Diabetes & Metabolism Journal

Original Articles

Effect of Treadmill Exercise on Interleukin-15 Expression and Glucose Tolerance in Zucker Diabetic Fatty Rats: Hee-Jae Kim, Jae Young Park, Seung Lyul Oh, Yong-An Kim, Byunghun So, Je Kyung Seong, Wook Song; Diabetes Metab J. 2013;37(5):358-364. Published online October 17, 2013; DOI: https://doi.org/10.4093/dmj.2013.37.5.358

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Background

Interleukin-15 (IL-15), a well-known myokine, is highly expressed in skeletal muscle and is involved in muscle-fat crosstalk. Recently, a role of skeletal muscle-derived IL-15 in the improvement of glucose homeostasis and insulin sensitivity has been proposed. However, little is known regarding the influence of endurance training on IL-15 expression in type 2 diabetic skeletal muscles. We investigated the effect of endurance exercise training on glucose tolerance and IL-15 expression in skeletal muscles using type 2 diabetic animal models.

Methods

Male Zucker diabetic fatty (ZDF) and ZDF lean control (ZLC) rats were randomly divided into three groups: sedentary ZLC, sedentary ZDF (ZDF-Con), and exercised ZDF (ZDF-Ex). The ZDF-Ex rats were forced to run a motor-driven treadmill for 60 minutes once a day 5 times per week for 12 weeks. Intraperitoneal glucose tolerance test (IPGTT) was performed after 12 weeks. Expression of IL-15 was measured using ELISA in extracted soleus (SOL) and gastrocnemius medial muscles.

Results

After 12 weeks of treadmill training, reduction of body weight was observed in ZDF-Ex compared to ZDF-Con rats. Glucose tolerance using IPGTT in diabetic rats was significantly improved in ZDF-Ex rats. Furthermore, the expression of IL-15 was significantly increased (P<0.01) only in the SOL of ZDF-Ex rats compared to ZDF-Con. Additionally, IL-15 expression in SOL muscles was negatively correlated with change of body weight (R=-0.424, P=0.04).

Conclusion

The present study results suggest that 12 weeks of progressive endurance training significantly improved glucose tolerance with concomitant increase of IL-15 expression in SOL muscles of type 2 diabetic rats.

Citations

Citations to this article as recorded by

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Miriam Ringleb, Florian Javelle, Simon Haunhorst, Wilhelm Bloch, Lena Fennen, Sabine Baumgart, Sebastian Drube, Philipp A. Reuken, Mathias W. Pletz, Heiko Wagner, Holger H. W. Gabriel, Christian Puta
The FASEB Journal.2024;[Epub] CrossRef
Exercise‐regulated white adipocyte differentitation: An insight into its role and mechanism
Linjing Yan, Liang Guo
Journal of Cellular Physiology.2023; 238(8): 1670. CrossRef
Effects of short-term physical training on the interleukin-15 signalling pathway and glucose tolerance in aged rats
Luciele Guerra Minuzzi, Luciana Renata da Conceição, Vitor Rosetto Muñoz, Renan Fudoli Lins Vieira, Rafael Calais Gaspar, Adelino S.R. da Silva, Dennys Esper Cintra, Leandro Pereira de Moura, Eduardo Rochete Ropelle, Ana Maria Teixeira, José Rodrigo Pauli
Cytokine.2021; 137: 155306. CrossRef
Swimming Program on Mildly Diabetic Rats in Pregnancy
Nathália C. D. Macedo, Isabela L. Iessi, Franciane Q. Gallego, Aline O. Netto, Yuri K. Sinzato, Gustavo T. Volpato, Elena Zambrano, Débora C. Damasceno
Reproductive Sciences.2021; 28(8): 2223. CrossRef
Exercise training and de-training effects on serum leptin and TNF-α in high fat induced diabetic rats
Hamideh Dinari Ghozhdi, Ali Heidarianpour, Maryam Keshvari, Hassan Tavassoli
Diabetology & Metabolic Syndrome.2021;[Epub] CrossRef
Exercise-Induced Myokines can Explain the Importance of Physical Activity in the Elderly: An Overview
Jenny Hyosun Kwon, Kyoung Min Moon, Kyueng-Whan Min
Healthcare.2020; 8(4): 378. CrossRef
Myokine/Adipokine Response to “Aerobic” Exercise: Is It Just a Matter of Exercise Load?
Zihong He, Ye Tian, Pedro L. Valenzuela, Chuanye Huang, Jiexiu Zhao, Ping Hong, Zilin He, Shuhui Yin, Alejandro Lucia
Frontiers in Physiology.2019;[Epub] CrossRef
Overexpression of Interleukin-15 exhibits improved glucose tolerance and promotes GLUT4 translocation via AMP-Activated protein kinase pathway in skeletal muscle
Taku Fujimoto, Ken Sugimoto, Toshimasa Takahashi, Yukiko Yasunobe, Keyu Xie, Minoru Tanaka, Yuri Ohnishi, Shino Yoshida, Hitomi Kurinami, Hiroshi Akasaka, Yoichi Takami, Yasushi Takeya, Koichi Yamamoto, Hiromi Rakugi
Biochemical and Biophysical Research Communications.2019; 509(4): 994. CrossRef
Insights from Exercise-induced Cardioprotection-from Clinical Application to Basic Research
Hao Jiang, Beijian Zhang, Daile Jia, Wenlong Yang, Aijun Sun, Junbo Ge
Current Pharmaceutical Design.2019; 25(35): 3751. CrossRef
Myokine Response to High-Intensity Interval vs. Resistance Exercise: An Individual Approach
Zihong He, Ye Tian, Pedro L. Valenzuela, Chuanye Huang, Jiexiu Zhao, Ping Hong, Zilin He, Shuhui Yin, Alejandro Lucia
Frontiers in Physiology.2018;[Epub] CrossRef
A systematic review of “myokines and metabolic regulation”
Henry H. León-Ariza, María P. Mendoza-Navarrete, María I. Maldonado-Arango, Daniel A. Botero-Rosas
Apunts. Medicina de l'Esport.2018; 53(200): 155. CrossRef
Exercise benefits in cardiovascular disease: beyond attenuation of traditional risk factors
Carmen Fiuza-Luces, Alejandro Santos-Lozano, Michael Joyner, Pedro Carrera-Bastos, Oscar Picazo, José L. Zugaza, Mikel Izquierdo, Luis M. Ruilope, Alejandro Lucia
Nature Reviews Cardiology.2018; 15(12): 731. CrossRef
Effects of 8 Weeks Resistance Exercise on GSH, SOD, TBARS Activities and GLUT2 mRNA Expression of Pancreas in OLETF Rats
Min-Ki Lee, Jin-Hwan Yoon
The Korean Journal of Physical Education.2017; 56(3): 551. CrossRef
Exercise effects on perivascular adipose tissue: endocrine and paracrine determinants of vascular function
B C S Boa, J S Yudkin, V W M van Hinsbergh, E Bouskela, E C Eringa
British Journal of Pharmacology.2017; 174(20): 3466. CrossRef
IL15RA is required for osteoblast function and bone mineralization
Emanuele Loro, Girish Ramaswamy, Abhishek Chandra, Wei-Ju Tseng, Manoj K. Mishra, Eileen M. Shore, Tejvir S. Khurana
Bone.2017; 103: 20. CrossRef
Interleukin‐15 in obesity and metabolic dysfunction: current understanding and future perspectives
Y. Duan, F. Li, W. Wang, Q. Guo, C. Wen, Y. Li, Y. Yin
Obesity Reviews.2017; 18(10): 1147. CrossRef
Effects of interval aerobic training combined with strength exercise on body composition, glycaemic and lipid profile and aerobic capacity of obese rats
Irene Coll-Risco, Virginia A. Aparicio, Elena Nebot, Daniel Camiletti-Moirón, Rosario Martínez, Garyfallia Kapravelou, María López-Jurado, Jesús M. Porres, Pilar Aranda
Journal of Sports Sciences.2016; 34(15): 1452. CrossRef
Exercise-induced alterations in pancreatic oxidative stress and mitochondrial function in type 2 diabetic Goto-Kakizaki rats
Haider Raza, Annie John, Jasmin Shafarin, Frank C. Howarth
Physiological Reports.2016; 4(8): e12751. CrossRef
Interval aerobic training combined with strength-endurance exercise improves metabolic markers beyond caloric restriction in Zucker rats
V.A. Aparicio, I. Coll-Risco, D. Camiletti-Moirón, E. Nebot, R. Martínez, M. López-Jurado, P. Aranda
Nutrition, Metabolism and Cardiovascular Diseases.2016; 26(8): 713. CrossRef
IL-15 expression increased in response to treadmill running and inhibited endoplasmic reticulum stress in skeletal muscle in rats
Hong-Tao Yang, Li-Jie Luo, Wen-Jia Chen, Lei Zhao, Chao-Shu Tang, Yong-Fen Qi, Jing Zhang
Endocrine.2015; 48(1): 152. CrossRef
Time course of IL-15 expression after acute resistance exercise in trained rats: effect of diabetes and skeletal muscle phenotype
Mahdieh Molanouri Shamsi, Zuhair Mohammad Hassan, LeBris S. Quinn, Reza Gharakhanlou, Leila Baghersad, Mehdi Mahdavi
Endocrine.2015; 49(2): 396. CrossRef
The search for exercise factors in humans
Milène Catoire, Sander Kersten
The FASEB Journal.2015; 29(5): 1615. CrossRef
Muscle-specific deletion of exons 2 and 3 of theIL15RAgene in mice: effects on contractile properties of fast and slow muscles
Grant O'Connell, Ge Guo, Janelle Stricker, LeBris S. Quinn, Averil Ma, Emidio E. Pistilli
Journal of Applied Physiology.2015; 118(4): 437. CrossRef
Exercise-induced myokines in health and metabolic diseases
Byunghun So, Hee-Jae Kim, Jinsoo Kim, Wook Song
Integrative Medicine Research.2014; 3(4): 172. CrossRef

Exercise Treadmill Test in Detecting Asymptomatic Coronary Artery Disease in Type 2 Diabetes Mellitus: Mee Kyoung Kim, Ki Hyun Baek, Ki Ho Song, Hyuk Sang Kwon, Jung Min Lee, Moo Il Kang, Kun Ho Yoon, Bong Yun Cha, Ho Young Son, Kwang Woo Lee; Diabetes Metab J. 2011;35(1):34-40. Published online February 28, 2011; DOI: https://doi.org/10.4093/dmj.2011.35.1.34

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38 Download
15 Crossref

Abstract PDF PubReader

Background

The present study was designed to develop criteria for screening patients with type 2 diabetes mellitus (T2DM) for asymptomatic coronary artery disease (CAD).

Methods

A total of 213 patients with T2DM without typical angina or chest pain were studied between 2002 and 2007. We also evaluated 53 patients with T2DM who had reported chest discomfort using an exercise treadmill test (ETT).

Results

Thirty-one of the 213 asymptomatic patients had positive ETT results. We performed coronary angiography on 23 of the 31 patients with a positive ETT and found that 11 of them had significant coronary stenosis. The main differences between the patients with significant stenosis and those with a negative ETT were age (63.1±9.4 vs. 53.7±10.1 years, P=0.008) and duration of diabetes (16.0±7.5 vs. 5.5±5.7 years, P<0.001). The positive predictive value (PPV) of the ETT was calculated to be 47.8%. The PPV of the ETT increased to 87.5% in elderly patients (≥60 years) with a long duration of diabetes (≥10 years). The latter value is similar to that of patients with T2DM who presented with chest discomfort or exertional dyspnea. The PPV of the ETT in symptomatic patients was 76.9%.

Conclusion

In the interest of cost-effectiveness, screening for asymptomatic CAD could be limited to elderly patients with a duration of diabetes ≥10 years.

Citations

Citations to this article as recorded by

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Muhammad Khalil, Muhammad Shafique Arshad, Asma Zafar Khawaja, Iffat Aqeel, . Hidayatullah, Mahboob Ur Rehman, Sumeet Kumar, Shoaib Ahmed
Pakistan Journal of Health Sciences.2023; : 126. CrossRef
Anatomical and Neuromuscular Factors Associated to Non-Contact Anterior Cruciate Ligament Injury
Marc Dauty, Vincent Crenn, Bastien Louguet, Jérôme Grondin, Pierre Menu, Alban Fouasson-Chailloux
Journal of Clinical Medicine.2022; 11(5): 1402. CrossRef
Prevalence of asymptomatic silent myocardial ischemia among type 2 diabetes mellitus patients in Bangalore - A hospital-based cross-sectional study
NagappaH Handargal, ShristiJ Shetty
Journal of the Practice of Cardiovascular Sciences.2021; 7(3): 207. CrossRef
Influence of sex on the incidence of potential coronary artery disease and long-term outcomes in asymptomatic patients with diabetes mellitus
Chisato Sato, Kohei Wakabayashi, Naoko Ikeda, Yuki Honda, Ken Sato, Toshiaki Suzuki, Keita Shibata, Kaoru Tanno
IJC Heart & Vasculature.2020; 27: 100504. CrossRef
Gauging the Positive Predictive Value of Exercise Tolerance Test Using Angiographic Evaluation: A Cross-Sectional Analysis From a Developing Country
Ismail Khan, Maria Hasan, Javeria Hasan, Ali Imran Dhillon, Moosa Khan, Mehwish Kaneez
Cureus.2020;[Epub] CrossRef
EVALUATION OF SILENT MYOCARDIAL ISCHEMIA IN ASYMPTOMATIC TYPE 2 DIABETES MELLITUS PATIENTS BY TREAD MILL TEST IN TERTIARY CARE CENTER IN SOUTH INDIA
Malepati Sai Sarath Reddy, Uma Mylandlahalli Anandkumar, Srinivasa Rao
Journal of Evolution of Medical and Dental Sciences.2019; 8(10): 740. CrossRef
Breathlessness and Restrictive Lung Disease: An Important Diabetes-Related Feature in Patients with Type 2 Diabetes
Stefan Kopf, Jan B. Groener, Zoltan Kender, Thomas Fleming, Maik Brune, Christin Riedinger, Nadine Volk, Esther Herpel, Dominik Pesta, Julia Szendrödi, Mark O. Wielpütz, Hans-Ulrich Kauczor, Hugo A. Katus, Michael Kreuter, Peter P. Nawroth
Respiration.2018; 96(1): 29. CrossRef
Comparison of the presence of fragmented QRS complexes in the inferior versus the anterior leads for predicting coronary artery disease severity
Mehmet Eyuboglu, Ugur Kucuk, Omer Senarslan, Bahri Akdeniz
Revista Portuguesa de Cardiologia.2017; 36(2): 89. CrossRef
Comparison of the presence of fragmented QRS complexes in the inferior versus the anterior leads for predicting coronary artery disease severity
Mehmet Eyuboglu, Ugur Kucuk, Omer Senarslan, Bahri Akdeniz
Revista Portuguesa de Cardiologia (English Edition).2017; 36(2): 89. CrossRef
High serum YKL-40 level positively correlates with coronary artery disease
Yan Jin, Jia-Ning Cao, Chun-Xia Wang, Qiu-Ting Feng, Xin-He Ye, Xin Xu, Cheng-Jian Yang
Biomarkers in Medicine.2017; 11(2): 133. CrossRef
Fragmented QRS Is Associated with Improved Predictive Value of Exercise Treadmill Testing in Patients with Intermediate Pretest Likelihood of Significant Coronary Artery Disease
Eyyup Tusun, Abdulselam Ilter, Feyzullah Besli, Emre Erkus, Ibrahim Halil Altiparmak, Mehmet Bozbay
Annals of Noninvasive Electrocardiology.2016; 21(2): 196. CrossRef
Use of imaging and clinical data to screen for cardiovascular disease in asymptomatic diabetics
Carlos Henrique Reis Esselin Rassi, Timothy W. Churchill, Carlos A. Fernandes Tavares, Mateus Guimaraes Fahel, Fabricia P. O. Rassi, Augusto H. Uchida, Bernardo L. Wajchenberg, Antonio C. Lerario, Edward Hulten, Khurram Nasir, Márcio S. Bittencourt, Carlo
Cardiovascular Diabetology.2016;[Epub] CrossRef
Obese sedentary patients with dyspnoea on exertion who are at low risk for coronary artery disease by clinical criteria have a very low prevalence of coronary artery disease
J. T. Bruckel, G. Larsen, M. R. Benson
Clinical Obesity.2014; 4(3): 143. CrossRef
Potential association between coronary artery disease and the inflammatory biomarker YKL-40 in asymptomatic patients with type 2 diabetes mellitus
Hyun Min Kim, Byung-Wan Lee, Young-Mi Song, Won Jin Kim, Hyuk-Jae Chang, Dong-Hoon Choi, Hee Tae Yu, EunSeok Kang, Bong Soo Cha, Hyun Chul Lee
Cardiovascular Diabetology.2012;[Epub] CrossRef
Exercise Treadmill Test for Evaluation of Cardiovascular Disease in Diabetic Patients
Ju Youn Kim, Mee Kyoung Kim, Woo-Baek Chung
The Journal of Korean Diabetes.2012; 13(4): 182. CrossRef

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