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Volume 40(1); February 2016
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Novel Molecular Mechanisms in the Development of Non-Alcoholic Steatohepatitis
Davide Povero, Ariel E. Feldstein
Diabetes Metab J. 2016;40(1):1-11.   Published online February 19, 2016
DOI: https://doi.org/10.4093/dmj.2016.40.1.1
  • 6,189 View
  • 56 Download
  • 45 Web of Science
  • 46 Crossref
AbstractAbstract PDFPubReader   

Non-alcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease in adults and children worldwide. NAFLD has become a severe health issue and it can progress towards a more severe form of the disease, the non-alcoholic steatohepatitis (NASH). A combination of environmental factors, host genetics, and gut microbiota leads to excessive accumulation of lipids in the liver (steatosis), which may result in lipotoxicity and trigger hepatocyte cell death, liver inflammation, fibrosis, and pathological angiogenesis. NASH can further progress towards liver cirrhosis and cancer. Over the last few years, cell-derived extracellular vesicles (EVs) have been identified as effective cell-to-cell messengers that transfer several bioactive molecules in target cells, modulating the pathogenesis and progression of NASH. In this review, we focused on recently highlighted aspects of molecular pathogenesis of NASH, mediated by EVs via their bioactive components. The studies included in this review summarize the state of art regarding the role of EVs during the progression of NASH and bring novel insight about the potential use of EVs for diagnosis and therapeutic strategies for patients with this disease.

Citations

Citations to this article as recorded by  
  • Walnut fruit diaphragm ethanol extract ameliorates damage due to Triton WR‐1339‐induced hyperlipidemia in rats
    Esra Palabiyik, Ayse Nurseli Sulumer, Handan Uguz, Bahri Avci, Seda Askin, Hakan Askin
    European Journal of Lipid Science and Technology.2024;[Epub]     CrossRef
  • Extracellular Vesicles and Their Correlation with Inflammatory Factors in an Experimental Model of Steatotic Liver Disease Associated with Metabolic Dysfunction
    Melina Belén Keingeski, Larisse Longo, Vitória Brum da Silva Nunes, Fabrício Figueiró, Danieli Rosane Dallemole, Adriana Raffin Pohlmann, Thalia Michele Vier Schmitz, Patrícia Luciana da Costa Lopez, Mário Reis Álvares-da-Silva, Carolina Uribe-Cruz
    Metabolic Syndrome and Related Disorders.2024; 22(5): 394.     CrossRef
  • β-sitosterol attenuates high- fat diet-induced hepatic steatosis in rats by modulating lipid metabolism, inflammation and ER stress pathway
    Omayma AR Abo-Zaid, Fatma SM Moawed, Effet Soliman Ismail, Mostafa A. Farrag
    BMC Pharmacology and Toxicology.2023;[Epub]     CrossRef
  • Phospholipid metabolism in the liver – Implications for phosphatidylserine in non-alcoholic fatty liver disease
    Marziyeh Anari, Magdalene K. Montgomery
    Biochemical Pharmacology.2023; 213: 115621.     CrossRef
  • Exosome GLUT1 derived from hepatocyte identifies the risk of non-alcoholic steatohepatitis and fibrosis
    Wenyan Zhang, Jing Zhang, Honglin Shi, Fang Liu, Haibin Yu, Hongbo Shi
    Hepatology International.2023; 17(5): 1170.     CrossRef
  • Role of extracellular vesicles in nonalcoholic fatty liver disease
    Wei Jiang, Youhui Xu, Jou-Chen Chen, Yi-Hung Lee, Yushin Hu, Chang-Hai Liu, Enqiang Chen, Hong Tang, Hua Zhang, Dongbo Wu
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Angiopoietin-2 levels correlates with disease activity in children with nonalcoholic fatty liver disease
    Melania Manco, Nadia Panera, Annalisa Crudele, Maria Rita Braghini, Marzia Bianchi, Donatella Comparcola, Rita De Vito, Giuseppe Maggiore, Anna Alisi
    Pediatric Research.2022; 91(7): 1781.     CrossRef
  • The Neglected Role of Bile Duct Epithelial Cells in NASH
    Massimiliano Cadamuro, Alberto Lasagni, Samantha Sarcognato, Maria Guido, Roberto Fabris, Mario Strazzabosco, Alastair J. Strain, Paolo Simioni, Erica Villa, Luca Fabris
    Seminars in Liver Disease.2022; 42(01): 034.     CrossRef
  • Relationship between prevalence and risk of osteoporosis or osteoporotic fracture with non-alcoholic fatty liver disease: A systematic review and meta-analysis
    Binjing Pan, Jing Cai, Pingping Zhao, Jingfang Liu, Songbo Fu, Gaojing Jing, Qianglong Niu, Qiong Li
    Osteoporosis International.2022; 33(11): 2275.     CrossRef
  • Ethanol Extract of Pinus koraiensis Leaves Mitigates High Fructose-Induced Hepatic Triglyceride Accumulation and Hypertriglyceridemia
    Min-Ho Lee, Sunyeong Park, Yinzhu Xu, Jung-Eun Kim, Hengmin Han, Jae-Hyeon Lee, Jean Kyung Paik, Hyo-Jeong Lee
    Applied Sciences.2022; 12(13): 6745.     CrossRef
  • TWIST2 and the PPAR signaling pathway are important in the progression of nonalcoholic steatohepatitis
    Yanmei Zhang, Xiaoxiao Ge, Yongqing Li, Bingyang Zhang, Peijun Wang, Mingju Hao, Peng Gao, Yueyi Zhao, Tao Sun, Sumei Lu, Wanshan Ma
    Lipids in Health and Disease.2021;[Epub]     CrossRef
  • Allopurinol ameliorates high fructose diet induced hepatic steatosis in diabetic rats through modulation of lipid metabolism, inflammation, and ER stress pathway
    In-Jin Cho, Da-Hee Oh, Jin Yoo, You-Cheol Hwang, Kyu Jeung Ahn, Ho-Yeon Chung, Soung Won Jeong, Ju-Young Moon, Sang-Ho Lee, Sung-Jig Lim, In-Kyung Jeong
    Scientific Reports.2021;[Epub]     CrossRef
  • Tabebuia rosea (Bertol.) DC. ethanol extract attenuates body weight gain by activation of molecular mediators associated with browning
    Elsa Cecilia Pagaza-Straffon, Carla Elena Mezo-González, David Armando Chavaro-Pérez, Jorge Cornejo-Garrido, Laurence A. Marchat, Claudia G. Benítez-Cardoza, Maricruz Anaya-Reyes, Cynthia Ordaz-Pichardo
    Journal of Functional Foods.2021; 86: 104740.     CrossRef
  • Effects of Oral Vitamin C Supplementation on Liver Health and Associated Parameters in Patients With Non-Alcoholic Fatty Liver Disease: A Randomized Clinical Trial
    Zhangya He, Xiaomin Li, Hexiang Yang, Pei Wu, Shanshan Wang, Dan Cao, Xiaoxiao Guo, Zhangrui Xu, Jiayi Gao, Wanyu Zhang, Xiaoqin Luo
    Frontiers in Nutrition.2021;[Epub]     CrossRef
  • Hepatic lipid droplet homeostasis and fatty liver disease
    Fabian Seebacher, Anja Zeigerer, Nora Kory, Natalie Krahmer
    Seminars in Cell & Developmental Biology.2020; 108: 72.     CrossRef
  • Orotic acid-treated hepatocellular carcinoma cells resist steatosis by modification of fatty acid metabolism
    Johanna Matilainen, Anne-Mari Mustonen, Kirsi Rilla, Reijo Käkelä, Sanna P. Sihvo, Petteri Nieminen
    Lipids in Health and Disease.2020;[Epub]     CrossRef
  • Liver fibrogenesis: un update on established and emerging basic concepts
    Erica Novo, Claudia Bocca, Beatrice Foglia, Francesca Protopapa, Marina Maggiora, Maurizio Parola, Stefania Cannito
    Archives of Biochemistry and Biophysics.2020; 689: 108445.     CrossRef
  • Relative contribution of fat diet and physical inactivity to the development of metabolic syndrome and non-alcoholic fat liver disease in Wistar rats
    Antonio Bovolini, Juliana Garcia, Maria Amparo Andrade, José Alberto Duarte
    Physiology & Behavior.2020; 225: 113040.     CrossRef
  • Novel hepatoprotective role of Leonurine hydrochloride against experimental non-alcoholic steatohepatitis mediated via AMPK/SREBP1 signaling pathway
    Li Zhang, Hui-Xia Li, Wu-Si Pan, Farhan Ullah Khan, Cheng Qian, Feng-Rong Qi-Li, Xiaojun Xu
    Biomedicine & Pharmacotherapy.2019; 110: 571.     CrossRef
  • Association Between Nonalcoholic Fatty Liver Disease and Future Deterioration of Metabolic Health: A Cohort Study
    You‐Cheol Hwang, Hong‐Yup Ahn, Cheol‐Young Park
    Obesity.2019; 27(8): 1360.     CrossRef
  • Tumorigenesis, diagnosis, and therapeutic potential of exosomes in liver cancer
    Hongbo Wang, Zaiming Lu, Xiangxuan Zhao
    Journal of Hematology & Oncology.2019;[Epub]     CrossRef
  • Elastography in the Diagnosis of Non-Alcoholic Fatty Liver Disease
    Elena N. Shirokova, Chavdar S. Pavlov, Anna D. Karaseva, Aliya M. Alieva, Alla V. Sedova, Vladimir T. Ivashkin
    Annals of the Russian academy of medical sciences.2019; 74(1): 5.     CrossRef
  • Curcumin Recovers Intracellular Lipid Droplet Formation Through Increasing Perilipin 5 Gene Expression in Activated Hepatic Stellate Cells In Vitro
    Xiao-qun Han, San-qing Xu, Jian-guo Lin
    Current Medical Science.2019; 39(5): 766.     CrossRef
  • Lipid mediators of liver injury in nonalcoholic fatty liver disease
    Suthat Liangpunsakul, Naga Chalasani
    American Journal of Physiology-Gastrointestinal and Liver Physiology.2019; 316(1): G75.     CrossRef
  • Liver fibrosis: Pathophysiology, pathogenetic targets and clinical issues
    Maurizio Parola, Massimo Pinzani
    Molecular Aspects of Medicine.2019; 65: 37.     CrossRef
  • Ostreolysin induces browning of adipocytes and ameliorates hepatic steatosis
    Lili Nimri, Katerina Staikin, Irena Peri, Einav Yehuda‐Shnaidman, Betty Schwartz
    Journal of Gastroenterology and Hepatology.2018; 33(12): 1990.     CrossRef
  • miRNAs in patients with non-alcoholic fatty liver disease: A systematic review and meta-analysis
    Chang-Hai Liu, Javier Ampuero, Antonio Gil-Gómez, Rocío Montero-Vallejo, Ángela Rojas, Rocío Muñoz-Hernández, Rocío Gallego-Durán, Manuel Romero-Gómez
    Journal of Hepatology.2018; 69(6): 1335.     CrossRef
  • Efficient scalable production of therapeutic microvesicles derived from human mesenchymal stem cells
    Jae Min Cha, Eun Kyoung Shin, Ji Hee Sung, Gyeong Joon Moon, Eun Hee Kim, Yeon Hee Cho, Hyung Dal Park, Hojae Bae, Jinseok Kim, Oh Young Bang
    Scientific Reports.2018;[Epub]     CrossRef
  • Changes in the Structure of the Liver during Obesity (Literature Review)
    V. I. Prymachenko
    Ukraïnsʹkij žurnal medicini, bìologìï ta sportu.2018; 4(2): 45.     CrossRef
  • Recent Insights into the Pathogenesis of Nonalcoholic Fatty Liver Disease
    Juan Pablo Arab, Marco Arrese, Michael Trauner
    Annual Review of Pathology: Mechanisms of Disease.2018; 13(1): 321.     CrossRef
  • Apoptosis and non-alcoholic fatty liver diseases
    Tatsuo Kanda, Shunichi Matsuoka, Motomi Yamazaki, Toshikatsu Shibata, Kazushige Nirei, Hiroshi Takahashi, Tomohiro Kaneko, Mariko Fujisawa, Teruhisa Higuchi, Hitomi Nakamura, Naoki Matsumoto, Hiroaki Yamagami, Masahiro Ogawa, Hiroo Imazu, Kazumichi Kuroda
    World Journal of Gastroenterology.2018; 24(25): 2661.     CrossRef
  • Immunotherapy with oral administration of humanized anti-CD3 monoclonal antibody: a novel gut-immune system-based therapy for metaflammation and NASH
    Y Ilan, K Shailubhai, A Sanyal
    Clinical and Experimental Immunology.2018; 193(3): 275.     CrossRef
  • Long-term exposure to high-sucrose diet down-regulates hepatic endoplasmic reticulum-stress adaptive pathways and potentiates de novo lipogenesis in weaned male mice
    Karla Frida Torres Flister, Bruno Araújo Serra Pinto, Lucas Martins França, Caio Fernando Ferreira Coêlho, Pâmela Costa dos Santos, Caroline Castro Vale, Daniela Kajihara, Victor Debbas, Francisco Rafael Martins Laurindo, Antonio Marcus de Andrade Paes
    The Journal of Nutritional Biochemistry.2018; 62: 155.     CrossRef
  • Blood-Based Novel Biomarkers for Nonalcoholic Steatohepatitis
    Yun Qiu, Sufan Wang, Ting Wan, Mingtong Ye, Rui Jiang, Lei Pei, Lili Yang
    Biomarkers in Medicine.2018; 12(5): 501.     CrossRef
  • The effect of cannabinoid receptor 1 blockade on hepatic free fatty acid profile in mice with nonalcoholic fatty liver disease
    Bojan Jorgačević, Danijela Vučević, Ivana Đuričić, Slađana Šobajić, Dušan Mladenović, Milena Vesković, Rada Ješić Vukićević, Tatjana Radosavljević
    Chemistry and Physics of Lipids.2017; 204: 85.     CrossRef
  • Ezetimibe ameliorates steatohepatitis via AMP activated protein kinase-TFEB-mediated activation of autophagy and NLRP3 inflammasome inhibition
    Soo Hyun Kim, Gyuri Kim, Dai Hoon Han, Milim Lee, Irene Kim, Bohkyung Kim, Kook Hwan Kim, Young-Mi Song, Jeong Eun Yoo, Hye Jin Wang, Soo Han Bae, Yong-Ho Lee, Byung-Wan Lee, Eun Seok Kang, Bong-Soo Cha, Myung-Shik Lee
    Autophagy.2017; 13(10): 1767.     CrossRef
  • Obesity is more closely related with hepatic steatosis and fibrosis measured by transient elastography than metabolic health status
    Ji Hye Huh, Kwang Joon Kim, Seung Up Kim, Seung Hwan Han, Kwang-Hyub Han, Bong-Soo Cha, Choon Hee Chung, Byung-Wan Lee
    Metabolism.2017; 66: 23.     CrossRef
  • Significant liver fibrosis assessed using liver transient elastography is independently associated with low bone mineral density in patients with non-alcoholic fatty liver disease
    Gyuri Kim, Kwang Joon Kim, Yumie Rhee, Sung-Kil Lim, Salvatore Petta
    PLOS ONE.2017; 12(7): e0182202.     CrossRef
  • Increased risk for development of coronary artery calcification in subjects with non-alcoholic fatty liver disease and systemic inflammation
    Jihyun Kim, Da Young Lee, Se Eun Park, Cheol-Young Park, Won-Young Lee, Ki-Won Oh, Sung-Woo Park, Eun-Jung Rhee, Susanne Kaser
    PLOS ONE.2017; 12(7): e0180118.     CrossRef
  • Ameliorative effects of Compound K and ginsenoside Rh1 on non-alcoholic fatty liver disease in rats
    Xu-Jia Chen, Wen-Jing Liu, Meng-Liang Wen, Hong Liang, Shao-Mei Wu, Yun-Zhen Zhu, Jiang-Yuan Zhao, Xiang-Qian Dong, Ming-Gang Li, Li Bian, Cheng-Gang Zou, Lan-Qing Ma
    Scientific Reports.2017;[Epub]     CrossRef
  • Loss of miR-141/200c ameliorates hepatic steatosis and inflammation by reprogramming multiple signaling pathways in NASH
    Melanie Tran, Sang-Min Lee, Dong-Ju Shin, Li Wang
    JCI Insight.2017;[Epub]     CrossRef
  • Galectin-3 and IL-33/ST2 axis roles and interplay in diet-induced steatohepatitis
    Nada Pejnovic, Ilija Jeftic, Nemanja Jovicic, Nebojsa Arsenijevic, Miodrag L Lukic
    World Journal of Gastroenterology.2016; 22(44): 9706.     CrossRef
  • Hepatocyte mitochondrial DNA released in microparticles and toll‐like receptor 9 activation: A link between lipotoxicity and inflammation during nonalcoholic steatohepatitis
    Maria Eugenia Inzaugarat, Alexander Wree, Ariel E. Feldstein
    Hepatology.2016; 64(2): 669.     CrossRef
  • Metabolic aspects of adult patients with nonalcoholic fatty liver disease
    Ludovico Abenavoli, Natasa Milic, Laura Di Renzo, Tomislav Preveden, Milica Medić-Stojanoska, Antonino De Lorenzo
    World Journal of Gastroenterology.2016; 22(31): 7006.     CrossRef
  • Pediatric non-alcoholic fatty liver disease: Recent solutions, unresolved issues, and future research directions
    Maria Grazia Clemente, Claudia Mandato, Marco Poeta, Pietro Vajro
    World Journal of Gastroenterology.2016; 22(36): 8078.     CrossRef
  • Gut Microbiota and Metabolic Health: The Potential Beneficial Effects of a Medium Chain Triglyceride Diet in Obese Individuals
    Sabri Rial, Antony Karelis, Karl-F. Bergeron, Catherine Mounier
    Nutrients.2016; 8(5): 281.     CrossRef
Obesity and Metabolic Syndrome
Brown Fat and Browning for the Treatment of Obesity and Related Metabolic Disorders
So Hun Kim, Jorge Plutzky
Diabetes Metab J. 2016;40(1):12-21.   Published online January 21, 2016
DOI: https://doi.org/10.4093/dmj.2016.40.1.12
  • 8,189 View
  • 117 Download
  • 159 Web of Science
  • 162 Crossref
AbstractAbstract PDFPubReader   

Brown fat is a specialized fat depot that can increase energy expenditure and produce heat. After the recent discovery of the presence of active brown fat in human adults and novel transcription factors controlling brown adipocyte differentiation, the field of the study of brown fat has gained great interest and is rapidly growing. Brown fat expansion and/or activation results in increased energy expenditure and a negative energy balance in mice and limits weight gain. Brown fat is also able to utilize blood glucose and lipid and results in improved glucose metabolism and blood lipid independent of weight loss. Prolonged cold exposure and beta adrenergic agonists can induce browning of white adipose tissue. The inducible brown adipocyte, beige adipocyte evolving by thermogenic activation of white adipose tissue have different origin and molecular signature from classical brown adipocytes but share the characteristics of high mitochondria content, UCP1 expression and thermogenic capacity when activated. Increasing browning may also be an efficient way to increase whole brown fat activity. Recent human studies have shown possibilities that findings in mice can be reproduced in human, making brown fat a good candidate organ to treat obesity and its related disorders.

Citations

Citations to this article as recorded by  
  • Modulation of angiogenic switch in reprogramming browning and lipid metabolism in white adipocytes
    Sreelekshmi Sreekumar, Karyath Palliyath Gangaraj, Manikantan Syamala Kiran
    Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids.2024; 1869(1): 159423.     CrossRef
  • Anti-Obesity Effects of GABA in C57BL/6J Mice with High-Fat Diet-Induced Obesity and 3T3-L1 Adipocytes
    Heegu Jin, Hyein Han, Gunju Song, Hyun-Ji Oh, Boo-Yong Lee
    International Journal of Molecular Sciences.2024; 25(2): 995.     CrossRef
  • Citrus aurantium L. and synephrine improve brown adipose tissue function in adolescent mice programmed by early postnatal overfeeding
    Andressa Cardoso Guimarães, Egberto Gaspar de Moura, Stephanie Giannini Silva, Bruna Pereira Lopes, Iala Milene Bertasso, Carla Bruna Pietrobon, Fernanda Torres Quitete, Tayanne de Oliveira Malafaia, Érica Patrícia Garcia Souza, Patrícia Cristina Lisboa,
    Frontiers in Nutrition.2024;[Epub]     CrossRef
  • Au@16-pH-16/miR-21 mimic nanosystem: An efficient treatment for obesity through browning and thermogenesis induction
    Said Lhamyani, Adriana-Mariel Gentile, María Mengual-Mesa, Elia Grueso, Rosa M. Giráldez-Pérez, José Carlos Fernandez-Garcia, Antonio Vega-Rioja, Mercedes Clemente-Postigo, John R. Pearson, Isabel González-Mariscal, Gabriel Olveira, Francisco-Javier Bermu
    Biomedicine & Pharmacotherapy.2024; 171: 116104.     CrossRef
  • Walnut supplementation increases levels of UCP1 and CD36 in brown adipose tissue independently of diet type
    Tamara Dakic, Dusan Jeremic, Iva Lakic, Nebojsa Jasnic, Aleksandra Ruzicic, Predrag Vujovic, Tanja Jevdjovic
    Molecular and Cellular Biochemistry.2024;[Epub]     CrossRef
  • Role of micro‐RNAs associated with adipose‐derived extracellular vesicles in metabolic disorders
    Thomas Payet, Elisa Gabinaud, Jean‐François Landrier, Lourdes Mounien
    Obesity Reviews.2024;[Epub]     CrossRef
  • Spexin ameliorated obesity-related metabolic disorders through promoting white adipose browning mediated by JAK2-STAT3 pathway
    Bihe Zeng, Qin Shen, Bo Wang, Xuan Tang, Jiaqi Jiang, Yiming Zheng, Hongbiao Huang, Wenyu Zhuo, Wang Wang, Yang Gao, Xuan Li, Shuhui Wang, Wenjie Li, Guanghui Qian, Jie Qin, Miao Hou, Haitao Lv
    Nutrition & Metabolism.2024;[Epub]     CrossRef
  • Genipin improves obesity through promoting bile secretion and changing bile acids composition in diet-induced obese rats
    Lili Guan, Lei Zhang, Dezheng Gong, Pengcheng Li, Shengnan Zhu, Jiulan Tang, Man Du, Maokun Zhang, Yuan Zou
    Journal of Pharmacy and Pharmacology.2024; 76(7): 897.     CrossRef
  • Development of Recombinant High-Density Lipoprotein Platform with Innate Adipose Tissue-Targeting Abilities for Regional Fat Reduction
    Junhua Han, Yingxian Chen, Xiaolong Xu, Qingmeng Li, Xin Xiang, Jianzhong Shen, Xiaowei Ma
    ACS Nano.2024; 18(21): 13635.     CrossRef
  • Neuronostatin regulates proliferation and differentiation of rat brown primary preadipocytes
    Małgorzata Krążek, Tatiana Wojciechowicz, Joanna Fiedorowicz, Mathias Z. Strowski, Krzysztof W. Nowak, Marek Skrzypski
    FEBS Letters.2024;[Epub]     CrossRef
  • UV Irradiation Increases Appetite and Prevents Body Weight Gain through the Upregulation of Norepinephrine in Mice
    Qing-Ling Quan, Eun Ju Kim, Sungsoo Kim, Yeon Kyung Kim, Min Hwa Chung, Yu-Dan Tian, Chang-Yup Shin, Dong Hun Lee, Jin Ho Chung
    Journal of Investigative Dermatology.2024;[Epub]     CrossRef
  • A Newly Synbiotic Combination Alleviates Obesity by Modulating the Gut Microbiota–Fat Axis and Inhibiting the Hepatic TLR4/NF‐κB Signaling Pathway
    Yongbo Kang, Peng Ren, Xiaorong Shen, Xiaoyu Kuang, Xiaodan Yang, Haixia Liu, Huan Yan, Hao Yang, Xing Kang, Zeyuan Ding, Xuguang Luo, Jieqiong Ma, Ying Yang, Weiping Fan
    Molecular Nutrition & Food Research.2023;[Epub]     CrossRef
  • Lacticaseibacillus paracasei AO356 ameliorates obesity by regulating adipogenesis and thermogenesis in C57BL/6J male mice
    Young In Kim, Eun-Sook Lee, Eun-Ji Song, Dong-Uk Shin, Ji-Eun Eom, Hee Soon Shin, Jung Eun Kim, Ju Yeoun Oh, Young-Do Nam, So-Young Lee
    Journal of Functional Foods.2023; 101: 105404.     CrossRef
  • Effects of caffeoylquinic acid analogs derived from aerial parts of Artemisia iwayomogi on adipogenesis
    Su-Young Han, Jisu Kim, Bo Kyeong Kim, Wan Kyunn Whang, Hyeyoung Min
    Food Science and Biotechnology.2023; 32(9): 1215.     CrossRef
  • Anti-obesity effects of Lactiplantibacillus plantarum SKO-001 in high-fat diet-induced obese mice
    Mi Jin Choi, Hana Yu, Jea Il Kim, Hee Seo, Ju Gyeong Kim, Seul-Ki Kim, Hak Sung Lee, Hyae Gyeong Cheon
    European Journal of Nutrition.2023; 62(4): 1611.     CrossRef
  • Meteorin-like Protein and Asprosin Levels in Children and Adolescents with Obesity and Their Relationship with Insulin Resistance and Metabolic Syndrome
    Nariman Moradi, Reza Fadaei, Maryam Roozbehkia, Mitra Nourbakhsh, Mona Nourbakhsh, Maryam Razzaghy-Azar, Bagher Larijani
    Laboratory Medicine.2023; 54(5): 457.     CrossRef
  • A Novel Mix of Polyphenols and Micronutrients Reduces Adipogenesis and Promotes White Adipose Tissue Browning via UCP1 Expression and AMPK Activation
    Francesca Pacifici, Gina Malatesta, Caterina Mammi, Donatella Pastore, Vincenzo Marzolla, Camillo Ricordi, Francesca Chiereghin, Marco Infante, Giulia Donadel, Francesco Curcio, Annalisa Noce, Valentina Rovella, Davide Lauro, Manfredi Tesauro, Nicola Di D
    Cells.2023; 12(5): 714.     CrossRef
  • Thromboxane A2-TP axis promotes adipose tissue macrophages M1 polarization leading to insulin resistance in obesity
    Ruijie Xu, Yufeng Dai, Xu Zheng, Yongheng Yan, Zhao He, Hao Zhang, Haitao Li, Wei Chen
    Biochemical Pharmacology.2023; 210: 115465.     CrossRef
  • Green Tea Epigallocatechin Gallate Inhibits Preadipocyte Growth via the microRNA‐let‐7a/HMGA2 Signaling Pathway
    Wen‐Ting Chen, Meei‐Ju Yang, Yi‐Wei Tsuei, Tsung‐Chen Su, An‐Ci Siao, Yow‐Chii Kuo, Ling‐Ru Huang, Yi Chen, Sy‐Jou Chen, Po‐Chuan Chen, Ching‐Feng Cheng, Hui‐Chen Ku, Yung‐Hsi Kao
    Molecular Nutrition & Food Research.2023;[Epub]     CrossRef
  • Current Role and Potential of Polymeric Biomaterials in Clinical Obesity Treatment
    Rui-Chian Tang, I-Hsuan Yang, Feng-Huei Lin
    Biomacromolecules.2023; 24(8): 3438.     CrossRef
  • Short-duration cold exposure decreases fasting-induced glucose intolerance but has no effect on resting energy expenditure
    Rima Solianik, Katerina Židonienė, Marius Brazaitis
    Cryobiology.2023; 113: 104564.     CrossRef
  • Caffeine promotes the production of Irisin in muscles and thus facilitates the browning of white adipose tissue
    Chang Liu, Yi Li, Ge Song, Xuehan Li, Songyue Chen, Dixin Zou, Huixin Li, Chengyi Hu, Haotian Zhao, Yi Yan
    Journal of Functional Foods.2023; 108: 105702.     CrossRef
  • Thermogenic Modulation of Adipose Depots: A Perspective on Possible Therapeutic Intervention with Early Cardiorenal Complications of Metabolic Impairment
    Ahmed F. El-Yazbi, Mohamed A. Elrewiny, Hosam M. Habib, Ali H. Eid, Perihan A. Elzahhar, Ahmed S.F. Belal
    Molecular Pharmacology.2023; 104(5): 187.     CrossRef
  • Rabbit Meat Extract Induces Browning in 3T3−L1 Adipocytes via the AMP−Activated Protein Kinase Pathway
    In-Seon Bae, Jeong Ah Lee, Soo-Hyun Cho, Hyoun-Wook Kim, Yunseok Kim, Kangmin Seo, Hyun-Woo Cho, Min Young Lee, Ju Lan Chun, Ki Hyun Kim
    Foods.2023; 12(19): 3671.     CrossRef
  • Metabolic-Dysfunction-Associated Steatotic Liver Disease—Its Pathophysiology, Association with Atherosclerosis and Cardiovascular Disease, and Treatments
    Hidekatsu Yanai, Hiroki Adachi, Mariko Hakoshima, Sakura Iida, Hisayuki Katsuyama
    International Journal of Molecular Sciences.2023; 24(20): 15473.     CrossRef
  • Brown Fat and Nutrition: Implications for Nutritional Interventions
    Lloyd Noriega, Cheng-Ying Yang, Chih-Hao Wang
    Nutrients.2023; 15(18): 4072.     CrossRef
  • Metabolic Syndrome: A Narrative Review from the Oxidative Stress to the Management of Related Diseases
    Giovanni Martemucci, Giuseppe Fracchiolla, Marilena Muraglia, Roberta Tardugno, Roberta Savina Dibenedetto, Angela Gabriella D’Alessandro
    Antioxidants.2023; 12(12): 2091.     CrossRef
  • Metabolic responses of light and taste receptors – unexpected actions of GPCRs in adipocytes
    Onyinye Nuella Ekechukwu, Mark Christian
    Reviews in Endocrine and Metabolic Disorders.2022; 23(1): 111.     CrossRef
  • The ATF3 inducer protects against diet-induced obesity via suppressing adipocyte adipogenesis and promoting lipolysis and browning
    Hui-Chen Ku, Tsai-Yun Chan, Jia-Fang Chung, Yung-Hsi Kao, Ching-Feng Cheng
    Biomedicine & Pharmacotherapy.2022; 145: 112440.     CrossRef
  • Prednisone stimulates white adipocyte browning via β3-AR/p38 MAPK/ERK signaling pathway
    Sulagna Mukherjee, Jong Won Yun
    Life Sciences.2022; 288: 120204.     CrossRef
  • Tangeretin prevents obesity by modulating systemic inflammation, fat browning, and gut microbiota in high-fat diet-induced obese C57BL/6 mice
    Qiyang Chen, Dan Wang, Yue Gu, Zixiao Jiang, Zhiqin Zhou
    The Journal of Nutritional Biochemistry.2022; 101: 108943.     CrossRef
  • Evaluation of thermal sensitivity is of potential clinical utility for the predictive, preventive, and personalized approach advancing metabolic syndrome management
    Sujeong Mun, Kihyun Park, Siwoo Lee
    EPMA Journal.2022; 13(1): 125.     CrossRef
  • Effects of a Novel Selective Peroxisome Proliferator-Activated Receptor α Modulator, Pemafibrate, on Metabolic Parameters: A Retrospective Longitudinal Study
    Hidekatsu Yanai, Hisayuki Katsuyama, Mariko Hakoshima
    Biomedicines.2022; 10(2): 401.     CrossRef
  • Historical and cultural aspects of obesity: From a symbol of wealth and prosperity to the epidemic of the 21st century
    Marta Sumińska, Rafał Podgórski, Klaudia Bogusz‐Górna, Bogda Skowrońska, Artur Mazur, Marta Fichna
    Obesity Reviews.2022;[Epub]     CrossRef
  • Molecular Biological and Clinical Understanding of the Statin Residual Cardiovascular Disease Risk and Peroxisome Proliferator-Activated Receptor Alpha Agonists and Ezetimibe for Its Treatment
    Hidekatsu Yanai, Hiroki Adachi, Mariko Hakoshima, Hisayuki Katsuyama
    International Journal of Molecular Sciences.2022; 23(7): 3418.     CrossRef
  • Pep19 Has a Positive Effect on Insulin Sensitivity and Ameliorates Both Hepatic and Adipose Tissue Phenotype of Diet-Induced Obese Mice
    Renata Silvério, Robson Barth, Andrea S. Heimann, Patrícia Reckziegel, Gustavo J. dos Santos, Silvana Y. Romero-Zerbo, Francisco J. Bermúdez-Silva, Alex Rafacho, Emer S. Ferro
    International Journal of Molecular Sciences.2022; 23(8): 4082.     CrossRef
  • Thermogenic T cells: a cell therapy for obesity?
    Ulf H. Beier, Daniel J. Baker, Joseph A. Baur
    American Journal of Physiology-Cell Physiology.2022; 322(6): C1085.     CrossRef
  • Accumulation of γδ T cells in visceral fat with aging promotes chronic inflammation
    Maria E. C. Bruno, Sujata Mukherjee, Whitney L. Powell, Stephanie F. Mori, Franklyn K. Wallace, Beverly K. Balasuriya, Leon C. Su, Arnold J. Stromberg, Donald A. Cohen, Marlene E. Starr
    GeroScience.2022; 44(3): 1761.     CrossRef
  • Deletion of GPR30 Drives the Activation of Mitochondrial Uncoupling Respiration to Induce Adipose Thermogenesis in Female Mice
    Jing Luo, Yao Wang, Elizabeth Gilbert, Dongmin Liu
    Frontiers in Endocrinology.2022;[Epub]     CrossRef
  • Inhibition of STAT3 enhances UCP1 expression and mitochondrial function in brown adipocytes
    Lini Song, Xi Cao, Wenyi Ji, Lili Zhao, Weili Yang, Ming Lu, Jinkui Yang
    European Journal of Pharmacology.2022; 926: 175040.     CrossRef
  • TRPC5 deletion in the central amygdala antagonizes high-fat diet-induced obesity by increasing sympathetic innervation
    Huan Ma, Chengkang He, Li Li, Peng Gao, Zongshi Lu, Yingru Hu, Lijuan Wang, Yu Zhao, Tingbing Cao, Yuanting Cui, Hongting Zheng, Gangyi Yang, Zhencheng Yan, Daoyan Liu, Zhiming Zhu
    International Journal of Obesity.2022; 46(8): 1544.     CrossRef
  • Adapalene induces adipose browning through the RARβ-p38 MAPK-ATF2 pathway
    Na Hyun Lee, Mi Jin Choi, Hana Yu, Jea Il Kim, Hyae Gyeong Cheon
    Archives of Pharmacal Research.2022; 45(5): 340.     CrossRef
  • Engineering Functional Vascularized Beige Adipose Tissue from Microvascular Fragments of Models of Healthy and Type II Diabetes Conditions
    Francisca M. Acosta, Katerina Stojkova, Jingruo Zhang, Eric Ivan Garcia Huitron, Jean X. Jiang, Christopher R. Rathbone, Eric M. Brey
    Journal of Tissue Engineering.2022; 13: 204173142211093.     CrossRef
  • Atractylenolide III from Atractylodes macrocephala Koidz promotes the activation of brown and white adipose tissue through SIRT1/PGC-1α signaling pathway
    Xin Liu, Yuan Huang, Xu Liang, Qiong Wu, Nan Wang, Li-jun Zhou, Wen-wu Liu, Qun Ma, Bei Hu, Huan Gao, Ya-ling Cui, Xiang Li, Qing-chun Zhao
    Phytomedicine.2022; 104: 154289.     CrossRef
  • The pathobiology of perivascular adipose tissue (PVAT), the fourth layer of the blood vessel wall
    Cassie Hillock-Watling, Avrum I. Gotlieb
    Cardiovascular Pathology.2022; 61: 107459.     CrossRef
  • RNA-Binding Proteins in the Regulation of Adipogenesis and Adipose Function
    Pengpeng Zhang, Wenyan Wu, Chaofeng Ma, Chunyu Du, Yueru Huang, Haixia Xu, Cencen Li, Xiaofang Cheng, Ruijie Hao, Yongjie Xu
    Cells.2022; 11(15): 2357.     CrossRef
  • The Effect of Swimming Training with Cinnamon Consumption on β3-AR and ERK2 Gene Expression in the Visceral Adipose Tissue of Diabetic Rats
    Kianoosh Mohammadi, Ali Khajehlandi, Amin Mohammadi
    Gene, Cell and Tissue.2022;[Epub]     CrossRef
  • Of mice and men: Considerations on adipose tissue physiology in animal models of obesity and human studies
    Ioannis G. Lempesis, Dimitrios Tsilingiris, Junli Liu, Maria Dalamaga
    Metabolism Open.2022; 15: 100208.     CrossRef
  • The comparison of the effect of acute moderate and high-intensity exercise on the uncoupling protein -1 secretion
    Desiana Merawati, Sugiharto Sugiharto, Adi Pranoto, Olivia Andiana, Prayogi Dwina Angga
    Jurnal SPORTIF : Jurnal Penelitian Pembelajaran.2022; 8(2): 201.     CrossRef
  • Omega-3 Polyunsaturated Fatty Acids Protect against High-Fat Diet-Induced Morphological and Functional Impairments of Brown Fat in Transgenic Fat-1 Mice
    Lei Hao, Yong-Hui Nie, Chih-Yu Chen, Xiang-Yong Li, Kanakaraju Kaliannan, Jing X. Kang
    International Journal of Molecular Sciences.2022; 23(19): 11903.     CrossRef
  • Modulation of hypothalamic AMPK phosphorylation by olanzapine controls energy balance and body weight
    Vitor Ferreira, Cintia Folgueira, Maria Guillén, Pablo Zubiaur, Marcos Navares, Assel Sarsenbayeva, Pilar López-Larrubia, Jan W. Eriksson, Maria J. Pereira, Francisco Abad-Santos, Guadalupe Sabio, Patricia Rada, Ángela M. Valverde
    Metabolism.2022; 137: 155335.     CrossRef
  • Okra (Abelmoschus esculentus L. Moench) prevents obesity by reducing lipid accumulation and increasing white adipose browning in high-fat diet-fed mice
    Heegu Jin, Hyun-Ji Oh, Sehaeng Cho, Ok-Hwan Lee, Boo-Yong Lee
    Food & Function.2022; 13(22): 11840.     CrossRef
  • Functional Attenuation of UCP1 as the Potential Mechanism for a Thickened Blubber Layer in Cetaceans
    Ming Zhou, Tianzhen Wu, Yue Chen, Shixia Xu, Guang Yang, Anne Yoder
    Molecular Biology and Evolution.2022;[Epub]     CrossRef
  • Brown adipose tissue transplantation as a novel alternative to obesity treatment: a systematic review
    Moloud Payab, Mina Abedi, Najmeh Foroughi Heravani, Mahdieh Hadavandkhani, Maryam Arabi, Akram Tayanloo-Beik, Motahareh Sheikh Hosseini, Hadis Gerami, Fateme Khatami, Bagher Larijani, Mohammad Abdollahi, Babak Arjmand
    International Journal of Obesity.2021; 45(1): 109.     CrossRef
  • Corylin reduces obesity and insulin resistance and promotes adipose tissue browning through SIRT-1 and β3-AR activation
    Chin-Chuan Chen, Chen-Hsin Kuo, Yann-Lii Leu, Shu-Huei Wang
    Pharmacological Research.2021; 164: 105291.     CrossRef
  • Inducible beige adipocytes improve impaired glucose metabolism in interscapular BAT-removal mice
    Xiao-Wei Jia, Dong-Liang Fang, Xin-Yi Shi, Tao Lu, Chun Yang, Yan Gao
    Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids.2021; 1866(3): 158871.     CrossRef
  • NNT‐induced tumor cell “slimming” reverses the pro‐carcinogenesis effect of HIF2a in tumors
    Zhiyong Xiong, Wei Xiong, Wen Xiao, Changfei Yuan, Jian Shi, Yu Huang, Cheng Wang, Xiangui Meng, Zhixian Chen, Hongmei Yang, Ke Chen, Xiaoping Zhang
    Clinical and Translational Medicine.2021;[Epub]     CrossRef
  • CD10 marks non-canonical PPARγ-independent adipocyte maturation and browning potential of adipose-derived stem cells
    Smarajit Chakraborty, Wee Kiat Ong, Winifred W. Y. Yau, Zhihong Zhou, K. N. Bhanu Prakash, Sue-Anne Toh, Weiping Han, Paul M. Yen, Shigeki Sugii
    Stem Cell Research & Therapy.2021;[Epub]     CrossRef
  • Regulatory roles of G-protein coupled receptors in adipose tissue metabolism and their therapeutic potential
    Hyeonyeong Im, Ji-Hyun Park, Seowoo Im, Juhyeong Han, Kyungmin Kim, Yun-Hee Lee
    Archives of Pharmacal Research.2021; 44(2): 133.     CrossRef
  • 3-N-butylphthalide protects against high-fat-diet-induced obesity in C57BL/6 mice and increases metabolism in lipid-accumulating cells
    Kang-Yun Lu, Shinn-Zong Lin, Kingsley Theras Primus Dass, Wei-Ju Lin, Shih-Ping Liu, Horng-Jyh Harn
    Biomedicine & Pharmacotherapy.2021; 139: 111687.     CrossRef
  • Ellagic acid induces beige remodeling of white adipose tissue by controlling mitochondrial dynamics and SIRT3
    Woo Yong Park, Jinbong Park, Kwang Seok Ahn, Hyun Jeong Kwak, Jae‐Young Um
    The FASEB Journal.2021;[Epub]     CrossRef
  • Cajanolactone A, a Stilbenoid From Cajanus canjan (L.) Millsp, Prevents High-Fat Diet-Induced Obesity via Suppressing Energy Intake
    Zhuohui Luo, Jiawen Huang, Zhiping Li, Zhiwen Liu, Linchun Fu, Yingjie Hu, Xiaoling Shen
    Frontiers in Pharmacology.2021;[Epub]     CrossRef
  • Zinc and the Innovative Zinc-α2-Glycoprotein Adipokine Play an Important Role in Lipid Metabolism: A Critical Review
    Michalina Banaszak, Ilona Górna, Juliusz Przysławski
    Nutrients.2021; 13(6): 2023.     CrossRef
  • Natural products in the management of obesity: Fundamental mechanisms and pharmacotherapy
    Yinghan Chan, Sin Wi Ng, Joycelin Zhu Xin Tan, Gaurav Gupta, Poonam Negi, Lakshmi Thangavelu, Sri Renukadevi Balusamy, Haribalan Perumalsamy, Wei Hsum Yap, Sachin Kumar Singh, Vanni Caruso, Kamal Dua, Dinesh Kumar Chellappan
    South African Journal of Botany.2021; 143: 176.     CrossRef
  • Group IIA secreted phospholipase A2 (PLA2G2A) augments adipose tissue thermogenesis
    Michael S. Kuefner, Erin Stephenson, Mladen Savikj, Heather S. Smallwood, Qingming Dong, Christine Payré, Gérard Lambeau, Edwards A. Park
    The FASEB Journal.2021;[Epub]     CrossRef
  • N-butylidenephthalide ameliorates high-fat diet-induced obesity in mice and promotes browning through adrenergic response/AMPK activation in mouse beige adipocytes
    Kang-Yun Lu, Kingsley Theras Primus Dass, Shinn-Zong Lin, Yu-Hua Tseng, Shih-Ping Liu, Horng-Jyh Harn
    Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids.2021; 1866(12): 159033.     CrossRef
  • Green tea aqueous extract (GTAE) prevents high‐fat diet‐induced obesity by activating fat browning
    Jie Li, Qiyang Chen, Xiuming Zhai, Dan Wang, Yujia Hou, Min Tang
    Food Science & Nutrition.2021; 9(12): 6548.     CrossRef
  • Ipragliflozin, an SGLT2 Inhibitor, Ameliorates High-Fat Diet-Induced Metabolic Changes by Upregulating Energy Expenditure through Activation of the AMPK/ SIRT1 Pathway
    Ji-Yeon Lee, Minyoung Lee, Ji Young Lee, Jaehyun Bae, Eugene Shin, Yong-ho Lee, Byung-Wan Lee, Eun Seok Kang, Bong-Soo Cha
    Diabetes & Metabolism Journal.2021; 45(6): 921.     CrossRef
  • The increase of uncoupling protein-1 expression after moderate intensity continuous exercises in obese females
    Sugiharto, Banih Sakti Adji, Desiana Merawati, Adi Pranoto
    Jurnal SPORTIF : Jurnal Penelitian Pembelajaran.2021; 7(2): 194.     CrossRef
  • Effects of Royal Jelly and Tocotrienol Rich Fraction in obesity treatment of calorie-restricted obese rats: a focus on white fat browning properties and thermogenic capacity
    Naimeh Mesri Alamdari, Pardis Irandoost, Neda Roshanravan, Mohammadreza Vafa, Mohammad Asghari Jafarabadi, Shahriar Alipour, Leila Roshangar, Mohammadreza Alivand, Farnaz Farsi, Farzad Shidfar
    Nutrition & Metabolism.2020;[Epub]     CrossRef
  • Metabolic Benefits of MicroRNA-22 Inhibition
    Marc Thibonnier, Christine Esau
    Nucleic Acid Therapeutics.2020; 30(2): 104.     CrossRef
  • Grape pomace extract supplementation activates FNDC5/irisin in muscle and promotes white adipose browning in rats fed a high-fat diet
    Cecilia Rodriguez Lanzi, Diahann J. Perdicaro, Julián Gambarte Tudela, Victoria Muscia, Ariel R. Fontana, Patricia I. Oteiza, Marcela A. Vazquez Prieto
    Food & Function.2020; 11(2): 1537.     CrossRef
  • Citrus aurantium L. polymethoxyflavones promote thermogenesis of brown and white adipose tissue in high-fat diet induced C57BL/6J mice
    Guangning Kou, Yan Hu, Zixiao Jiang, Zhenqing Li, Peiyuan Li, Hongjie Song, Qiyang Chen, Zhiqin Zhou, Quanjun Lyu
    Journal of Functional Foods.2020; 67: 103860.     CrossRef
  • Beneficial effects of pomegranate peel extract treatment on anthropometry and body composition of overweight patients with diabetes mellitus type-2: A randomised clinical trial
    Milkica Grabež, Ranko Škrbić, Miloš Stojiljković, Vesna Rudić-Grujić, Katarina Šavikin, Nebojša Menković, Gordana Zdunić, Nađa Vasiljević
    Scripta Medica.2020; 51(1): 21.     CrossRef
  • Milk fat globule membrane and its component phosphatidylcholine induce adipose browning both in vivo and in vitro
    Tiange Li, Min Du, Hanning Wang, Xueying Mao
    The Journal of Nutritional Biochemistry.2020; 81: 108372.     CrossRef
  • Dynamic contrast‐enhanced MRI of brown and beige adipose tissues
    Jadegoud Yaligar, Sanjay Kumar Verma, Venkatesh Gopalan, Rengaraj Anantharaj, Giang Thi Thu Le, Kavita Kaur, Karthik Mallilankaraman, MK Leow, SS Velan
    Magnetic Resonance in Medicine.2020; 84(1): 384.     CrossRef
  • Taurine Stimulates Thermoregulatory Genes in Brown Fat Tissue and Muscle without an Influence on Inguinal White Fat Tissue in a High-Fat Diet-Induced Obese Mouse Model
    Kyoung Soo Kim, Hari Madhuri Doss, Hee-Jin Kim, Hyung-In Yang
    Foods.2020; 9(6): 688.     CrossRef
  • White adipose tissue browning in critical illness: A review of the evidence, mechanisms and future perspectives
    Elham Alipoor, Mohammad Javad Hosseinzadeh‐Attar, Mahsa Rezaei, Shima Jazayeri, Marianne Chapman
    Obesity Reviews.2020;[Epub]     CrossRef
  • Metabolic and energetic benefits of microRNA-22 inhibition
    Marc Thibonnier, Christine Esau, Sujoy Ghosh, Edward Wargent, Claire Stocker
    BMJ Open Diabetes Research & Care.2020; 8(1): e001478.     CrossRef
  • Apple polyphenols induce browning of white adipose tissue
    Yuki Tamura, Shigeto Tomiya, Junya Takegaki, Karina Kouzaki, Arata Tsutaki, Koichi Nakazato
    The Journal of Nutritional Biochemistry.2020; 77: 108299.     CrossRef
  • Adipose TBX1 regulates β-adrenergic sensitivity in subcutaneous adipose tissue and thermogenic capacity in vivo
    Kathleen R. Markan, Lauren K. Boland, Abdul Qaadir King-McAlpin, Kristin E. Claflin, Michael P. Leaman, Morgan K. Kemerling, Madison M. Stonewall, Brad A. Amendt, James A. Ankrum, Matthew J. Potthoff
    Molecular Metabolism.2020; 36: 100965.     CrossRef
  • A systematic review of the association of neuregulin 4, a brown fat–enriched secreted factor, with obesity and related metabolic disturbances
    Helda Tutunchi, Alireza Ostadrahimi, Mohammad‐Javad Hosseinzadeh‐Attar, Mahsa Miryan, Majid Mobasseri, Mehrangiz Ebrahimi‐Mameghani
    Obesity Reviews.2020;[Epub]     CrossRef
  • Deficiency of glutathione peroxidase-1 and catalase attenuated diet-induced obesity and associated metabolic disorders
    Hyung-Ran Kim, Eun-Jeong Choi, Jeong-Hae Kie, Joo-Ho Lee, Ju-Young Seoh
    Acta Diabetologica.2020; 57(2): 151.     CrossRef
  • Clinical Application Potential of Small Molecules that Induce Brown Adipose Tissue Thermogenesis by Improving Fat Metabolism
    Kang-Yun Lu, Kingsley Theras Primus Dass, Sheng-Feng Tsai, Hong-Meng Chuang, Shinn-Zong Lin, Shih-Ping Liu, Horng-Jyh Harn
    Cell Transplantation.2020; 29: 096368972092739.     CrossRef
  • MiR‐92a regulates brown adipocytes differentiation, mitochondrial oxidative respiration, and heat generation by targeting SMAD7
    Zhipin Zhang, Huixin Jiang, Xiang Li, Xiaomin Chen, Yihua Huang
    Journal of Cellular Biochemistry.2020; 121(8-9): 3825.     CrossRef
  • Bilirubin remodels murine white adipose tissue by reshaping mitochondrial activity and the coregulator profile of peroxisome proliferator–activated receptor α
    Darren M. Gordon, Kari L. Neifer, Abdul-Rizaq Ali Hamoud, Charles F. Hawk, Andrea L. Nestor-Kalinoski, Scott A. Miruzzi, Michael P. Morran, Samuel O. Adeosun, Jeffrey G. Sarver, Paul W. Erhardt, Robert E. McCullumsmith, David E. Stec, Terry D. Hinds
    Journal of Biological Chemistry.2020; 295(29): 9804.     CrossRef
  • The Presence of Active Brown Adipose Tissue Determines Cold-Induced Energy Expenditure and Oxylipin Profiles in Humans
    Oana C Kulterer, Laura Niederstaetter, Carsten T Herz, Alexander R Haug, Andrea Bileck, Dietmar Pils, Alexandra Kautzky-Willer, Christopher Gerner, Florian W Kiefer
    The Journal of Clinical Endocrinology & Metabolism.2020; 105(7): 2203.     CrossRef
  • Downregulation of osteopontin inhibits browning of white adipose tissues through PI3K-AKT pathway in C57BL / 6 mice
    Yi Lu, Yuhong Xu, Wanwan Yuan, Mengxi Wang, Yumeng Zhou, Kai Chen, Qiren Huang
    European Journal of Pharmacology.2020; 866: 172822.     CrossRef
  • Angiotensin AT1 receptor antagonism by losartan stimulates adipocyte browning via induction of apelin
    Dong Young Kim, Mi Jin Choi, Tae Kyung Ko, Na Hyun Lee, Ok-Hee Kim, Hyae Gyeong Cheon
    Journal of Biological Chemistry.2020; 295(44): 14878.     CrossRef
  • Isoliquiritigenin Enhances the Beige Adipocyte Potential of Adipose-Derived Stem Cells by JNK Inhibition
    Hanbyeol Moon, Jung-Won Choi, Byeong-Wook Song, Il-Kwon Kim, Soyeon Lim, Seahyoung Lee, Ki-Chul Hwang, Sang Woo Kim
    Molecules.2020; 25(23): 5660.     CrossRef
  • In vitro evaluation of Hydrilla verticillata for anti-adipogenesis activity on 3T3 L1 cell lines
    SPandi Prabha, S Sadhana, C Karthik, DG Caroline
    Pharmacognosy Magazine.2020; 16(5): 498.     CrossRef
  • Leptin Promotes White Adipocyte Browning by Inhibiting the Hh Signaling Pathway
    Jie Wang, Jing Ge, Haigang Cao, Xiaoyu Zhang, Yuan Guo, Xiao Li, Bo Xia, Gongshe Yang, Xin’e Shi
    Cells.2019; 8(4): 372.     CrossRef
  • Impact of Gut Microbiota on Host Glycemic Control
    Céline Gérard, Hubert Vidal
    Frontiers in Endocrinology.2019;[Epub]     CrossRef
  • Effect of resveratrol on adipokines and myokines involved in fat browning: Perspectives in healthy weight against obesity
    Oh Yoen Kim, Ji Yeon Chung, Juhyun Song
    Pharmacological Research.2019; 148: 104411.     CrossRef
  • A comprehensive diagnostic approach to detect underlying causes of obesity in adults
    Eline S. van der Valk, Erica L.T. van den Akker, Mesut Savas, Lotte Kleinendorst, Jenny A. Visser, Mieke M. Van Haelst, Arya M. Sharma, Elisabeth F.C. van Rossum
    Obesity Reviews.2019; 20(6): 795.     CrossRef
  • Prostacyclin: A major prostaglandin in the regulation of adipose tissue development
    Mohammad Sharifur Rahman
    Journal of Cellular Physiology.2019; 234(4): 3254.     CrossRef
  • The expression of brown fat‐associated proteins in colorectal cancer and the relationship of uncoupling protein 1 with prognosis
    Abdo Alnabulsi, Beatriz Cash, Yehfang Hu, Linda Silina, Ayham Alnabulsi, Graeme I. Murray
    International Journal of Cancer.2019; 145(4): 1138.     CrossRef
  • Garlic augments the functional and nutritional behavior of Doenjang, a traditional Korean fermented soybean paste
    Ashutosh Bahuguna, Shruti Shukla, Jong Suk Lee, Vivek K. Bajpai, So-Young Kim, Yun Suk Huh, Young-Kyu Han, Myunghee Kim
    Scientific Reports.2019;[Epub]     CrossRef
  • Clomiphene promotes browning of white adipocytes via casein kinase-2 inhibition
    Hyun-Jin Kim, Dong Young Kim, Hyae Gyeong Cheon
    European Journal of Pharmacology.2019; 861: 172596.     CrossRef
  • Neuroendocrine Regulation of Energy Metabolism Involving Different Types of Adipose Tissues
    Qi Zhu, Bradley J. Glazier, Benjamin C. Hinkel, Jingyi Cao, Lin Liu, Chun Liang, Haifei Shi
    International Journal of Molecular Sciences.2019; 20(11): 2707.     CrossRef
  • Tumor Cell “Slimming” Regulates Tumor Progression through PLCL1/UCP1‐Mediated Lipid Browning
    Zhiyong Xiong, Wen Xiao, Lin Bao, Wei Xiong, Haibing Xiao, Yan Qu, Changfei Yuan, Hailong Ruan, Qi Cao, Keshan Wang, Zhengshuai Song, Cheng Wang, Wenjun Hu, Zeyuan Ru, Junwei Tong, Gong Cheng, Tianbo Xu, Xiangui Meng, Jian Shi, Zhixian Chen, Hongmei Yang,
    Advanced Science.2019;[Epub]     CrossRef
  • Soyasaponin Ab alleviates postmenopausal obesity through browning of white adipose tissue
    Han-Jun Kim, Eun-Ji Choi, Hyo Sung Kim, Chan-Woong Choi, Sik-Won Choi, Sun-Lim Kim, Woo-Duck Seo, Sun Hee Do
    Journal of Functional Foods.2019; 57: 453.     CrossRef
  • Beneficial Effects of Pomegranate Peel Extract and Probiotics on Pre-adipocyte Differentiation
    Valeria Sorrenti, Cinzia Lucia Randazzo, Cinzia Caggia, Gabriele Ballistreri, Flora Valeria Romeo, Simona Fabroni, Nicolina Timpanaro, Marco Raffaele, Luca Vanella
    Frontiers in Microbiology.2019;[Epub]     CrossRef
  • Visfatin; a potential novel mediator of brown adipose tissue
    Parmida Pourvali-Talatappeh, Elham Alipoor
    Obesity Medicine.2019; 15: 100122.     CrossRef
  • Strategies and methods for the correction of obesity and associated cardiovascular risk
    T. Yu. Kuznetsova, M. A. Druzhilov, G. A. Chumakova, N. D. Veselovskaya
    Russian Journal of Cardiology.2019; (4): 61.     CrossRef
  • Polymeric Carriers for Controlled Drug Delivery in Obesity Treatment
    Di Huang, Meng Deng, Shihuan Kuang
    Trends in Endocrinology & Metabolism.2019; 30(12): 974.     CrossRef
  • Tbx15 is required for adipocyte browning induced by adrenergic signaling pathway
    Wei Sun, Xuemei Zhao, Zhengqi Wang, Yi Chu, Liufeng Mao, Shaoqiang Lin, Xuefei Gao, Yuna Song, Xiaoyan Hui, Shiqi Jia, Shibing Tang, Yong Xu, Aimin Xu, Kerry Loomes, Cunchuan Wang, Donghai Wu, Tao Nie
    Molecular Metabolism.2019; 28: 48.     CrossRef
  • Effects of caloric restriction on the expression of lipocalin-2 and its receptor in the brown adipose tissue of high-fat diet-fed mice
    Kyung-Ah Park, Zhen Jin, Hyeong Seok An, Jong Youl Lee, Eun Ae Jeong, Eun Bee Choi, Kyung Eun Kim, Hyun Joo Shin, Jung Eun Lee, Gu Seob Roh
    The Korean Journal of Physiology & Pharmacology.2019; 23(5): 335.     CrossRef
  • Peripherally administered melanocortins induce mice fat browning and prevent obesity
    Adriana R. Rodrigues, Maria J. Salazar, Sílvia Rocha-Rodrigues, Inês O. Gonçalves, Célia Cruz, Delminda Neves, Henrique Almeida, José Magalhães, Alexandra M. Gouveia
    International Journal of Obesity.2019; 43(5): 1058.     CrossRef
  • Chinese medicine Jinlida granules improve high-fat-diet induced metabolic disorders via activation of brown adipose tissue in mice
    Hui Zhang, Yuanyuan Hao, Cong Wei, Bing Yao, Shen Liu, Hongru Zhou, Dan Huang, Chuanhai Zhang, Yiling Wu
    Biomedicine & Pharmacotherapy.2019; 114: 108781.     CrossRef
  • Effects of lobeglitazone, a novel thiazolidinedione, on adipose tissue remodeling and brown and beige adipose tissue development in db/db mice
    G Kim, Y-h Lee, M R Yun, J-Y Lee, E G Shin, B-W Lee, E S Kang, B-S Cha
    International Journal of Obesity.2018; 42(3): 542.     CrossRef
  • Air Pollution Has a Significant Negative Impact on Intentional Efforts to Lose Weight: A Global Scale Analysis
    Morena Ustulin, So Young Park, Sang Ouk Chin, Suk Chon, Jeong-taek Woo, Sang Youl Rhee
    Diabetes & Metabolism Journal.2018; 42(4): 320.     CrossRef
  • Phytol stimulates the browning of white adipocytes through the activation of AMP-activated protein kinase (AMPK) α in mice fed high-fat diet
    Fenglin Zhang, Wei Ai, Xiaoquan Hu, Yingying Meng, Cong Yuan, Han Su, Lina Wang, Xiaotong Zhu, Ping Gao, Gang Shu, Qingyan Jiang, Songbo Wang
    Food & Function.2018; 9(4): 2043.     CrossRef
  • Nobiletin induces brown adipocyte-like phenotype and ameliorates stress in 3T3-L1 adipocytes
    Jameel Lone, Hilal Ahmad Parray, Jong Won Yun
    Biochimie.2018; 146: 97.     CrossRef
  • Regular aerobic exercise correlates with reduced anxiety and incresed levels of irisin in brain and white adipose tissue
    Nazan Uysal, Oguz Yuksel, Servet Kizildag, Zeynep Yuce, Hikmet Gumus, Aslı Karakilic, Guven Guvendi, Basar Koc, Sevim Kandis, Mehmet Ates
    Neuroscience Letters.2018; 676: 92.     CrossRef
  • The Root of Atractylodes macrocephala Koidzumi Prevents Obesity and Glucose Intolerance and Increases Energy Metabolism in Mice
    Mi Song, Soo-Kyoung Lim, Jing-Hua Wang, Hojun Kim
    International Journal of Molecular Sciences.2018; 19(1): 278.     CrossRef
  • Differential actions of PPAR-α and PPAR-β/δ on beige adipocyte formation: A study in the subcutaneous white adipose tissue of obese male mice
    Tamiris Lima Rachid, Flavia Maria Silva-Veiga, Francielle Graus-Nunes, Isabele Bringhenti, Carlos Alberto Mandarim-de-Lacerda, Vanessa Souza-Mello, Nobuyuki Takahashi
    PLOS ONE.2018; 13(1): e0191365.     CrossRef
  • Coordination Among Lipid Droplets, Peroxisomes, and Mitochondria Regulates Energy Expenditure Through the CIDE-ATGL-PPARα Pathway in Adipocytes
    Linkang Zhou, Miao Yu, Muhammad Arshad, Wenmin Wang, Ye Lu, Jingyi Gong, Yangnan Gu, Peng Li, Li Xu
    Diabetes.2018; 67(10): 1935.     CrossRef
  • Lithocholic Acid Improves the Survival of Drosophila Melanogaster
    Stefanie Staats, Gerald Rimbach, Axel Kuenstner, Simon Graspeuntner, Jan Rupp, Hauke Busch, Christian Sina, Ignacio R. Ipharraguerre, Anika E. Wagner
    Molecular Nutrition & Food Research.2018;[Epub]     CrossRef
  • Preconditioning lessens high fat induced metabolic syndrome along with markers of increased metabolic capacity in muscle and adipose tissue
    Songpei Li, Xiu Zhou, Eunjung Jo, Ali Mahzari, Sherouk Fouda, Dongli Li, Kun Zhang, Ji-Ming Ye
    Bioscience Reports.2018;[Epub]     CrossRef
  • Alternative mRNA Splicing in the Pathogenesis of Obesity
    Chi-Ming Wong, Lu Xu, Mabel Yau
    International Journal of Molecular Sciences.2018; 19(2): 632.     CrossRef
  • Krüppel-Like Factors
    Nina M. Pollak, Matthew Hoffman, Ira J. Goldberg, Konstantinos Drosatos
    JACC: Basic to Translational Science.2018; 3(1): 132.     CrossRef
  • Dietary n-3 long-chain polyunsaturated fatty acids upregulate energy dissipating metabolic pathways conveying anti-obesogenic effects in mice
    Stefanie Worsch, Mathias Heikenwalder, Hans Hauner, Bernhard L. Bader
    Nutrition & Metabolism.2018;[Epub]     CrossRef
  • Combination of Capsaicin and Hesperidin Reduces the Effectiveness of Each Compound To Decrease the Adipocyte Size and To Induce Browning Features in Adipose Tissue of Western Diet Fed Rats
    Andrea Mosqueda-Solís, Juana Sánchez, María P. Portillo, Andreu Palou, Catalina Picó
    Journal of Agricultural and Food Chemistry.2018; 66(37): 9679.     CrossRef
  • Regulation of Adipose Tissue Metabolism by the Endocannabinoid System
    Robin van Eenige, Mario van der Stelt, Patrick C.N. Rensen, Sander Kooijman
    Trends in Endocrinology & Metabolism.2018; 29(5): 326.     CrossRef
  • Cardiovascular and Metabolic Heterogeneity of Obesity
    Ian J. Neeland, Paul Poirier, Jean-Pierre Després
    Circulation.2018; 137(13): 1391.     CrossRef
  • Zinc alpha2 glycoprotein promotes browning in adipocytes
    Xin-Hua Xiao, Xiao-Yan Qi, Ya-Di Wang, Li Ran, Jing Yang, Huan-Li Zhang, Can-Xin Xu, Ge-Bo Wen, Jiang-Hua Liu
    Biochemical and Biophysical Research Communications.2018; 496(2): 287.     CrossRef
  • Impacts of High Sodium Intake on Obesity-related Gene Expression
    Minjee Lee, Miyoung Park, Juhee Kim, Soyoung Sung, Myoungsook Lee
    Journal of the East Asian Society of Dietary Life.2018; 28(5): 364.     CrossRef
  • Programming mediated by fatty acids affects uncoupling protein 1 (UCP-1) in brown adipose tissue
    Perla P. Argentato, Helena de Cássia César, Débora Estadella, Luciana P. Pisani
    British Journal of Nutrition.2018; 120(6): 619.     CrossRef
  • Reversal of Fatty Infiltration After Suprascapular Nerve Compression Release Is Dependent on UCP1 Expression in Mice
    Zili Wang, Brian T. Feeley, Hubert T. Kim, Xuhui Liu
    Clinical Orthopaedics & Related Research.2018; 476(8): 1665.     CrossRef
  • Increase in relative skeletal muscle mass over time and its inverse association with metabolic syndrome development: a 7-year retrospective cohort study
    Gyuri Kim, Seung-Eun Lee, Ji Eun Jun, You-Bin Lee, Jiyeon Ahn, Ji Cheol Bae, Sang-Man Jin, Kyu Yeon Hur, Jae Hwan Jee, Moon-Kyu Lee, Jae Hyeon Kim
    Cardiovascular Diabetology.2018;[Epub]     CrossRef
  • Myricetin-induced brown adipose tissue activation prevents obesity and insulin resistance in db/db mice
    Tao Hu, Xiaoxue Yuan, Gang Wei, Haoshu Luo, Hyuek Jong Lee, Wanzhu Jin
    European Journal of Nutrition.2018; 57(1): 391.     CrossRef
  • Effects of growth hormone on uncoupling protein 1 in white adipose tissues in obese mice
    Misa Hayashi, Kumi Futawaka, Rie Koyama, Yue Fan, Midori Matsushita, Asuka Hirao, Yuki Fukuda, Ayako Nushida, Syoko Nezu, Tetsuya Tagami, Kenji Moriyama
    Growth Hormone & IGF Research.2017; 37: 31.     CrossRef
  • Position paper of the European Society of Cardiology–working group of coronary pathophysiology and microcirculation: obesity and heart disease
    Lina Badimon, Raffaele Bugiardini, Edina Cenko, Judit Cubedo, Maria Dorobantu, Dirk J. Duncker, Ramón Estruch, Davor Milicic, Dimitris Tousoulis, Zorana Vasiljevic, Gemma Vilahur, Cor de Wit, Akos Koller
    European Heart Journal.2017; 38(25): 1951.     CrossRef
  • Browning of Abdominal Aorta Perivascular Adipose Tissue Inhibits Adipose Tissue Inflammation
    Run-Mei Li, Sui-Qing Chen, Ning-Xi Zeng, Shu-Hui Zheng, Li Guan, Hai-Mei Liu, Le-Quan Zhou, Jin-Wen Xu
    Metabolic Syndrome and Related Disorders.2017; 15(9): 450.     CrossRef
  • The role of adipose tissue in cancer-associated cachexia
    Janina A Vaitkus, Francesco S Celi
    Experimental Biology and Medicine.2017; 242(5): 473.     CrossRef
  • Hormonal factors in the control of the browning of white adipose tissue
    Jiamiao Hu, Mark Christian
    Hormone Molecular Biology and Clinical Investigation.2017;[Epub]     CrossRef
  • European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)
    Javier Egea, Isabel Fabregat, Yves M. Frapart, Pietro Ghezzi, Agnes Görlach, Thomas Kietzmann, Kateryna Kubaichuk, Ulla G. Knaus, Manuela G. Lopez, Gloria Olaso-Gonzalez, Andreas Petry, Rainer Schulz, Jose Vina, Paul Winyard, Kahina Abbas, Opeyemi S. Adem
    Redox Biology.2017; 13: 94.     CrossRef
  • Resveratrol enhances brown adipocyte formation and function by activating AMP‐activated protein kinase (AMPK) α1 in mice fed high‐fat diet
    Songbo Wang, Xingwei Liang, Qiyuan Yang, Xing Fu, Meijun Zhu, B. D. Rodgers, Qingyan Jiang, Michael V. Dodson, Min Du
    Molecular Nutrition & Food Research.2017;[Epub]     CrossRef
  • Adipoz doku ve enerji metabolizması üzerine etkileri
    Meltem Mermer, Nilüfer Acar TEK
    SDÜ Sağlık Bilimleri Dergisi.2017;[Epub]     CrossRef
  • Physiological roles of macrophages
    Siamon Gordon, Luisa Martinez-Pomares
    Pflügers Archiv - European Journal of Physiology.2017; 469(3-4): 365.     CrossRef
  • Brown Adipose Tissue Bioenergetics: A New Methodological Approach
    María Calderon‐Dominguez, Martín Alcalá, David Sebastián, Antonio Zorzano, Marta Viana, Dolors Serra, Laura Herrero
    Advanced Science.2017;[Epub]     CrossRef
  • Honokiol exerts dual effects on browning and apoptosis of adipocytes
    Jameel Lone, Jong Won Yun
    Pharmacological Reports.2017; 69(6): 1357.     CrossRef
  • The Mixed Herbal Extract, CAPA, Prevents Obesity and Glucose Intolerance in Obese Mice
    Miyoung Song
    Journal of Korean Medicine for Obesity Research.2017; 17(2): 119.     CrossRef
  • Brown Adipose Tissue: an Update on Recent Findings
    Kara L. Marlatt, Eric Ravussin
    Current Obesity Reports.2017; 6(4): 389.     CrossRef
  • Radix Stellariae extract prevents high-fat-diet-induced obesity in C57BL/6 mice by accelerating energy metabolism
    Yin Li, Xin Liu, Yu Fan, Baican Yang, Cheng Huang
    PeerJ.2017; 5: e3305.     CrossRef
  • Adipocyte arrestin domain-containing 3 protein (Arrdc3) regulates uncoupling protein 1 (Ucp1) expression in white adipose independently of canonical changes in β-adrenergic receptor signaling
    Shannon H. Carroll, Ellen Zhang, Bing F. Wang, Katherine B. LeClair, Arifeen Rahman, David E. Cohen, Jorge Plutzky, Parth Patwari, Richard T. Lee, Makoto Kanzaki
    PLOS ONE.2017; 12(3): e0173823.     CrossRef
  • Effect of Long-Term Green Tea Extract Supplementation on Peripheral Blood Leukocytes in CrossFit-Trained and Untrained Men
    Agata Żak, Ilona Pokora
    Central European Journal of Sport Sciences and Medicine.2017; 19: 67.     CrossRef
  • Rapid modulation of lipid metabolism in C57BL/6J mice induced by eicosapentaenoic acid-enriched phospholipid from Cucumaria frondosa
    Lingyu Zhang, Dan Wang, Min Wen, Lei Du, Changhu Xue, Jingfeng Wang, Jie Xu, Yuming Wang
    Journal of Functional Foods.2017; 28: 28.     CrossRef
  • Egr1 deficiency induces browning of inguinal subcutaneous white adipose tissue in mice
    Cécile Milet, Marianne Bléher, Kassandra Allbright, Mickael Orgeur, Fanny Coulpier, Delphine Duprez, Emmanuelle Havis
    Scientific Reports.2017;[Epub]     CrossRef
  • Purinergic Receptors in Adipose Tissue As Potential Targets in Metabolic Disorders
    Marco Tozzi, Ivana Novak
    Frontiers in Pharmacology.2017;[Epub]     CrossRef
  • Phyllodulcin, a Natural Sweetener, Regulates Obesity-Related Metabolic Changes and Fat Browning-Related Genes of Subcutaneous White Adipose Tissue in High-Fat Diet-Induced Obese Mice
    Eunju Kim, Soo-Min Lim, Min-Soo Kim, Sang-Ho Yoo, Yuri Kim
    Nutrients.2017; 9(10): 1049.     CrossRef
  • Yogurt and Cardiometabolic Diseases: A Critical Review of Potential Mechanisms
    Melissa Anne Fernandez, Shirin Panahi, Noémie Daniel, Angelo Tremblay, André Marette
    Advances in Nutrition.2017; 8(6): 812.     CrossRef
  • Système endocannabinoïde : effets sur le métabolisme glucidique, mais aussi lipidique
    A.-L. Sberna, P. Degrace, B. Vergès
    Médecine des Maladies Métaboliques.2016; 10(5): 407.     CrossRef
  • The Fat Side of the Endocannabinoid System: Role of Endocannabinoids in the Adipocyte
    Isabelle Matias, Ilaria Belluomo, Daniela Cota
    Cannabis and Cannabinoid Research.2016; 1(1): 176.     CrossRef
  • Liraglutide suppresses obesity and induces brown fat-like phenotype via Soluble Guanylyl Cyclase mediated pathwayin vivoandin vitro
    Endong Zhu, Yang Yang, Juanjuan Zhang, Yongmei Li, Chunjun Li, Liming Chen, Bei Sun
    Oncotarget.2016; 7(49): 81077.     CrossRef
  • NS5ATP6 modulates intracellular triglyceride content through FGF21 and independently of SIRT1 and SREBP1
    Zhongshu Li, Shenghu Feng, Li Zhou, Shunai Liu, Jun Cheng
    Biochemical and Biophysical Research Communications.2016; 475(1): 133.     CrossRef
  • Novel device for male infertility screening with single-ball lens microscope and smartphone
    Yoshitomo Kobori, Peter Pfanner, Gail S. Prins, Craig Niederberger
    Fertility and Sterility.2016; 106(3): 574.     CrossRef
  • An Intestinal Microbiota–Farnesoid X Receptor Axis Modulates Metabolic Disease
    Frank J. Gonzalez, Changtao Jiang, Andrew D. Patterson
    Gastroenterology.2016; 151(5): 845.     CrossRef
  • Feast and famine: Adipose tissue adaptations for healthy aging
    Daniele Lettieri Barbato, Katia Aquilano
    Ageing Research Reviews.2016; 28: 85.     CrossRef
  • Hypothalamus and thermogenesis: Heating the BAT, browning the WAT
    Cristina Contreras, Rubén Nogueiras, Carlos Diéguez, Gema Medina-Gómez, Miguel López
    Molecular and Cellular Endocrinology.2016; 438: 107.     CrossRef
  • Concomitant beige adipocyte differentiation upon induction of mesenchymal stem cells into brown adipocytes
    Yung-Li Wang, Shih-Pei Lin, Patrick C.H. Hsieh, Shih-Chieh Hung
    Biochemical and Biophysical Research Communications.2016; 478(2): 689.     CrossRef
Fibroblast Growth Factor 21 Protects against Atherosclerosis via Fine-Tuning the Multiorgan Crosstalk
Leigang Jin, Zhuofeng Lin, Aimin Xu
Diabetes Metab J. 2016;40(1):22-31.   Published online January 29, 2016
DOI: https://doi.org/10.4093/dmj.2016.40.1.22
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AbstractAbstract PDFPubReader   

Fibroblast growth factor 21 (FGF21) is a metabolic hormone with pleiotropic effects on energy metabolism and insulin sensitivity. Besides its antiobese and antidiabetic activity, FGF21 also possesses the protective effects against atherosclerosis. Circulating levels of FGF21 are elevated in patients with atherosclerosis, macrovascular and microvascular complications of diabetes, possibly due to a compensatory upregulation. In apolipoprotein E-deficient mice, formation of atherosclerotic plaques is exacerbated by genetic depletion of FGF21, but is attenuated upon replenishment with recombinant FGF21. However, the blood vessel is not the direct target of FGF21, and the antiatherosclerotic activity of FGF21 is attributed to its actions in adipose tissues and liver. In adipocytes, FGF21 promotes secretion of adiponectin, which in turn acts directly on blood vessels to reduce endothelial dysfunction, inhibit proliferation of smooth muscle cells and block conversion of macrophages to foam cells. Furthermore, FGF21 suppresses cholesterol biosynthesis and attenuates hypercholesterolemia by inhibiting the transcription factor sterol regulatory element-binding protein-2 in hepatocytes. The effects of FGF21 on elevation of adiponectin and reduction of hypercholesterolemia are also observed in a phase-1b clinical trial in patients with obesity and diabetes. Therefore, FGF21 exerts its protection against atherosclerosis by fine-tuning the interorgan crosstalk between liver, brain, adipose tissue, and blood vessels.

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  • Fibroblast Growth Factor–Based Pharmacotherapies for the Treatment of Obesity-Related Metabolic Complications
    Leigang Jin, Ranyao Yang, Leiluo Geng, Aimin Xu
    Annual Review of Pharmacology and Toxicology.2023; 63(1): 359.     CrossRef
  • Efruxifermin, an investigational treatment for fibrotic or cirrhotic nonalcoholic steatohepatitis (NASH)
    Tobias Puengel, Frank Tacke
    Expert Opinion on Investigational Drugs.2023; 32(6): 451.     CrossRef
  • The role of perivascular adipose tissue-secreted adipocytokines in cardiovascular disease
    Meichao Cai, Dongsheng Zhao, Xiao Han, Shuang Han, Wenxin Zhang, Zhennan Zang, Chenchen Gai, Rong Rong, Tian Gao
    Frontiers in Immunology.2023;[Epub]     CrossRef
  • Pharmacological treatment with FGF21 strongly improves plasma cholesterol metabolism to reduce atherosclerosis
    Cong Liu, Milena Schönke, Enchen Zhou, Zhuang Li, Sander Kooijman, Mariëtte R Boon, Mikael Larsson, Kristina Wallenius, Niek Dekker, Louise Barlind, Xiao-Rong Peng, Yanan Wang, Patrick C N Rensen
    Cardiovascular Research.2022; 118(2): 489.     CrossRef
  • Relationship between Serum FGF21 and vWF Expression and Carotid Atherosclerosis in Elderly Patients with Hypertension
    Jing Bian, Lairong Chen, Qin Li, Yunfeng Zhao, Delu Yin, Shanhong Sun, Bhagyaveni M.A
    Journal of Healthcare Engineering.2022; 2022: 1.     CrossRef
  • Serum FGF21 Levels Predict the MACE in Patients With Myocardial Infarction After Coronary Artery Bypass Graft Surgery
    Wei Xie, Dan Li, Yaru Shi, Ning Yu, Yu Yan, Yingchao Zhang, Qiongli Yu, Yulin Li, Jie Du, Zhuofeng Lin, Fan Wu
    Frontiers in Cardiovascular Medicine.2022;[Epub]     CrossRef
  • Adipokines, adiposity, and atherosclerosis
    Longhua Liu, Zunhan Shi, Xiaohui Ji, Wenqian Zhang, Jinwen Luan, Tarik Zahr, Li Qiang
    Cellular and Molecular Life Sciences.2022;[Epub]     CrossRef
  • Current understanding and controversies on the clinical implications of fibroblast growth factor 21
    Yasaman Badakhshi, Tianru Jin
    Critical Reviews in Clinical Laboratory Sciences.2021; 58(5): 311.     CrossRef
  • The potential role of plasma fibroblast growth factor 21 as a diagnostic biomarker for abdominal aortic aneurysm presence and development
    Ting Xie, Liangying Yin, Dan Guo, Zixin Zhang, Yuexin Chen, Bao Liu, Wei Wang, Yuehong Zheng
    Life Sciences.2021; 274: 119346.     CrossRef
  • Ultrasound-assisted C3F8-filled PLGA nanobubbles for enhanced FGF21 delivery and improved prophylactic treatment of diabetic cardiomyopathy
    Jiameng Gao, Jingjing Liu, Zheying Meng, Yanming Li, Yuping Hong, Lirui Wang, Lan He, Bing Hu, Yuanyi Zheng, Tianliang Li, Daxiang Cui, E. Shen
    Acta Biomaterialia.2021; 130: 395.     CrossRef
  • Effect of Fibroblast Growth Factor 21 on the Development of Atheromatous Plaque and Lipid Metabolic Profiles in an Atherosclerosis-Prone Mouse Model
    Hyo Jin Maeng, Gha Young Lee, Jae Hyun Bae, Soo Lim
    International Journal of Molecular Sciences.2020; 21(18): 6836.     CrossRef
  • The therapeutic potential of FGF21 in metabolic diseases: from bench to clinic
    Leiluo Geng, Karen S. L. Lam, Aimin Xu
    Nature Reviews Endocrinology.2020; 16(11): 654.     CrossRef
  • Two-hundred-liter scale fermentation, purification of recombinant human fibroblast growth factor-21, and its anti-diabetic effects on ob/ob mice
    Qi Hui, Zhen Huang, Shucai Pang, Xuanxin Yang, Jinghang Li, Bingjie Yu, Lu Tang, Xiaokun Li, Xiaojie Wang
    Applied Microbiology and Biotechnology.2019; 103(2): 719.     CrossRef
  • Fibroblast growth factor 21: A role in cardiometabolic disorders and cardiovascular risk prediction?
    Niki Katsiki, Christos Mantzoros
    Metabolism.2019; 93: iii.     CrossRef
  • Heparin‐poloxamer hydrogel‐encapsulated rhFGF21 enhances wound healing in diabetic mice
    Huan Liu, Yeli Zhao, Yuchi Zou, Wenting Huang, Liyun Zhu, Fei Liu, Dongxue Wang, Kaiming Guo, Jian Hu, Jun Chen, Lixia Ye, Xiaokun Li, Li Lin
    The FASEB Journal.2019; 33(9): 9858.     CrossRef
  • Fibroblast growth factor 21 association with subclinical atherosclerosis and arterial stiffness in type 2 diabetes
    Saeed Yafei, Fathy Elsewy, Eman Youssef, Mohammed Ayman, Mohamed El-Shafei
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2019; 13(1): 882.     CrossRef
  • Myokines in metabolic homeostasis and diabetes
    Jürgen Eckel
    Diabetologia.2019; 62(9): 1523.     CrossRef
  • Inhibition of vascular neointima hyperplasia by FGF21 associated with FGFR1/Syk/NLRP3 inflammasome pathway in diabetic mice
    Wei Wei, Xiao-Xue Li, Ming Xu
    Atherosclerosis.2019; 289: 132.     CrossRef
  • LY2405319, an analog of fibroblast growth factor 21 ameliorates α-smooth muscle actin production through inhibition of the succinate—G-protein couple receptor 91 (GPR91) pathway in mice
    Cong Thuc Le, Giang Nguyen, So Young Park, Dae Hee Choi, Eun-Hee Cho, Partha Mukhopadhyay
    PLOS ONE.2018; 13(2): e0192146.     CrossRef
  • Relationship of Selected Adipokines with Markers of Vascular Damage in Patients with Type 2 Diabetes
    Jaromíra Spurná, David Karásek, Veronika Kubíčková, Dominika Goldmannová, Ondřej Krystyník, Jan Schovánek, Josef Zadražil
    Metabolic Syndrome and Related Disorders.2018; 16(5): 246.     CrossRef
  • Serum FGF21 Is Associated with Future Cardiovascular Events in Patients with Coronary Artery Disease
    Yun Shen, Xueli Zhang, Yiting Xu, Qin Xiong, Zhigang Lu, Xiaojing Ma, Yuqian Bao, Weiping Jia
    Cardiology.2018; 139(4): 212.     CrossRef
  • Relationship between Circulating FGF21 Concentrations and the Severity of Coronary Artery Damage in Subjects with Cardiovascular Disease
    Sung Don Park, Kwi-Hyun Bae, Yeon-Kyung Choi, Jae-Han Jeon, Jung Beom Seo, Namkyun Kim, Chang-Yeon Kim, Sung Woo Kim, Won Kee Lee, Jung Guk Kim, In-Kyu Lee, Jang Hoon Lee, Keun-Gyu Park
    Journal of Lipid and Atherosclerosis.2018; 7(1): 42.     CrossRef
  • Fibroblast growth factor 21 regulates foam cells formation and inflammatory response in Ox-LDL-induced THP-1 macrophages
    Nan Wang, Jun-yan Li, Shuai Li, Xiao-chen Guo, Tong Wu, Wen-fei Wang, De-shan Li
    Biomedicine & Pharmacotherapy.2018; 108: 1825.     CrossRef
  • Chip‐based high resolution tandem mass spectrometric determination of fibroblast growth factor—chondroitin sulfate disaccharides noncovalent interaction
    Adrian C. Robu, Laurentiu Popescu, Daniela G. Seidler, Alina D. Zamfir
    Journal of Mass Spectrometry.2018; 53(7): 624.     CrossRef
  • Conditioned medium from contracting skeletal muscle cells reverses insulin resistance and dysfunction of endothelial cells
    Yihe Zhao, Nana Li, Zhu Li, Da Zhang, Liming Chen, Zhi Yao, Wenyan Niu
    Metabolism.2018; 82: 36.     CrossRef
  • Dietary n-3 long-chain polyunsaturated fatty acids upregulate energy dissipating metabolic pathways conveying anti-obesogenic effects in mice
    Stefanie Worsch, Mathias Heikenwalder, Hans Hauner, Bernhard L. Bader
    Nutrition & Metabolism.2018;[Epub]     CrossRef
  • Metabolic Values of Fibroblasts Growth Factor 21 in Patients with Coronary Artery Disease and Obesity
    L. M. Pasiyeshvili, K. V. Ivanova
    Ukraïnsʹkij žurnal medicini, bìologìï ta sportu.2018; 3(4): 110.     CrossRef
  • FGF21 activates AMPK signaling: impact on metabolic regulation and the aging process
    Antero Salminen, Anu Kauppinen, Kai Kaarniranta
    Journal of Molecular Medicine.2017; 95(2): 123.     CrossRef
  • Regulation of longevity by FGF21: Interaction between energy metabolism and stress responses
    Antero Salminen, Kai Kaarniranta, Anu Kauppinen
    Ageing Research Reviews.2017; 37: 79.     CrossRef
  • Contribution of serum FGF21 level to the identification of left ventricular systolic dysfunction and cardiac death
    Yun Shen, Xueli Zhang, Xiaoping Pan, Yiting Xu, Qin Xiong, Zhigang Lu, Xiaojing Ma, Yuqian Bao, Weiping Jia
    Cardiovascular Diabetology.2017;[Epub]     CrossRef
  • Fibroblast growth factor 21 – a key player in cardiovascular disorders?
    Monika Lenart-Lipińska, Dariusz Duma, Magdalena Hałabiś, Marcin Dziedzic, Janusz Solski
    Hormone Molecular Biology and Clinical Investigation.2017;[Epub]     CrossRef
  • The role of fibroblast growth factor 21 in atherosclerosis
    John Kokkinos, Shudi Tang, Kerry-Anne Rye, Kwok Leung Ong
    Atherosclerosis.2017; 257: 259.     CrossRef
Editorial
Others
Cystatin C as a Predictor for Diabetes according to Glycosylated Hemoglobin Levels in Korean Patients
Eon Ju Jeon, Ji Hyun Lee
Diabetes Metab J. 2016;40(1):32-34.   Published online February 19, 2016
DOI: https://doi.org/10.4093/dmj.2016.40.1.32
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PDFPubReader   

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  • Prognostic significance of serum cystatin C in acute brainstem infarctions patients
    H. Li, B. Zhang, Z. Huang, H. Wu, B. Qin, L. Zhou, Z. Lu, F. Qin
    Revue Neurologique.2024;[Epub]     CrossRef
  • To compare the level of cystatin C in type 2 diabetes mellitus with obesity
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    Indian Journal of Endocrinology and Metabolism.2020; 24(4): 312.     CrossRef
Original Articles
Epidemiology of Type 1 Diabetes Mellitus in Korea through an Investigation of the National Registration Project of Type 1 Diabetes for the Reimbursement of Glucometer Strips with Additional Analyses Using Claims Data
Sun Ok Song, Young Duk Song, Joo Young Nam, Kyeong Hye Park, Ji-Hae Yoon, Kyung-Mi Son, Young Ko, Dong-Ha Lim
Diabetes Metab J. 2016;40(1):35-45.   Published online December 1, 2015
DOI: https://doi.org/10.4093/dmj.2016.40.1.35
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AbstractAbstract PDFSupplementary MaterialPubReader   
Background

The aim of this study was to estimate the prevalence and incidence of type 1 diabetes mellitus (T1DM) in Korea. In addition, we planned to do a performance analysis of the Registration Project of Type 1 diabetes for the reimbursement of consumable materials.

Methods

To obtain nationwide data on the incidence and prevalence of T1DM, we extracted claims data from July 2011 to August 2013 from the Registration Project of Type 1 diabetes on the reimbursement of consumable materials in the National Health Insurance (NHI) Database. For a more detailed analysis of the T1DM population in Korea, stratification by gender, age, and area was performed, and prevalence and incidence were calculated.

Results

Of the 8,256 subjects enrolled over the 26 months, the male to female ratio was 1 to 1.12, the median age was 37.1 years, and an average of 136 new T1DM patients were registered to the T1DM registry each month, resulting in 1,632 newly diagnosed T1DM patients each year. We found that the incidence rate of new T1DM cases was 3.28 per 100,000 people. The average proportion of T1DM patients compared with each region's population was 0.0125%. The total number of insurance subscribers under the universal compulsory NHI in Korea was 49,662,097, and the total number of diabetes patients, excluding duplication, was 3,762,332.

Conclusion

The prevalence of T1DM over the course of the study was approximately 0.017% to 0.021% of the entire population of Korea, and the annual incidence of T1DM was 3.28:100,000 overall and 3.25:100,000 for Koreans under 20 years old.

Citations

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  • Distinct changes to pancreatic volume rather than pancreatic autoantibody positivity: insights into immune checkpoint inhibitors induced diabetes mellitus
    Hung-Hui Wei, Ying-Chieh Lai, Gigin Lin, Cheng-Wei Lin, Ya-Chu Chang, John Wen-Cheng Chang, Miaw-Jene Liou, I-Wen Chen
    Diabetology & Metabolic Syndrome.2024;[Epub]     CrossRef
  • Glycemic status, insulin resistance, and mortality from lung cancer among individuals with and without diabetes
    In Young Cho, Yoosoo Chang, Eunju Sung, Boyoung Park, Jae-Heon Kang, Hocheol Shin, Sarah H. Wild, Christopher D. Byrne, Seungho Ryu
    Cancer & Metabolism.2024;[Epub]     CrossRef
  • Identification of genetic variants associated with diabetic kidney disease in multiple Korean cohorts via a genome-wide association study mega-analysis
    Heejin Jin, Ye An Kim, Young Lee, Seung-hyun Kwon, Ah Ra Do, Sujin Seo, Sungho Won, Je Hyun Seo
    BMC Medicine.2023;[Epub]     CrossRef
  • Influenza vaccination trend and related factors among patients with diabetes in Korea: Analysis using a nationwide database
    Dong-Hwa Lee, Bumhee Yang, Seonhye Gu, Eung-Gook Kim, Youlim Kim, Hyung Koo Kang, Yeong Hun Choe, Hyun Jeong Jeon, Seungyong Park, Hyun Lee
    Frontiers in Endocrinology.2023;[Epub]     CrossRef
  • Insulin Fact Sheet in Type 1 and 2 Diabetes Mellitus and Trends of Antidiabetic Medication Use in Insulin Users with Type 2 Diabetes Mellitus: 2002 to 2019
    Jiyun Park, Gyuri Kim, Bong-Sung Kim, Kyung-Do Han, So Yoon Kwon, So Hee Park, You-Bin Lee, Sang-Man Jin, Jae Hyeon Kim
    Diabetes & Metabolism Journal.2023; 47(2): 211.     CrossRef
  • Association of Body Mass Index and Fracture Risk Varied by Affected Bones in Patients with Diabetes: A Nationwide Cohort Study
    Se-Won Lee, Kyungdo Han, Hyuk-Sang Kwon
    Diabetes & Metabolism Journal.2023; 47(2): 242.     CrossRef
  • Association between long-term air pollution exposure and development of diabetes among community-dwelling adults: Modification of the associations by dietary nutrients
    Moon-Kyung Shin, Kyoung-Nam Kim
    Environment International.2023; 174: 107908.     CrossRef
  • Structural studies and cell proliferation activity of human Follistatin-like 1 in reducing and non-reducing conditions
    S. Shahrbanoo Jafari, Rahman Emamzadeh, Mahboobeh Nazari, Mohamad Reza Ganjalikhany
    Process Biochemistry.2023; 130: 245.     CrossRef
  • Exercise Frequency Reduction Is Associated With Higher Risk of Infection in Newly Diagnosed Diabetes: A Nationally Representative Cohort Study
    Yohwan Lim, Hye Jun Kim, Sung Soo Yoon, Sang Jun Lee, Myeong Hoon Lee, Hyewon Park, Sun Jae Park, Seogsong Jeong, Hyun Wook Han
    Journal of Korean Medical Science.2023;[Epub]     CrossRef
  • Impact of statin treatment on cardiovascular risk in patients with type 1 diabetes: a population-based cohort study
    Joonsang Yoo, Jimin Jeon, Minyoul Baek, Sun Ok Song, Jinkwon Kim
    Journal of Translational Medicine.2023;[Epub]     CrossRef
  • Prevalence and clinical characteristics of fulminant type 1 diabetes mellitus in Korean adults: A multi‐institutional joint research
    Sun Ok Song, Jae‐Seung Yun, Seung‐Hyun Ko, Yu‐Bae Ahn, Bo‐Yeon Kim, Chul‐Hee Kim, Ja Young Jeon, Dae Jung Kim, Da Hae Seo, So Hun Kim, Jung Hyun Noh, Da Young Lee, Kyung‐Soo Kim, Soo‐Kyung Kim
    Journal of Diabetes Investigation.2022; 13(1): 47.     CrossRef
  • Epidemiology and phenotypes of diabetes in children and adolescents in non-European-origin populations in or from Western Pacific region
    Steven James, Jayanthi Maniam, Pik-To Cheung, Tatsuhiko Urakami, Julia von Oettingen, Supawadee Likitmaskul, Graham Ogle
    World Journal of Clinical Pediatrics.2022; 11(2): 173.     CrossRef
  • Weight change and the risk of hip fractures in patients with type 2 diabetes: a nationwide cohort study
    S.-W. Lee, K. Han, H.-S. Kwon
    Osteoporosis International.2022; 33(8): 1755.     CrossRef
  • Phytochemicals of mustard (Brassica Campestris) leaves tuned the nickel‐cobalt bimetallic oxide properties for enzyme‐free sensing of glucose
    Abdul Ghaffar Solangi, Tajness Pirzada, Aqeel Ahmed Shah, Imran Ali Halepoto, Abdul Sattar Chang, Zulifqar Ali Solangi, Muhammad Yameen Solangi, Umair Aftab, Matteo Tonezzer, Aneela Tahira, Ayman Nafady, Shymaa S. Medany, Zafar Hussain Ibupoto
    Journal of the Chinese Chemical Society.2022; 69(9): 1608.     CrossRef
  • Low relative hand grip strength is associated with a higher risk for diabetes and impaired fasting glucose among the Korean population
    Min Jin Lee, Ah Reum Khang, Dongwon Yi, Yang Ho Kang, Giacomo Pucci
    PLOS ONE.2022; 17(10): e0275746.     CrossRef
  • Incidence and risk factors of diabetes mellitus in the Chinese population: a dynamic cohort study
    Long Xue, Huiying Wang, YunZhen He, Mengyun Sui, Hongzheng Li, Lin Mei, Xiaohua Ying
    BMJ Open.2022; 12(11): e060730.     CrossRef
  • Illness Experiences of Adolescents with Type 1 Diabetes
    Ji Eun Kim, Ilaria Campesi
    Journal of Diabetes Research.2022; 2022: 1.     CrossRef
  • Association between secondhand smoke exposure and diabetes mellitus in 131 724 Korean never smokers using self‐reported questionnaires and cotinine levels: Gender differences
    Byung Jin Kim, Ji Hye Kim, Jeong Gyu Kang, Bum Soo Kim, Jin Ho Kang
    Journal of Diabetes.2021; 13(1): 43.     CrossRef
  • The risk of hip fractures in individuals over 50 years old with prediabetes and type 2 diabetes – A longitudinal nationwide population-based study
    Ho Youn Park, Kyoungdo Han, Youngwoo Kim, Yoon Hwan Kim, Yoo Joon Sur
    Bone.2021; 142: 115691.     CrossRef
  • Electrochemical performance of the spinel NiCo2O4 based nanostructure synthesized by chemical bath method for glucose detection
    Kyu-bong Jang, Kyoung Ryeol Park, Kang Min Kim, Soong-keun Hyun, Chisung Ahn, Jong Cheol Kim, Sung-chul Lim, HyukSu Han, Sungwook Mhin
    Applied Surface Science.2021; 545: 148927.     CrossRef
  • Risk Factors of Undiagnosed Diabetes Mellitus among Korean Adults: A National Cross-Sectional Study Using the KNHANES Data
    Sangwon Lee, Kwang Sun Ryu, Ha Ye Jin Kang, Na Young You, Kui Son Choi, Yul Hwangbo, Jae Wook Lee, Hyo Soung Cha
    International Journal of Environmental Research and Public Health.2021; 18(3): 1195.     CrossRef
  • Increased Incidence of Pediatric Diabetic Ketoacidosis After COVID-19: A Two-Center Retrospective Study in Korea
    Min Jeong Han, Jun Ho Heo
    Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2021; Volume 14: 783.     CrossRef
  • Trends of Diabetes and Prediabetes Prevalence among Korean Adolescents From 2007 to 2018
    Ji Hyun Kim, Jung Sub Lim
    Journal of Korean Medical Science.2021;[Epub]     CrossRef
  • Association between domain-specific physical activity and diabetes in Korean adults
    Eun-Byeol Lee, Sunghyun Hong, Jihee Min, Dong-Hyuk Park, Wonhee Cho, Sang-Hoon Suh, Hae-Dong Lee, Han-Joo Lee, Heejin Kimm, Sun Ha Jee, Eun Seok Kang, Dong Hoon Lee, Justin Y. Jeon
    Scientific Reports.2021;[Epub]     CrossRef
  • Prestroke Glucose Control and Functional Outcome in Patients With Acute Large Vessel Occlusive Stroke and Diabetes After Thrombectomy
    Jun Young Chang, Wook-Joo Kim, Ji Hyun Kwon, Beom Joon Kim, Joon-Tae Kim, Jun Lee, Jae Kwan Cha, Dae-Hyun Kim, Yong-Jin Cho, Keun-Sik Hong, Soo Joo Lee, Jong-Moo Park, Byung-Chul Lee, Mi Sun Oh, Sang-Hwa Lee, Chulho Kim, Dong-Eog Kim, Kyung Bok Lee, Tae H
    Diabetes Care.2021; 44(9): 2140.     CrossRef
  • Diabetes diagnosis from administrative claims and estimation of the true prevalence of diabetes among 4.2 million individuals of the Veneto region (North East Italy)
    Enrico Longato, Barbara Di Camillo, Giovanni Sparacino, Claudio Saccavini, Angelo Avogaro, Gian Paolo Fadini
    Nutrition, Metabolism and Cardiovascular Diseases.2020; 30(1): 84.     CrossRef
  • The Combined Impact of Chronic Kidney Disease and Diabetes on the Risk of Colorectal Cancer Depends on Sex: A Nationwide Population-Based Study
    Hyung Jung Oh, Hye Ah Lee, Chang Mo Moon, Dong-Ryeol Ryu
    Yonsei Medical Journal.2020; 61(6): 506.     CrossRef
  • Does Diabetes Increase the Risk of Contracting COVID-19? A Population-Based Study in Korea
    Sung-Youn Chun, Dong Wook Kim, Sang Ah Lee, Su Jung Lee, Jung Hyun Chang, Yoon Jung Choi, Seong Woo Kim, Sun Ok Song
    Diabetes & Metabolism Journal.2020; 44(6): 897.     CrossRef
  • Synthesis of NiCo2O4 Nanostructures and Their Electrochemial Properties for Glucose Detection
    Kyu-bong Jang, Kyoung Ryeol Park, Kang Min Kim, Soong-keun Hyun, Jae-eun Jeon, Young Sik Song, Soo-keun Park, Kyoung-il Moon, Chisung Ahn, Sung-chul Lim, Jaewoong Lee, Jong Cheol Kim, HyukSu Han, Sungwook Mhin
    Nanomaterials.2020; 11(1): 55.     CrossRef
  • Clinical Outcomes of COVID-19 Patients with Type 2 Diabetes: A Population-Based Study in Korea
    Ji Hong You, Sang Ah Lee, Sung-Youn Chun, Sun Ok Song, Byung-Wan Lee, Dae Jung Kim, Edward J. Boyko
    Endocrinology and Metabolism.2020; 35(4): 901.     CrossRef
  • Trends in Hyperglycemic Crisis Hospitalizations and in- and out-of-Hospital Mortality in the Last Decade Based on Korean National Health Insurance Claims Data
    Ji Hong You, Sun Ok Song, Se Hee Park, Kyoung Hye Park, Joo Young Nam, Dong Wook Kim, Hyun Min Kim, Dong-Jun Kim, Yong-ho Lee, Byung-Wan Lee
    Endocrinology and Metabolism.2019; 34(3): 275.     CrossRef
  • Longitudinal changes in left ventricular structure and function in patients with type 2 diabetes: Normal weight versus overweight/obesity
    Seong Hwan Kim, Ki-Chul Sung, Seung Ku Lee, Juri Park, Nan Hee Kim, Sun H Kim, Chol Shin
    Diabetes and Vascular Disease Research.2019; 16(5): 450.     CrossRef
  • High Proportion of Adult Cases and Prevalence of Metabolic Syndrome in Type 1 Diabetes Mellitus Population in Korea: A Nationwide Study
    You-Bin Lee, Kyungdo Han, Bongsung Kim, Sang-Man Jin, Seung-Eun Lee, Ji Eun Jun, Jiyeon Ahn, Gyuri Kim, Jae Hyeon Kim
    Diabetes & Metabolism Journal.2019; 43(1): 76.     CrossRef
  • Diabetes and the Risk of Infection: A National Cohort Study
    Eun Jin Kim, Kyoung Hwa Ha, Dae Jung Kim, Young Hwa Choi
    Diabetes & Metabolism Journal.2019; 43(6): 804.     CrossRef
  • Clinical characteristics of diabetic ketoacidosis in users and non-users of SGLT2 inhibitors
    J.Y. Jeon, S.-K. Kim, K.-S. Kim, S.O. Song, J.-S. Yun, B.-Y. Kim, C.-H. Kim, S.O. Park, S. Hong, D.H. Seo, J.A. Seo, J.H. Noh, D.J. Kim
    Diabetes & Metabolism.2019; 45(5): 453.     CrossRef
  • Trends in incidence of total or type 2 diabetes: systematic review
    Dianna J Magliano, Rakibul M Islam, Elizabeth L M Barr, Edward W Gregg, Meda E Pavkov, Jessica L Harding, Maryam Tabesh, Digsu N Koye, Jonathan E Shaw
    BMJ.2019; : l5003.     CrossRef
  • HDL-Cholesterol, Its Variability, and the Risk of Diabetes: A Nationwide Population-Based Study
    Seung-Hwan Lee, Hun-Sung Kim, Yong-Moon Park, Hyuk-Sang Kwon, Kun-Ho Yoon, Kyungdo Han, Mee Kyoung Kim
    The Journal of Clinical Endocrinology & Metabolism.2019; 104(11): 5633.     CrossRef
  • Elevated N -acetyl-β- d -glucosaminidase, a urinary tubular damage marker, is a significant predictor of carotid artery atherosclerosis in type 1 diabetes, independent of albuminuria: A cross-sectional study
    Minyoung Lee, Namki Hong, Yong-ho Lee, Eun Seok Kang, Bong Soo Cha, Byung-Wan Lee
    Journal of Diabetes and its Complications.2018; 32(8): 777.     CrossRef
  • House dust mite and Cockroach specific Immunoglobulin E sensitization is associated with diabetes mellitus in the adult Korean population
    Mee Kyoung Kim, Jee Sun Jeong, Kyungdo Han, Ki Hyun Baek, Ki-Ho Song, Hyuk-Sang Kwon
    Scientific Reports.2018;[Epub]     CrossRef
  • Mortality and causes of death in patients with atrial fibrillation: A nationwide population-based study
    Euijae Lee, Eue-Keun Choi, Kyung-Do Han, HyunJung Lee, Won-Seok Choe, So-Ryoung Lee, Myung-Jin Cha, Woo-Hyun Lim, Yong-Jin Kim, Seil Oh, Giuseppina Novo
    PLOS ONE.2018; 13(12): e0209687.     CrossRef
  • Factors associated with greater benefit of a national reimbursement policy for blood glucose test strips in adult patients with type 1 diabetes: A prospective cohort study
    Sang‐Man Jin, Jong Ha Baek, Sunghwan Suh, Chang Hee Jung, Woo Je Lee, Cheol‐Young Park, Hae Kyung Yang, Jae Hyoung Cho, Byung‐Wan Lee, Jae Hyeon Kim
    Journal of Diabetes Investigation.2018; 9(3): 549.     CrossRef
  • Association of blood pressure components with mortality and cardiovascular events in prehypertensive individuals: a nationwide population-based cohort study
    Hyung Jung Oh, Seulbi Lee, Eun-Kyung Lee, Oesook Lee, Eunhee Ha, Eun-Mi Park, Seung-Jung Kim, Duk-Hee Kang, Kyu Bok Choi, Seung Jun Kim, Dong-Ryeol Ryu
    Annals of Medicine.2018; 50(5): 443.     CrossRef
  • Development and Validation of the Korean Diabetes Risk Score: A 10-Year National Cohort Study
    Kyoung Hwa Ha, Yong-ho Lee, Sun Ok Song, Jae-woo Lee, Dong Wook Kim, Kyung-hee Cho, Dae Jung Kim
    Diabetes & Metabolism Journal.2018; 42(5): 402.     CrossRef
  • Clinical Utility and Cross-Reactivity of Insulin and C-Peptide Assays by the Lumipulse G1200 System
    Jongwon Oh, Jae Hyeon Kim, Hyung-Doo Park
    Annals of Laboratory Medicine.2018; 38(6): 530.     CrossRef
  • The optimal cut-off of blood pressure related to left ventricular diastolic dysfunction and remodeling in Asian diabetic patients
    Ju Young Jung, Sung Keun Park, Jae-Hong Ryoo, Chang-Mo Oh, Jeong Gyu Kang, Kanghee Moon, Keum Ok Lee, Joong-Myung Choi
    Journal of Cardiology.2018; 71(1): 16.     CrossRef
  • Association of Body Mass Index with Risk of Major Adverse Cardiovascular Events and Mortality in People with Diabetes
    Dong Hun Lee, Kyoung Hwa Ha, Hyeon Chang Kim, Dae Jung Kim
    Journal of Obesity & Metabolic Syndrome.2018; 27(1): 61.     CrossRef
  • Obesity and Metabolic Unhealthiness Have Different Effects on Colorectal Neoplasms
    Sun-Hye Ko, Myong Ki Baeg, Seung Yeon Ko, Hee Sun Jung, Pumsoo Kim, Myung-Gyu Choi
    The Journal of Clinical Endocrinology & Metabolism.2017; 102(8): 2762.     CrossRef
  • Alteration of oxidative stress and inflammatory cytokines induces apoptosis in diabetic nephropathy
    Jibin Sha, Bo Sui, Xiaoqing Su, Qingfang Meng, Chenggang Zhang
    Molecular Medicine Reports.2017; 16(5): 7715.     CrossRef
  • BMI and All-Cause Mortality in Normoglycemia, Impaired Fasting Glucose, Newly Diagnosed Diabetes, and Prevalent Diabetes: A Cohort Study
    Eun Young Lee, Yong-ho Lee, Sang-Wook Yi, Soon-Ae Shin, Jee-Jeon Yi
    Diabetes Care.2017; 40(8): 1026.     CrossRef
  • Fasting glucose and risk of colorectal cancer in the Korean Multi-center Cancer Cohort
    Hyeree Park, Sooyoung Cho, Hyeongtaek Woo, Sue K. Park, Hai-Rim Shin, Soung-Hoon Chang, Keun-Young Yoo, Aesun Shin, Cheng Hu
    PLOS ONE.2017; 12(11): e0188465.     CrossRef
  • Differential association of body mass index on glycemic control in type 1 diabetes
    Eun Young Lee, Yong‐ho Lee, Sang‐Man Jin, Hae Kyung Yang, Chang Hee Jung, Cheol‐Young Park, Jae Hyoung Cho, Woo Je Lee, Byung‐Wan Lee, Jae Hyeon Kim
    Diabetes/Metabolism Research and Reviews.2017;[Epub]     CrossRef
  • Stepwise Approach to Problematic Hypoglycemia in Korea: Educational, Technological, and Transplant Interventions
    Sang-Man Jin
    Endocrinology and Metabolism.2017; 32(2): 190.     CrossRef
  • Mortality and causes of death in a national sample of type 2 diabetic patients in Korea from 2002 to 2013
    Yu Mi Kang, Ye-Jee Kim, Joong-Yeol Park, Woo Je Lee, Chang Hee Jung
    Cardiovascular Diabetology.2016;[Epub]     CrossRef
Pathophysiology
Protective Effects of Ginger (Zingiber officinale) Extract against Diabetes-Induced Heart Abnormality in Rats
Behrouz Ilkhanizadeh, Alireza Shirpoor, Mohamad hasan Khadem Ansari, Samira Nemati, Yusef Rasmi
Diabetes Metab J. 2016;40(1):46-53.   Published online February 19, 2016
DOI: https://doi.org/10.4093/dmj.2016.40.1.46
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AbstractAbstract PDFPubReader   
Background

Diabetic cardiomyopathy is an important causal factor in morbidity and mortality among diabetic patients, and currently, no effective means are available to reverse its pathological progress. The purpose of the present study was to investigate the effect of ginger extract on apolipoproteins (apo) A and B, hyperhomocysteinemia, cathepsin G and leptin changes, as well as cardiac fibrosis and heart muscle cell proliferation under hyperglycemic conditions in vivo.

Methods

Twenty-four male Wistar rats were divided into three groups, namely: control, non-treated diabetic, and ginger extract-treated diabetic groups. The ginger extract-treated diabetic group received a 50 mg daily dose of ginger extract intragastrically for 6 weeks.

Results

The results revealed concurrent significant increases in plasma C-reactive protein (CRP), homocysteine (Hcy), cathepsin G and apoB levels and decreases in apoA and leptin levels in the non-treated diabetic group compared to the control group. Moreover, heart structural changes, including fibrosis and heart muscle cell proliferation, were observed in non-treated diabetic rats compared to the control rats. Significant amelioration of changes in the heart structure together with restoration of the elevated levels of Hcy and CRP, leptin, cathepsin G, and apoA and B were found in the ginger extract-treated diabetic group compared to the non-treated diabetic group.

Conclusion

The findings indicated that ginger extract significantly reduces heart structural abnormalities in diabetic rats and that these effects might be associated with improvements in serum apo, leptin, cathepsin G, and Hcy levels and with the antioxidant properties of ginger extract.

Citations

Citations to this article as recorded by  
  • Cardioprotective Activities of some Indian Spices: An Insight into Pharmacology and Phytochemical Investigation
    Kalyani Pathak, Manash Pratim Pathak, Riya Saikia, Urvashee Gogoi, Jon Jyoti Sahariah, Aparoop Das, Mohammad Zaki Ahmad, Tirna Paul, Jyotirmoy Das, Saif Aboud M. Alqahtani
    Current Traditional Medicine.2024;[Epub]     CrossRef
  • Network-pharmacology-based research on protective effects and underlying mechanism of Shuxin decoction against myocardial ischemia/reperfusion injury with diabetes
    Ling Yang, Yang Jian, Zai-Yuan Zhang, Bao-Wen Qi, Yu-Bo Li, Pan Long, Yao Yang, Xue Wang, Shuo Huang, Jing Huang, Long-Fu Zhou, Jie Ma, Chang-Qing Jiang, Yong-He Hu, Wen-Jing Xiao
    World Journal of Diabetes.2023; 14(7): 1057.     CrossRef
  • Evaluating the effect of Ginger Powder on Bilirubin, Creatinine, Urea and Uric Acid on Experimental Diabetic Wistar Rats in Randomized Control Trial
    Maryam Maqsood, Saima Naaz, Huma Bader Ul Ain, Zunaira Mushtaq, Makia Nasir, Aiza Qamar
    Pakistan BioMedical Journal.2022; 5(1): 351.     CrossRef
  • The effect of red ginger bread consumption on the physiological parameters of healthy subjects
    Titin Sulastri, Marleen Sunyoto, Marvel Reuben Suwitono, Jutti Levita
    Journal Of Advanced Pharmacy Education And Research.2022; 12(3): 28.     CrossRef
  • Protective effects of medicinal plant against diabetes induced cardiac disorder: A review
    Sadegh Shabab, Zahra Gholamnezhad, Maryam Mahmoudabady
    Journal of Ethnopharmacology.2021; 265: 113328.     CrossRef
  • Ginger (Zingiber Officinale Roscoe) Extract Protects the Heart Against Inflammation and Fibrosis in Diabetic Rats
    Tara Abdi, Maryam Mahmoudabady, Hadi Zare Marzouni, Saeed Niazmand, Majid Khazaei
    Canadian Journal of Diabetes.2021; 45(3): 220.     CrossRef
  • Combined ginger and garlic extract improves serum lipid profile, oxidative stress markers and reduced IL-6 in diet induced obese rats
    Peter Ifeoluwa Adegbola, Olumide Samuel Fadahunsi, Bamidele Stephen Ajilore, Adebola Olayemi Akintola, Olubukola Sinbad Olorunnisola
    Obesity Medicine.2021; 23: 100336.     CrossRef
  • The Effects of Medicinal Plants and Bioactive Natural Compounds on Homocysteine
    Mohammad Amin Atazadegan, Mohammad Bagherniya, Gholamreza Askari, Aida Tasbandi, Amirhossein Sahebkar
    Molecules.2021; 26(11): 3081.     CrossRef
  • Long-chain noncoding RNA-GAS5/hsa-miR-138-5p attenuates high glucose-induced cardiomyocyte damage by targeting CYP11B2
    Xiaozhen Zhuo, Kai Bai, Yingxian Wang, Peining Liu, Wen Xi, Jianqing She, Junhui Liu
    Bioscience Reports.2021;[Epub]     CrossRef
  • Regulation of Apolipoprotein B by Natural Products and Nutraceuticals: A Comprehensive Review
    Mohammad Bagherniya, Thomas P. Johnston, Amirhossein Sahebkar
    Current Medicinal Chemistry.2021; 28(7): 1363.     CrossRef
  • Ameliorative effects of Hydrolea zeylanica in streptozotocin-induced oxidative stress and metabolic changes in diabetic rats
    Sandeep Kumar Swain, Umesh Chandra Dash, Satish Kanhar, Atish Kumar Sahoo
    Journal of Ethnopharmacology.2020; 247: 112257.     CrossRef
  • The effect of 8 weeks of high-intensity interval training and moderate-intensity continuous training on cardiac angiogenesis factor in diabetic male rats
    Faramarz Yazdani, Fereshteh Shahidi, Pouran Karimi
    Journal of Physiology and Biochemistry.2020; 76(2): 291.     CrossRef
  • DNA methyltransferase-1 inactivation of androgen receptor axis triggers homocysteine induced cardiac fibroblast autophagy in diabetic cardiac fibrosis
    Hui Tao, Peng Shi, Hai-Yang Xuan, Xuan-Sheng Ding
    Archives of Biochemistry and Biophysics.2020; 692: 108521.     CrossRef
  • Ameliorative and protective effects of ginger and its main constituents against natural, chemical and radiation-induced toxicities: A comprehensive review
    Muhammad A. Alsherbiny, Wessam H. Abd-Elsalam, Shymaa A. El badawy, Ehab Taher, Mohamed Fares, Allan Torres, Dennis Chang, Chun Guang Li
    Food and Chemical Toxicology.2019; 123: 72.     CrossRef
  • SELECTION OF A FILLER FOR TABLETS MANUFACTURED WITH DIRECT COMPRESSION METHOD CONTAINING DRY GINGER EXTRACT
    Оlena Ruban, Malek Alkhalaf, Nataliia Gerbina
    EUREKA: Health Sciences.2019; 3: 26.     CrossRef
  • Role of medicinal plants in the management of diabetes mellitus: a review
    Bindu Jacob, Narendhirakannan R.T.
    3 Biotech.2019;[Epub]     CrossRef
  • Ginger (Zingiber officinale Roscoe) in the Prevention of Ageing and Degenerative Diseases: Review of Current Evidence
    Nur Fatin Nabilah Mohd Sahardi, Suzana Makpol
    Evidence-Based Complementary and Alternative Medicine.2019; 2019: 1.     CrossRef
  • Roles of Spicy Foods and Their Bioactive Compounds in Management of Hypercholesterolemia
    Yimin Zhao, Zhen-Yu Chen
    Journal of Agricultural and Food Chemistry.2018; 66(33): 8662.     CrossRef
  • Relaxant and vasoprotective effects of ginger extracts on porcine coronary arteries
    Hsing‑Chen Wu, Chi‑Ting Horng, Shih‑Chang Tsai, You‑Li Lee, Shou‑Cheng Hsu, Yi‑Jen Tsai, Fuu‑Jen Tsai, Jo‑Hua Chiang, Daih‑Huang Kuo, Jai‑Sing Yang
    International Journal of Molecular Medicine.2018;[Epub]     CrossRef
  • Increased hepatic FAT/CD36, PTP1B and decreased HNF4A expression contributes to dyslipidemia associated with ethanol–induced liver dysfunction: Rescue effect of ginger extract
    Alireza Shirpoor, Elaheh Heshmati, Fatemeh Kheradmand, Farzaneh Hosseini Gharalari, Leila Chodari, Roya Naderi, Farideh Nezami Majd, Mahrokh Samadi
    Biomedicine & Pharmacotherapy.2018; 105: 144.     CrossRef
  • Ginger extract mitigates ethanol-induced changes of alpha and beta – myosin heavy chain isoforms gene expression and oxidative stress in the heart of male wistar rats
    Alireza Shirpoor, Mitra Zerehpoosh, Mohammad Hasan Khadem Ansari, Fatemeh Kheradmand, Yousef Rasmi
    DNA Repair.2017; 57: 45.     CrossRef
  • Single, repeated dose toxicity and genotoxicity assessment of herb formula KIOM2012H
    Hwayong Park, Youn-Hwan Hwang, Jin Yeul Ma
    Integrative Medicine Research.2017; 6(4): 361.     CrossRef
  • Rescue effects of ginger extract on dose dependent radiation-induced histological and biochemical changes in the kidneys of male Wistar rats
    Hassan Saberi, Behnaz Keshavarzi, Alireza Shirpoor, Farzaneh Hosseini Gharalari, Yousef Rasmi
    Biomedicine & Pharmacotherapy.2017; 94: 569.     CrossRef
  • Promising Antidiabetic Drugs, Medicinal Plants and Herbs: An Update
    Mohd Iqbal Yatoo, Archana Saxena, Arumugam Gopalakris, Mahmoud Alagawany, Kuldeep Dhama
    International Journal of Pharmacology.2017; 13(7): 732.     CrossRef
  • Cardioprotective effects of rutin via alteration in TNF-α, CRP, and BNP levels coupled with antioxidant effect in STZ-induced diabetic rats
    Ravi Saklani, Suresh Kumar Gupta, Ipseeta Ray Mohanty, Binit Kumar, Sushma Srivastava, Rajani Mathur
    Molecular and Cellular Biochemistry.2016; 420(1-2): 65.     CrossRef
Obesity and Metabolic Syndrome
Increased Risk of Progression of Coronary Artery Calcification in Male Subjects with High Baseline Waist-to-Height Ratio: The Kangbuk Samsung Health Study
Hyung-Geun Oh, Shriram Nallamshetty, Eun-Jung Rhee
Diabetes Metab J. 2016;40(1):54-61.   Published online February 19, 2016
DOI: https://doi.org/10.4093/dmj.2016.40.1.54
  • 3,779 View
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  • 10 Web of Science
  • 12 Crossref
AbstractAbstract PDFPubReader   
Background

The waist-to-height ratio (WHtR) is an easy and inexpensive adiposity index that reflects central obesity. In this study, we examined the association of baseline WHtR and progression of coronary artery calcification (CAC) over 4 years of follow-up in apparently healthy Korean men.

Methods

A total of 1,048 male participants (mean age, 40.9 years) in a health-screening program in Kangbuk Samsung Hospital, Seoul, Korea who repeated a medical check-up in 2010 and 2014 were recruited. Baseline WHtR was calculated using the value for the waist in 2010 divided by the value for height in 2010. The CAC score (CACS) of each subject was measured by multi-detector computed tomography in both 2010 and 2014. Progression of CAC was defined as a CACS change over 4 years greater than 0.

Results

During the follow-up period, progression of CAC occurred in 278 subjects (26.5%). The subjects with CAC progression had slightly higher but significant baseline WHtR compared to those who did not show CAC progression (0.51±0.04 vs. 0.50±0.04, P<0.01). The proportion of subjects with CAC progression significantly increased as the baseline WHtR increased from the 1st quartile to 4th quartile groups (18.3%, 18.7%, 28.8%, and 34.2%; P<0.01). The risk for CAC progression was elevated with an odds ratio of 1.602 in the 4th quartile group of baseline WHtR even after adjustment for confounding variables (95% confidence interval, 1.040 to 2.466).

Conclusion

Increased baseline WHtR was associated with increased risk for CAC progression. WHtR might be a useful screening tool to identify individuals at high risk for subclinical atherosclerosis.

Citations

Citations to this article as recorded by  
  • Nicotine dependence and visceral adiposity as risk factors for the development and severity of carotid artery stenosis
    Mahmood Shaker Khazaal, Farqad Bader Hamdan, Qasim Sharhan Al-Mayah
    Journal of Medicine and Life.2023; 16(3): 463.     CrossRef
  • Differences in the number of stented coronary arteries based on the seven traditional obesity parameters among patients with coronary artery diseases undergoing cardiac catheterization
    Audai A Hayajneh, Islam M Alhusban, Mohammad Rababa, Sami Al-Rawashdeh, Shatha Al-Sabbah, Dania Bani-Hamad
    Electronic Journal of General Medicine.2022; 19(5): em391.     CrossRef
  • Predictive Model for High Coronary Artery Calcium Score in Young Patients with Non-Dialysis Chronic Kidney Disease
    Tae Ryom Oh, Su Hyun Song, Hong Sang Choi, Sang Heon Suh, Chang Seong Kim, Ji Yong Jung, Kyu Hun Choi, Kook-Hwan Oh, Seong Kwon Ma, Eun Hui Bae, Soo Wan Kim
    Journal of Personalized Medicine.2021; 11(12): 1372.     CrossRef
  • Computed tomography calcium scoring association and reclassification of clinical cardiovascular risk in asymptomatic Mexican patients
    Aldo Javier Vázquez Mézquita, Michelle Claire Williams, Rafael Choza Chenhalls, Nancy Berenice Guzmán Martínez, Ana Patricia Chischistz Condey, Maria José Acosta Falomir, Marco Antonio Téliz Meneses, María Nayeli Vázquez Sánchez
    SAGE Open Medicine.2020; 8: 205031212093823.     CrossRef
  • The association of waist-to-height ratio and other anthropometric measurements with subclinical atherosclerosis: Results from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)
    Rosana Raele, Paulo A. Lotufo, Marcio S. Bittencourt, Maria de Jesus M. Fonseca, Alessandra C. Goulart, Itamar S. Santos, Isabela M. Bensenor
    Nutrition, Metabolism and Cardiovascular Diseases.2020; 30(11): 1989.     CrossRef
  • The Risk of Myocardial Infarction and Ischemic Stroke According to Waist Circumference in 21,749,261 Korean Adults: A Nationwide Population-Based Study
    Jung-Hwan Cho, Eun-Jung Rhee, Se-Eun Park, Hyemi Kwon, Jin-Hyung Jung, Kyung-Do Han, Yong-Gyu Park, Hye Soon Park, Yang-Hyun Kim, Soon-Jib Yoo, Won-Young Lee
    Diabetes & Metabolism Journal.2019; 43(2): 206.     CrossRef
  • Being Metabolically Healthy, the Most Responsible Factor for Vascular Health
    Eun-Jung Rhee
    Diabetes & Metabolism Journal.2018; 42(1): 19.     CrossRef
  • The renal tubular damage marker urinary N-acetyl-β-d-glucosaminidase may be more closely associated with early detection of atherosclerosis than the glomerular damage marker albuminuria in patients with type 2 diabetes
    So Ra Kim, Yong-ho Lee, Sang-Guk Lee, Eun Seok Kang, Bong-Soo Cha, Byung-Wan Lee
    Cardiovascular Diabetology.2017;[Epub]     CrossRef
  • Influencia de la actividad física y el consumo calórico sobre la adiposidad visceral en adultos de la ciudad de Cuenca, Ecuador
    Rina Ortiz, Maritza Torres, Wilson Siguencia, Nube Sigüenza-Cobos, Juan Salazar, Roberto Añez, Joselyn Rojas, Valmore Bermúdez
    Revista Argentina de Endocrinología y Metabolismo.2017; 54(4): 160.     CrossRef
  • The association between various indices of obesity and severity of atherosclerosis in adults in the north of Iran
    Arsalan Salari, Maryam Shakiba, Marjan Mahdavi-Roshan, Mahboobeh Gholipour, Moona Naghshbandi, Ramin Rajabi
    Medicine.2016; 95(50): e5670.     CrossRef
  • Diet Quality and Mortality Risk in Metabolically Obese Normal-Weight Adults
    Yong-Moon Mark Park, Teresa T. Fung, Susan E. Steck, Jiajia Zhang, Linda J. Hazlett, Kyungdo Han, Seung-Hwan Lee, Anwar T. Merchant
    Mayo Clinic Proceedings.2016; 91(10): 1372.     CrossRef
  • Waist Circumference as a Marker of Obesity Is More Predictive of Coronary Artery Calcification than Body Mass Index in Apparently Healthy Korean Adults: The Kangbuk Samsung Health Study
    Jongsin Park, Eun Seo Lee, Da Young Lee, Jihyun Kim, Se Eun Park, Cheol-Young Park, Won-Young Lee, Ki-Won Oh, Sung-Woo Park, Eun-Jung Rhee
    Endocrinology and Metabolism.2016; 31(4): 559.     CrossRef
The Association of Serum Cystatin C with Glycosylated Hemoglobin in Korean Adults
Eun Hee Sim, Hye Won Lee, Hyun Ju Choi, Dong Wook Jeong, Seok Man Son, Yang Ho Kang
Diabetes Metab J. 2016;40(1):62-69.   Published online November 27, 2015
DOI: https://doi.org/10.4093/dmj.2016.40.1.62
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AbstractAbstract PDFPubReader   
Background

Cystatin C has been known to be associated not only with early renal impairment but also with the incidence of diabetic conditions (prediabetes plus diabetes). However, it is not clear whether cystatin C levels are associated with the prevalence of diabetic conditions in Asian populations. We evaluated this association using glycosylated hemoglobin (HbA1c) levels as the definition of diabetes in Korean adults.

Methods

We analyzed data from 1,559 Korean adults (937 men and 622 women) with available serum cystatin C and HbA1c values.

Results

The serum cystatin C levels in subjects with prediabetes and diabetes were significantly increased (0.91±0.14 mg/L in prediabetes and 0.91±0.17 mg/L in diabetes vs. 0.88±0.13 mg/L in patients with normal glucose levels, P=0.001). At increasing cystatin C levels, the prevalence of subjects with prediabetes (30.2% vs. 14.6%, P<0.001) and those with diabetes (10.6% vs. 8.0%, P<0.001) significantly increased in the group with the highest cystatin C levels. The group with the highest cystatin C levels had a significantly increased odds ratio (OR) for the presence of diabetic conditions compared to the group with the lowest values in total subjects (OR, 2.35; 95% confidence interval [CI], 1.54 to 3.58; P<0.001) and in women (OR, 4.13; 95% CI, 1.97 to 8.65; P<0.001), though there was no significant increase after adjusting for multiple variables.

Conclusions

Higher levels of serum cystatin C are associated with an increased prevalence of diabetic conditions in Korean adults. Our findings may extend the positive association of cystatin C with diabetes incidence to an Asian population.

Citations

Citations to this article as recorded by  
  • Prognostic significance of serum cystatin C in acute brainstem infarctions patients
    H. Li, B. Zhang, Z. Huang, H. Wu, B. Qin, L. Zhou, Z. Lu, F. Qin
    Revue Neurologique.2024;[Epub]     CrossRef
  • Cardiovascular risk assessment in prediabetic patients in a hypertensive population: The role of cystatin C
    Rafael Garcia-Carretero, Luis Vigil-Medina, Inmaculada Mora-Jimenez, Cristina Soguero-Ruiz, Rebeca Goya-Esteban, Javier Ramos-Lopez, Oscar Barquero-Perez
    Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2018; 12(5): 625.     CrossRef
  • Characteristics of Dapagliflozin Responders: A Longitudinal, Prospective, Nationwide Dapagliflozin Surveillance Study in Korea
    Eugene Han, Ari Kim, Sung Jae Lee, Je-Yon Kim, Jae Hyeon Kim, Woo Je Lee, Byung-Wan Lee
    Diabetes Therapy.2018; 9(4): 1689.     CrossRef
  • Cystatin C as a Predictor for Diabetes according to Glycosylated Hemoglobin Levels in Korean Patients
    Eon Ju Jeon, Ji Hyun Lee
    Diabetes & Metabolism Journal.2016; 40(1): 32.     CrossRef
  • Prevalence of Reduced Kidney Function by Estimated Glomerular Filtration Rate Using an Equation Based on Creatinine and Cystatin C in Metabolic Syndrome and Its Components in Korean Adults
    Yang Ho Kang, Dong Wook Jeong, Seok Man Son
    Endocrinology and Metabolism.2016; 31(3): 446.     CrossRef
  • Letter: The Association of Serum Cystatin C with Glycosylated Hemoglobin in Korean Adults (Diabetes Metab J 2016;40:62-9)
    Kyung-Soo Kim
    Diabetes & Metabolism Journal.2016; 40(2): 171.     CrossRef
  • Response: The Association of Serum Cystatin C with Glycosylated Hemoglobin in Korean Adults (Diabetes Metab J 2016;40:62-9)
    Yang Ho Kang
    Diabetes & Metabolism Journal.2016; 40(2): 173.     CrossRef
Others
Effect of Atorvastatin on Growth Differentiation Factor-15 in Patients with Type 2 Diabetes Mellitus and Dyslipidemia
Ji Min Kim, Min Kyung Back, Hyon-Seung Yi, Kyong Hye Joung, Hyun Jin Kim, Bon Jeong Ku
Diabetes Metab J. 2016;40(1):70-78.   Published online February 19, 2016
DOI: https://doi.org/10.4093/dmj.2016.40.1.70
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AbstractAbstract PDFPubReader   
Background

Elevated serum levels of growth differentiation factor-15 (GDF-15) are associated with type 2 diabetes. Therefore, the effects of atorvastatin on metabolic parameters and GDF-15 levels in patients with type 2 diabetes and dyslipidemia were evaluated.

Methods

In this prospective randomized trial from February 2013 to March 2014, 50 consecutive type 2 diabetic patients with a low density lipoprotein cholesterol (LDL-C) levels ≥100 mg/dL were enrolled. The patients were divided into two groups based on the amount of atorvastatin prescribed, 10 mg/day (n=23) or 40 mg/day (n=27). The effect of atorvastatin on metabolic parameters, including lipid profiles and GDF-15 levels, at baseline and after 8 weeks of treatment were compared.

Results

The baseline metabolic parameters and GDF-15 levels were not significantly different between the two groups. After 8 weeks of treatment, the total cholesterol (TC) and LDL-C levels were significantly decreased in both groups. The mean changes in TC and LDL-C levels were more significant in the 40 mg atorvastatin group. The GDF-15 level was decreased in the 10 mg atorvastatin group, from 1,460.6±874.8 to 1,451.0±770.8 pg/mL, and was increased in the 40 mg atorvastatin group, from 1,271.6±801.0 to 1,341.4±855.2 pg/mL. However, the change in the GDF-15 level was not statistically significant in the 10 or 40 mg atorvastatin group (P=0.665 and P=0.745, respectively).

Conclusion

The GDF-15 levels were not significantly changed after an 8-week treatment with atorvastatin in type 2 diabetic patients.

Citations

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  • The relationship of Growth differentiation factor-15 with renal damage and dyslipidemia in non-albuminuric and albuminuric Type-2 Diabetes Mellitus
    Hasan Esat Yücel, Bilal İlanbey
    Medical Science and Discovery.2022; 9(6): 334.     CrossRef
  • Comparative effectiveness of statins on non-high density lipoprotein cholesterol in people with diabetes and at risk of cardiovascular disease: systematic review and network meta-analysis
    Alexander Hodkinson, Dialechti Tsimpida, Evangelos Kontopantelis, Martin K Rutter, Mamas A Mamas, Maria Panagioti
    BMJ.2022; : e067731.     CrossRef
  • The Cytokine Growth Differentiation Factor-15 and Skeletal Muscle Health: Portrait of an Emerging Widely Applicable Disease Biomarker
    Boel De Paepe
    International Journal of Molecular Sciences.2022; 23(21): 13180.     CrossRef
  • Biomarkers of subclinical atherosclerosis in patients with psoriasis
    Hannah Kaiser, Xing Wang, Amanda Kvist-Hansen, Martin Krakauer, Peter Michael Gørtz, Benjamin D. McCauley, Lone Skov, Christine Becker, Peter Riis Hansen
    Scientific Reports.2021;[Epub]     CrossRef
  • Growth differentiation factor-15 regulates oxLDL-induced lipid homeostasis and autophagy in human macrophages
    Kathrin Ackermann, Gabriel A. Bonaterra, Ralf Kinscherf, Anja Schwarz
    Atherosclerosis.2019; 281: 128.     CrossRef
Brief Report
Epidemiology
Data Analytic Process of a Nationwide Population-Based Study Using National Health Information Database Established by National Health Insurance Service
Yong-ho Lee, Kyungdo Han, Seung-Hyun Ko, Kyung Soo Ko, Ki-Up Lee
Diabetes Metab J. 2016;40(1):79-82.   Published online February 19, 2016
DOI: https://doi.org/10.4093/dmj.2016.40.1.79
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AbstractAbstract PDFPubReader   

In 2014, the National Health Insurance Service (NHIS) signed a memorandum of understanding with the Korean Diabetes Association to provide limited open access to its databases for investigating the past and current status of diabetes and its management. NHIS databases include the entire Korean population; therefore, it can be used as a population-based nationwide study for various diseases, including diabetes and its complications. This report presents how we established the analytic system of nation-wide population-based studies using the NHIS database as follows: the selection of database study population and its distribution and operational definition of diabetes and patients of currently ongoing collaboration projects.

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  • Repeated detection of non‐alcoholic fatty liver disease increases the incidence risk of type 2 diabetes in young adults
    Jin Hwa Kim, Young Sang Lyu, Mee Kyoung Kim, Sang Yong Kim, Ki‐Hyun Baek, Ki‐Ho Song, Kyungdo Han, Hyuk‐Sang Kwon
    Diabetes, Obesity and Metabolism.2024; 26(1): 180.     CrossRef
  • Increased risk of incident mental disorders in adults with new-onset type 1 diabetes diagnosed after the age of 19: A nationwide cohort study
    Seohyun Kim, Gyuri Kim, So Hyun Cho, Rosa Oh, Ji Yoon Kim, You-Bin Lee, Sang-Man Jin, Kyu Yeon Hur, Jae Hyeon Kim
    Diabetes & Metabolism.2024; 50(1): 101505.     CrossRef
  • Risk of dementia in survivors of active tuberculosis in Korea: A nationwide cohort study
    Yohwan Yeo, Jung Eun Yoo, Kyungdo Han, Jin-Hyung Jung, Hayoung Choi, Jongkyu Park, Dong Wook Shin, Hyun Lee
    Journal of Infection and Public Health.2024; 17(2): 286.     CrossRef
  • Cumulative exposure to hypertriglyceridemia and risk of type 2 diabetes in young adults
    Min-Kyung Lee, Kyungdo Han, Bongsung Kim, Jong-Dai Kim, Moon Jung Kim, Byungpyo Kim, Jung Heo, Jiyeon Ahn, Seo-Young Sohn, Jae-Hyuk Lee
    Diabetes Research and Clinical Practice.2024; 208: 111109.     CrossRef
  • Bipolar disorder and the risk of cardiometabolic diseases, heart failure, and all-cause mortality: a population-based matched cohort study in South Korea
    You-Bin Lee, Hyewon Kim, Jungkuk Lee, Dongwoo Kang, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim, Hong Jin Jeon, Kyu Yeon Hur
    Scientific Reports.2024;[Epub]     CrossRef
  • Psychotic Disorders and the Risk of Type 2 Diabetes Mellitus, Atherosclerotic Cardiovascular Diseases, and All-Cause Mortality: A Population-Based Matched Cohort Study
    You-Bin Lee, Hyewon Kim, Jungkuk Lee, Dongwoo Kang, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim, Hong Jin Jeon, Kyu Yeon Hur
    Diabetes & Metabolism Journal.2024; 48(1): 122.     CrossRef
  • Risk of hematologic malignant neoplasms from head CT radiation in children and adolescents presenting with minor head trauma: a nationwide population-based cohort study
    Seungjae Lee, Hae Young Kim, Kyung Hee Lee, Jungheum Cho, Choonsik Lee, Kwang Pyo Kim, Jinhee Hwang, Ji Hoon Park
    European Radiology.2024;[Epub]     CrossRef
  • Risk of Depression according to Cumulative Exposure to a Low-Household Income Status in Individuals with Type 2 Diabetes Mellitus: A Nationwide Population- Based Study
    So Hee Park, You-Bin Lee, Kyu-na Lee, Bongsung Kim, So Hyun Cho, So Yoon Kwon, Jiyun Park, Gyuri Kim, Sang-Man Jin, Kyu Yeon Hur, Kyungdo Han, Jae Hyeon Kim
    Diabetes & Metabolism Journal.2024; 48(2): 290.     CrossRef
  • The associations of herpes simplex virus and varicella zoster virus infection with dementia: a nationwide retrospective cohort study
    Eunhae Shin, Sang Ah Chi, Tae-Young Chung, Hee Jin Kim, Kyunga Kim, Dong Hui Lim
    Alzheimer's Research & Therapy.2024;[Epub]     CrossRef
  • Mid- and long-term risk of atrial fibrillation among breast cancer surgery survivors
    Yong-Moon Mark Park, Wonyoung Jung, Yohwan Yeo, Sang Hyun Park, Michael G. Fradley, Sindhu J. Malapati, Tushar Tarun, Vinay Raj, Hong Seok Lee, Tasneem Z. Naqvi, Ronda S. Henry-Tillman, Jawahar L. Mehta, Mario Schootman, Benjamin C. Amick, Kyungdo Han, Do
    BMC Medicine.2024;[Epub]     CrossRef
  • Metabolic dysfunction-associated steatotic liver disease and risk of esophageal cancer in patients with diabetes mellitus: a nationwide cohort study
    Yeong Jeong Jeon, Kyungdo Han, Seung Woo Lee, Ji Eun Lee, Junhee Park, In Young Cho, Jong Ho Cho, Dong Wook Shin
    Diseases of the Esophagus.2024;[Epub]     CrossRef
  • Changes in physical activity and diabetes risk after cancer diagnosis: a nationwide cohort study
    Wonyoung Jung, In Young Cho, Jinhyung Jung, Mi Hee Cho, Hye Yeon Koo, Yong-Moon Mark Park, Jong-Ha Baek, Kyungdo Han, Dong Wook Shin
    Journal of Cancer Survivorship.2024;[Epub]     CrossRef
  • Income variability and incident cardiovascular disease in diabetes: a population-based cohort study
    Yong-Moon Mark Park, Jong-Ha Baek, Hong Seok Lee, Tali Elfassy, Clare C Brown, Mario Schootman, Marie-Rachelle Narcisse, Seung-Hyun Ko, Pearl A McElfish, Michael R Thomsen, Benjamin C Amick, Seong-Su Lee, Kyungdo Han
    European Heart Journal.2024; 45(21): 1920.     CrossRef
  • Association between physical activity changes and risk of incident ischemic stroke following cancer diagnosis: A nationwide retrospective cohort study
    Wonyoung Jung, In Young Cho, Jinhyung Jung, Mi Hee Cho, Hye Yeon Koo, Yong‐Moon Mark Park, Be‐Long Cho, Hyuktae Kwon, Jin Ho Park, Kyungdo Han, Dong Wook Shin
    Cancer.2024;[Epub]     CrossRef
  • Income dynamics and risk of colorectal cancer in individuals with type 2 diabetes: a nationwide population-based cohort study
    Yong-Moon Mark Park, Benjamin C. Amick III, Pearl A. McElfish, Clare C. Brown, Mario Schootman, Marie-Rachelle Narcisse, Seong-Su Lee, Yoon Jin Choi, Kyungdo Han
    Journal of Epidemiology.2024;[Epub]     CrossRef
  • Efficacy of acupuncture on cardiovascular complications in patients with diabetes mellitus in Korea: A nationwide retrospective cohort
    Hyejin Jung, Tiana Won, Ga-Yeon Kim, Jowon Jang, Sujung Yeo, Sabina Lim
    Journal of Integrative Medicine.2023; 21(2): 176.     CrossRef
  • Risk of various cancers in adults with abdominal aortic aneurysms
    Hyung-jin Cho, Ju-hwan Yoo, Mi-hyeong Kim, Kyung-jai Ko, Kang-woong Jun, Kyung-do Han, Jeong-kye Hwang
    Journal of Vascular Surgery.2023; 77(1): 80.     CrossRef
  • Threshold dose–response association between smoking pack-years and the risk of gallbladder cancer: A nationwide cohort study
    Joo-Hyun Park, Jung Yong Hong, Kyungdo Han
    European Journal of Cancer.2023; 180: 99.     CrossRef
  • Sustained Low Income, Income Changes, and Risk of All-Cause Mortality in Individuals With Type 2 Diabetes: A Nationwide Population-Based Cohort Study
    Hong Seok Lee, Jimin Clara Park, Inkwan Chung, Junxiu Liu, Seong-Su Lee, Kyungdo Han
    Diabetes Care.2023; 46(1): 92.     CrossRef
  • Association Between Glycemic Status and the Risk of Kidney Cancer in Men and Women: A Nationwide Cohort Study
    Joo-Hyun Park, Jung Yong Hong, Kyungdo Han, Jay J. Shen
    Diabetes Care.2023; 46(1): 38.     CrossRef
  • Increased end-stage renal disease risk in age-related macular degeneration: a nationwide cohort study with 10-year follow-up
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    Scientific Reports.2023;[Epub]     CrossRef
  • Long‐term mortality and cardiovascular events of seven angiotensin receptor blockers in hypertensive patients: Analysis of a national real‐world database: A retrospective cohort study
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    Health Science Reports.2023;[Epub]     CrossRef
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    Ophthalmology.2023; 130(7): 684.     CrossRef
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    Su-Min Jeong, Jung Eun Yoo, Keun Hye Jeon, Kyungdo Han, Heesun Lee, Dong-Yun Lee, Dong Wook Shin
    BMC Medicine.2023;[Epub]     CrossRef
  • Association of general and central obesity, and their changes with risk of knee osteoarthritis: a nationwide population-based cohort study
    Dojoon Park, Yong-Moon Park, Seung-Hyun Ko, Kang-Se Hyun, Youn-Ho Choi, Dong-Uk Min, Kyungdo Han, Hae-Seok Koh
    Scientific Reports.2023;[Epub]     CrossRef
  • Comparison of Operational Definition of Type 2 Diabetes Mellitus Based on Data from Korean National Health Insurance Service and Korea National Health and Nutrition Examination Survey
    Jong Ha Baek, Yong-Moon Park, Kyung Do Han, Min Kyong Moon, Jong Han Choi, Seung-Hyun Ko
    Diabetes & Metabolism Journal.2023; 47(2): 201.     CrossRef
  • A population-based cohort study on risk factors for acute pancreatitis: A comparison by age group
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    Pancreatology.2023; 23(3): 321.     CrossRef
  • Blood pressure and dementia risk by physical frailty in the elderly: a nationwide cohort study
    Mi Hee Cho, Kyungdo Han, Seungwoo Lee, Su-Min Jeong, Jung Eun Yoo, SangYun Kim, Jinkook Lee, Sohyun Chun, Dong Wook Shin
    Alzheimer's Research & Therapy.2023;[Epub]     CrossRef
  • Cumulative exposure to metabolic syndrome in a national population-based cohort of young adults and sex-specific risk for type 2 diabetes
    Min-Kyung Lee, Jae-Hyuk Lee, Seo Young Sohn, Jiyeon Ahn, Oak-Kee Hong, Mee-Kyoung Kim, Ki-Hyun Baek, Ki-Ho Song, Kyungdo Han, Hyuk-Sang Kwon
    Diabetology & Metabolic Syndrome.2023;[Epub]     CrossRef
  • Age‐Related Macular Degeneration With Visual Disability Is Associated With Cardiovascular Disease Risk in the Korean Nationwide Cohort
    Wonyoung Jung, Kyungdo Han, Bongseong Kim, Sungsoon Hwang, Je Moon Yoon, Junhee Park, Dong Hui Lim, Dong Wook Shin
    Journal of the American Heart Association.2023;[Epub]     CrossRef
  • Association of Metabolic Syndrome Components and Nutritional Status with Kidney Cancer in Young Adult Population: A Nationwide Population-Based Cohort Study in Korea
    Hee Yeon Lee, Kyung-Do Han, In Sook Woo, Hyuk-Sang Kwon
    Biomedicines.2023; 11(5): 1425.     CrossRef
  • Nationwide trends in the prevalence and incidence of depressive disorders and their correlates among adults with disabilities in Korea from 2006 to 2017
    Hwa-Young Lee, So Young Kim, Kyoung Eun Yeob, Yeon Yong Kim, Jong-Hyock Park
    International Journal of Social Psychiatry.2023; 69(7): 1670.     CrossRef
  • Association between glycemic status and the risk of acute pancreatitis: a nationwide population-based study
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    Diabetology & Metabolic Syndrome.2023;[Epub]     CrossRef
  • Association between fatty liver index and risk of end-stage renal disease stratified by kidney function in patients with type 2 diabetes: A nationwide population-based study
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    Diabetes & Metabolism.2023; 49(4): 101454.     CrossRef
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    International Journal of Colorectal Disease.2023;[Epub]     CrossRef
  • Risk of developing chronic kidney disease in young-onset Type 2 diabetes in Korea
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    Scientific Reports.2023;[Epub]     CrossRef
  • A cohort study found a high risk of end-stage kidney disease associated with acromegaly
    Sangmo Hong, Kyung-Soo Kim, Kyungdo Han, Cheol-Young Park
    Kidney International.2023; 104(4): 820.     CrossRef
  • Higher metabolic variability increases the risk of depressive disorder in type 2 diabetes mellitus: a longitudinal nationwide cohort study
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    Frontiers in Psychiatry.2023;[Epub]     CrossRef
  • Association of Sustained Low or High Income and Income Changes With Risk of Incident Type 2 Diabetes Among Individuals Aged 30 to 64 Years
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    JAMA Network Open.2023; 6(8): e2330024.     CrossRef
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    Journal of Korean Medical Science.2023;[Epub]     CrossRef
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    European Heart Journal.2022; 43(15): 1491.     CrossRef
  • Blood Pressure Variability and the Risk of Fracture: A Nationwide Cohort Study
    Jung Eun Yoo, Ji Won Yoon, Hyo Eun Park, Kyungdo Han, Dong Wook Shin
    The Journal of Clinical Endocrinology & Metabolism.2022; 107(4): e1488.     CrossRef
  • Cost-effectiveness analysis of intensive blood pressure control in Korea
    Ye Seol Lee, Hae-Young Lee, Tae Hyun Kim
    Hypertension Research.2022; 45(3): 507.     CrossRef
  • Associations of variability in body weight and glucose levels with the risk of hip fracture in people with diabetes
    Jeongmin Lee, Kyungdo Han, Sang Hyun Park, Mee Kyoung Kim, Dong-Jun Lim, Kun-Ho Yoon, Moo-Il Kang, Seung-Hwan Lee
    Metabolism.2022; 129: 155135.     CrossRef
  • Severe Hypoglycemia Increases Dementia Risk and Related Mortality: A Nationwide, Population-based Cohort Study
    Eugene Han, Kyung-do Han, Byung-Wan Lee, Eun Seok Kang, Bong-Soo Cha, Seung-Hyun Ko, Yong-ho Lee
    The Journal of Clinical Endocrinology & Metabolism.2022; 107(5): e1976.     CrossRef
  • Association between alcohol consumption and pancreatic cancer risk differs by glycaemic status: A nationwide cohort study
    Joo-Hyun Park, Kyungdo Han, Jung Yong Hong, Young Suk Park, Joon Oh Park
    European Journal of Cancer.2022; 163: 119.     CrossRef
  • The risk of dementia in adults with abdominal aortic aneurysm
    Hyung-jin Cho, Ju-hwan Yoo, Mi-hyeong Kim, Kyung-jai Ko, Kang-woong Jun, Kyung-do Han, Jeong-kye Hwang
    Scientific Reports.2022;[Epub]     CrossRef
  • Female Reproductive Factors and the Risk of Bronchiectasis: A Nationwide Population-Based Longitudinal Study
    Bumhee Yang, Dong-Hwa Lee, Kyungdo Han, Hayoung Choi, Hyung Koo Kang, Dong Wook Shin, Hyun Lee
    Biomedicines.2022; 10(2): 303.     CrossRef
  • Incidence of Depression after Traumatic Brain Injury: A Nationwide Longitudinal Study of 2.2 Million Adults
    Yoonjeong Choi, Eun Young Kim, Jiyu Sun, Han-Kyoul Kim, Ye Seol Lee, Byung-Mo Oh, Hye Yoon Park, Ja-Ho Leigh
    Journal of Neurotrauma.2022; 39(5-6): 390.     CrossRef
  • Blood pressure and mortality after percutaneous coronary intervention: a population-based cohort study
    Chung-woo Lee, Joo Kyung Lee, Yeon Joo Choi, Hyunjin Kim, Kyungdo Han, Jin-hyung Jung, Do Hoon Kim, Joo-Hyun Park
    Scientific Reports.2022;[Epub]     CrossRef
  • Impaired Lung Function and Lung Cancer Incidence: A Nationwide Population-Based Cohort Study
    Hye Seon Kang, Yong-Moon Park, Seung-Hyun Ko, Seung Hoon Kim, Shin Young Kim, Chi Hong Kim, Kyungdo Han, Sung Kyoung Kim
    Journal of Clinical Medicine.2022; 11(4): 1077.     CrossRef
  • Analysis of Severe Hypoglycemia Among Adults With Type 2 Diabetes and Nonalcoholic Fatty Liver Disease
    Ji-Yeon Lee, Young-eun Kim, Kyungdo Han, Eugene Han, Byung Wan Lee, Eun Seok Kang, Bong-Soo Cha, Seung-Hyun Ko, Yong-ho Lee
    JAMA Network Open.2022; 5(2): e220262.     CrossRef
  • Smoking, Alcohol Consumption, and the Risk of Thyroid Cancer: A Population-Based Korean Cohort Study of 10 Million People
    Yohwan Yeo, Dong Wook Shin, Kyungdo Han, Dahye Kim, Tae Hyuk Kim, Sohyun Chun, Su-Min Jeong, Yun-Mi Song
    Thyroid.2022; 32(4): 440.     CrossRef
  • The Influence of Obesity and Metabolic Health on Vascular Health
    Eun-Jung Rhee
    Endocrinology and Metabolism.2022; 37(1): 1.     CrossRef
  • Association between lung function and the risk of atrial fibrillation in a nationwide population cohort study
    Su Nam Lee, Seung-Hyun Ko, Sung-Ho Her, Kyungdo Han, Donggyu Moon, Sung Kyoung Kim, Ki-Dong Yoo, Yu-Bae Ahn
    Scientific Reports.2022;[Epub]     CrossRef
  • Hip Fracture Risk According to Diabetic Kidney Disease Phenotype in a Korean Population
    Seung Eun Lee, Juhwan Yoo, Kyoung-Ah Kim, Kyungdo Han, Han Seok Choi
    Endocrinology and Metabolism.2022; 37(1): 148.     CrossRef
  • Medical Utilization and Costs in Preterm Infants in the First 6 Years of Life After Discharge From Neonatal Intensive Care Unit: A Nationwide Population-Based Study in Korea
    Ju Hyun Jin, Sang Ah Lee, Shin Won Yoon
    Journal of Korean Medical Science.2022;[Epub]     CrossRef
  • Low waist circumference prior to percutaneous coronary intervention predict the risk for end-stage renal disease: a nationwide Korean population based-cohort study
    Eun Hui Bae, Sang Yup Lim, Eun Mi Yang, Tae Ryom Oh, Hong Sang Choi, Chang Seong Kim, Seong Kwon Ma, Bongseong Kim, Kyung-Do Han, Soo Wan Kim
    The Korean Journal of Internal Medicine.2022; 37(3): 639.     CrossRef
  • Comparative analysis of cardio-cerebrovascular complications in immigrants and native-born Koreans with diabetes: Risk factors and perspectives
    Hyemin Cho, Sohyun Jeoung, Cinoo Kang, Sunmee Jang, Chaisiri Angkurawaranon
    PLOS ONE.2022; 17(4): e0263046.     CrossRef
  • Changes in Physical Activity and the Risk of Dementia in Patients With New-Onset Type 2 Diabetes: A Nationwide Cohort Study
    Jung Eun Yoo, Kyungdo Han, Bongseong Kim, Sang-Hyun Park, Seon Mee Kim, Hye Soon Park, Ga Eun Nam
    Diabetes Care.2022; 45(5): 1091.     CrossRef
  • Understanding and Utilizing Claim Data from the Korean National Health Insurance Service (NHIS) and Health Insurance Review & Assessment (HIRA) Database for Research
    Dae-Sung Kyoung, Hun-Sung Kim
    Journal of Lipid and Atherosclerosis.2022; 11(2): 103.     CrossRef
  • Annual Trends in the Incidence and Prevalence of Alzheimer's Disease in South Korea: A Nationwide Cohort Study
    Min Seok Baek, Han-Kyeol Kim, Kyungdo Han, Hyuk-Sung Kwon, Han Kyu Na, Chul Hyoung Lyoo, Hanna Cho
    Frontiers in Neurology.2022;[Epub]     CrossRef
  • Combined Effects of Chronic Kidney Disease and Nonalcoholic Fatty Liver Disease on the Risk of Cardiovascular Disease in Patients with Diabetes
    Goh-Eun Chung, Kyungdo Han, Kyu-Na Lee, Eun-Ju Cho, Jung-Ho Bae, Sun-Young Yang, Su-Jong Yu, Seung-Ho Choi, Jeong-Yoon Yim, Nam-Ju Heo
    Biomedicines.2022; 10(6): 1245.     CrossRef
  • Light-to-Moderate Alcohol Consumption Increases the Risk of Biliary Tract Cancer in Prediabetes and Diabetes, but Not in Normoglycemic Status: A Nationwide Cohort Study
    Joo-Hyun Park, Jung Yong Hong, Kyungdo Han, Young Suk Park, Joon Oh Park
    Journal of Clinical Oncology.2022; 40(31): 3623.     CrossRef
  • Nationwide population-based incidence of cancer among patients with HIV/AIDS in South Korea
    Soon Ok Lee, Jeong Eun Lee, Shinwon Lee, Sun Hee Lee, Jin Suk Kang, Hyunjin Son, Hyungi Lee, Jinmi Kim
    Scientific Reports.2022;[Epub]     CrossRef
  • Increased risk of pancreatic cancer in individuals with non-alcoholic fatty liver disease
    Joo-Hyun Park, Jung Yong Hong, Kyungdo Han, Wonseok Kang, Joo Kyung Park
    Scientific Reports.2022;[Epub]     CrossRef
  • Colonoscopy decreases mortality in colorectal cancer patients compared with fecal immunochemical test
    Soo‐Yoon Sung, Hyun Ho Choi, Sukil Kim, Bo Ram Park, Young Ki Kim, Hyung‐Keun Kim, Young‐Seok Cho, Sang Woo Kim, Sung Soo Kim, Hiun‐Suk Chae
    Journal of Gastroenterology and Hepatology.2022; 37(10): 1991.     CrossRef
  • Factors Affecting the Occurrence of Mental Health Problems in Female Cancer Survivors: A Nationwide Cohort Study
    So Young Kim, Yeonju Lee, Sang Baek Koh
    International Journal of Environmental Research and Public Health.2022; 19(14): 8615.     CrossRef
  • Risk for Behçet’s disease gauged via high-density lipoprotein cholesterol: a nationwide population-based study in Korea
    Yeong Ho Kim, Hyun Jee Kim, Jin Woo Park, Kyung Do Han, Yong Gyu Park, Young Bok Lee, Ji Hyun Lee
    Scientific Reports.2022;[Epub]     CrossRef
  • Comparative Effects of Sodium-Glucose Cotransporter 2 Inhibitor and Thiazolidinedione Treatment on Risk of Stroke among Patients with Type 2 Diabetes Mellitus
    Seung Eun Lee, Hyewon Nam, Han Seok Choi, Hoseob Kim, Dae-Sung Kyoung, Kyoung-Ah Kim
    Diabetes & Metabolism Journal.2022; 46(4): 567.     CrossRef
  • Current Trends of Big Data Research Using the Korean National Health Information Database
    Mee Kyoung Kim, Kyungdo Han, Seung-Hwan Lee
    Diabetes & Metabolism Journal.2022; 46(4): 552.     CrossRef
  • Recent Increases in Influenza-Related Hospitalizations, Critical Care Resource Use, and In-Hospital Mortality: A 10-Year Population-Based Study in South Korea
    Tae Hwa Hong, Hyung Seok Lee, Nam-Eun Kim, Kyu Jin Lee, Yong Kyun Kim, Jung Nam An, Joo-Hee Kim, Hyung Won Kim, Sunghoon Park
    Journal of Clinical Medicine.2022; 11(16): 4911.     CrossRef
  • Myocardial Infarction, Stroke, and All-Cause Mortality according to Low-Density Lipoprotein Cholesterol Level in the Elderly, a Nationwide Study
    You-Bin Lee, Minji Koo, Eunjin Noh, Soon Young Hwang, Jung A Kim, Eun Roh, So-hyeon Hong, Kyung Mook Choi, Sei Hyun Baik, Geum Joon Cho, Hye Jin Yoo
    Diabetes & Metabolism Journal.2022; 46(5): 722.     CrossRef
  • Severe hypoglycemia and risk of hospitalization for heart failure in adults with diabetes treated with oral medications with or without insulin: A population-based study
    You-Bin Lee, Yoon-Jong Bae, Hoseob Kim, Jiyun Park, So Yoon Kwon, So Hee Park, Gyuri Kim, Kyu Yeon Hur, Jae Hyeon Kim, Sang-Man Jin
    Diabetes Research and Clinical Practice.2022; 192: 110083.     CrossRef
  • Real-World Prescription Patterns and Barriers Related to the Use of Sodium-Glucose Cotransporter 2 Inhibitors among Korean Patients with Type 2 Diabetes Mellitus and Cardiovascular Disease
    Jong Ha Baek, Ye Seul Yang, Seung-Hyun Ko, Kyung Do Han, Jae Hyeon Kim, Min Kyong Moon, Jong Suk Park, Byung-Wan Lee, Tae Jung Oh, Suk Chon, Jong Han Choi, Kyu Yeon Hur
    Diabetes & Metabolism Journal.2022; 46(5): 701.     CrossRef
  • Association between Age-Related Macular Degeneration and the Risk of Diabetes Mellitus: A Nationwide Cohort Study
    Wonyoung Jung, Je Moon Yoon, Kyungdo Han, Bongseong Kim, Sungsoon Hwang, Dong Hui Lim, Dong Wook Shin
    Biomedicines.2022; 10(10): 2435.     CrossRef
  • Development and Evaluation of Machine Learning-Based High-Cost Prediction Model Using Health Check-Up Data by the National Health Insurance Service of Korea
    Yeongah Choi, Jiho An, Seiyoung Ryu, Jaekyeong Kim
    International Journal of Environmental Research and Public Health.2022; 19(20): 13672.     CrossRef
  • The presence of hypertension during pregnancy determines the future risk of metabolic syndrome: An observational study
    Da-Hye Ju, Hyeyoun Lee, Sang Jin Ha
    Medicine.2022; 101(42): e31272.     CrossRef
  • Association of height loss and cardiovascular disease: Data from a large Korean cohort
    Jeonggeun Moon, Pyung Chun Oh, Kyounghoon Lee, Ho-Jun Jang, Tae-Hoon Kim, Sang-Don Park, Sung Woo Kwon, Min Gyu Kong, Jon Suh, Woong Chol Kang
    Frontiers in Cardiovascular Medicine.2022;[Epub]     CrossRef
  • Association between serum ferritin levels and colorectal cancer risk in Korea
    Hyunho Kim, Kyungdo Han, Seung-Hyun Ko, Ho Jung An
    The Korean Journal of Internal Medicine.2022; 37(6): 1205.     CrossRef
  • Fasting Glucose Variability and the Risk of Dementia in Individuals with Diabetes: A Nationwide Cohort Study
    Da Young Lee, Jaeyoung Kim, Sanghyun Park, So Young Park, Ji Hee Yu, Ji A Seo, Nam Hoon Kim, Hye Jin Yoo, Sin Gon Kim, Kyung Mook Choi, Sei Hyun Baik, Kyungdo Han, Nan Hee Kim
    Diabetes & Metabolism Journal.2022; 46(6): 923.     CrossRef
  • Associations between migraine and major cardiovascular events in type 2 diabetes mellitus
    Dae Young Cheon, Kyungdo Han, Ye Seul Yang, Yerim Kim, Sang-Hwa Lee, Chulho Kim, Jong-Hee Sohn, Mi Sun Oh, Byung-Chul Lee, Minwoo Lee, Kyung-Ho Yu
    Cardiovascular Diabetology.2022;[Epub]     CrossRef
  • The Dose-Response Association between Smoking and the Risk of Gallbladder Cancer Differs by Glycemic Status: A Nationwide Cohort Study
    Joo-Hyun Park, Jung Yong Hong, Kyungdo Han
    SSRN Electronic Journal .2022;[Epub]     CrossRef
  • Threshold Dose-Response Association between Smoking Pack-Years and the Risk of Gallbladder Cancer: A Nationwide Cohort Study
    Joo-Hyun Park, Jung Yong Hong, Kyungdo Han
    SSRN Electronic Journal .2022;[Epub]     CrossRef
  • Cardiovascular and renal effectiveness of empagliflozin in routine care in East Asia: Results from the EMPRISE East Asia study
    Yutaka Seino, Dae Jung Kim, Daisuke Yabe, Elise Chia‐Hui Tan, Wook‐Jin Chung, Kyoung Hwa Ha, Masaomi Nangaku, Koichi Node, Riho Klement, Atsutaka Yasui, Wei‐Yu Lei, Sunwoo Lee, Moe H. Kyaw, Anouk Deruaz‐Luyet, Kimberly G. Brodovicz, Wayne H.‐H. Sheu
    Endocrinology, Diabetes & Metabolism.2021;[Epub]     CrossRef
  • Tooth loss and risk of end‐stage renal disease: A nationwide cohort study
    Kyungdo Han, Jun‐Beom Park
    Journal of Periodontology.2021; 92(3): 371.     CrossRef
  • Both cardiovascular and cerebrovascular events are decreased following long‐term narrowband ultraviolet B phototherapy in patients with vitiligo: a propensity score matching analysis
    J.M. Bae, Y.‐S. Kim, E.H. Choo, M.‐Y. Kim, J.Y. Lee, H.‐O. Kim, Y.M. Park
    Journal of the European Academy of Dermatology and Venereology.2021; 35(1): 222.     CrossRef
  • The risk of hip fractures in individuals over 50 years old with prediabetes and type 2 diabetes – A longitudinal nationwide population-based study
    Ho Youn Park, Kyoungdo Han, Youngwoo Kim, Yoon Hwan Kim, Yoo Joon Sur
    Bone.2021; 142: 115691.     CrossRef
  • Association of Female Reproductive Factors With Incidence of Fracture Among Postmenopausal Women in Korea
    Jung Eun Yoo, Dong Wook Shin, Kyungdo Han, Dahye Kim, Ji Won Yoon, Dong-Yun Lee
    JAMA Network Open.2021; 4(1): e2030405.     CrossRef
  • Status of Diabetic Neuropathy in Korea: A National Health Insurance Service-National Sample Cohort Analysis (2006 to 2015)
    Seong-Su Moon, Chong Hwa Kim, Seon Mee Kang, Eun Sook Kim, Tae Jung Oh, Jae-Seung Yun, Ho Chan Cho, Dae Jung Kim, Tae Sun Park
    Diabetes & Metabolism Journal.2021; 45(1): 115.     CrossRef
  • High-Density Lipoprotein Cholesterol and the Risk of Myocardial Infarction, Stroke, and Cause-Specific Mortality: a Nationwide Cohort Study in Korea
    Yeoree Yang, Kyungdo Han, Sang Hyun Park, Mee Kyoung Kim, Kun-Ho Yoon, Seung-Hwan Lee
    Journal of Lipid and Atherosclerosis.2021; 10(1): 74.     CrossRef
  • Estimated Incidence and Projections of Treatment Cost for Vision-threatening Diabetic Retinopathy in Korea
    Hyo Jin Seong, Jiwon Kim, Sunok Song, Kangju Son, Sungyong Park, Eun Jee Chung
    Journal of the Korean Ophthalmological Society.2021; 62(1): 55.     CrossRef
  • Risk of gastrointestinal cancer in patients with an elevated level of gamma-glutamyltransferase: A nationwide population-based study
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    PLOS ONE.2021; 16(2): e0245052.     CrossRef
  • Descriptive epidemiology on the trends and sociodemographic risk factors of disease burden in years of life lost due to suicide in South Korea from 2000 to 2018
    Keun A Kim, Young-Eun Kim, Seok-Jun Yoon
    BMJ Open.2021; 11(2): e043662.     CrossRef
  • Obesity, Abdominal Obesity and Chronic Kidney Disease in Young Adults: A Nationwide Population-Based Cohort Study
    Eun Hui Bae, Sang Yeob Lim, Jin-Hyung Jung, Tae Ryom Oh, Hong Sang Choi, Chang Seong Kim, Seong Kwon Ma, Kyung-Do Han, Soo Wan Kim
    Journal of Clinical Medicine.2021; 10(5): 1065.     CrossRef
  • Association of particulate matter with autoimmune rheumatic diseases among adults in South Korea
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    Rheumatology.2021; 60(11): 5117.     CrossRef
  • Chronic Kidney Disease Risk of Isolated Systolic or Diastolic Hypertension in Young Adults: A Nationwide Sample Based‐Cohort Study
    Eun Hui Bae, Sang Yeob Lim, Jin‐Hyung Jung, Tae Ryom Oh, Hong Sang Choi, Chang Seong Kim, Seong Kwon Ma, Kyung‐Do Han, Soo Wan Kim
    Journal of the American Heart Association.2021;[Epub]     CrossRef
  • Association between non-alcoholic fatty liver disease and the risk of biliary tract cancers: A South Korean nationwide cohort study
    Joo-Hyun Park, Jung Yong Hong, Minsuk Kwon, Jiyun Lee, Kyungdo Han, In Woong Han, Wonseok Kang, Joo Kyung Park
    European Journal of Cancer.2021; 150: 73.     CrossRef
  • Deep Spinal Infection after Outpatient Epidural Injections for Pain: A Retrospective Sample Cohort Study Using a Claims Database in South Korea
    Chang-Soon Lee, Young Jae Park, Jee Youn Moon, Yong-Chul Kim
    Anesthesiology.2021; 134(6): 925.     CrossRef
  • Obesity, metabolic health, and urological disorders in adults: a nationwide population-based study
    Jong Keun Kim, Young Goo Lee, Kyungdo Han, Jun Hyun Han
    Scientific Reports.2021;[Epub]     CrossRef
  • Risks and Prognoses of Alzheimer's Disease and Vascular Dementia in Patients With Insomnia: A Nationwide Population-Based Study
    Min Seok Baek, Kyungdo Han, Hyuk-Sung Kwon, Yong-ho Lee, Hanna Cho, Chul Hyoung Lyoo
    Frontiers in Neurology.2021;[Epub]     CrossRef
  • Cumulative Exposure to Metabolic Syndrome Components and the Risk of Dementia: A Nationwide Population-Based Study
    Yunjung Cho, Kyungdo Han, Da Hye Kim, Yong-Moon Park, Kun-Ho Yoon, Mee Kyoung Kim, Seung-Hwan Lee
    Endocrinology and Metabolism.2021; 36(2): 424.     CrossRef
  • Changes in Smoking, Alcohol Consumption, and the Risk of Thyroid Cancer: A Population-Based Korean Cohort Study
    Yohwan Yeo, Kyungdo Han, Dong-Wook Shin, Dahye Kim, Su-Min Jeong, Sohyun Chun, In-Young Choi, Keun-Hye Jeon, Tae-Hyuk Kim
    Cancers.2021; 13(10): 2343.     CrossRef
  • Association between obesity and the risk of gastric cancer in premenopausal and postmenopausal women: A nationwide cohort study
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    Journal of Gastroenterology and Hepatology.2021; 36(10): 2834.     CrossRef
  • Reproductive risk factors of pterygium in postmenopausal women: a nationwide study in the Republic of Korea
    Eunhae Shin, Dong Hui Lim, Tae-Young Chung, Gyule Han, Jung Eun Yoo, Keun Hye Jeon, Kyungdo Han, Dong Wook Shin
    Scientific Reports.2021;[Epub]     CrossRef
  • Association of mortality with drug-coated devices in femoropopliteal artery based on the nationwide data
    Hyunsook Choi, Haine Lee, Sang-Soo Lee, Jeonghoon Ahn, Jin Hyun Joh, Moo-Yeol Lee
    Annals of Surgical Treatment and Research.2021; 101(1): 20.     CrossRef
  • Trends and risk factors in severe hypoglycemia among individuals with type 2 diabetes in Korea
    Seung Eun Lee, Kyoung-Ah Kim, Kang Ju Son, Sun Ok Song, Kyeong Hye Park, Se Hee Park, Joo Young Nam
    Diabetes Research and Clinical Practice.2021; 178: 108946.     CrossRef
  • Association between Relative Preference for Vegetables and Meat and Cancer Incidence in Korean Adults: A Nationwide Population-based Retrospective Cohort Study
    Ga-Eun Yie, An Na Kim, Hyun Jeong Cho, Minji Kang, Sungji Moon, Inah Kim, Kwang-Pil Ko, Jung Eun Lee, Sue K. Park
    Korean Journal of Community Nutrition.2021; 26(3): 211.     CrossRef
  • Comparison of fracture risk between type 1 and type 2 diabetes: a comprehensive real-world data
    J. Ha, C. Jeong, K.-D. Han, Y. Lim, M.K. Kim, H.-S. Kwon, K.-H. Song, M.I. Kang, K.-H. Baek
    Osteoporosis International.2021; 32(12): 2543.     CrossRef
  • Dose-Dependent Effect of Smoking on Risk of Diabetes Remains after Smoking Cessation: A Nationwide Population-Based Cohort Study in Korea
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    Diabetes & Metabolism Journal.2021; 45(4): 539.     CrossRef
  • Development and Validation of a Deep Learning Based Diabetes Prediction System Using a Nationwide Population-Based Cohort
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    Diabetes & Metabolism Journal.2021; 45(4): 515.     CrossRef
  • The beneficial effects of menopausal hormone therapy on renal survival in postmenopausal Korean women from a nationwide health survey
    Shin Young Ahn, Yoon Jin Choi, Jieun Kim, Gang Jee Ko, Young Joo Kwon, Kyungdo Han
    Scientific Reports.2021;[Epub]     CrossRef
  • Association of prediabetes, diabetes, and diabetes duration with biliary tract cancer risk: A nationwide cohort study
    Joo-Hyun Park, Jung Yong Hong, Young Suk Park, Gunseog Kang, Kyungdo Han, Joon Oh Park
    Metabolism.2021; 123: 154848.     CrossRef
  • Early mortality and cardiovascular disease, varied association with body mass index and its changes in insulin-treated diabetes: a nationwide study
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    International Journal of Obesity.2021; 45(11): 2482.     CrossRef
  • Patient-Level Cancer Prediction Models From a Nationwide Patient Cohort: Model Development and Validation
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  • Impact of COVID-19 on Heart Failure Patients in South Korea
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    International Heart Journal.2021; 62(5): 1083.     CrossRef
  • Statin use for primary prevention in patients with type 2 diabetes: Can it benefit all ages? – A nationwide propensity-matched cohort study
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    Diabetes Research and Clinical Practice.2021; 180: 109044.     CrossRef
  • Blood pressure prior to percutaneous coronary intervention is associated with the risk of end-stage renal disease: a nationwide population based-cohort study
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    Kidney Research and Clinical Practice.2021; 40(3): 432.     CrossRef
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    Journal of Lipid and Atherosclerosis.2021; 10(3): 303.     CrossRef
  • The association of hepatic steatosis and fibrosis with heart failure and mortality
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    Cardiovascular Diabetology.2021;[Epub]     CrossRef
  • Increased depression risk in patients with abdominal aortic aneurysm: a nationwide cohort study
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    Annals of Surgical Treatment and Research.2021; 101(5): 291.     CrossRef
  • Relationship between blood pressure levels and ischemic stroke, myocardial infarction, and mortality in very elderly patients taking antihypertensives: a nationwide population-based cohort study
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    BMC Geriatrics.2021;[Epub]     CrossRef
  • Risk of Diabetes in Subjects with Positive Fecal Immunochemical Test: A Nationwide Population-Based Study
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    Endocrinology and Metabolism.2021; 36(5): 1069.     CrossRef
  • The Impact of Abdominal Aortic Aneurysm on Cardiovascular Diseases
    Kyung Jai Ko, Ju Hwan Yoo, Hyung Jin Cho, Mi Hyeong Kim, Kang Woong Jun, Kyung Do Han, Jeong Kye Hwang
    International Heart Journal.2021; 62(6): 1235.     CrossRef
  • A Study on Metabolic Health Status as a Risk Factor for Female Bladder Cancer Incidence: Analysis From the National Health Checkups Database of Korea
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    The Korean Journal of Urological Oncology.2021; 19(4): 223.     CrossRef
  • Fasting Glucose Variability as a Risk Indicator for End-Stage Kidney Disease in Patients with Diabetes: A Nationwide Population-Based Study
    Da Young Lee, Jaeyoung Kim, Sanghyun Park, So Young Park, Ji Hee Yu, Ji A. Seo, Nam Hoon Kim, Hye Jin Yoo, Sin Gon Kim, Kyung Mook Choi, Sei Hyun Baik, Kyungdo Han, Nan Hee Kim
    Journal of Clinical Medicine.2021; 10(24): 5948.     CrossRef
  • Female Reproductive Factors and Risk of Bronchiectasis: A Nationwide Population-Based Longitudinal Study
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    SSRN Electronic Journal .2021;[Epub]     CrossRef
  • Changes in Direct Healthcare Costs before and after the Diagnosis of Inflammatory Bowel Disease: A Nationwide Population-Based Study
    Jooyoung Lee, Jong Pil Im, Kyungdo Han, Jihye Kim, Hyun Jung Lee, Jaeyoung Chun, Joo Sung Kim
    Gut and Liver.2020; 14(1): 89.     CrossRef
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    S.J. Yun, J.M. Bae, H. Kim, B.C. Park, J.S. Kim, S.H. Seo, H.H. Ahn, D.Y. Lee, Y.C. Kim, H.J. Park, K.Y. Chung
    Journal of the European Academy of Dermatology and Venereology.2020; 34(4): 746.     CrossRef
  • The prognoses and postoperative outcomes of patients with both colorectal cancer and liver cirrhosis based on a nationwide cohort in Korea
    Nari Shin, Eon Chul Han, Sungho Won, Seung-Bum Ryoo, Eun Kyung Choe, Byung Kwan Park, Kyu Joo Park
    Annals of Surgical Treatment and Research.2020; 99(2): 82.     CrossRef
  • Label Adherence of Direct Oral Anticoagulants Dosing and Clinical Outcomes in Patients With Atrial Fibrillation
    Hee Tae Yu, Pil‐Sung Yang, Eunsun Jang, Tae‐Hoon Kim, Jae‐Sun Uhm, Jong‐Youn Kim, Hui‐Nam Pak, Moon‐Hyoung Lee, Gregory Y. H. Lip, Boyoung Joung
    Journal of the American Heart Association.2020;[Epub]     CrossRef
  • Female reproductive factors and the risk of Parkinson’s disease: a nationwide cohort study
    Jung Eun Yoo, Dong Wook Shin, Wooyoung Jang, Kyungdo Han, Dahye Kim, Hye-Sung Won, Hye Soon Park
    European Journal of Epidemiology.2020; 35(9): 871.     CrossRef
  • The association between nonalcoholic fatty liver disease and esophageal, stomach, or colorectal cancer: National population-based cohort study
    Jung-Min Lee, Yong-Moon Park, Jae-Seung Yun, Yu-Bae Ahn, Kang-Moon Lee, Dae Bum Kim, Ji Min Lee, Kyungdo Han, Seung-Hyun Ko, Ming-Lung Yu
    PLOS ONE.2020; 15(1): e0226351.     CrossRef
  • Body Weight Variability and the Risk of Cardiovascular Outcomes and Mortality in Patients With Type 2 Diabetes: A Nationwide Cohort Study
    Ga Eun Nam, Wonsock Kim, Kyungdo Han, Chung-woo Lee, Yeongkeun Kwon, Byoungduck Han, Seokwon Park, Joo-Hyun Park, Yang-Hyun Kim, Do-Hoon Kim, Seon Mee Kim, Youn Seon Choi, Kyung Hwan Cho, Yong Gyu Park
    Diabetes Care.2020; 43(9): 2234.     CrossRef
  • Female reproductive factors and the risk of lung cancer in postmenopausal women: a nationwide cohort study
    Keun Hye Jeon, Dong Wook Shin, Kyungdo Han, Dahye Kim, Jung Eun Yoo, Su-Min Jeong, Jong ho Cho
    British Journal of Cancer.2020; 122(9): 1417.     CrossRef
  • Gamma-Glutamyl Transferase Variability and Risk of Dementia in Diabetes Mellitus: A Nationwide Population-Based Study
    So-hyeon Hong, Kyungdo Han, Sanghyun Park, Seon Mee Kim, Nan Hee Kim, Kyung Mook Choi, Sei Hyun Baik, Yong Gyu Park, Hye Jin Yoo
    The Journal of Clinical Endocrinology & Metabolism.2020; 105(3): e119.     CrossRef
  • Variability in body weight precedes diagnosis in dementia: A nationwide cohort study
    Jane Ha, Yeongkeun Kwon, Ye‐Ji Kwon, DaHye Kim, Kyungdo Han, Mi Jang, Sungsoo Park, Ga Eun Nam, Yang Hyun Kim, Do Hoon Kim, Yong Gyu Park, Kyung‐Hwan Cho
    Brain and Behavior.2020;[Epub]     CrossRef
  • Anti-diabetic medications and the risk for colorectal cancer: A population-based nested case-control study
    Cheol Min Shin, Nayoung Kim, Kyungdo Han, Bongseong Kim, Jin Hyung Jung, Tae Jung Oh, Dong Ho Lee
    Cancer Epidemiology.2020; 64: 101658.     CrossRef
  • Longitudinal Study of Diabetic Differences between International Migrants and Natives among the Asian Population
    Heng Piao, Jae Moon Yun, Aesun Shin, Belong Cho
    Biomolecules & Therapeutics.2020; 28(1): 110.     CrossRef
  • Dose-response relationship between gamma-glutamyltransferase and the risk of atherosclerotic cardiovascular diseases in Korean adults
    Jooeun Jeon, Dae Hyun Kim, Woojin Kim, Dong-Woo Choi, Keum Ji Jung, Sung-In Jang
    Atherosclerosis.2020; 292: 152.     CrossRef
  • Dipstick proteinuria and cancer incidence: a nationwide population-based study
    Shin Young Ahn, Yoon Jin Choi, Kyungdo Han, Gang Jee Ko, Young Joo Kwon, Yong-Gyu Park
    Journal of Nephrology.2020; 33(5): 1067.     CrossRef
  • Association Between Glycemic Status and the Risk of Parkinson Disease: A Nationwide Population-Based Study
    Sang Youl Rhee, Kyung-Do Han, Hyemi Kwon, Se-Eun Park, Yong-Gyu Park, Yang-Hyun Kim, Soon-Jip Yoo, Eun-Jung Rhee, Won-Young Lee
    Diabetes Care.2020; 43(9): 2169.     CrossRef
  • Gamma glutamyltransferase and risk of dementia in prediabetes and diabetes
    Eugene Han, Ji-Yeon Lee, Kyung-do Han, Hanna Cho, Kwang Joon Kim, Byung-Wan Lee, Eun Seok Kang, Bong-Soo Cha, Zobair M Younossi, Yong-ho Lee
    Scientific Reports.2020;[Epub]     CrossRef
  • Female reproductive factors and the risk of dementia: a nationwide cohort study
    J. E. Yoo, D. W. Shin, K. Han, D. Kim, H.‐S. Won, J. Lee, S. Y. Kim, G. E. Nam, H. S. Park
    European Journal of Neurology.2020; 27(8): 1448.     CrossRef
  • Increased risk of Alzheimer’s disease in patients with psoriasis: a nationwide population-based cohort study
    Miri Kim, Hyo Eun Park, Si-Hyung Lee, Kyungdo Han, Ji Hyun Lee
    Scientific Reports.2020;[Epub]     CrossRef
  • A model to predict risk of stroke in middle-aged adults with type 2 diabetes generated from a nationwide population-based cohort study in Korea
    Mee-Kyoung Kim, Kyungdo Han, Jae-Hyoung Cho, Hyuk-Sang Kwon, Kun-Ho Yoon, Seung-Hwan Lee
    Diabetes Research and Clinical Practice.2020; 163: 108157.     CrossRef
  • Incidence and Risk Factors for Dementia in Type 2 Diabetes Mellitus: A Nationwide Population-Based Study in Korea
    Ji Hee Yu, Kyungdo Han, Sanghyun Park, Hanna Cho, Da Young Lee, Jin-Wook Kim, Ji A Seo, Sin Gon Kim, Sei Hyun Baik, Yong Gyu Park, Kyung Mook Choi, Seon Mee Kim, Nan Hee Kim
    Diabetes & Metabolism Journal.2020; 44(1): 113.     CrossRef
  • Sex differences in smoking, alcohol consumption, and risk of Parkinson's disease: A nationwide cohort study
    Ryul Kim, Dallah Yoo, Yu Jin Jung, Kyungdo Han, Jee-Young Lee
    Parkinsonism & Related Disorders.2020; 71: 60.     CrossRef
  • Blood Pressure Variability and Incidence of New-Onset Atrial Fibrillation
    So-Ryoung Lee, You-Jung Choi, Eue-Keun Choi, Kyung-Do Han, Euijae Lee, Myung-Jin Cha, Seil Oh, Gregory Y.H. Lip
    Hypertension.2020; 75(2): 309.     CrossRef
  • Annual Prevalence, Health Expenditures, and Co-Morbidities Trend of Iron Deficiency Anemia in Korea: National Health Insurance Service Data from 2002 to 2013
    Yoo-Jin Park, Hee-Sook Lim, Tae-Hee Kim
    International Journal of Environmental Research and Public Health.2020; 17(12): 4433.     CrossRef
  • Changes in Metabolic Syndrome Status and Risk of Dementia
    Ji Eun Lee, Dong Wook Shin, Kyungdo Han, Dahye Kim, Jung Eun Yoo, Jinkook Lee, SangYun Kim, Ki Young Son, Belong Cho, Moon Jong Kim
    Journal of Clinical Medicine.2020; 9(1): 122.     CrossRef
  • Blood Pressure Variability and the Risk of Dementia
    Jung Eun Yoo, Dong Wook Shin, Kyungdo Han, Dahye Kim, Seung-Pyo Lee, Su-Min Jeong, Jinkook Lee, SangYun Kim
    Hypertension.2020; 75(4): 982.     CrossRef
  • Gliclazide monotherapy increases risks of all-cause mortality and has similar risk of acute myocardial infarction and stroke with glimepiride monotherapy in Korean type 2 diabetes mellitus
    Eun-Hee Cho, Kyungdo Han, Bongseong Kim, Dae Ho Lee
    Medicine.2020; 99(29): e21236.     CrossRef
  • Risk of Cardiovascular Disease and Chronic Kidney Disease According to 2017 Blood Pressure Categories in Diabetes Mellitus
    Yong Tae Kim, Hyung Joon Chung, Bo Ram Park, Yeon Yong Kim, Jun Hyeok Lee, Dae Ryong Kang, Jang-Young Kim, Mi Young Lee, Jun Young Lee
    Hypertension.2020; 76(3): 766.     CrossRef
  • The Burden of Cervical Cancer in Korea: A Population-Based Study
    Jinhee Kim, Donghwan Lee, Kyung-Bok Son, SeungJin Bae
    International Journal of Environmental Research and Public Health.2020; 17(17): 6308.     CrossRef
  • Underweight increases the risk of primary open-angle glaucoma in diabetes patients
    Kyung-Sun Na, Jin-Ho Kim, Ji-Sun Paik, Won-Kyung Cho, Minji Ha, Yong-Gyu Park, Suk-Woo Yang
    Medicine.2020; 99(10): e19285.     CrossRef
  • Increased risk of idiopathic pulmonary fibrosis in inflammatory bowel disease: A nationwide study
    Jihye Kim, Jaeyoung Chun, Changhyun Lee, Kyungdo Han, Seungho Choi, Jooyoung Lee, Hosim Soh, Kookhwan Choi, Seona Park, Eun Ae Kang, Hyun Jung Lee, Jong Pil Im, Joo Sung Kim
    Journal of Gastroenterology and Hepatology.2020; 35(2): 249.     CrossRef
  • Impact of the timing of Helicobacter pylori eradication on the risk of development of metachronous lesions after treatment of early gastric cancer: a population-based cohort study
    Hyun Ju Kim, Yun Jin Kim, Seung In Seo, Woon Geon Shin, Chan Hyuk Park
    Gastrointestinal Endoscopy.2020; 92(3): 613.     CrossRef
  • Site-specific cancer risk in patients with type 2 diabetes: a nationwide population-based cohort study in Korea
    Suk Kyeong Kim, Ju-Young Jang, Dong-Lim Kim, Young A Rhyu, Suh Eun Lee, Seung-Hyun Ko, Kyungdo Han, Kee-Ho Song
    The Korean Journal of Internal Medicine.2020; 35(3): 641.     CrossRef
  • Cardiovascular Research Using the Korean National Health Information Database
    Eue-Keun Choi
    Korean Circulation Journal.2020; 50(9): 754.     CrossRef
  • Gamma‐glutamyl transferase variability and risk of dementia: A nationwide study
    You‐Bin Lee, Kyungdo Han, Sanghyun Park, Seon Mee Kim, Nan Hee Kim, Kyung Mook Choi, Sei Hyun Baik, Yong Gyu Park, Hye Jin Yoo
    International Journal of Geriatric Psychiatry.2020; 35(10): 1105.     CrossRef
  • Gamma-glutamyl transferase variability can predict the development of end-stage of renal disease: a nationwide population-based study
    Da Young Lee, Kyungdo Han, Ji Hee Yu, Sanghyun Park, Jee-In Heo, Ji A. Seo, Nam Hoon Kim, Hye Jin Yoo, Sin Gon Kim, Seon Mee Kim, Kyung Mook Choi, Sei Hyun Baik, Yong Gyu Park, Nan Hee Kim
    Scientific Reports.2020;[Epub]     CrossRef
  • Hospitalization for heart failure incidence according to the transition in metabolic health and obesity status: a nationwide population-based study
    You-Bin Lee, Da Hye Kim, Seon Mee Kim, Nan Hee Kim, Kyung Mook Choi, Sei Hyun Baik, Yong Gyu Park, Kyungdo Han, Hye Jin Yoo
    Cardiovascular Diabetology.2020;[Epub]     CrossRef
  • Statins and metachronous recurrence after endoscopic resection of early gastric cancer: a nationwide Korean cohort study
    Hyunsoo Chung, Hyun Ju Kim, Hyun Chae Jung, Sang Kil Lee, Sang Gyun Kim
    Gastric Cancer.2020; 23(4): 659.     CrossRef
  • Sex Differences in Cardiovascular Disease Risk by Socioeconomic Status (SES) of Workers Using National Health Information Database
    Hosihn Ryu, Jihyun Moon, Jiyeon Jung
    International Journal of Environmental Research and Public Health.2020; 17(6): 2047.     CrossRef
  • Impact of Mean and Variability of High‐Density Lipoprotein‐Cholesterol on the Risk of Myocardial Infarction, Stroke, and Mortality in the General Population
    Byung‐Hun Han, Kyungdo Han, Kun‐Ho Yoon, Mee Kyoung Kim, Seung‐Hwan Lee
    Journal of the American Heart Association.2020;[Epub]     CrossRef
  • Trends in the prevalence and treatment of bipolar affective disorder in South Korea
    Yoon-Sun Jung, Young-Eun Kim, Arim Kim, Seok-Jun Yoon
    Asian Journal of Psychiatry.2020; 53: 102194.     CrossRef
  • Social Inequalities of Oral Anticoagulation after the Introduction of Non-Vitamin K Antagonists in Patients with Atrial Fibrillation
    Hee Tae Yu, Pil-Sung Yang, Jinseub Hwang, Soorack Ryu, Eunsun Jang, Tae-Hoon Kim, Jae-Sun Uhm, Jong-Youn Kim, Hui-Nam Pak, Moon-Hyoung Lee, Gregory Y.H. Lip, Boyoung Joung
    Korean Circulation Journal.2020; 50(3): 267.     CrossRef
  • Increased incidence of bladder cancer with metabolically unhealthy status: analysis from the National Health Checkup database in Korea
    Jong Wook Kim, Sun Tae Ahn, Mi Mi Oh, Du Geon Moon, Jun Cheon, Kyungdo Han, Seon Mee Kim, Hong Seok Park
    Scientific Reports.2020;[Epub]     CrossRef
  • Prevalence and Current Management of Cardiovascular Risk Factors in Korean Adults Based on Fact Sheets
    Eun-Jung Rhee
    Endocrinology and Metabolism.2020; 35(1): 85.     CrossRef
  • Risk of type 2 diabetes according to the cumulative exposure to metabolic syndrome or obesity: A nationwide population‐based study
    You‐Bin Lee, Da Hye Kim, Seon Mee Kim, Nan Hee Kim, Kyung Mook Choi, Sei Hyun Baik, Yong Gyu Park, Kyungdo Han, Hye Jin Yoo
    Journal of Diabetes Investigation.2020; 11(6): 1583.     CrossRef
  • Sex differences in the blood pressure level associated with increased risks of cardiovascular events: a Korean nationwide population‐based cohort study
    Youn Kyung Kee, Min‐ho Kim, Jongmin Oh, Hyung Jung Oh, Dong‐Ryeol Ryu
    The Journal of Clinical Hypertension.2020; 22(9): 1638.     CrossRef
  • Fasting plasma glucose level and the risk of open angle glaucoma: Nationwide population-based cohort study in Korea
    Jin A. Choi, Yong-Moon Park, Kyungdo Han, Jiyoung Lee, Jae-Seung Yun, Seung-Hyun Ko, Bang V Bui
    PLOS ONE.2020; 15(9): e0239529.     CrossRef
  • Prognostic value of long-term gamma-glutamyl transferase variability in individuals with diabetes: a nationwide population-based study
    Da Young Lee, Kyungdo Han, Ji Hee Yu, Sanghyun Park, Ji A Seo, Nam Hoon Kim, Hye Jin Yoo, Sin Gon Kim, Seon Mee Kim, Kyung Mook Choi, Sei Hyun Baik, Yong Gyu Park, Nan Hee Kim
    Scientific Reports.2020;[Epub]     CrossRef
  • Predicting the Development of Myocardial Infarction in Middle-Aged Adults with Type 2 Diabetes: A Risk Model Generated from a Nationwide Population-Based Cohort Study in Korea
    Seung-Hwan Lee, Kyungdo Han, Hun-Sung Kim, Jae-Hyoung Cho, Kun-Ho Yoon, Mee Kyoung Kim
    Endocrinology and Metabolism.2020; 35(3): 636.     CrossRef
  • Exposure-weighted scoring for metabolic syndrome and the risk of myocardial infarction and stroke: a nationwide population-based study
    Eun Young Lee, Kyungdo Han, Da Hye Kim, Yong-Moon Park, Hyuk-Sang Kwon, Kun-Ho Yoon, Mee Kyoung Kim, Seung-Hwan Lee
    Cardiovascular Diabetology.2020;[Epub]     CrossRef
  • Outcomes in relation to antithrombotic therapy among patients with atrial fibrillation after percutaneous coronary intervention
    Jiesuck Park, Eue-Keun Choi, Kyung-Do Han, Bongseong Kim, You-Jung Choi, So-Ryoung Lee, Jeehoon Kang, Myung-Jin Cha, Kyung Woo Park, Seil Oh, Gregory Y. H. Lip, Chun Chieh Yeh
    PLOS ONE.2020; 15(10): e0240161.     CrossRef
  • Glucose variability and the risks of stroke, myocardial infarction, and all-cause mortality in individuals with diabetes: retrospective cohort study
    Da Young Lee, Kyungdo Han, Sanghyun Park, Ji Hee Yu, Ji A. Seo, Nam Hoon Kim, Hye Jin Yoo, Sin Gon Kim, Kyung Mook Choi, Sei Hyun Baik, Yong Gyu Park, Nan Hee Kim
    Cardiovascular Diabetology.2020;[Epub]     CrossRef
  • Polypharmacy, hospitalization, and mortality risk: a nationwide cohort study
    Tae Ik Chang, Haeyong Park, Dong Wook Kim, Eun Kyung Jeon, Connie M. Rhee, Kamyar Kalantar-Zadeh, Ea Wha Kang, Shin-Wook Kang, Seung Hyeok Han
    Scientific Reports.2020;[Epub]     CrossRef
  • Effect of Variability in Blood Pressure, Glucose and Cholesterol Concentrations, and Body Weight on Emergency Hospitalization and 30‐Day Mortality in the General Population
    Seung‐Hwan Lee, Kyungdo Han, Hyuk‐Sang Kwon, Kun‐Ho Yoon, Mee Kyoung Kim
    Journal of the American Heart Association.2020;[Epub]     CrossRef
  • Incident cardiovascular disease and particulate matter air pollution in South Korea using a population-based and nationwide cohort of 0.2 million adults
    Ok-Jin Kim, Soo Hyun Lee, Si-Hyuck Kang, Sun-Young Kim
    Environmental Health.2020;[Epub]     CrossRef
  • Effects of BMI and LDL-cholesterol change pattern on cardiovascular disease in normal adults and diabetics
    Tae Mi Youk, Min Jin Kang, Sun Ok Song, Eun-Cheol Park
    BMJ Open Diabetes Research & Care.2020; 8(2): e001340.     CrossRef
  • Clinical Outcomes of COVID-19 Patients with Type 2 Diabetes: A Population-Based Study in Korea
    Ji Hong You, Sang Ah Lee, Sung-Youn Chun, Sun Ok Song, Byung-Wan Lee, Dae Jung Kim, Edward J. Boyko
    Endocrinology and Metabolism.2020; 35(4): 901.     CrossRef
  • Variability in estimated glomerular filtration rate and the incidence of type 2 diabetes: a nationwide population-based study
    You-Bin Lee, Da Hye Kim, Eun Roh, So-Hyeon Hong, Jung A Kim, Hye Jin Yoo, Sei Hyun Baik, Kyungdo Han, Kyung Mook Choi
    BMJ Open Diabetes Research & Care.2020; 8(1): e001187.     CrossRef
  • Appropriate Medical Technology in the Era of the 4th Industrial Revolution
    Sang Youl Rhee
    The Korean Journal of Medicine.2019; 94(5): 387.     CrossRef
  • Validation of diagnostic codes of major clinical outcomes in a National Health Insurance database
    Jiesuck Park, Soonil Kwon, Eue-Keun Choi, You-jung Choi, Euijae Lee, Wonseok Choe, So-Ryoung Lee, Myung-Jin Cha, Woo-Hyun Lim, Seil Oh
    International Journal of Arrhythmia.2019;[Epub]     CrossRef
  • Incidence of Prostate Cancer according to Metabolic Health Status: a Nationwide Cohort Study
    Jong Wook Kim, Sun Tae Ahn, Mi Mi Oh, Du Geon Moon, Kyungdo Han, Hong Seok Park
    Journal of Korean Medical Science.2019;[Epub]     CrossRef
  • Increased risk of psoriasis in subjects with abdominal obesity: A nationwide population‐based study
    Ju Hee Han, Ji Hyun Lee, Kyung Do Han, Ha‐Na Kim, Chul Hwan Bang, Young Min Park, Jun Young Lee, Tae Yoon Kim
    The Journal of Dermatology.2019; 46(8): 695.     CrossRef
  • Risk of Incident Dementia According to Metabolic Health and Obesity Status in Late Life: A Population-Based Cohort Study
    Ji-Yeon Lee, Kyungdo Han, Eugene Han, Gyuri Kim, Hanna Cho, Kwang Joon Kim, Byung Wan Lee, Eun Seok Kang, Bong-Soo Cha, Carol Brayne, Yong-ho Lee
    The Journal of Clinical Endocrinology & Metabolism.2019; 104(7): 2942.     CrossRef
  • Blood Pressure and Development of Cardiovascular Disease in Koreans With Type 2 Diabetes Mellitus
    Mee Kyoung Kim, Kyungdo Han, Eun Sil Koh, Eun Sook Kim, Min-Kyung Lee, Ga Eun Nam, Hyuk-Sang Kwon
    Hypertension.2019; 73(2): 319.     CrossRef
  • Association between BMI and risk of severe hypoglycaemia in type 2 diabetes
    J.-S. Yun, Y.-M. Park, K. Han, S.-A. Cha, Y.-B. Ahn, S.-H. Ko
    Diabetes & Metabolism.2019; 45(1): 19.     CrossRef
  • Effects of Variability in Blood Pressure, Glucose, and Cholesterol Concentrations, and Body Mass Index on End-Stage Renal Disease in the General Population of Korea
    Mee Kyoung Kim, Kyungdo Han, Hun-Sung Kim, Yong-Moon Park, Hyuk-Sang Kwon, Kun-Ho Yoon, Seung-Hwan Lee
    Journal of Clinical Medicine.2019; 8(5): 755.     CrossRef
  • Clinical Research from a Health Insurance Database: Practice and Perspective
    Hyunsoo Chung, Su Young Kim, Hyun-Soo Kim
    The Korean Journal of Medicine.2019; 94(6): 463.     CrossRef
  • Obesity Fact Sheet in Korea, 2018: Data Focusing on Waist Circumference and Obesity-Related Comorbidities
    Ga Eun Nam, Yang-Hyun Kim, Kyungdo Han, Jin-Hyung Jung, Yong Gyu Park, Kwan-Woo Lee, Eun-Jung Rhee, Jang Won Son, Seong-Su Lee, Hyuk-Sang Kwon, Won-Young Lee, Soon Jib Yoo
    Journal of Obesity & Metabolic Syndrome.2019; 28(4): 236.     CrossRef
  • Risk of end‐stage renal disease from chronic kidney disease defined by decreased glomerular filtration rate in type 1 diabetes: A comparison with type 2 diabetes and the effect of metabolic syndrome
    You‐Bin Lee, Kyungdo Han, Bongsung Kim, Ji Eun Jun, Seung‐Eun Lee, Jiyeon Ahn, Gyuri Kim, Sang‐Man Jin, Jae Hyeon Kim
    Diabetes/Metabolism Research and Reviews.2019;[Epub]     CrossRef
  • Weight change and mortality and cardiovascular outcomes in patients with new-onset diabetes mellitus: a nationwide cohort study
    Mee Kyoung Kim, Kyungdo Han, Eun Sil Koh, Eun Sook Kim, Min-Kyung Lee, Ga Eun Nam, Hyuk-Sang Kwon
    Cardiovascular Diabetology.2019;[Epub]     CrossRef
  • Risk of early mortality and cardiovascular disease in type 1 diabetes: a comparison with type 2 diabetes, a nationwide study
    You-Bin Lee, Kyungdo Han, Bongsung Kim, Seung-Eun Lee, Ji Eun Jun, Jiyeon Ahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
    Cardiovascular Diabetology.2019;[Epub]     CrossRef
  • Antithrombotic Therapy in Patients With Atrial Fibrillation After Percutaneous Coronary Intervention During 2-Year Follow-Up, from a Nationwide Population Study
    Jiesuck Park, Eue-Keun Choi, Kyung-Do Han, You-Jung Choi, So-Ryoung Lee, Myung-Jin Cha, Jeehoon Kang, Kyung Woo Park, Seil Oh, Gregory Y.H. Lip
    The American Journal of Cardiology.2019; 123(12): 1921.     CrossRef
  • Impact of the Dynamic Change of Metabolic Health Status on the Incident Type 2 Diabetes: A Nationwide Population-Based Cohort Study
    Jung A Kim, Da Hye Kim, Seon Mee Kim, Yong Gyu Park, Nan Hee Kim, Sei Hyun Baik, Kyung Mook Choi, Kyungdo Han, Hye Jin Yoo
    Endocrinology and Metabolism.2019; 34(4): 406.     CrossRef
  • The protective effect of klotho against contrast-associated acute kidney injury via the antioxidative effect
    Hyung Jung Oh, Hyewon Oh, Bo Young Nam, Je Sung You, Dong-Ryeol Ryu, Shin-Wook Kang, Yong Eun Chung
    American Journal of Physiology-Renal Physiology.2019; 317(4): F881.     CrossRef
  • Ankylosing spondylitis: A novel risk factor for atrial fibrillation — A nationwide population-based study
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    International Journal of Cardiology.2019; 275: 77.     CrossRef
  • Impact of Cytomegalovirus Disease on New-Onset Type 2 Diabetes Mellitus: Population-Based Matched Case-Control Cohort Study
    Seul Gi Yoo, Kyung Do Han, Kyoung Hwa Lee, Yeonju La, Da Eun Kwon, Sang Hoon Han
    Diabetes & Metabolism Journal.2019; 43(6): 815.     CrossRef
  • Body Mass Index Variability and Long-term Risk of New-Onset Atrial Fibrillation in the General Population: A Korean Nationwide Cohort Study
    Yeong-Min Lim, Pil-Sung Yang, Eunsun Jang, Hee Tae Yu, Tae-Hoon Kim, Jae-Sun Uhm, Jong-Youn Kim, Hui-Nam Pak, Moon-Hyoung Lee, Boyoung Joung, Gregory Y.H. Lip
    Mayo Clinic Proceedings.2019; 94(2): 225.     CrossRef
  • Effect of hypertension duration and blood pressure level on ischaemic stroke risk in atrial fibrillation: nationwide data covering the entire Korean population
    Tae-Hoon Kim, Pil-Sung Yang, Hee Tae Yu, Eunsun Jang, Hyejung Shin, Ha Yan Kim, Jae-Sun Uhm, Jong-Youn Kim, Jung-Hoon Sung, Hui-Nam Pak, Moon-Hyoung Lee, Boyoung Joung, Gregory Y H Lip
    European Heart Journal.2019; 40(10): 809.     CrossRef
  • Increased Risk of Diabetes in Inflammatory Bowel Disease Patients: A Nationwide Population-Based Study in Korea
    Eun Ae Kang, Kyungdo Han, Jaeyoung Chun, Hosim Soh, Seona Park, Jong Pil Im, Joo Sung Kim
    Journal of Clinical Medicine.2019; 8(3): 343.     CrossRef
  • High Proportion of Adult Cases and Prevalence of Metabolic Syndrome in Type 1 Diabetes Mellitus Population in Korea: A Nationwide Study
    You-Bin Lee, Kyungdo Han, Bongsung Kim, Sang-Man Jin, Seung-Eun Lee, Ji Eun Jun, Jiyeon Ahn, Gyuri Kim, Jae Hyeon Kim
    Diabetes & Metabolism Journal.2019; 43(1): 76.     CrossRef
  • Long-term evolution of direct healthcare costs for inflammatory bowel diseases: a population-based study (2006–2015)
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    Scandinavian Journal of Gastroenterology.2019; 54(4): 419.     CrossRef
  • Association Between Systolic and Diastolic Blood Pressure Variability and the Risk of End-Stage Renal Disease
    Eun Hui Bae, Sang Yup Lim, Kyung-Do Han, Tae Ryom Oh, Hong Sang Choi, Chang Seong Kim, Seong Kwon Ma, Soo Wan Kim
    Hypertension.2019; 74(4): 880.     CrossRef
  • Effect of Dipeptidyl Peptidase-4 Inhibitors on the Risk of Bone Fractures in a Korean Population
    Morena Ustulin, So Young Park, Hangseok Choi, Suk Chon, Jeong-Taek Woo, Sang Youl Rhee
    Journal of Korean Medical Science.2019;[Epub]     CrossRef
  • Temporal trends in prevalence and antithrombotic treatment among Asians with atrial fibrillation undergoing percutaneous coronary intervention: A nationwide Korean population-based study
    Jiesuck Park, Eue-Keun Choi, Kyung-Do Han, You-jung Choi, Euijae Lee, Wonseok Choe, So-Ryoung Lee, Myung-Jin Cha, Woo-Hyun Lim, Jeehoon Kang, Kyung Woo Park, Seil Oh, Gregory Y. H. Lip, Chiara Lazzeri
    PLOS ONE.2019; 14(1): e0209593.     CrossRef
  • Severe hypoglycemia and the risk of cardiovascular disease and mortality in type 2 diabetes: a nationwide population-based cohort study
    Jae-Seung Yun, Yong-Moon Park, Kyungdo Han, Seon-Ah Cha, Yu-Bae Ahn, Seung-Hyun Ko
    Cardiovascular Diabetology.2019;[Epub]     CrossRef
  • Association of Exposure to Diagnostic Low-Dose Ionizing Radiation With Risk of Cancer Among Youths in South Korea
    Jae-Young Hong, Kyungdo Han, Jin-Hyung Jung, Jung Sun Kim
    JAMA Network Open.2019; 2(9): e1910584.     CrossRef
  • Cholesterol levels and development of cardiovascular disease in Koreans with type 2 diabetes mellitus and without pre-existing cardiovascular disease
    Mee Kyoung Kim, Kyungdo Han, Han Na Joung, Ki-Hyun Baek, Ki-Ho Song, Hyuk-Sang Kwon
    Cardiovascular Diabetology.2019;[Epub]     CrossRef
  • The effects of blood pressure components on cardiovascular events in a Korean hypertensive population according to age and sex
    Eungyu Kang, Seulbi Lee, Eunhee Ha, Hyung Jung Oh, Dong-Ryeol Ryu
    Medicine.2019; 98(33): e16676.     CrossRef
  • Cost Effectiveness of Quadrivalent Influenza Vaccines Compared with Trivalent Influenza Vaccines in Young Children and Older Adults in Korea
    Yun-Kyung Kim, Joon Young Song, Hyeongap Jang, Tae Hyun Kim, Heejo Koo, Lijoy Varghese, Euna Han
    PharmacoEconomics.2018; 36(12): 1475.     CrossRef
  • Trends in the prevalence of metabolic syndrome and its components in South Korea: Findings from the Korean National Health Insurance Service Database (2009–2013)
    Seung Eun Lee, Kyungdo Han, Yu Mi Kang, Seon-Ok Kim, Yun Kyung Cho, Kyung Soo Ko, Joong-Yeol Park, Ki-Up Lee, Eun Hee Koh, Ying-Mei Feng
    PLOS ONE.2018; 13(3): e0194490.     CrossRef
  • Appropriate Amount of Regular Exercise Is Associated with a Reduced Mortality Risk
    DA YOUNG LEE, EUN-JUNG RHEE, JUNG HWAN CHO, HYEMI KWON, SE EUN PARK, YANG-HYUN KIM, KYUNGDO HAN, YONG-KYU PARK, SOON JIB YOO, WON-YOUNG LEE
    Medicine & Science in Sports & Exercise.2018; 50(12): 2451.     CrossRef
  • Association of blood pressure components with mortality and cardiovascular events in prehypertensive individuals: a nationwide population-based cohort study
    Hyung Jung Oh, Seulbi Lee, Eun-Kyung Lee, Oesook Lee, Eunhee Ha, Eun-Mi Park, Seung-Jung Kim, Duk-Hee Kang, Kyu Bok Choi, Seung Jun Kim, Dong-Ryeol Ryu
    Annals of Medicine.2018; 50(5): 443.     CrossRef
  • Trends in diabetic retinopathy and related medical practices among type 2 diabetes patients: Results from the National Insurance Service Survey 2006–2013
    Su Jeong Song, Kyungdo Han, Kyung Seek Choi, Seung‐Hyun Ko, Eun‐jung Rhee, Cheol‐Young Park, Joong‐Yeol Park, Ki‐Up Lee, Kyung‐Soo Ko
    Journal of Diabetes Investigation.2018; 9(1): 173.     CrossRef
  • Optimal Blood Pressure in Elderly Hypertensive Subjects: A Korean National Health Insurance Service Health Examinee Cohort Study
    Jiwon Seo, Chan Joo Lee, Jinseub Hwang, Jaewon Oh, Sang-Hak Lee, Seok-Min Kang, Donghoon Choi, Hyeon-Chang Kim, Sungha Park
    American Journal of Hypertension.2018; 31(9): 1033.     CrossRef
  • Association between diabetes and asthma
    Ji Yeon Baek, Seung Eun Lee, Kyungdo Han, Eun Hee Koh
    Annals of Allergy, Asthma & Immunology.2018; 121(6): 699.     CrossRef
  • Increased risk of open‐angle glaucoma among patients with diabetes mellitus: a 10‐year follow‐up nationwide cohort study
    Tyler Hyungtaek Rim, Sang Yeop Lee, Hyoung Won Bae, Gong Je Seong, Sung Soo Kim, Chan Yun Kim
    Acta Ophthalmologica.2018;[Epub]     CrossRef
  • Age Threshold for Ischemic Stroke Risk in Atrial Fibrillation
    Tae-Hoon Kim, Pil-Sung Yang, Hee Tae Yu, Eunsun Jang, Jae-Sun Uhm, Jong-Youn Kim, Hui-Nam Pak, Moon-Hyoung Lee, Boyoung Joung, Gregory Y.H. Lip
    Stroke.2018; 49(8): 1872.     CrossRef
  • Impact of Renal Function on Outcomes With Edoxaban in Real-World Patients With Atrial Fibrillation
    Hee Tae Yu, Pil-Sung Yang, Tae-Hoon Kim, Eunsun Jang, Daehoon Kim, Jae-Sun Uhm, Jong-Youn Kim, Hui-Nam Pak, Moon-Hyoung Lee, Gregory Y.H. Lip, Boyoung Joung
    Stroke.2018; 49(10): 2421.     CrossRef
  • Dipstick proteinuria predicts all-cause mortality in general population: A study of 17 million Korean adults
    Yeongkeun Kwon, Kyungdo Han, Yang Hyun Kim, Sungsoo Park, Do Hoon Kim, Yong Kyun Roh, Yong-Gyu Park, Kyung-Hwan Cho, Tatsuo Shimosawa
    PLOS ONE.2018; 13(6): e0199913.     CrossRef
  • Past and Current Status of Adult Type 2 Diabetes Mellitus Management in Korea: A National Health Insurance Service Database Analysis
    Seung-Hyun Ko, Kyungdo Han, Yong-ho Lee, Junghyun Noh, Cheol-Young Park, Dae-Jung Kim, Chang Hee Jung, Ki-Up Lee, Kyung-Soo Ko
    Diabetes & Metabolism Journal.2018; 42(2): 93.     CrossRef
  • Associations of Variability in Blood Pressure, Glucose and Cholesterol Concentrations, and Body Mass Index With Mortality and Cardiovascular Outcomes in the General Population
    Mee Kyoung Kim, Kyungdo Han, Yong-Moon Park, Hyuk-Sang Kwon, Gunseog Kang, Kun-Ho Yoon, Seung-Hwan Lee
    Circulation.2018; 138(23): 2627.     CrossRef
  • Effects of smoking habit change on all-cause mortality and cardiovascular diseases among patients with newly diagnosed diabetes in Korea
    Mi Hee Cho, Kiheon Lee, Sang Min Park, Jooyoung Chang, Seulggie Choi, Kyuwoong Kim, Hye-Yeon Koo, Ji-Hye Jun, Sung Min Kim
    Scientific Reports.2018;[Epub]     CrossRef
  • Severe hypoglycemia is a risk factor for atrial fibrillation in type 2 diabetes mellitus: Nationwide population-based cohort study
    Seung-Hyun Ko, Yong-Moon Park, Jae-Seung Yun, Seon-Ah Cha, Eue-Keun Choi, Kyungdo Han, Eugene Han, Yong-ho Lee, Yu-Bae Ahn
    Journal of Diabetes and its Complications.2018; 32(2): 157.     CrossRef
  • Association Between Diabetic Retinopathy and Parkinson Disease: The Korean National Health Insurance Service Database
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    The Journal of Clinical Endocrinology & Metabolism.2018; 103(9): 3231.     CrossRef
  • Variability in metabolic parameters and risk of dementia: a nationwide population-based study
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    Alzheimer's Research & Therapy.2018;[Epub]     CrossRef
  • Factors associated with continued smoking after the diagnosis of type 2 diabetes: a retrospective study in the Korean cohort
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    BMJ Open.2018; 8(6): e020160.     CrossRef
  • Impact of diabetes mellitus and chronic liver disease on the incidence of dementia and all-cause mortality among patients with dementia
    Hyun Min Kim, Yong-ho Lee, Kyungdo Han, Byung-Wan Lee, Eun Seok Kang, Jaetaek Kim, Bong-Soo Cha
    Medicine.2017; 96(47): e8753.     CrossRef
  • Recent Shift of Body Mass Index Distribution in Korea: a Population-based Korea National Health Insurance Database, 2002–2013
    Yeong Sook Yoon, Sang Woo Oh
    Journal of Korean Medical Science.2017; 32(3): 434.     CrossRef
  • Trends in the incidence and prevalence of atrial fibrillation and estimated thromboembolic risk using the CHA2DS2-VASc score in the entire Korean population
    So-Ryoung Lee, Eue-Keun Choi, Kyung-Do Han, Myung-Jin Cha, Seil Oh
    International Journal of Cardiology.2017; 236: 226.     CrossRef
  • Increased risk for diabetes development in subjects with large variation in total cholesterol levels in 2,827,950 Koreans: A nationwide population-based study
    Eun-Jung Rhee, Kyungdo Han, Seung-Hyun Ko, Kyung-Soo Ko, Won-Young Lee, Yan Li
    PLOS ONE.2017; 12(5): e0176615.     CrossRef
  • Trends in the pervasiveness of type 2 diabetes, impaired fasting glucose and co-morbidities during an 8-year-follow-up of nationwide Korean population
    Junghyun Noh, Kyung-Do Han, Seung-Hyun Ko, Kyung Soo Ko, Cheol-Young Park
    Scientific Reports.2017;[Epub]     CrossRef
  • Blood Pressure Control During Chronic Kidney Disease Progression
    Seulbi Lee, Hyung Jung Oh, Eun-Kyung Lee, Oesook Lee, Eunhee Ha, Seung-Jung Kim, Duk-Hee Kang, Kyu Bok Choi, Dong-Ryeol Ryu
    American Journal of Hypertension.2017; 30(6): 610.     CrossRef
  • Association Among Obesity, Metabolic Health, and the Risk for Colorectal Cancer in the General Population in Korea Using the National Health Insurance Service–National Sample Cohort
    Cheol Min Shin, Kyungdo Han, Dong Ho Lee, Yoon Jin Choi, Nayoung Kim, Young Soo Park, Hyuk Yoon
    Diseases of the Colon & Rectum.2017; 60(11): 1192.     CrossRef
  • Cholesterol variability and the risk of mortality, myocardial infarction, and stroke: a nationwide population-based study
    Mee Kyoung Kim, Kyungdo Han, Hun-Sung Kim, Yong-Moon Park, Hyuk-Sang Kwon, Kun-Ho Yoon, Seung-Hwan Lee
    European Heart Journal.2017; 38(48): 3560.     CrossRef
  • Relation Between Blood Pressure and Clinical Outcome in Hypertensive Subjects With Previous Stroke
    Chan Joo Lee, Jinseub Hwang, Jaewon Oh, Sang‐Hak Lee, Seok‐Min Kang, Hyeon Chang Kim, Sungha Park
    Journal of the American Heart Association.2017;[Epub]     CrossRef
  • Femur Fractures in Parkinsonism: Analysis of a National Sample Cohort in South Korea
    Soo Jeong An, Seung-Hwan Lee, Seo-Young Lee, Jae-Woo Kwon, Seung-Joon Lee, Young-Ju Kim
    Journal of Clinical Neurology.2017; 13(4): 380.     CrossRef
  • Improved trends in cardiovascular complications among subjects with type 2 diabetes in Korea: a nationwide study (2006–2013)
    Chang Hee Jung, Jin Ook Chung, Kyungdo Han, Seung-Hyun Ko, Kyung Soo Ko, Joong-Yeol Park
    Cardiovascular Diabetology.2017;[Epub]     CrossRef
  • Trends of antidiabetic drug use in adult type 2 diabetes in Korea in 2002–2013
    Seung-Hyun Ko, Dae-Jung Kim, Jong-Heon Park, Cheol-Young Park, Chang Hee Jung, Hyuk-Sang Kwon, Joong-Yeol Park, Kee-Ho Song, Kyungdo Han, Ki-Up Lee, Kyung-Soo Ko
    Medicine.2016; 95(27): e4018.     CrossRef
  • Obesity, metabolic health, and mortality in adults: a nationwide population-based study in Korea
    Hae Kyung Yang, Kyungdo Han, Hyuk-Sang Kwon, Yong-Moon Park, Jae-Hyoung Cho, Kun-Ho Yoon, Moo-Il Kang, Bong-Yun Cha, Seung-Hwan Lee
    Scientific Reports.2016;[Epub]     CrossRef
Letter
Letter: Cardiovascular Disease Predicts Severe Hypoglycemia in Patients with Type 2 Diabetes (Diabetes Metab J 2015;39:498-506)
Mi-Kyung Kim
Diabetes Metab J. 2016;40(1):83-84.   Published online February 19, 2016
DOI: https://doi.org/10.4093/dmj.2016.40.1.83
  • 2,800 View
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Response
Response: Cardiovascular Disease Predicts Severe Hypoglycemia in Patients with Type 2 Diabetes (Diabetes Metab J 2015;39:498-506)
Jae-Seung Yun, Yu-Bae Ahn
Diabetes Metab J. 2016;40(1):85-86.   Published online February 19, 2016
DOI: https://doi.org/10.4093/dmj.2016.40.1.85
  • 2,853 View
  • 29 Download
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Corrigendum
Corrigendum: Prevalence of Depression and Glucose Abnormality in an Urbanizing Rural Population of Bangladesh
Khurshid Natasha, Akhtar Hussain, A. K. Azad Khan, Bishwajit Bhowmik
Diabetes Metab J. 2016;40(1):87-87.   Published online February 19, 2016
DOI: https://doi.org/10.4093/dmj.2016.40.1.87
  • 3,934 View
  • 26 Download
  • 2 Crossref
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