The pyruvate dehydrogenase complex (PDC) is an emerging target for the treatment of metabolic syndrome. To maintain a steady-state concentration of adenosine triphosphate during the feed-fast cycle, cells require efficient utilization of fatty acid and glucose, which is controlled by the PDC. The PDC converts pyruvate, coenzyme A (CoA), and oxidized nicotinamide adenine dinucleotide (NAD⁺) into acetyl-CoA, reduced form of nicotinamide adenine dinucleotide (NADH), and carbon dioxide. The activity of the PDC is up- and down-regulated by pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphatase, respectively. In addition, pyruvate is a key intermediate of glucose oxidation and an important precursor for the synthesis of glucose, glycerol, fatty acids, and nonessential amino acids.

Citations

Citations to this article as recorded by  

• Inhibition of Pyruvate Dehydrogenase Kinase 4 Attenuates Myocardial and Mitochondrial Injury in Sepsis-Induced Cardiomyopathy
  Tangtian Chen, Liang Ye, Jing Zhu, Bin Tan, Qin Yi, Yanting Sun, Qiumin Xie, Han Xiang, Rui Wang, Jie Tian, Hao Xu
  The Journal of Infectious Diseases.2024; 229(4): 1178.     CrossRef
• Identification of disease related biomarkers in time varying ‘Omic data: A non-negative matrix factorization aided multi level self organizing map based approach
  Anirban Dey, Kaushik Das Sharma, Pritha Bhattacharjee, Amitava Chatterjee
  Biomedical Signal Processing and Control.2024; 90: 105860.     CrossRef
• Dietary supplementation with probiotics promotes weight loss by reshaping the gut microbiome and energy metabolism in obese dogs
  Anna Kang, Min-Jin Kwak, Daniel Junpyo Lee, Jeong Jae Lee, Min Kyu Kim, Minho Song, Minjee Lee, Jungwoo Yang, Sangnam Oh, Younghoon Kim, Xia Ding
  Microbiology Spectrum.2024;[Epub]     CrossRef
• Acetate circumvents impaired metabolic switch in skeletal muscle of letrozole-induced PCOS rat model by suppression of PDK4/NLRP3
  Kehinde S. Olaniyi, Stephanie E. Areloegbe
  Nutrition.2023; 107: 111914.     CrossRef
• The Link between Mitochondrial Dysfunction and Sarcopenia: An Update Focusing on the Role of Pyruvate Dehydrogenase Kinase 4
  Min-Ji Kim, Ibotombi Singh Sinam, Zerwa Siddique, Jae-Han Jeon, In-Kyu Lee
  Diabetes & Metabolism Journal.2023; 47(2): 153.     CrossRef
• Mitochondrial pyruvate dehydrogenase kinases contribute to platelet function and thrombosis in mice by regulating aerobic glycolysis
  Gagan D. Flora, Manasa K. Nayak, Madankumar Ghatge, Mariia Kumskova, Rakesh B. Patel, Anil K. Chauhan
  Blood Advances.2023; 7(11): 2347.     CrossRef
• Inhibition of pyruvate dehydrogenase kinase 4 ameliorates kidney ischemia-reperfusion injury by reducing succinate accumulation during ischemia and preserving mitochondrial function during reperfusion
  Chang Joo Oh, Min-Ji Kim, Ji-Min Lee, Dong Hun Kim, Il-Young Kim, Sanghee Park, Yeongmin Kim, Kyung-Bok Lee, Sang-Hee Lee, Chae Won Lim, Myeongjin Kim, Jung-Yi Lee, Haushabhau S. Pagire, Suvarna H. Pagire, Myung Ae Bae, Dipanjan Chanda, Themis Thoudam, Ah
  Kidney International.2023; 104(4): 724.     CrossRef
• Key enzyme in charge of ketone reabsorption of renal tubular SMCT1 may be a new target in diabetic kidney disease
  Zhenhong Guo, Feifei Zhong, Meng Hou, Jinlan Xie, A Zhong Zhang, Xinran Li, Yuan Li, Baocheng Chang, Juhong Yang
  Nephrology Dialysis Transplantation.2023; 38(12): 2754.     CrossRef
• ERRα fosters running endurance by driving myofiber aerobic transformation and fuel efficiency
  Hui Xia, Charlotte Scholtes, Catherine R. Dufour, Christina Guluzian, Vincent Giguère
  Molecular Metabolism.2023; 78: 101814.     CrossRef
• Epigenetic Aspects of a New Probiotic Concept—A Pilot Study
  Nina Okuka, Verena Schuh, Ulrike Krammer, Snezana Polovina, Mirjana Sumarac-Dumanovic, Neda Milinkovic, Ksenija Velickovic, Brizita Djordjevic, Alexander Haslberger, Nevena Dj. Ivanovic
  Life.2023; 13(9): 1912.     CrossRef
• Gene Expression Analyses in Models of Rosiglitazone-Induced Physiological and Pathological Mineralization Identify Novel Targets to Improve Bone and Vascular Health
  Claudia Bruedigam, Johannes P. T. M. van Leeuwen, Jeroen van de Peppel
  Cells.2023; 12(20): 2462.     CrossRef
• PDK4 rescues high-glucose-induced senescent fibroblasts and promotes diabetic wound healing through enhancing glycolysis and regulating YAP and JNK pathway
  Zhouji Ma, Youjun Ding, Xiaofeng Ding, Haining Mou, Ran Mo, Qian Tan
  Cell Death Discovery.2023;[Epub]     CrossRef
• MicroRNA-148a-3p in pericyte-derived extracellular vesicles improves erectile function in diabetic mice by promoting cavernous neurovascular regeneration
  Jiyeon Ock, Fang-Yuan Liu, Fitri Rahma Fridayana, Lashkari Niloofar, Minh Nhat Vo, Yan Huang, Shuguang Piao, Tie Zhou, Yin Guonan
  BMC Urology.2023;[Epub]     CrossRef
• Serum metabolites associated with increased insulin resistance and low cardiorespiratory fitness in overweight adolescents
  Renata G. Duft, Alex Castro, Ivan L.P. Bonfante, Wendell A. Lopes, Larissa R. da Silva, Mara P.T. Chacon-Mikahil, Neiva Leite, Cláudia R. Cavaglieri
  Nutrition, Metabolism and Cardiovascular Diseases.2022; 32(1): 269.     CrossRef
• Metabolic tricks of cancer cells
  Katerina Hönigova, Jiri Navratil, Barbora Peltanova, Hana Holcova Polanska, Martina Raudenska, Michal Masarik
  Biochimica et Biophysica Acta (BBA) - Reviews on Cancer.2022; 1877(3): 188705.     CrossRef
• Insulin action and resistance are dependent on a GSK3β-FBXW7-ERRα transcriptional axis
  Hui Xia, Charlotte Scholtes, Catherine R. Dufour, Carlo Ouellet, Majid Ghahremani, Vincent Giguère
  Nature Communications.2022;[Epub]     CrossRef
• Bayesian nonparametric modelling of multiple graphs with an application to ethnic metabolic differences
  Marco Molinari, Andrea Cremaschi, Maria De Iorio, Nishi Chaturvedi, Alun D. Hughes, Therese Tillin
  Journal of the Royal Statistical Society: Series C (Applied Statistics).2022; 71(5): 1181.     CrossRef
• Celastrol alleviates high-fat diet-induced obesity via enhanced muscle glucose utilization and mitochondrial oxidative metabolism-mediated upregulation of pyruvate dehydrogenase complex
  Mohamad Hafizi Abu Bakar, Nor Shafiqah Nor Shahril, Mohamad Shamil Faris Mohamad Khalid, Sharifah Mohammad, Khairul Anuar Shariff, Thiruventhan Karunakaran, Rabeta Mohd Salleh, Mohamad Norisham Mohamad Rosdi
  Toxicology and Applied Pharmacology.2022; 449: 116099.     CrossRef
• Role of branched-chain amino acid metabolism in the pathogenesis of obesity and type 2 diabetes-related metabolic disturbances BCAA metabolism in type 2 diabetes
  Froukje Vanweert, Patrick Schrauwen, Esther Phielix
  Nutrition & Diabetes.2022;[Epub]     CrossRef
• Urine Metabolomics Reveals Overlapping Metabolic Associations Between Preeclampsia and Gestational Diabetes
  Nupur Rani Agarwal, Garima Kachhawa, Bolaji Fatai Oyeyemi, Neel Sarovar Bhavesh
  Indian Journal of Clinical Biochemistry.2022;[Epub]     CrossRef
• Early-life stress altered pancreatic Krebs cycle-related enzyme activities in response to young adulthood physical and psychological stress in male rat offspring
  Mina Salimi, Forouzan Sadeghimahalli, Fatemeh Shaerzadeh, Fariba Khodagholi, Homeira Zardooz
  Hormone Molecular Biology and Clinical Investigation.2021; 42(1): 19.     CrossRef
• Hyperglycemia and gestational diabetes suppress placental glycolysis and mitochondrial function and alter lipid processing
  Amy M. Valent, Haeri Choi, Kevin S. Kolahi, Kent L. Thornburg
  The FASEB Journal.2021;[Epub]     CrossRef
• Novel and emerging therapeutic drug targets for management of type 2 Diabetes Mellitus
  Prateek Sharma, Sukhbir Singh, Vinay Thakur, Neelam Sharma, Ajmer Singh Grewal
  Obesity Medicine.2021; 23: 100329.     CrossRef
• Macronutrient Determinants of Obesity, Insulin Resistance and Metabolic Health
  Jibran A. Wali, Samantha M. Solon-Biet, Therese Freire, Amanda E. Brandon
  Biology.2021; 10(4): 336.     CrossRef
• Bioenergetic and Proteomic Profiling of Immune Cells in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients: An Exploratory Study
  Paula Fernandez-Guerra, Ana C. Gonzalez-Ebsen, Susanne E. Boonen, Julie Courraud, Niels Gregersen, Jesper Mehlsen, Johan Palmfeldt, Rikke K. J. Olsen, Louise Schouborg Brinth
  Biomolecules.2021; 11(7): 961.     CrossRef
• Carnosine protects stimulus-secretion coupling through prevention of protein carbonyl adduction events in cells under metabolic stress
  Charlie Jr Lavilla, Merell P. Billacura, Katie Hanna, David J. Boocock, Clare Coveney, Amanda K. Miles, Gemma A. Foulds, Alice Murphy, Arnold Tan, Laura Jackisch, Sophie R. Sayers, Paul W. Caton, Craig L. Doig, Philip G. McTernan, Sergio L. Colombo, Craig
  Free Radical Biology and Medicine.2021; 175: 65.     CrossRef
• Altered metabolomic profiling of overweight and obese adolescents after combined training is associated with reduced insulin resistance
  Renata G. Duft, Alex Castro, Ivan L. P. Bonfante, Wendell A. Lopes, Larissa R. da Silva, Mara P. T. Chacon-Mikahil, Neiva Leite, Cláudia R. Cavaglieri
  Scientific Reports.2020;[Epub]     CrossRef
• Moderate Aerobic Exercise Training Prevents the Augmented Hepatic Glucocorticoid Response Induced by High-Fat Diet in Mice
  Jonatan Dassonvalle, Francisco Díaz-Castro, Camila Donoso-Barraza, Carlos Sepúlveda, Francisco Pino-de la Fuente, Pamela Pino, Alejandra Espinosa, Mario Chiong, Miguel Llanos, Rodrigo Troncoso
  International Journal of Molecular Sciences.2020; 21(20): 7582.     CrossRef
• The Implications of PDK1–4 on Tumor Energy Metabolism, Aggressiveness and Therapy Resistance
  Emine Atas, Monika Oberhuber, Lukas Kenner
  Frontiers in Oncology.2020;[Epub]     CrossRef
• Redox-Driven Signaling: 2-Oxo Acid Dehydrogenase Complexes as Sensors and Transmitters of Metabolic Imbalance
  Victoria I. Bunik
  Antioxidants & Redox Signaling.2019; 30(16): 1911.     CrossRef
• Myocardial Adaptation in Pseudohypoxia: Signaling and Regulation of mPTP via Mitochondrial Connexin 43 and Cardiolipin
  Miroslav Ferko, Natália Andelová, Barbara Szeiffová Bačová, Magdaléna Jašová
  Cells.2019; 8(11): 1449.     CrossRef
• Mitochondrial Uncoupling Coordinated With PDH Activation Safely Ameliorates Hyperglycemia via Promoting Glucose Oxidation
  Haowen Jiang, Jia Jin, Yanan Duan, Zhifu Xie, Yufeng Li, Anhui Gao, Min Gu, Xinwen Zhang, Chang Peng, Chunmei Xia, Tiancheng Dong, Hui Li, Lifang Yu, Jie Tang, Fan Yang, Jingya Li, Jia Li
  Diabetes.2019; 68(12): 2197.     CrossRef
• Effects of intermittent hypoxia training on leukocyte pyruvate dehydrogenase kinase 1 (PDK-1) mRNA expression and blood insulin level in prediabetes patients
  Tetiana V. Serebrovska, Alla G. Portnychenko, Vladimir I. Portnichenko, Lei Xi, Egor Egorov, Ivanna Antoniuk-Shcheglova, Svitlana Naskalova, Valeriy B. Shatylo
  European Journal of Applied Physiology.2019; 119(3): 813.     CrossRef
• Avocatin B Protects Against Lipotoxicity and Improves Insulin Sensitivity in Diet‐Induced Obesity
  Nawaz Ahmed, Matthew Tcheng, Alessia Roma, Michael Buraczynski, Preethi Jayanth, Kevin Rea, Tariq A. Akhtar, Paul A. Spagnuolo
  Molecular Nutrition & Food Research.2019;[Epub]     CrossRef
• Discovery of Novel Pyruvate Dehydrogenase Kinase 4 Inhibitors for Potential Oral Treatment of Metabolic Diseases
  Dahye Lee, Haushabhau S. Pagire, Suvarna H. Pagire, Eun Jung Bae, Mahesh Dighe, Minhee Kim, Kyu Myung Lee, Yoon Kyung Jang, Ashok Kumar Jaladi, Kwan-Young Jung, Eun Kyung Yoo, Hee Eon Gim, Seungmi Lee, Won-Il Choi, Young-In Chi, Jin Sook Song, Myung Ae Ba
  Journal of Medicinal Chemistry.2019; 62(2): 575.     CrossRef
• Therapeutic effect of dichloroacetate against atherosclerosis via hepatic FGF21 induction mediated by acute AMPK activation
  Byong-Keol Min, Chang Joo Oh, Sungmi Park, Ji-Min Lee, Younghoon Go, Bo-Yoon Park, Hyeon-Ji Kang, Dong Wook Kim, Jeong-Eun Kim, Eun Kyung Yoo, Hui Eon Kim, Mi-Jin Kim, Yong Hyun Jeon, Yong-Hoon Kim, Chul-Ho Lee, Jae-Han Jeon, In-Kyu Lee
  Experimental & Molecular Medicine.2019; 51(10): 1.     CrossRef
• Identification of Novel Resorcinol Amide Derivatives as Potent and Specific Pyruvate Dehydrogenase Kinase (PDHK) Inhibitors
  Hanna Cho, Injae Shin, Kyungseon Cho, Hojong Yoon, Eun Kyung Yoo, Mi-Jin Kim, Sungmi Park, In-Kyu Lee, Nam Doo Kim, Taebo Sim
  Journal of Medicinal Chemistry.2019; 62(18): 8461.     CrossRef
• Enzymes inhibitors from natural sources with antidiabetic activity: A review
  Fiaz Alam, Zainab Shafique, Sayyeda Tayyeba Amjad, Mohammad Hassham Hassan Bin Asad
  Phytotherapy Research.2019; 33(1): 41.     CrossRef
• Pyruvate Dehydrogenase Kinase Is a Metabolic Checkpoint for Polarization of Macrophages to the M1 Phenotype
  Byong-Keol Min, Sungmi Park, Hyeon-Ji Kang, Dong Wook Kim, Hye Jin Ham, Chae-Myeong Ha, Byung-Jun Choi, Jung Yi Lee, Chang Joo Oh, Eun Kyung Yoo, Hui Eon Kim, Byung-Gyu Kim, Jae-Han Jeon, Do Young Hyeon, Daehee Hwang, Yong-Hoon Kim, Chul-Ho Lee, Taeho Lee
  Frontiers in Immunology.2019;[Epub]     CrossRef
• Changes in Host Response to Mycobacterium tuberculosis Infection Associated With Type 2 Diabetes: Beyond Hyperglycemia
  Cristian Alfredo Segura-Cerda, Wendy López-Romero, Mario Alberto Flores-Valdez
  Frontiers in Cellular and Infection Microbiology.2019;[Epub]     CrossRef
• Warburg effect hypothesis in autism Spectrum disorders
  Alexandre Vallée, Jean-Noël Vallée
  Molecular Brain.2018;[Epub]     CrossRef
• How phosphorylation influences E1 subunit pyruvate dehydrogenase: A computational study
  Jacopo Sgrignani, JingJing Chen, Andrea Alimonti, Andrea Cavalli
  Scientific Reports.2018;[Epub]     CrossRef
• Acute activation of pyruvate dehydrogenase increases glucose oxidation in muscle without changing glucose uptake
  Lewin Small, Amanda E. Brandon, Lake-Ee Quek, James R. Krycer, David E. James, Nigel Turner, Gregory J. Cooney
  American Journal of Physiology-Endocrinology and Metabolism.2018; 315(2): E258.     CrossRef
• Molecular Cloning and Expression Analysis of HbPDK of Hevea brasiliensis
  江华 阳
  Botanical Research.2018; 07(05): 528.     CrossRef
• Exercise induces muscle fiber type switching via transient receptor potential melastatin 2-dependent Ca2+ signaling
  Seo-Ho Lee, Byung-Ju Kim, Dae-Ryoung Park, Uh-Hyun Kim
  Journal of Applied Physiology.2018; 124(2): 364.     CrossRef
• Activation de la glycolyse aérobie par la voie canonique WNT/β-caténine
  Alexandre Vallée
  médecine/sciences.2018; 34(4): 326.     CrossRef
• Thermodynamics in Neurodegenerative Diseases: Interplay Between Canonical WNT/Beta-Catenin Pathway–PPAR Gamma, Energy Metabolism and Circadian Rhythms
  Alexandre Vallée, Yves Lecarpentier, Rémy Guillevin, Jean-Noël Vallée
  NeuroMolecular Medicine.2018; 20(2): 174.     CrossRef
• Aerobic glycolysis in amyotrophic lateral sclerosis and Huntington’s disease
  Alexandre Vallée, Yves Lecarpentier, Rémy Guillevin, Jean-Noël Vallée
  Reviews in the Neurosciences.2018; 29(5): 547.     CrossRef
• The Cladophora glomerata Enriched by Biosorption Process in Cr(III) Improves Viability, and Reduces Oxidative Stress and Apoptosis in Equine Metabolic Syndrome Derived Adipose Mesenchymal Stromal Stem Cells (ASCs) and Their Extracellular Vesicles (MV’s)
  Krzysztof Marycz, Izabela Michalak, Ievgeniia Kocherova, Monika Marędziak, Christine Weiss
  Marine Drugs.2017; 15(12): 385.     CrossRef
• Thermodynamics in cancers: opposing interactions between PPAR gamma and the canonical WNT/beta‐catenin pathway
  Yves Lecarpentier, Victor Claes, Alexandre Vallée, Jean‐Louis Hébert
  Clinical and Translational Medicine.2017;[Epub]     CrossRef
• Interactions between PPAR Gamma and the Canonical Wnt/Beta-Catenin Pathway in Type 2 Diabetes and Colon Cancer
  Yves Lecarpentier, Victor Claes, Alexandre Vallée, Jean-Louis Hébert
  PPAR Research.2017; 2017: 1.     CrossRef
• Small heterodimer partner (SHP) deficiency protects myocardia from lipid accumulation in high fat diet-fed mice
  Jung Hun Ohn, Ji Yeon Hwang, Min Kyong Moon, Hwa Young Ahn, Hwan Hee Kim, Young Do Koo, Kwang-Il Kim, Hyuk Jae Chang, Hye Seung Lee, Hak Chul Jang, Young Joo Park, Catherine Mounier
  PLOS ONE.2017; 12(10): e0186021.     CrossRef
• Thermodynamics in Gliomas: Interactions between the Canonical WNT/Beta-Catenin Pathway and PPAR Gamma
  Alexandre Vallée, Yves Lecarpentier, Rémy Guillevin, Jean-Noël Vallée
  Frontiers in Physiology.2017;[Epub]     CrossRef
• Early-onset and classical forms of type 2 diabetes show impaired expression of genes involved in muscle branched-chain amino acids metabolism
  María Isabel Hernández-Alvarez, Angels Díaz-Ramos, María Berdasco, Jeff Cobb, Evarist Planet, Diane Cooper, Agnieszka Pazderska, Krzystof Wanic, Declan O’Hanlon, Antonio Gomez, Laura R. de la Ballina, Manel Esteller, Manuel Palacin, Donal J. O’Gorman, Joh
  Scientific Reports.2017;[Epub]     CrossRef
• Diabetes-Related Cardiac Dysfunction
  Lamario J. Williams, Brenna G. Nye, Adam R. Wende
  Endocrinology and Metabolism.2017; 32(2): 171.     CrossRef
• Pyruvate dehydrogenase kinase 4 deficiency attenuates cisplatin-induced acute kidney injury
  Chang Joo Oh, Chae-Myeong Ha, Young-Keun Choi, Sungmi Park, Mi Sun Choe, Nam Ho Jeoung, Yang Hoon Huh, Hyo-Jeong Kim, Hee-Seok Kweon, Ji-min Lee, Sun Joo Lee, Jae-Han Jeon, Robert A. Harris, Keun-Gyu Park, In-Kyu Lee
  Kidney International.2017; 91(4): 880.     CrossRef
• Black Adzuki Bean (Vigna angularis) Extract Protects Pancreatic β Cells and Improves Glucose Tolerance in C57BL/6J Mice Fed a High-Fat Diet
  Mina Kim, Dae Keun Kim, Youn-Soo Cha
  Journal of Medicinal Food.2016; 19(5): 442.     CrossRef
• Pyruvate dehydrogenase kinase regulates hepatitis C virus replication
  Gwon-Soo Jung, Jae-Han Jeon, Yeon-Kyung Choi, Se Young Jang, Soo Young Park, Sung-Woo Kim, Jun-Kyu Byun, Mi-Kyung Kim, Sungwoo Lee, Eui-Cheol Shin, In-Kyu Lee, Yu Na Kang, Keun-Gyu Park
  Scientific Reports.2016;[Epub]     CrossRef
• 1α,25-Dihydroxyvitamin D3 Regulates Mitochondrial Oxygen Consumption and Dynamics in Human Skeletal Muscle Cells
  Zachary C. Ryan, Theodore A. Craig, Clifford D. Folmes, Xuewei Wang, Ian R. Lanza, Niccole S. Schaible, Jeffrey L. Salisbury, K. Sreekumaran Nair, Andre Terzic, Gary C. Sieck, Rajiv Kumar
  Journal of Biological Chemistry.2016; 291(3): 1514.     CrossRef
• Computational Study on New Natural Compound Inhibitors of Pyruvate Dehydrogenase Kinases
  Xiaoli Zhou, Shanshan Yu, Jing Su, Liankun Sun
  International Journal of Molecular Sciences.2016; 17(3): 340.     CrossRef
• Dynamic gene expression profiles during postnatal development of porcine subcutaneous adipose
  Jie Zhang, Jideng Ma, Keren Long, Long Jin, Yihui Liu, Chaowei Zhou, Shilin Tian, Lei Chen, Zonggang Luo, Qianzi Tang, An’an Jiang, Xun Wang, Dawei Wang, Zhi Jiang, Jinyong Wang, Xuewei Li, Mingzhou Li
  PeerJ.2016; 4: e1768.     CrossRef
• Mechanisms of Vascular Calcification: The Pivotal Role of Pyruvate Dehydrogenase Kinase 4
  Jaechan Leem, In-Kyu Lee
  Endocrinology and Metabolism.2016; 31(1): 52.     CrossRef
• An Untargeted Metabolomics Analysis of Antipsychotic Use in Bipolar Disorder
  Kyle J. Burghardt, Simon J. Evans, Kristen M. Wiese, Vicki L. Ellingrod
  Clinical and Translational Science.2015; 8(5): 432.     CrossRef
• Altered liver expression of genes involved in lipid and glucose metabolism in mice with partial IGF-1 deficiency: an experimental approach to metabolic syndrome
  J. Rodríguez De Ita, I. Castilla-Cortázar, G. A. Aguirre, C. Sánchez-Yago, M. Olleros Santos-Ruiz, L. Guerra-Menéndez, I. Martín-Estal, M. García-Magariño, V. J. Lara-Díaz, J. E. Puche, U. Muñoz
  Journal of Translational Medicine.2015;[Epub]     CrossRef