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Effect of Treadmill Exercise on Interleukin-15 Expression and Glucose Tolerance in Zucker Diabetic Fatty Rats
Hee-Jae Kim, Jae Young Park, Seung Lyul Oh, Yong-An Kim, Byunghun So, Je Kyung Seong, Wook Song
Diabetes Metab J. 2013;37(5):358-364.   Published online October 17, 2013
DOI: https://doi.org/10.4093/dmj.2013.37.5.358
  • 4,193 View
  • 34 Download
  • 25 Crossref
AbstractAbstract PDFPubReader   
Background

Interleukin-15 (IL-15), a well-known myokine, is highly expressed in skeletal muscle and is involved in muscle-fat crosstalk. Recently, a role of skeletal muscle-derived IL-15 in the improvement of glucose homeostasis and insulin sensitivity has been proposed. However, little is known regarding the influence of endurance training on IL-15 expression in type 2 diabetic skeletal muscles. We investigated the effect of endurance exercise training on glucose tolerance and IL-15 expression in skeletal muscles using type 2 diabetic animal models.

Methods

Male Zucker diabetic fatty (ZDF) and ZDF lean control (ZLC) rats were randomly divided into three groups: sedentary ZLC, sedentary ZDF (ZDF-Con), and exercised ZDF (ZDF-Ex). The ZDF-Ex rats were forced to run a motor-driven treadmill for 60 minutes once a day 5 times per week for 12 weeks. Intraperitoneal glucose tolerance test (IPGTT) was performed after 12 weeks. Expression of IL-15 was measured using ELISA in extracted soleus (SOL) and gastrocnemius medial muscles.

Results

After 12 weeks of treadmill training, reduction of body weight was observed in ZDF-Ex compared to ZDF-Con rats. Glucose tolerance using IPGTT in diabetic rats was significantly improved in ZDF-Ex rats. Furthermore, the expression of IL-15 was significantly increased (P<0.01) only in the SOL of ZDF-Ex rats compared to ZDF-Con. Additionally, IL-15 expression in SOL muscles was negatively correlated with change of body weight (R=-0.424, P=0.04).

Conclusion

The present study results suggest that 12 weeks of progressive endurance training significantly improved glucose tolerance with concomitant increase of IL-15 expression in SOL muscles of type 2 diabetic rats.

Citations

Citations to this article as recorded by  
  • Beyond muscles: Investigating immunoregulatory myokines in acute resistance exercise – A systematic review and meta‐analysis
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    Nutrition & Diabetes.2024;[Epub]     CrossRef
  • Exercise‐regulated white adipocyte differentitation: An insight into its role and mechanism
    Linjing Yan, Liang Guo
    Journal of Cellular Physiology.2023; 238(8): 1670.     CrossRef
  • Effects of short-term physical training on the interleukin-15 signalling pathway and glucose tolerance in aged rats
    Luciele Guerra Minuzzi, Luciana Renata da Conceição, Vitor Rosetto Muñoz, Renan Fudoli Lins Vieira, Rafael Calais Gaspar, Adelino S.R. da Silva, Dennys Esper Cintra, Leandro Pereira de Moura, Eduardo Rochete Ropelle, Ana Maria Teixeira, José Rodrigo Pauli
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    Nathália C. D. Macedo, Isabela L. Iessi, Franciane Q. Gallego, Aline O. Netto, Yuri K. Sinzato, Gustavo T. Volpato, Elena Zambrano, Débora C. Damasceno
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    Healthcare.2020; 8(4): 378.     CrossRef
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    Taku Fujimoto, Ken Sugimoto, Toshimasa Takahashi, Yukiko Yasunobe, Keyu Xie, Minoru Tanaka, Yuri Ohnishi, Shino Yoshida, Hitomi Kurinami, Hiroshi Akasaka, Yoichi Takami, Yasushi Takeya, Koichi Yamamoto, Hiromi Rakugi
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  • IL-15 expression increased in response to treadmill running and inhibited endoplasmic reticulum stress in skeletal muscle in rats
    Hong-Tao Yang, Li-Jie Luo, Wen-Jia Chen, Lei Zhao, Chao-Shu Tang, Yong-Fen Qi, Jing Zhang
    Endocrine.2015; 48(1): 152.     CrossRef
  • Time course of IL-15 expression after acute resistance exercise in trained rats: effect of diabetes and skeletal muscle phenotype
    Mahdieh Molanouri Shamsi, Zuhair Mohammad Hassan, LeBris S. Quinn, Reza Gharakhanlou, Leila Baghersad, Mehdi Mahdavi
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    Milène Catoire, Sander Kersten
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    Grant O'Connell, Ge Guo, Janelle Stricker, LeBris S. Quinn, Averil Ma, Emidio E. Pistilli
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  • Exercise-induced myokines in health and metabolic diseases
    Byunghun So, Hee-Jae Kim, Jinsoo Kim, Wook Song
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Exercise Treadmill Test in Detecting Asymptomatic Coronary Artery Disease in Type 2 Diabetes Mellitus
Mee Kyoung Kim, Ki Hyun Baek, Ki Ho Song, Hyuk Sang Kwon, Jung Min Lee, Moo Il Kang, Kun Ho Yoon, Bong Yun Cha, Ho Young Son, Kwang Woo Lee
Diabetes Metab J. 2011;35(1):34-40.   Published online February 28, 2011
DOI: https://doi.org/10.4093/dmj.2011.35.1.34
  • 25,395 View
  • 41 Download
  • 15 Crossref
AbstractAbstract PDFPubReader   
Background

The present study was designed to develop criteria for screening patients with type 2 diabetes mellitus (T2DM) for asymptomatic coronary artery disease (CAD).

Methods

A total of 213 patients with T2DM without typical angina or chest pain were studied between 2002 and 2007. We also evaluated 53 patients with T2DM who had reported chest discomfort using an exercise treadmill test (ETT).

Results

Thirty-one of the 213 asymptomatic patients had positive ETT results. We performed coronary angiography on 23 of the 31 patients with a positive ETT and found that 11 of them had significant coronary stenosis. The main differences between the patients with significant stenosis and those with a negative ETT were age (63.1±9.4 vs. 53.7±10.1 years, P=0.008) and duration of diabetes (16.0±7.5 vs. 5.5±5.7 years, P<0.001). The positive predictive value (PPV) of the ETT was calculated to be 47.8%. The PPV of the ETT increased to 87.5% in elderly patients (≥60 years) with a long duration of diabetes (≥10 years). The latter value is similar to that of patients with T2DM who presented with chest discomfort or exertional dyspnea. The PPV of the ETT in symptomatic patients was 76.9%.

Conclusion

In the interest of cost-effectiveness, screening for asymptomatic CAD could be limited to elderly patients with a duration of diabetes ≥10 years.

Citations

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