Sinam, Byung-Gyu Kim, Mi-Jin Kim, Chang Joo Oh, Jung Yi Lee, Min-Ji Kim, Soo Yeun Park, Shin Yup Lee, Min-Kyo Jung, Ji Young Mun, Robert A. Harris, Naotada Ishihara, Jae-Han Jeon, In-Kyu Lee
    Proceedings of the National Academy of Sciences.2022;[Epub]     CrossRef
  • Frontiers in the enzymology of thiamin diphosphate-dependent enzymes
    Sabin Prajapati, Fabian Rabe von Pappenheim, Kai Tittmann
    Current Opinion in Structural Biology.2022; 76: 102441.     CrossRef
  • The Role of the Pyruvate Dehydrogenase Complex in the Development of Ischemic-Reperfusion Syndrome
    K. A. Popov, Ya. E. Denisova, I. M. Bykov, I. Yu. Tsymbalyuk, G. A. Ermakova, A. G. Zavgorodnyaya, A. S. Shevchenko
    Kuban Scientific Medical Bulletin.2022; 29(4): 75.     CrossRef
  • The fragility of liver glycogen from humans with type 2 diabetes: A pilot study
    Ziyi Wang, Xiaobo Min, Zhenxia Hu, Mitchell A. Sullivan, Yong Tang, Liang Wang, Robert G. Gilbert, Chen Shi, Bin Deng
    International Journal of Biological Macromolecules.2022; 221: 83.     CrossRef
  • Distinct role of mitochondrial function and protein kinase C in intimal and medial calcification in vitro
    Marina A. Heuschkel, Anne Babler, Jonas Heyn, Emiel P. C. van der Vorst, Marja Steenman, Maren Gesper, Ben A. Kappel, David Magne, Yann Gouëffic, Rafael Kramann, Willi Jahnen-Dechent, Nikolaus Marx, Thibaut Quillard, Claudia Goettsch
    Frontiers in Cardiovascular Medicine.2022;[Epub]     CrossRef
  • Metabolomic responses in livers of female and male zebrafish (Danio rerio) following prolonged exposure to environmental levels of zinc oxide nanoparticles
    Xiaohong Wang, Siying Chen, Yingju Qin, Haiqing Wang, Zhenda Liang, Yuanhui Zhao, Li Zhou, Christopher J. Martyniuk
    Aquatic Toxicology.2022; 253: 106333.     CrossRef
  • A Missense Variant in PDK1 Associated with Severe Neurodevelopmental Delay and Epilepsy
    Raquel Vaz, Josephine Wincent, Najla Elfissi, Kristina Rosengren Forsblad, Maria Pettersson, Karin Naess, Anna Wedell, Anna Wredenberg, Anna Lindstrand, Sofia Ygberg
    Biomedicines.2022; 10(12): 3171.     CrossRef
  • Rg3 regulates myocardial pyruvate metabolism via P300-mediated dihydrolipoamide dehydrogenase 2-hydroxyisobutyrylation in TAC-induced cardiac hypertrophy
    Jingyu Ni, Hao Zhang, Xiaodan Wang, Zhihao Liu, Tong Nie, Lan Li, Jing Su, Yan Zhu, Chuanrui Ma, Yuting Huang, Jingyuan Mao, Xiumei Gao, Guanwei Fan
    Cell Death & Disease.2022;[Epub]     CrossRef
  • Glutamine mitigates murine burn sepsis by supporting macrophage M2 polarization through repressing the SIRT5-mediated desuccinylation of pyruvate dehydrogenase
    Yuanfeng Zhu, Xiaoli Chen, Yongling Lu, Lin Xia, Shijun Fan, Qianying Huang, Xin Liu, Xi Peng
    Burns & Trauma.2022;[Epub]     CrossRef
  • Loss of metabolic flexibility as a result of overexpression of pyruvate dehydrogenase kinases in muscle, liver and the immune system: Therapeutic targets in metabolic diseases
    Jae‐Han Jeon, Themis Thoudam, Eun Jung Choi, Min‐Ji Kim, Robert A Harris, In‐Kyu Lee
    Journal of Diabetes Investigation.2021; 12(1): 21.     CrossRef
  • Insulin resistance is mechanistically linked to hepatic mitochondrial remodeling in non-alcoholic fatty liver disease
    Chris E. Shannon, Mukundan Ragavan, Juan Pablo Palavicini, Marcel Fourcaudot, Terry M Bakewell, Ivan A. Valdez, Iriscilla Ayala, Eunsook S. Jin, Muniswamy Madesh, Xianlin Han, Matthew E. Merritt, Luke Norton
    Molecular Metabolism.2021; 45: 101154.     CrossRef
  • Anti-Warburg Effect of Melatonin: A Proposed Mechanism to Explain its Inhibition of Multiple Diseases
    Russel J. Reiter, Ramaswamy Sharma, Sergio Rosales-Corral
    International Journal of Molecular Sciences.2021; 22(2): 764.     CrossRef
  • Hyperpolarized magnetic resonance shows that the anti‐ischemic drug meldonium leads to increased flux through pyruvate dehydrogenase in vivo resulting in improved post‐ischemic function in the diabetic heart
    Dragana Savic, Vicky Ball, Lorenz Holzner, David Hauton, Kerstin N. Timm, M. Kate Curtis, Lisa C. Heather, Damian J. Tyler
    NMR in Biomedicine.2021;[Epub]     CrossRef
  • Beyond the Warburg Effect: Oxidative and Glycolytic Phenotypes Coexist within the Metabolic Heterogeneity of Glioblastoma
    Tomás Duraj, Noemí García-Romero, Josefa Carrión-Navarro, Rodrigo Madurga, Ana Ortiz de Mendivil, Ricardo Prat-Acin, Lina Garcia-Cañamaque, Angel Ayuso-Sacido
    Cells.2021; 10(2): 202.     CrossRef
  • Detailed evaluation of pyruvate dehydrogenase complex inhibition in simulated exercise conditions
    Bodhi A. Jelinek, Michael A. Moxley
    Biophysical Journal.2021; 120(5): 936.     CrossRef
  • Proteomics Approach of Rapamycin Anti-Tumoral Effect on Primary and Metastatic Canine Mammary Tumor Cells In Vitro
    Patrícia F. Lainetti, Antonio F. Leis-Filho, Priscila E. Kobayashi, Laíza S. de Camargo, Renee Laufer-Amorim, Carlos E. Fonseca-Alves, Fabiana F. Souza
    Molecules.2021; 26(5): 1213.     CrossRef
  • Remodeling of Cancer-Specific Metabolism under Hypoxia with Lactate Calcium Salt in Human Colorectal Cancer Cells
    Keun-Yeong Jeong, Jae-Jun Sim, Min Hee Park, Hwan Mook Kim
    Cancers.2021; 13(7): 1518.     CrossRef
  • The Metabolic Fates of Pyruvate in Normal and Neoplastic Cells
    Edward V. Prochownik, Huabo Wang
    Cells.2021; 10(4): 762.     CrossRef
  • The Multifaceted Roles of Zinc in Neuronal Mitochondrial Dysfunction
    Hilary Y. Liu, Jenna R. Gale, Ian J. Reynolds, John H. Weiss, Elias Aizenman
    Biomedicines.2021; 9(5): 489.     CrossRef
  • Melatonin inhibits lung cancer development by reversing the Warburg effect via stimulating the SIRT3/PDH axis
    Xiangyun Chen, Bingjie Hao, Dan Li, Russel J. Reiter, Yidong Bai, Baigenzhin Abay, Guojie Chen, Shumeng Lin, Tiansheng Zheng, Yanbei Ren, Xiao Xu, Ming Li, Lihong Fan
    Journal of Pineal Research.2021;[Epub]     CrossRef
  • Differential expression of pyruvate dehydrogenase E1A and its inactive phosphorylated form among breast cancer subtypes
    Dana M. Zaher, Iman M. Talaat, Amal Hussein, Mahmood Y. Hachim, Hany A. Omar
    Life Sciences.2021; 284: 119885.     CrossRef
  • Structure of the native pyruvate dehydrogenase complex reveals the mechanism of substrate insertion
    Jana Škerlová, Jens Berndtsson, Hendrik Nolte, Martin Ott, Pål Stenmark
    Nature Communications.2021;[Epub]     CrossRef
  • Melatonin: Regulation of Biomolecular Condensates in Neurodegenerative Disorders
    Doris Loh, Russel J. Reiter
    Antioxidants.2021; 10(9): 1483.     CrossRef
  • Comprehensive Interrogation of Metabolic and Bioenergetic Responses of Early-Staged Zebrafish (Danio rerio) to a Commercial Copper Hydroxide Nanopesticide
    Xiaohong Wang, Yingju Qin, Xiaoyu Li, Bing Yan, Christopher J. Martyniuk
    Environmental Science & Technology.2021;[Epub]     CrossRef
  • Conditional Knockout of Pdha1 in Mouse Hippocampus Impairs Cognitive Function: The Possible Involvement of Lactate
    Wanxin Chen, Xiaoxia Sun, Libin Zhan, Wen Zhou, Tingting Bi
    Frontiers in Neuroscience.2021;[Epub]     CrossRef
  • Dihydrolipoamide dehydrogenase, pyruvate oxidation, and acetylation-dependent mechanisms intersecting drug iatrogenesis
    I. F. Duarte, J. Caio, M. F. Moedas, L. A. Rodrigues, A. P. Leandro, I. A. Rivera, M. F. B. Silva
    Cellular and Molecular Life Sciences.2021; 78(23): 7451.     CrossRef
  • Advanced Bioinformatics Tools in the Pharmacokinetic Profiles of Natural and Synthetic Compounds with Anti-Diabetic Activity
    Ana Maria Udrea, Gratiela Gradisteanu Pircalabioru, Anca Andreea Boboc, Catalina Mares, Andra Dinache, Maria Mernea, Speranta Avram
    Biomolecules.2021; 11(11): 1692.     CrossRef
  • Obesidade e infecção por SARS-CoV-2: papel da metainflamação
    Ana Luísa Silva Albertoni, Luis Gustavo Silva Albertoni, Patricia Elaine de Almeida
    HU Revista.2021; 46: 1.     CrossRef
  • Influenza and obesity: its odd relationship and the lessons for COVID-19 pandemic
    Livio Luzi, Maria Grazia Radaelli
    Acta Diabetologica.2020; 57(6): 759.     CrossRef
  • Acquisition of exogenous fatty acids renders apicoplast-based biosynthesis dispensable in tachyzoites of Toxoplasma
    Xiaohan Liang, Jianmin Cui, Xuke Yang, Ningbo Xia, Yaqiong Li, Junlong Zhao, Nishith Gupta, Bang Shen
    Journal of Biological Chemistry.2020; 295(22): 7743.     CrossRef
  • Stimulation of glycolysis promotes cardiomyocyte proliferation after injury in adult zebrafish
    Ryuichi Fukuda, Rubén Marín‐Juez, Hadil El‐Sammak, Arica Beisaw, Radhan Ramadass, Carsten Kuenne, Stefan Guenther, Anne Konzer, Aditya M Bhagwat, Johannes Graumann, Didier YR Stainier
    EMBO reports.2020;[Epub]     CrossRef
  • Fat mass affects nutritional status of ICU COVID-19 patients
    Antonino De Lorenzo, Maria Grazia Tarsitano, Carmela Falcone, Laura Di Renzo, Lorenzo Romano, Sebastiano Macheda, Anna Ferrarelli, Demetrio Labate, Marco Tescione, Federico Bilotta, Paola Gualtieri
    Journal of Translational Medicine.2020;[Epub]     CrossRef
  • Conditional knockout of pyruvate dehydrogenase in mouse pancreatic β‑cells causes morphological and functional changes
    Xiao Wang, Shuchang Lai, Yanshi Ye, Yuanyuan Hu, Daoyan Pan, Xiaochun Bai, Jie Shen
    Molecular Medicine Reports.2020;[Epub]     CrossRef
  • Beneficial Effects of Acetyl-DL-Leucine (ADLL) in a Mouse Model of Sandhoff Disease
    Ecem Kaya, David A. Smith, Claire Smith, Barry Boland, Michael Strupp, Frances M. Platt
    Journal of Clinical Medicine.2020; 9(4): 1050.     CrossRef
  • Fetal circulating human resistin increases in diabetes during pregnancy and impairs placental mitochondrial biogenesis
    Shaoning Jiang, April M. Teague, Jeanie B. Tryggestad, Timothy J. Lyons, Steven D. Chernausek
    Molecular Medicine.2020;[Epub]     CrossRef
  • SARS-CoV-2-host dynamics: Increased risk of adverse outcomes of COVID-19 in obesity
    Rakhee Yadav, Sandeep Aggarwal, Archna Singh
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2020; 14(5): 1355.     CrossRef
  • Effect of flaxseed oil on muscle protein loss and carbohydrate oxidation impairment in a pig model after lipopolysaccharide challenge
    Ping Kang, Yang Wang, Xiangen Li, Zhicheng Wan, Xiuying Wang, Huiling Zhu, Chunwei Wang, Shengjun Zhao, Huifu Chen, Yulan Liu
    British Journal of Nutrition.2020; 123(8): 859.     CrossRef
  • Arrangement and symmetry of the fungal E3BP-containing core of the pyruvate dehydrogenase complex
    B. O. Forsberg, S. Aibara, R. J. Howard, N. Mortezaei, E. Lindahl
    Nature Communications.2020;[Epub]     CrossRef
  • The potential impacts of obesity on COVID-19
    Ahmed Abdalazim Dafallah Albashir
    Clinical Medicine.2020; 20(4): e109.     CrossRef
  • Selective dietary polyphenols induce differentiation of human osteoblasts by adiponectin receptor 1-mediated reprogramming of mitochondrial energy metabolism
    Subhashis Pal, Konica Porwal, Sangam Rajak, Rohit A. Sinha, Naibedya Chattopadhyay
    Biomedicine & Pharmacotherapy.2020; 127: 110207.     CrossRef
  • Factors Associated with Increased Morbidity and Mortality of Obese and Overweight COVID-19 Patients
    Amany Magdy Beshbishy, Helal F. Hetta, Diaa E. Hussein, Abdullah A. Saati, Christian C. Uba, Nallely Rivero-Perez, Adrian Zaragoza-Bastida, Muhammad Ajmal Shah, Tapan Behl, Gaber El-Saber Batiha
    Biology.2020; 9(9): 280.     CrossRef
  • Increased Glucose Availability Attenuates Myocardial Ketone Body Utilization
    Manoja K. Brahma, Chae‐Myeong Ha, Mark E. Pepin, Sobuj Mia, Zhihuan Sun, John C. Chatham, Kirk M. Habegger, Evan Dale Abel, Andrew J. Paterson, Martin E. Young, Adam R. Wende
    Journal of the American Heart Association.2020;[Epub]     CrossRef
  • Stimulating pyruvate dehydrogenase complex reduces itaconate levels and enhances TCA cycle anabolic bioenergetics in acutely inflamed monocytes
    Xuewei Zhu, David Long, Manal Zabalawi, Brian Ingram, Barbara K. Yoza, Peter W. Stacpoole, Charles E. McCall
    Journal of Leukocyte Biology.2020; 107(3): 467.     CrossRef
  • Short-term high-fat diet intake leads to exacerbation of concanavalin A-induced liver injury through the induction of procoagulation state
    Eri Nanizawa, Yuki Tamaki, Reika Sono, Rintaro Miyashita, Yumi Hayashi, Ayumu Kanbe, Hiroyasu Ito, Tetsuya Ishikawa
    Biochemistry and Biophysics Reports.2020; 22: 100736.     CrossRef
  • Role of the Mitochondrial Pyruvate Carrier in the Occurrence of Metabolic Inflexibility in Drosophila melanogaster Exposed to Dietary Sucrose
    Chloé J. Simard, Mohamed Touaibia, Eric Pierre Allain, Etienne Hebert-Chatelain, Nicolas Pichaud
    Metabolites.2020; 10(10): 411.     CrossRef
  • Metabolic shift underlies recovery in reversible infantile respiratory chain deficiency
    Denisa Hathazi, Helen Griffin, Matthew J Jennings, Michele Giunta, Christopher Powell, Sarah F Pearce, Benjamin Munro, Wei Wei, Veronika Boczonadi, Joanna Poulton, Angela Pyle, Claudia Calabrese, Aurora Gomez‐Duran, Ulrike Schara, Robert D S Pitceathly, M
    The EMBO Journal.2020;[Epub]     CrossRef
  • Increased pyruvate dehydrogenase activity in skeletal muscle of growth-restricted ovine fetuses
    Alexander L. Pendleton, Laurel R. Humphreys, Melissa A. Davis, Leticia E. Camacho, Miranda J. Anderson, Sean W. Limesand
    American Journal of Physiology-Regulatory, Integrative and Comparative Physiology.2019; 317(4): R513.     CrossRef
  • Recent advances in the pathogenesis of microvascular complications in diabetes
    Sungmi Park, Hyeon-Ji Kang, Jae-Han Jeon, Min-Ji Kim, In-Kyu Lee
    Archives of Pharmacal Research.2019; 42(3): 252.     CrossRef
  • Secondary Metabolites of The Endophytic Fungus Alternaria alternata JS0515 Isolated from Vitex rotundifolia and Their Effects on Pyruvate Dehydrogenase Activity
    Changyeol Lee, Wei Li, Sunghee Bang, Sun Joo Lee, Nam-young Kang, Soonok Kim, Tae In Kim, Younghoon Go, Sang Hee Shim
    Molecules.2019; 24(24): 4450.     CrossRef
  • Adaptations in Protein Expression and Regulated Activity of Pyruvate Dehydrogenase Multienzyme Complex in Human Systolic Heart Failure
    Freya L. Sheeran, Julie Angerosa, Norman Y. Liaw, Michael M. Cheung, Salvatore Pepe
    Oxidative Medicine and Cellular Longevity.2019; 2019: 1.     CrossRef
  • Progression of Multifaceted Immune Cells in Atherosclerotic Development
    Sungmi Park, In-Kyu Lee
    Journal of Lipid and Atherosclerosis.2019; 8(1): 15.     CrossRef
  • SIRT3 elicited an anti‐Warburg effect through HIF1α/PDK1/PDHA1 to inhibit cholangiocarcinoma tumorigenesis
    Lei Xu, Yang Li, Lixing Zhou, Robert Gregory Dorfman, Li Liu, Rui Cai, Chenfei Jiang, Dehua Tang, Yuming Wang, Xiaoping Zou, Lei Wang, Mingming Zhang
    Cancer Medicine.2019; 8(5): 2380.     CrossRef
  • Differential Mechanism of ATP Production Occurs in Response to Succinylacetone in Colon Cancer Cells
    Phil Jun Lee, Seung Je Woo, Hee Min Yoo, Namki Cho, Hong Pyo Kim
    Molecules.2019; 24(19): 3575.     CrossRef
  • Myocardial Adaptation in Pseudohypoxia: Signaling and Regulation of mPTP via Mitochondrial Connexin 43 and Cardiolipin
    Miroslav Ferko, Natália Andelová, Barbara Szeiffová Bačová, Magdaléna Jašová
    Cells.2019; 8(11): 1449.     CrossRef
  • NDUFAB1 protects against obesity and insulin resistance by enhancing mitochondrial metabolism
    Rufeng Zhang, Tingting Hou, Heping Cheng, Xianhua Wang
    The FASEB Journal.2019; 33(12): 13310.     CrossRef
  • Mitochondrial Flexibility of Breast Cancers: A Growth Advantage and a Therapeutic Opportunity
    Angelica Avagliano, Maria Rosaria Ruocco, Federica Aliotta, Immacolata Belviso, Antonello Accurso, Stefania Masone, Stefania Montagnani, Alessandro Arcucci
    Cells.2019; 8(5): 401.     CrossRef
  • Effects of intermittent hypoxia training on leukocyte pyruvate dehydrogenase kinase 1 (PDK-1) mRNA expression and blood insulin level in prediabetes patients
    Tetiana V. Serebrovska, Alla G. Portnychenko, Vladimir I. Portnichenko, Lei Xi, Egor Egorov, Ivanna Antoniuk-Shcheglova, Svitlana Naskalova, Valeriy B. Shatylo
    European Journal of Applied Physiology.2019; 119(3): 813.     CrossRef
Editorial
Epidemiology
Can Air Pollution Biologically Hinder Efforts to Lose Body Weight?
Duk-Hee Lee
Diabetes Metab J. 2018;42(4):282-284.   Published online August 21, 2018
DOI: https://doi.org/10.4093/dmj.2018.0139
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  • Sex-specific effects of blood cadmium on thyroid hormones and thyroid function status: Korean nationwide cross-sectional study
    Seung Min Chung, Jun Sung Moon, Ji Sung Yoon, Kyu Chang Won, Hyoung Woo Lee
    Journal of Trace Elements in Medicine and Biology.2019; 53: 55.     CrossRef
Original Articles
Clinical Diabetes and Therapeutics
Cardio-Ankle Vascular Index as a Surrogate Marker of Early Atherosclerotic Cardiovascular Disease in Koreans with Type 2 Diabetes Mellitus
So Young Park, Sang Ook Chin, Sang Youl Rhee, Seungjoon Oh, Jeong-Taek Woo, Sung Woon Kim, Suk Chon
Diabetes Metab J. 2018;42(4):285-295.   Published online July 27, 2018
DOI: https://doi.org/10.4093/dmj.2017.0080
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AbstractAbstract PDFPubReader   
Background

Carotid artery intima medial thickness (IMT), brachial-ankle pulse wave velocity (baPWV), and ankle-brachial index (ABI) are commonly used surrogate markers of subclinical atherosclerosis in patients with type 2 diabetes mellitus (T2DM). The cardio-ankle vascular index (CAVI) is a complement to the baPWV, which is affected by blood pressure. However, it is unclear which marker is the most sensitive predictor of atherosclerotic cardiovascular disease (ASCVD).

Methods

This was a retrospective non-interventional study that enrolled 219 patients with T2DM. The correlations among IMT, ABI, and CAVI as well as the relationship of these tests to the 10-year ASCVD risk were also analyzed.

Results

Among the 219 patients, 39 (17.8%) had ASCVD. In the non-ASCVD group, CAVI correlated significantly with IMT after adjusting for confounding variables, but ABI was not associated with CAVI or IMT. The analyses after dividing the non-ASCVD group into three subgroups according to the CAVI score (<8, ≥8 and <9, and ≥9) demonstrated the significant increase in the mean IMT, 10-year ASCVD risk and number of metabolic syndrome risk factors, and decrease in the mean ABI in the high-CAVI group. A high CAVI was an independent risk factor in the non-ASCVD group for both a high 10-year ASCVD risk (≥7.5%; odds ratio [OR], 2.42; P<0.001) and atherosclerosis (mean IMT ≥1 mm; OR, 1.53; P=0.007).

Conclusion

In Korean patients with T2DM without ASCVD, CAVI was the most sensitive of several surrogate markers for the detection of subclinical atherosclerosis.

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  • The effects of severe periodontitis on arterial stiffness using cardio‐ankle vascular index in patients with type 2 diabetes
    Gizem Torumtay Cin, Semin Melahat Fenkci, Ismail Doğu Kiliç, Halil Serdar Aslan, Cihan İlyas Sevgican, Hande Şenol
    Journal of Periodontal Research.2024; 59(1): 74.     CrossRef
  • Predictive value of Systematic Coronary Risk Evaluation 2‐Diabetes risk model and arterial stiffness for cardiovascular events in the Asian population with type 2 diabetes mellitus
    Pannipa Suwannasom, Tasalak Thonghong, Krit Leemasawat, Teerapat Nantsupawat, Narawudt Prasertwitayakij, Chutamas Pairoj, Wanwarang Wongcharoen, Arintaya Phrommintikul
    Journal of Diabetes Investigation.2024; 15(9): 1266.     CrossRef
  • Prediction of cardiovascular disease using deep learning algorithms to prevent COVID 19
    Malathi S, Arockia Raj Y, Abhishek Kumar, V D Ashok Kumar, Ankit Kumar, Elangovan D, V D Ambeth Kumar, Chitra B, a Abirami
    Journal of Experimental & Theoretical Artificial Intelligence.2023; 35(6): 791.     CrossRef
  • Association of cardio-ankle vascular index and future major adverse cardiovascular events in older adults living with HIV
    Amaraporn Rerkasem, Arunrat Tangmunkongvorakul, Linda Aurpibul, Patumrat Sripan, Wason Parklak, Sothida Nantakool, Kriengkrai Srithanaviboonchai, Kittipan Rerkasem
    AIDS Care.2023; 35(4): 591.     CrossRef
  • Impact of Fasting Blood Glucose Levels on Blood Pressure Parameters among Older Adults with Prediabetes
    Thapanee Roengrit, Ruchada Sri-Amad, Nawiya Huipao, Suphawadee Phababpha, Piyapong Prasertsri, Francesco Giallauria
    The Scientific World Journal.2023; 2023: 1.     CrossRef
  • A framework of biomarkers for vascular aging: a consensus statement by the Aging Biomarker Consortium
    Le Zhang, Jun Guo, Yuehong Liu, Shimin Sun, Baohua Liu, Qi Yang, Jun Tao, Xiao-Li Tian, Jun Pu, Huashan Hong, Miao Wang, Hou-Zao Chen, Jie Ren, Xiaoming Wang, Zhen Liang, Yuan Wang, Kai Huang, Weiqi Zhang, Jing Qu, Zhenyu Ju, Guang-Hui Liu, Gang Pei, Jian
    Life Medicine.2023;[Epub]     CrossRef
  • Diastolic Pressure and ACR Are Modifiable Risk Factors of Arterial Stiffness in T2DM Without Cardiovascular Disease
    Gateano Leto, Lida Tartaglione, Silverio Rotondi, Marzia Pasquali, Ernesto Maddaloni, Carmen Mignogna, Luca D’Onofrio, Simona Zampetti, Angela Carlone, Maria Luisa Muci, Daniela Mastroluca, Valeria Fassino, Raffaella Buzzetti, Sandro Mazzaferro
    The Journal of Clinical Endocrinology & Metabolism.2022; 107(9): e3857.     CrossRef
  • Risk assessment indicators and brachial-ankle pulse wave velocity to predict atherosclerotic cardiovascular disease
    Hung-Ju Ko, Chuan-Chuan Liu, Po-Jui Hsu, Kuang-Chun Hu, Chung-Lieh Hung, Lo-Yip Yu, Yun-Chieh Huang, Shou-Chuan Shih
    Medicine.2022; 101(32): e29609.     CrossRef
  • Prediction of Cardiovascular Disease Using Machine Learning Technique—A Modern Approach
    Jung-Hwa Kim, Jin-Woo Jeong
    Computers, Materials & Continua.2022; 71(1): 855.     CrossRef
  • Cardio-ankle vascular index represents the best surrogate for 10-year ASCVD risk estimation in patients with primary hypertension
    Mustafa Tarik Agac, Süret Ağaç, Muhammed Necati Murat Aksoy, Mehmet Bülent Vatan
    Clinical and Experimental Hypertension.2021; 43(4): 349.     CrossRef
  • Relation between fragmented QRS complex and cardio-ankle vascular index in asymptomatic subjects
    Ali Rıza Akyüz, Sinan Şahin, Ömer Faruk Çırakoğlu, Selim Kul, Turhan Turan, Hakan Erkan
    Clinical and Experimental Hypertension.2021; 43(4): 368.     CrossRef
  • Progress of clinical evaluation for vascular aging in humans
    Yumin Qiu, Yuanya Liu, Jun Tao
    Journal of Translational Internal Medicine.2021; 9(1): 17.     CrossRef
  • Effects of long-term air pollution exposure on ankle-brachial index and cardio-ankle vascular index: A longitudinal cohort study using data from the Electricity Generating Authority of Thailand study
    Kanawat Paoin, Kayo Ueda, Prin Vathesatogkit, Thammasin Ingviya, Suhaimee Buya, Arthit Phosri, Xerxes Tesoro Seposo, Nisakron Thongmung, Teerapat Yingchoncharoen, Akiko Honda, Hirohisa Takano, Piyamitr Sritara
    International Journal of Hygiene and Environmental Health.2021; 236: 113790.     CrossRef
  • The Relationship Between Glycemic Control and Concomitant Hypertension on Arterial Stiffness in Type II Diabetes


    Teonchit Nuamchit, Duangduan Siriwittayawan, Piyanuch Thitiwuthikiat
    Vascular Health and Risk Management.2020; Volume 16: 343.     CrossRef
  • Relationship between cardio-ankle vascular index and obstructive coronary artery disease
    Divya Birudaraju, Lavanya Cherukuri, April Kinninger, Bhanu T. Chaganti, Pishoy Haroun, Sivakrishna Pidikiti, Suvasini Lakshmanan, Sajad Hamal, Ferdinand Flores, Christopher Dailing, Kashif Shaikh, Sion K. Roy, Matthew J. Budoff
    Coronary Artery Disease.2020; 31(6): 550.     CrossRef
  • Association of Kidney Function Tests with a Cardio-Ankle Vascular Index in Community-Dwelling Individuals with a Normal or Mildly Decreased Estimated Glomerular Filtration Rate
    Javad Alizargar, Chyi-Huey Bai, Nan-Chen Hsieh, Shu-Fang Vivienne Wu, Shih-Yen Weng, Jia-Ping Wu
    Medicina.2019; 55(10): 657.     CrossRef
  • Cardiovascular remodeling in patients with diabetic сardiomyopathy
    A. S. Veklich, N. A. Koziolova, P. G. Karavaev
    Russian Journal of Cardiology.2019; (11): 42.     CrossRef
  • Short‑term impact of aged garlic extract on endothelial function in diabetes: A randomized, double‑blind, placebo‑controlled trial
    Sajad Hamal, Lavanya Cherukuri, Divya Birudaraju, Suguru Matsumoto, April Kinninger, Bhanu Chaganti, Ferdinand Flores, Kashif Shaikh, Sion Roy, Matthew Budoff
    Experimental and Therapeutic Medicine.2019;[Epub]     CrossRef
  • Association between Breakfast Frequency and Atherosclerotic Cardiovascular Disease Risk: A Cross-Sectional Study of KNHANES Data, 2014–2016
    Hyeon Ji Lee, Jieun Jang, Sang Ah Lee, Dong-Woo Choi, Eun-Cheol Park
    International Journal of Environmental Research and Public Health.2019; 16(10): 1853.     CrossRef
  • Response: Cardio-Ankle Vascular Index as a Surrogate Marker of Early Atherosclerotic Cardiovascular Disease in Koreans with Type 2 Diabetes Mellitus (Diabetes Metab J 2018;42:285-95)
    So Young Park, Suk Chon
    Diabetes & Metabolism Journal.2018; 42(5): 449.     CrossRef
  • Letter: Cardio-Ankle Vascular Index as a Surrogate Marker of Early Atherosclerotic Cardiovascular Disease in Koreans with Type 2 Diabetes Mellitus (Diabetes Metab J 2018;42:285-95)
    Dongwon Yi
    Diabetes & Metabolism Journal.2018; 42(5): 447.     CrossRef
Epidemiology
Insulin Resistance and the Risk of Diabetes and Dysglycemia in Korean General Adult Population
Jong Ha Baek, Hosu Kim, Kyong Young Kim, Jaehoon Jung
Diabetes Metab J. 2018;42(4):296-307.   Published online April 24, 2018
DOI: https://doi.org/10.4093/dmj.2017.0106
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AbstractAbstract PDFSupplementary MaterialPubReader   
Background

Insulin resistance is a major pathogenic hallmark of impaired glucose metabolism. We assessed the accuracy of insulin resistance and cut-off values using homeostasis model assessment of insulin resistance (HOMA-IR) to classify type 2 diabetes mellitus (T2DM) and dysglycemia according to age and sex.

Methods

In this cross-sectional study, we analyzed 4,291 anti-diabetic drug-naïve adults (≥20 years) from the 6th Korea National Health and Nutrition Examination Survey in 2015. Metabolic syndrome (MetS) was defined by the modified National Cholesterol Education Program III guideline. Diagnosis of dysglycemia and T2DM were based on fasting glucose and glycosylated hemoglobin levels. The receiver operating characteristic curve and optimal cut-off values of HOMA-IR were assessed to identify T2DM/dysglycemia according to sex and were further analyzed by age.

Results

Sex differences were found in the association of MetS and the different MetS components with T2DM/dysglycemia. The overall optimal cut-off value of HOMA-IR for identifying dysglycemia was 1.6 in both sex. The cut-off values for T2DM were 2.87 in men and 2.36 in women. However, there are differences in diagnostic range of HOMA-IR to distinguish T2DM according to sex and age, and the accuracy of HOMA-IR in identifying T2DM gradually decreased with age especially in women.

Conclusion

Insulin resistance is closely associated with the risk for T2DM/dysglycemia. The accuracy of HOMA-IR levels is characterized by sex- and age-specific differences in identifying T2DM. In addition to insulin resistance index, insulin secretory function, and different MetS components should be considered in the detection of early T2DM, especially in elderly.

Citations

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  • Evaluation of insulin secretion and insulin sensitivity in pregnant women: Application value of simple indices
    Shuying Ren, Dan Wu, Ping Li
    Clinica Chimica Acta.2024; 554: 117753.     CrossRef
  • Association between birth weight and insulin resistance in US adolescents: A retrospective cohort study exploring the role of concurrent body mass index
    Yubo Zhuo, Jieli He, Liangbing Wang, Chun Bong Chow, Frederick K. Ho
    Nutrition, Metabolism and Cardiovascular Diseases.2024; 34(4): 1061.     CrossRef
  • The Impact of Japanese Dietary Patterns on Metabolic Dysfunction-Associated Steatotic Liver Disease and Liver Fibrosis
    Takafumi Sasada, Chikara Iino, Satoshi Sato, Tetsuyuki Tateda, Go Igarashi, Kenta Yoshida, Kaori Sawada, Tatsuya Mikami, Shigeyuki Nakaji, Hirotake Sakuraba, Shinsaku Fukuda
    Nutrients.2024; 16(17): 2877.     CrossRef
  • Risk of Colorectal Cancer among Patients with One or Multiple Metabolic Syndrome Components
    Shanmuga Sundaram, Rajan Lamichhane, Alfred Cecchetti, Usha Murughiyan, Uma Sundaram
    Cancers.2024; 16(19): 3350.     CrossRef
  • Ziziphus jujuba (Jujube) in Metabolic Syndrome: From Traditional Medicine to Scientific Validation
    Mahboobeh Ghasemzadeh Rahbardar, Homa Fazeli Kakhki, Hossein Hosseinzadeh
    Current Nutrition Reports.2024; 13(4): 845.     CrossRef
  • Biomarkers of insulin sensitivity/resistance
    Constantine E Kosmas, Andreas Sourlas, Konstantinos Oikonomakis, Eleni-Angeliki Zoumi, Aikaterini Papadimitriou, Christina E Kostara
    Journal of International Medical Research.2024;[Epub]     CrossRef
  • Are HOMA-IR and HOMA-B good predictors for diabetes and pre-diabetes subtypes?
    Davood Khalili, Marjan Khayamzadeh, Karim Kohansal, Noushin Sadat Ahanchi, Mitra Hasheminia, Farzad Hadaegh, Maryam Tohidi, Fereidoun Azizi, Ali Siamak Habibi-Moeini
    BMC Endocrine Disorders.2023;[Epub]     CrossRef
  • Non-Alcoholic Fatty Liver Disease with Sarcopenia and Carotid Plaque Progression Risk in Patients with Type 2 Diabetes Mellitus
    Yongin Cho, Hye-Sun Park, Byung Wook Huh, Yong-ho Lee, Seong Ha Seo, Da Hea Seo, Seong Hee Ahn, Seongbin Hong, So Hun Kim
    Diabetes & Metabolism Journal.2023; 47(2): 232.     CrossRef
  • Triglyceride-Glucose Index Cutoff Point Is an Accurate Marker for Predicting the Prevalence of Metabolic Syndrome in Obese Caucasian Subjects
    David Primo, Olatz Izaola, Daniel A. de Luis
    Annals of Nutrition and Metabolism.2023; 79(2): 238.     CrossRef
  • Triglyceride glucose index as a predictor of mortality in middle-aged and elderly patients with type 2 diabetes in the US
    Mengjie Zhao, Mengli Xiao, Qin Tan, Fang Lu
    Scientific Reports.2023;[Epub]     CrossRef
  • Assessment HOMA as a predictor for new onset diabetes mellitus and diabetic complications in non-diabetic adults: a KoGES prospective cohort study
    Jibeom Lee, Moon-hyun Kim, Ji-Yong Jang, Chang-Myung Oh
    Clinical Diabetes and Endocrinology.2023;[Epub]     CrossRef
  • Association between experience of insulin resistance and long-term cardiovascular disease risk: findings from the Korean Genome and Epidemiology Study (KOGES)
    Jong Hee Lee, Hye Sun Lee, Soyoung Jeon, Yong-Jae Lee, Byoungjin Park, Jun-Hyuk Lee, Yu-Jin Kwon
    Endocrine.2023; 84(2): 481.     CrossRef
  • Efficacy and safety of evogliptin in patients with type 2 diabetes and non‐alcoholic fatty liver disease: A multicentre, double‐blind, randomized, comparative trial
    Eugene Han, Ji Hye Huh, Eun Y. Lee, Ji C. Bae, Sung W. Chun, Sung H. Yu, Soo H. Kwak, Kyong S. Park, Byung‐Wan Lee
    Diabetes, Obesity and Metabolism.2022; 24(4): 752.     CrossRef
  • Development and Validation of an Insulin Resistance Predicting Model Using a Machine-Learning Approach in a Population-Based Cohort in Korea
    Sunmin Park, Chaeyeon Kim, Xuangao Wu
    Diagnostics.2022; 12(1): 212.     CrossRef
  • HOMA-IR as a predictor of Health Outcomes in Patients with Metabolic Risk Factors: A Systematic Review and Meta-analysis
    José G. González-González, Jorge R. Violante-Cumpa, Miguel Zambrano-Lucio, Erick Burciaga-Jimenez, Patricia L. Castillo-Morales, Mariano Garcia-Campa, Ricardo César Solis, Alejandro D González-Colmenero, René Rodríguez-Gutiérrez
    High Blood Pressure & Cardiovascular Prevention.2022; 29(6): 547.     CrossRef
  • A Comprehensive Analysis of Chinese, Japanese, Korean, US-PIMA Indian, and Trinidadian Screening Scores for Diabetes Risk Assessment and Prediction
    Norma Latif Fitriyani, Muhammad Syafrudin, Siti Maghfirotul Ulyah, Ganjar Alfian, Syifa Latif Qolbiyani, Muhammad Anshari
    Mathematics.2022; 10(21): 4027.     CrossRef
  • Osteocalcin is associated with triglyceride glucose index rather than HOMA-IR in men with type 2 diabetes
    Huijie Huang, Ai Wang, Li Cong, Yingjuan Zeng
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • The insulin resistance by triglyceride glucose index and risk for dementia: population-based study
    Sangmo Hong, Kyungdo Han, Cheol-Young Park
    Alzheimer's Research & Therapy.2021;[Epub]     CrossRef
  • Association between insulin resistance and lung function trajectory over 4 years in South Korea: community-based prospective cohort
    Sang Hyuk Kim, Hyun Sam Kim, Hyang Ki Min, Sung Woo Lee
    BMC Pulmonary Medicine.2021;[Epub]     CrossRef
  • The triglyceride–glucose index is a more powerful surrogate marker for predicting the prevalence and incidence of type 2 diabetes mellitus than the homeostatic model assessment of insulin resistance
    Hye Min Park, Hye Sun Lee, Yong-Jae Lee, Jun-Hyuk Lee
    Diabetes Research and Clinical Practice.2021; 180: 109042.     CrossRef
  • The effect of 1% glucose loading on metabolism in the elderly patients during remifentanil-induced anesthesia: a randomized controlled trial
    Kohei Fukuta, Asuka Kasai, Noriko Niki, Yuki Ishikawa, Ryosuke Kawanishi, Nami Kakuta, Yoko Sakai, Yasuo M. Tsutsumi, Katsuya Tanaka
    BMC Anesthesiology.2020;[Epub]     CrossRef
  • Suppression of HDAC by sodium acetate rectifies cardiac metabolic disturbance in streptozotocin–nicotinamide-induced diabetic rats
    Kehinde S Olaniyi, Oluwatobi A Amusa, Emmanuel D Areola, Lawrence A Olatunji
    Experimental Biology and Medicine.2020; 245(7): 667.     CrossRef
  • Non-alcoholic steatohepatitis and progression of carotid atherosclerosis in patients with type 2 diabetes: a Korean cohort study
    Hyeok-Hee Lee, Yongin Cho, Young Ju Choi, Byung Wook Huh, Byung-Wan Lee, Eun Seok Kang, Seok Won Park, Bong-Soo Cha, Eun Jig Lee, Yong-ho Lee, Kap Bum Huh
    Cardiovascular Diabetology.2020;[Epub]     CrossRef
  • Triglyceride Glucose-Waist Circumference Better Predicts Coronary Calcium Progression Compared with Other Indices of Insulin Resistance: A Longitudinal Observational Study
    Yun Kyung Cho, Jiwoo Lee, Hwi Seung Kim, Eun Hee Kim, Min Jung Lee, Dong Hyun Yang, Joon-Won Kang, Chang Hee Jung, Joong-Yeol Park, Hong-Kyu Kim, Woo Je Lee
    Journal of Clinical Medicine.2020; 10(1): 92.     CrossRef
  • Anthropometric features in predicting insulin resistance among non-menopausal Indonesian adult females
    Liong Boy Kurniawan, Bachtiar Syamsir, Ilham Akbar Rahman, Endy Adnan, Tenri Esa, Yuyun Widaningsih, Uleng Bahrun, Mansyur Arif
    Romanian Journal of Internal Medicine.2020; 58(3): 168.     CrossRef
  • Effects of magnitude of visceral adipose tissue reduction: Impact on insulin resistance, hyperleptinemia and cardiometabolic risk in adolescents with obesity after long-term weight-loss therapy
    Raquel Munhoz da Silveira Campos, Deborah Cristina Landi Masquio, Flávia Campos Corgosinho, Danielle Arisa Caranti, Aline de Piano Ganen, Lian Tock, Lila Missae Oyama, Ana Raimunda Dâmaso
    Diabetes and Vascular Disease Research.2019; 16(2): 196.     CrossRef
  • Mediation analysis of dietary habits, nutrient intakes, daily life in the relationship between working hours of Korean shift workers and metabolic syndrome : the sixth (2013 ~ 2015) Korea National Health and Nutrition Examination Survey
    Yoona Kim, Hyeon Hee Kim, Dong Hoon Lim
    Journal of Nutrition and Health.2018; 51(6): 567.     CrossRef
  • The cut-off values of surrogate measures for insulin resistance in the Korean population according to the Korean Genome and Epidemiology Study (KOGES)
    Bongyoung Kim, Hyun Young Choi, Wonhee Kim, Chiwon Ahn, Juncheol Lee, Jae Guk Kim, Jihoon Kim, Hyungoo Shin, Jae Myung Yu, Shinje Moon, Taulant Muka
    PLOS ONE.2018; 13(11): e0206994.     CrossRef
Epidemiology
The Changes of Trends in the Diagnosis and Treatment of Diabetic Foot Ulcer over a 10-Year Period: Single Center Study
Choong Hee Kim, Jun Sung Moon, Seung Min Chung, Eun Jung Kong, Chul Hyun Park, Woo Sung Yoon, Tae Gon Kim, Woong Kim, Ji Sung Yoon, Kyu Chang Won, Hyoung Woo Lee
Diabetes Metab J. 2018;42(4):308-319.   Published online April 27, 2018
DOI: https://doi.org/10.4093/dmj.2017.0076
  • 5,839 View
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  • 10 Web of Science
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AbstractAbstract PDFSupplementary MaterialPubReader   
Background

This study aims to describe the trends in the severity and treatment modality of patients with diabetic foot ulcer (DFU) at a single tertiary referral center in Korea over the last 10 years and compare the outcomes before and after the introduction of a multidisciplinary diabetic foot team.

Methods

In this retrospective observational study, electronic medical records of patients from years 2002 to 2015 at single tertiary referral center were reviewed. Based on the year of first admission, patients were assigned to a group either before or after the year 2012, the year the diabetes team launched.

Results

Of the 338 patients with DFU, 229 were first admitted until the year 2011 (group A), while 109 were first admitted since the year 2012 (group B). Mean age was higher in group B, and ulcer size was larger than those of group A. Whereas duration of diabetes was longer in group B, glycemic control was improved (mean glycosylated hemoglobin, 9.48% vs. 8.50%). The proportion of minor lower extremity amputation (LEA) was increased, but length of hospital stay was decreased (73.7±79.6 days vs. 39.8±36.9 days). As critical ischemic limb increased, the proportion of major LEA was not decreased.

Conclusion

Improved glycemic control, multidisciplinary strategies with prompt surgical treatment resulted in reduced length of hospital stay, but these measures did not reduce major LEAs. The increase in critical ischemic limb may have played a role in the unexpected outcome, and may suggest the need for increased vascular intervention strategies in DFU treatment.

Citations

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  • Life expectancy of patients with diabetic foot sepsis post-lower extremity amputation at a regional hospital in a South African setting. A retrospective cohort study
    Thoriso C. Mokoala, Vhusani Sididzha, Etsumang D. Molefe, Thifhelimbilu E. Luvhengo
    The Surgeon.2024; 22(2): e109.     CrossRef
  • Effect of a multidisciplinary team approach in patients with diabetic foot ulcers on major adverse limb events (MALEs): systematic review and meta-analysis for the development of the Italian guidelines for the treatment of diabetic foot syndrome
    Marco Meloni, Laura Giurato, Luca Monge, Cesare Miranda, Alessia Scatena, Benedetta Ragghianti, Giovanni Antonio Silverii, Cristiana Vermigli, Alessandro De Cassai, Antonio Volpe, Rodolfo Tramonta, Gerardo Medea, Corrado Bordieri, Marco Falcone, Laura Ste
    Acta Diabetologica.2024; 61(5): 543.     CrossRef
  • Health professionals involved in diabetic foot and their tasks in a country without podiatrists: From a Japanese Nationwide Survey
    Yuki Izumi, Hirotaka Onishi, Lawrence A. Lavery
    Wound Repair and Regeneration.2024; 32(5): 630.     CrossRef
  • Effect of Percutaneous Endovascular Angioplasty Combined with Negative Pressure Drainage on the “One-Stop” Treatment of Ischemic Diabetic Foot Ulcer
    Bo Dong, Xixu Wang, Wei Wang, Biao Hong, Jue Wang, Heng Wang, Yun Gu
    Annals of Vascular Surgery.2023; 92: 272.     CrossRef
  • A novel Canadian multidisciplinary acute care pathway for people hospitalised with a diabetic foot ulcer
    Abdelrahman Zamzam, Ann‐Marie McLaren, Emily Ram, Muzammil H. Syed, Sreenath Rave, Suzanne H. Lu, Mohammed Al‐Omran, Charles de Mestral
    International Wound Journal.2023; 20(8): 3331.     CrossRef
  • Impact of multidisciplinary care of diabetic foot infections for inpatients at Campbelltown Hospital
    Timothy Choi, Uchechukwu Levi Osuagwu, Chau Tran, Krupali Bulsari, David Simmons
    BMC Health Services Research.2023;[Epub]     CrossRef
  • Multigene Panel Testing in Turkish Hereditary Cancer Syndrome Patients
    Esra ARSLAN ATES, Ayberk TURKYILMAZ, Ceren ALAVANDA, Ozlem YILDIRIM, Ahmet Ilter GUNEY
    Medeniyet Medical Journal.2022; 37(2): 150.     CrossRef
  • Prediabetes; Prevention and Management
    Asad Ali Mughal, Syed Taha Abbas, Huma Asad, Muhammed Zubair, Nasir Ali Khan, Shehla Naseem, Muhammad Zaman Shaikh
    Pakistan BioMedical Journal.2022; : 03.     CrossRef
  • A systematic review of multidisciplinary teams to reduce major amputations for patients with diabetic foot ulcers
    Jackson Musuuza, Bryn L. Sutherland, Suleyman Kurter, Prakash Balasubramanian, Christie M. Bartels, Meghan B. Brennan
    Journal of Vascular Surgery.2020; 71(4): 1433.     CrossRef
  • The Complexity of Diabetic Foot Management: From Common Care to Best Practice. The Italian Expert Opinion by Delphi Survey
    Elisabetta Salutini, Enrico Brocco, Roberto Da Ros, Luca Monge, Luigi Uccioli, Roberto Anichini
    The International Journal of Lower Extremity Wounds.2020; 19(1): 34.     CrossRef
  • The effect of a multidisciplinary outpatient team approach on outcomes in diabetic foot care: a single center study
    Eline Huizing, Michiel A. Schreve, Willemijn Kortmann, Jan P. Bakker, Jean-Paul P. M. de Vries, Çağdaş Ünlü
    The Journal of Cardiovascular Surgery.2020;[Epub]     CrossRef
Obesity and Metabolic Syndrome
Air Pollution Has a Significant Negative Impact on Intentional Efforts to Lose Weight: A Global Scale Analysis
Morena Ustulin, So Young Park, Sang Ouk Chin, Suk Chon, Jeong-taek Woo, Sang Youl Rhee
Diabetes Metab J. 2018;42(4):320-329.   Published online April 24, 2018
DOI: https://doi.org/10.4093/dmj.2017.0104
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AbstractAbstract PDFPubReader   
Background

Air pollution causes many diseases and deaths. It is important to see how air pollution affects obesity, which is common worldwide. Therefore, we analyzed data from a smartphone application for intentional weight loss, and then we validated them.

Methods

Our analysis was structured in two parts. We analyzed data from a cohort registered to a smartphone application in 10 large cities of the world and matched it with the annual pollution values. We validated these results using daily pollution data in United States and matching them with user information. Body mass index (BMI) variation between final and initial login time was considered as outcome in the first part, and daily BMI in the validation. We analyzed: daily calories intake, daily weight, daily physical activity, geographical coordinates, seasons, age, gender. Weather Underground application programming interface provided daily climatic values. Annual and daily values of particulate matter PM10 and PM2.5 were extracted. In the first part of the analysis, we used 2,608 users and then 995 users located in United States.

Results

Air pollution was highest in Seoul and lowest in Detroit. Users decreased BMI by 2.14 kg/m2 in average (95% confidence interval, −2.26 to −2.04). From a multilevel model, PM10 (β=0.04, P=0.002) and PM2.5 (β=0.08, P<0.001) had a significant negative effect on weight loss when collected per year. The results were confirmed with the validation (βAQI*time=1.5×10–5; P<0.001) by mixed effects model.

Conclusion

This is the first study that shows how air pollution affects intentional weight loss applied on wider area of the world.

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  • What could be the reasons for not losing weight even after following a weight loss program?
    Jyoti Dabas, S. Shunmukha Priya, Akshay Alawani, Praveen Budhrani
    Journal of Health, Population and Nutrition.2024;[Epub]     CrossRef
  • Subchronic exposure to 1,2-naphthoquinone induces adipose tissue inflammation and changes the energy homeostasis of mice, partially due to TNFR1 and TLR4
    Clílton Kraüss de Oliveira Ferreira, Clara Machado Campolim, Olívia Pizetta Zordão, Fernando Moreira Simabuco, Chadi Pellegrini Anaruma, Rodrigo Martins Pereira, Vitor Ferreira Boico, Luiz Guilherme Salvino, Maíra Maftoum Costa, Nathalia Quintero Ruiz, Le
    Toxicology Reports.2023; 11: 10.     CrossRef
  • Effects of Ambient Particulate Matter (PM2.5) Exposure on Calorie Intake and Appetite of Outdoor Workers
    Thavin Kumar Mathana Sundram, Eugenie Sin Sing Tan, Hwee San Lim, Farahnaz Amini, Normina Ahmad Bustami, Pui Yee Tan, Navedur Rehman, Yu Bin Ho, Chung Keat Tan
    Nutrients.2022; 14(22): 4858.     CrossRef
  • Efficiency in reducing air pollutants and healthcare expenditure in the Seoul Metropolitan City of South Korea
    Subal C. Kumbhakar, Jiyeon An, Masoomeh Rashidghalam, Almas Heshmati
    Environmental Science and Pollution Research.2021; 28(20): 25442.     CrossRef
  • Seasonal variation and trends in the Internet searches for losing weight: An infodemiological study
    Ying Teng, Shun-Wei Huang, Zhen Li, Qiao-Mei Xie, Man Zhang, Qiu-Yue Lou, Fang Wang, Yan-Feng Zou
    Obesity Research & Clinical Practice.2020; 14(3): 225.     CrossRef
  • Estimation of health benefits from air quality improvement using the MODIS AOD dataset in Seoul, Korea
    Daeun Kim, Jeongyeong Kim, Jaehwan Jeong, Minha Choi
    Environmental Research.2019; 173: 452.     CrossRef
  • Appropriate Medical Technology in the Era of the 4th Industrial Revolution
    Sang Youl Rhee
    The Korean Journal of Medicine.2019; 94(5): 387.     CrossRef
  • Can Air Pollution Biologically Hinder Efforts to Lose Body Weight?
    Duk-Hee Lee
    Diabetes & Metabolism Journal.2018; 42(4): 282.     CrossRef
Obesity and Metabolic Syndrome
Associations between Body Mass Index and Chronic Kidney Disease in Type 2 Diabetes Mellitus Patients: Findings from the Northeast of Thailand
Sojib Bin Zaman, Naznin Hossain, Muntasirur Rahman
Diabetes Metab J. 2018;42(4):330-337.   Published online August 21, 2018
DOI: https://doi.org/10.4093/dmj.2017.0052
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AbstractAbstract PDFPubReader   
Background

Chronic kidney disease (CKD) has emerged as a public health burden globally. Obesity and long-term hyperglycaemia can initiate the renal vascular complications in patients with type 2 diabetes mellitus (T2DM). This study aimed to investigate the association of body mass index (BMI) with the CKD in patients with T2DM.

Methods

This study has used retrospective medical records, biochemical reports, and anthropometric measurements of 3,580 T2DM patients which were collected between January to December 2015 from a district hospital in Thailand. CKD was defined according to the measurement of estimated glomerular filtration rate (<60 mL/min/1.73 m2). Multiple logistic regression analysis was used to explore the association between BMI and CKD in patients with T2DM.

Results

The mean age of the participants was 60.86±9.67 years, 53.68% had poor glycaemic control, and 45.21% were overweight. About one-in-four (23.26%) T2DM patients had CKD. The mean BMI of non-CKD group was slightly higher (25.30 kg/m2 vs. 24.30 kg/m2) when compared with CKD patients. Multivariable analysis showed that older age, female sex, hypertension, and microalbuminuria were associated with the presence of CKD. No association was observed between CKD and poorly controlled glycosylated hemoglobin or hypercholesterolemia. Adjusted analysis further showed overweight and obesity were negatively associated with CKD (adjusted odds ratio [AOR], 0.73; 95% confidence interval [CI], 0.58 to 0.93) and (AOR, 0.53; 95% CI, 0.35 to 0.81), respectively.

Conclusion

The negative association of BMI with CKD could reflect the reverse causality. Lower BMI might not lead a diabetic patient to develop CKD, but there are possibilities that CKD leads the patient to experience reduced BMI.

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  • Increased Body Mass Index is Independently Associated with Chronic Kidney Disease among People with Type 2 Diabetes
    Vijay Viswanathan, Sivashankari SelvaElavarasan, Satyavani Kumpatla
    Indian Journal of Nephrology.2024; 0: 1.     CrossRef
  • Prevalence and predictors of chronic kidney disease among type 2 diabetic patients worldwide, systematic review and meta-analysis
    Eneyew Talie Fenta, Habitu Birhan Eshetu, Natnael Kebede, Eyob Ketema Bogale, Amare Zewdie, Tadele Derbew Kassie, Tadele Fentabil Anagaw, Elyas Melaku Mazengia, Sintayehu Shiferaw Gelaw
    Diabetology & Metabolic Syndrome.2023;[Epub]     CrossRef
  • Risk Factors of Chronic Kidney Disease (CKD) in Type 2 Diabetes Mellitus (DM) Patients at Dr. Soetomo General Academic Hospital, Surabaya
    Joshua Teofilus Sutadji, Agung Pranoto, Risky Vitria Prasetyo
    JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga.2023; 14(1): 12.     CrossRef
  • Profile of Obesity and Comorbidities and their Correlation among Hemodialysis Patients, Elbasan
    Brunilda Elezi, Skender Topi, Erjona Abazaj
    Open Access Macedonian Journal of Medical Sciences.2022; 10(E): 225.     CrossRef
  • Association of eNOS and MCP-1 Genetic Variants with Type 2 Diabetes and Diabetic Nephropathy Susceptibility: A Case–Control and Meta-Analysis Study
    Priyanka Raina, Ruhi Sikka, Himanshu Gupta, Kawaljit Matharoo, Surinder Kumar Bali, Virinder Singh, AJS Bhanwer
    Biochemical Genetics.2021; 59(4): 966.     CrossRef
  • New Pandemic: Obesity and Associated Nephropathy
    Isha Sharma, Yingjun Liao, Xiaoping Zheng, Yashpal S. Kanwar
    Frontiers in Medicine.2021;[Epub]     CrossRef
  • Associations between obesity, weight change and decreased renal function in Korean type 2 diabetic patients: a longitudinal follow-up study
    Bo-Yeon Kim, Dug-Hyun Choi, Chan-Hee Jung, Ji-Oh Mok, Chul-Hee Kim
    BMC Endocrine Disorders.2021;[Epub]     CrossRef
  • The burden of chronic kidney disease among people with diabetes by insurance schemes: Findings from a primary referral hospital in Thailand
    Sojib Bin Zaman, Rajat Das Gupta, Putthikrai Pramual, Raihan Kabir Khan, Chinakorn Sujimongkol, Naznin Hossain, Mohammad Rifat Haider, Md. Nazmul Karim, Gulam Muhammed Kibria, Sheikh Mohammdad Shariful Islam
    Diabetes Epidemiology and Management.2021; 4: 100026.     CrossRef
  • Association between body mass index and estimated glomerular filtration rate in patients with chronic kidney disease of unknown aetiology in Sri Lanka
    M. R. D. L. Kulathunga, M. A. A. Wijayawardena, Ravi Naidu, S. J. Wimalawansa, A. W. Wijeratne
    Environmental Geochemistry and Health.2020; 42(9): 2645.     CrossRef
  • The prevalence of diabetic chronic kidney disease in adult Greek subjects with type 2 diabetes mellitus: A series from hospital-based diabetes clinics
    Ilias N. Migdalis, Nikolaos Papanas, Athanasios E. Raptis, Ioannis M. Ioannidis, Alexios E. Sotiropoulos, George D. Dimitriadis
    Diabetes Research and Clinical Practice.2020; 166: 108243.     CrossRef
  • Underweight Increases the Risk of End-Stage Renal Diseases for Type 2 Diabetes in Korean Population: Data From the National Health Insurance Service Health Checkups 2009–2017
    Yang-Hyun Kim, Jun Goo Kang, Seong Jin Lee, Kyung-do Han, Sung-Hee Ihm, Kyung-Hwan Cho, Yong-Gyu Park
    Diabetes Care.2020; 43(5): 1118.     CrossRef
  • Prevalence and risk factors of chronic kidney disease among Palestinian type 2 diabetic patients: a cross-sectional study
    Zaher Nazzal, Zakaria Hamdan, Dunia Masri, Oday Abu-Kaf, Mohammad Hamad
    BMC Nephrology.2020;[Epub]     CrossRef
  • Effects of Variability in Blood Pressure, Glucose, and Cholesterol Concentrations, and Body Mass Index on End-Stage Renal Disease in the General Population of Korea
    Mee Kyoung Kim, Kyungdo Han, Hun-Sung Kim, Yong-Moon Park, Hyuk-Sang Kwon, Kun-Ho Yoon, Seung-Hwan Lee
    Journal of Clinical Medicine.2019; 8(5): 755.     CrossRef
Brief Reports
Complications
Effect of Empagliflozin, a Selective Sodium-Glucose Cotransporter 2 Inhibitor, on Kidney and Peripheral Nerves in Streptozotocin-Induced Diabetic Rats
Kyung Ae Lee, Heung Yong Jin, Na Young Lee, Yu Ji Kim, Tae Sun Park
Diabetes Metab J. 2018;42(4):338-342.   Published online April 25, 2018
DOI: https://doi.org/10.4093/dmj.2017.0095
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AbstractAbstract PDFPubReader   

The effect of sodium-glucose cotransporter 2 inhibitors on peripheral nerves and kidneys in diabetes mellitus (DM) remains unexplored. Therefore, this study aimed to explore the effect of empagliflozin in diabetic rats. DM in rats was induced by streptozotocin injection, and diabetic rats were treated with empagliflozin 3 or 10 mg/kg. Following 24-week treatment, response thresholds to four different stimuli were tested and found to be lower in diabetic rats than in normal rats. Empagliflozin significantly prevented hypersensitivity (P<0.05) and the loss of skin intraepidermal nerve fibers, and mesangial matrix expansion in diabetic rats. Results of this study demonstrate the potential therapeutic effects of empagliflozin for the treatment of diabetic peripheral neuropathy and nephropathy.

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  • Effect of empagliflozin in peripheral diabetic neuropathy of patients with type 2 diabetes mellitus
    Sahar Mohamed El-Haggar, Yasser Mostafa Hafez, Amira Mohamed El Sharkawy, Maha Khalifa
    Medicina Clínica.2024; 163(2): 53.     CrossRef
  • Effect of empagliflozin in peripheral diabetic neuropathy of patients with type 2 diabetes mellitus
    Sahar Mohamed El-Haggar, Yasser Mostafa Hafez, Amira Mohamed El Sharkawy, Maha Khalifa
    Medicina Clínica (English Edition).2024; 163(2): 53.     CrossRef
  • Neuroprotective Effects of Sodium-Glucose Cotransporter-2 (SGLT2) Inhibitors (Gliflozins) on Diabetes-Induced Neurodegeneration and Neurotoxicity: A Graphical Review
    Mina Gholami, Natalie Coleman-Fuller, Mahsa Salehirad, Sepideh Darbeheshti, Majid Motaghinejad
    International Journal of Preventive Medicine.2024;[Epub]     CrossRef
  • A Review of Recent Pharmacological Advances in the Management of Diabetes-Associated Peripheral Neuropathy
    Osman Syed, Predrag Jancic, Nebojsa Nick Knezevic
    Pharmaceuticals.2023; 16(6): 801.     CrossRef
  • Renal intrinsic cells remodeling in diabetic kidney disease and the regulatory effects of SGLT2 Inhibitors
    Wenwen Guo, Han Li, Yixuan Li, Wen Kong
    Biomedicine & Pharmacotherapy.2023; 165: 115025.     CrossRef
  • A systematic review on renal effects of SGLT2 inhibitors in rodent models of diabetic nephropathy
    Aqsa Ashfaq, Myriam Meineck, Andrea Pautz, Ebru Arioglu-Inan, Julia Weinmann-Menke, Martin C. Michel
    Pharmacology & Therapeutics.2023; 249: 108503.     CrossRef
  • The impact of canagliflozin on the risk of neuropathy events: A post-hoc exploratory analysis of the CREDENCE trial
    Jinlan Liao, Amy Kang, Chao Xia, Tamara Young, Gian Luca Di Tanna, Clare Arnott, Carol Pollock, Arun V. Krishnan, Rajiv Agarwal, George Bakris, David M. Charytan, Dick de Zeeuw, Hiddo J.L. Heerspink, Adeera Levin, Bruce Neal, David C. Wheeler, Hong Zhang,
    Diabetes & Metabolism.2022; 48(4): 101331.     CrossRef
  • Sodium Glucose Cotransporter-2 Inhibitor Protects Against Diabetic Neuropathy and Nephropathy in Modestly Controlled Type 2 Diabetes: Follow-Up Study
    Fukashi Ishibashi, Aiko Kosaka, Mitra Tavakoli
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Protective effect of empagliflozin on gentamicin-induced acute renal injury via regulation of SIRT1/NF-κB signaling pathway
    Sandy R. Botros, Asmaa I. Matouk, Aliaa Anter, Mohamed M.A. Khalifa, Gehan H. Heeba
    Environmental Toxicology and Pharmacology.2022; 94: 103907.     CrossRef
  • Empagliflozin mitigates type 2 diabetes-associated peripheral neuropathy: a glucose-independent effect through AMPK signaling
    Noha F. Abdelkader, Marawan A. Elbaset, Passant E. Moustafa, Sherehan M. Ibrahim
    Archives of Pharmacal Research.2022; 45(7): 475.     CrossRef
  • Pathogenesis and Treatment of Diabetic Peripheral Neuropathy
    Seon Mee Kang
    The Journal of Korean Diabetes.2022; 23(4): 222.     CrossRef
  • Empagliflozin and neohesperidin protect against methotrexate-induced renal toxicity via suppression of oxidative stress and inflammation in male rats
    Adel T. Osman, Souty M.Z. Sharkawi, Mohamed I.A. Hassan, Amira M. Abo-youssef, Ramadan A.M. Hemeida
    Food and Chemical Toxicology.2021; 155: 112406.     CrossRef
  • Effect of exenatide on peripheral nerve excitability in type 2 diabetes
    Tushar Issar, Natalie C.G. Kwai, Ann M. Poynten, Ria Arnold, Kerry-Lee Milner, Arun V. Krishnan
    Clinical Neurophysiology.2021; 132(10): 2532.     CrossRef
  • Effectiveness of Empagliflozin With Vitamin D Supplementation in Peripheral Neuropathy in Type 2 Diabetic Patients
    Sanjana Mehta, Parminder Nain, Bimal K Agrawal, Rajinder P Singh, Jaspreet Kaur, Sabyasachi Maity, Aniruddha Bhattarcharjee, Jagannadha Peela, Shreya Nauhria, Samal Nauhria
    Cureus.2021;[Epub]     CrossRef
  • Targeting oxidative stress, proinflammatory cytokines, apoptosis and toll like receptor 4 by empagliflozin to ameliorate bleomycin-induced lung fibrosis
    Ahmed M. Kabel, Remon S. Estfanous, Majed M. Alrobaian
    Respiratory Physiology & Neurobiology.2020; 273: 103316.     CrossRef
  • Empagliflozin reduces high glucose-induced oxidative stress and miR-21-dependent TRAF3IP2 induction and RECK suppression, and inhibits human renal proximal tubular epithelial cell migration and epithelial-to-mesenchymal transition
    Nitin A. Das, Andrea J. Carpenter, Anthony Belenchia, Annayya R. Aroor, Makoto Noda, Ulrich Siebenlist, Bysani Chandrasekar, Vincent G. DeMarco
    Cellular Signalling.2020; 68: 109506.     CrossRef
  • Differential Effects of Empagliflozin on Microvascular Complications in Murine Models of Type 1 and Type 2 Diabetes
    Stephanie A. Eid, Phillipe D. O’Brien, Lucy M. Hinder, John M. Hayes, Faye E. Mendelson, Hongyu Zhang, Lixia Zeng, Katharina Kretzler, Samanthi Narayanan, Steven F. Abcouwer, Frank C. Brosius, Subramaniam Pennathur, Masha G. Savelieff, Eva L. Feldman
    Biology.2020; 9(11): 347.     CrossRef
  • Pre-treatment with Empagliflozin ameliorates Cisplatin induced acute kidney injury by suppressing apoptosis
    Maaly A. Abd Elmaaboud, Ahmed M. Kabel, Mohamed Elrashidy
    Journal of Applied Biomedicine.2019; 17(1): 90.     CrossRef
  • Effects of ticagrelor, empagliflozin and tamoxifen against experimentally-induced vascular reactivity defects in rats in vivo and in vitro
    Yasmin Moustafa Ahmed, Basim Anwar Shehata Messiha, Mahmoud El-Sayed El-Daly, Ali Ahmed Abo-Saif
    Pharmacological Reports.2019; 71(6): 1034.     CrossRef
  • SGLT2 inhibition with empagliflozin attenuates myocardial oxidative stress and fibrosis in diabetic mice heart
    Chenguang Li, Jie Zhang, Mei Xue, Xiaoyu Li, Fei Han, Xiangyang Liu, Linxin Xu, Yunhong Lu, Ying Cheng, Ting Li, Xiaochen Yu, Bei Sun, Liming Chen
    Cardiovascular Diabetology.2019;[Epub]     CrossRef
  • Empagliflozin Contributes to Polyuria via Regulation of Sodium Transporters and Water Channels in Diabetic Rat Kidneys
    Sungjin Chung, Soojeong Kim, Mina Son, Minyoung Kim, Eun Sil Koh, Seok Joon Shin, Seung-Hyun Ko, Ho-Shik Kim
    Frontiers in Physiology.2019;[Epub]     CrossRef
Others
Serum Soluble Epidermal Growth Factor Receptor Level Increase in Patients Newly Diagnosed with Type 2 Diabetes Mellitus
Ji Min Kim, Sorim Choung, Kyong Hye Joung, Ju Hee Lee, Hyun Jin Kim, Bon Jeong Ku
Diabetes Metab J. 2018;42(4):343-347.   Published online May 2, 2018
DOI: https://doi.org/10.4093/dmj.2017.0082
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AbstractAbstract PDFPubReader   

We analyzed circulating soluble epidermal growth factor receptor (sEGFR) levels in humans. Serum sEGFR levels were higher in subjects with newly diagnosed type 2 diabetes mellitus compared with controls. Serum sEGFR was positively correlated with glycosylated hemoglobin and serum glucose and negatively correlated with serum insulin and C-peptide levels.

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    Cellular & Molecular Biology Letters.2024;[Epub]     CrossRef
  • A Pilot Genome-Wide Association Study Identifies Novel Markers of Metabolic Syndrome in Patients with Psoriasis
    Seung-Min Oh, Su-Kang Kim, Hye-Jin Ahn, Ki-Heon Jeong
    Annals of Dermatology.2023; 35(4): 285.     CrossRef
  • Effect of cholesterol-lowering agents on soluble epidermal growth factor receptor level in type 2 diabetes and hypercholesterolemia
    Jun Choul Lee, Kyong Hye Joung, Ji Min Kim, Seon Mee Kang, Hyun Jin Kim, Bon Jeong Ku
    Medicine.2022; 101(34): e30287.     CrossRef
  • Soluble EGFR, a hepatokine, and adipsin, an adipokine, are biomarkers correlated with distinct aspects of insulin resistance in type 2 diabetes subjects
    Mayu Kyohara, Jun Shirakawa, Tomoko Okuyama, Yu Togashi, Ryota Inoue, Jinghe Li, Daisuke Miyashita, Yasuo Terauchi
    Diabetology & Metabolic Syndrome.2020;[Epub]     CrossRef
  • Epidermal growth factor protects against myocardial ischaemia reperfusion injury through activating Nrf2 signalling pathway
    Jun Ma, Ge Jin
    Free Radical Research.2019; 53(3): 313.     CrossRef
Letter
Letter: Serum Levels of PCSK9 Are Associated with Coronary Angiographic Severity in Patients with Acute Coronary Syndrome (Diabetes Metab J 2018;42:207-14)
Jin Hwa Kim
Diabetes Metab J. 2018;42(4):348-349.   Published online August 21, 2018
DOI: https://doi.org/10.4093/dmj.2018.0135
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PDFPubReader   

Citations

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  • PCSK9 gene participates in the development of primary dyslipidemias
    D Matías-Pérez, AD Pérez-Santiago, MA Sánchez Medina, JJ Alpuche Osorno, IA García-Montalvo
    Balkan Journal of Medical Genetics.2021; 24(1): 5.     CrossRef
Response
Response: Serum Levels of PCSK9 Are Associated with Coronary Angiographic Severity in Patients with Acute Coronary Syndrome (Diabetes Metab J 2018;42:207-14)
Sung Woo Kim, Keun-Gyu Park
Diabetes Metab J. 2018;42(4):350-352.   Published online August 21, 2018
DOI: https://doi.org/10.4093/dmj.2018.0138
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PDFPubReader   

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    Biomedicines.2022; 10(8): 1961.     CrossRef
  • PCSK9: Associated with cardiac diseases and their risk factors?
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  • Butein Synergizes with Statin to Upregulate Low-Density Lipoprotein Receptor ThroughHNF1α-Mediated PCSK9 Inhibition in HepG2 Cells
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    Journal of Medicinal Food.2020; 23(10): 1102.     CrossRef
Erratum
Corrigendum
Corrigendum: Figure Correction. Primary Cilia as a Signaling Platform for Control of Energy Metabolism
Min-Seon Kim
Diabetes Metab J. 2018;42(4):354-354.   Published online August 21, 2018
DOI: https://doi.org/10.4093/dmj.2018.0115
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Diabetes Metab J : Diabetes & Metabolism Journal
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