Citations

Citations to this article as recorded by  

• Cyclo His‐Pro Attenuates Muscle Degeneration in Murine Myopathy Models
  Alessia De Masi, Nadège Zanou, Keno Strotjohann, Dohyun Lee, Tanes I. Lima, Xiaoxu Li, Jongsu Jeon, Nicolas Place, Hoe‐Yune Jung, Johan Auwerx
  Advanced Science.2024;[Epub]     CrossRef

Obesity resulting from the delivery of an excess amount of energy to adipose tissue from glucose or free fatty acids is associated with insulin resistance and adipose tissue inflammation. Reactive oxygen species (ROS) have been implicated as contributors to both the onset and the progression of insulin resistance. ROS can be generated by overloading the mitochondrial oxidative phosphorylation system, and also by nicotinamide adenine dinucleotide phosphate oxidases (NOX) produced by either adipocytes, which only produce NOX4, or by macrophages, which produce mainly NOX2. The source of the ROS might differ in the early, intermediate and late stages of obesity, switching from NOX4-dependence in the early phases to NOX2-dependence, in the intermediate phase, and transiting to mitochondria-dependence later in the time course of obesity. Thus, depending on the stage of obesity, ROS can be generated by three distinct mechanisms: i.e., NOX4, NOX2, and mitochondria. In this review, we will discuss whether NOX4-, NOX2-, and/or mitochondria-derived ROS is/are causal in the onset of adipocyte insulin resistance as obesity progresses. Moreover, we will review the pathophysiological roles of NOX4, NOX2, and mitochondria-derived ROS on adipose tissue inflammation.

Citations

Citations to this article as recorded by  

• The Relationship of Alcohol Consumption and Drinking Pattern to the Risk of Glomerular Hyperfiltration in Middle-aged Japanese Men: The Kansai Healthcare Study
  Mikiko Shibata, Kyoko Kogawa Sato, Hideo Koh, Izumi Shibata, Kaori Okamura, Yuka Takeuchi, Keiko Oue, Michio Morimoto, Tomoshige Hayashi
  Journal of Epidemiology.2024; 34(3): 137.     CrossRef
• Monoamine oxidase mediated oxidative stress: a potential molecular and biochemical crux in the pathogenesis of obesity
  J. P. Shirley Niveta, Cordelia Mano John, Sumathy Arockiasamy
  Molecular Biology Reports.2024;[Epub]     CrossRef
• The obesity-autophagy-cancer axis: Mechanistic insights and therapeutic perspectives
  Amir Barzegar Behrooz, Marco Cordani, Alessandra Fiore, Massimo Donadelli, Joseph W. Gordon, Daniel J. Klionsky, Saeid Ghavami
  Seminars in Cancer Biology.2024; 99: 24.     CrossRef
• Molecular and pathophysiological relationship between obesity and chronic inflammation in the manifestation of metabolic dysfunctions and their inflammation‑mediating treatment options (Review)
  Fani-Niki Varra, Michail Varras, Viktoria-Konstantina Varra, Panagiotis Theodosis‑Nobelos
  Molecular Medicine Reports.2024;[Epub]     CrossRef
• Pathogenesis and management of diabetic gastroparesis: An updated clinically oriented review
  Srikar Uppaluri, Manisha Ashok Jain, Hira Ali, Jay Shingala, Dhruti Amin, Trisha Ajwani, Irum Fatima, Neil Patel, Nirja Kaka, Yashendra Sethi, Nitin Kapoor
  Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2024; 18(3): 102994.     CrossRef
• The advent of RNA-based therapeutics for metabolic syndrome and associated conditions: a comprehensive review of the literature
  Helen Ye Rim Huang, Sarah Badar, Mohammad Said, Siddiqah Shah, Hareesha Rishab Bharadwaj, Krishna Ramamoorthy, Maen Monketh Alrawashdeh, Faaraea Haroon, Jawad Basit, Sajeel Saeed, Narjiss Aji, Gary Tse, Priyanka Roy, Mainak Bardhan
  Molecular Biology Reports.2024;[Epub]     CrossRef
• The complex interplay between oxinflammation, mitochondrial dysfunction and lipotoxicity: Focus on their role in the pathogenesis of skeletal muscle insulin resistance and modulation by dietary fatty acids
  Angelina Passaro, Juana Maria Sanz, Nenad Naumovski, Domenico Sergi
  Advances in Redox Research.2024; 11: 100100.     CrossRef
• The Interplay between Obesity and Inflammation
  Ilinca Savulescu-Fiedler, Razvan Mihalcea, Serban Dragosloveanu, Cristian Scheau, Radu Octavian Baz, Ana Caruntu, Andreea-Elena Scheau, Constantin Caruntu, Serban Nicolae Benea
  Life.2024; 14(7): 856.     CrossRef
• Dietary fatty acid pattern and its association with metabolic profile among overweight and obese adults
  Reyhaneh Mokhtari Hemami, Mahdieh Abbasalizad Farhangi, Mohammad Dehghan Rouzi, Fatemeh Abdi
  BMC Endocrine Disorders.2024;[Epub]     CrossRef
• Extracellular vesicles regulate the transmission of insulin resistance and redefine noncommunicable diseases
  Biao Li, Wan Li, Tiancai Liu, Longying Zha
  Frontiers in Molecular Biosciences.2023;[Epub]     CrossRef
• Oxidative stress in metabolic diseases: current scenario and therapeutic relevance
  Satish K. Raut, Madhu Khullar
  Molecular and Cellular Biochemistry.2023; 478(1): 185.     CrossRef
• Rainbow Trout (Oncorhynchus mykiss) as Source of Multifunctional Peptides with Antioxidant, ACE and DPP-IV Inhibitory Activities
  Martina Bartolomei, Janna Cropotova, Carlotta Bollati, Kristine Kvangarsnes, Lorenza d’Adduzio, Jianqiang Li, Giovanna Boschin, Carmen Lammi
  Nutrients.2023; 15(4): 829.     CrossRef
• Current Status of Obesity: Protective Role of Catechins
  Tanisha Basu, Ashley Selman, Arubala P. Reddy, P. Hemachandra Reddy
  Antioxidants.2023; 12(2): 474.     CrossRef
• Advanced Oxidation Protein Products Contribute to Chronic-Kidney-Disease-Induced Adipose Inflammation through Macrophage Activation
  Nanaka Arimura, Hiroshi Watanabe, Hiromasa Kato, Tadashi Imafuku, Takehiro Nakano, Miyu Sueyoshi, Mayuko Chikamatsu, Kai Tokumaru, Taisei Nagasaki, Hitoshi Maeda, Motoko Tanaka, Kazutaka Matsushita, Toru Maruyama
  Toxins.2023; 15(3): 179.     CrossRef
• The Role of Oxidative Stress Enhanced by Adiposity in Cardiometabolic Diseases
  Iwona Świątkiewicz, Marcin Wróblewski, Jarosław Nuszkiewicz, Paweł Sutkowy, Joanna Wróblewska, Alina Woźniak
  International Journal of Molecular Sciences.2023; 24(7): 6382.     CrossRef
• Understanding the Impact of Obesity on Ageing in the Radiance of DNA Metabolism
  S.G. Chowdhury, S. Misra, Parimal Karmakar
  The Journal of nutrition, health and aging.2023; 27(5): 314.     CrossRef
• Cross-talk between insulin resistance and nitrogen species in hypoxia leads to deterioration of tissue and homeostasis
  Priyanshy Sharma, V. Sri Swetha Victoria, P. Praneeth Kumar, Sarbani Karmakar, Mudduluru Swetha, Amala Reddy
  International Immunopharmacology.2023; 122: 110472.     CrossRef
• Mechanisms of Formation and Persistence of IgE Products and Potential Innovative Means of Therapy for Allergic Pathologies
  D. B. Chudakov, M. V. Konovalova, M. A. Streltsova, O. A. Shustova, A. A. Generalov, G. V. Fattakhova
  Applied Biochemistry and Microbiology.2023; 59(6): 754.     CrossRef
• Mechanism and application of Lactobacillus in type 2 diabetes-associated periodontitis
  Sisi Chen, Yuhan Zhang
  Frontiers in Public Health.2023;[Epub]     CrossRef
• Mechanisms of Formation and Persistence of Ige Products and Potential Innovative Means of Therapy for Allergic Pathologies
  D. B. Chudakov, M. V. Konovalova, M. A. Streltsova, O. A. Shustova, A. A. Generalov, G. V. Fattakhova
  Прикладная биохимия и микробиология.2023; 59(6): 538.     CrossRef
• Activated monocytes as a therapeutic target to attenuate vascular inflammation and lower cardiovascular disease-risk in patients with type 2 diabetes: A systematic review of preclinical and clinical studies
  Siphamandla R. Ngcobo, Bongani B. Nkambule, Tawanda M. Nyambuya, Kabelo Mokgalaboni, Aviwe Ntsethe, Vuyolwethu Mxinwa, Khanyisani Ziqubu, Yonela Ntamo, Thembeka A. Nyawo, Phiwayinkosi V. Dludla
  Biomedicine & Pharmacotherapy.2022; 146: 112579.     CrossRef
• Genomic Analysis of Visceral Fat Accumulation in Holstein Cows
  Larissa C. Novo, Ligia Cavani, Pablo Pinedo, Pedro Melendez, Francisco Peñagaricano
  Frontiers in Genetics.2022;[Epub]     CrossRef
• Regulation of immune cell function by nicotinamide nucleotide transhydrogenase
  Thomas Regan, Rachel Conway, Leena P. Bharath
  American Journal of Physiology-Cell Physiology.2022; 322(4): C666.     CrossRef
• d-Allulose Ameliorates Hyperglycemia Through IRE1α Sulfonation-RIDD-Sirt1 Decay Axis in the Skeletal Muscle
  Hwa-Young Lee, Geum-Hwa Lee, The-Hiep Hoang, Seon-Ah Park, Juwon Lee, Junghyun Lim, Soonok Sa, Go Eun Kim, Jung Sook Han, Junghyun Kim, Han-Jung Chae
  Antioxidants & Redox Signaling.2022; 37(4-6): 229.     CrossRef
• Impact of physical exercise and caloric restriction in patients with type 2 diabetes: Skeletal muscle insulin resistance and mitochondrial dysfunction as ideal therapeutic targets
  Sinenhlanhla X.H. Mthembu, Sithandiwe E. Mazibuko-Mbeje, Khanyisani Ziqubu, Thembeka A. Nyawo, Nnini Obonye, Tawanda M. Nyambuya, Bongani B. Nkambule, Sonia Silvestri, Luca Tiano, Christo J.F. Muller, Phiwayinkosi V. Dludla
  Life Sciences.2022; 297: 120467.     CrossRef
• The burden of overweight: Higher body mass index, but not vital exhaustion, is associated with higher DNA damage and lower DNA repair capacity
  Judy Fieres, Marvin Fischer, Christine Sauter, Maria Moreno-Villanueva, Alexander Bürkle, Petra H. Wirtz
  DNA Repair.2022; 114: 103323.     CrossRef
• The Disordered Amino Terminus of the Circadian Enzyme Nocturnin Modulates Its NADP(H) Phosphatase Activity by Changing Protein Dynamics
  Anushka C. Wickramaratne, Li Li, Jesse B. Hopkins, Lukasz A. Joachimiak, Carla B. Green
  Biochemistry.2022; 61(11): 1091.     CrossRef
• Oxidative stress and obesity
  Maja Malenica, Neven Meseldžić
  Arhiv za farmaciju.2022; 72(2): 166.     CrossRef
• Transcriptomic analysis of Simpson Golabi Behmel Syndrome cells during differentiation exhibit BAT-like function
  M. Colitti, U. Ali, M. Wabitsch, D. Tews
  Tissue and Cell.2022; : 101822.     CrossRef
• Vitamin E supplementation improves testosterone, glucose- and lipid-related metabolism in women with polycystic ovary syndrome: a meta-analysis of randomized clinical trials
  Sebastián Yalle-Vásquez, Karem Osco-Rosales, Wendy Nieto-Gutierrez, Vicente Benites-Zapata, Faustino R. Pérez-López, Christoper A. Alarcon-Ruiz
  Gynecological Endocrinology.2022; 38(7): 548.     CrossRef
• The Immune Response in Adipocytes and Their Susceptibility to Infection: A Possible Relationship with Infectobesity
  Orestes López-Ortega, Nidia Carolina Moreno-Corona, Victor Javier Cruz-Holguin, Luis Didier Garcia-Gonzalez, Addy Cecilia Helguera-Repetto, Mirza Romero-Valdovinos, Haruki Arevalo-Romero, Leticia Cedillo-Barron, Moisés León-Juárez
  International Journal of Molecular Sciences.2022; 23(11): 6154.     CrossRef
• Participation of Magnesium in the Secretion and Signaling Pathways of Insulin: an Updated Review
  Stéfany Rodrigues de Sousa Melo, Loanne Rocha dos Santos, Tamires da Cunha Soares, Bruna Emanuele Pereira Cardoso, Thaline Milany da Silva Dias, Jennifer Beatriz Silva Morais, Mickael de Paiva Sousa, Thayanne Gabryelle Visgueira de Sousa, Nilmara Cunha da
  Biological Trace Element Research.2022; 200(8): 3545.     CrossRef
• Nrf2a dependent and independent effects of early life exposure to 3,3’-dichlorobiphenyl (PCB-11) in zebrafish (Danio rerio)
  Monika A. Roy, Charlotte K. Gridley, Sida Li, Yeonhwa Park, Alicia R. Timme-Laragy
  Aquatic Toxicology.2022; 249: 106219.     CrossRef
• Highly active antiretroviral therapy-silver nanoparticle conjugate interacts with neuronal and glial cells and alleviates anxiety-like behaviour in streptozotocin-induced diabetic rats
  Sodiq Kolawole Lawal, Samuel Oluwaseun Olojede, Ayobami Dare, Oluwaseun Samuel Faborode, Sheu Oluwadare Sulaiman, Edwin Coleridge Naidu, Carmen Olivia Rennie, Onyemaechi Okpara Azu
  IBRO Neuroscience Reports.2022; 13: 57.     CrossRef
• Vitamin C attenuates predisposition to high-fat diet-induced metabolic dysregulation in GLUT10-deficient mouse model
  Chung-Lin Jiang, Chang-Yu Tsao, Yi-Ching Lee
  Genes & Nutrition.2022;[Epub]     CrossRef
• Adipose Tissue Aging and Metabolic Disorder, and the Impact of Nutritional Interventions
  Xiujuan Wang, Meihong Xu, Yong Li
  Nutrients.2022; 14(15): 3134.     CrossRef
• Production of Reactive Oxygen Species by Epicardial Adipocytes Is Associated with an Increase in Postprandial Glycemia, Postprandial Insulin, and a Decrease in Serum Adiponectin in Patients with Severe Coronary Atherosclerosis
  Natalia V. Naryzhnaya, Olga A. Koshelskaya, Irina V. Kologrivova, Tatiana E. Suslova, Olga A. Kharitonova, Sergey L. Andreev, Alexander S. Gorbunov, Boris K. Kurbatov, Alla A. Boshchenko
  Biomedicines.2022; 10(8): 2054.     CrossRef
• Aberrant mitochondrial homeostasis at the crossroad of musculoskeletal ageing and non-small cell lung cancer
  Konstantinos Prokopidis, Panagiotis Giannos, Oliver C. Witard, Daniel Peckham, Theocharis Ispoglou, Ajay Pratap Singh
  PLOS ONE.2022; 17(9): e0273766.     CrossRef
• Nutraceutical Prevention of Diabetic Complications—Focus on Dicarbonyl and Oxidative Stress
  Mark F. McCarty, James J. DiNicolantonio, James H. O’Keefe
  Current Issues in Molecular Biology.2022; 44(9): 4314.     CrossRef
• Fructose promotes more than glucose the adipocytic differentiation of pig mesenchymal stem cells
  Francisco Campos‐Maldonado, María L. González‐Dávalos, Enrique Piña, Miriam Aracely Anaya‐Loyola, Armando Shimada, Alfredo Varela‐Echavarria, Ofelia Mora
  Journal of Food Biochemistry.2022;[Epub]     CrossRef
• Understanding the effect of obesity on papillary thyroid cancer: is there a need for tailored diagnostic and therapeutic management?
  Antonio Matrone, Alessio Basolo, Ferruccio Santini, Rossella Elisei
  Expert Review of Endocrinology & Metabolism.2022; 17(6): 475.     CrossRef
• The Role of Inflammation as a Preponderant Risk Factor in Cardiovascular Diseases
  Rodrigo Damián García, Joana Antonela Asensio, Diahann Jeanette Perdicaro, María de los Ángeles Peral
  Current Vascular Pharmacology.2022; 20(3): 244.     CrossRef
• Synthesis and Catalytic Studies of Nanoalloy Particles Based on Bismuth, Silver, and Rhenium
  Konrad Wojtaszek, Katarzyna Skibińska, Filip Cebula, Tomasz Tokarski, Marc Escribà-Gelonch, Volker Hessel, Marek Wojnicki
  Metals.2022; 12(11): 1819.     CrossRef
• Endothelium-Derived Relaxing Factors and Endothelial Function: A Systematic Review
  Francesco Nappi, Antonio Fiore, Joyce Masiglat, Teresa Cavuoti, Michela Romandini, Pierluigi Nappi, Sanjeet Singh Avtaar Singh, Jean-Paul Couetil
  Biomedicines.2022; 10(11): 2884.     CrossRef
• MicroRNAs in the Regulation of NADPH Oxidases in Vascular Diabetic and Ischemic Pathologies: A Case for Alternate Inhibitory Strategies?
  Sean R. Wallace, Patrick J. Pagano, Damir Kračun
  Antioxidants.2022; 12(1): 70.     CrossRef
• Potential Roles of Adipocyte Extracellular Vesicle–Derived miRNAs in Obesity-Mediated Insulin Resistance
  Yujeong Kim, Ok-Kyung Kim
  Advances in Nutrition.2021; 12(2): 566.     CrossRef
• Mesenchymal stem cell conditioned medium ameliorates diabetic serum‐induced insulin resistance in 3T3‐L1 cells
  Avinash Sanap, Ramesh Bhonde, Kalpana Joshi
  Chronic Diseases and Translational Medicine.2021; 7(1): 47.     CrossRef
• F13A1 transglutaminase expression in human adipose tissue increases in acquired excess weight and associates with inflammatory status of adipocytes
  M. T. Kaartinen, M. Arora, S. Heinonen, A. Hang, A. Barry, J. Lundbom, A. Hakkarainen, N. Lundholm, A. Rissanen, J. Kaprio, K. H. Pietiläinen
  International Journal of Obesity.2021; 45(3): 577.     CrossRef
• Obesity and the prevention of thyroid cancer: Impact of body mass index and weight change on developing thyroid cancer – Pooled results of 24 million cohorts
  Mohanad R. Youssef, Adin S.C. Reisner, Abdallah S. Attia, Mohamed Hosny Hussein, Mahmoud Omar, Anna LaRussa, Carlos A. Galvani, Mohamed Aboueisha, Mohamed Abdelgawad, Eman Ali Toraih, Gregory W. Randolph, Emad Kandil
  Oral Oncology.2021; 112: 105085.     CrossRef
• Thioredoxin deficiency exacerbates vascular dysfunction during diet‐induced obesity in small mesenteric artery in mice
  Shannon Dunn, Robert H. Hilgers, Kumuda C. Das
  Microcirculation.2021;[Epub]     CrossRef
• Protein Digests and Pure Peptides from Chia Seed Prevented Adipogenesis and Inflammation by Inhibiting PPARγ and NF-κB Pathways in 3T3L-1 Adipocytes
  Mariana Grancieri, Hércia Stampini Duarte Martino, Elvira Gonzalez de Mejia
  Nutrients.2021; 13(1): 176.     CrossRef
• The Interplay Between Adipose Tissue and Vasculature: Role of Oxidative Stress in Obesity
  Yawen Zhou, Huige Li, Ning Xia
  Frontiers in Cardiovascular Medicine.2021;[Epub]     CrossRef
• Peri-renal adipose inflammation contributes to renal dysfunction in a non-obese prediabetic rat model: Role of anti-diabetic drugs
  Safaa H. Hammoud, Ibrahim AlZaim, Nahed Mougharbil, Sahar Koubar, Ali H. Eid, Assaad A. Eid, Ahmed F. El-Yazbi
  Biochemical Pharmacology.2021; 186: 114491.     CrossRef
• Hydrogen Nano-Bubble Water Suppresses ROS Generation, Adipogenesis, and Interleukin-6 Secretion in Hydrogen-Peroxide- or PMA-Stimulated Adipocytes and Three-Dimensional Subcutaneous Adipose Equivalents
  Li Xiao, Nobuhiko Miwa
  Cells.2021; 10(3): 626.     CrossRef
• Redox Homeostasis in Pancreatic β-Cells: From Development to Failure
  Štěpánka Benáková, Blanka Holendová, Lydie Plecitá-Hlavatá
  Antioxidants.2021; 10(4): 526.     CrossRef
• Htd2 deficiency-associated suppression of α-lipoic acid production provokes mitochondrial dysfunction and insulin resistance in adipocytes
  Mengqi Zeng, Jie Xu, Zhengyi Zhang, Xuan Zou, Xueqiang Wang, Ke Cao, Weiqiang Lv, Yuting Cui, Jiangang Long, Zhihui Feng, Jiankang Liu
  Redox Biology.2021; 41: 101948.     CrossRef
• Nutraceutical, Dietary, and Lifestyle Options for Prevention and Treatment of Ventricular Hypertrophy and Heart Failure
  Mark F. McCarty
  International Journal of Molecular Sciences.2021; 22(7): 3321.     CrossRef
• Contribution of Adipose Tissue Oxidative Stress to Obesity-Associated Diabetes Risk and Ethnic Differences: Focus on Women of African Ancestry
  Pamela A. Nono Nankam, Télesphore B. Nguelefack, Julia H. Goedecke, Matthias Blüher
  Antioxidants.2021; 10(4): 622.     CrossRef
• Effects of different models of sucrose intake on the oxidative status of the uterus and ovary of rats
  Joanna Sadowska, Wioleta Dudzińska, Izabela Dziaduch, Mahmoud A.O. Dawood
  PLOS ONE.2021; 16(5): e0251789.     CrossRef
• Oxidative stress in oocyte aging and female reproduction
  Ling Wang, Jinhua Tang, Lei Wang, Feng Tan, Huibin Song, Jiawei Zhou, Fenge Li
  Journal of Cellular Physiology.2021; 236(12): 7966.     CrossRef
• Temporal correlation of morphological and biochemical changes with the recruitment of different mechanisms of reactive oxygen species formation during human SW872 cell adipogenic differentiation
  Mara Fiorani, Rita De Matteis, Barbara Canonico, Giulia Blandino, Alessandro Mazzoli, Mariele Montanari, Andrea Guidarelli, Orazio Cantoni
  BioFactors.2021; 47(5): 837.     CrossRef
• Antioxidant and anti-inflammatory properties of gamma- oryzanol attenuates insulin resistance by increasing GLUT- 4 expression in skeletal muscle of obese animals
  Letícia Mattei, Fabiane Valentini Francisqueti-Ferron, Jéssica Leite Garcia, Artur Junio Togneri Ferron, Carol Cristina Vágula de Almeida Silva, Cristina Schmitt Gregolin, Erika Tiemi Nakandakare-Maia, Janaína das Chagas Paixão Silva, Fernando Moreto, Igo
  Molecular and Cellular Endocrinology.2021; 537: 111423.     CrossRef
• Serum Bilirubin Levels in Overweight and Obese Individuals: The Importance of Anti-Inflammatory and Antioxidant Responses
  Lovro Žiberna, Zala Jenko-Pražnikar, Ana Petelin
  Antioxidants.2021; 10(9): 1352.     CrossRef
• The level of reactive oxygen species production by adipocytes of epicardial adipose tissue is associated with an increase in postprandial glycemia in patients with severe coronary atherosclerosis
  O. A. Koshelskaya, N. V. Naryzhnaya, I. V. Kologrivova, T. E. Suslova, O. A. Kharitonova, V. V. Evtushenko, S. L. Andreev, A. S. Gorbunov, A. A. Gudkova
  The Siberian Journal of Clinical and Experimental Medicine.2021; 36(3): 59.     CrossRef
• Exercise training results in depot-specific adaptations to adipose tissue mitochondrial function
  Amy E. Mendham, Steen Larsen, Cindy George, Kevin Adams, Jon Hauksson, Tommy Olsson, Melony C. Fortuin-de Smidt, Pamela A. Nono Nankam, Olah Hakim, Louise M. Goff, Carmen Pheiffer, Julia H. Goedecke
  Scientific Reports.2020;[Epub]     CrossRef
• Oxidative stress resulting from the removal of endogenous catalase induces obesity by promoting hyperplasia and hypertrophy of white adipocytes
  Su-Kyung Shin, Hyun-Woo Cho, Seung-Eun Song, Seung-Soon Im, Jae-Hoon Bae, Dae-Kyu Song
  Redox Biology.2020; 37: 101749.     CrossRef
• Pathogenic Role of Air Pollution Particulate Matter in Cardiometabolic Disease: Evidence from Mice and Humans
  Timoteo Marchini, Andreas Zirlik, Dennis Wolf
  Antioxidants & Redox Signaling.2020; 33(4): 263.     CrossRef
• Fumarate and oxidative stress synergize to promote stability of C/EBP homologous protein in the adipocyte
  Allison M. Manuel, Michael D. Walla, Margaret T. Dorn, Ross M. Tanis, Gerardo G. Piroli, Norma Frizzell
  Free Radical Biology and Medicine.2020; 148: 70.     CrossRef
• TNF-α G-308A genetic variants, serum CRP-hs concentration and DNA damage in obese women
  Marta Włodarczyk, Michał Ciebiera, Grażyna Nowicka
  Molecular Biology Reports.2020; 47(2): 855.     CrossRef
• Lipolysis modulates the biosynthesis of inflammatory lipid mediators derived from linoleic acid in adipose tissue of periparturient dairy cows
  G. Andres Contreras, Jenne De Koster, Jonas de Souza, Juliana Laguna, Vengai Mavangira, Rahul K. Nelli, Jeff Gandy, Adam L. Lock, Lorraine M. Sordillo
  Journal of Dairy Science.2020; 103(2): 1944.     CrossRef
• Dietary Fat and Cancer—Which Is Good, Which Is Bad, and the Body of Evidence
  Bianka Bojková, Pawel J. Winklewski, Magdalena Wszedybyl-Winklewska
  International Journal of Molecular Sciences.2020; 21(11): 4114.     CrossRef
• Adipose tissue macrophages: Unique polarization and bioenergetics in obesity
  Heather L. Caslin, Monica Bhanot, W. Reid Bolus, Alyssa H. Hasty
  Immunological Reviews.2020; 295(1): 101.     CrossRef
• Conditioned medium of adipose derived Mesenchymal Stem Cells reverse insulin resistance through downregulation of stress induced serine kinases
  Avinash Sanap, Ramesh Bhonde, Kalpana Joshi
  European Journal of Pharmacology.2020; 881: 173215.     CrossRef
• Quercetin metabolites from Hibiscus sabdariffa contribute to alleviate glucolipotoxicity-induced metabolic stress in vitro
  María Herranz-López, Mariló Olivares-Vicente, Esther Rodríguez Gallego, Jose Antonio Encinar, Almudena Pérez-Sánchez, Verónica Ruiz-Torres, Jorge Joven, Enrique Roche, Vicente Micol
  Food and Chemical Toxicology.2020; 144: 111606.     CrossRef
• Elastin-derived peptide VGVAPG decreases differentiation of mouse embryo fibroblast (3T3-L1) cells into adipocytes
  Konrad A. Szychowski, Bartosz Skóra, Jakub Tobiasz, Jan Gmiński
  Adipocyte.2020; 9(1): 234.     CrossRef
• Pharmacological potential of the combination of Salvia miltiorrhiza (Danshen) and Carthamus tinctorius (Honghua) for diabetes mellitus and its cardiovascular complications
  John O. Orgah, Shuang He, Yule Wang, Miaomiao Jiang, Yuefei Wang, Emmanuel A. Orgah, Yajun Duan, Buchang Zhao, Boli Zhang, Jihong Han, Yan Zhu
  Pharmacological Research.2020; 153: 104654.     CrossRef
• Microbiota-Mitochondria Inter-Talk: A Potential Therapeutic Strategy in Obesity and Type 2 Diabetes
  Teresa Vezza, Zaida Abad-Jiménez, Miguel Marti-Cabrera, Milagros Rocha, Víctor Manuel Víctor
  Antioxidants.2020; 9(9): 848.     CrossRef
• Transglutaminases and Obesity in Humans: Association of F13A1 to Adipocyte Hypertrophy and Adipose Tissue Immune Response
  Mari T. Kaartinen, Mansi Arora, Sini Heinonen, Aila Rissanen, Jaakko Kaprio, Kirsi H. Pietiläinen
  International Journal of Molecular Sciences.2020; 21(21): 8289.     CrossRef
• Phytosterols: Nutritional Health Players in the Management of Obesity and Its Related Disorders
  Teresa Vezza, Francisco Canet, Aranzazu M. de Marañón, Celia Bañuls, Milagros Rocha, Víctor Manuel Víctor
  Antioxidants.2020; 9(12): 1266.     CrossRef
• Metabolic programming of macrophage functions and pathogens control
  Sue-jie Koo, Nisha J. Garg
  Redox Biology.2019; 24: 101198.     CrossRef
• Effects of bariatric surgery on telomere length and T-cell aging
  F. Jongbloed, R. W. J. Meijers, J. N. M. IJzermans, R. A. Klaassen, M. E. T. Dollé, S. van den Berg, M. G. H. Betjes, R. W. F. de Bruin, E. van der Harst, N. H. R. Litjens
  International Journal of Obesity.2019; 43(11): 2189.     CrossRef
• Shared pathways for neuroprogression and somatoprogression in neuropsychiatric disorders
  Gerwyn Morris, Basant K. Puri, Adam J. Walker, Michael Maes, Andre F. Carvalho, Chiara C. Bortolasci, Ken Walder, Michael Berk
  Neuroscience & Biobehavioral Reviews.2019; 107: 862.     CrossRef
• Adipose oxidative stress and protein carbonylation
  Amy K. Hauck, Yimao Huang, Ann V. Hertzel, David A. Bernlohr
  Journal of Biological Chemistry.2019; 294(4): 1083.     CrossRef
• Modulatory functions of bioactive fruits, vegetables and spices in adipogenesis and angiogenesis
  Priyanka Sarkar, Kavitha Thirumurugan
  Journal of Functional Foods.2019; 53: 318.     CrossRef
• Spontaneous ketonuria and risk of incident diabetes: a 12 year prospective study
  Gyuri Kim, Sang-Guk Lee, Byung-Wan Lee, Eun Seok Kang, Bong-Soo Cha, Ele Ferrannini, Yong-ho Lee, Nam H. Cho
  Diabetologia.2019; 62(5): 779.     CrossRef
• Obesity, DNA Damage, and Development of Obesity-Related Diseases
  Marta Włodarczyk, Grażyna Nowicka
  International Journal of Molecular Sciences.2019; 20(5): 1146.     CrossRef
• Weight change is significantly associated with risk of thyroid cancer: A nationwide population-based cohort study
  Hyemi Kwon, Kyung-Do Han, Cheol-Young Park
  Scientific Reports.2019;[Epub]     CrossRef
• The Role of NADPH Oxidases in the Etiology of Obesity and Metabolic Syndrome: Contribution of Individual Isoforms and Cell Biology
  Evan DeVallance, Yao Li, Michael J. Jurczak, Eugenia Cifuentes-Pagano, Patrick J. Pagano
  Antioxidants & Redox Signaling.2019; 31(10): 687.     CrossRef
• Phenolic compounds as natural and multifunctional anti-obesity agents: A review
  Celia Rodríguez-Pérez, Antonio Segura-Carretero, María del Mar Contreras
  Critical Reviews in Food Science and Nutrition.2019; 59(8): 1212.     CrossRef
• Oxygenic metabolism in nutritional obesity induced by olive oil. The influence of vitamin C
  Eraci Drehmer, Mari Ángeles Navarro-Moreno, Sandra Carrera, Vincent M. Villar, Mari Luz Moreno
  Food & Function.2019; 10(6): 3567.     CrossRef
• High Glucose Level Impairs Human Mature Bone Marrow Adipocyte Function Through Increased ROS Production
  Tareck Rharass, Stéphanie Lucas
  Frontiers in Endocrinology.2019;[Epub]     CrossRef
• Redox TRPs in diabetes and diabetic complications: Mechanisms and pharmacological modulation
  Pratik Adhya, Shyam Sunder Sharma
  Pharmacological Research.2019; 146: 104271.     CrossRef
• Linking Arrhythmias and Adipocytes: Insights, Mechanisms, and Future Directions
  Maria A. Pabon, Kevin Manocha, Jim W. Cheung, James C. Lo
  Frontiers in Physiology.2018;[Epub]     CrossRef
• Strawberry extract attenuates oxidative stress in 3T3-L1 cells
  Tamara Y. Forbes-Hernández, Sadia Afrin, Danila Cianciosi, Piera Pia Manna, Jiaojiao Zhang, Massimiliano Gasparrini, Patricia Reboredo-Rodríguez
  Journal of Berry Research.2018; 8(3): 193.     CrossRef
• The mitochondrial unfolded protein response and mitohormesis: a perspective on metabolic diseases
  Hyon-Seung Yi, Joon Young Chang, Minho Shong
  Journal of Molecular Endocrinology.2018; 61(3): R91.     CrossRef
• Emerging Roles for Adipose Tissue in Cardiovascular Disease
  Elizabeth E. Ha, Robert C. Bauer
  Arteriosclerosis, Thrombosis, and Vascular Biology.2018;[Epub]     CrossRef
• miR-199a-3p regulates brown adipocyte differentiation through mTOR signaling pathway
  Yao Gao, Yan Cao, Xianwei Cui, Xingyun Wang, Yahui Zhou, Fangyan Huang, Xing Wang, Juan Wen, Kaipeng Xie, Pengfei Xu, Xirong Guo, Lianghui You, Chenbo Ji
  Molecular and Cellular Endocrinology.2018; 476: 155.     CrossRef
• Reduced expression of Twist 1 is protective against insulin resistance of adipocytes and involves mitochondrial dysfunction
  Sumei Lu, Hong Wang, Rui Ren, Xiaohong Shi, Yanmei Zhang, Wanshan Ma
  Scientific Reports.2018;[Epub]     CrossRef
• Zanthoxylum ailanthoides Suppresses Oleic Acid‐Induced Lipid Accumulation through an Activation of LKB1/AMPK Pathway in HepG2 Cells
  Eun-Bin Kwon, Myung-Ji Kang, Soo-Yeon Kim, Yong-Moon Lee, Mi-Kyeong Lee, Heung Joo Yuk, Hyung Won Ryu, Su Ui Lee, Sei-Ryang Oh, Dong-Oh Moon, Hyun-Sun Lee, Mun-Ock Kim, Shao-Hsuan Kao
  Evidence-Based Complementary and Alternative Medicine.2018;[Epub]     CrossRef
• Supplementation of Lactobacillus plantarum Improves Markers of Metabolic Dysfunction Induced by a High Fat Diet
  Alice Martinic, Javad Barouei, Zach Bendiks, Darya Mishchuk, Dustin D. Heeney, Roy Martin, Maria L. Marco, Carolyn M. Slupsky
  Journal of Proteome Research.2018; 17(8): 2790.     CrossRef
• The novel NADPH oxidase 4 selective inhibitor GLX7013114 counteracts human islet cell death in vitro
  Xuan Wang, Andris Elksnis, Per Wikström, Erik Walum, Nils Welsh, Per-Ola Carlsson, Harald H. H. W. Schmidt
  PLOS ONE.2018; 13(9): e0204271.     CrossRef
• Involvement of adipose tissue inflammation and dysfunction in virus-induced type 1 diabetes
  James C Needell, Madalyn N Brown, Danny Zipris
  Journal of Endocrinology.2018; 238(1): 61.     CrossRef
• Autophagy as an emerging target in cardiorenal metabolic disease: From pathophysiology to management
  Yingmei Zhang, Adam T. Whaley-Connell, James R. Sowers, Jun Ren
  Pharmacology & Therapeutics.2018; 191: 1.     CrossRef
• Inflammation and Oxidative Stress in an Obese State and the Protective Effects of Gallic Acid
  Phiwayinkosi V. Dludla, Bongani B. Nkambule, Babalwa Jack, Zibusiso Mkandla, Tinashe Mutize, Sonia Silvestri, Patrick Orlando, Luca Tiano, Johan Louw, Sithandiwe E. Mazibuko-Mbeje
  Nutrients.2018; 11(1): 23.     CrossRef
• Adipocyte-Specific Deficiency of NADPH Oxidase 4 Delays the Onset of Insulin Resistance and Attenuates Adipose Tissue Inflammation in Obesity
  Laura J. Den Hartigh, Mohamed Omer, Leela Goodspeed, Shari Wang, Tomasz Wietecha, Kevin D. O’Brien, Chang Yeop Han
  Arteriosclerosis, Thrombosis, and Vascular Biology.2017; 37(3): 466.     CrossRef
• Novel lipid-mimetic prodrugs delivering active compounds to adipose tissue
  Andrea Mattarei, Andrea Rossa, Veronica Bombardelli, Michele Azzolini, Martina La Spina, Cristina Paradisi, Mario Zoratti, Lucia Biasutto
  European Journal of Medicinal Chemistry.2017; 135: 77.     CrossRef
• Combined metformin and insulin treatment reverses metabolically impaired omental adipogenesis and accumulation of 4-hydroxynonenal in obese diabetic patients
  Morana Jaganjac, Shamma Almuraikhy, Fatima Al-Khelaifi, Mashael Al-Jaber, Moataz Bashah, Nayef A. Mazloum, Kamelija Zarkovic, Neven Zarkovic, Georg Waeg, Wael Kafienah, Mohamed A. Elrayess
  Redox Biology.2017; 12: 483.     CrossRef
• A Novel Index Using Soluble CD36 Is Associated with the Prevalence of Type 2 Diabetes Mellitus: Comparison Study with Triglyceride-Glucose Index
  Ho Jin Kim, Jun Sung Moon, Il Rae Park, Joong Hee Kim, Ji Sung Yoon, Kyu Chang Won, Hyoung Woo Lee
  Endocrinology and Metabolism.2017; 32(3): 375.     CrossRef
• Xanthine oxidase inhibition by febuxostat attenuates stress-induced hyperuricemia, glucose dysmetabolism, and prothrombotic state in mice
  Maimaiti Yisireyili, Motoharu Hayashi, Hongxian Wu, Yasuhiro Uchida, Koji Yamamoto, Ryosuke Kikuchi, Mohammad Shoaib Hamrah, Takayuki Nakayama, Xian Wu Cheng, Tadashi Matsushita, Shigeo Nakamura, Toshimitsu Niwa, Toyoaki Murohara, Kyosuke Takeshita
  Scientific Reports.2017;[Epub]     CrossRef
• Differential Effect of Sucrose and Fructose in Combination with a High Fat Diet on Intestinal Microbiota and Kidney Oxidative Stress
  Adriana Rosas-Villegas, Mónica Sánchez-Tapia, Azalia Avila-Nava, Victoria Ramírez, Armando Tovar, Nimbe Torres
  Nutrients.2017; 9(4): 393.     CrossRef
• Neovascular deterioration, impaired NADPH oxidase and inflammatory cytokine expression in adipose-derived multipotent cells from subjects with metabolic syndrome
  Wilfredo Oliva-Olivera, Said Lhamyani, Leticia Coín-Aragüez, Daniel Castellano-Castillo, Juan Alcaide-Torres, Elena María Yubero-Serrano, Rajaa El Bekay, Francisco José Tinahones
  Metabolism.2017; 71: 132.     CrossRef
• Fatty acid binding protein 4/aP2-dependent BLT1R expression and signaling
  Ann V. Hertzel, Hongliang Xu, Michael Downey, Nicholas Kvalheim, David A. Bernlohr
  Journal of Lipid Research.2017; 58(7): 1354.     CrossRef
• Metformin prevents glucotoxicity by alleviating oxidative and ER stress–induced CD36 expression in pancreatic beta cells
  Jun Sung Moon, Udayakumar Karunakaran, Suma Elumalai, In-Kyu Lee, Hyoung Woo Lee, Yong-Woon Kim, Kyu Chang Won
  Journal of Diabetes and its Complications.2017; 31(1): 21.     CrossRef
• Teneligliptin, a dipeptidyl peptidase-4 inhibitor, attenuated pro-inflammatory phenotype of perivascular adipose tissue and inhibited atherogenesis in normoglycemic apolipoprotein-E-deficient mice
  Hotimah Masdan Salim, Daiju Fukuda, Yasutomi Higashikuni, Kimie Tanaka, Yoichiro Hirata, Shusuke Yagi, Takeshi Soeki, Michio Shimabukuro, Masataka Sata
  Vascular Pharmacology.2017; 96-98: 19.     CrossRef
• Obesity-induced vascular dysfunction and arterial stiffening requires endothelial cell arginase 1
  Anil Bhatta, Lin Yao, Zhimin Xu, Haroldo A. Toque, Jijun Chen, Reem T. Atawia, Abdelrahman Y. Fouda, Zsolt Bagi, Rudolf Lucas, Ruth B. Caldwell, Robert W. Caldwell
  Cardiovascular Research.2017; 113(13): 1664.     CrossRef
• Change in serum albumin concentration is inversely and independently associated with risk of incident metabolic syndrome
  Sang-Man Jin, Yong Joo Hong, Jae Hwan Jee, Ji Cheol Bae, Kyu Yeon Hur, Moon-Kyu Lee, Jae Hyeon Kim
  Metabolism.2016; 65(11): 1629.     CrossRef

Ageing is the most significant risk factor for a range of prevalent diseases, including cancer, cardiovascular disease, and diabetes. Accordingly, interventions are needed for delaying or preventing disorders associated with the ageing process, i.e., promotion of healthy ageing. Calorie restriction is the only nongenetic and the most robust approach to slow the process of ageing in evolutionarily divergent species, ranging from yeasts, worms, and flies to mammals. Although it has been known for more than 80 years that calorie restriction increases lifespan, a mechanistic understanding of this phenomenon remains elusive. Yeast silent information regulator 2 (Sir2), the founding member of the sirtuin family of protein deacetylases, and its mammalian homologue Sir2-like protein 1 (SIRT1), have been suggested to promote survival and longevity of organisms. SIRT1 exerts protective effects against a number of age-associated disorders. Caloric restriction increases both Sir2 and SIRT1 activity. This review focuses on the mechanistic insights between caloric restriction and Sir2/SIRT1 activation. A number of molecular links, including nicotinamide adenine dinucleotide, nicotinamide, biotin, and related metabolites, are suggested to be the most important conduits mediating caloric restriction-induced Sir2/SIRT1 activation and lifespan extension.

Citations

Citations to this article as recorded by  

• Caloric Restriction Can Ameliorate Postoperative Cognitive Dysfunction by Upregulating the Expression of Sirt1, MeCP2 and BDNF in the Hippocampal CA1 Region of Aged C57BL/6 Mice
  Lan Wei, Qiang Tao, Minmin Yao, Zhimeng Zhao, Shengjin Ge
  Brain Sciences.2023; 13(3): 462.     CrossRef
• Metabolic Syndrome and Cardiac Remodeling Due to Mitochondrial Oxidative Stress Involving Gliflozins and Sirtuins
  Raúl Lelio Sanz, Felipe Inserra, Sebastián García Menéndez, Luciana Mazzei, León Ferder, Walter Manucha
  Current Hypertension Reports.2023; 25(6): 91.     CrossRef
• The Tricarboxylic Acid Cycle as a Central Regulator of the Rate of Aging: Implications for Metabolic Interventions
  Jonathan M. Borkum
  Advanced Biology.2023;[Epub]     CrossRef
• Metabolic Reprogramming by Reduced Calorie Intake or Pharmacological Caloric Restriction Mimetics for Improved Cancer Immunotherapy
  Erwan Eriau, Juliette Paillet, Guido Kroemer, Jonathan G. Pol
  Cancers.2021; 13(6): 1260.     CrossRef
• SGLT2 Inhibitors as Calorie Restriction Mimetics: Insights on Longevity Pathways and Age-Related Diseases
  Caroline W S Hoong, Marvin W J Chua
  Endocrinology.2021;[Epub]     CrossRef
• A comprehensive insight into the potential effects of resveratrol supplementation on SIRT-1: A systematic review
  Marziyeh Najafi, Omid Nikpayam, Omid Mohammad Tavakoli-Rouzbehani, Shahab Papi, Atefeh Amrollahi bioky, Elham sadat Ahmadiani, Golbon Sohrab
  Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2021; 15(5): 102224.     CrossRef
• Antiaging and Antioxidant Bioactivities of Asteraceae Plant Fractions on the Cellular Functions of the Yeast Schizosaccharomyces pombe
  Rika Indri Astuti, Muhammad Eka Prastya, Irmanida Batubara, Eka Budiarti, Aulia Ilmiyawati, Mounir Tilaoui
  Advances in Pharmacological and Pharmaceutical Sciences.2021; 2021: 1.     CrossRef
• Principles of brain aging: Status and challenges of modeling human molecular changes in mice
  Verena Kluever, Eugenio F. Fornasiero
  Ageing Research Reviews.2021; 72: 101465.     CrossRef
• Role of NRF2 and Sirtuin activators in COVID-19
  Hasnat Khan, Shivangi Patel, Anuradha Majumdar
  Clinical Immunology.2021; 233: 108879.     CrossRef
• Role of acetylation in nonalcoholic fatty liver disease: a focus on SIRT1 and SIRT3
  Fatiha Nassir
  Exploration of Medicine.2020; 1(4): 248.     CrossRef
• NAD metabolism in aging and cancer
  John WR Kincaid, Nathan A Berger
  Experimental Biology and Medicine.2020; 245(17): 1594.     CrossRef
• Cyclin‐dependent kinase Pho85p and its cyclins are involved in replicative lifespan through multiple pathways in yeast
  Toshio Nakajima, Tsubasa Maruhashi, Takaaki Morimatsu, Yukio Mukai
  FEBS Letters.2020; 594(7): 1166.     CrossRef
• SIRT1 Allele Frequencies in Depressed Patients of European Descent in Russia
  Lyubomir I. Aftanas, Maksim S. Anisimenko, Darya A. Berdyugina, Aleksandr Yu. Garanin, Vladimir N. Maximov, Mikhail I. Voevoda, Natalya M. Vyalova, Nikolay A. Bokhan, Svetlana A. Ivanova, Konstantin V. Danilenko, Sergei P. Kovalenko
  Frontiers in Genetics.2019;[Epub]     CrossRef
• Resveratrol attenuates myocardial hypoxia/reoxygenation-induced cell apoptosis through DJ-1-mediated SIRT1-p53 pathway
  Rui-Yuan Xu, Xing-Wang Xu, Yi-Zhang Deng, Zhao-Xia Ma, Xiao-Ran Li, Le Zhao, Le-Jia Qiu, Hao-Yue Liu, He-Ping Chen
  Biochemical and Biophysical Research Communications.2019; 514(2): 401.     CrossRef
• The pathobiology of polycystic kidney disease from a metabolic viewpoint
  Luis Fernando Menezes, Gregory G. Germino
  Nature Reviews Nephrology.2019; 15(12): 735.     CrossRef
• Six Weeks of Calorie Restriction Improves Body Composition and Lipid Profile in Obese and Overweight Former Athletes
  Joanna Hołowko, Małgorzata Magdalena Michalczyk, Adam Zając, Maja Czerwińska-Rogowska, Karina Ryterska, Marcin Banaszczak, Karolina Jakubczyk, Ewa Stachowska
  Nutrients.2019; 11(7): 1461.     CrossRef
• Sirtuins in gamete biology and reproductive physiology: emerging roles and therapeutic potential in female and male infertility
  Carla Tatone, Giovanna Di Emidio, Arcangelo Barbonetti, Gaspare Carta, Alberto M Luciano, Stefano Falone, Fernanda Amicarelli
  Human Reproduction Update.2018; 24(3): 267.     CrossRef
• Is there a role of H2S in mediating health span benefits of caloric restriction?
  Li Theng Ng, Jan Gruber, Philip Keith Moore
  Biochemical Pharmacology.2018; 149: 91.     CrossRef
• Sirtuins and Accelerated Aging in Scleroderma
  Anne E. Wyman, Sergei P. Atamas
  Current Rheumatology Reports.2018;[Epub]     CrossRef
• Comparison of Calorie-Restricted Diet and Resveratrol Supplementation on Anthropometric Indices, Metabolic Parameters, and Serum Sirtuin-1 Levels in Patients With Nonalcoholic Fatty Liver Disease: A Randomized Controlled Clinical Trial
  Somayyeh Asghari, Mohammad Asghari-Jafarabadi, Mohammad-Hossein Somi, Seyed-Mostafa Ghavami, Maryam Rafraf
  Journal of the American College of Nutrition.2018; 37(3): 223.     CrossRef
• Amino Acid Restriction Triggers Angiogenesis via GCN2/ATF4 Regulation of VEGF and H2S Production
  Alban Longchamp, Teodelinda Mirabella, Alessandro Arduini, Michael R. MacArthur, Abhirup Das, J. Humberto Treviño-Villarreal, Christopher Hine, Issam Ben-Sahra, Nelson H. Knudsen, Lear E. Brace, Justin Reynolds, Pedro Mejia, Ming Tao, Gaurav Sharma, Rui W
  Cell.2018; 173(1): 117.     CrossRef
• Recent insights into the cellular and molecular determinants of aging
  Linhao Ruan, Xi Zhang, Rong Li
  Journal of Cell Science.2018;[Epub]     CrossRef
• SIRT1 Activity in Peripheral Blood Mononuclear Cells Correlates with Altered Lung Function in Patients with Chronic Obstructive Pulmonary Disease
  Valeria Conti, Graziamaria Corbi, Valentina Manzo, Paola Malangone, Carolina Vitale, Angelantonio Maglio, Roberta Cotugno, Damiano Capaccio, Luigi Marino, Carmine Selleri, Cristiana Stellato, Amelia Filippelli, Alessandro Vatrella, Francesca Danesi
  Oxidative Medicine and Cellular Longevity.2018;[Epub]     CrossRef
• Sirt1: Role Under the Condition of Ischemia/Hypoxia
  Xiaofei Meng, Jin Tan, Mengmeng Li, Shuling Song, Yuyang Miao, Qiang Zhang
  Cellular and Molecular Neurobiology.2017; 37(1): 17.     CrossRef
• Salidroside protects PC12 cells from Aβ1–40-induced cytotoxicity by regulating the nicotinamide phosphoribosyltransferase signaling pathway
  Xujiao Huang, Sanli Xing, Chuan Chen, Zhihua Yu, Jiulin Chen
  Molecular Medicine Reports.2017; 16(3): 2700.     CrossRef
• Combined Salt and Caloric Restrictions: Potential Adverse Outcomes
  Tsuyoshi Homma, Mika Homma, Yuefei Huang, Korapat Mayurasakorn, Nurul Mahamad Rodi, Anis Amalina Abdul Hamid, Shelley Hurwitz, Tham Yao, Gail K. Adler, Luminita H. Pojoga, Gordon H. Williams, Jose R. Romero
  Journal of the American Heart Association.2017;[Epub]     CrossRef
• Hyperglycemic Stress and Carbon Stress in Diabetic Glucotoxicity
  Xiaoting Luo, Jinzi Wu, Siqun Jing, Liang-Jun Yan
  Aging and disease.2016; 7(1): 90.     CrossRef
• Endothelial SIRT1 prevents adverse arterial remodeling by facilitating HERC2-mediated degradation of acetylated LKB1
  Bo Bai, Andy W.C. Man, Kangmin Yang, Yumeng Guo, Cheng Xu, Hung-Fat Tse, Weiping Han, Maria Bloksgaard, Jo G.R. De Mey, Paul M. Vanhoutte, Aimin Xu, Yu Wang
  Oncotarget.2016; 7(26): 39065.     CrossRef
• Circadian clocks govern calorie restriction—mediated life span extension through BMAL1‐ and IGF‐1‐dependent mechanisms
  Sonal A. Patel, Amol Chaudhari, Richa Gupta, Nikkhil Velingkaar, Roman V. Kondratov
  The FASEB Journal.2016; 30(4): 1634.     CrossRef
• Nutrigenomics at the Interface of Aging, Lifespan, and Cancer Prevention
  Gabriela Riscuta
  The Journal of Nutrition.2016; 146(10): 1931.     CrossRef
• Haploinsufficiency of the Myc regulator Mtbp extends survival and delays tumor development in aging mice
  Brian C. Grieb, Kelli Boyd, Ramkrishna Mitra, Christine M. Eischen
  Aging.2016; 8(10): 2590.     CrossRef
• Protein Modifications as Manifestations of Hyperglycemic Glucotoxicity in Diabetes and Its Complications
  Hong Zheng, Jinzi Wu, Zhen Jin, Liang-Jun Yan
  Biochemistry Insights.2016; 9: BCI.S36141.     CrossRef
• Nutritional limitation in early postnatal life and its effect on aging and longevity in rodents
  Kallie Davis, Douja Chamseddine, James M. Harper
  Experimental Gerontology.2016; 86: 84.     CrossRef
• 1,4-Dihydropyridines Active on the SIRT1/AMPK Pathway Ameliorate Skin Repair and Mitochondrial Function and Exhibit Inhibition of Proliferation in Cancer Cells
  Sergio Valente, Paolo Mellini, Francesco Spallotta, Vincenzo Carafa, Angela Nebbioso, Lucia Polletta, Ilaria Carnevale, Serena Saladini, Daniela Trisciuoglio, Chiara Gabellini, Maria Tardugno, Clemens Zwergel, Chiara Cencioni, Sandra Atlante, Sébastien Mo
  Journal of Medicinal Chemistry.2016; 59(4): 1471.     CrossRef
• Involvement of Daphnia pulicaria Sir2 in regulating stress response and lifespan
  Charles A. Schumpert, Craig Anderson, Jeffry L. Dudycha, Rekha C. Patel
  Aging.2016; 8(2): 402.     CrossRef
• Metformin Restores Parkin-Mediated Mitophagy, Suppressed by Cytosolic p53
  Young Song, Woo Lee, Yong-ho Lee, Eun Kang, Bong-Soo Cha, Byung-Wan Lee
  International Journal of Molecular Sciences.2016; 17(1): 122.     CrossRef
• Are sirtuins markers of ovarian aging?
  Jinjin Zhang, Li Fang, Zhiyong Lu, Jiaqiang Xiong, Meng Wu, Liangyan Shi, Aiyue Luo, Shixuan Wang
  Gene.2016; 575(2): 680.     CrossRef
• Coadjuvants in the Diabetic Complications: Nutraceuticals and Drugs with Pleiotropic Effects
  Thiago Pereira, Fabio Pimenta, Marcella Porto, Marcelo Baldo, Bianca Campagnaro, Agata Gava, Silvana Meyrelles, Elisardo Vasquez
  International Journal of Molecular Sciences.2016; 17(8): 1273.     CrossRef
• Extended longevity and survivorship during amino-acid starvation in a DrosophilaSir2mutant heterozygote
  Jennifer D. Slade, Brian E. Staveley, A. Civetta
  Genome.2016; 59(5): 311.     CrossRef
• Resveratrol inhibits doxorubicin-induced cardiotoxicity via sirtuin 1 activation in H9c2 cardiomyocytes
  Mi-Hua Liu, Jian Shan, Jian Li, Yuan Zhang, Xiao-Long Lin
  Experimental and Therapeutic Medicine.2016; 12(2): 1113.     CrossRef
• Effect of caloric restriction on the SIRT1/mTOR signaling pathways in senile mice
  Lina Ma, Wen Dong, Rong Wang, Yun Li, Baolei Xu, Jingshuang Zhang, Zhiwei Zhao, Yulan Wang
  Brain Research Bulletin.2015; 116: 67.     CrossRef
• Metformin prevents aggressive ovarian cancer growth driven by high-energy diet: similarity with calorie restriction
  Zaid Al-Wahab, Ismail Mert, Calvin Tebbe, Jasdeep Chhina, Miriana Hijaz, Robert T. Morris, Rouba Ali-Fehmi, Shailendra Giri, Adnan R. Munkarah, Ramandeep Rattan
  Oncotarget.2015; 6(13): 10908.     CrossRef
• Restriction on an Energy-Dense Diet Improves Markers of Metabolic Health and Cellular Aging in Mice Through Decreasing Hepatic mTOR Activity
  Anke Schloesser, Graeme Campbell, Claus-Christian Glüer, Gerald Rimbach, Patricia Huebbe
  Rejuvenation Research.2015; 18(1): 30.     CrossRef
• Calorie Restriction Prevents Metabolic Aging Caused by Abnormal SIRT1 Function in Adipose Tissues
  Cheng Xu, Yu Cai, Pengcheng Fan, Bo Bai, Jie Chen, Han-Bing Deng, Chi-Ming Che, Aimin Xu, Paul M. Vanhoutte, Yu Wang
  Diabetes.2015; 64(5): 1576.     CrossRef

Oxidative stress has been paid increasing attention to as an important causative factor for diabetic vascular complications. Among possible various sources, accumulating evidence has indicated that NAD(P)H oxidase may be the most important source for reactive oxygen species production in diabetic vascular tissues. The mechanisms underlying activation and up-regulation of NAD(P)H oxidase has been supposed to be mediated by high glucose-induced protein kinase C (PKC) activation. In this review article, activation of local renin-angiotensin II system induced by chymase activation is also shown to amplify such a PKC-dependent activation of NAD(P)H oxidase. Additionally, human evidence showing the beneficial effect of antioxidants on diabetic vascular complications. Bilirubin has been recognized as a strong endogenous antioxidant. Here markedly lower prevalence of vascular complications is shown in diabetic patients with Gilbert syndrome, a congenital hyperbilirubinemia, as well as reduced markers of oxidative stress and inflammation. Lastly, statin, angiotensin II receptor blocker, chymase inhibitor, bilirubin and biliverdin, PKC β isoform inhibitor, and glucagon-like peptide-1 analog, are shown to serve as antioxidants and have some beneficial effect on diabetic vascular complications, via inhibiting PKC-NAD(P)H oxidase activation, supporting the notion that this mechanism may be an effective therapeutic target for preventing diabetic vascular complications.

Citations

Citations to this article as recorded by  

• The effects of whey protein on anthropometric parameters, resting energy expenditure, oxidative stress, and appetite in overweight/obese women with type 2 diabetes mellitus: A randomized placebo controlled clinical trial
  Maryam Nouri, Bahram Pourghassem Gargari, Zahra Ghasempour, Vahideh Sadra, Mohammad Asghari Jafarabadi, Arvin Babaei, Pedram Tajfar, Ali Tarighat-Esfanjani
  International Journal of Diabetes in Developing Countries.2024; 44(1): 155.     CrossRef
• Rhodanine-benzamides as potential hits for α-amylase enzyme inhibitors and radical (DPPH and ABTS) scavengers
  Samuel Attah Egu, Irfan Ali, Khalid Mohammed Khan, Sridevi Chigurupati, Urooj Qureshi, Uzma Salar, Zaheer Ul-Haq, Suliman A. Almahmoud, Shatha Ghazi Felemban, Mohsin Ali, Muhammad Taha
  Molecular Diversity.2024;[Epub]     CrossRef
• Research Progress of FGF-21 and CVAI in Type 2 Diabetic Kidney Disease
  央宗 才巴
  Advances in Clinical Medicine.2023; 13(07): 12056.     CrossRef
• Is Subcutaneous Rifamycin Application Superior to Saline Application in Hip Hemiarthroplasty?
  Malik Çelik, Nezih Ziroğlu, Alkan Bayrak
  Bakirkoy Tip Dergisi / Medical Journal of Bakirkoy.2023; 19(2): 186.     CrossRef
• In pursuit of incorporation of markers of oxidative stress in traditional biochemical panels in clinical Chemistry: A risk assessment step in diagnosis and biotherapy
  John Ibhagbemien Anetor, Chukwuemelie Zedech Uche, Gloria Oiyahumen Anetor
  American Journal of Biopharmacy and Pharmaceutical Sciences.2022; 2: 1.     CrossRef
• Pathophysiologic Mechanisms and Potential Biomarkers in Diabetic Kidney Disease
  Chan-Young Jung, Tae-Hyun Yoo
  Diabetes & Metabolism Journal.2022; 46(2): 181.     CrossRef
• p38 MAPK Inhibitor (SB203580) and Metformin Reduces Aortic Protein Carbonyl and Inflammation in Non-obese Type 2 Diabetic Rats
  Nuttikarn Nokkaew, Podsawee Mongkolpathumrat, Ruttanapong Junsiri, Supawit Jindaluang, Nichagron Tualamun, Niya Manphatthanakan, Nareumon Saleesee, Marisa Intasang, Jantira Sanit, Punyanuch Adulyaritthikul, Kantapich Kongpol, Sarawut Kumphune, Nitirut Ner
  Indian Journal of Clinical Biochemistry.2021; 36(2): 228.     CrossRef
• Resveratrol-Elicited PKC Inhibition Counteracts NOX-Mediated Endothelial to Mesenchymal Transition in Human Retinal Endothelial Cells Exposed to High Glucose
  Roberta Giordo, Gheyath K. Nasrallah, Anna Maria Posadino, Francesco Galimi, Giampiero Capobianco, Ali Hussein Eid, Gianfranco Pintus
  Antioxidants.2021; 10(2): 224.     CrossRef
• BIOLOGICAL ACTIVE COMPONENTS OF SILENE TOMENTELLA AND THEIR PHARMACOLOGICAL PROPERTIES
  Ugiloy Yusufovna Yusupova, Nurmurod Sheralievich Ramazonov, Khairulla Mamadievich Bobakulov, Feruza Rustamovna Egamova, Vladimir Nikolaevich Syrov, Durbek Abdikhoshimovich Usmanov
  chemistry of plant raw material.2021; (1): 197.     CrossRef
• Chronically Elevated Exogenous Glucose Elicits Antipodal Effects on the Proteome Signature of Differentiating Human iPSC-Derived Pancreatic Progenitors
  Luiza Ghila, Thomas Aga Legøy, Andreas Frøslev Mathisen, Shadab Abadpour, Joao A. Paulo, Hanne Scholz, Helge Ræder, Simona Chera
  International Journal of Molecular Sciences.2021; 22(7): 3698.     CrossRef
• Effect of Type-2 Diabetes Mellitus in Retinopathy Patients on MDA, SOD Activity and its Correlation with HbA1c
  Yali Hou, Mei Lin, Xuan Qiu, Mingjuan He, Yu Zhang, Feifei Guo
  Brazilian Archives of Biology and Technology.2021;[Epub]     CrossRef
• Ameliorative effects of Hydrolea zeylanica in streptozotocin-induced oxidative stress and metabolic changes in diabetic rats
  Sandeep Kumar Swain, Umesh Chandra Dash, Satish Kanhar, Atish Kumar Sahoo
  Journal of Ethnopharmacology.2020; 247: 112257.     CrossRef
• Imbalance in the antioxidant defence system and pro-genotoxic status induced by high glucose concentrations: In vitro testing in human liver cells
  Mattia Acito, Desirée Bartolini, Maria Rachele Ceccarini, Carla Russo, Samuele Vannini, Luca Dominici, Michela Codini, Milena Villarini, Francesco Galli, Tommaso Beccari, Massimo Moretti
  Toxicology in Vitro.2020; 69: 105001.     CrossRef
• Synthesis of sulpha drug based hydroxytriazene derivatives: Anti-diabetic, antioxidant, anti-inflammatory activity and their molecular docking studies
  Poonam Sharma, Varsha Dayma, Aparna Dwivedi, Prabhat K. Baroliya, I.P. Tripathi, Murugesan Vanangamudi, R.S. Chauhan, A.K. Goswami
  Bioorganic Chemistry.2020; 96: 103642.     CrossRef
• Analysis of long non-coding RNA expression profiles in high-glucose treated vascular endothelial cells
  Erqin Xu, Xiaolei Hu, Xiaoli Li, Guoxi Jin, Langen Zhuang, Qiong Wang, Xiaoyan Pei
  BMC Endocrine Disorders.2020;[Epub]     CrossRef
• Potent α-amylase inhibitors and radical (DPPH and ABTS) scavengers based on benzofuran-2-yl(phenyl)methanone derivatives: Syntheses, in vitro, kinetics, and in silico studies
  Irfan Ali, Rafaila Rafique, Khalid Mohammed Khan, Sridevi Chigurupati, Xingyue Ji, Abdul Wadood, Ashfaq Ur Rehman, Uzma Salar, Muhammad Shahid Iqbal, Muhammad Taha, Shahnaz Perveen, Basharat Ali
  Bioorganic Chemistry.2020; 104: 104238.     CrossRef
• A review of fibroblast growth factor 21 in diabetic cardiomyopathy
  Xiang Zhang, Luo Yang, Xiongfeng Xu, Fengjuan Tang, Peng Yi, Bo Qiu, Yarong Hao
  Heart Failure Reviews.2019; 24(6): 1005.     CrossRef
• Recent advances in the pathogenesis of microvascular complications in diabetes
  Sungmi Park, Hyeon-Ji Kang, Jae-Han Jeon, Min-Ji Kim, In-Kyu Lee
  Archives of Pharmacal Research.2019; 42(3): 252.     CrossRef
• Metabolic syndrome status over 2 years predicts incident chronic kidney disease in mid-life adults: a 10-year prospective cohort study
  So Jin Lee, Hun Ju Lee, Hyun jeong Oh, Taehwa Go, Dae Ryong Kang, Jang Young Kim, Ji Hye Huh
  Scientific Reports.2018;[Epub]     CrossRef
• Role of peroxisome proliferator–activated receptor-gamma activation on visfatin, advanced glycation end products, and renal oxidative stress in obesity-induced type 2 diabetes mellitus
  A Tabassum, T Mahboob
  Human & Experimental Toxicology.2018; 37(11): 1187.     CrossRef
• Coffee consumption and reduced risk of developing type 2 diabetes: a systematic review with meta-analysis
  Mattias Carlström, Susanna C Larsson
  Nutrition Reviews.2018; 76(6): 395.     CrossRef
• Liraglutide ameliorates early renal injury by the activation of renal FoxO1 in a type 2 diabetic kidney disease rat model
  Pin Chen, Xiaozhi Shi, Xiangjin Xu, Yiyang Lin, Zhulin Shao, Rongdan Wu, Lihong Huang
  Diabetes Research and Clinical Practice.2018; 137: 173.     CrossRef
• Antioxidant effects of vitamins in type 2 diabetes: a meta-analysis of randomized controlled trials
  Maria E. Balbi, Fernanda S. Tonin, Antonio M. Mendes, Helena H. Borba, Astrid Wiens, Fernando Fernandez-Llimos, Roberto Pontarolo
  Diabetology & Metabolic Syndrome.2018;[Epub]     CrossRef
• Gilbert syndrome in patients with type 1 diabetes-Prevalence, glycemic control, and microalbuminuria
  Sigal Singer, Nurit Pilpel, Orit Pinhas-Hamiel
  Pediatric Diabetes.2017; 18(8): 803.     CrossRef
• Low serum bilirubin level predicts the development of chronic kidney disease in patients with type 2 diabetes mellitus
  Kang Hee Ahn, Sang Soo Kim, Won Jin Kim, Jong Ho Kim, Yun Jeong Nam, Su Bin Park, Yun Kyung Jeon, Bo Hyun Kim, In Joo Kim, Yong Ki Kim
  The Korean Journal of Internal Medicine.2017; 32(5): 875.     CrossRef
• Tiron ameliorates high glucose‐induced cardiac myocyte apoptosis by PKCδ‐dependent inhibition of osteopontin
  Ping Jiang, Deling Zhang, Hong Qiu, Xianqi Yi, Yemin Zhang, Yingkang Cao, Bo Zhao, Zhongyuan Xia, Changhua Wang
  Clinical and Experimental Pharmacology and Physiology.2017; 44(7): 760.     CrossRef
• Protective effects of 6-Gingerol on vascular endothelial cell injury induced by high glucose via activation of PI3K-AKT-eNOS pathway in human umbilical vein endothelial cells
  Dan Liu, Mengqing Wu, Yi Lu, Tao Xian, Yupeng Wang, Bowei Huang, Guohua Zeng, Qiren Huang
  Biomedicine & Pharmacotherapy.2017; 93: 788.     CrossRef
• Adenosine signaling in diabetes mellitus and associated cardiovascular and renal complications
  Maria Peleli, Mattias Carlstrom
  Molecular Aspects of Medicine.2017; 55: 62.     CrossRef
• Diabetes and increased lipid peroxidation are associated with systemic inflammation even in well-controlled patients
  Alliny de Souza Bastos, Dana T. Graves, Ana Paula de Melo Loureiro, Carlos Rossa Júnior, Sâmia Cruz Tfaile Corbi, Fausto Frizzera, Raquel Mantuaneli Scarel-Caminaga, Niels Olsen Câmara, Oelisoa M. Andriankaja, Meire I. Hiyane, Silvana Regina Perez Orrico
  Journal of Diabetes and its Complications.2016; 30(8): 1593.     CrossRef
• Agkistrodon acutus-purified protein C activator protects human umbilical vein endothelial cells against H2O2-induced apoptosis
  Shu Li, Yun Hong, Xin Jin, Xianwei Li, Entao Sun, Genbao Zhang, Linming Lu, Liuwang Nie
  Pharmaceutical Biology.2016; 54(12): 3285.     CrossRef
• The impact of mast cells on cardiovascular diseases
  Eva Kritikou, Johan Kuiper, Petri T. Kovanen, Ilze Bot
  European Journal of Pharmacology.2016; 778: 103.     CrossRef
• Comparison of acarbose and metformin therapy in newly diagnosed type 2 diabetic patients with overweight and/or obesity
  Weiping Sun, Chunping Zeng, Lizhen Liao, Juan Chen, Ying Wang
  Current Medical Research and Opinion.2016; 32(8): 1389.     CrossRef
• Mechanisms for the cardiovascular effects of glucagon-like peptide-1
  H. Poudyal
  Acta Physiologica.2016; 216(3): 277.     CrossRef
• Integrated scientific data bases review on asulacrine and associated toxicity
  Attia Afzal, Muhammad Sarfraz, Zimei Wu, Guangji Wang, Jianguo Sun
  Critical Reviews in Oncology/Hematology.2016; 104: 78.     CrossRef
• Impact of Diabetes and Defective Thyroid Ontogenesis on Audition
  Luciene da Cruz Fernandes
  Journal of Diabetes, Metabolic Disorders & Control.2016;[Epub]     CrossRef
• Serum Total Bilirubin Levels Provide Additive Risk Information over the Framingham Risk Score for Identifying Asymptomatic Diabetic Patients at Higher Risk for Coronary Artery Stenosis
  Jaechan Leem, Eun Hee Koh, Jung Eun Jang, Chang-Yun Woo, Jin Sun Oh, Min Jung Lee, Joon-Won Kang, Tae-Hwan Lim, Chang Hee Jung, Woo Je Lee, Joong-Yeol Park, Ki-Up Lee
  Diabetes & Metabolism Journal.2015; 39(5): 414.     CrossRef
• Clinical implications of carotid artery intima media thickness assessment on cardiovascular risk stratification in hyperlipidemic Korean adults with diabetes: the ALTO study
  Eun-Gyoung Hong, Jung Hun Ohn, Seong Jin Lee, Hyuk Sang Kwon, Sin Gon Kim, Dong Jun Kim, Dong Sun Kim
  BMC Cardiovascular Disorders.2015;[Epub]     CrossRef
• Undiagnosed diabetes is prevalent in younger adults and associated with a higher risk cardiometabolic profile compared to diagnosed diabetes
  Yong-ho Lee, Ehrin J. Armstrong, Gyuri Kim, Jaewon Oh, Seok-Min Kang, Byung-Wan Lee, Chul Woo Ahn, Bong Soo Cha, Hyun Chul Lee, Christos S. Mantzoros, Eun Seok Kang
  American Heart Journal.2015; 170(4): 760.     CrossRef
• Common Polymorphisms in Antioxidant Genes are Associated with Diabetic Nephropathy in Type 2 Diabetes Patients
  Jasna Klen, Katja Goričar, Andrej Janež, Vita Dolžan
  Personalized Medicine.2015; 12(3): 187.     CrossRef
• Increased endogenous serotonin level in diabetic conditions may lead to cardiac valvulopathy via reactive oxygen species regulation
  Tahir Ali, Hina Waheed, Farhat Shaheen, Madiha Mahmud, Qamar Javed, Iram Murtaza
  Biologia.2015; 70(2): 273.     CrossRef
• Antioxidant Effects of Statins in the Management of Cardiometabolic Disorders
  Soo Lim, Philip Barter
  Journal of Atherosclerosis and Thrombosis.2014; 21(10): 997.     CrossRef
• Evidence-Based Practice Use of Incretin-Based Therapy in the Natural History of Diabetes
  Stanley Schwartz
  Postgraduate Medicine.2014; 126(3): 66.     CrossRef
• Low serum bilirubin concentration is a novel risk factor for the development of albuminuria in patients with type 2 diabetes
  Hiroshi Okada, Michiaki Fukui, Muhei Tanaka, Shinobu Matsumoto, Kanae Kobayashi, Hiroya Iwase, Kiichiro Tomiyasu, Koji Nakano, Goji Hasegawa, Naoto Nakamura
  Metabolism.2014; 63(3): 409.     CrossRef
• Serum total bilirubin levels and prevalence of diabetic retinopathy in a Chinese population (中国人群血清总胆红素水平与糖尿病视网膜病变相关性的研究)
  Syeda Sadia Najam, Jichao Sun, Jie Zhang, Min Xu, Jieli Lu, Kan Sun, Mian Li, Tiange Wang, Yufang Bi, Guang Ning
  Journal of Diabetes.2014; 6(3): 221.     CrossRef
• Roles of oxidative stress, adiponectin, and nuclear hormone receptors in obesity-associated insulin resistance and cardiovascular risk
  Morihiro Matsuda, Iichiro Shimomura
  Hormone Molecular Biology and Clinical Investigation.2014;[Epub]     CrossRef
• Unilateral injection of Aβ25–35 in the hippocampus reduces the number of dendritic spines in hyperglycemic rats
  Zayda Lazcano, Oscar Solis, María Elena Bringas, Daniel Limón, Alfonso Diaz, Blanca Espinosa, Isabel García‐Peláez, Gonzalo Flores, Jorge Guevara
  Synapse.2014; 68(12): 585.     CrossRef
• Role of angiotensin-converting enzyme 2 (ACE2) in diabetic cardiovascular complications
  Vaibhav B. Patel, Nirmal Parajuli, Gavin Y. Oudit
  Clinical Science.2014; 126(7): 471.     CrossRef
• Pathogenesis of Chronic Hyperglycemia: From Reductive Stress to Oxidative Stress
  Liang-Jun Yan
  Journal of Diabetes Research.2014; 2014: 1.     CrossRef
• Daily intake of vitamin D‐ or calcium‐vitamin D‐fortified Persian yogurt drink (doogh) attenuates diabetes‐induced oxidative stress: evidence for antioxidative properties of vitamin D
  B. Nikooyeh, T. R. Neyestani, N. Tayebinejad, H. Alavi‐Majd, N. Shariatzadeh, A. Kalayi, M. Zahedirad, S. Heravifard, S. Salekzamani
  Journal of Human Nutrition and Dietetics.2014; 27(s2): 276.     CrossRef
• Roles of adiponectin and oxidative stress in obesity-associated metabolic and cardiovascular diseases
  Morihiro Matsuda, Iichiro Shimomura
  Reviews in Endocrine and Metabolic Disorders.2014; 15(1): 1.     CrossRef
• PKCδ-dependent Activation of the Ubiquitin Proteasome System is Responsible for High Glucose-induced Human Breast Cancer MCF-7 Cell Proliferation, Migration and Invasion
  Shan Zhu, Feng Yao, Wen-Huan Li, Jin-Nan Wan, Yi-Min Zhang, Zhao Tang, Shahzad Khan, Chang-Hua Wang, Sheng-Rong Sun
  Asian Pacific Journal of Cancer Prevention.2013; 14(10): 5687.     CrossRef
• Increased oxidative stress in obesity: Implications for metabolic syndrome, diabetes, hypertension, dyslipidemia, atherosclerosis, and cancer
  Morihiro Matsuda, Iichiro Shimomura
  Obesity Research & Clinical Practice.2013; 7(5): e330.     CrossRef
• Hydrogen Sulfide Suppresses High Glucose–Induced Expression of Intercellular Adhesion Molecule-1 in Endothelial Cells
  Qingbo Guan, Xiaolei Wang, Ling Gao, Jicui Chen, Yuantao Liu, Chunxiao Yu, Nan Zhang, Xu Zhang, Jiajun Zhao
  Journal of Cardiovascular Pharmacology.2013; 62(3): 278.     CrossRef
• Clinical Marker of Platelet Hyperreactivity in Diabetes Mellitus
  Jin Hwa Kim, Hak Yeon Bae, Sang Yong Kim
  Diabetes & Metabolism Journal.2013; 37(6): 423.     CrossRef
• Glucose initially inhibits and later stimulates blood ROS generation
  Thomas Stief
  Journal of Diabetes Mellitus.2013; 03(01): 15.     CrossRef
• Oxidative Stress in Cardiovascular Diseases and Obesity: Role of p66Shc and Protein Kinase C
  Elena De Marchi, Federica Baldassari, Angela Bononi, Mariusz R. Wieckowski, Paolo Pinton
  Oxidative Medicine and Cellular Longevity.2013; 2013: 1.     CrossRef
• Toxicological and pharmacological concerns on oxidative stress and related diseases
  Soodabeh Saeidnia, Mohammad Abdollahi
  Toxicology and Applied Pharmacology.2013; 273(3): 442.     CrossRef
• Comparison of antioxidant, α-glucosidase inhibition and anti-inflammatory activities of the leaf and root extracts ofSmilax chinaL.
  Kyoung Kon Kim, Yun Hwan Kang, Dae Jung Kim, Tae Woo Kim, Myeon Choe
  Journal of Nutrition and Health.2013; 46(4): 315.     CrossRef
• Correlation between blood glucose fluctuations and activation of oxidative stress in type 1 diabetic children during the acute metabolic disturbance period
  Di WU, Chun-xiu GONG, Xi MENG, Qiu-lan YANG
  Chinese Medical Journal.2013; 126(21): 4019.     CrossRef
• Oxidative stress and its complications in human health
  Guniz M. Koksal
  Advances in Bioscience and Biotechnology.2012; 03(08): 1113.     CrossRef

Citations

Citations to this article as recorded by  

• Cytoprotective Effect of Hot-Water Extracts of Protaetia brevitarsis seulensis Larvae in Cisplatin-Treated Macrophages
  Bo-Gyeong Yoo, Jun-Pyo Hong, Ha-Yeon Song, Eui-Hong Byun
  Journal of the Korean Society of Food Science and Nutrition.2022; 51(12): 1252.     CrossRef
• The Effects of LR3 and SP6 Acupuncture on Renal Damage in Streptozotocin-induced Diabetic Mice
  Cho In Lee, Hyun Jong Lee, Yun Kyu Lee, Seong Chul Lim, Jae Soo Kim
  The Acupuncture.2015; 32(3): 41.     CrossRef
• Effect of Chungkukjang supplementation on oxidative stress and antioxidant nutrients of diabetic rats induced by streptozotocin
  Heyun-Sook Park, Hyun-Joo Kong, Eon-Hee Lee, Eun-Mi Choi, Joung-Hyeon Jang, Myoung-Hee Lee, Ju-Yeon Hong, Su-Jung Hwang, Hyeon-A Jung, Kyung-Mi Yang
  Korean Journal of Food Preservation.2015; 22(2): 281.     CrossRef
• The Effects of Several Halophytes on Insulin Resistance in Otsuka Long-evans Tokushima Fatty Rats
  Jeong-Yong Cho, Zhangjun Huang, Sun-Young Park, Kyung-Hee Park, Tong-Kun Pai, So-Young Kim, Haeng-Ran Kim, Kyung-Sik Ham
  Korean Journal of Food Science and Technology.2014; 46(1): 100.     CrossRef
• Protective Effects of Radiation-induced Blackberry Mutant Extract on Carbon Tetrachloride (CCl4)-induced Liver Injury in Sprague-Dawley Rats
  Byoung Ok Cho, Chang-Wook Lee, Yangkang So, Chang-Hyun Jin, Hong-Sun Yook, Myung-Woo Byun, Yong-Wook Jeong, Jong Chun Park, Il-Yun Jeong
  Journal of the Korean Society of Food Science and Nutrition.2014; 43(6): 807.     CrossRef
• Antioxidant Activities and α-Glucosidase Inhibitory Effect of Water Extracts from Medicinal Plants
  Hyun Sook Kim, Tae Woo Kim, Dae Jung Kim, Jae Sung Lee, Kyoung Kon Kim, Myeon Choe
  Korean Journal of Medicinal Crop Science.2013; 21(3): 197.     CrossRef
• Antioxidant Effect of Hot water and Ethanol extracts from Cheonnyuncho (Opuntia humifusa) on Reactive Oxygen Species (ROS) Production in 3T3-L1 Adipocytes
  Bo-Ra Yoon, Young-Jun Lee, Sun-Gu Kim, Jung-Young Jang, Hyo-Ku Lee, Seong-Kap Rhee, Hee-Do Hong, Hyeon-Son Choi, Boo-Yong Lee, Ok-Hwan Lee
  Korean Journal of Food Preservation.2012; 19(3): 443.     CrossRef
• Inhibitory Effects of Panax ginseng C. A. Mayer Treated with High Temperature and High Pressure on Oxidative Stress
  Bo-Ra Yoon, Young-Jun Lee, Hee-Do Hong, Young-Chul Lee, Young-Chan Kim, Young Kyoung Rhee, Kyung-Tack Kim, Ok-Hwan Lee
  The Korean Journal of Food And Nutrition.2012; 25(4): 800.     CrossRef
• Effect of Dietary Supplementation of β-Carotene on Hepatic Antioxidant Enzyme Activities and Glutathione Concentration in Diabetic Rats
  Jung-Hyun Jang, Kyeung-Soon Lee, Jung-Sook Seo
  Journal of the Korean Society of Food Science and Nutrition.2011; 40(8): 1092.     CrossRef
• An Association between 609 C →T Polymorphism in NAD(P)H: Quinone Oxidoreductase 1 (NQO1) Gene and Blood Glucose Levels in Korean Population
  Dohee Kim
  Korean Diabetes Journal.2009; 33(1): 24.     CrossRef

Citations

Citations to this article as recorded by  

• High Glucose and/or Free Fatty Acid Damage Vascular Endothelial Cells via Stimulating of NAD(P)H Oxidase-induced Superoxide Production from Neutrophils
  Sang Soo Kim, Sun Young Kim, Soo Hyung Lee, Yang Ho Kang, In Ju Kim, Yong Ki Kim, Seok Man Son
  Korean Diabetes Journal.2009; 33(2): 94.     CrossRef