Diabetes & Metabolism Journal

Original Articles

Metabolic Risk/Epidemiology
Glucose-Independent Metabolic Signatures of SGLT2 Inhibition in Diabetic Kidney Disease: Integrated Insights from Mendelian Randomization and Transcriptomics: Yang Zhou, Jie Peng, Xuchang Zhou, Yucheng Wang, Guolin Hong, Xinguo Zhuang; Received December 16, 2025 Accepted March 18, 2026 Published online August 7, 2026; DOI: https://doi.org/10.4093/dmj.2025.1273 [Epub ahead of print]

1,590 View
33 Download

Abstract PDF Supplementary Material PubReader ePub: Background
Diabetic kidney disease (DKD) remains a major cause of terminal renal failure, with residual risk remaining unacceptably high despite standard glucose control. Although the sodium-glucose co-transporter 2 (SGLT2) inhibitors have proven reno-protective properties extending beyond that explained by glucose lowering alone, unique glucose-independent molecular mechanisms are still incompletely defined. Unveiling these non-glycemic metabolic pathways is of paramount importance for new therapeutic targets and optimized clinical management.
Methods
A systematic multi-omics triangulation framework integrating Mendelian randomization (MR) with tissue-specific transcriptomics was conducted. Two-sample MR and multivariable Mendelian randomization (MVMR) adjusted for fasting blood glucose were leveraged as a screening tool to detect glucose-independent serum metabolites in humans using large-scale genome-wide association study data. These findings were validated with transcriptomic signatures from both diabetic and non-diabetic mouse kidney models to identify conserved core genes and convergent metabolic pathways.
Results
Genetically proxied SGLT2 inhibition associated with a reduced risk of DKD, with an odds ratio of 0.58, and improved renal function markers. MVMR highlighted 259 glucose-independent metabolites, covering systemic alterations in lipid and amino acid metabolism. A cross-model transcriptomic comparison revealed seven key genes functionally enriched in fatty acid oxidation and ketone body utilization. This convergence supports the concept of a fasting-like metabolic switch and coordinated downregulation of fibrosis-related extracellular matrix pathways irrespective of diabetic status.
Conclusion
This study delineates a systemic-renal metabolic axis whereby SGLT2 inhibition drives renoprotection via metabolic reprogramming and anti-fibrotic mechanisms distinct from blood glucose lowering. These findings provide genetic evidence for specific non-glycemic targets and represent a novel mechanistic insight for precision therapeutic intervention in kidney disease.

Complications
Optimizing Early Detection of Diabetic Kidney Disease through Synergistic Biomarkers and Serum Metabolites in Humans: Xianke Zhou, Yuan Gui, Jia-Jun Liu, Shijia Liu, Dongning Liang, Yuanyuan Wang, Henry Wells Shaffer, Samantha Mae Mallari, Cameron Jones, Priya Gupta, Dier Li, Ke Zhang, Ying Yu, Jianling Tao, Yanlin Wang, Silvia Liu, Dong Zhou, Haiyan Fu; Diabetes Metab J. 2026;50(4):752-769. Published online January 29, 2026; DOI: https://doi.org/10.4093/dmj.2025.0193

5,013 View
168 Download
3 Web of Science
3 Crossref

Abstract PDF Supplementary Material PubReader ePub

Background
Diabetic kidney disease (DKD) often progresses to end-stage renal disease more rapidly than nondiabetic kidney disease because of persistent hyperglycemia and early activation of multiple pathogenic pathways. Early detection of DKD is crucial for identifying subtle kidney damage before clinical symptoms appear.
Methods
This study combined human serum proteomics with public single-cell RNA sequencing and spatial transcriptomics data from diabetic kidneys to identify key biomarkers for DKD diagnosis. These biomarkers were validated in multiple organs of db/db mice at early and advanced stages. In a discovery cohort, sera from 173 healthy adults and 444 patients with type 2 diabetes mellitus (T2DM), with or without kidney disease, were analyzed using metabolomics and enzyme-linked immunosorbent assay (ELISA). Multiple machine learning algorithms were developed to integrate synergistic biomarkers and serum metabolites for early DKD detection, with results validated in 435 participants from four independent clinical cohorts.
Results
Metalloproteinase-7 (MMP-7) and tenascin C (TNC) were elevated in human diabetic kidneys at the single-cell and spatial levels. Proteomics indicated upregulation of serum amyloid A1 (SAA1) and TNC in the serum of patients with DKD. In db/db mice, all three biomarkers increased in multiple organs by 18 weeks of age. In sera from patients with DKD, MMP-7 and TNC levels were consistently elevated across cohorts. The new algorithms combining MMP-7, SAA1, and TNC enhanced early-stage DKD detection, with approximately 13% improvements in accuracy when serum metabolites were included to distinguish progression from early to advanced DKD stages.
Conclusion
Integrating synergistic biomarkers with serum metabolomics enhances the early detection of DKD, potentially improving outcomes by slowing disease progression in patients with T2DM.

Citations

Citations to this article as recorded by

Recent advances in point-of-care colorimetric biosensors for detecting small molecule metabolites
Zhiqiang Zhu, Zhun Gu, Xinxing Cao, Shanshan Zhang, Shao Su
Chemical Communications.2026; 62(48): 12000. CrossRef
Pathology-Anchored Biomarker Research Progress for the Early Diagnosis of Diabetic Kidney Disease: From Pathological Association to Early Validation
Qiu Li, Mei Yang, Yingyu Luo, Nannan Zhang
Biomedicines.2026; 14(7): 1643. CrossRef
A hypoxia-derived seven-gene signature reflects immune remodeling in diabetic kidney disease: integrated transcriptomic analysis and experimental validation
Yue Ji, Jiakun Zhang, Xi Guo, Yunming Xiao, Tieshan Wang, Yifei Zhang, Zhixun Guo, Yuqi Wu, Liangzhen You, Wei Jing Liu
Diabetes Research and Clinical Practice.2026; 241: 113568. CrossRef

Review

Complications
Pathophysiologic Mechanisms and Potential Biomarkers in Diabetic Kidney Disease: Chan-Young Jung, Tae-Hyun Yoo; Diabetes Metab J. 2022;46(2):181-197. Published online March 24, 2022; DOI: https://doi.org/10.4093/dmj.2021.0329

46,308 View
1,631 Download
233 Web of Science
249 Crossref

Abstract PDF PubReader ePub

Although diabetic kidney disease (DKD) remains the leading cause of end-stage kidney disease eventually requiring chronic kidney replacement therapy, the prevalence of DKD has failed to decline over the past 30 years. In order to reduce disease prevalence, extensive research has been ongoing to improve prediction of DKD onset and progression. Although the most commonly used markers of DKD are albuminuria and estimated glomerular filtration rate, their limitations have encouraged researchers to search for novel biomarkers that could improve risk stratification. Considering that DKD is a complex disease process that involves several pathophysiologic mechanisms such as hyperglycemia induced inflammation, oxidative stress, tubular damage, eventually leading to kidney damage and fibrosis, many novel biomarkers that capture one specific mechanism of the disease have been developed. Moreover, the increasing use of high-throughput omic approaches to analyze biological samples that include proteomics, metabolomics, and transcriptomics has emerged as a strong tool in biomarker discovery. This review will first describe recent advances in the understanding of the pathophysiology of DKD, and second, describe the current clinical biomarkers for DKD, as well as the current status of multiple potential novel biomarkers with respect to protein biomarkers, proteomics, metabolomics, and transcriptomics.

Citations

Citations to this article as recorded by

Integrative network pharmacology and machine learning identify coagulation–inflammation hub targets of Jinkui Shenqi Pill in diabetic kidney disease: molecular docking and molecular dynamics/MM/GBSA analysis of quercetin binding to PAR1 and tissue factor
Yao Xu, Qingying Tan, Tianxiao Hu, Yanxia Ren, Jiaqi Yao, Xiujing Wang, Yingchun Pan, Peiwu Jiang
Journal of Molecular Structure.2027; 1381: 147628. CrossRef
Diabetic kidney disease: exploring mechanistic depths and the future of pharmacological intervention
Pratik Shankar Rakshe, Anil Bhanudas Gaikwad
Naunyn-Schmiedeberg's Archives of Pharmacology.2026; 399(2): 1625. CrossRef
Metabolic reprogramming in diabetes and other endocrine and metabolic disorders: exploring the Warburg effect, ketones, and SGLT2 inhibitors
Pedro Carrera-Bastos, Marcel H. A. Muskiet, Fernando Mata-Ordoñez, Leo Pruimboom, Alejandro Lucia, Raul M. Luque, Frits A. J. Muskiet
Reviews in Endocrine and Metabolic Disorders.2026; 27(1): 69. CrossRef
Andrographolide alleviates type 2 diabetic nephropathy through suppressing PI3K/AKT1/RRM2-triggered oxeiptosis
Mingzheng Han, Jingchun Wang, Shuaihao Guo, Heyun Zhu, Lijiao Zhao, Ziqi Wu, Yijin Wu, Jianying Guo, Jianzhao Liao, Zhaoxin Tang
Journal of Advanced Research.2026; 85: 1051. CrossRef
β-sitosterol potential against chronic hyperglycemia induced diabetic nephropathy: A dual approach using computational and in-vivo studies
Sachin Sharma, Manjusha Choudhary, Jeevan K, Onkar Sharma, Hari Kishan, Ashwani Mittal
Journal of Ethnopharmacology.2026; 357: 120934. CrossRef
Diabetic peripheral neuropathy as measured using a point‐of‐care sural nerve conduction device is associated with a faster decline in renal function in patients with type 2 diabetes
Tatsuya Fukuda, Akiko Fujii, Taro Akihisa, Naoya Otsubo, Tetsuya Yamada, Chisato Maki
Journal of Diabetes Investigation.2026; 17(2): 291. CrossRef
Duration-dependent alterations of lipid profiles and microvascular complications in GCK-MODY
Yadi Huang, Yuxin Fan, Yang Liu, Xuan Liu, Wei Li, Ying Yang, Ziyue Zhang, Shifeng Ma, Shuhui Ji, Shanshan Chen, Hua Shu, Wenli Feng, Kunling Wang, Qing He, Wenjun Qi, Ming Liu, Xin Li, Yu Fan
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2026; 1872(3): 168137. CrossRef
Extracellular vesicles in diabetic kidney disease: Emerging mechanisms, therapeutic implications, and biomarker prospects
Yang Yu, Yunjie Shan, Anjie Ding, Hui Qian
Biochemical Pharmacology.2026; 244: 117605. CrossRef
S-methylmethionine ameliorates renal injury in diabetic mice by modulating macrophage inflammaging via ERK/NF-κb signaling pathway
Hao Dong, Linjie Shen, Pawuziya Abulizi, Yuezhang Sun, Lulingxiao Nie, Aimin Cui, Qian Fu, Ning Ji, Yuwen Luo, Chienshan Chen, Aimin Xu, Wai Keung Leung, Qi Wang
International Immunopharmacology.2026; 170: 116038. CrossRef
A non-invasive urinary diagnostic signature for diabetic kidney disease revealed by machine learning and single-cell analysis
Yonggang Chen, Jintai Luo, Yingying Zheng, Xiaomei Jiang, Zixiang Yang, Xiaobing Liu, Yusuf Oloruntoyin Ayipo
PLOS One.2026; 21(1): e0340096. CrossRef
Emerging technologies for early risk stratification and precision management of diabetic kidney disease: a multimodal framework integrating digital phenotypes and clinical biomarkers
Lingdong Meng, Zhen Li, Ling Xu, Fang Wei, Hongyan Ji, Lankun Zhang, Anning Zhu, Zhijia Zhou
Frontiers in Endocrinology.2026;[Epub] CrossRef
Glycerol-selective biosensor and microbial biofuel cell based on recombinant yeast and glycerol dehydrogenase nanocomposite
Nataliya Stasyuk, Andriy Zakalskiy, Daria Larowska-Zarych, Oksana Zakalska, Susanna Kushnir, Iryna Slyvka, Olha Demkiv, Sylwester Gawinkowski, Marcin Holdynski, Wojciech Nogala, Mykhailo Gonchar
Microchemical Journal.2026; 221: 116853. CrossRef
C‐X‐C Motif Chemokine Ligand 3 as a Potential Biomarker for Diagnosis and Prognosis of Diabetic Kidney Disease
Sensen Su, Xin Chen, Li Zhang, Hui Yu, Han Qin, Lin Li, Zhanchuan Ma, Yinyu Yu, Zhonggao Xu, Huanfa Yi
The FASEB Journal.2026;[Epub] CrossRef
The triglyceride-high-density lipoprotein-glucose-body index: a superior novel biomarker for diabetic kidney disease in type 2 diabetes
Jian Yang, Bingsong Xie, Zhiling Deng, Zhifu Zhang, Hairong Zhou
Frontiers in Endocrinology.2026;[Epub] CrossRef
Diabetic kidney disease, biomarkers, and finerenone
Ashish Verma, Ashish Upadhyay
Diabetes, Obesity and Metabolism.2026; 28(4): 2582. CrossRef
Functional Molecular Plasma Biomarkers of Inflammation and Repair in Kidney Disease Progression in Gum Arabica Modality of CKD
Sameeha AlShelleh, Maysa Suyagh, Hussein Alhawari, Nailya Bulatova, Violet Kasabri, Ayman Wahbeh, Izzat Alawwa, Ashraf Oweis, Haneen Mustafa
International Journal of Molecular Sciences.2026; 27(2): 973. CrossRef
Integrated Transcriptomic Analysis Identifies TAP1 as a Key Regulator of PANoptosis in Diabetic Kidney Disease Tubular Injury
Qingsong Chen, Hongxuan He, Gang Wang, Lili Huang, Jiakun Yang, Yan Sun, Zheng Zhang, Xiaohui Liao
Inflammation.2026;[Epub] CrossRef
Network Pharmacology Prediction and Molecular Docking Validation of Active Components of Atractylodes macrocephala in Intervening Diabetic Nephropathy
新宇刘
Journal of Clinical Personalized Medicine.2026; 05(01): 414. CrossRef
Integrated network pharmacology and bioinformatics analysis reveals MME as key target of Notoginsenoside R1 in diabetic nephropathy
Xinyu Gan, Mingzhu Liang, Halinuer Shadekejiang, Huan Hong, Jinyu Lu, Xu Li, Xueqin Zhang, Chen Lu
BMC Complementary Medicine and Therapies.2026;[Epub] CrossRef
Characterization of gut microbiota in patients with diabetic kidney disease
Shoujuan Yu, Huimin Niu, Yan Zhang, Ling Yu, Qi Zhang, Xingchen Liu, Yue Sang, Ran Wang, Min Zhang
Frontiers in Cellular and Infection Microbiology.2026;[Epub] CrossRef
Connecting glycation and lipotoxicity to mitochondrial dysfunction in diabetic kidney disease: A ‘tubulocentric’ perspective
Mayura Apte, Girish Kumthekar, Rashmi Santosh Tupe
Biochemical and Biophysical Research Communications.2026; 809: 153479. CrossRef
Changes of retinal microvascular parameters in patients with type 2 diabetes mellitus with or without diabetic kidney disease
Ruirui Ma, Chunwen Zheng, Yuling Niu, Duanrong Cao, Yijun Hu, Ling Jin
Frontiers in Endocrinology.2026;[Epub] CrossRef
Prevalence and associated factors of diabetic kidney disease among rural patients with type 2 diabetes mellitus in Guangxi, China: a cross-sectional study
Yelan Huang, Jingfeng Chen, Chaoqun Bai, Xiaoxue Lei, Yanping Zhang, Guifen Fu
Frontiers in Clinical Diabetes and Healthcare.2026;[Epub] CrossRef
Traditional Chinese medicine in the treatment of diabetic kidney disease: the mechanisms of signaling pathways regulations
Wencan Li, Chaoqi Lei, Qinxuan Wu, Keqian Chen, Zheng Liu, Qichang Xing, Xiang Liu, Jiani Zhang
Frontiers in Endocrinology.2026;[Epub] CrossRef
Lactylation: a metabolic-epigenetic bridge in diabetic kidney disease and a therapeutic target for TCM
Wen Zhang, Xiangdong Zhu, Yan Zhang, Jiahao Yang, Xiaobo Sun, Jianfeng Wang, Bin Zhang
Chinese Medicine.2026;[Epub] CrossRef
Deubiquitinase USP10 regulates angiotensin II-induced renal fibrosis by modulating the expression of TLR4
Rong Wang, Yanjun Shen, Jiaqi Shi, Huaxing Huang, Sujuan Feng, Xingxing Fang, Xiameng Gu, Yang Yu
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis.2026; 832: 111932. CrossRef
Assessing the association of FIB-4 index with diabetic kidney disease in patients with diabetes mellitus: a cross-sectional and retrospective study utilizing NHANES and clinical data
Ronglu Yang, Yongjun Liu, Jinhu Li
Frontiers in Endocrinology.2026;[Epub] CrossRef
Diabetes-related renal complications: Insights on the impact of diabetic kidney disease on mortality
Guido Gembillo, Maria Federica Ricca, Domenico Santoro
World Journal of Nephrology.2026;[Epub] CrossRef
Exosomes in diabetic kidney disease: pathogenesis, biomarker discovery, and emerging therapeutics—a comprehensive systematic review
Lin Ding, Zuolin Li, Yan Xia, Shan Liu, Mingxia Zhang, Lunzhi Liu
Renal Failure.2026;[Epub] CrossRef
Phytochemical characterization and antidiabetic efficacy of elephant foot yam (Amorphophallus paeoniifolius) extract in a high-fat diet and low-dose streptozotocin-induced diabetic rat model
Gopika Biju, Nagaraja Ingaladal, Sruthi P. K., Achuthan C. Ragavamenon, Ravi S. Lankalapalli, M. V. Reshma
Journal of Food Measurement and Characterization.2026; 20(5): 7496. CrossRef
Prediction of Diagnostic Markers and Potential Therapeutic Small-Molecule Drugs for Diabetic Nephropathy
一玮夏
Hans Journal of Biomedicine.2026; 16(02): 323. CrossRef
The diagnostic value of immune-inflammatory markers for diabetic kidney disease in type 2 diabetic patients: a meta-analysis
Yan Wang, Xiaohua Liu, Zhenwen Xiao
Frontiers in Endocrinology.2026;[Epub] CrossRef
Palmitoylation in Renal Physiology and Pathology
Jingru Ma, Zhen Zhang, Jiaqi Guo, Hu Cai, Jian Yao, Dahai Yang, Huiyuan Zhu, Haijing Liu, Changhe Wang, Hongbo Xu
Biomolecules.2026; 16(3): 473. CrossRef
High inflammatory burden may link non-albuminuric diabetic kidney disease to carotid atherosclerosis
Maurizio Di Marco, Sabrina Scilletta, Nicoletta Miano, Nicola Marrano, Annalisa Natalicchio, Angelo Cignarelli, Valentina Annamaria Genchi, Francesco Giorgino, Giosiana Bosco, Francesco Di Giacomo Barbagallo, Roberto Scicali, Francesco Galeano, Andrea Tum
Cardiovascular Diabetology.2026;[Epub] CrossRef
Paeoniflorin‐6′‐O‐Benzenesulfonate Mediates Dendritic Cell Differentiation to Alleviate Diabetic Kidney Disease
Wei Liang, Dongchun Zhu, Lei Xiao, Xiaoqian Wu, Hongwei Zhang, Li Cao, Mengxue Hu, Chun Wang, Feng Xiao, Wei Wei, Tingting Liu
Clinical and Experimental Pharmacology and Physiology.2026;[Epub] CrossRef
Risk Stratification of Chronic Kidney Disease in Adults Using Noninvasive Fibrosis Tests Based on the American Diabetes Association Algorithm
Chan‐Young Jung, Hye Won Lee, Jung Il Lee, Han Ah Lee, Seung Up Kim
Diabetes, Obesity and Metabolism.2026; 28(6): 5240. CrossRef
Succinylation modification in diabetes and diabetic complications: Mechanisms and functions (Review)
Yeteng Xiong, Fei Luo, Bingnan Li, Qinfeng Yang
Molecular Medicine Reports.2026; 33(5): 1. CrossRef
Serum biomarkers in diabetic kidney disease: A comprehensive narrative review
Guido Gembillo, Luca Soraci, Giuseppe Spadaro, Rossella Messina, Felicia Cuzzola, Michela Calderone, Maria Federica Ricca, Simona Di Piazza, Flavia Sudano, Maria Elsa Gambuzza, Maria Princiotto, Lorenzo Lo Cicero, Domenico Santoro
World Journal of Diabetes.2026;[Epub] CrossRef
Correlation of CRP/HDL-C ratio with diabetic kidney disease in type 2 diabetes mellitus patients: evidence from the NHANES 2015–2020
Tingting Wu, Tianwei Gu, Qian Wang, Yuanqin Li, Xuetao Chen, Shanmei Shen, Yangyang Xia
Journal of Laboratory Medicine.2026; 50(3): 153. CrossRef
Clinical Utility of Urinary Cystatin C in Early Screening and Staging of Diabetic Kidney Disease in Type 2 Diabetes
Shanshan Ji, Fanghao Shang, Bingbing Chen, Wentao Tang, Hua Fang, Jinbao Huang, Yizhong Hu, Suraiya Saleem
International Journal of Endocrinology.2026;[Epub] CrossRef
Superior In Vivo Efficacy of Fermented Over Aqueous Astragalus membranaceus in Diabetic Nephropathy: A Systematic Pharmacological Evaluation and Mechanistic Study
Rui Wu, Guangzhe Yao, Huizhen Zhao, Shufeng Zhang, Chao Li, Guangyuan Li, Guoming Wang
Biomedical Chromatography.2026;[Epub] CrossRef
Glycolytic lactylation modulates cell death decisions in diabetic kidney disease: Metabolic‑epigenetic interplay between ferroptosis and autophagy in fibrotic remodeling (Review)
Taimin Zhang, Xizhe Zhang, Yaru Xie, Yue Liu, Siyu Xia, Xiaodie Yin, Tian Li, Libin Liao
International Journal of Molecular Medicine.2026; 57(6): 1. CrossRef
Nephroprotective role of edaravone against polystyrene nanoplastic-induced endoplasmic reticulum stress in Wistar rats
Rachna Yadav, Ashok Jangra, Dinesh Dhingra, Sapana Kushwaha, Itishree Dubey, Dinesh Kumar
Toxicology Mechanisms and Methods.2026; 36(7): 1130. CrossRef
sEH inhibition attenuates mtROS-mediated NLRP3 inflammasome activation by promoting mitophagy in tubular epithelial cells in diabetic kidney disease
Xushun Jiang, Wenge Huang, Wen Wen, Ting Liu, Wei Ren, Jia Shi, Junling He, Xiaogang Du
Frontiers in Immunology.2026;[Epub] CrossRef
Apocynum venetum L. leaves extract inhibits ferroptosis and improves renal fibrosis in diabetic kidney disease by regulating the Nrf2/HO-1 pathway
Guohua Shi, Subinuer Abuduaini, Li Chen, Subinuer Erreken, Mei Long, Xiaoqian Tang, Jinsen Kang
Frontiers in Pharmacology.2026;[Epub] CrossRef
A stabilized enrichment method for rosemary diterpenoids and their therapeutic potential in diabetic kidney disease
Jiali Wei, Qian Xiao, Hua Yang, Fei Li, Ping Li
Chinese Medicine.2026;[Epub] CrossRef
Comment on “Predictive value of the C-reactive protein-albumin-lymphocyte (CALLY) index for all-cause mortality in peritoneal dialysis patients”
Wendi Huang, Yuebo Shi, Yuanyi Yang
International Urology and Nephrology.2026;[Epub] CrossRef
FOS drives podocyte injury and renal fibrosis in diabetic kidney disease via direct Smad3 binding
Man Sun, Tianchi Yan, Wenjing Zhao, Zhifeng Cheng
Cellular and Molecular Life Sciences.2026;[Epub] CrossRef
TangShenKang decoction plays an anti-inflammatory and anti-fibrotic role in diabetic nephropathy by activating AT2R/ATIP1/SHP1 axis and antagonizing angiotensin II
Ran Wei, Jian Ma, Zeyu Yu, Wei Zou, Na Zhao
Molecular and Cellular Biochemistry.2026; 481(6): 2691. CrossRef
Urinary exosomes in diabetic kidney disease: Pathophysiological insights and diagnostic potential
V. Haripriya, Urmila Anandh, Amit Kumar Dinda, Bhargab Kalita
Life Sciences.2026; 399: 124477. CrossRef
Regulatory Effects and Mechanisms of Electromagnetic Low-Energy Shock Wave Therapy on Blood Glucose in Type 2 Diabetic Rats
Yinghui He, Shuying Huo, Linyao Hao, Zipeng Yue, Ying Jiang, Jianhua Zhu, Zhidong Zhou
Biology.2026; 15(10): 810. CrossRef
Bufalin post-transcriptionally suppresses STAT3 to alleviate renal ferroptosis and tubulointerstitial fibrosis in diabetic kidney disease
Yunyang Qiao, Chen Gao, Jialing Ji, Zuolin Li, Huimin Shi, Ruilian Yan, Jiayue Sun, Yueyi Wang, Qiang Lin, Aiqing Zhang
Renal Failure.2026;[Epub] CrossRef
Metabolic Memory-Mediated Epigenetic Regulation of EMT in Diabetic Kidney Disease: Mechanisms and Therapeutic Implications
Xinning Ran, Yidan Xu, Ruonan Liang, Yuqi Duan, Wanying Jia, Yuhong Bian, Chenduo Li, Mingxing Zhang
International Journal of Molecular Sciences.2026; 27(11): 4801. CrossRef
Identification of diagnostic markers for diabetic kidney disease by weighted gene co‑expression network analysis and machine learning
Qiming Xu, Chunjing Xu, Ziyang Liu, Jianrao Lu, Jing Hu, Lin Liao
International Journal of Molecular Medicine.2026; 58(1): 1. CrossRef
Comparative efficacy of lipid-lowering therapies on the cardio-renal-metabolic axis in diabetic kidney disease: a Bayesian network meta-analysis addressing residual CRM risk
Jun Luo, Yinzhong Dai, Chenguang Wu, Chengying Lan, Junwei Shi, Jinfeng Qi, Shimei Hua, Yan An, Lifan Wang, Ping Li, Peng Liu
Frontiers in Endocrinology.2026;[Epub] CrossRef
A plasma N-acetyl amino acid panel for type 2 diabetes discrimination built by targeted LC–MS/MS: A case–control study
Shusi Ding, Zhanxiong Xie, Daqiu Chen, Xiaomai Huang, Qiutong Wu, Lemin Zheng, Shanghua Xu, Shunxiang Luo
Frontiers in Medicine.2026;[Epub] CrossRef
Cardiorespiratory Fitness and Risk of Microvascular Complications in Patients with Type 2 Diabetes Mellitus
Anning Xu, Haofeng Zhou, Chaofan Wang, Qian He, Ping Wu, Wenjing Wu, Hongjiang Wu, Alice P.S. Kong, Huanyi Cao, Haixia Guan, Yunjiu Cheng
Diabetes & Metabolism Journal.2026;[Epub] CrossRef
Biochemical Markers of Diabetic Kidney Injury: A Pharmacological Perspective on Early Intervention
Dr. Abha Sinha, Dr. B. SENTHIL KUMAR, Dr. Pallavi Kadwe, Dr. Niraj Lodha, Radha M, Dr. Souvik Sur
KIDNEYS.2026; 15(1): 257. CrossRef
Renal Biomarkers as Predictors of Renal Damage in Patients With Type 2 Diabetes
Mohamed Osman Ali, DafaAllah Hassan Billal, GadAllah Modawe, Abdelhakam G. Tamomh, Ahmed Ibn Edriss, Yoel A. Klug
BioMed Research International.2026;[Epub] CrossRef
Sex-specific modulation of gut microbiota by empagliflozin contributes to renoprotection in diabetic kidney disease mice
Jundong He, Jiaxin Liu, Heming Zhang, Yiting Wang
Frontiers in Microbiology.2026;[Epub] CrossRef
Biomarkers for Early Detection of Diabetic Kidney Disease in Pediatric and Adolescent Populations: A Narrative Review
Iran Malekzadeh, Narges Falsafi, Mohammad Nazemi, Hanie Taherkhani, Mahboube Bahroudi, Asim Abbas, Mastaneh Moghtaderi
Health Science Reports.2026;[Epub] CrossRef
NAA10 and BTRC drive CREBRF degradation in endoplasmic reticulum stress and renal tubular injury
Sitian Fang, Jing Ning, Jinjing Huang, Yanxia Chen
Journal of Diabetes Investigation.2026; 17(8): 1268. CrossRef
Silencing of USP22 promotes FGF11 degradation to attenuates renal fibrosis in diabetic kidney disease
Zhigang Wang, Chao Liu, Jing Lv, Jiping Sun, Xiaoyang Yu, Huixian Li
Renal Failure.2026;[Epub] CrossRef
Identifying Diabetic Kidney Disease in Type 2 Diabetes Patients Using Explainable Machine Learning: A Case‐Control Study
Tongtong Qiu, Yi Bai, Hai Zhao, Mengyao Huang, Ping Zhang, Yu Zhang, Ruoyu Wang, Liqin An, Hannah Wesley
Journal of Diabetes Research.2026;[Epub] CrossRef
Key module genes in proximal tubular cells drive microenvironmental chronic inflammation and fibrosis in diabetic kidney disease: A single-cell transcriptomic study
Wenjing Zhou, Zhaogui Chen, Guanghui Ying, Li Liu, Wei Xiao, Jian Liu, Min Xia, Qiao Zhang, Xuelin He
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2026; 1872(7): 168326. CrossRef
Baseline and Longitudinal Metabolic Vulnerability Index and Risk of Incident Chronic Kidney Disease Among Adults With Dysglycemia
Dan Chen, Jinsheng Mai, Ziliang Ye, Yanjun Zhang, Sisi Yang, Xiaoqin Gan, Yu Huang, Yiting Wu, Yiwei Zhang, Xianglian Cai, Xiaolong Liang, Xianhui Qin, Yuanyuan Zhang
Journal of Renal Nutrition.2026; 36(5): 739. CrossRef
From cytokine storm to renal scarring in diabetic kidney disease: Biomarkers, risk stratification, and precision therapeutics
Emmanuel Ifeanyi Obeagu
Precision Medical Sciences.2026;[Epub] CrossRef
The dysregulated unfolded protein response in diabetic kidney disease: mechanisms and crosstalk with cell death pathways
Hao Zhang, Kaixiang Li, Jia Ma, Ling Ma, Muhammad Asad Farooq, Jing E
Frontiers in Pharmacology.2026;[Epub] CrossRef
Hsa-miR-5585-3p regulates the NLRP3 activation and the expression of cytokines through CHUK in a cellular model of diabetic kidney disease
Jing Zeng, Xuexiang Qin, Jielian Wang, Cunyou Xiong, Xiaoyun Feng
BMC Endocrine Disorders.2026;[Epub] CrossRef
Ubiquitination‐Related Diagnostic Biomarkers for Diabetic Nephropathy: Insights From Multiomic Analysis, Drug Docking, and Experimental Validation
Ting Dong, Miao Hu, Haibo Yu, Ling Zhou, Qing Qiao
The FASEB Journal.2026;[Epub] CrossRef
Association between 24-h proteinuria and phenotypic age acceleration in adults with preserved kidney function: a cross-sectional study
Yiqi Su, Fangfang Xiang, Yi Fang, Xiaoqiang Ding, Wuhua Jiang
International Urology and Nephrology.2026;[Epub] CrossRef
Exosomes from diabetic perirenal adipose-derived MSCs promote inflammation and fibrosis in diabetic nephropathy via the miR-331-3p/TSC1/mTORC1 Axis
Yumei Zhao, Hejia Yin, Hong Tan, Yan Zhao, Rou Shi, Ye Xing, Yang Li
International Immunopharmacology.2026; 186: 117107. CrossRef
Thai Probiotic Strains Protect Against Diabetic Kidney Injury in HFD/STZ-induced Type 2 Diabetic Rats via Gut Microbiota Modulation
Chattramat Jaiyim, Jirakit Suppamanta, Sasikarn In-um, Kattika Tongdee, Marut Tangwattanachuleeporn, Anongnard Kasorn, Malai Taweechotipatr
Journal of Applied Pharmaceutical Science.2026; 16(6): 176. CrossRef
Gardenin A Alleviates Diabetic Nephropathy by Modulating Oxidative Stress and Inflammation in Experimental Rats
Juan Ji, Longhai Song, Chong Yang, Yan Gao, Song Li, Qiaoying Wu
Pharmacognosy Magazine.2026;[Epub] CrossRef
Tubular PFKFB3 drives diabetic kidney fibrosis via lactate‑dependent H4K12 lactylation and HIPK2 transactivation
Mingkun Xu, Linhang Fu, Yulong Zhang, Xiuli Guo, Han Wu, Sijing Gao, Fei Xiao, Li Xu
International Journal of Molecular Medicine.2026; 58(3): 1. CrossRef
The translational potential of m6A RNA methylation in DKD: emerging biomarkers for early detection and targeted therapies
Huihui Liu, Jun Luo, Yinzhong Dai, Chenguang Wu, Yan An, Wei Jiang
Frontiers in Medicine.2026;[Epub] CrossRef
Roles of Biomarkers in Chronic Kidney Disease and Related Conditions
Takayasu Ohtake, Shuzo Kobayashi
Journal of Clinical Medicine.2026; 15(15): 5920. CrossRef
Pathology-Anchored Biomarker Research Progress for the Early Diagnosis of Diabetic Kidney Disease: From Pathological Association to Early Validation
Qiu Li, Mei Yang, Yingyu Luo, Nannan Zhang
Biomedicines.2026; 14(7): 1643. CrossRef
Defective autophagy in diabetic nephropathy sensitizes podocytes to hyperuricemia induced injury by amplifying inflammasome activation
Chengyu Cao, Yan Fang, Yingxiao Ding, Anyan Li, Fei Jiang, Li Fang
Clinical and Experimental Nephrology.2026; 30(10): 1415. CrossRef
Prognostic Nutritional Index as a Marker Associated With Disease Severity in Diabetic Kidney Disease: A Real-World North African Experience
Khawla Salhi, Salma Berghazi, Mohammed Amine Essafi, Zineb Elazime, Hayat Aynaou, Houda Salhi
Cureus.2026;[Epub] CrossRef
Integrated UHPLC-MS-based metabolomics and transcriptomic profiling reveal the potential role of Phytolacca latbenia in diabetic kidney disease
Fengpu Xie, Nan Wang, Run Qian, Zhao Hu
Chinese Journal of Analytical Chemistry.2026; 54(8): 100737. CrossRef
Mechanism of FABP4-driven macrophage pyroptosis in promoting renal tubular epithelial-mesenchymal transition of diabetic kidney disease in mice
Wenkai Zhang, Songbo Zhao, Li Huang, Rongrong Deng, Xuezhen Ma, Tingting Xing, Ziyi Li, Yingying Wang, Shujun Shi, Xiaochun Zhou, Jianqin Wang
Biochemical Pharmacology.2026; 253: 118378. CrossRef
Multi‐omics–driven precision medicine
Huibo Li, Zhe Zhao, Yifan Zhang, Yao Ma, Gaofei Hu, Min Zeng, Zhanqun Yang, Zixuan Zhao, Xin Zhou, Wei Hu, Yuxuan Sun, Meng Su, Jun Li, Matthew Whiteman, Wei Fu, Chao Zhong, Lemin Zheng, Long Chen, Hairong Lv, Rongsheng Zhao, Yi Zhun Zhu
iMeta.2026;[Epub] CrossRef
LncRNA RAD51-AS1 Alleviates Oxidative Stress and Inflammation in Diabetic Nephropathy by Adsorbing miR-154-5p
Mengmeng Pu, Yijun Chen, Dewei Ouyang
Kidney and Blood Pressure Research.2026; 51(1): 737. CrossRef
Human biomarker navigator
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan
iMeta.2026;[Epub] CrossRef
Emerging therapies for diabetic kidney disease: beyond SGLT2 inhibitors
Huajing Ni, Simon Piggott, Maria Carolina Festa, Labib Faruque, David Z. I. Cherney
Expert Opinion on Pharmacotherapy.2026; 27(13): 1485. CrossRef
Determinants of biochemical factors and microalbuminuria among type 2 diabetes mellitus patients
Ruqaya M. Hassan, Mawj N. Modher, Shahad M. Hussain, Baneen S. Rasool, Yousif Sh. Raheem, Ahmed Flayyih Hasan
Polski Merkuriusz Lekarski.2026; 54(4): 404. CrossRef
The association between pan-immune-inflammation value and diabetic kidney disease: a combined cross-sectional and prospective cohort study
Jian Jin, Shuwu Wei, Jiale Zhang, Jie Yang, Weishuai Sun, Weiwei Sun, Junping Wei, Juan Miao
BMC Endocrine Disorders.2026;[Epub] CrossRef
Clinical value of probiotics as adjunctive therapy for diabetic nephropathy: a meta-analysis and trial sequential analysis
Xiangning Huang, Xinyu Yang, Yunfeng Yu, Jiawang Huang, Wang Tao, Rong Yu, Xiu Liu
Frontiers in Nutrition.2026;[Epub] CrossRef
Diosmetin Restores Endoplasmic Reticulum Homeostasis to Ameliorate Podocyte Injury in Diabetic Kidney Disease by Targeting DNAJC3
Tianyu Zhang, Na Zhao, Tongjin Liu, Yamei Gao, Zhiyue Di, Yue Gao, Yanan Ji, Shuquan Lv, Qingying Xie, Jian Ma, Huantian Cui
Journal of Diabetes Research.2026;[Epub] CrossRef
Association between the cholesterol-high-density lipoprotein-glucose (CHG) index and albuminuria risk in diabetic patients
Yuren Zhang, Jinting Xu, Yiping Zhang, Yinan Chen, Qiaolan Liu
Frontiers in Endocrinology.2026;[Epub] CrossRef
N6-methyladenosine in inflammatory diseases: Important actors and regulatory targets
Zewen Li, Yongfeng Lao, Rui Yan, Fuhan Li, Xin Guan, Zhilong Dong
Gene.2025; 936: 149125. CrossRef
Proteomics exploration of metformin hydrochloride for diabetic kidney disease treatment via the butanoate metabolism pathway
Jinxuan Chai, Yan Wang, Sifan Guo, Zhibo Wang, Hongwei Chen, Xian Wang, Dandan Xie, Ying Cai, Shiwei Wang, Zhencai Hu, Aihua Zhang, Shi Qiu
Journal of Pharmaceutical and Biomedical Analysis.2025; 254: 116584. CrossRef
Global research hotspots and trends in oxidative stress-related diabetic nephropathy: a bibliometric study
Xiao-rong Wang, Zeng Wu, Tong-tong He, Xiao-han Chen, Xiao-fei Jin, Chun-yue Zuo, Shao-ze Yang, Yu Gao, Xiao-hong Zhou, Wei-juan Gao
Frontiers in Endocrinology.2025;[Epub] CrossRef
Implementing novel complete blood count-derived inflammatory indices in the diabetic kidney diseases diagnostic models
Ali Hassanzadeh, Mehdi Allahdadi, Sepehr Nayebirad, Nazli Namazi, Ensieh Nasli-Esfahani
Journal of Diabetes & Metabolic Disorders.2025;[Epub] CrossRef
NR4A1 silencing alleviates high-glucose-stimulated HK-2 cells pyroptosis and fibrosis via hindering NLRP3 activation and PI3K/AKT pathway
Jin-Meng Li, Zi-Hua Song, Yuan Li, Han-Wen Chen, Han Li, Lu Yuan, Jing Li, Wen-Yue Lv, Lei Liu, Na Wang
World Journal of Diabetes.2025;[Epub] CrossRef
Association between drinking patterns and diabetic kidney disease in United States adults: a cross-sectional study based on data from NHANES 1999–2016
Xusheng Yang
Renal Failure.2025;[Epub] CrossRef
Mechanisms, Biomarkers, and Treatment Approaches for Diabetic Kidney Disease: Current Insights and Future Perspectives
Jean Paule Joumaa, Angela Raffoul, Charbel Sarkis, Elizabeth Chatrieh, Sally Zaidan, Philippe Attieh, Frederic Harb, Sami Azar, Hilda E. Ghadieh
Journal of Clinical Medicine.2025; 14(3): 727. CrossRef
Investigation of the role and mechanism of dapagliflozin in mitigating renal injury in rats afflicted with diabetic kidney disease
Hao Wang, Xiuli Zhao, Xiao Wang, Yi Gong, Songping Li, Yanting Gu, Bosai He, Jiahong Wang
Biochemical Pharmacology.2025; 233: 116795. CrossRef
Progress in the application of novel inflammatory indicators in chronic kidney disease
Wenrui Gao, Xiangyu Wang, Yulin Zou, Sheng Wang, Jun Dou, Senlin Qian
Frontiers in Medicine.2025;[Epub] CrossRef
Serum advanced glycation end products as a putative biomarker in Type2 DKD patients’ prognosis
Ze-Hou Wang, Zong-Jin Zhang, Yue-Fen Wang, Jin Xie, Yi-Min Li, Cun Shen, Yuan Meng, Wen-Jing Zhao, Lu-Ying Sun, Wei Jing Liu
Frontiers in Physiology.2025;[Epub] CrossRef
The Potential of Blood KIM‐1 as a Biomarker in Early Diagnosis of Diabetic Kidney Disease
Ningjie Gong, Qian Wang, Zhaoqing Cong, Lezhi Xu, Wenqian Yang, Yang Du
iLABMED.2025; 3(1): 29. CrossRef
Detection of Fast Decliner of Diabetic Kidney Disease Using Chiral Amino Acid Profiling: A Pilot Study
Yosuke Hirakawa, Tomonori Kimura, Shinsuke Sakai, Masayuki Mizui, Masashi Mita, Yoshitaka Isaka, Masaomi Nangaku, Reiko Inagi
Chemistry & Biodiversity.2025;[Epub] CrossRef
Biomarkers: New Advances in Diabetic Nephropathy
Yujia Chen, Xinan Liu, Meniga Shengbu, Qian Shi, Suolang Jiaqiu, Xianrong Lai
Natural Product Communications.2025;[Epub] CrossRef
Uncovering the mechanism of Huangkui capsule in the treatment of diabetic kidney disease based on network pharmacology and experimental validation
Junhong Liu, Ziwei Li, ZongYao Zhang, Zhongyuan Shen
Scientific Reports.2025;[Epub] CrossRef
Melatonin attenuates kidney injury by alleviating lysosomal damage in diabetic kidney disease
Jiaqi Chen, Shuting Zhang, Xiaoquan Xue, Xiaoqin Ma, Aomiao Chen, Yichuan Wu, Geningyue Wang, Qian Zhang, Yaoming Xue, Yijie Jia, Zongji Zheng
Acta Biochimica et Biophysica Sinica.2025; 57(10): 1589. CrossRef
Association of normal range of urinary albumin‐to‐creatinine ratio with all‐cause mortality among diabetic adults with preserved kidney function: National Health and Nutrition Examination Survey (NHANES) 2003–2018
Xiaoxia Pang, Wenchao Dan, Lan Lin, Huimei Li, Xiangrong Rao, Shen Li
Diabetes, Obesity and Metabolism.2025; 27(5): 2670. CrossRef
Oxidative protein destruction products as markers of chronic kidney disease progression in diabetes mellitus
MV Osikov, LA Efros, LYu Zhuravleva, AA Fedosov
Bulletin of Russian State Medical University.2025;[Epub] CrossRef
Research Progress of Factors Influencing Bleeding of Percutaneous Nephrolithotomy
丽梅王
Advances in Clinical Medicine.2025; 15(03): 1580. CrossRef
Serum metabolic profiling of patients with diabetic kidney disease based on gas chromatography-mass spectrometry
Xueyan Bian, Chenwen Wang, Majie Wang, Ailing Yin, Jiayan Xu, Mijia Liu, Hui Wang, Yating Cao, Xin Huang, Chenxue Qin, Ye Zhang, Heming Yu
Frontiers in Molecular Biosciences.2025;[Epub] CrossRef
A Machine Learning-Based Prediction Model for Diabetic Kidney Disease in Korean Patients with Type 2 Diabetes Mellitus
Kyung Ae Lee, Jong Seung Kim, Yu Ji Kim, In Sun Goak, Heung Yong Jin, Seungyong Park, Hyejin Kang, Tae Sun Park
Journal of Clinical Medicine.2025; 14(6): 2065. CrossRef
Association of the stress hyperglycemia ratio for all-cause and cardiovascular mortality in population with cardiovascular-kidney-metabolic syndrome stages 0–4: evidence from a large cohort study
Fan-Shun Guo, Jia-Hao Dou, Jun-Xiang Wang, Chen Guo, Rui-Yun Wu, Xue-Lu Sun, Yi-Wei Hu, Jin Wei
Diabetology & Metabolic Syndrome.2025;[Epub] CrossRef
Progress and perspectives of metabolic biomarkers in blood sample for diabetic microvascular complications
Li Yan, Xu Wang, Yujie Xiang, Shuyi Ru, Cheng Fang, Xiuhong Wu
Metabolomics.2025;[Epub] CrossRef
Predicting diabetic kidney disease with serum metabolomics and gut microbiota
Yuyun Hu, Xue Ni, Qinghuo Chen, Yihui Qu, Kanan Chen, Gaohui Zhu, Minqiao Zhang, Ningjie Xu, Xu Bai, Jing Wang, Yanhong Ma, Qun Luo, Kedan Cai
Scientific Reports.2025;[Epub] CrossRef
Loureirin B analogs mitigate oxidative stress and confer renal protection
Haowen Fang, Xiaodong Sun, Yanting Ding, Bing Niu, Qin Chen
Cellular Signalling.2025; 132: 111787. CrossRef
Circulating Neutrophil and Monocyte Ratios to High Density Lipoprotein-Cholesterol Are Elevated with Increased Triglyceride-Glucose Index
Ishwarlal Jialal, Beverley Adams-Huet
International Journal of Clinical and Translational Medicine.2025; : 5. CrossRef
Cardiovascular Risk Reduction in Patients with Type 2 Diabetes: What Does the Cardiologist Need to Know?
Martin Berger, Nikolaus Marx, Katharina Marx-Schütt
European Cardiology Review.2025;[Epub] CrossRef
Contemporary Perspectives on Chronic Renal Disorders
Deenadhayalan Ashok, Poornima Ajay Manjrekar, Bhushan C. Shetty, Sujina S. S, Rukmini Mysore Srikantiah, Sowndarya Kollampare
Chronic Diseases and Translational Medicine.2025; 11(2): 89. CrossRef
Baseline comorbidity of cardiovascular-kidney-metabolic syndrome increases the risk of adverse clinical outcomes in patients with chronic kidney disease
Jiali Meng, Wen Li, Wenjing Fu, Aihua Zhang
Frontiers in Endocrinology.2025;[Epub] CrossRef
Yangonin Attenuates Streptozotocin-induced Diabetic Nephropathy in Rats via Downregulating Oxidative Stress and Inflammatory Responses
Zhenzhen Hao, Lin Li, Youlan Gong, Yang Xu
Pharmacognosy Magazine.2025; 21(4): 1562. CrossRef
The association between the cardiac metabolic index and rapid kidney function decline and CKD in individuals with different glucose metabolism statuses: results from the China health and retirement longitudinal study
Wei-Zhen Tang, Qin-Yu Cai, Tai-Hang Liu, Tao-Ting Li, Gao-hui Zhu, Jia-cheng Li, Kang-Jin Huang, Hong-Yu Xu, He-Zhe Hua, Rong Li
Lipids in Health and Disease.2025;[Epub] CrossRef
Systemic immune indicators for predicting renal damage in newly diagnosed type 1 diabetic children
Lan-Fang Cao, Qing-Bo Xu, Li Yang
World Journal of Diabetes.2025;[Epub] CrossRef
Shenzhuo formulation ameliorates diabetic nephropathy by regulating cytochrome P450-mediated arachidonic acid metabolism
Zhong-Yong Zhang, Yu-Ming Wang, Ning Wang, Yuan-Song Wang, Hui Zhang, Duo Wang, Li-Xin Wang, Huan-Tian Cui, Wei-Bo Wen, Shu-Quan Lv, Yong-Jun Cao
World Journal of Diabetes.2025;[Epub] CrossRef
An update on renal tubular injury as related to glycolipid metabolism in diabetic kidney disease
Anqi Feng, Ruili Yin, Rong Xu, Baoyu Zhang, Longyan Yang
Frontiers in Pharmacology.2025;[Epub] CrossRef
Revealing VCAN as a Potential Common Diagnostic Biomarker of Renal Tubules and Glomerulus in Diabetic Kidney Disease Based on Machine Learning, Single-Cell Transcriptome Analysis and Mendelian Randomization
Li Jiang, Jie Jian, Xulin Sai, Xiai Wu
Diabetes & Metabolism Journal.2025; 49(3): 407. CrossRef
Dynamic DNA methylation of EPHX2 in diabetic kidney disease progression: A potential biomarker
Guoxiong Deng, Ziyi Feng, Xiaomu Kong, Peng Gao, Yongwei Jiang, Yi Liu, Meimei Zhao, LiangMa
Gene Reports.2025; 40: 102245. CrossRef
Histone deacetylases and their inhibitors in kidney diseases
Yue Zheng, Tie-Ning Zhang, Peng-Hui Hao, Ni Yang, Yue Du
Molecular Therapy.2025; 33(8): 3485. CrossRef
Spinach Extract Reduces Kidney Damage in Diabetic Rats by Impairing the AGEs/RAGE Axis
Javier Flores-Estrada, Agustina Cano-Martínez, Luz Ibarra-Lara, Adriana Jiménez, Carmen Palacios-Reyes, Luis J. Pinto García, María G. Ortiz-López, Olga Nelly Rodríguez-Peña, Luis Barbo Hernández-Portilla
International Journal of Molecular Sciences.2025; 26(10): 4730. CrossRef
KIM-1 como biomarcador de lesão tubular renal em pacientes com diabetes mellitus tipo 2 normoalbuminúricos e com resistência à insulina
Laura Eduarda de Oliveira, Clóvis Paniz, Rafael Noal Moresco, José Antonio Mainardi de Carvalho
Brazilian Journal of Nephrology.2025;[Epub] CrossRef
KIM-1 as a biomarker of kidney tubular damage in normoalbuminuric patients with type 2 diabetes mellitus and insulin resistance
Laura Eduarda de Oliveira, Clóvis Paniz, Rafael Noal Moresco, José Antonio Mainardi de Carvalho
Brazilian Journal of Nephrology.2025;[Epub] CrossRef
Role of Physical Activity in Reducing Diabetic Kidney Disease Risk in Adults: Data From the National Health and Nutrition Examination Survey, 2017–2018
Wirampa Tanglai, Apichai Wattanapisit, Osamu Watanabe, Thanakrit Jeamjitvibool, Mark Lockwood, Mia Cajita
Diabetes/Metabolism Research and Reviews.2025;[Epub] CrossRef
Genetics of diabetes and its complications: a comprehensive review
Abdul Sami, Ahsan Javed, Dilber Uzun Ozsahin, Ilker Ozsahin, Khalid Muhammad, Yasir Waheed
Diabetology & Metabolic Syndrome.2025;[Epub] CrossRef
Serum metabolic profiling in diabetic kidney disease patients using ultra-high performance liquid chromatography-tandem mass spectrometry
Bin Zhang, Chunmei Dai, Jiuyi Jiang, Jun Wang, Yuwei Yang, Jiafu Feng
Diabetology & Metabolic Syndrome.2025;[Epub] CrossRef
Urine Biomarkers for Diabetic Kidney Disease Progression in Participants of the Chronic Renal Insufficiency Cohort Study
Sarah J. Schrauben, Xiaoming Zhang, Dawei Xie, Steven Coca, Jason H. Greenberg, Joachim H. Ix, Michael G. Shlipak, Chi-yuan Hsu, Jonathan J. Taliercio, Chirag R. Parikh, Orlando Gutierrez, Mark J. Sarnak, Mirela A. Dobre, Debbie Cohen, Jeffrey R. Schellin
Clinical Journal of the American Society of Nephrology.2025; 20(7): 958. CrossRef
Melatonin Protects Against Diabetic Kidney Disease via the SIRT1/NLRP3 Signalling Pathway
Yaping Zhang, Yinghui Wang, Jingyan Yang, Gang Liu
Nephrology.2025;[Epub] CrossRef
Apelin Alleviated Endothelial‐To‐Mesenchymal Transition via Increasing BKCa in Diabetic Nephropathy
Chunmeng Fan, Yu Liu, Jing Chang, Mingcong Huang, Zihao Gao, Huade Wang, Xiang Zheng, Menghe Li, Jialiang Xu, Jiming Yin, Xiangjun Zeng
The FASEB Journal.2025;[Epub] CrossRef
Association Between DNA Methylation of MTHFR and Diabetic Kidney Disease
Guoxiong Deng, Ziyi Feng, Xiaomu Kong, Peng Gao, Yongwei Jiang, Yi Liu, Meimei Zhao, Liang Ma, Kalyani Sen
Journal of Diabetes Research.2025;[Epub] CrossRef
PHGDH alleviates DKD by regulating YB1/SLC7A11-mediated ferroptosis in podocytes
Yinghui Wang, Qingqing Zhang, Shasha Lv, Xueling Wang, Qingzhen Liu, Xiangchun Liu, Yaping Zhang, Gang Liu
Translational Research.2025; 282: 1. CrossRef
Comparative effectiveness of traditional Chinese medicine injections combined with ACEI/ARB for diabetic nephropathy: A systematic review and network meta-analysis
Aijing Li, Maoying Wei, Chan Wu, Dan Yin, Yiting Tang, Yijia Jiang, Churan Wang, Jingyi Guo, Anning Sun, Xin Gu, Yanbing Gong
Frontiers in Pharmacology.2025;[Epub] CrossRef
Fecal microbiota transplantation is a promising therapy for kidney diseases
Jiawei Zhang, Xiangge Ren, Bing Li, Zhifen Zhao, Shoudao Li, Wensheng Zhai
Frontiers in Medicine.2025;[Epub] CrossRef
Kaempferol improves mitochondrial homeostasis via mitochondrial dynamics and mitophagy in diabetic kidney disease
Chenhui Xia, Jiale Zhang, Huixi Chen, Weimin Jiang, Shaofeng Zhou, Huijuan Zheng, Weiwei Sun
International Immunopharmacology.2025; 162: 115121. CrossRef
Polygonati Rhizoma Polysaccharides Ameliorated Diabetic Kidney Disease in db/db Mice via Inhibiting TGFβ/Smad2 Signaling Pathway
Xiyu Mei, Zeming Ren, Ziyun Gao, Sisi Chen, Xuan Chen, Qingyun Zhou, Yeling Tong, Guanhai Dai
Food Science & Nutrition.2025;[Epub] CrossRef
Therapeutic Potential of Cinnamic Acid as an SGLT2 Inhibitor in Mitigating Diabetic Nephropathy in a Rat Model of Type 2 Diabetes
Setah Naif Alotaibi, Ghedeir M. Alshammari, Nawal A. Albadr, Mohammed Abdo Yahya
Molecular Nutrition & Food Research.2025;[Epub] CrossRef
Asprosin Levels in Adults with Type 2 Diabetes Mellitus and Diabetic Kidney Disease: A Systematic Review and Meta-Analysis
Jovana Ristic, Sena Kodalak, Gonzalo Peralta-Jiménez, Maria Moura de Lima, Marijana Kovacevic, Srdjan Masic, Tatjana Nikolic
Diabetes, Metabolic Syndrome and Obesity.2025; Volume 18: 2493. CrossRef
Notch signaling in diabetic kidney disease: recent progress
Zhi-Hui Wang, Wei Tu, Ya-Ni Long, Peng-Fei Li, Kai-Ying He, Jing Wu
Frontiers in Endocrinology.2025;[Epub] CrossRef
Sirtuin 3 in diabetic kidney disease: mechanisms and pharmacotherapy
Yinfeng Chen, Ying Wang, Dongrong Yu, Hailing Zhao, Ping Li
Renal Failure.2025;[Epub] CrossRef
Mechanism of Rhizoma Chuanxiong for the treatment of diabetic kidney disease based on network pharmacology
Yuhe Yan, Honghong Shi, Yue Li, Xing Wan, Jinxin Li, Lihua Wang
Renal Failure.2025;[Epub] CrossRef
The potential adding therapeutic effect of pentoxifylline and/or folic acid for chronic kidney disease patients: randomized controlled trial
Amira Reda Muhammad Galal, Nahla Mohamed Teama, Karema Abu–Elfotuha, Ahmed D. Alatawi, Hanan Alshareef, Ahmed M. E. Hamdan, Ahmed Aljabri, Mohannad Alshibani, Zeinab AlKasaby Mahmoud Zalat
BMC Nephrology.2025;[Epub] CrossRef
Association between a diabetes-predictive index and diabetes-related kidney disease in U.S. adults: A cross-sectional study
Haonan Wu, Zheng Nan
Preventive Medicine Reports.2025; 58: 103225. CrossRef
Asprosin Aggravates Tubular Epithelial Cell Injury and Phenotypic Transformation via Mitochondrial Dynamics Disorder Mediated by Excessive Drp1 SUMOylation in Diabetic Nephropathy Mice
Qianqian Huang, Xiaowei Xiong, Sheng Chen, Yuan Wang, Li Wang, Wentao Liu, Chen Liu, Guohua Zeng, Qiren Huang
Advanced Science.2025;[Epub] CrossRef
C3AR1 may aggravate diabetic nephropathy by mediating oxidative stress via ITGB2 regulation in renal tubular epithelial cells
Alex Abura, Shan Gao, Shinsuke Yuasa
PLOS One.2025; 20(9): e0331900. CrossRef
Exploration of the renoprotective effect of Yi-Shen-Hua-Shi granules on db/db mice and the mechanism of podocyte apoptosis based on the GRP78/CHOP signaling pathway
Yanmo Cai, Yunhua Liu, Sitong Wang, Ge Jin, Kaidong Zhou, Xin Zhou, Xinxue Zhang, Min Zhang, Zongjiang Zhao
Frontiers in Pharmacology.2025;[Epub] CrossRef
Protective effects of Shenkang injection against diabetic kidney disease via p38 MAPK/NFκB/MCP-1/CCR2 pathway inhibition
Xin Zhou, Sitong Wang, Ge Jin, Kaidong Zhou, Yanmo Cai, Zongjiang Zhao
Frontiers in Endocrinology.2025;[Epub] CrossRef
Prevalence of diabetes and prediabetes among working-age adults and influencing factors of new-onset diabetes: a five-year cohort study (2018–2023)
Jing Tan, Mingzhu Chen, Yang Lei, Xiaofen Shi, Cuiping Cao, Naili Du, Yuyou Yao, Xiaojuan Yao
Frontiers in Endocrinology.2025;[Epub] CrossRef
Celastrol, a bioactive compound from Tripterygium wilfordii, exerts renoprotective effects by modulating the gut-kidney axis and PPAR signaling in a mouse model of diabetic kidney disease
Yue-Wen Tang, Jia-Wei Cao, Meng-Dan Lu, Ru-Chun Yang, Feng Wan
Asian Pacific Journal of Tropical Biomedicine.2025; 15(9): 353. CrossRef
Expression Profile of Urinary Exosomal miRNAs in Patients With Diabetic Kidney Disease and Their Association With Kidney Damage
Juan Li, Lulu Han, Ting Wang, Lin Yang, Hong Zhou, Pawel Grzmil
International Journal of Endocrinology.2025;[Epub] CrossRef
Commentary on: Inhibition of LINC00707/miR‐223‐3p/FKBP5 axis has a protective effect on diabetic kidney disease
Yirui Zhao, Fengyue Zhang
Journal of Diabetes Investigation.2025; 16(12): 2251. CrossRef
Research on Glycemic Variability Characteristics in Diabetic Patients Undergoing Hemodialysis
俊杰苏
Journal of Clinical Personalized Medicine.2025; 04(05): 100. CrossRef
Short-Term: Cellular Metabolism and Gene Expression During the Onset of Diabetic Kidney Disease: A Diabetes Mellitus Experimental Model
Jéssica Encinas, Glaucia Veiga, Joyce Raimundo, Matheus Perez, Giuliana Petri, Renan Cavalheiro, Pedro Reis, Laura Maifrino, Beatriz Alves, Fernando Fonseca
International Journal of Molecular Sciences.2025; 26(19): 9676. CrossRef
Construction of a diagnostic model and identification of effect genes for diabetic kidney disease with concurrent vascular calcification based on bioinformatics and multiple machine learning approaches
Lili Huang, Wenjing Wu, Shenhui Lv, Danfang Deng, Xiaoqin Wang
Frontiers in Molecular Biosciences.2025;[Epub] CrossRef
Selected miRNAs in Urinary Extracellular Vesicles Show Promise for Early and Specific Diagnostics of Diabetic Kidney Disease
Karina Barreiro, Jenni Karttunen, Erkka Valo, Essi Viippola, Ileana Quintero, Annemari Käräjämäki, Antti Rannikko, Harry Holthöfer, Andrea Ganna, Niina Sandholm, Lena M. Thorn, Per‐Henrik Groop, Tiinamaija Tuomi, Om Prakash Dwivedi, Maija Puhka
Journal of Extracellular Biology.2025;[Epub] CrossRef
Multi-omics and machine learning identify FN1 and ALDH2 as diagnostic biomarkers and therapeutic targets in early and late diabetic kidney disease
Jingwei Lin, Yingying Zheng, Diman Mai, Fuxiang Fang, Zhuokun Wei, Mengyu Liu, Trung Hieu Pham, Ming Li, Jiawen Zhao
Renal Failure.2025;[Epub] CrossRef
Yiqi Wenyang Formula ameliorates diabetic kidney disease via inhibiting inflammation and regulating the gut microbiota-bile acid axis in mice by FXR signaling pathway
Tongyi Yuan, Xiang Gao, Xinxin Wang, Xiaolei Tang, Zuguo Liang, Yifei Yin, Songyan Liu, Jianze Ou, Wenjie Su, Zepeng Zhang, Xiangyan Li, Qingxia Huang, Daqing Zhao, He Zhang
Chinese Medicine.2025;[Epub] CrossRef
Qing-Re-Xiao-Zheng-yi-qi formula protects renal function by stabilizing lysosomal membranes and inhibiting NLRP3-inflammasome-mediated pyroptosis in diabetic kidney disease
Lei Tian, Lin Wang, Yutong Wang, Weijing Liu, Wenjing Zhao, Yaoxian Wang
Annals of Medicine.2025;[Epub] CrossRef
The Inflammatory Cell Death in Diabetic Kidney Disease: Integrating Multifactorial Mechanisms into Novel Therapeutics
Bin Fang, Wei Huang, Sijia Du, Yu Hao, Fangfang He, Chun Zhang
International Journal of Molecular Sciences.2025; 26(22): 11033. CrossRef
Rhein Inhibits Podocyte Ferroptosis and Epithelial-Mesenchymal Transition in Diabetic Nephropathy by Activating the SIRT1/p53/SLC7A11 Pathway
Wei Hu, Dan Xiong
BIOCELL.2025; 49(9): 1711. CrossRef
Diagnostic Roles of circXPNPEP3 as Biomarker for Diabetic Nephropathy
Miao Liu, Qiunan Zhan, Junjun Zhu, Junli Zhao, Danyan Min
Diabetes, Metabolic Syndrome and Obesity.2025; Volume 18: 4287. CrossRef
Protective Effects of Hydrogen Treatment Against High Glucose-Induced Oxidative Stress and Apoptosis via Inhibition of the AGEs/RAGE/NF-κB Signaling Pathway in Skin Cells
Pan Yu, Nan Hong, Qiong Wu, Zhipeng Zhao
Endocrine, Metabolic & Immune Disorders - Drug Targets.2025;[Epub] CrossRef
The Clinical Significance of Serum Sirtuin 2 in Diabetic Nephropathy: Evidence for a Potential Biomarker of Renal Injury
Ozgur Yilmaz, Osman Erinc, Murvet Algemi, Recep Demirci, Sengul Aydin Yoldemir, Murat Akarsu
Journal of Clinical Medicine.2025; 14(22): 8095. CrossRef
The “Picasso faces” of diabetic kidney disease – how the art of phenotyping and molecular biomarkers is transforming clinical nephrology: an observational study in patients with type 2 diabetes
Małgorzata Rodzoń-Norwicz, Natalia Potocka, Marzena Skrzypa, Izabela Zawlik, Katarzyna Milian–Ciesielska, Patryk Kogut, Krzysztof Gargasz, Michael Maes, Magdalena Sowa-Kućma, Agnieszka Gala-Błądzińska
BMC Nephrology.2025;[Epub] CrossRef
The Association of Lipoic Acid Synthase (LIAS) Gene Methylation With Diabetic Kidney Disease
Ziyi Feng, Ting Liu, Peng Gao, Yongwei Jiang, Meimei Zhao, Yi Liu, Haoyan Zhu, Mo Li, Nan Li, Xiaomu Kong, Liang Ma, Zhipeng Tao
Journal of Diabetes Research.2025;[Epub] CrossRef
Association between triglyceride–glucose index and its derivatives and lung adenocarcinoma risk: a case–control study in Chinese adults
Pengcheng Qiu, Jinshi Xie, Yayuan He, Rizheng Cong, Keyue Huang, Bo Huang
Frontiers in Endocrinology.2025;[Epub] CrossRef
Klotho in diabetes mellitus: research progress and clinical implications
Tingyuan Zhu, Songfeng Zhao, Ning Lu
Frontiers in Endocrinology.2025;[Epub] CrossRef
The mediating role of inflammation in the association between coagulation parameters and diabetic kidney diseases in patients with type 2 diabetes mellitus: a muti-center cross-sectional retrospective study in Southwest China from 2013 to 2022
Bei-Hui Ren, Ling-Zhi Xing, Bai-Yu-Lu Chen, Guo-Jia Liao, Li-Yuan Chen, Ying-Dan Zhang, Jie Fan, Ling Chen
BMC Nephrology.2025;[Epub] CrossRef
Syndecan-1 as a Prognostic Biomarker for Early Diabetic Kidney Disease Progression: A Cohort Study
Yiqun Peng, Dongguang Wang, Kaifa Guo, Liang Peng
Journal of Medicine and Physical Education.2025; 2(5): 40. CrossRef
Role of polyphenols in the management of diabetic complications
Jeevika Raina, Atika Firdous, Gurvinder Singh, Rajesh Kumar, Charanjit Kaur
Phytomedicine.2024; 122: 155155. CrossRef
Single-Cell RNA Sequencing Reveals RAC1 Involvement in Macrophages Efferocytosis in Diabetic Kidney Disease
Yi Song, Yifan Liu, Feng Guo, Lin Zhao, Guijun Qin
Inflammation.2024; 47(2): 753. CrossRef
Role of MCP-1 as an inflammatory biomarker in nephropathy
Yanlong Liu, Ke Xu, Yuhua Xiang, Boyan Ma, Hailong Li, Yuan Li, Yue Shi, Shuju Li, Yan Bai
Frontiers in Immunology.2024;[Epub] CrossRef
Urinary podocyte stress marker as a prognostic indicator for diabetic kidney disease
Lingfeng Zeng, Jack Kit-Chung Ng, Winston Wing-Shing Fung, Gordon Chun-Kau Chan, Kai-Ming Chow, Cheuk-Chun Szeto
BMC Nephrology.2024;[Epub] CrossRef
Identification and validation of immune and cuproptosis - related genes for diabetic nephropathy by WGCNA and machine learning
Yubing Chen, Lijuan Liao, Baoju Wang, Zhan Wu
Frontiers in Immunology.2024;[Epub] CrossRef
Specific Alternation of Gut Microbiota and the Role of Ruminococcus gnavus in the Development of Diabetic Nephropathy
Jinni Hong, Tingting Fu, Weizhen Liu, Yu Du, Junmin Bu, Guojian Wei, Miao Yu, Yanshan Lin, Cunyun Min, Datao Lin
Journal of Microbiology and Biotechnology.2024; 34(3): 547. CrossRef
The triglyceride-glucose index is superior to homeostasis model assessment of insulin resistance in predicting metabolic syndrome in an adult population in the United States
Beverley Adams-Huet, Rafael Zubirán, Alan T. Remaley, Ishwarlal Jialal
Journal of Clinical Lipidology.2024; 18(4): e518. CrossRef
Association of the dietary inflammatory index with complicated diabetic kidney disease in people with diabetes mellitus: evidence from NHANES 2009–2018
Yixin Rui, Xiumeng Zhang, Hongxiao Xie, Hu Qi, Rong Liu, Nan Zeng
Acta Diabetologica.2024; 61(11): 1375. CrossRef
Multiomics Analyses Identify AKR1A1 as a Biomarker for Diabetic Kidney Disease
DengFeng Li, Fang-Chi Hsu, Nicholette D. Palmer, Liang Liu, Young A. Choi, Mariana Murea, John S. Parks, Donald W. Bowden, Barry I. Freedman, Lijun Ma
Diabetes.2024; 73(7): 1188. CrossRef
Serum L C3-II levels in type 2 diabetic patients with impaired renal functions
Shahab Ahmed Salıh Gezh, Koksal Deveci, Hakan Sivgin, Figen Guzelgul
Cytokine.2024; 181: 156683. CrossRef
Diabetic Nephropathy as a Result of Uncontrolled Hyperglycemia
Camila Silva de Aquino, Estênio Gabriel Miranda, Francisco José Pascoal Ribeiro Júnior, Hérika Juliana de Araújo Lucena, Jéssica Pará Amaral de Oliveira, João Ferreira Lima Neto, Lênio Airam de Pinho, Miguel Valentim Rodrigues, Pedro Henrique Borges Silve
Revista de Gestão Social e Ambiental.2024; 18(1): e07716. CrossRef
Pharmacological effects of bioactive agents in earthworm extract: A comprehensive review
Zihan Zhu, Xinyi Deng, Wenqing Xie, Hengzhen Li, Yusheng Li, Zhenhan Deng
Animal Models and Experimental Medicine.2024; 7(5): 653. CrossRef
Efficacy and safety of polyethylene glycol loxenatide in treating mild-to-moderate diabetic kidney disease in type 2 diabetes patients: a randomized, open-label, clinical trial
YongSheng Cao, Shujie Cao, Jiangang Zhao, Jianqin Zhao, Yanan Zhao, Ying Liu
Frontiers in Endocrinology.2024;[Epub] CrossRef
Fish oil supplementation in relation to the risk of chronic kidney disease among patients with diabetes
Yang Ao, Hao Ye, Xiaohui Liu, Yin Li, Haoyin Liu, Shu Ye, Yepeng Hu, Pan Zhuang, Yu Zhang, Chao Zheng, Jingjing Jiao
Diabetes, Obesity and Metabolism.2024; 26(11): 5283. CrossRef
CYSTATIN C—A Monitoring Perspective of Chronic Kidney Disease in Patients with Diabetes
Alexandra-Mihaela Visinescu, Emilia Rusu, Andrada Cosoreanu, Gabriela Radulian
International Journal of Molecular Sciences.2024; 25(15): 8135. CrossRef
Role of proadrenomedullin in the progression of diabetic kidney disease in patients with type 2 diabetes mellitus
A.M. Urbanovych, A.P. Vereshchynska
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine).2024; 20(4): 266. CrossRef
Sirt6 overexpression relieves ferroptosis and delays the progression of diabetic nephropathy via Nrf2/GPX4 pathway
Lingyu Du, Canghui Guo, Shengnan Zeng, Ke Yu, Maodong Liu, Ying Li
Renal Failure.2024;[Epub] CrossRef
Single-cell RNA sequencing in diabetic kidney disease: a literature review
Wei Tan, Jiaoyan Chen, Yunyan Wang, Kui Xiang, Xianqiong Lu, Qiuyu Han, Mingyue Hou, Jurong Yang
Renal Failure.2024;[Epub] CrossRef
Podocyte Death in Diabetic Kidney Disease: Potential Molecular Mechanisms and Therapeutic Targets
Suye Zhong, Na Wang, Chun Zhang
International Journal of Molecular Sciences.2024; 25(16): 9035. CrossRef
Serum biomarkers for predicting microvascular complications of diabetes mellitus
Jiajia Wang, Xiaoyi Song, Ziqiao Xia, Shu Feng, Hangfeng Zhang, Chengjie Xu, Hui Zhang
Expert Review of Molecular Diagnostics.2024; 24(8): 703. CrossRef
Association of Serum Tsukushi Levels with Urinary Albumin-Creatinine Ratio in Type 2 Diabetes Patients
Yanyan Li, Xia Deng, Xunan Wu, Ligang Zhou, Guoyue Yuan
Diabetes, Metabolic Syndrome and Obesity.2024; Volume 17: 3295. CrossRef
Liraglutide ameliorates inflammation and fibrosis by downregulating the TLR4/MyD88/NF-κB pathway in diabetic kidney disease
Linjing Huang, Tingting Lin, Meizhen Shi, Peiwen Wu
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology.2024; 327(4): R410. CrossRef
Molecular Therapeutics for Diabetic Kidney Disease: An Update
Man Guo, Fangfang He, Chun Zhang
International Journal of Molecular Sciences.2024; 25(18): 10051. CrossRef
Angiopoietin‐like 4 is a potential biomarker for diabetic kidney disease in type 2 diabetes patients
Yan Wang, Kun Li, Shasha Yuan, Caiguo Yu, Ruili Yin, Di Wang, Yongsong Xu, Lijie Zhang, Lingling Wei, Yanan Cheng, Lin Mao, Dong Zhao, Longyan Yang
Journal of Diabetes Investigation.2024; 15(12): 1763. CrossRef
Integrating network pharmacology and experimental validation to decipher the pharmacological mechanism of DXXK in treating diabetic kidney injury
Chenxu Zhang, Zhangxin Ji, Na Xu, Jingjing Yuan, Wen Zeng, Yadong Wang, Qing He, Jiaxing Dong, Xinyu Zhang, Dongmei Yang, Wei Jiang, Yibo Yan, Wencui Shang, Jun Chu, Quangen Chu
Scientific Reports.2024;[Epub] CrossRef
Proteome-wide mendelian randomization identifies novel therapeutic targets for chronic kidney disease
Pin Zhao, Zhenhao Li, Shilong Xue, Jinshan Cui, Yonghao Zhan, Zhaowei Zhu, Xuepei Zhang
Scientific Reports.2024;[Epub] CrossRef
Update on the Pathogenesis, Diagnosis, and Treatment of Diabetic Tubulopathy
Danfeng Liu, Xiaojie Chen, Weiting He, Min Lu, Qiuling Li, Shaogui Zhang, Jianteng Xie, Yifan Zhang, Wenjian Wang
Integrative Medicine in Nephrology and Andrology.2024;[Epub] CrossRef
Identification of circulating microbial DNA and its association with kidney function in patients with diabetic kidney disease
Hoang Thuy Linh, Megumi Oshima, Keisuke Sako, Masahiro Konishi, Daiki Hayashi, Hajime Sanada, Takahiro Yuasa, Akihiko Koshino, Keisuke Horikoshi, Taichiro Minami, Shunsuke Tsuge, Akira Tamai, Shiori Nakagawa, Ryo Nishioka, Takeshi Zoshima, Kiyoaki Ito, Ic
Nephrology.2024; 29(12): 909. CrossRef
Association of Succinate and Adenosine Nucleotide Metabolic Pathways with Diabetic Kidney Disease in Patients with Type 2 Diabetes Mellitus
Inha Jung, Seungyoon Nam, Da Young Lee, So Young Park, Ji Hee Yu, Ji A Seo, Dae Ho Lee, Nan Hee Kim
Diabetes & Metabolism Journal.2024; 48(6): 1126. CrossRef
Role of Epigenetic Changes in the Pathophysiology of Diabetic Kidney Disease
Marita Liebisch, Gunter Wolf
Glomerular Diseases.2024; 4(1): 211. CrossRef
Characteristics and Risk of Incident Diabetic Nephropathy between Early-onset versus Late-onset Type 2 Diabetics of Nigerian Origin
Collins Amadi, Johnbosco Chidozie Okafor, Ochuko Otokunefor, Ezra Agbo
European Journal of Medical and Health Sciences.2024; 6(6): 60. CrossRef
Research progress of gut microbiome and diabetic nephropathy
Chenling Chu, Tapas Ranjan Behera, Ying Huang, Wenhui Qiu, Jiayi Chen, Quanquan Shen
Frontiers in Medicine.2024;[Epub] CrossRef
Targeting programmed cell death in diabetic kidney disease: from molecular mechanisms to pharmacotherapy
Fengzhao Liu, Zhenyu Yang, Jixin Li, Tao Wu, Xiangyu Li, Lijuan Zhao, Wenru Wang, Wenfei Yu, Guangheng Zhang, Yunsheng Xu
Molecular Medicine.2024;[Epub] CrossRef
Dynamic changes of inflammatory markers in the early stages of chronic kidney disease in patients with type 1 diabetes mellitus
MV Osikov, LA Efros, LYu Zhuravleva, AA Fedosov
Bulletin of Russian State Medical University.2024;[Epub] CrossRef
A Narrative Review of New Treatment Options for Diabetic Nephropathy
Aadhira Pillai, Darshna Fulmali
Cureus.2023;[Epub] CrossRef
Bamboo leaf: A review of traditional medicinal property, phytochemistry, pharmacology, and purification technology
Yaqian Cheng, Siqi Wan, Linna Yao, Ding Lin, Tong Wu, Yongjian Chen, Ailian Zhang, Chenfei Lu
Journal of Ethnopharmacology.2023; 306: 116166. CrossRef
Molecular Pathways of Diabetic Kidney Disease Inferred from Proteomics
Lan Wei, Yuanyuan Han, Chao Tu
Diabetes, Metabolic Syndrome and Obesity.2023; Volume 16: 117. CrossRef
Omics and Artificial Intelligence in Kidney Diseases
Nadja Grobe, Josef Scheiber, Hanjie Zhang, Christian Garbe, Xiaoling Wang
Advances in Kidney Disease and Health.2023; 30(1): 47. CrossRef
Intestinal microbiome diversity of diabetic and non-diabetic kidney disease: Current status and future perspective
Soumik Das, Ramanathan Gnanasambandan
Life Sciences.2023; 316: 121414. CrossRef
Pediatric Diabetic Nephropathy: Novel Insights from microRNAs
Francesca Lanzaro, Annalisa Barlabà, Angelica De Nigris, Federica Di Domenico, Valentina Verde, Emanuele Miraglia del Giudice, Anna Di Sessa
Journal of Clinical Medicine.2023; 12(4): 1447. CrossRef
Novel Biomarkers of Diabetic Kidney Disease
Jorge Rico-Fontalvo, Gustavo Aroca-Martínez, Rodrigo Daza-Arnedo, José Cabrales, Tomás Rodríguez-Yanez, María Cardona-Blanco, Juan Montejo-Hernández, Dairo Rodelo Barrios, Jhonny Patiño-Patiño, Elber Osorio Rodríguez
Biomolecules.2023; 13(4): 633. CrossRef
Diabetic vascular diseases: molecular mechanisms and therapeutic strategies
Yiwen Li, Yanfei Liu, Shiwei Liu, Mengqi Gao, Wenting Wang, Keji Chen, Luqi Huang, Yue Liu
Signal Transduction and Targeted Therapy.2023;[Epub] CrossRef
Metabolic phenotypes and risk of end-stage kidney disease in patients with type 2 diabetes
Lijun Zhao, Yutong Zou, Yucheng Wu, Linli Cai, Yuancheng Zhao, Yiting Wang, Xiang Xiao, Qing Yang, Jia Yang, Honghong Ren, Nanwei Tong, Fang Liu
Frontiers in Endocrinology.2023;[Epub] CrossRef
Identification of a New RNA and Protein Integrated Biomarker Panel Associated with Kidney Function Impairment in DKD: Translational Implications
Alessandra Scamporrino, Stefania Di Mauro, Agnese Filippello, Grazia Di Marco, Antonino Di Pino, Roberto Scicali, Maurizio Di Marco, Emanuele Martorana, Roberta Malaguarnera, Francesco Purrello, Salvatore Piro
International Journal of Molecular Sciences.2023; 24(11): 9412. CrossRef
Increased serum PCSK9 levels are associated with renal function impairment in patients with type 2 diabetes mellitus
Zhicai Feng, Xiangyu Liao, Hao Zhang, Juan Peng, Zhijun Huang, Bin Yi
Renal Failure.2023;[Epub] CrossRef
Analysis of Serum Pyrodeath Re-lated Proteins and Renal Injury in Patients with Type 2 DKD
茹洁马
Asian Case Reports in Emergency Medicine.2023; 11(02): 53. CrossRef
Loganin reduces diabetic kidney injury by inhibiting the activation of NLRP3 inflammasome-mediated pyroptosis
Xiangri Kong, Yunyun Zhao, Xingye Wang, Yongjiang Yu, Ying Meng, Guanchi Yan, Miao Yu, Lihong Jiang, Wu Song, Bingmei Wang, Xiuge Wang
Chemico-Biological Interactions.2023; 382: 110640. CrossRef
Machine-learning algorithm-based prediction of a diagnostic model based on oxidative stress-related genes involved in immune infiltration in diabetic nephropathy patients
Heng-Mei Zhu, Na Liu, Dong-Xuan Sun, Liang Luo
Frontiers in Immunology.2023;[Epub] CrossRef
The roles of gut microbiota and its metabolites in diabetic nephropathy
Hui Zhao, Cheng-E Yang, Tian Liu, Ming-Xia Zhang, Yan Niu, Ming Wang, Jun Yu
Frontiers in Microbiology.2023;[Epub] CrossRef
High triglyceride levels increase the risk of diabetic microvascular complications: a cross-sectional study
Jiahang Li, Lei Shi, Guohong Zhao, Fei Sun, Zhenxing Nie, Zhongli Ge, Bin Gao, Yan Yang
Lipids in Health and Disease.2023;[Epub] CrossRef
Correlation of Kidney Injury Molecule-1 and Nephrin Levels in Iraqi Patients with Diabetic Nephropathy
Raghda Hisham Aljorani, Eman Saadi Saleh , Khalaf Gata Hussein Al Mohammadawi
Al-Rafidain Journal of Medical Sciences ( ISSN 2789-3219 ).2023; 5: 99. CrossRef
Diabetic Nephropathy: Significance of Determining Oxidative Stress and Opportunities for Antioxidant Therapies
Marina Darenskaya, Sergey Kolesnikov, Natalya Semenova, Lyubov Kolesnikova
International Journal of Molecular Sciences.2023; 24(15): 12378. CrossRef
Evaluation of Neutrophil/Lymphocyte Ratio, Low-Density Lipoprotein/Albumin Ratio, and Red Cell Distribution Width/Albumin Ratio in the Estimation of Proteinuria in Uncontrolled Diabetic Patients
Duygu Tutan, Murat Doğan
Cureus.2023;[Epub] CrossRef
Hedysarum polybotrys polysaccharide attenuates renal inflammatory infiltration and fibrosis in diabetic mice by inhibiting the HMGB1/RAGE/TLR4 pathway
Changqing Xu, Yanxu Cheng, Zongmei Liu, Xiaoyan Fu
Experimental and Therapeutic Medicine.2023;[Epub] CrossRef
Abdominal adipose tissue and type 2 diabetic kidney disease: adipose radiology assessment, impact, and mechanisms
Fei Lu, Jinlei Fan, Fangxuan Li, Lijing Liu, Zhiyu Chen, Ziyu Tian, Liping Zuo, Dexin Yu
Abdominal Radiology.2023; 49(2): 560. CrossRef
Inhibition of MD2 by natural product-drived JM-9 attenuates renal inflammation and diabetic nephropathy in mice
Minxiu Wang, Qianhui Zhang, Shuaijie Lou, Leiming Jin, Gaojun Wu, Wenqi Wu, Qidong Tang, Yi Wang, Xiaohong Long, Ping Huang, Wu Luo, Guang Liang
Biomedicine & Pharmacotherapy.2023; 168: 115660. CrossRef
Multifaceted relationship between diabetes and kidney diseases: Beyond diabetes
Pasquale Esposito, Daniela Picciotto, Francesca Cappadona, Francesca Costigliolo, Elisa Russo, Lucia Macciò, Francesca Viazzi
World Journal of Diabetes.2023; 14(10): 1450. CrossRef
Mitochondrial antiviral signaling protein: a potential therapeutic target in renal disease
Meng Wu, Zhiyin Pei, Guangfeng Long, Hongbing Chen, Zhanjun Jia, Weiwei Xia
Frontiers in Immunology.2023;[Epub] CrossRef
Research progress on multiple cell death pathways of podocytes in diabetic kidney disease
Can Yang, Zhen Zhang, Jieting Liu, Peijian Chen, Jialing Li, Haiying Shu, Yanhui Chu, Luxin Li
Molecular Medicine.2023;[Epub] CrossRef
Quantitative profiling of carboxylic compounds by gas chromatography-mass spectrometry for revealing biomarkers of diabetic kidney disease
Rongrong Zhu, Yan Yuan, Rourou Qi, Jianying Liang, Yan Shi, Hongbo Weng
Journal of Chromatography B.2023; 1231: 123930. CrossRef
Jiangtang Decoction Ameliorates Diabetic Kidney Disease Through the Modulation of the Gut Microbiota
Jinni Hong, Tingting Fu, Weizhen Liu, Yu Du, Junmin Bu, Guojian Wei, Miao Yu, Yanshan Lin, Cunyun Min, Datao Lin
Diabetes, Metabolic Syndrome and Obesity.2023; Volume 16: 3707. CrossRef
GLP-1RA Combined with SGLT2 Inhibitors for the Treatment of Diabetic Kidney Disease: A Meta Analysis
莹郭
Advances in Clinical Medicine.2023; 13(11): 18117. CrossRef
Potential application of Klotho as a prognostic biomarker for patients with diabetic kidney disease: a meta-analysis of clinical studies
Li Xia Yu, Min Yue Sha, Yue Chen, Fang Tan, Xi Liu, Shasha Li, Qi-Feng Liu
Therapeutic Advances in Chronic Disease.2023;[Epub] CrossRef
Research progress of natural active compounds on improving podocyte function to reduce proteinuria in diabetic kidney disease
Le Gong, Rui Wang, Xinyu Wang, Jing Liu, Zhaodi Han, Qian Li, Yi Jin, Hui Liao
Renal Failure.2023;[Epub] CrossRef
Identification of potential crosstalk genes and mechanisms between periodontitis and diabetic nephropathy through bioinformatic analysis
Huijuan Lu, Jia Sun, Jieqiong Sun
Medicine.2023; 102(52): e36802. CrossRef
Identifying Biomarkers for Diabetic Kidney Disease Using GraphSAGE Neural Network
Sesugh Gabriel Abenga, Kehinde Seyi Olalekan, Francis Akogwu Alu, Stephen Yavenga Uyoo
Journal of Computer and Communications.2023; 11(10): 51. CrossRef
Mitochondrial RNAs as Potential Biomarkers of Functional Impairment in Diabetic Kidney Disease
Stefania Di Mauro, Alessandra Scamporrino, Agnese Filippello, Maurizio Di Marco, Maria Teresa Di Martino, Francesca Scionti, Antonino Di Pino, Roberto Scicali, Roberta Malaguarnera, Francesco Purrello, Salvatore Piro
International Journal of Molecular Sciences.2022; 23(15): 8198. CrossRef
Renoprotective Mechanism of Sodium-Glucose Cotransporter 2 Inhibitors: Focusing on Renal Hemodynamics
Nam Hoon Kim, Nan Hee Kim
Diabetes & Metabolism Journal.2022; 46(4): 543. CrossRef
Partial Synthetic PPARƳ Derivative Ameliorates Aorta Injury in Experimental Diabetic Rats Mediated by Activation of miR-126-5p Pi3k/AKT/PDK 1/mTOR Expression
Yasmin M. Ahmed, Raha Orfali, Nada S. Abdelwahab, Hossam M. Hassan, Mostafa E. Rateb, Asmaa M. AboulMagd
Pharmaceuticals.2022; 15(10): 1175. CrossRef
Polydatin attenuates tubulointerstitial fibrosis in diabetic kidney disease by inhibiting YAP expression and nuclear translocation
Manlin He, Lan Feng, Yang Chen, Bin Gao, Yiwei Du, Lu Zhou, Fei Li, Hongbao Liu
Frontiers in Physiology.2022;[Epub] CrossRef
Prevalence of diabetic nephropathy in the diabetes mellitus population: A protocol for systematic review and meta-analysis
Sicheng Li, Huidi Xie, Yang Shi, Hongfang Liu
Medicine.2022; 101(42): e31232. CrossRef
Stratification of diabetic kidney diseases via data-independent acquisition proteomics–based analysis of human kidney tissue specimens
Qinghua Huang, Xianming Fei, Zhaoxian Zhong, Jieru Zhou, Jianguang Gong, Yuan Chen, Yiwen Li, Xiaohong Wu
Frontiers in Endocrinology.2022;[Epub] CrossRef
Novel biomarkers and therapeutic approaches for diabetic retinopathy and nephropathy: Recent progress and future perspectives
Ziyan Xie, Xinhua Xiao
Frontiers in Endocrinology.2022;[Epub] CrossRef
Diabetic Kidney Disease
Susanne B. Nicholas, Amy K. Mottl
Nephrology Self-Assessment Program.2022; 21(5): 394. CrossRef

Original Article

Metabolic Risk/Epidemiology
Plasma Targeted Metabolomics Analysis for Amino Acids and Acylcarnitines in Patients with Prediabetes, Type 2 Diabetes Mellitus, and Diabetic Vascular Complications: Xin Li, Yancheng Li, Yuanhao Liang, Ruixue Hu, Wenli Xu, Yufeng Liu; Diabetes Metab J. 2021;45(2):195-208. Published online March 9, 2021; DOI: https://doi.org/10.4093/dmj.2019.0209

13,010 View
257 Download
32 Web of Science
30 Crossref

Graphical Abstract Abstract PDF Supplementary Material PubReader ePub

Background
We hypothesized that specific amino acids or acylcarnitines would have benefits for the differential diagnosis of diabetes. Thus, a targeted metabolomics for amino acids and acylcarnitines in patients with diabetes and its complications was carried out.
Methods
A cohort of 54 normal individuals and 156 patients with type 2 diabetes mellitus and/or diabetic complications enrolled from the First Affiliated Hospital of Jinzhou Medical University was studied. The subjects were divided into five main groups: normal individuals, impaired fasting glucose, overt diabetes, diabetic microvascular complications, and diabetic peripheral vascular disease. The technique of tandem mass spectrometry was applied to obtain the plasma metabolite profiles. Metabolomics multivariate statistics were applied for the metabolic data analysis and the differential metabolites determination.
Results
A total of 10 cross-comparisons within diabetes and its complications were designed to explore the differential metabolites. The results demonstrated that eight comparisons existed and yielded significant metabolic differences. A total number of 24 differential metabolites were determined from six selected comparisons, including up-regulated amino acids, down-regulated medium-chain and long-chain acylcarnitines. Altered differential metabolites provided six panels of biomarkers, which were helpful in distinguishing diabetic patients.
Conclusion
Our results demonstrated that the biomarker panels consisted of specific amino acids and acylcarnitines which could reflect the metabolic variations among the different stages of diabetes and might be useful for the differential diagnosis of prediabetes, overt diabetes and diabetic complications.

Citations

Citations to this article as recorded by

Targeted amino acid profiling reveals early metabolic alterations in young-onset type 2 diabetes mellitus
Bhanu Prasad Palivela, Vijayasarathy Ketavarapu, Divya Presingu, Keerthi Reddy, Ramunaidu Addipilli, Mitnala Sasikala, Jagadeshwar Reddy Thota
Clinica Chimica Acta.2027; 594: 121311. CrossRef
Integrated network pharmacology and multi-omics reveals GLUD1-mediated α-KG/Glu conversion in regulating amino acid metabolism: a mechanism of Dangua Fang against type 2 diabetes mellitus
Zhuang Han, Liuqing Yang, Zhita Wang, Liang Li, Linxi Jin, Qiwei Chen, Shuhong Yao, Xinmiao Hong, Caizuan Zhang, Jinyong Xu, Hua Huang, Guoli Shang, Yuwei Lin, Ting Song, Xianpei Heng
Journal of Ethnopharmacology.2026; 360: 121198. CrossRef
Metabolomics in type 2 diabetes: From pathogenesis to biomarkers, precision treatment, and complication management
Hongli Zhou, Yuanyuan Li, Yu Tian, Qingqing Zhang, Qian Dai, Yue Zhang, Zhili Rao, Jianyun Zhou
Gene.2026; 990: 150055. CrossRef
The Genetic Landscape of Diabetes Mellitus: Lessons from Monogenic and Polygenic Forms
Davide Nilo, Roberto Nilo, Marta Chiara Sircana, Ferdinando Carlo Sasso, Carlo Acierno, Leonilde Bonfrate, Alfredo Caturano
Life.2026; 16(3): 399. CrossRef
Association of circulating branched-chain or aromatic amino acids based on metabolome and apolipoprotein E genotype with incident dementia: a large cohort study
Ziwei Liu, Yongjun Ai, Yue Wu, Yuncheng Zhang, Jianian Hua, Tong Liu, Dong Liu, Guo-Chong Chen, Guangfei Xu, Li-Hua Chen
International Journal of Food Sciences and Nutrition.2026; 77(3): 248. CrossRef
Integrative genomic and metabolomic analyses identify novel associations between mQTLs and common diseases in Han Chinese
Jiaying Cai, Jiahao Zhang, Yating Fu, Meng Zhu, Chen Zhu, Chen Ji, Chen Jin, Huimin Ma, Mingxuan Zhu, Caochen Zhang, Lili Wu, Lingbin Du, Hongxia Ma
Journal of Biomedical Research.2026; 40: 1. CrossRef
Plasma metabolomics reveals progressive alterations across glycemic states
Yun-Tong Liu, Li-Ping Yu, Dong-Li Zhu, Zhen-Ping Li, Jin-Ping Zhang, Ling-Ding Xie, Lu-Lu Song, Yi-Fan He, Xian Jin, Zhao-Qing Li, Rui-Fen Deng, Cong Zhang, Bo Zhang
World Journal of Diabetes.2026;[Epub] CrossRef
Integrated Multi-Tissue Omics Identifies Acylcarnitine Accumulation as Shared Metabolic Marker of Diabetic Microangiopathy With Cross-Organ Validation
Qian Liu, Yan Liu, Xiongyi Yang, Tianyi Liu, Ya Zhao, Jiao Xia, Xueyun Fu, Mudi Yao, Yufan Wang, Qin Jiang, Biao Yan
Investigative Ophthalmology & Visual Science.2026; 67(11): 31. CrossRef
Rapid Determination of Acylcarnitine Metabolic Diseases by Trifluoroacetic Acid-Doped Extraction Coupled with Nanoelectrospray Ionization Mass Spectrometry
Yali Yang, Hong Zhang, Jing He, Yun Ju, Mingyi Wang, Lishun Wu, Jie Jiang
Analytical Chemistry.2025; 97(2): 1395. CrossRef
Multi-omics approaches for biomarker discovery and precision diagnosis of prediabetes
Jielin Song, Chuanfu Wang, Tong Zhao, Yu Zhang, Jixiang Xing, Xuelian Zhao, Yunsha Zhang, Zhaohui Zhang
Frontiers in Endocrinology.2025;[Epub] CrossRef
Metabolism of Polyamine in Vascular Diseases: An Prospective Therapeutic Target
Yuanyu Li, Anying Cheng, Fan He
Bratislava Medical Journal.2025; 126(6): 845. CrossRef
Charged Water Enables the Determination of Inherited Metabolic Diseases by Mass Spectrometry
Yali Yang, Jie Jiang, Jing He, Yun Ju, Yanxiao Jiang, Hong Zhang
Analytical Chemistry.2025; 97(29): 15923. CrossRef
A comprehensive review on computational metabolomics: Advancing multiscale analysis through in-silico approaches
Mohamed S. Nafie, Abdelghafar M. Abu-Elsaoud, Mohamed K. Diab
Computational and Structural Biotechnology Journal.2025; 27: 3191. CrossRef
Differential Network Analysis Integrates Pathway Mapping to Characterize Dynamic Metabolic Changes in the Progression of Diabetic Complications
Wuping Liu, Yao Huang, Chanyi Li, Ge Song, Mengxiang Xiao, Guiping Shen, Jianghua Feng
Journal of Proteome Research.2025; 24(9): 4526. CrossRef
Metabolomics uncovers the diabetes metabolic network: from pathophysiological mechanisms to clinical applications
Zijie Xu, Yujia Zhou, Ruijie Xie, Zhongxing Ning
Frontiers in Endocrinology.2025;[Epub] CrossRef
Association of circulating branched-chain amino acids with risk of pre-diabetes: a systematic review and meta-analysis
Yu Wang, Jiang-Hong Xiao, Xi-Mei Zhang, Wen-Xiao Wang, Qiao Zhang, Yu-Ping Tang, Shi-Jun Yue
PeerJ.2025; 13: e20054. CrossRef
Metabolomics Signature in Prediabetes and Diabetes: Insights From Tandem Mass Spectrometry Analysis
Saad Ayyal Jabbar Al‐Rikabi, Ali Etemadi, Maher Mohammed Morad, Azin Nowrouzi, Ghodratollah Panahi, Mozhgan Mondeali, Mahsa Toorani‐ghazvini, Ensieh Nasli‐Esfahani, Farideh Razi, Fatemeh Bandarian
Endocrinology, Diabetes & Metabolism.2024;[Epub] CrossRef
Liquid Biopsy: A Game Changer for Type 2 Diabetes
Gratiela Gradisteanu Pircalabioru, Madalina Musat, Viviana Elian, Ciprian Iliescu
International Journal of Molecular Sciences.2024; 25(5): 2661. CrossRef
Metabolomics for Clinical Biomarker Discovery and Therapeutic Target Identification
Chunsheng Lin, Qianqian Tian, Sifan Guo, Dandan Xie, Ying Cai, Zhibo Wang, Hang Chu, Shi Qiu, Songqi Tang, Aihua Zhang
Molecules.2024; 29(10): 2198. CrossRef
Identification of FGF13 as a Potential Biomarker and Target for Diagnosis of Impaired Glucose Tolerance
Qi Chen, Fangyu Li, Yuanyuan Gao, Fengying Yang, Li Yuan
International Journal of Molecular Sciences.2023; 24(2): 1807. CrossRef
Quantitative, Targeted Analysis of Gut Microbiota Derived Metabolites Provides Novel Biomarkers of Early Diabetic Kidney Disease in Type 2 Diabetes Mellitus Patients
Lavinia Balint, Carmen Socaciu, Andreea Iulia Socaciu, Adrian Vlad, Florica Gadalean, Flaviu Bob, Oana Milas, Octavian Marius Cretu, Anca Suteanu-Simulescu, Mihaela Glavan, Silvia Ienciu, Maria Mogos, Dragos Catalin Jianu, Ligia Petrica
Biomolecules.2023; 13(7): 1086. CrossRef
Unlocking the Potential: Amino Acids’ Role in Predicting and Exploring Therapeutic Avenues for Type 2 Diabetes Mellitus
Yilan Ding, Shuangyuan Wang, Jieli Lu
Metabolites.2023; 13(9): 1017. CrossRef
Untargeted metabolomics reveals dynamic changes in metabolic profiles of rat supraspinatus tendon at three different time points after diabetes induction
Kuishuai Xu, Liang Zhang, Tianrui Wang, Zhongkai Ren, Tengbo Yu, Yingze Zhang, Xia Zhao
Frontiers in Endocrinology.2023;[Epub] CrossRef
Acylcarnitines: Can They Be Biomarkers of Diabetic Nephropathy?
Xiaodie Mu, Min Yang, Peiyao Ling, Aihua Wu, Hua Zhou, Jingting Jiang
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2022; Volume 15: 247. CrossRef
Targeted metabolomics analysis of amino acids and acylcarnitines as risk markers for diabetes by LC–MS/MS technique
Shaghayegh Hosseinkhani, Babak Arjmand, Arezou Dilmaghani-Marand, Sahar Mohammadi Fateh, Hojat Dehghanbanadaki, Niloufar Najjar, Sepideh Alavi-Moghadam, Robabeh Ghodssi-Ghassemabadi, Ensieh Nasli-Esfahani, Farshad Farzadfar, Bagher Larijani, Farideh Razi
Scientific Reports.2022;[Epub] CrossRef
Identification of Insulin Resistance Biomarkers in Metabolic Syndrome Detected by UHPLC-ESI-QTOF-MS
Leen Oyoun Alsoud, Nelson C. Soares, Hamza M. Al-Hroub, Muath Mousa, Violet Kasabri, Nailya Bulatova, Maysa Suyagh, Karem H. Alzoubi, Waseem El-Huneidi, Bashaer Abu-Irmaileh, Yasser Bustanji, Mohammad H. Semreen
Metabolites.2022; 12(6): 508. CrossRef
Serum Untargeted Metabolomics Reveal Potential Biomarkers of Progression of Diabetic Retinopathy in Asians
Zongyi Wang, Jiyang Tang, Enzhong Jin, Yusheng Zhong, Linqi Zhang, Xinyao Han, Jia Liu, Yong Cheng, Jing Hou, Xuan Shi, Huijun Qi, Tong Qian, Li Yuan, Xianru Hou, Hong Yin, Jianhong Liang, Mingwei Zhao, Lvzhen Huang, Jinfeng Qu
Frontiers in Molecular Biosciences.2022;[Epub] CrossRef
Circulating amino acids and acylcarnitines correlated with different CAC score ranges in diabetic postmenopausal women using LC–MS/MS based metabolomics approach
Shaghayegh Hosseinkhani, Pooneh Salari, Fatemeh Bandarian, Mojgan Asadi, Shapour Shirani, Niloufar Najjar, Hojat Dehghanbanadaki, Parvin Pasalar, Farideh Razi
BMC Endocrine Disorders.2022;[Epub] CrossRef
Metabolomic comparison followed by cross-validation of enzyme-linked immunosorbent assay to reveal potential biomarkers of diabetic retinopathy in Chinese with type 2 diabetes
Zongyi Wang, Jiyang Tang, Enzhong Jin, Chi Ren, Siying Li, Linqi Zhang, Yusheng Zhong, Yu Cao, Jianmin Wang, Wei Zhou, Mingwei Zhao, Lvzhen Huang, Jinfeng Qu
Frontiers in Endocrinology.2022;[Epub] CrossRef
Urine Metabolites Enable Fast Detection of COVID-19 Using Mass Spectrometry
Alexandre Varao Moura, Danilo Cardoso de Oliveira, Alex Ap. R. Silva, Jonas Ribeiro da Rosa, Pedro Henrique Dias Garcia, Pedro Henrique Godoy Sanches, Kyana Y. Garza, Flavio Marcio Macedo Mendes, Mayara Lambert, Junier Marrero Gutierrez, Nicole Marino Gra
Metabolites.2022; 12(11): 1056. CrossRef

First
Prev
Page of 1
Next
Last

Search