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Original Articles
- Genetics
- The rs2304256 Polymorphism in TYK2 Gene Is Associated with Protection for Type 1 Diabetes Mellitus
- Felipe Mateus Pellenz, Cristine Dieter, Guilherme Coutinho Kullmann Duarte, Luís Henrique Canani, Bianca Marmontel de Souza, Daisy Crispim
- Diabetes Metab J. 2021;45(6):899-908. Published online May 24, 2021
- DOI: https://doi.org/10.4093/dmj.2020.0194
- 4,759 View
- 157 Download
- 1 Web of Science
- 3 Crossref
-
Graphical Abstract
Abstract
PDF
PubReader 
ePub - Background
Tyrosine kinase 2 (TYK2) is a candidate gene for type 1 diabetes mellitus (T1DM) since it plays an important role in regulating apoptotic and pro-inflammatory pathways in pancreatic β-cells through modulation of the type I interferon signaling pathway. The rs2304256 single nucleotide polymorphism (SNP) in TYK2 gene has been associated with protection for different autoimmune diseases. However, to date, only two studies have evaluated the association between this SNP and T1DM, with discordant results. This study thus aimed to investigate the association between the TYK2 rs2304256 SNP and T1DM in a Southern Brazilian population.
Methods
This case-control study comprised 478 patients with T1DM and 518 non-diabetic subjects. The rs2304256 (C/A) SNP was genotyped by real-time polymerase chain reaction technique using TaqMan minor groove binder (MGB) probes.
Results
Genotype and allele frequencies of the rs2304256 SNP differed between T1DM patients and non-diabetic subjects (P<0.0001 and P=0.001, respectively). Furthermore, the A allele was associated with protection against T1DM under recessive (odds ratio [OR], 0.482; 95% confidence interval [CI], 0.288 to 0.806) and additive (OR, 0.470; 95% CI, 0.278 to 0.794) inheritance models, adjusting for human leukocyte antigen (HLA) DR/DQ genotypes, gender, and ethnicity.
Conclusion
The A/A genotype of TYK2 rs2304256 SNP is associated with protection against T1DM in a Southern Brazilian population. -
Citations
Citations to this article as recorded by
- Associations of genetic variants within TYK2 with pulmonary tuberculosis among Chinese population
Mingwu Zhang, Zhengwei Liu, Yelei Zhu, Kunyang Wu, Lin Zhou, Ying Peng, Junhang Pan, Bin Chen, Xiaomeng Wang, Songhua Chen
Molecular Genetics & Genomic Medicine.2024;[Epub] CrossRef - Host genetic variants associated with COVID-19 reconsidered in a Slovak cohort
Maria Skerenova, Michal Cibulka, Zuzana Dankova, Veronika Holubekova, Zuzana Kolkova, Vincent Lucansky, Dana Dvorska, Andrea Kapinova, Michaela Krivosova, Martin Petras, Eva Baranovicova, Ivana Baranova, Elena Novakova, Peter Liptak, Peter Banovcin, Anna
Advances in Medical Sciences.2024; 69(1): 198. CrossRef - Cross-Domain Text Mining of Pathophysiological Processes Associated with Diabetic Kidney Disease
Krutika Patidar, Jennifer H. Deng, Cassie S. Mitchell, Ashlee N. Ford Versypt
International Journal of Molecular Sciences.2024; 25(8): 4503. CrossRef
- Associations of genetic variants within TYK2 with pulmonary tuberculosis among Chinese population
- Genetics
- Association of Combined TCF7L2 and KCNQ1 Gene Polymorphisms with Diabetic Micro- and Macrovascular Complications in Type 2 Diabetes Mellitus
- Rujikorn Rattanatham, Nongnuch Settasatian, Nantarat Komanasin, Upa Kukongviriyapan, Kittisak Sawanyawisuth, Phongsak Intharaphet, Vichai Senthong, Chatri Settasatian
- Diabetes Metab J. 2021;45(4):578-593. Published online March 22, 2021
- DOI: https://doi.org/10.4093/dmj.2020.0101
- 5,610 View
- 145 Download
- 8 Web of Science
- 7 Crossref
-
Abstract
PDF
Supplementary MaterialPubReader ePub - Background
Vascular complications are the major morbid consequences of type 2 diabetes mellitus (T2DM). The transcription factor 7-like 2 (TCF7L2), potassium voltage-gated channel subfamily Q member 1 (KCNQ1), and inwardly-rectifying potassium channel, subfamily J, member 11 gene (KCNJ11) are common T2DM susceptibility genes in various populations. However, the associations between polymorphisms in these genes and diabetic complications are controversial. This study aimed to investigate the effects of combined gene-polymorphisms within TCF7L2, KCNQ1, and KCNJ11 on vascular complications in Thai subjects with T2DM.
Methods
We conducted a case-control study comprising 960 T2DM patients and 740 non-diabetes controls. Single nucleotide polymorphisms in TCF7L2, KCNQ1, and KCNJ11 were genotyped and evaluated for their association with diabetic vascular complications.
Results
The gene variants TCF7L2 rs290487-T, KCNQ1 rs2237892-C, and KCNQ1 rs2237897-C were associated with increased risk of T2DM. TCF7L2 rs7903146-C, TCF7L2 rs290487-C, KCNQ1 rs2237892-T, and KCNQ1 rs2237897-T revealed an association with hypertension. The specific combination of risk-alleles that have effects on T2DM and hypertension, TCF7L2 rs7903146-C, KCNQ1 rs2237892-C, and KCNQ1 rs2237897-T, as genetic risk score (GRS), pronounced significant association with coronary artery disease (CAD), cumulative nephropathy and CAD, and cumulative microvascular and macrovascular complications (respective odds ratios [ORs] with 95% confidence interval [95% CI], comparing between GRS 2–3 and GRS 5–6, were 7.31 [2.03 to 26.35], 3.92 [1.75 to 8.76], and 2.33 [1.13 to 4.79]).
Conclusion
This study demonstrated, for the first time, the effect conferred by specific combined genetic variants in TCF7L2 and KCNQ1 on diabetic vascular complications, predominantly with nephropathy and CAD. Such a specific pattern of gene variant combination may implicate in the progression of T2DM and life-threatening vascular complications. -
Citations
Citations to this article as recorded by- Genetic Risk Scores Identify People at High Risk of Developing Diabetic Kidney Disease: A Systematic Review
Aleena Shujaat Ali, Cecilia Pham, Grant Morahan, Elif Ilhan Ekinci
The Journal of Clinical Endocrinology & Metabolism.2024; 109(5): 1189. CrossRef - Saudi Community-Based Screening Study on Genetic Variants in β-Cell Dysfunction and Its Role in Women with Gestational Diabetes Mellitus
Amal F. Alshammary, Malak Mohammed Al-Hakeem, Imran Ali Khan
Genes.2023; 14(4): 924. CrossRef - Association between KCNJ11 E23K polymorphism and the risk of type 2 diabetes mellitus: A global meta-analysis
Yaxuan Ren, Wenfei Zhu, Jikang Shi, Aiyu Shao, Yi Cheng, Yawen Liu
Journal of Diabetes and its Complications.2022; 36(5): 108170. CrossRef - Association between carotid atherosclerosis and presence of intracranial atherosclerosis using three-dimensional high-resolution vessel wall magnetic resonance imaging in asymptomatic patients with type 2 diabetes
Ji Eun Jun, You-Cheol Hwang, Kyu Jeong Ahn, Ho Yeon Chung, Geon-Ho Jahng, Soonchan Park, In-Kyung Jeong, Chang-Woo Ryu
Diabetes Research and Clinical Practice.2022; 191: 110067. CrossRef - Multiple Single Nucleotide Polymorphism Testing Improves the Prediction of Diabetic Retinopathy Risk with Type 2 Diabetes Mellitus
Yu-Ting Hsiao, Feng-Chih Shen, Shao-Wen Weng, Pei-Wen Wang, Yung-Jen Chen, Jong-Jer Lee
Journal of Personalized Medicine.2021; 11(8): 689. CrossRef - Oxidative Stress Genes in Diabetes Mellitus Type 2: Association with Diabetic Kidney Disease
Athanasios Roumeliotis, Stefanos Roumeliotis, Fotis Tsetsos, Marianthi Georgitsi, Panagiotis I. Georgianos, Aikaterini Stamou, Anna Vasilakou, Kalliopi Kotsa, Xanthippi Tsekmekidou, Peristera Paschou, Stylianos Panagoutsos, Vassilios Liakopoulos, Elena Az
Oxidative Medicine and Cellular Longevity.2021; 2021: 1. CrossRef - Analysis of the association of polymorphisms of genes markers functions of endothelium and vascular-plate hemostasis with development of diabetic foot syndrome
N. I. Troitskaya, K. G. Shapovalov, V. A. Mudrov
Acta Biomedica Scientifica.2021; 6(4): 18. CrossRef
- Genetic Risk Scores Identify People at High Risk of Developing Diabetic Kidney Disease: A Systematic Review
- Genetics
APO A2 -265T /C Polymorphism Is Associated with Increased Inflammatory Responses in Patients with Type 2 Diabetes Mellitus- Fariba Koohdani, Haleh Sadrzadeh-Yeganeh, Mahmoud Djalali, Mohammadreza Eshraghian, Elham Zamani, Gity Sotoudeh, Mohammad-Ali Mansournia, Laleh Keramat
- Diabetes Metab J. 2016;40(3):222-229. Published online June 20, 2016
- DOI: https://doi.org/10.4093/dmj.2016.40.3.222
- 3,137 View
- 28 Download
- 12 Web of Science
- 11 Crossref
-
Abstract
PDFPubReader
Background Apolipoprotein A2 (
APO A2 ) is the second most abundant structural apolipoprotein in high density lipoprotein. Several studies have examined the possible effect ofAPO A2 on atherosclerosis incidence. Due to the role of inflammation in atherosclerosis, we aimed to determine the relationship betweenAPO A2 -265T/C polymorphism and inflammation as a risk factor in type 2 diabetes mellitus (T2DM) patients.Methods In total, 180 T2DM patients, with known
APO A2 -265T/C polymorphism, were recruited for this comparative study and were grouped equally based on their genotypes. Dietary intakes, anthropometric parameters, lipid profile, and inflammatory markers (i.e., pentraxin 3 [PTX3], high-sensitivity C-reactive protein [hs-CRP], and interleukin 18) were measured. The data were analyzed using an independentt -test, a chi-square test, and the analysis of covariance.Results After adjusting for confounding factors, in the entire study population and in the patients with or without obesity, the patients with the CC genotype showed higher hs-CRP (
P =0.001,P =0.008, andP =0.01, respectively) and lower PTX3 (P =0.01,P =0.03, andP =0.04, respectively) in comparison with the T allele carriers. In the patients with the CC genotype, no significant differences were observed in the inflammatory markers between the obese or non-obese patients. However, regarding the T allele carriers, the plasma hs-CRP level was significantly higher in the obese patients compared to the non-obese patients (P =0.01).Conclusion In the T2DM patients, the CC genotype could be considered as a risk factor and the T allele as a protective agent against inflammation, which the latter effect might be impaired by obesity. Our results confirmed the anti-atherogenic effect of
APO A2 , though more studies are required to establish this effect.-
Citations
Citations to this article as recorded by- Proteomic Profiling of Extracellular Vesicles Isolated from Plasma and Peritoneal Exudate in Mice Induced by Crotalus scutulatus scutulatus Crude Venom and Its Purified Cysteine-Rich Secretory Protein (Css-CRiSP)
Armando Reyes, Joseph D. Hatcher, Emelyn Salazar, Jacob Galan, Anton Iliuk, Elda E. Sanchez, Montamas Suntravat
Toxins.2023; 15(7): 434. CrossRef - ApoA2–256T > C polymorphism interacts with Healthy Eating Index, Dietary Quality Index-International and Dietary Phytochemical Index to affect biochemical markers among type 2 diabetic patients
Zahra Esmaeily, Gity Sotoudeh, Masoumeh Rafiee, Fariba Koohdani
British Journal of Nutrition.2022; 127(9): 1343. CrossRef - Interaction between Apo A-II –265T > C polymorphism and dietary total antioxidant capacity on some oxidative stress and inflammatory markers in patients with type 2 diabetes mellitus
Banafsheh Jafari Azad, Mehdi Yaseri, Elnaz Daneshzad, Fariba Koohdani
British Journal of Nutrition.2022; 128(1): 13. CrossRef - Deletion allele of Apo B gene is associated with higher inflammation, oxidative stress and dyslipidemia in obese type 2 diabetic patients: an analytical cross-sectional study
Nasim Mokhtary, Seyedeh Neda Mousavi, Gity Sotoudeh, Mostafa Qorbani, Maryam Dehghani, Fariba Koohdani
BMC Endocrine Disorders.2022;[Epub] CrossRef - Interaction between Apo A-II -265T>C polymorphism and dietary total antioxidant capacity on some anthropometric indices and serum lipid profile in patients with type 2 diabetes mellitus
Banafsheh Jafari Azad, Mehdi Yaseri, Elnaz Daneshzad, Fariba Koohdani
Journal of Nutritional Science.2021;[Epub] CrossRef - A personalised diet study: The interaction between ApoA2 −265T > C polymorphism and dietary inflammatory index on oxidative and inflammatory markers and lipid profile in patients with type 2 diabetes mellitus: A cross‐sectional study
Elmira Karimi, Pourya Tondkar, Gity Sotoudeh, Mostafa Qorbani, Masoumeh Rafiee, Fariba Koohdani
International Journal of Clinical Practice.2021;[Epub] CrossRef - Interaction between the dietary indices and PPAR‐γ Pro12Ala gene variants on cardiovascular risk factors in patients with type 2 diabetes mellitus
Faezeh Abaj, Gity Sotoudeh, Elmira Karimi, Masoumeh Rafiee, Fariba Koohdani
International Journal of Clinical Practice.2021;[Epub] CrossRef - A Genetic Score of Predisposition to Low-Grade Inflammation Associated with Obesity May Contribute to Discern Population at Risk for Metabolic Syndrome
Sebastià Galmés, Margalida Cifre, Andreu Palou, Paula Oliver, Francisca Serra
Nutrients.2019; 11(2): 298. CrossRef - Study of the relationship between APOA-II −265T>C polymorphism and HDL function in response to weight loss in overweight and obese type 2 diabetic patients
Masoumeh Moradi, Maryam Mahmoudi, Ahmad Saedisomeolia, Mohammad Ali Mansournia, Roxana Zahirihashemi, Fariba Koohdani
Clinical Nutrition.2018; 37(3): 965. CrossRef - Apolipoprotein A-II induces acute-phase response associated AA amyloidosis in mice through conformational changes of plasma lipoprotein structure
Mu Yang, Yingye Liu, Jian Dai, Lin Li, Xin Ding, Zhe Xu, Masayuki Mori, Hiroki Miyahara, Jinko Sawashita, Keiichi Higuchi
Scientific Reports.2018;[Epub] CrossRef - Prenatal Exposure to Lipopolysaccharide Induces PTX3 Expression and Results in Obesity in Mouse Offspring
Shugang Qin, Xin Chen, Meng Gao, Jianzhi Zhou, Xiaohui Li
Inflammation.2017; 40(6): 1847. CrossRef
- Proteomic Profiling of Extracellular Vesicles Isolated from Plasma and Peritoneal Exudate in Mice Induced by Crotalus scutulatus scutulatus Crude Venom and Its Purified Cysteine-Rich Secretory Protein (Css-CRiSP)
- Genetics
- Non-Association between rs7903146 and rs12255372 Polymorphisms in Transcription Factor 7-Like 2 Gene and Type 2 Diabetes Mellitus in Jahrom City, Iran
- Mohammad Pourahmadi, Saiedeh Erfanian, Malihe Moradzadeh, Abdolreza Sotoodeh Jahromi
- Diabetes Metab J. 2015;39(6):512-517. Published online November 13, 2015
- DOI: https://doi.org/10.4093/dmj.2015.39.6.512
- 3,105 View
- 32 Download
- 21 Web of Science
- 17 Crossref
-
Abstract
PDFPubReader
Background Transcription factor 7-like 2 (TCF7L2) is a transcription factor in the Wnt signaling pathway. High levels of TCF7L2 have been reported in most human tissues, including the heart, lung, brain, liver, kidney, placenta, adipose tissues, and pancreatic β-cells. The purpose of this study was to assess the association between TCF7L2 polymorphisms (rs12255372 and rs7903146) and type 2 diabetes mellitus in the city of Jahrom, Iran.
Methods This case-control study was conducted with 200 patients referred to Diabetes Clinics and 200 healthy subjects in Jahrom City. Biochemical characteristics were first determined. TCF7L2 rs1255372 and rs7903146 polymorphisms were then genotyped using the polymerase chain reaction-restriction fragment length polymorphism method.
Results T-allele frequencies of both single nucleotide polymorphisms (SNPs) were significantly higher in diabetic patients than in normal glucose-tolerant subjects (rs12255372: 20.3% vs. 14.5%; rs7903146: 28.5% vs. 22.25%). The rs12255372 (G/T) polymorphism analysis showed an odds ratio of 0.473 (95% confidence interval [CI], 0.170 to 1.314;
P =0.151) for the TT genotype and 0.646 (95% CI, 0.410 to 1.019;P =0.060) for the TG genotype, compared with the GG genotype. The rs7903146 (C/T) polymorphism odds ratios for TT and TC genotypes were 0.564 (95% CI, 0.280 to 1.135;P =0.109) and 0.751 (95% CI, 0.487 to 1.157;P =0.194) compared with the CC genotype, respectively.Conclusion The rs12255372 and rs7903146 SNPs of the TCF7L2 gene were not associated with insulin resistance in the evaluated population.
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Citations
Citations to this article as recorded by- Association between Transcription Factor 7-Like 2 Gene Polymorphisms rs7903146 and rs12255372 with the Risk of Diabetic Nephropathy among South Indian Population
Balaji Ramanathan, Kumaravel Velayutham
Chronicle of Diabetes Research and Practice.2024; 3(1): 8. CrossRef - Association between TCF7L2 polymorphism and type 2 diabetes mellitus susceptibility: a case–control study among the Bangladeshi population
Asma Salauddin, Kallyan Chakma, Md. Mahbub Hasan, Farhana Akter, Nowshad Asgar Chowdhury, Sumon Rahman Chowdhury, Adnan Mannan
Molecular Biology Reports.2023; 50(1): 609. CrossRef - Role of rs7903146 polymorphism and adropin serum level in patients with diabetes mellitus; a case–control study from Isfahan, Iran
Abbas-Ali Palizban, Abdol-Hamid Yazdani, Hamidreza Jahanbani-Ardakani
Archives of Physiology and Biochemistry.2022; 128(2): 378. CrossRef - PPARɣ2, aldose reductase, and TCF7L2 gene polymorphisms: relation to diabetes mellitus
Hadeel Ahmed Shawki, Ekbal M. Abo-hashem, Magdy M. Youssef, Maha Shahin, Rasha Elzehery
Journal of Diabetes & Metabolic Disorders.2022; 21(1): 241. CrossRef - Case-control study on the association between the GATA2 gene and premature myocardial infarction in the Iranian population
Peyman Izadpanah, Ehsan Khabbzi, Saiedeh Erfanian, Simin Jafaripour, Mohammad Shojaie
Herz.2021; 46(1): 71. CrossRef - Polymorphic genetic markers and how they are associated with clinical and metabolic indicators of type 2 diabetes mellitus in the Kazakh population
Valeriy V. Benberin, Tamara A. Vochshenkova, Gulshara Zh. Abildinova, Anna V. Borovikova, Almagul A. Nagimtayeva
Journal of Diabetes & Metabolic Disorders.2021; 20(1): 131. CrossRef - The role of transcription factor 7‐like 2 in metabolic disorders
Zhensheng Zhang, Li Xu, Xiao Xu
Obesity Reviews.2021;[Epub] CrossRef - Association of transcription factor 7-like 2 (rs7903146) gene polymorphism with diabetic retinopathy
Hadeel Ahmed Shawki, Ekbal M.Abo-Hashem, Magdy M. Youssef, Maha Shahin, Rasha Elzehery
Ophthalmic Genetics.2020; 41(5): 420. CrossRef - Association of SLC30A8, CDKAL1, TCF7L2 and HHEX Gene Polymorphisms with Type 2 Diabetes in the Population of North East India
A. Bhowmick, P. Sarkar, M. P. Baruah, D. Bodhini, V. Radha, V. Mohan, S. Banu
Cytology and Genetics.2020; 54(2): 165. CrossRef - Transcription Factor 7-Like-2 (TCF7L2) rs7903146 (C/T) Polymorphism in Patients with Type 2 Diabetes Mellitus
Ahmed Mohamed Bahaaeldin, Arig Aly Seif, Amira Ibrahim Hamed, Walaa Ahmed Yousry Kabiel
Dubai Diabetes and Endocrinology Journal.2020; 26(3): 112. CrossRef - The antileukemic effects of saffron (Crocus sativus L.) and its related molecular targets: A mini review
Maliheh Moradzadeh, Mohamad Reza Kalani, Amir Avan
Journal of Cellular Biochemistry.2019; 120(4): 4732. CrossRef - Association of transcription factor 7-like 2 (TCF7L2) gene polymorphism with type 2 diabetes mellitus in Chinese Korean ethnicity population
Kui-Chen Zhou, Hong-Wei Liu, Chen Wang, Yan-Jun Fu, Feng Jin
Medicine.2019; 98(5): e14288. CrossRef - Targeted deletion of Tcf7l2 in adipocytes promotes adipocyte hypertrophy and impaired glucose metabolism
Gisela Geoghegan, Judith Simcox, Marcus M. Seldin, Timothy J. Parnell, Chris Stubben, Steven Just, Lori Begaye, Aldons J. Lusis, Claudio J. Villanueva
Molecular Metabolism.2019; 24: 44. CrossRef - Association study of the rs46522 polymorphism in UBE2Z and rs7903146 polymorphism in TCF7L2 gene with T2DM in Arab population of Khuzestan province: case-control study
Sana Shafidelpour, Ali Mohammad Foroughmand, Merhrnoosh Zakerkish, Mahdi Pourmahdi Borujeni
Medical Journal of Tabriz University of Medical Sciences and Health Services.2019; 41(6): 59. CrossRef - Transcription factor 7-like 2 single nucleotide polymorphisms are associated with lipid profile in the Balinese
Sukma Oktavianthi, Made R. Saraswati, Ketut Suastika, Pande Dwipayana, Asri Sulfianti, Rahma F. Hayati, Hidayat Trimarsanto, Clarissa A. Febinia, Herawati Sudoyo, Safarina G. Malik
Molecular Biology Reports.2018; 45(5): 1135. CrossRef - Association of TCF7L2 mutation and atypical diabetes in a Uruguayan population
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World Journal of Diabetes.2018; 9(9): 157. CrossRef - Associations of TCF7L2 gene polymorphisms with the risk of diabetic nephropathy
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Medicine.2018; 97(40): e8388. CrossRef
- Association between Transcription Factor 7-Like 2 Gene Polymorphisms rs7903146 and rs12255372 with the Risk of Diabetic Nephropathy among South Indian Population
Review
- Resistin in Rodents and Humans
- Hyeong Kyu Park, Rexford S. Ahima
- Diabetes Metab J. 2013;37(6):404-414. Published online December 12, 2013
- DOI: https://doi.org/10.4093/dmj.2013.37.6.404
- 5,602 View
- 54 Download
- 122 Crossref
-
Abstract
PDFPubReader
Obesity is characterized by excess accumulation of lipids in adipose tissue and other organs, and chronic inflammation associated with insulin resistance and an increased risk of type 2 diabetes. Obesity, type 2 diabetes, and cardiovascular diseases are major health concerns. Resistin was first discovered as an adipose-secreted hormone (adipokine) linked to obesity and insulin resistance in rodents. Adipocyte-derived resistin is increased in obese rodents and strongly related to insulin resistance. However, in contrast to rodents, resistin is expressed and secreted from macrophages in humans and is increased in inflammatory conditions. Some studies have also suggested an association between increased resistin levels and insulin resistance, diabetes and cardiovascular disease. Genetic studies have provided additional evidence for a role of resistin in insulin resistance and inflammation. Resistin appears to mediate the pathogenesis of atherosclerosis by promoting endothelial dysfunction, vascular smooth muscle cell proliferation, arterial inflammation, and formation of foam cells. Indeed, resistin is predictive of atherosclerosis and poor clinical outcomes in patients with coronary artery disease and ischemic stroke. There is also growing evidence that elevated resistin is associated with the development of heart failure. This review will focus on the biology of resistin in rodents and humans, and evidence linking resistin with type 2 diabetes, atherosclerosis, and cardiovascular disease.
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Pediatric Reports.2022; 14(1): 86. CrossRef - High Serum Levels of Resistin is Associated With Acute Cerebral Infarction
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PLOS ONE.2022; 17(3): e0265241. CrossRef - Single-nucleotide polymorphisms as important risk factors of diabetes among Middle East population
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International Journal of Molecular Sciences.2022; 23(8): 4292. CrossRef - Hypoxia Increases the Potential for Neutrophil-mediated Endothelial Damage in Chronic Obstructive Pulmonary Disease
Katharine M. Lodge, Arlette Vassallo, Bin Liu, Merete Long, Zhen Tong, Paul R. Newby, Danya Agha-Jaffar, Koralia Paschalaki, Clara E. Green, Kylie B. R. Belchamber, Victoria C. Ridger, Robert A. Stockley, Elizabeth Sapey, Charlotte Summers, Andrew S. Cowb
American Journal of Respiratory and Critical Care Medicine.2022; 205(8): 903. CrossRef - The Role of the Adipokine Resistin in the Pathogenesis and Progression of Epithelial Ovarian Cancer
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Biomedicines.2022; 10(4): 920. CrossRef - Resistin Modulates Low-Density Lipoprotein Cholesterol Uptake in Human Placental Explants via PCSK9
Sonia Nava-Salazar, Arturo Flores-Pliego, Giovanni Pérez-Martínez, Sandra Parra-Hernández, America Vanoye-Carlo, Francisco Ibarguengoitia-Ochoa, Otilia Perichart-Perera, Enrique Reyes-Muñoz, Juan Mario Solis-Paredes, Salvador Espino y Sosa, Guadalupe Estr
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Mohammad Muzaffar Mir, Rashid Mir, Mushabab Ayed Abdullah Alghamdi, Javed Iqbal Wani, Zia Ul Sabah, Mohammed Jeelani, Vijaya Marakala, Shahzada Khalid Sohail, Mohamed O’haj, Muffarah Hamid Alharthi, Mohannad Mohammad S. Alamri
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Experimental Gerontology.2022; 164: 111823. CrossRef - Adipose Tissue Secretion Pattern Influences β-Cell Wellness in the Transition from Obesity to Type 2 Diabetes
Giuseppina Biondi, Nicola Marrano, Anna Borrelli, Martina Rella, Giuseppe Palma, Isabella Calderoni, Edoardo Siciliano, Pasquale Lops, Francesco Giorgino, Annalisa Natalicchio
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Biochemical Pharmacology.2022; 206: 115324. CrossRef - Evaluation of the Anti-Obesity Effect of Zeaxanthin and Exercise in HFD-Induced Obese Rats
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Nutrients.2021; 13(4): 1280. CrossRef - Resistin mitigates stemness and metabolic profile of human adipose-derived mesenchymal stem cells via insulin resistance
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Cytokine.2021; 138: 155374. CrossRef - Resistin is co-secreted with adiponectin in white mouse adipocytes
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Biochemical and Biophysical Research Communications.2021; 534: 707. CrossRef - Resistin: Potential biomarker and therapeutic target in atherosclerosis
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Frontiers in Cardiovascular Medicine.2020;[Epub] CrossRef - The possible role of endocrine dysfunction of adipose tissue in gestational diabetes mellitus
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The FEBS Journal.2020; 287(15): 3141. CrossRef - Adipokines: New Potential Therapeutic Target for Obesity and Metabolic, Rheumatic, and Cardiovascular Diseases
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Metabolism.2019; 95: 36. CrossRef - New Insights into Adipokines as Potential Biomarkers for Type-2 Diabetes Mellitus
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Phytomedicine.2018; 48: 70. CrossRef - Perivascular adipose tissue (PVAT) in atherosclerosis: a double-edged sword
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Disease Markers.2018; 2018: 1. CrossRef - Circulating fibroblast growth factor 21 in patients with liver cirrhosis
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Clinical and Experimental Medicine.2018; 18(1): 63. CrossRef - Association of Cord Blood Resistin with Neonatal Birth Weight and Gestational Age
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Inflammation Research.2017; 66(7): 611. CrossRef - Reference values for fasting serum resistin in healthy children and adolescents
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Clinica Chimica Acta.2017; 469: 161. CrossRef - Sarcopenic obesity or obese sarcopenia: A cross talk between age-associated adipose tissue and skeletal muscle inflammation as a main mechanism of the pathogenesis
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Neurochemical Research.2017; 42(10): 2949. CrossRef - Adipokines in Liver Cirrhosis
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The Korean Journal of Internal Medicine.2017; 32(2): 239. CrossRef - Translating the biology of adipokines in atherosclerosis and cardiovascular diseases: Gaps and open questions
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Archives of Endocrinology and Metabolism.2016; 60(2): 152. CrossRef - Sitagliptin decreases ventricular arrhythmias by attenuated glucose-dependent insulinotropic polypeptide (GIP)-dependent resistin signalling in infarcted rats
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Obésité.2016; 11(3): 181. CrossRef - Factors that promote macrophage homing to adipose tissue in metabolic syndrome
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Journal of Diabetes and its Complications.2016; 30(8): 1434. CrossRef - Uncovering Factors Related to Pancreatic Beta-Cell Function
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Clinical Kidney Journal.2016; 9(3): 359. CrossRef - Endocrine alterations from concentric vs. eccentric muscle actions: A brief review
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Metabolism.2015; 64(2): 190. CrossRef - Non-traditional cytokines: How catecholamines and adipokines influence macrophages in immunity, metabolism and the central nervous system
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Cytokine.2015; 72(2): 210. CrossRef - Local and serum levels of adipokines in patients with obesity after periodontal therapy: one‐year follow‐up
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Paediatric and Perinatal Epidemiology.2015; 29(4): 317. CrossRef - The effect of a preparation of minerals, vitamins and trace elements on the cardiac gene expression pattern in male diabetic rats
Márta Sárközy, Gergő Szűcs, Márton Pipicz, Ágnes Zvara, Katalin Éder, Veronika Fekete, Csilla Szűcs, Judit Bárkányi, Csaba Csonka, László G. Puskás, Csaba Kónya, Péter Ferdinandy, Tamás Csont
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BMC Genetics.2015;[Epub] CrossRef - INFLUENCE OF RESISTIN ON THE COURSE OF ISCHEMIC HEART DISEASE IN PATIENTS WITH TYPE 2 DIABETES MELLITUS
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Evidence-Based Complementary and Alternative Medicine.2015; 2015: 1. CrossRef - Evolution of the Vertebrate Resistin Gene Family
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PLOS ONE.2015; 10(6): e0130188. CrossRef - Obesity, adipokines and neuroinflammation
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Neuropharmacology.2015; 96: 124. CrossRef - Adipokines at the crossroad between obesity and cardiovascular disease
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- Hyun Chul Lee
- Diabetes Metab J. 2012;36(3):199-206. Published online June 14, 2012
- DOI: https://doi.org/10.4093/dmj.2012.36.3.199
- 3,605 View
- 31 Download
- 9 Crossref
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Abstract
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Postrenal transplantation diabetes mellitus (PTDM), or new-onset diabetes after organ transplantation, is an important chronic transplant-associated complication. Similar to type 2 diabetes, decreased insulin secretion and increased insulin resistance are important to the pathophysiologic mechanism behind the development of PTDM. However, β-cell dysfunction rather than insulin resistance seems to be a greater contributing factor in the development of PTDM. Increased age, family history of diabetes, ethnicity, genetic variation, obesity, and hepatitis C are partially accountable for an increased underlying risk of PTDM in renal allograft recipients. In addition, the use of and kinds of immunosuppressive agents are key transplant-associated risk factors. Recently, a number of genetic variants or polymorphisms susceptible to immunosuppressants have been reported to be associated with calcineurin inhibition-induced β-cell dysfunction. The identification of high risk factors of PTDM would help prevent PTDM and improve long-term patient outcomes by allowing for personalized immunosuppressant regimens and by managing cardiovascular risk factors.
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Sulwon Lecture 2009
- The Search for Genetic Risk Factors of Type 2 Diabetes Mellitus
- Kyong Soo Park
- Diabetes Metab J. 2011;35(1):12-22. Published online February 28, 2011
- DOI: https://doi.org/10.4093/dmj.2011.35.1.12
- 4,768 View
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- 23 Crossref
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Abstract
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Type 2 diabetes mellitus (T2DM) is caused by complex interplay between multiple genetic and environmental factors. The three major approaches used to identify the genetic susceptibility include candidate gene approach, familial linkage analysis and genome- wide association analysis. Recent advance in genome-wide association studies have greatly improved our understanding of the pathophysiology of T2DM. As of the end of 2010, there are more than 40 confirmed T2DM-associated genetic loci. Most of the T2DM susceptibility genes were implicated in decreased β-cell function. However, these genetic variations have a modest effect and their combination only explains less than 10% of the T2DM heritability. With the advent of the next-generation sequencing technology, we will soon identify rare variants of larger effect as well as causal variants. These advances in understanding the genetics of T2DM will lead to the development of new therapeutic and preventive strategies and individualized medicine.
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Original Articles
- R1467H Variants of Rho Guanine Nucleotide Exchange Factor 11 (
ARHGEF11 ) are Associated with Type 2 Diabetes Mellitus in Koreans - Qing Song Jin, So Hun Kim, Shan-Ji Piao, Hyun Ae Lim, Seung Youn Lee, Seong Bin Hong, Yong Seong Kim, Hun-Jae Lee, Moonsuk Nam
- Korean Diabetes J. 2010;34(6):368-373. Published online December 31, 2010
- DOI: https://doi.org/10.4093/kdj.2010.34.6.368
- 4,139 View
- 23 Download
- 11 Crossref
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Abstract
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Background The human Rho guanine nucleotide exchange factor 11 (
ARHGEF11 ) functions as an activator of Rho GTPases and is thought to influence insulin signaling. The R1467H variant ofARHGEF11 has been reported to be associated with susceptibility to type 2 diabetes mellitus (T2DM) in Western populations.Methods We investigated the effects of the R1467H variant on susceptibility to T2DM as well as related traits in a Korean population. We genotyped the R1467H (rs945508) of
ARHGEF11 in 689 unrelated T2DM patients and 249 non-diabetic individuals and compared the clinical and biochemical characteristics according to different alleles.Results The H allele was significantly more frequent in T2DM cases than in controls (
P = 0.037, 17.1% and 13.1%; respectively). H homozygocity was associated with a higher risk of T2DM compared to those with R/R or R/H genotype (odds ratio, 5.24; 95% confidence interval, 1.06 to 25.83;P = 0.042). The fasting plasma glucose, HbA1c, fasting insulin, HOMA2-IR and HOMA2-%β levels did not differ significantly between different genotypes.Conclusion Our study replicated associations of the
ARHGEF11 polymorphism with increased risk of T2DM in a Korean population and thus supports previous data implicating a potential role ofARHGEF11 in the etiology of T2DM. Further studies revealing the underlying mechanism for this association are needed.-
Citations
Citations to this article as recorded by- Epigenetic alteration of Rho guanine nucleotide exchange Factor 11 (ARHGEF11) in cord blood samples in macrosomia exposed to intrauterine hyperglycemia
Jie Yan, Rina Su, Wanyi Zhang, Yumei Wei, Chen Wang, Li Lin, Hui Feng, Huixia Yang
The Journal of Maternal-Fetal & Neonatal Medicine.2021; 34(3): 422. CrossRef -
Loss of
Arhgef11
in the Dahl Salt-Sensitive Rat Protects Against Hypertension-Induced Renal Injury
Ashley C. Johnson, Wenjie Wu, Esinam M. Attipoe, Jennifer M. Sasser, Erin B. Taylor, Kurt C. Showmaker, Patrick B. Kyle, Merry L. Lindsey, Michael R. Garrett
Hypertension.2020; 75(4): 1012. CrossRef - Transgenerational Obesity and Alteration of ARHGEF11 in the Rat Liver Induced by Intrauterine Hyperglycemia
Wanyi Zhang, Rina Su, Hui Feng, Li Lin, Chen Wang, Huixia Yang
Journal of Diabetes Research.2019; 2019: 1. CrossRef - ARHGEF11 affecting the placental insulin signaling pathway in fetal macrosomia of normal glucose tolerance pregnant women
Wanyi Zhang, Rina Su, Li Lin, Huixia Yang
Placenta.2018; 63: 7. CrossRef - Genetic variants and clinical relevance associated with gestational diabetes mellitus in Chinese women: a case-control study
Jie Yan, Rina Su, Deng Ao, Yan Wang, Haijun Wang, Huixia Yang
The Journal of Maternal-Fetal & Neonatal Medicine.2018; 31(16): 2115. CrossRef - Human Rho Guanine Nucleotide Exchange Factor 11 (ARHGEF11) Regulates Dendritic Morphogenesis
Yutaka Mizuki, Manabu Takaki, Shinji Sakamoto, Sojiro Okamoto, Makiko Kishimoto, Yuko Okahisa, Masahiko Itoh, Norihito Yamada
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Zhen Jia, Ashley C. Johnson, Xuexiang Wang, Zibiao Guo, Albert W. Dreisbach, Jack R. Lewin, Patrick B. Kyle, Michael R. Garrett, Maria Pia Rastaldi
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- Epigenetic alteration of Rho guanine nucleotide exchange Factor 11 (ARHGEF11) in cord blood samples in macrosomia exposed to intrauterine hyperglycemia
- Polymorphisms of the
Reg 1α Gene and Early Onset Type 2 Diabetes in the Korean Population - Bo Kyung Koo, Young Min Cho, Kuchan Kimm, Jong-Young Lee, Bermseok Oh, Byung Lae Park, Hyun Sub Cheong, Hyoung Doo Shin, Kyung Soo Ko, Sang Gyu Park, Hong Kyu Lee, Kyong Soo Park
- Korean Diabetes J. 2010;34(4):229-236. Published online August 31, 2010
- DOI: https://doi.org/10.4093/kdj.2010.34.4.229
- 3,532 View
- 23 Download
- 1 Crossref
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Abstract
PDFPubReader
Background The
Reg gene has been reported to be expressed in regenerating islets and Reg1 protein to be up-regulated at an early stage of diabetes in mice. As humanReg 1α is homologous with murineReg 1, we investigated whether common variants inReg 1α are associated with type 2 diabetes in the Korean population.Methods We sequenced the
Reg 1α gene to identify common polymorphisms using 24 Korean DNA samples. Of 11 polymorphisms found, five common ones (g.-385T>C [rs10165462], g.-36T>G [rs25689789], g.209G>T [rs2070707], g.1385C>G [novel], and g.2199G>A [novel]) were genotyped in 752 type 2 diabetic patients and 642 non-diabetic subjects.Results No polymorphism was associated with the risk of type 2 diabetes. However, g.-385C and g.2199A lowered the risk of early-onset type 2 diabetes, defined as a diagnosis in subjects whose age at diagnosis was 25 years or more but less than 40 years (odds ratio [OR], 0.721 [0.535 to 0.971] and 0.731 [0.546 to 0.977] for g.-385C and g.2199A, respectively) and g.1385G increased the risk of early-onset diabetes (OR, 1.398 [1.055 to 1.854]). Although adjusting for errors in multiple hypotheses-testing showed no statistically significant association between the three individual polymorphisms and early-onset diabetes, the haplotype
H1 , composed of g.-385C, g.1385C, and g.2199A, was associated with a reduced risk of early-onset diabetes (OR, 0.590 [0.396 to 0.877],P = 0.009).Conclusion Polymorphisms in the
Reg 1α were not found to be associated with overall susceptibility to type 2 diabetes, though some showed modest associations with early-onset type 2 diabetes in the Korean population.-
Citations
Citations to this article as recorded by- Glycemic Effects of Once-a-Day Rapid-Acting Insulin Analogue Addition on a Basal Insulin Analogue in Korean Subjects with Poorly Controlled Type 2 Diabetes Mellitus
Eun Yeong Choe, Yong-ho Lee, Byung-Wan Lee, Eun-Seok Kang, Bong Soo Cha, Hyun Chul Lee
Diabetes & Metabolism Journal.2012; 36(3): 230. CrossRef
- Glycemic Effects of Once-a-Day Rapid-Acting Insulin Analogue Addition on a Basal Insulin Analogue in Korean Subjects with Poorly Controlled Type 2 Diabetes Mellitus
- Genetic Association of Mitochondrial DNA Polymorphisms with Type 2 Diabetes Mellitus.
- Tae Su Han, Jee Hye Choi, Jina Park, Kwang Ho Lee, Ae Ja Park
- Korean Diabetes J. 2009;33(5):382-391. Published online October 1, 2009
- DOI: https://doi.org/10.4093/kdj.2009.33.5.382
- 1,815 View
- 25 Download
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Abstract
PDF
- BACKGROUND
Although many single nucleotide polymorphisms (SNPs) of mtDNA have been found to be associated with type 2 diabetes mellitus, the results of studies using different population samples and different methods are mixed. Therefore, we conducted a genetic association study of mtDNA SNPs and type 2 diabetes mellitus in a Korean sample and compared our results with those of studies conducted in other human populations. METHODS: A total of 298 blood samples from 147 type 2 diabetic patients and 151 normal controls were surveyed for SNPs via PCR directed sequencing. Sequencing analyses were performed using the SeqMan module of the DNASTAR program. The identified SNPs were compared to previously reported SNP lists on NCBI and V-mitoSNP. RESULTS: A total of 24 SNPs were identified in the MT-RNR2, MR-TL1 and MT-ND1 mtDNA genes in Korean type 2 diabetes mellitus patients and normal controls. The SNPs identified in the Korean sample were not closely associated with the type 2 diabetes mellitus phenotype, a significantly different result from those previously observed in European, Chinese and Japanese samples. Additionally, a haplotype and prevalence analysis could not detect any differences between the type 2 diabetes mellitus patients and normal controls. CONCLUSION: The 24 mtDNA SNPs were not associated with type 2 diabetes mellitus risk in our Korean sample. The results of the present study support the possibility that mtDNA SNPs have a differential effect on the risk of type 2 diabetes mellitus according to geographical origin.
- Matrix Metalloproteinase-3 Gene Polymorphism is Associated with Coronary Artery Calcification Scores in Patients with Type 2 Diabetes Mellitus.
- Sang Wook Kim, Eun Hee Cho
- Korean Diabetes J. 2009;33(2):113-123. Published online April 1, 2009
- DOI: https://doi.org/10.4093/kdj.2009.33.2.113
- 1,993 View
- 19 Download
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Abstract
PDF
- BACKGROUND
Matrix metalloproteinase-3 (MMP-3) is expressed in human coronary atherosclerotic lesions and is known to be involved in the degradation of plaque. This study examines the association of MMP-3 gene promoter 5A/6A and -709A>G polymorphisms with coronary artery calcium scores in type 2 diabetes patients. METHODS: The study comprises 140 type 2 diabetes patients aged 34~85 years, who showed no evidence of clinical cardiovascular disease before recruitment. Recruitment was based on patient's coronary artery calcium (CAC) scores and polymorphisms were identified. RESULTS: Multiple regression analysis showed that the CAC scores were significantly associated with age (P = 0.008), waist circumference (P = 0.03), duration of diabetes (P = 0.003) and the serum creatinine level (P = 0.012). MMP-3 5A/6A and -709A>G polymorphisms were not associated with CAC across all subjects. However, in the subgroup with a duration of diabetes over 10 years, MMP-3 -709A>G were significantly associated with CAC (P = 0.037) adjusted for age, body mass index, waist circumference and duration of diabetes. CONCLUSION: Our data suggest that the CAC scores in patients with type 2 diabetes were related with age, waist circumference, duration of diabetes and higher serum creatinine levels. MMP-3 polymorphisms with -709A>G are associated with high CAC in patients with a duration of diabetes over 10 years.
- An Association between 609 C --> T Polymorphism in NAD(P)H: Quinone Oxidoreductase 1 (NQO1) Gene and Blood Glucose Levels in Korean Population.
- Dohee Kim
- Korean Diabetes J. 2009;33(1):24-30. Published online February 1, 2009
- DOI: https://doi.org/10.4093/kdj.2009.33.1.24
- 2,107 View
- 22 Download
- 1 Crossref
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Abstract
PDF
- BACKGROUND
NAD(P)H: quinone oxidoreductase 1 (NQO1), which is an obligate two-electron reductase that utilizes NAD(P)H as an electron donor and is involved in the protection against oxidative stress, is likely involved in beta-cell destruction. We evaluated the frequency of the NQO1 polymorphism and its association with blood glucose levels. METHODS: Genotypes were determined using a polymerase chain reaction restriction fragment length polymorphism-based assay in 56 patients and 48 healthy subjects. Fasting blood glucose, insulin, and lipid profiles were measured and homeostasis model assessment (HOMA)-insulin resistance (IR) was calculated from fasting glucose and insulin levels in the healthy subjects. RESULTS: The genotype frequencies of NQO1 polymorphism were C/C (56.7%), C/T (42.3%), and T/T (1.0%). There were no associations between the NQO1 polymorphism and body mass index, blood pressure, lipid profile, HbA1c, postprandial glucose, and HOMA-IR. However, NQO1 mutants (C/T and T/T) showed weak but significantly higher fasting blood glucose levels compared with wild type (C/C). CONCLUSION: Our data suggest that NQO1 609 C --> T polymorphism may be associated with glucose metabolism. -
Citations
Citations to this article as recorded by- Association of Nuclear Factor-Erythroid 2-Related Factor 2, Thioredoxin Interacting Protein, and Heme Oxygenase-1 Gene Polymorphisms with Diabetes and Obesity in Mexican Patients
Angélica Saraí Jiménez-Osorio, Susana González-Reyes, Wylly Ramsés García-Niño, Hortensia Moreno-Macías, Martha Eunice Rodríguez-Arellano, Gilberto Vargas-Alarcón, Joaquín Zúñiga, Rodrigo Barquera, José Pedraza-Chaverri
Oxidative Medicine and Cellular Longevity.2016; 2016: 1. CrossRef
- Association of Nuclear Factor-Erythroid 2-Related Factor 2, Thioredoxin Interacting Protein, and Heme Oxygenase-1 Gene Polymorphisms with Diabetes and Obesity in Mexican Patients
- Association Study of the Peroxisome Proliferators-Activated Receptor gamma2 Pro12Ala Polymorphism with Diabetic Nephropathy.
- Kyu Ho Lee, Hee Seog Jeong, Khan Young Choi, Hyun Kim, Dal Sic Lee, Ji Young Kang, Hyun Jeong Jeon, Tae Keun Oh
- Korean Diabetes J. 2008;32(5):402-408. Published online October 1, 2008
- DOI: https://doi.org/10.4093/kdj.2008.32.5.402
- 1,913 View
- 16 Download
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Abstract
PDF
- BACKGROUND
Peroxisome proliferators-activated receptor gamma (PPARgamma) is a member of the nuclear hormone receptor superfamily of ligand-activated transcription factors and known to play a role in regulating the expression of numerous genes involved in lipid metabolism, metabolic syndrome, inflammation, and atherosclerosis. The PPARgamma2 Pro12Ala polymorphism has recently been shown to be associated with diabetic nephropathy. In this study, we evaluated the relationship between PPARgamma2 Pro12Ala polymorphism and type 2 diabetic nephropathy whose duration of diabetes was over 10 years. METHODS: We conducted a case-control study, which enrolled 367 patients with type 2 diabetes. Genotyping of PPARgamma2 Pro12Ala polymorphism was performed using polymerase chain reaction followed by digestion with Hae III restriction enzyme. RESULTS: The genotype or allele frequencies of PPARgamma2 Pro12Ala polymorphism were not significantly different in diabetic patients with or without diabetic nephropathy. The genotype frequencies in terms of diabetic retinopathy and macrovascular complications such as coronary artery disease or stroke were not different either. Interestingly, nephropathy patients with Ala/Pro genotype showed lower C-peptide levels than those of Pro/Pro genotype. CONCLUSION: Our results suggest that PPARgamma2 Pro12Ala polymorphism is not associated with diabetic nephropathy in type 2 diabetic patients.
- Association of the Polymorphisms in the PSMA6 (rs1048990) and PSMB5 (rs2230087) Genes with Type 2 Diabetes in Korean Subjects.
- Hee Kyoung Kim, Su Won Kim, Yun Jeong Doh, Sae Rom Kim, Mi Kyung Kim, Keun Gyu Park, Hye Soon Kim, Kyong Soo Park, Min Yoo, Jung Guk Kim, Bo Wan Kim, In Kyu Lee
- Korean Diabetes J. 2008;32(3):204-214. Published online June 1, 2008
- DOI: https://doi.org/10.4093/kdj.2008.32.3.204
- 2,212 View
- 23 Download
- 3 Crossref
-
Abstract
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- BACKGROUND
The 26S ubiquitin-proteasome system (UPS) is a principal proteolytic pathway of intracellular molecules regulating apoptosis, cell cycle, cell proliferation or differentiation, inflammation and etc. The recent study suggests that the rs1048990 (C/G) polymorphism of the proteasome subunit alpha type 6 (PSMA6) gene is associated with the increase of the risk of myocardial infarction by the dysregulation of IkappaB degradation. We hypothesized that 26S UPS is important in the development of insulin resistance and type 2 diabetes (T2DM) by controlling the degradation of IkappaB and insulin receptor substances as a substrate. We therefore investigated whether the rs1048990 (C/G) polymorphism of PSMA6 gene and the rs2230087 (G/A) polymorphism of proteasome subunit beta type 5 gene (PSMB5), that is chymotrypsin-like protease determining the rate of proteolysis, are associated with susceptibility to T2DM in Korean subjects. METHODS: We examined the polymorphisms of these genes in 309 diabetic subjects and 170 non-diabetic controls. The polymorphisms of rs1048990 (C/G) and rs2230087 (G/A) were genotyped by real-time PCR. RESULTS: The frequency of the G allele of rs1048990 (C/G) and the A allele of rs2230087 (G/A) polymorphisms was significantly higher in diabetic patients (28% and 13%) compared to that in controls (13% and 1%; P = 0.000 and P = 0.000, respectively). Logistic regression analysis of the rs1048990 (C/G) polymorphism showed that the odds ratio (OR) (adjusted for age, smoking, waist circumference, fasting plasma glucose, systolic blood pressure, HDL-C, triglyceride, and total cholesterol) was 3.93 (95% confidence interval [CI], 2.35-6.59; P = 0.000) for the G allele and 5.09 (95% CI, 2.71-9.57; P = 0.000) for CG and GG genotype when compared with the CC genotype. Logistic regression analysis of the rs2230087 (G/A) polymorphism showed that the adjusted OR was 5.70 (95% CI, 1.63-19.98; P = 0.007) for the A allele and 6.08 (95% CI, 1.66-22.29; P = 0.006) for GA and AA genotype when compared with the GG genotype. In multiple logistic regression analysis with T2DM as the independent Variable rs1048990 (C/G) and rs2230087 (G/A) polymorphisms were the predictor for T2DM. CONCLUSION: We suggest that the G allele of rs1048990 (C/G) polymorphism and the A allele of rs2230087 (G/A) polymorphism may be genetic risk factor to type 2 diabetes mellitus in Korean subjects. -
Citations
Citations to this article as recorded by- Ubiquitin-proteasome system in diabetic retinopathy
Zane Svikle, Beate Peterfelde, Nikolajs Sjakste, Kristine Baumane, Rasa Verkauskiene, Chi-Juei Jeng, Jelizaveta Sokolovska
PeerJ.2022; 10: e13715. CrossRef - 1,4‐Dihydropyridine derivatives without Ca2+‐antagonist activity up‐regulate Psma6 mRNA expression in kidneys of intact and diabetic rats
Kristīne Ošiņa, Evita Rostoka, Jelizaveta Sokolovska, Natalia Paramonova, Egils Bisenieks, Gunars Duburs, Nikolajs Sjakste, Tatjana Sjakste
Cell Biochemistry and Function.2016; 34(1): 3. CrossRef - Genetic variations in the PSMA3, PSMA6 and PSMC6 genes are associated with type 1 diabetes in Latvians and with expression level of number of UPS-related and T1DM-susceptible genes in HapMap individuals
Tatjana Sjakste, Natalia Paramonova, Kristine Osina, Kristine Dokane, Jelizaveta Sokolovska, Nikolajs Sjakste
Molecular Genetics and Genomics.2016; 291(2): 891. CrossRef
- Ubiquitin-proteasome system in diabetic retinopathy
- Association between Apolipoprotein E Polymorphism and Type 2 Diabetes in Subjects Aged 65 or Over.
- You Jin Lee, Hak Chul Jang, Eun Hye Kim, Hye Jin Kim, Seok Bum Lee, Sung Hee Choi, Soo Lim, Kyoung Un Park, Young Joo Park, Ki Woong Kim
- Korean Diabetes J. 2008;32(1):30-37. Published online February 1, 2008
- DOI: https://doi.org/10.4093/kdj.2008.32.1.30
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Abstract
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- BACKGROUND
Increased prevalence of diabetes in recent years is linked with increased cardiovascular morbidity and mortality. Apolipoprotein E (apo E) polymorphism is well known to be related to hyperlipidemia and coronary heart disease, but only a few studies investigated the association between apo E polymorphism and diabetes or insulin resistance. In Korea, two studies with relatively small subjects reported controversial results. Therefore, we investigated the association between apo E polymorphism and diabetes in elderly community population. METHODS: 982 elderly people aged 65 or over in Seongnam city were enrolled. We measured anthropometric variables and blood pressure and performed biochemical tests including fasting glucose, fasting insulin, HbA1c, and lipid profiles. Apo E polymorphism was determined by PCR-RFLP method. RESULTS: Frequencies of apo E isoforms and alleles were similar to those of other reports. Subjects with e4 allele had significantly higher total and LDL-cholesterol levels. However, there were no differences in cholesterol levels between normal subjects and diabetes. Diabetes was not related to apo E polymorphism. CONCLUSION: In Korean aged 65 or over, subjects with diabetes didn't have increased total or LDL-cholesterol, triglyceride, and decreased HDL-cholesterol levels. Diabetes and apo E polymorphism were not related. -
Citations
Citations to this article as recorded by- Association of APOE genotype with lipid profiles and type 2 diabetes mellitus in a Korean population
Jung Yeon Seo, Byeong Ju Youn, Hyun Sub Cheong, Hyoung Doo Shin
Genes & Genomics.2021; 43(7): 725. CrossRef - Sarcopenia, Frailty, and Diabetes in Older Adults
Hak Chul Jang
Diabetes & Metabolism Journal.2016; 40(3): 182. CrossRef
- Association of APOE genotype with lipid profiles and type 2 diabetes mellitus in a Korean population
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