Citations

Citations to this article as recorded by  

• Wharton’s Jelly Mesenchymal Stem Cell Conditioned Medium Ameliorates Diabetes‐Induced Testicular Damage and Sperm Abnormalities by Mitigating Oxidative Stress, Apoptosis, and Inflammation
  Mojtaba Sargazi, Narges Karbalaei, Saied Karbalay-Doust, Sara Keshtgar, Zohre Aghaei, Pasquale Marrazzo
  Stem Cells International.2024;[Epub]     CrossRef
• Secretome Derived from Mesenchymal Stem/Stromal Cells: A Promising Strategy for Diabetes and its Complications
  ling li, Siyu Hua, Lianghui You, Tianying Zhong
  Current Stem Cell Research & Therapy.2024; 19(10): 1328.     CrossRef
• Neurotransmitters in Type 2 Diabetes and the Control of Systemic and Central Energy Balance
  Amnah Al-Sayyar, Maha M. Hammad, Michayla R. Williams, Mohammed Al-Onaizi, Jehad Abubaker, Fawaz Alzaid
  Metabolites.2023; 13(3): 384.     CrossRef
• Neuroprotective Effect of Wharton’s Jelly-Derived Mesenchymal Stem Cell-Conditioned Medium (WJMSC-CM) on Diabetes-Associated Cognitive Impairment by Improving Oxidative Stress, Neuroinflammation, and Apoptosis
  Zohre Aghaei, Narges Karbalaei, Mohammad Reza Namavar, Masoud Haghani, Mahboobeh Razmkhah, Mahdi Khorsand Ghaffari, Marzieh Nemati, Andrea Ballini
  Stem Cells International.2023; 2023: 1.     CrossRef
• Mesenchymal-Stem Cell-Derived Conditioned Media Versus Exosomes in the Treatment of Rat Model of Polycystic Ovary: An Attempt to Understand the Underlying Mechanisms (Biochemical and Histological Study)
  Soha Abd-elkawy Abd-elwahab, Noura Hassan Khamis, Rehab Ahmed Rifaai, Nashwa Fathy Gamal El-Tahawy, Randa Ahmed Ibrahim
  Microscopy and Microanalysis.2023; 29(3): 1244.     CrossRef
• Therapeutic Potential of Mesenchymal Stem Cell‐Derived Conditioned Medium for Diabetes Mellitus and Related Complications
  Basak Isildar, Serbay Ozkan, Meral Koyuturk
  Advanced Therapeutics.2023;[Epub]     CrossRef
• Treatment of type 2 diabetes mellitus with stem cells and antidiabetic drugs: a dualistic and future-focused approach
  Priyamvada Amol Arte, Kanchanlata Tungare, Mustansir Bhori, Renitta Jobby, Jyotirmoi Aich
  Human Cell.2023; 37(1): 54.     CrossRef
• Perinatal Stem Cell Therapy to Treat Type 1 Diabetes Mellitus: A Never-Say-Die Story of Differentiation and Immunomodulation
  Francesca Paris, Valeria Pizzuti, Pasquale Marrazzo, Andrea Pession, Francesco Alviano, Laura Bonsi
  International Journal of Molecular Sciences.2022; 23(23): 14597.     CrossRef
• Mesenchymal Stem Cell-Derived Apoptotic Bodies: Biological Functions and Therapeutic Potential
  Huixue Tang, Huikun Luo, Zihan Zhang, Di Yang
  Cells.2022; 11(23): 3879.     CrossRef
• Human umbilical cord mesenchymal stem cells in type 2 diabetes mellitus: the emerging therapeutic approach
  Andreia Gomes, Pedro Coelho, Raquel Soares, Raquel Costa
  Cell and Tissue Research.2021; 385(3): 497.     CrossRef

Obesity, diabetes, and cardiovascular diseases are increasing rapidly worldwide and it is therefore important to know the effect of exercise and medications for diabetes and obesity on adult stem cells. Adult stem cells play a major role in remodeling and tissue regeneration. In this review we will focus mainly on two adult stem/progenitor cells such as endothelial progenitor cells and mesenchymal stromal cells in relation to aerobic exercise and diabetes medications, both of which can alter the course of regeneration and tissue remodelling. These two adult precursor and stem cells are easily obtained from peripheral blood or adipose tissue depots, as the case may be and are precursors to endothelium and mesenchymal tissue (fat, bone, muscle, and cartilage). They both are key players in maintenance of cardiovascular and metabolic homeostasis and can act also as useful biomarkers.

Citations

Citations to this article as recorded by  

• Novel Therapeutics in Nonalcoholic Fatty Liver Disease: A Focus on Adult Stem Cells
  Seshagiri Rao Nandula, Eric S. Nylen, Sabyasachi Sen
  Metabolic Syndrome and Related Disorders.2023; 21(2): 71.     CrossRef
• Obesity and Wound Healing: Focus on Mesenchymal Stem Cells
  Antonio Alma, Guya Diletta Marconi, Elena Rossi, Cristina Magnoni, Alessia Paganelli
  Life.2023; 13(3): 717.     CrossRef
• Stem Cells in Tendon Regeneration and Factors governing Tenogenesis
  Lingli Ding, BingYu Zhou, Yonghui Hou, Liangliang Xu
  Current Stem Cell Research & Therapy.2022; 17(6): 503.     CrossRef
• Role of Canagliflozin on function of CD34+ve endothelial progenitor cells (EPC) in patients with type 2 diabetes
  Seshagiri Rao Nandula, Nabanita Kundu, Hassan B. Awal, Beda Brichacek, Mona Fakhri, Nikhila Aimalla, Adrian Elzarki, Richard L. Amdur, Sabyasachi Sen
  Cardiovascular Diabetology.2021;[Epub]     CrossRef
• Tailored generation of insulin producing cells from canine mesenchymal stem cells derived from bone marrow and adipose tissue
  Watchareewan Rodprasert, Sirirat Nantavisai, Koranis Pathanachai, Prasit Pavasant, Thanaphum Osathanon, Chenphop Sawangmake
  Scientific Reports.2021;[Epub]     CrossRef

Chronic energy surplus increases body fat, leading to obesity. Since obesity is closely associated with most metabolic complications, pathophysiological roles of adipose tissue in obesity have been intensively studied. White adipose tissue is largely divided into subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT). These two white adipose tissues are similar in their appearance and lipid storage functions. Nonetheless, emerging evidence has suggested that SAT and VAT have different characteristics and functional roles in metabolic regulation. It is likely that there are intrinsic differences between VAT and SAT. In diet-induced obese animal models, it has been reported that adipogenic progenitors in VAT rapidly proliferate and differentiate into adipocytes. In obesity, VAT exhibits elevated inflammatory responses, which are less prevalent in SAT. On the other hand, SAT has metabolically beneficial effects. In this review, we introduce recent studies that focus on cellular and molecular components modulating adipogenesis and immune responses in SAT and VAT. Given that these two fat depots show different functions and characteristics depending on the nutritional status, it is feasible to postulate that SAT and VAT have different developmental origins with distinct adipogenic progenitors, which would be a key determining factor for the response and accommodation to metabolic input for energy homeostasis.

Citations

Citations to this article as recorded by  

• Lipodystrophy as a target to delay premature aging
  Daniela G. Costa, Marisa Ferreira-Marques, Cláudia Cavadas
  Trends in Endocrinology & Metabolism.2024; 35(2): 97.     CrossRef
• Subcutaneous fat predicts bone metastasis in breast cancer: A novel multimodality-based deep learning model
  Shidi Miao, Haobo Jia, Wenjuan Huang, Ke Cheng, Wenjin Zhou, Ruitao Wang
  Cancer Biomarkers.2024; 39(3): 171.     CrossRef
• Association between abdominal adiposity and clinical outcomes in patients with acute ischemic stroke
  Kayo Wakisaka, Ryu Matsuo, Fumi Irie, Yoshinobu Wakisaka, Tetsuro Ago, Masahiro Kamouchi, Takanari Kitazono, Masaki Mogi
  PLOS ONE.2024; 19(1): e0296833.     CrossRef
• NOTCH1 as a Negative Regulator of Avian Adipocyte Differentiation: Implications for Fat Deposition
  Zheng Wang, Yue Su, Mingyu Zhao, Zhenhua Ma, Jianhui Li, Zhuocheng Hou, Huifeng Li
  Animals.2024; 14(4): 585.     CrossRef
• Visceral adipose of obese mice inhibits endothelial inwardly rectifying K+ channels in a CD36-dependent fashion
  Sabita Rokka, Masoumeh Sadeghinejad, Emma C. Hudgins, Erica J. Johnson, Thanh Nguyen, Ibra S. Fancher
  American Journal of Physiology-Cell Physiology.2024; 326(5): C1543.     CrossRef
• Adipose-derived mesenchymal stromal cells in clinical trials: Insights from single-cell studies
  Anna Kostecka, Natalia Kalamon, Aneta Skoniecka, Magdalena Koczkowska, Piotr M. Skowron, Arkadiusz Piotrowski, Michał Pikuła
  Life Sciences.2024; 351: 122761.     CrossRef
• Dynamics of single-nuclei transcriptomic profiling of adipose tissue from diverse anatomical locations during mouse aging process
  Yujie Wu, Ying Sun, Long Chen, Xingyan Tong, Can Liu, Lu Lu, Rui Zhang, Siyuan Wang, Ziyu Chen, Jiaman Zhang, Ziyin Han, Bo Zeng, Mingzhou Li, Long Jin
  Scientific Reports.2024;[Epub]     CrossRef
• Glucose metabolism and radiodensity of abdominal adipose tissue: A 5‐year longitudinal study in a large PET cohort
  Kyoungjune Pak, Severi Santavirta, Seunghyeon Shin, Hyun‐Yeol Nam, Sven De Maeyer, Lauri Nummenmaa
  Clinical Endocrinology.2024; 101(6): 623.     CrossRef
• The association of obesity and the risk of rheumatoid arthritis according to abdominal obesity status: a nationwide population-based study in Korea
  Jung Sun Lee, Ji Seon Oh, Sehee Kim, Ye-Jee Kim, Seokchan Hong, Yong-Gil Kim, Chang-Keun Lee, Bin Yoo
  Rheumatology International.2024;[Epub]     CrossRef
• Green tea beneficial effects involve changes in the profile of immune cells in the adipose tissue of obese mice
  Kaue Tognolli, Victoria Silva, Celso Pereira Batista Sousa-Filho, Claudia Andrea Lima Cardoso, Renata Gorjão, Rosemari Otton
  European Journal of Nutrition.2023; 62(1): 321.     CrossRef
• Mechanic Insight into the Distinct and Common Roles of Ovariectomy Versus Adrenalectomy on Adipose Tissue Remodeling in Female Mice
  Weihao Chen, Fengyan Meng, Xianyin Zeng, Xiaohan Cao, Guixian Bu, Xiaogang Du, Guozhi Yu, Fanli Kong, Yunkun Li, Tian Gan, Xingfa Han
  International Journal of Molecular Sciences.2023; 24(3): 2308.     CrossRef
• High-fat diet consumption by male rat offspring of obese mothers exacerbates adipose tissue hypertrophy and metabolic alterations in adult life
  Guadalupe L. Rodríguez-González, Sergio De Los Santos, Dayana Méndez-Sánchez, Luis A. Reyes-Castro, Carlos A. Ibáñez, Patricia Canto, Elena Zambrano
  British Journal of Nutrition.2023; 130(5): 783.     CrossRef
• Obesity and the risk of cardiometabolic diseases
  Pedro L. Valenzuela, Pedro Carrera-Bastos, Adrián Castillo-García, Daniel E. Lieberman, Alejandro Santos-Lozano, Alejandro Lucia
  Nature Reviews Cardiology.2023; 20(7): 475.     CrossRef
• Abdominal fat and muscle distributions in different stages of colorectal cancer
  Jun Han, Xinyang Liu, Min Tang, Fan Yang, Zuoyou Ding, Guohao Wu
  BMC Cancer.2023;[Epub]     CrossRef
• Expression Analysis of hsa-miR-181a-5p, hsa-miR-143-3p, hsa-miR-132-3p and hsa-miR-23a-3p as Biomarkers in Colorectal Cancer—Relationship to the Body Mass Index
  Sofía Elena Tesolato, Daniel González-Gamo, Ana Barabash, Paula Claver, Sofía Cristina de la Serna, Inmaculada Domínguez-Serrano, Jana Dziakova, Carmen de Juan, Antonio José Torres, Pilar Iniesta
  Cancers.2023; 15(13): 3324.     CrossRef
• Lower subcutaneous fat index predicts bone metastasis in breast cancer
  Wen Wang, Wen-Juan Huang, Ping-Ping Liu, Shuang Fu, Meng-Lin Zhang, Xin Zhang, Rui-Tao Wang, Yuan-Xi Huang
  Cancer Biomarkers.2023; 38(1): 121.     CrossRef
• RabGAP AS160/TBC1D4 deficiency increases long-chain fatty acid transport but has little additional effect on obesity and metabolic syndrome in ADMSCs-derived adipocytes of morbidly obese women
  Agnieszka Mikłosz, Bartłomiej Łukaszuk, Elżbieta Supruniuk, Kamil Grubczak, Magdalena Kusaczuk, Adrian Chabowski
  Frontiers in Molecular Biosciences.2023;[Epub]     CrossRef
• White adipose tissue: Distribution, molecular insights of impaired expandability, and its implication in fatty liver disease
  Griselda Rabadán-Chávez, Rocío I. Díaz de la Garza, Daniel A. Jacobo-Velázquez
  Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2023; 1869(8): 166853.     CrossRef
• Histological pattern and gene expression profiling of thyroid tissue in subjects with obesity
  A. Basolo, A. M. Poma, R. Giannini, G. Ceccarini, C. Pelosini, P. Fierabracci, M. U. Castany, S. Bechi Genzano, C. E. Ambrosini, G. Materazzi, L. Chiovato, F. Basolo, F. Santini, L. Torregrossa
  Journal of Endocrinological Investigation.2022; 45(2): 413.     CrossRef
• Predictors of non-alcoholic fatty liver disease in children
  Menglong Li, Wen Shu, Jiawulan Zunong, Nubiya Amaerjiang, Huidi Xiao, Dan Li, Sten H. Vermund, Yifei Hu
  Pediatric Research.2022; 92(1): 322.     CrossRef
• Distinct properties of adipose stem cell subpopulations determine fat depot-specific characteristics
  Hahn Nahmgoong, Yong Geun Jeon, Eun Seo Park, Yoon Ha Choi, Sang Mun Han, Jeu Park, Yul Ji, Jee Hyung Sohn, Ji Seul Han, Ye Young Kim, Injae Hwang, Yun Kyung Lee, Jin Young Huh, Sung Sik Choe, Tae Jung Oh, Sung Hee Choi, Jong Kyoung Kim, Jae Bum Kim
  Cell Metabolism.2022; 34(3): 458.     CrossRef
• WT1 in Adipose Tissue: From Development to Adult Physiology
  Karin M. Kirschner, Holger Scholz
  Frontiers in Cell and Developmental Biology.2022;[Epub]     CrossRef
• Shall We Begin the Voyage of Adipose Tissue Exploration?
  Yong Geun Jeon
  Molecules and Cells.2022; 45(6): 362.     CrossRef
• Mammalian adipogenesis regulator (Areg) cells use retinoic acid signalling to be non‐ and anti‐adipogenic in age‐dependent manner
  Magda Zachara, Pernille Y Rainer, Horia Hashimi, Julie M Russeil, Daniel Alpern, Radiana Ferrero, Maria Litovchenko, Bart Deplancke
  The EMBO Journal.2022;[Epub]     CrossRef
• The fates of different types of adipose tissue after transplantation in mice
  Shenglu Jiang, Jiayan Lin, Qian Zhang, Yunjun Liao, Feng Lu, Junrong Cai
  The FASEB Journal.2022;[Epub]     CrossRef
• Analysis of different adipose depot gene expression in cachectic patients with gastric cancer
  Jun Han, Zuoyou Ding, Qiulin Zhuang, Lei Shen, Fan Yang, Szechun Sah, Guohao Wu
  Nutrition & Metabolism.2022;[Epub]     CrossRef
• Adipose Stromal/Stem Cell-Derived Extracellular Vesicles: Potential Next-Generation Anti-Obesity Agents
  Mariachiara Zuccarini, Patricia Giuliani, Valentina Di Liberto, Monica Frinchi, Francesco Caciagli, Vanni Caruso, Renata Ciccarelli, Giuseppa Mudò, Patrizia Di Iorio
  International Journal of Molecular Sciences.2022; 23(3): 1543.     CrossRef
• Is There a Link between Obesity Indices and Skin Autofluorescence? A Response from the ILERVAS Project
  Enric Sánchez, Marta Sánchez, Carolina López-Cano, Marcelino Bermúdez-López, José Manuel Valdivielso, Cristina Farràs-Sallés, Reinald Pamplona, Gerard Torres, Dídac Mauricio, Eva Castro, Elvira Fernández, Albert Lecube
  Nutrients.2022; 15(1): 203.     CrossRef
• Insights behind the Relationship between Colorectal Cancer and Obesity: Is Visceral Adipose Tissue the Missing Link?
  Alice Chaplin, Ramon Maria Rodriguez, Juan José Segura-Sampedro, Aina Ochogavía-Seguí, Dora Romaguera, Gwendolyn Barceló-Coblijn
  International Journal of Molecular Sciences.2022; 23(21): 13128.     CrossRef
• Potential effects of nutrition-based weight loss therapies in reversing obesity-related breast cancer epigenetic marks
  Paula M. Lorenzo, Ana B. Crujeiras
  Food & Function.2021; 12(4): 1402.     CrossRef
• Metabolomic Profiles in Adipocytes Differentiated from Adipose-Derived Stem Cells Following Exercise Training or High-Fat Diet
  Seita Osawa, Hisashi Kato, Yuki Maeda, Hisashi Takakura, Junetsu Ogasawara, Tetsuya Izawa
  International Journal of Molecular Sciences.2021; 22(2): 966.     CrossRef
• Adipocytes Are the Control Tower That Manages Adipose Tissue Immunity by Regulating Lipid Metabolism
  Jeu Park, Jee Hyung Sohn, Sang Mun Han, Yoon Jeong Park, Jin Young Huh, Sung Sik Choe, Jae Bum Kim
  Frontiers in Immunology.2021;[Epub]     CrossRef
• Ceramides and Sphingosino-1-Phosphate in Obesity
  Ilona Juchnicka, Mariusz Kuźmicki, Jacek Szamatowicz
  Frontiers in Endocrinology.2021;[Epub]     CrossRef
• Contribution of Adipose Tissue to the Chronic Immune Activation and Inflammation Associated With HIV Infection and Its Treatment
  Christine Bourgeois, Jennifer Gorwood, Anaelle Olivo, Laura Le Pelletier, Jacqueline Capeau, Olivier Lambotte, Véronique Béréziat, Claire Lagathu
  Frontiers in Immunology.2021;[Epub]     CrossRef
• Subcutaneous, but not visceral, adipose tissue as a marker for prognosis in gastric cancer patients with cachexia
  Jun Han, Min Tang, Chaocheng Lu, Lei Shen, Jiaqi She, Guohao Wu
  Clinical Nutrition.2021; 40(9): 5156.     CrossRef
• miR-410-3P inhibits adipocyte differentiation by targeting IRS-1 in cancer-associated cachexia patients
  Diya Sun, Zuoyou Ding, Lei Shen, Fan Yang, Jun Han, Guohao Wu
  Lipids in Health and Disease.2021;[Epub]     CrossRef
• Multipotent Stromal Cells from Subcutaneous Adipose Tissue of Normal Weight and Obese Subjects: Modulation of Their Adipogenic Differentiation by Adenosine A1 Receptor Ligands
  Mariachiara Zuccarini, Catia Lambertucci, Marzia Carluccio, Patricia Giuliani, Maurizio Ronci, Andrea Spinaci, Rosaria Volpini, Renata Ciccarelli, Patrizia Di Iorio
  Cells.2021; 10(12): 3560.     CrossRef
• Obesity: The Crossroads of Opinion, Knowledge, and Opportunity
  L. A. Ruyatkina, D. S. Ruyatkin
  Meditsinskiy sovet = Medical Council.2020; (7): 108.     CrossRef
• Sex Differences in Long-term Metabolic Effects of Maternal Resveratrol Intake in Adult Rat Offspring
  Purificación Ros, Francisca Díaz, Alejandra Freire-Regatillo, Pilar Argente-Arizón, Vicente Barrios, Jesús Argente, Julie A Chowen
  Endocrinology.2020;[Epub]     CrossRef
• Adipose stem cells in obesity: challenges and opportunities
  Sunhye Shin, Asma S. El-Sabbagh, Brandon E. Lukas, Skylar J. Tanneberger, Yuwei Jiang
  Bioscience Reports.2020;[Epub]     CrossRef
• Clinical and pathogenetic rationale for the prevention and treatment of obesity
  O.M. Korzh
  Shidnoevropejskij zurnal vnutrisnoi ta simejnoi medicini.2020; 2020(2): 146.     CrossRef
• OBESITY: CLINICAL AND PATHOGENETIC JUSTIFICATION OF PREVENTION AND TREATMENT
  O. M. Korzh
  International Medical Journal.2020; (2): 5.     CrossRef
• The Effect and Mechanism of Subcutaneous and Visceral Adipose Tissue Loss on Gastric Cancer Patients With Cachexia
  Jun Han, Min Tang, Guyue Zhang, Chaocheng Lu, Jiaqi She, Guohao Wu
  SSRN Electronic Journal .2020;[Epub]     CrossRef

Diabetic neuropathy (DN) is the most common and disabling complication of diabetes that may lead to foot ulcers and limb amputations. Despite widespread awareness of DN, the only effective treatments are glucose control and pain management. A growing body of evidence suggests that DN is characterized by reduction of vascularity in peripheral nerves and deficiency in neurotrophic and angiogenic factors. Previous studies have tried to introduce neurotrophic or angiogenic factors in the form of protein or gene for therapy, but the effect was not significant. Recent studies have shown that bone marrow (BM)-derived stem or progenitor cells have favorable effects on the repair of cardiovascular diseases. Since these BM-derived stem or progenitor cells contain various angiogenic and neurotrophic factors, these cells have been attempted for treating experimental DN, and turned out to be effective for reversing various manifestations of experimental DN. These evidences suggest that cell therapy, affecting both vascular and neural components, can represent a novel therapeutic option for treatment of clinical DN.

Citations

Citations to this article as recorded by  

• Efficacy of adipose‐derived mesenchymal stem cell therapy in the treatment of chronic micro‐ and macrovascular complications of diabetes
  Agnieszka Mikłosz, Adrian Chabowski
  Diabetes, Obesity and Metabolism.2024; 26(3): 793.     CrossRef
• Interferon-gamma Treatment of Human Umbilical Cord Mesenchymal Stem Cells can Significantly Reduce Damage Associated with Diabetic Peripheral Neuropathy in Mice
  Li-Fen Yang, Jun-Dong He, Wei-Qi Jiang, Xiao-Dan Wang, Xiao-Chun Yang, Zhi Liang, Yi-Kun Zhou
  Current Stem Cell Research & Therapy.2024; 19(8): 1129.     CrossRef
• Natural molecules as promising players against diabetic peripheral neuropathy: an emerging nutraceutical approach
  Rabia Akram, Haseeb Anwar, Muhammad Shahid Javed, Ali Imran, Azhar Rasul, Shoaib Ahmad Malik, Mobina Manzoor, Fakhar Islam, Ikram Ullah Khan, Faiqa Sajid, Tehreem Iman, Muhammad Ajmal Shah, Tao Sun, Ghulam Hussain, Mohd Asif Shah
  International Journal of Food Properties.2023; 26(1): 894.     CrossRef
• A Receptor Story: Insulin Resistance Pathophysiology and Physiologic Insulin Resensitization’s Role as a Treatment Modality
  Stanley T. Lewis, Frank Greenway, Tori R. Tucker, Michael Alexander, Levonika K. Jackson, Scott A. Hepford, Brian Loveridge, Jonathan R. T. Lakey
  International Journal of Molecular Sciences.2023; 24(13): 10927.     CrossRef
• Nanochannel‐Based Poration Drives Benign and Effective Nonviral Gene Delivery to Peripheral Nerve Tissue
  Jordan T. Moore, Christopher G. Wier, Luke R. Lemmerman, Lilibeth Ortega‐Pineda, Daniel J. Dodd, William R. Lawrence, Silvia Duarte‐Sanmiguel, Kavya Dathathreya, Ludmila Diaz‐Starokozheva, Hallie N. Harris, Chandan K. Sen, Ian L. Valerio, Natalia Higuita‐
  Advanced Biosystems.2020;[Epub]     CrossRef
• Endothelial progenitor cells and peripheral neuropathy in subjects with type 2 diabetes mellitus
  Ioanna Eleftheriadou, Natalia Dimitrakopoulou, Nikolitsa Kafasi, Anastasios Tentolouris, Aglaia Dimitrakopoulou, Ioanna A. Anastasiou, Iordanis Mourouzis, Edward Jude, Nikolaos Tentolouris
  Journal of Diabetes and its Complications.2020; 34(4): 107517.     CrossRef
• Autologous Bone Marrow Mononuclear Cell Transplantation Therapy Improved Symptoms in Patients with Refractory Diabetic Sensorimotor Polyneuropathy via the Mechanisms of Paracrine and Immunomodulation: A Controlled Study
  Wei Wei, Li Li, Lin Deng, Zhong-Jing Wang, Jing-Jian Dong, Xiao-Yu Lyu, Ting Jia, Li Wang, Hong-Xiang Wang, Hong Mao, Shi Zhao
  Cell Transplantation.2020; 29: 096368972094925.     CrossRef
• Sodium nitrate preconditioning prevents progression of the neuropathic pain in streptozotocin-induced diabetes Wistar rats
  Hajar Oghbaei, Gisou Mohaddes, GholamReza Hamidian, Rana Keyhanmanesh
  Journal of Diabetes & Metabolic Disorders.2020; 19(1): 105.     CrossRef
• The Influence of Diabetic Foot Exercise in Sensory Peripheral Neuropathy with Monofilament Test on Diabetes Mellitus Clients
  Tintin Sukartini, Candra Panji Asmoro, Nandani Alifah
  Jurnal Ners.2020; 14(3): 340.     CrossRef
• Effects of mesenchymal stromal cells on motor function and collagen in the skeletal muscles of rats with type I diabetes
  Genoveva L. F. Luna, Thiago L. Russo, Maria A. Sabadine, Yisel C. Estrada‐Bonilla, Ana L. M. Andrade, Patricia Brassolatti, Fernanda F. Anibal, Ângela M. O. Leal
  International Journal of Experimental Pathology.2019; 100(5-6): 359.     CrossRef
• Efficacy of autologous bone marrow mononuclear cell transplantation therapy in patients with refractory diabetic peripheral neuropathy
  Hong Mao, Wei Wei, Xiu-Li Fu, Jing-Jian Dong, Xiao-Yu Lyu, Ting Jia, Yang Tang, Shi Zhao
  Chinese Medical Journal.2019; 132(1): 11.     CrossRef
• Effects of adipose derived stromal vascular fraction on diabetic neuropathy: an experimental study
  Berrak Karatan, Ersin Akşam, Esra Erden, Mustafa Erol Demirseren
  Journal of Plastic Surgery and Hand Surgery.2019; 53(6): 335.     CrossRef
• Addressing Stem Cell Therapeutic Approaches in Pathobiology of Diabetes and Its Complications
  Bou-Yue Peng, Navneet Kumar Dubey, Viraj Krishna Mishra, Feng-Chou Tsai, Rajni Dubey, Win-Ping Deng, Hong-Jian Wei
  Journal of Diabetes Research.2018; 2018: 1.     CrossRef
• Transplantation of human mobilized mononuclear cells improved diabetic neuropathy
  Se Hee Min, Jung Hee Kim, Yu Mi Kang, Seung Hak Lee, Byung-Mo Oh, Kyou-Sup Han, Meihua Zhang, Hoe Suk Kim, Woo Kyung Moon, Hakmo Lee, Kyong Soo Park, Hye Seung Jung
  Journal of Endocrinology.2018; 239(3): 277.     CrossRef
• Fluoxetine pretreatment enhances neurogenic, angiogenic and immunomodulatory effects of MSCs on experimentally induced diabetic neuropathy
  Shaimaa A. Abdelrahman, Mai A. Samak, Sally M. Shalaby
  Cell and Tissue Research.2018; 374(1): 83.     CrossRef
• Autologous Bone Marrow-Derived Stem Cells for Treating Diabetic Neuropathy in Metabolic Syndrome
  Wei Liu, Fengchun Yu, Zhenghong Zhou, Yi-Chen Li, Dongsheng Fan, Kai Zhu
  BioMed Research International.2017; 2017: 1.     CrossRef
• Impaired olfactory function is related to the presence of neuropathy in adults with type 1 diabetes
  Anna Duda-Sobczak, Aleksandra Araszkiewicz, Magdalena Urbas, Lukasz Borucki, Katarzyna Kulas, Maciej Chudzinski, Aleksandra Suwalska, Dorota Zozulinska-Ziolkiewicz
  Diabetes and Vascular Disease Research.2017; 14(2): 139.     CrossRef
• New insights into the ameliorative effects of ferulic acid in pathophysiological conditions
  Sumit Ghosh, Priyanka Basak, Sayanta Dutta, Sayantani Chowdhury, Parames C. Sil
  Food and Chemical Toxicology.2017; 103: 41.     CrossRef
• Ferulic acid pretreatment could improve prognosis of autologous mesenchymal stromal cell transplantation for diabetic neuropathy
  Solmaz Mirzamohammadi, Mohammad Hadi Nematollahi, Mehrzad Mehrbani, Mehrnaz Mehrabani
  Cytotherapy.2016; 18(7): 925.     CrossRef
• Mesenchymal stem cells to treat diabetic neuropathy: a long and strenuous way from bench to the clinic
  J Y Zhou, Z Zhang, G S Qian
  Cell Death Discovery.2016;[Epub]     CrossRef
• Diabetes mellitus related bone metabolism and periodontal disease
  Ying-Ying Wu, E Xiao, Dana T Graves
  International Journal of Oral Science.2015; 7(2): 63.     CrossRef
• Microvessel permeability correlates with diabetic peripheral neuropathy in early stage of streptozotocin-induced diabetes rats
  Liyuan Peng, Wei Liu, Fanglong Zhai, Li He, Hailan Wang
  Journal of Diabetes and its Complications.2015; 29(7): 865.     CrossRef
• Mesenchymal Stem Cell-Based Treatment for Microvascular and Secondary Complications of Diabetes Mellitus
  Grace C. Davey, Swapnil B. Patil, Aonghus O’Loughlin, Timothy O’Brien
  Frontiers in Endocrinology.2014;[Epub]     CrossRef
• Emerging roles of hematopoietic cells in the pathobiology of diabetic complications
  Hideto Kojima, Jongoh Kim, Lawrence Chan
  Trends in Endocrinology & Metabolism.2014; 25(4): 178.     CrossRef

Reduction of beta cell function and a beta cell mass is observed in both type 1 and type 2 diabetes. Therefore, restoration of this deficiency might be a therapeutic option for treatment of diabetes. Islet transplantation has benefits, such as reduced incidence of hypoglycemia and achievement of insulin independence. However, the major drawback is an insufficient supply of islet donors. Transplantation of cells differentiated in vitro or in vivo regeneration of insulin-producing cells are possible approaches for beta cell/islet regenerative therapy. Embryonic and adult stem cells, pancreatic ductal progenitor cells, acinar cells, and other endocrine cells have been shown to differentiate into pancreatic beta cells. Formation of fully functional beta cells and the safety of these cells are critical issues for successful clinical application.

Citations

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• The efficiency of stem cell differentiation into functional beta cells for treating insulin-requiring diabetes: Recent advances and current challenges
  Yunfei Luo, Peng Yu, Jianping Liu
  Endocrine.2024; 86(1): 1.     CrossRef
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