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Review Metabolic Risk/Epidemiology Glucagon-Like Peptide-1: New Regulator in Lipid Metabolism
Tong Buorcid , Ziyan Sun, Yi Pan, Xia Dengorcid , Guoyue Yuanorcid

DOI: https://doi.org/10.4093/dmj.2023.0277 [Epub ahead of print]
Published online: April 1, 2024
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Department of Endocrinology, Affiliated Hospital of Jiangsu University, Zhenjiang, China
Corresponding author:  Xia Deng,
Email: dengxia11@outlook.com
Guoyue Yuan,
Email: yuanguoyue@ ujs.edu.cn
Received: 14 August 2023   • Accepted: 1 January 2024

Glucagon-like peptide-1 (GLP-1) is a 30-amino acid peptide hormone that is mainly expressed in the intestine and hypothalamus. In recent years, basic and clinical studies have shown that GLP-1 is closely related to lipid metabolism, and it can participate in lipid metabolism by inhibiting fat synthesis, promoting fat differentiation, enhancing cholesterol metabolism, and promoting adipose browning. GLP-1 plays a key role in the occurrence and development of metabolic diseases such as obesity, nonalcoholic fatty liver disease, and atherosclerosis by regulating lipid metabolism. It is expected to become a new target for the treatment of metabolic disorders. The effects of GLP-1 and dual agonists on lipid metabolism also provide a more complete treatment plan for metabolic diseases. This article reviews the recent research progress of GLP-1 in lipid metabolism.

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