KDA
- Current
- Browse
- Collections
-
For contributors
- For Authors
- Instructions to authors
- Article processing charge
- e-submission
- For Reviewers
- Instructions for reviewers
- How to become a reviewer
- Best reviewers
- For Readers
- Readership
- Subscription
- Permission guidelines
- About
- Editorial policy
Search
- Page Path
- HOME > Search
Review
- Pathophysiology
- Glial and Vascular Cell Regulation of the Blood-Brain Barrier in Diabetes
- Xiaolong Li, Yan Cai, Zuo Zhang, Jiyin Zhou
- Diabetes Metab J. 2022;46(2):222-238. Published online March 18, 2022
- DOI: https://doi.org/10.4093/dmj.2021.0146
- 6,284 View
- 298 Download
- 12 Web of Science
- 12 Crossref
-
Abstract
PDF
PubReader 
ePub - As a structural barrier, the blood-brain barrier (BBB) is located at the interface between the brain parenchyma and blood, and modulates communication between the brain and blood microenvironment to maintain homeostasis. The BBB is composed of endothelial cells, basement membrane, pericytes, and astrocytic end feet. BBB impairment is a distinguishing and pathogenic factor in diabetic encephalopathy. Diabetes causes leakage of the BBB through downregulation of tight junction proteins, resulting in impaired functioning of endothelial cells, pericytes, astrocytes, microglia, nerve/glial antigen 2-glia, and oligodendrocytes. However, the temporal regulation, mechanisms of molecular and signaling pathways, and consequences of BBB impairment in diabetes are not well understood. Consequently, the efficacy of therapies diabetes targeting BBB leakage still lags behind the requirements. This review summarizes the recent research on the effects of diabetes on BBB composition and the potential roles of glial and vascular cells as therapeutic targets for BBB disruption in diabetic encephalopathy.
-
Citations
Citations to this article as recorded by
- Gut microbiota and type 2 diabetes mellitus: a focus on the gut-brain axis
Yi Pan, Tong Bu, Xia Deng, Jue Jia, Guoyue Yuan
Endocrine.2024; 84(1): 1. CrossRef - Long-Term Exposure of Cultured Astrocytes to High Glucose Impact on Their LPS-Induced Activation
Ayna Abdyeva, Ekaterina Kurtova, Irina Savinkova, Maksim Galkov, Liubov Gorbacheva
International Journal of Molecular Sciences.2024; 25(2): 1122. CrossRef - Role of autophagy in angiogenic potential of vascular pericytes
Soheil Zamen Milani, Aysa Rezabakhsh, Mohammad Karimipour, Leila Salimi, Narges Mardi, Maryam Taghavi Narmi, Fatemeh Sadeghsoltani, Ferzane Valioglu, Reza Rahbarghazi
Frontiers in Cell and Developmental Biology.2024;[Epub] CrossRef - The NG2-glia is a potential target to maintain the integrity of neurovascular unit after acute ischemic stroke
Xiaoyan Hu, Panpan Geng, Xiaoyun Zhao, Qian Wang, Changqing Liu, Chun Guo, Wen Dong, Xinchun Jin
Neurobiology of Disease.2023; 180: 106076. CrossRef - Tight junction disruption and the pathogenesis of the chronic complications of diabetes mellitus: A narrative review
Ma Ludivina Robles-Osorio, Ernesto Sabath
World Journal of Diabetes.2023; 14(7): 1013. CrossRef - Function and therapeutic value of astrocytes in diabetic cognitive impairment
Fanyu Meng, Jiafeng Fu, Lin Zhang, Mengqing Guo, Pengwei Zhuang, Qingsheng Yin, Yanjun Zhang
Neurochemistry International.2023; 169: 105591. CrossRef - Exploring the molecular targets for Type 2 diabetes-induced Alzheimer’s disease through bioinformatics analysis
Lin Gao, Chengyu Huang, Hui Li, Shidi Wu, Xiaoyan Zhou, Changjiang Ying
Epigenomics.2023; 15(11): 619. CrossRef - In vivo retinal imaging is associated with cognitive decline, blood-brain barrier disruption and neuroinflammation in type 2 diabetic mice
May Majimbi, Samuel McLenachan, Michael Nesbit, Fred K. Chen, Virginie Lam, John Mamo, Ryu Takechi
Frontiers in Endocrinology.2023;[Epub] CrossRef - Diabetic microvascular disease in non-classical beds: the hidden impact beyond the retina, the kidney, and the peripheral nerves
Dídac Mauricio, Mònica Gratacòs, Josep Franch-Nadal
Cardiovascular Diabetology.2023;[Epub] CrossRef - Transcranial photobiomodulation improves insulin therapy in diabetic microglial reactivity and the brain drainage system
Shaojun Liu, Dongyu Li, Tingting Yu, Jingtan Zhu, Oxana Semyachkina-Glushkovskaya, Dan Zhu
Communications Biology.2023;[Epub] CrossRef - NG2‐glia crosstalk with microglia in health and disease
Zuo Zhang, Xiaolong Li, Hongli Zhou, Jiyin Zhou
CNS Neuroscience & Therapeutics.2022; 28(11): 1663. CrossRef - Accelerated amyloid angiopathy and related vascular alterations in a mixed murine model of Alzheimer´s disease and type two diabetes
Maria Vargas-Soria, Juan Jose Ramos-Rodriguez, Angel del Marco, Carmen Hierro-Bujalance, Maria Jose Carranza-Naval, Maria Calvo-Rodriguez, Susanne J. van Veluw, Alan W. Stitt, Rafael Simó, Brian J. Bacskai, Carmen Infante-Garcia, Monica Garcia-Alloza
Fluids and Barriers of the CNS.2022;[Epub] CrossRef
- Gut microbiota and type 2 diabetes mellitus: a focus on the gut-brain axis
First
Prev
