Fig. 1Percentage of patients classified as high risk by Framingham Risk score (FRS) and UKPDS, United Kingdom Prospective Diabetes Study (UKPDS) using different cut-points. CHD, coronary heart disease.
Table 1Sociodemographic and biochemical characteristics
Characteristic |
Total |
Male |
Female |
P valuea
|
No. (%) |
489 |
216 (44) |
273 (56) |
|
Age, yr |
49.8±10.1 |
49.3±10.5 |
49.9±9.8 |
0.735 |
Height, cm |
159.1±8.7 |
164.6±7.6 |
154.7±6.9 |
<0.001 |
Weight, kg |
69.1±12.6 |
71.1±12.4 |
67.6±12.6 |
0.003 |
BMI, kg/m2
|
27.4±5.0 |
26.2±4.2 |
28.3±5.4 |
<0.001 |
WC, cm |
97.2±12.3 |
96±12.2 |
98.1±12.4 |
0.071 |
SBP, mm Hg |
132±16 |
132±17 |
131±15 |
0.462 |
DBP, mm Hg |
84±10 |
85±10 |
83±9 |
0.085 |
HbA1c, % |
8.8±2.3 |
8.6±2.3 |
8.9±2.4 |
0.138 |
TC, mg/dL |
205±55 |
199±52 |
210±57 |
0.032 |
HDL-C, mg/dL |
43±9 |
42±10 |
43±8 |
0.334 |
LDL-C, mg/dL |
118±38 |
115±36 |
120±39 |
0.110 |
TG, mg/dL |
192±126 |
182±78 |
199±153 |
0.106 |
Smokers, n (%) |
63 (13) |
62 (29) |
1 (0.4) |
<0.001 |
Table 2Distribution of subjects according to classification as high risk using FRS and UKPDS
FRS assessment |
UKPDS assessment |
Not high risk |
High risk |
Not high risk |
341 (69.7) |
46 (9.4) |
High risk |
42 (8.6) |
60 (12.3) |
Table 3Characteristics of individuals with a discrepancy in coronary heart disease risk using FRS and UKPDS
Characteristic |
High risk using UKPDS but not FRS (n=46, 9.4%) |
High risk using FRS but not UKPDS (n=42, 8.6%) |
P value |
Women |
17 (37) |
27 (64) |
0.010 |
Age, yr |
54.3±9.7 |
57.2±5.6 |
0.080 |
Age ≥50 |
35 (76.1) |
41 (98) |
<0.001 |
Body mass index, kg/m2
|
26.6±3.3 |
27.9±5.4 |
0.195 |
Smoking |
10 (22) |
8 (19) |
0.755 |
Glycosylated hemoglobin, % |
11.4±2.5 |
7.6±1.5 |
<0.001 |
Total cholesterol, mg/dL |
215±49 |
230±57 |
0.187 |
High density lipoprotein cholesterol, mg/dL |
41±10 |
41±8 |
0.940 |
Low density lipoprotein cholesterol, mg/dL |
123±34 |
131±41 |
0.378 |
Triglycerides, mg/dL |
218±152 |
221±115 |
0.937 |
Systolic blood pressure, mm Hg |
127±14 |
142±13 |
<0.001 |
Diastolic blood pressure, mm Hg |
80.41±9.23 |
89±10 |
<0.001 |
Hypertension >130/80 mm Hg |
14 (30) |
33 (79) |
<0.001 |
Table 4Comparison of estimated coronary heart disease risk scores according to FRS and UKPDS
|
FRS |
UKPDS |
Total |
Male |
Female |
Total |
Male |
Female |
Risk, n (%) |
489 (100) |
216 (44) |
273 (56) |
489 (100) |
216 (44) |
273 (56) |
High |
104 (21) |
55 (26) |
49 (18) |
106 (22) |
73 (34) |
33 (12) |
Moderate |
116 (24) |
46 (21) |
70 (26) |
57 (12) |
36 (17) |
21 (8) |
Low |
124 (25) |
57 (26) |
67 (25) |
89 (18) |
37 (17) |
52 (19) |
Very low |
145 (30) |
58 (27) |
87 (32) |
237 (49) |
70 (32) |
167 (61) |