Table 1Baseline characteristics of the patients enrolled in the study and according to the presence of subjective neuropathic symptoms
Characteristic |
Total (n=136) |
Symptoma (n=48) |
No symptomb (n=88) |
P value |
Male sex |
68 (50.0) |
18 (37.5) |
50 (56.8) |
0.048 |
Age, yr |
59.4±12.2 |
59.9±11.6 |
59.2±12.5 |
0.751 |
Duration of T2DM, yr |
10.5±9.3 |
11.6±9.9 |
9.9±8.9 |
0.306 |
HbA1c, % |
8.0±2.0 |
8.1±1.7 |
7.9±2.1 |
0.639 |
eGFRc, mL/min/1.73 m2
|
90.09±11.87 |
89.38±11.81 |
90.49±11.95 |
0.605 |
Hypertensiond
|
85 (62.5) |
33 (68.8) |
52 (59.1) |
0.177 |
Dyslipidemiae
|
51 (37.5) |
21 (43.8) |
30 (34.1) |
0.177 |
Vascular diseasef
|
20 (14.7) |
9 (18.8) |
11 (12.5) |
0.230 |
Mode of treatment |
|
|
|
0.252 |
OADg
|
113 (83.1) |
38 (79.2) |
75 (85.2) |
OAD+insulinh
|
23 (16.9) |
10 (20.8) |
13 (14.8) |
Table 2Results of all methods according to the presence of subjective neuropathic symptoms
Methods |
Patients with symptomsa
|
Patients with no symptomb
|
Abnormal |
Normal |
Abnormal |
Normal |
Tests |
|
|
|
|
Pinprick test |
6 (12.5) |
42 (87.5) |
5 (5.7) |
83 (94.3) |
SWMEd
|
9 (18.8) |
39 (81.2) |
5 (5.7) |
83 (94.3) |
Tuning-forkc,e
|
28 (58.3) |
20 (41.7) |
25 (28.4) |
63 (71.6) |
Ankle reflexe
|
39 (81.3) |
9 (18.7) |
48 (54.5) |
40 (45.5) |
Any of above 4d
|
42 (87.5) |
6 (12.5) |
59 (67.0) |
29 (33.0) |
Pinprick test+Tuning-forkf
|
29 (60.4) |
19 (39.6) |
25 (28.4) |
63 (71.6) |
Pinprick test+Ankle reflexe
|
39 (81.3) |
9 (18.7) |
50 (56.8) |
38 (43.2) |
SWME+Tuning-forke
|
29 (60.4) |
19 (39.6) |
25 (28.4) |
63 (71.6) |
SWME+Ankle reflexe
|
39 (81.3) |
9 (18.7) |
49 (55.7) |
39 (44.3) |
Tuning-fork+Ankle reflexd
|
42 (87.5) |
6 (12.5) |
59 (67.0) |
29 (33.0) |
Questionnaires |
|
|
|
|
MNSI questionnairef
|
37 (77.1) |
11 (22.9) |
8 (9.1) |
80 (90.9) |
Total Symptom Scoref
|
20 (41.7) |
28 (58.3) |
2 (2.3) |
86 (97.7) |
Any of above 2f
|
37 (77.1) |
11 (22.9) |
9 (10.2) |
79 (89.8) |
All 6 abovef
|
47 (97.9) |
1 (2.1) |
62 (70.5) |
26 (29.5) |