Citations

Citations to this article as recorded by  

• Insights on effects of Wnt pathway modulation on insulin signaling and glucose homeostasis for the treatment of type 2 diabetes mellitus: Wnt activation or Wnt inhibition?
  Ruchi Yadav, Bhumika Patel
  International Journal of Biological Macromolecules.2024; 261: 129634.     CrossRef
• Evaluating the correlation of sclerostin levels with obesity and type 2 diabetes in a multiethnic population living in Kuwait
  Tahani Alramah, Preethi Cherian, Irina Al-Khairi, Mohamed Abu-Farha, Thangavel Alphonse Thanaraj, Ahmed N. Albatineh, Fayez Safadi, Hamad Ali, Muhammad Abdul-Ghani, Jaakko Tuomilehto, Heikki A. Koistinen, Fahd Al-Mulla, Jehad Abubaker
  Frontiers in Endocrinology.2024;[Epub]     CrossRef
• The role of the Wnt signalling pathway in the energy metabolism of bone remodelling
  Mengyuan Zhu, Zhipeng Fan
  Cell Proliferation.2022;[Epub]     CrossRef
• Transcriptomic analysis provides a new insight: Oleuropein reverses high glucose-induced osteogenic inhibition in bone marrow mesenchymal stem cells via Wnt10b activation
  An Lao, Yu Chen, Yiting Sun, Tiange Wang, Kaili Lin, Jiaqiang Liu, Jianyong Wu
  Frontiers in Bioengineering and Biotechnology.2022;[Epub]     CrossRef
• Subcutaneous adipose tissue sclerostin is reduced and Wnt signaling is enhanced following 4‐weeks of sprint interval training in young men with obesity
  Nigel Kurgan, Hashim Islam, Jennifer B. L. Matusiak, Bradley J. Baranowski, Joshua Stoikos, Val A. Fajardo, Rebecca E. K. MacPherson, Brendon J. Gurd, Panagiota Klentrou
  Physiological Reports.2022;[Epub]     CrossRef
• Circulating Levels of Sclerostin Predict Glycemic Improvement after Sleeve Gastrectomy
  Federico Carbone, Elisa Nulli Migliola, Aldo Bonaventura, Alessandra Vecchié, Stefano De Vuono, Maria Anastasia Ricci, Gaetano Vaudo, Marcello Boni, Stefano Ministrini, Graziana Lupattelli, Fabrizio Montecucco
  Nutrients.2021; 13(2): 623.     CrossRef
• Serum sclerostin concentration is associated with specific adipose, muscle and bone tissue markers in lean adolescent females with increased physical activity
  Jaak Jürimäe, Vita Karvelyte, Liina Remmel, Anna-Liisa Tamm, Priit Purge, Rita Gruodyte-Raciene, Sigitas Kamandulis, Katre Maasalu, Luis Gracia-Marco, Vallo Tillmann
  Journal of Pediatric Endocrinology and Metabolism.2021; 34(6): 755.     CrossRef
• The complex role of Wnt ligands in type 2 diabetes mellitus and related complications
  Xiaobo Nie, Xiaoyun Wei, Han Ma, Lili Fan, Wei‐Dong Chen
  Journal of Cellular and Molecular Medicine.2021; 25(14): 6479.     CrossRef

Obesity has become a common healthcare problem worldwide. Cilia are tiny hair-like organelles on the cell surface that are generated and anchored by the basal body. Non-motile primary cilia have been considered to be evolutionary rudiments until a few decades, but they are now considered as important signaling organelles because many receptors, channels, and signaling molecules are highly expressed in primary cilia. A potential role of primary cilia in metabolic regulation and body weight maintenance has been suspected based on rare genetic disorders termed as ciliopathy, such as Bardet-Biedl syndrome and Alström syndrome, which manifest as obesity. Recent studies have demonstrated involvement of cilia-related cellular signaling pathways in transducing metabolic information in hypothalamic neurons and in determining cellular fate during adipose tissue development. In this review, we summarize the current knowledge about cilia and cilia-associated signaling pathways in the regulation of body metabolism.

Citations

Citations to this article as recorded by  

• MRAP2 regulates energy homeostasis by promoting primary cilia localization of MC4R
  Adelaide Bernard, Irene Ojeda Naharros, Xinyu Yue, Francois Mifsud, Abbey Blake, Florence Bourgain-Guglielmetti, Jordi Ciprin, Sumei Zhang, Erin McDaid, Kellan Kim, Maxence V. Nachury, Jeremy F. Reiter, Christian Vaisse
  JCI Insight.2023;[Epub]     CrossRef
• A high‐confidence Physcomitrium patens plasmodesmata proteome by iterative scoring and validation reveals diversification of cell wall proteins during evolution
  Sven Gombos, Manuel Miras, Vicky Howe, Lin Xi, Mathieu Pottier, Neda S. Kazemein Jasemi, Moritz Schladt, J. Obinna Ejike, Ulla Neumann, Sebastian Hänsch, Franziska Kuttig, Zhaoxia Zhang, Marcel Dickmanns, Peng Xu, Thorsten Stefan, Wolfgang Baumeister, Wol
  New Phytologist.2023; 238(2): 637.     CrossRef
• Primary cilia shape hallmarks of health and aging
  Diana Filipa Silva, Cláudia Cavadas
  Trends in Molecular Medicine.2023; 29(7): 567.     CrossRef
• Therapeutic implications of sonic hedgehog pathway in metabolic disorders: Novel target for effective treatment
  Chahat Garg, Heena khan, Amarjot Kaur, Thakur Gurjeet Singh, Vivek Kumar Sharma, Sachin Kumar Singh
  Pharmacological Research.2022; 179: 106194.     CrossRef
• Mechanisms of Weight Control by Primary Cilia
  Chan Hee Lee, Gil Myoung Kang, Min-Seon Kim
  Molecules and Cells.2022; 45(4): 169.     CrossRef
• Cilia-localized GID/CTLH ubiquitin ligase complex regulates protein homeostasis of sonic hedgehog signaling components
  Friederike Hantel, Huaize Liu, Lisa Fechtner, Herbert Neuhaus, Jie Ding, Danilo Arlt, Peter Walentek, Pablo Villavicencio-Lorini, Christoph Gerhardt, Thomas Hollemann, Thorsten Pfirrmann
  Journal of Cell Science.2022;[Epub]     CrossRef
• IFT20 governs mesenchymal stem cell fate through positively regulating TGF-β-Smad2/3-Glut1 signaling mediated glucose metabolism
  Yang Li, Shuting Yang, Yang Liu, Ling Qin, Shuying Yang
  Redox Biology.2022; 54: 102373.     CrossRef
• Primary Cilia in Pancreatic β- and α-Cells: Time to Revisit the Role of Insulin-Degrading Enzyme
  Marta Pablos, Elena Casanueva-Álvarez, Carlos M. González-Casimiro, Beatriz Merino, Germán Perdomo, Irene Cózar-Castellano
  Frontiers in Endocrinology.2022;[Epub]     CrossRef
• Palmitic acid control of ciliogenesis modulates insulin signaling in hypothalamic neurons through an autophagy-dependent mechanism
  Yenniffer Ávalos, María Paz Hernández-Cáceres, Pablo Lagos, Daniela Pinto-Nuñez, Patricia Rivera, Paulina Burgos, Francisco Díaz-Castro, Michelle Joy-Immediato, Leslye Venegas-Zamora, Erik Lopez-Gallardo, Catalina Kretschmar, Ana Batista-Gonzalez, Flavia
  Cell Death & Disease.2022;[Epub]     CrossRef
• Shedding of ciliary vesicles at a glance
  Irene Ojeda Naharros, Maxence V. Nachury
  Journal of Cell Science.2022;[Epub]     CrossRef
• Oligodendroglial primary cilium heterogeneity during development and demyelination/remyelination
  Giada Delfino, Karelle Bénardais, Julien Graff, Brigitte Samama, Maria Cristina Antal, M. Said Ghandour, Nelly Boehm
  Frontiers in Cellular Neuroscience.2022;[Epub]     CrossRef
• Proteomic and Transcriptomic Landscapes of Alström and Bardet–Biedl Syndromes
  Urszula Smyczynska, Marcin Stanczak, Miljan Kuljanin, Aneta Włodarczyk, Ewelina Stoczynska-Fidelus, Joanna Taha, Bartłomiej Pawlik, Maciej Borowiec, Joseph D. Mancias, Wojciech Mlynarski, Piotr Rieske, Wojciech Fendler, Agnieszka Zmysłowska
  Genes.2022; 13(12): 2370.     CrossRef
• A role for primary cilia in coral calcification?
  Eric Tambutté, Philippe Ganot, Alexander A Venn, Sylvie Tambutté
  Cell and Tissue Research.2021; 383(3): 1093.     CrossRef
• Myocardin-related transcription factor and serum response factor regulate cilium turnover by both transcriptional and local mechanisms
  Pam Speight, Matthew Rozycki, Shruthi Venugopal, Katalin Szászi, Michael Kofler, András Kapus
  iScience.2021; 24(7): 102739.     CrossRef
• Hypothalamic primary cilium: A hub for metabolic homeostasis
  Dong Joo Yang, Jessica Hong, Ki Woo Kim
  Experimental & Molecular Medicine.2021; 53(7): 1109.     CrossRef
• Low fluid shear stress promoted ciliogenesis via Dvl2 in hUVECs
  Xin Sheng, Yan Sheng, Shuanglin Gao, Fang Fan, Junhua Wang
  Histochemistry and Cell Biology.2020; 154(6): 639.     CrossRef
• Primary cilia mediate early life programming of adiposity through lysosomal regulation in the developing mouse hypothalamus
  Chan Hee Lee, Do Kyeong Song, Chae Beom Park, Jeewon Choi, Gil Myoung Kang, Sung Hoon Shin, Ijoo Kwon, Soyoung Park, Seongjun Kim, Ji Ye Kim, Hong Dugu, Jae Woo Park, Jong Han Choi, Se Hee Min, Jong-Woo Sohn, Min-Seon Kim
  Nature Communications.2020;[Epub]     CrossRef
• Evidences of a Direct Relationship between Cellular Fuel Supply and Ciliogenesis Regulated by Hypoxic VDAC1-ΔC
  Monique Meyenberg Cunha-de Padua, Lucilla Fabbri, Maeva Dufies, Sandra Lacas-Gervais, Julie Contenti, Charles Voyton, Sofia Fazio, Marie Irondelle, Baharia Mograbi, Matthieu Rouleau, Nirvana Sadaghianloo, Amandine Rovini, Catherine Brenner, William J. Cra
  Cancers.2020; 12(11): 3484.     CrossRef
• High-resolution characterization of centriole distal appendage morphology and dynamics by correlative STORM and electron microscopy
  Mathew Bowler, Dong Kong, Shufeng Sun, Rashmi Nanjundappa, Lauren Evans, Veronica Farmer, Andrew Holland, Moe R. Mahjoub, Haixin Sui, Jadranka Loncarek
  Nature Communications.2019;[Epub]     CrossRef
• Sonic hedgehog signaling instigates high-fat diet–induced insulin resistance by targeting PPARγ stability
  Qinyu Yao, Jia Liu, Lei Xiao, Nanping Wang
  Journal of Biological Chemistry.2019; 294(9): 3284.     CrossRef
• Cellular signalling by primary cilia in development, organ function and disease
  Zeinab Anvarian, Kirk Mykytyn, Saikat Mukhopadhyay, Lotte Bang Pedersen, Søren Tvorup Christensen
  Nature Reviews Nephrology.2019; 15(4): 199.     CrossRef
• O-GlcNAcylation Regulates Primary Ciliary Length by Promoting Microtubule Disassembly
  Jie L. Tian, Hongmin Qin
  iScience.2019; 12: 379.     CrossRef
• Interplay Between Primary Cilia and Autophagy and Its Controversial Roles in Cancer
  Je Yeong Ko, Eun Ji Lee, Jong Hoon Park
  Biomolecules & Therapeutics.2019; 27(4): 337.     CrossRef
• Neuronal and astrocytic primary cilia in the mature brain
  Ashley Sterpka, Xuanmao Chen
  Pharmacological Research.2018; 137: 114.     CrossRef