Table 1Clinical data of the study subjects
![dmj-39-512-i001.jpg]()
Variable |
NGT subjects |
Type 2 diabetic subjects |
P value |
Sex, male/female |
71/129 (35.5/64.5) |
63/137 (31.5/68.5) |
0.397 |
Age, yr |
11.1±51.6 |
13.5±52.7 |
0.199 |
BMI, kg/m2
|
11.3±27 |
16.2±28.4 |
0.031 |
FBG, mg/dL |
9.3±93.5 |
70±159.6 |
<0.001 |
Total cholesterol, mg/dL |
44.4±197.6 |
56.6±206.1 |
0.205 |
HDL-C, mg/dL |
8.9±42.8 |
25.5±45.8 |
0.299 |
LDL-C, mg/dL |
33.1±125.1 |
42.8±122.6 |
0.545 |
TG, mg/dL |
77.9±150.9 |
122.7±186.2 |
0.001 |
Table 2Genotype frequencies of rs7903146 and rs12255372 polymorphisms in type 2 diabetic patients (n=200) and control subjects (n=200)
![dmj-39-512-i002.jpg]()
Genotype |
NGT subjects (n=200) |
Type 2 diabetic subjects (n=200) |
Odds ratio |
P value |
rs12255372 (G/T) |
|
|
|
|
GG |
148 (75) |
130 (65) |
Reference |
Reference |
TG |
46 (22) |
59 (29.5) |
0.646 (0.410-1.019) |
0.060 |
TT |
6 (3) |
11 (6.5) |
0.473 (0.170-1.314) |
0.151 |
TT+TG |
52 (24) |
70 (35) |
0.619 (0.402-0.954) |
0.038 |
GG |
148 (76) |
130 (65) |
|
|
Frequency of T allele, % |
14.5 |
20.3 |
0.668 (0.461-0.967) |
0.033 |
rs7903146 (C/T) |
|
|
|
|
CC |
126 (63) |
109 (54.5) |
Reference |
|
TC |
59 (29.5) |
68 (34) |
0.751 (0.487-1.157) |
0.194 |
TT |
15 (7.5) |
23 (11.5) |
0.564 (0.280-1.135) |
0.109 |
TT+TC |
74 (37) |
91 (45.5) |
0.703 (0.472-1.049) |
0.104 |
CC |
126 (63) |
109 (54.5) |
|
|
Frequency of T allele, % |
22.25 |
28.5 |
0.718 (0.521-0.989) |
0.043 |
Table 3Biochemical variables and genotypes
![dmj-39-512-i003.jpg]()
Variable |
rs12255372 (G/T) |
rs7903146 (C/T) |
TT+TG |
GG |
P value |
TT+TC |
CC |
P value |
BMI, kg/m2
|
28.5±1.9 |
27.3±0.59 |
0.478 |
27.7±0.9 |
27.7±0.9 |
0.991 |
Fasting glucose, mg/dL |
129.4±5.5 |
125.3±3.6 |
0.536 |
120.6±3.9 |
131.1±4.2 |
0.086 |
Total cholesterol, mg/dL |
212.2±4.7 |
197.4±2.9 |
0.008 |
194.1±4.0 |
204.2±3.2 |
0.050 |
HDL-C, mg/dL |
46.3±1.2 |
43.4±1.3 |
0.175 |
45.4±2.7 |
44.2±0.7 |
0.611 |
LDL-C, mg/dL |
128.2±3.4 |
121.9±2.3 |
0.138 |
117.2±2.9 |
126.1±2.5 |
0.021 |
TG, mg/dL |
174.1±10.5 |
166.2±5.9 |
0.489 |
158.7±7.2 |
176.1±7.1 |
0.101 |