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Original Article
Basic Research
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Single-Cell Landscape and a Macrophage Subset Enhancing Brown Adipocyte Function in Diabetes
Junfei Gu, Jiajia Jin, Xiaoyu Ren, Xinjie Zhang, Jiaxuan Li, Xiaowei Wang, Shucui Zhang, Xianlun Yin, Qunye Zhang, Zhe Wang
Diabetes Metab J. 2024;48(5):885-900.   Published online May 29, 2024
DOI: https://doi.org/10.4093/dmj.2023.0278
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AbstractAbstract PDFSupplementary MaterialPubReader   ePub   
Background
Metabolic dysregulation is a hallmark of type 2 diabetes mellitus (T2DM), in which the abnormalities in brown adipose tissue (BAT) play important roles. However, the cellular composition and function of BAT as well as its pathological significance in diabetes remain incompletely understood. Our objective is to delineate the single-cell landscape of BAT-derived stromal vascular fraction (SVF) and their characteristic alterations in T2DM rats.
Methods
T2DM was induced in rats by intraperitoneal injection of low-dose streptozotocin and high-fat diet feeding. Single-cell mRNA sequencing was then performed on BAT samples and compared to normal rats to characterize changes in T2DM rats. Subsequently, the importance of key cell subsets in T2DM was elucidated using various functional studies.
Results
Almost all cell types in the BAT-derived SVF of T2DM rats exhibited enhanced inflammatory responses, increased angiogenesis, and disordered glucose and lipid metabolism. The multidirectional differentiation potential of adipose tissue-derived stem cells was also reduced. Moreover, macrophages played a pivotal role in intercellular crosstalk of BAT-derived SVF. A novel Rarres2+macrophage subset promoted the differentiation and metabolic function of brown adipocytes via adipose-immune crosstalk.
Conclusion
BAT SVF exhibited strong heterogeneity in cellular composition and function and contributed to T2DM as a significant inflammation source, in which a novel macrophage subset was identified that can promote brown adipocyte function.
Review
Basic Research
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Multiple Roles of Sirtuin 6 in Adipose Tissue Inflammation
Eun Ju Bae, Byung-Hyun Park
Diabetes Metab J. 2023;47(2):164-172.   Published online January 12, 2023
DOI: https://doi.org/10.4093/dmj.2022.0270
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  • 4 Web of Science
  • 2 Crossref
AbstractAbstract PDFPubReader   ePub   
Adipose tissue (AT) inflammation is strongly associated with obesity-induced insulin resistance. When subjected to metabolic stress, adipocytes become inflamed and secrete a plethora of cytokines and chemokines, which recruit circulating immune cells to AT. Although sirtuin 6 (Sirt6) is known to control genomic stabilization, aging, and cellular metabolism, it is now understood to also play a pivotal role in the regulation of AT inflammation. Sirt6 protein levels are reduced in the AT of obese humans and animals and increased by weight loss. In this review, we summarize the potential mechanism of AT inflammation caused by impaired action of Sirt6 from the immune cells’ point of view. We first describe the properties and functions of immune cells in obese AT, with an emphasis on discrete macrophage subpopulations which are central to AT inflammation. We then highlight data that links Sirt6 to functional phenotypes of AT inflammation. Importantly, we discuss in detail the effects of Sirt6 deficiency in adipocytes, macrophages, and eosinophils on insulin resistance or AT browning. In our closing perspectives, we discuss emerging issues in this field that require further investigation.

Citations

Citations to this article as recorded by  
  • The Role of Increased Expression of Sirtuin 6 in the Prevention of Premature Aging Pathomechanisms
    Adrianna Dzidek, Olga Czerwińska-Ledwig, Małgorzata Żychowska, Wanda Pilch, Anna Piotrowska
    International Journal of Molecular Sciences.2023; 24(11): 9655.     CrossRef
  • Exploring the Influence of Age, Gender and Body Mass Index on Colorectal Cancer Location
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Original Article
Pathophysiology
Low-Frequency Intermittent Hypoxia Suppresses Subcutaneous Adipogenesis and Induces Macrophage Polarization in Lean Mice
Yan Wang, Mary Yuk Kwan Lee, Judith Choi Wo Mak, Mary Sau Man Ip
Diabetes Metab J. 2019;43(5):659-674.   Published online April 23, 2019
DOI: https://doi.org/10.4093/dmj.2018.0196
  • 5,192 View
  • 53 Download
  • 5 Web of Science
  • 6 Crossref
AbstractAbstract PDFSupplementary MaterialPubReader   
Background

The relationship between obstructive sleep apnoea (OSA) and metabolic disorders is complex and highly associated. The impairment of adipogenic capacity in pre-adipocytes may promote adipocyte hypertrophy and increase the risk of further metabolic dysfunction. We hypothesize that intermittent hypoxia (IH), as a pathophysiologic feature of OSA, may regulate adipogenesis by promoting macrophage polarization.

Methods

Male C57BL/6N mice were exposed to either IH (240 seconds of 10% O2 followed by 120 seconds of 21% O2, i.e., 10 cycles/hour) or intermittent normoxia (IN) for 6 weeks. Stromal-vascular fractions derived from subcutaneous (SUB-SVF) and visceral (VIS-SVF) adipose tissues were cultured and differentiated. Conditioned media from cultured RAW 264.7 macrophages after air (Raw) or IH exposure (Raw-IH) were incubated with SUB-SVF during adipogenic differentiation.

Results

Adipogenic differentiation of SUB-SVF but not VIS-SVF from IH-exposed mice was significantly downregulated in comparison with that derived from IN-exposed mice. IH-exposed mice compared to IN-exposed mice showed induction of hypertrophic adipocytes and increased preferential infiltration of M1 macrophages in subcutaneous adipose tissue (SAT) compared to visceral adipose tissue. Complementary in vitro analysis demonstrated that Raw-IH media significantly enhanced inhibition of adipogenesis of SUB-SVF compared to Raw media, in agreement with corresponding gene expression levels of differentiation-associated markers and adipogenic transcription factors.

Conclusion

Low frequency IH exposure impaired adipogenesis of SAT in lean mice, and macrophage polarization may be a potential mechanism for the impaired adipogenesis.

Citations

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Reviews
Pathophysiology
Role of NO/VASP Signaling Pathway against Obesity-Related Inflammation and Insulin Resistance
Yu Mi Kang, Francis Kim, Woo Je Lee
Diabetes Metab J. 2017;41(2):89-95.   Published online November 15, 2016
DOI: https://doi.org/10.4093/dmj.2017.41.2.89
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  • 22 Web of Science
  • 20 Crossref
AbstractAbstract PDFPubReader   

Obesity has quickly become a worldwide pandemic, causing major adverse health outcomes such as dyslipidemia, type 2 diabetes mellitus, cardiovascular disease and cancers. Obesity-induced insulin resistance is the key for developing these metabolic disorders, and investigation to understand the molecular mechanisms involved has been vibrant for the past few decades. Of these, low-grade chronic inflammation is suggested as a critical concept in the development of obesity-induced insulin resistance, and the anti-inflammatory effect of nitric oxide (NO) signaling has been reported to be linked to improvement of insulin resistance in multiple organs involved in glucose metabolism. Recently, a body of evidence suggested that vasodilatory-stimulated phosphoprotein (VASP), a downstream mediator of NO signaling plays a crucial role in the anti-inflammatory effect and improvement of peripheral insulin resistance. These preclinical studies suggest that NO/VASP signaling could be an ideal therapeutic target in the treatment of obesity-related metabolic dysfunction. In this review, we introduce studies that investigated the protective role of NO/VASP signaling against obesity-related inflammation and insulin resistance in various tissues.

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Resistin in Rodents and Humans
Hyeong Kyu Park, Rexford S. Ahima
Diabetes Metab J. 2013;37(6):404-414.   Published online December 12, 2013
DOI: https://doi.org/10.4093/dmj.2013.37.6.404
  • 6,996 View
  • 74 Download
  • 124 Crossref
AbstractAbstract PDFPubReader   

Obesity is characterized by excess accumulation of lipids in adipose tissue and other organs, and chronic inflammation associated with insulin resistance and an increased risk of type 2 diabetes. Obesity, type 2 diabetes, and cardiovascular diseases are major health concerns. Resistin was first discovered as an adipose-secreted hormone (adipokine) linked to obesity and insulin resistance in rodents. Adipocyte-derived resistin is increased in obese rodents and strongly related to insulin resistance. However, in contrast to rodents, resistin is expressed and secreted from macrophages in humans and is increased in inflammatory conditions. Some studies have also suggested an association between increased resistin levels and insulin resistance, diabetes and cardiovascular disease. Genetic studies have provided additional evidence for a role of resistin in insulin resistance and inflammation. Resistin appears to mediate the pathogenesis of atherosclerosis by promoting endothelial dysfunction, vascular smooth muscle cell proliferation, arterial inflammation, and formation of foam cells. Indeed, resistin is predictive of atherosclerosis and poor clinical outcomes in patients with coronary artery disease and ischemic stroke. There is also growing evidence that elevated resistin is associated with the development of heart failure. This review will focus on the biology of resistin in rodents and humans, and evidence linking resistin with type 2 diabetes, atherosclerosis, and cardiovascular disease.

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  • A Negative Energy Balance Is Associated with Metabolic Dysfunctions in the Hypothalamus of a Humanized Preclinical Model of Alzheimer’s Disease, the 5XFAD Mouse
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  • Resistin in pregnancy: Analysis of determinants in pairs of umbilical cord blood and maternal serum
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    Cytokine: X.2021; 3(2): 100052.     CrossRef
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    Mohammed Taouis, Yacir Benomar
    Molecular and Cellular Endocrinology.2021; 533: 111341.     CrossRef
  • The dynamics of human bone marrow adipose tissue in response to feeding and fasting
    Pouneh K. Fazeli, Miriam A. Bredella, Gisela Pachon-Peña, Wenxiu Zhao, Xun Zhang, Alexander T. Faje, Megi Resulaj, Sai P. Polineni, Tara M. Holmes, Hang Lee, Elizabeth K. O’Donnell, Ormond A. MacDougald, Mark C. Horowitz, Clifford J. Rosen, Anne Klibanski
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  • Resistin: A journey from metabolism to cancer
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  • Human Milk Metabolic Hormones: Analytical Methods and Current Understanding
    Majed A. Suwaydi, Zoya Gridneva, Sharon L. Perrella, Mary E. Wlodek, Ching Tat Lai, Donna T. Geddes
    International Journal of Molecular Sciences.2021; 22(16): 8708.     CrossRef
  • Adipokines as Immune Cell Modulators in Multiple Sclerosis
    Merel Rijnsburger, Niek Djuric, Inge A. Mulder, Helga E. de Vries
    International Journal of Molecular Sciences.2021; 22(19): 10845.     CrossRef
  • The Role of Adipokines in Cardiovascular Pathology
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  • Measurement of Plasma Resistin Concentrations in Horses with Metabolic and Inflammatory Disorders
    Beatriz Fuentes-Romero, Alberto Muñoz-Prieto, José J. Cerón, María Martín-Cuervo, Manuel Iglesias-García, Escolástico Aguilera-Tejero, Elisa Díez-Castro
    Animals.2021; 12(1): 77.     CrossRef
  • EFFECT OF DIET AND EXERCISE-INDUCE WEIGHT LOSS ON LEVEL OF RESISTIN IN PATIENT WITH OBESITY
    О. I. Tokarenko, I. O. Andreieva, O. O. Tokarenko, M. M. Surmilo
    Modern medical technology.2021; (4): 11.     CrossRef
  • Alteration of gut microbiota affects expression of adiponectin and resistin through modifying DNA methylation in high-fat diet-induced obese mice
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  • Resistin hormone in diabetic kidney disease and its relation to iron status and hepcidin
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    International Urology and Nephrology.2020; 52(4): 749.     CrossRef
  • Proteoglycans in Obesity-Associated Metabolic Dysfunction and Meta-Inflammation
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  • Resistin Is Increased in Periodontal Cells and Tissues: In Vitro and In Vivo Studies
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  • The possible role of endocrine dysfunction of adipose tissue in gestational diabetes mellitus
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  • High Plasma Resistin Levels Portend the Insulin Resistance-Associated Susceptibility to Early Cognitive Decline in Patients with Type 2 Diabetes Mellitus
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  • Adipokines: New Potential Therapeutic Target for Obesity and Metabolic, Rheumatic, and Cardiovascular Diseases
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  • Correlation of CCL18 with Levels of Adi-pokines in the Sera of Patients with Myocardial Infarction in a 6-Month Period: Case Series
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  • Association of RETN − 420 C/G Genotypes with CRP, Brain Edema, GCS, and GOS Among Patients with Traumatic Cerebral Hemorrhagic Contusion
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  • Resistin and adenylyl cyclase-associated protein 1 (CAP1) regulate the expression of genes related to insulin resistance in BNL CL.2 mouse liver cells
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  • Proteomic profile of patients with atrial fibrillation undergoing cardiac surgery†
    Ilias P Doulamis, George Samanidis, Aspasia Tzani, Asier Antoranz, Anastasios Gkogkos, Panagiotis Konstantopoulos, Vaia Pliaka, Angeliki Minia, Leonidas G Alexopoulos, Despina N Perrea, Konstantinos Perreas
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  • Early Life Exposures to Perfluoroalkyl Substances in Relation to Adipokine Hormone Levels at Birth and During Childhood
    Colleen Shelly, Philippe Grandjean, Youssef Oulhote, Peter Plomgaard, Ruth Frikke-Schmidt, Flemming Nielsen, Denis Zmirou-Navier, Pal Weihe, Damaskini Valvi
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  • Effects of major adipokines and the −420 C > G resistin gene polymorphism on the long-term outcome of patients with acute ischemic stroke
    Stella Bouziana, Konstantinos Tziomalos, Antonis Goulas, Timoleon-Achilleas Vyzantiadis, Maria Papadopoulou, Athanasia Panderi, Apostolos Ι. Ηatzitolios
    International Journal of Neuroscience.2019; 129(10): 978.     CrossRef
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  • Implications of resistin in type 2 diabetes mellitus and coronary artery disease: Impairing insulin function and inducing pro‐inflammatory cytokines
    Melissa Emamalipour, Khaled Seidi, Ali Jahanban‐Esfahlan, Rana Jahanban‐Esfahlan
    Journal of Cellular Physiology.2019; 234(12): 21758.     CrossRef
  • Serum-based soluble markers differentiate psoriatic arthritis from osteoarthritis
    Vinod Chandran, Fatima Abji, Anthony V Perruccio, Rajiv Gandhi, Suzanne Li, Richard J Cook, Dafna D Gladman
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  • Telmisartan prevents diet-induced obesity and preserves leptin transport across the blood-brain barrier in high-fat diet-fed mice
    Franziska Schuster, Gianna Huber, Ines Stölting, Emily E. Wing, Kathrin Saar, Norbert Hübner, William A. Banks, Walter Raasch
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    Juergen Kratzsch, Yoon Ju Bae, Wieland Kiess
    Best Practice & Research Clinical Endocrinology & Metabolism.2018; 32(1): 27.     CrossRef
  • Addressing the Perfect Storm: Biomarkers in Obesity and Pathophysiology of Cardiometabolic Risk
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  • Adipocytokine Involvement in Innate Immune Mechanisms
    Paulina Żelechowska, Elżbieta Kozłowska, Joanna Pastwińska, Justyna Agier, Ewa Brzezińska-Błaszczyk
    Journal of Interferon & Cytokine Research.2018; 38(12): 527.     CrossRef
  • The effect of a garlic supplement on the pro-inflammatory adipocytokines, resistin and tumor necrosis factor-alpha, and on pain severity, in overweight or obese women with knee osteoarthritis
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    Phytomedicine.2018; 48: 70.     CrossRef
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  • Usefulness of the Adipokines as Biomarkers of Ischemic Cardiac Dysfunction
    Larisa-Diana Mocan Hognogi, Cerasela-Mihaela Goidescu, Anca-Daniela Farcaş
    Disease Markers.2018; 2018: 1.     CrossRef
  • Circulating fibroblast growth factor 21 in patients with liver cirrhosis
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    Clinical and Experimental Medicine.2018; 18(1): 63.     CrossRef
  • Association of Cord Blood Resistin with Neonatal Birth Weight and Gestational Age
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    Journal of Comprehensive Pediatrics.2018;[Epub]     CrossRef
  • Major Adipokines and the −420C>G Resistin Gene Polymorphism as Predictors of Acute Ischemic Stroke Severity and In-Hospital Outcome
    Styliani D. Bouziana, Konstantinos Tziomalos, Antonios Goulas, Timoleon-Achilleas Vyzantiadis, Athanasia Panderi, Apostolos Ι. Ηatzitolios
    Journal of Stroke and Cerebrovascular Diseases.2018; 27(4): 963.     CrossRef
  • Resistin and NGAL are associated with inflammatory response, endothelial activation and clinical outcomes in sepsis
    Stephen P. J. Macdonald, Erika Bosio, Claire Neil, Glenn Arendts, Sally Burrows, Lisa Smart, Simon G. A. Brown, Daniel M. Fatovich
    Inflammation Research.2017; 66(7): 611.     CrossRef
  • Reference values for fasting serum resistin in healthy children and adolescents
    Ulrik Lausten-Thomsen, Michael Christiansen, Paula Louise Hedley, Tenna Ruest Haarmark Nielsen, Cilius Esmann Fonvig, Oluf Pedersen, Torben Hansen, Jens-Christian Holm
    Clinica Chimica Acta.2017; 469: 161.     CrossRef
  • Sarcopenic obesity or obese sarcopenia: A cross talk between age-associated adipose tissue and skeletal muscle inflammation as a main mechanism of the pathogenesis
    Alexander Kalinkovich, Gregory Livshits
    Ageing Research Reviews.2017; 35: 200.     CrossRef
  • Is There Any Relationship between Plasma 25-Hydroxyvitamin D3, Adipokine Profiles and Excessive Body Weight in Type 2 Diabetic Patients?
    Joanna Kocot, Piotr Dziemidok, Małgorzata Kiełczykowska, Jacek Kurzepa, Grzegorz Szcześniak, Irena Musik
    International Journal of Environmental Research and Public Health.2017; 15(1): 19.     CrossRef
  • Exogenous Adipokine Peptide Resistin Protects Against Focal Cerebral Ischemia/Reperfusion Injury in Mice
    Jiangtao Zhu, Di Wu, Chenyu Zhao, Man Luo, Ronald C. Hamdy, Balvin H. L. Chua, Xingshun Xu, Zhigang Miao
    Neurochemical Research.2017; 42(10): 2949.     CrossRef
  • Adipokines in Liver Cirrhosis
    Christa Buechler, Elisabeth Haberl, Lisa Rein-Fischboeck, Charalampos Aslanidis
    International Journal of Molecular Sciences.2017; 18(7): 1392.     CrossRef
  • The role of sex steroids in white adipose tissue adipocyte function
    A E Newell-Fugate
    Reproduction.2017; 153(4): R133.     CrossRef
  • Odanacatib Inhibits Resistin-induced Cardiomyocyte Hypertrophy Through the Inactivation of ERK Signaling Pathway
    Xian Zheng, Guanchang Cheng, Jianwei Luo, Qunhui Ye, Yongzhi Deng, Lin Wu
    International Journal of Pharmacology.2017; 13(2): 212.     CrossRef
  • Linking resistin, inflammation, and cardiometabolic diseases
    Hyeong Kyu Park, Mi Kyung Kwak, Hye Jeong Kim, Rexford S. Ahima
    The Korean Journal of Internal Medicine.2017; 32(2): 239.     CrossRef
  • Translating the biology of adipokines in atherosclerosis and cardiovascular diseases: Gaps and open questions
    M. Ruscica, A. Baragetti, A.L. Catapano, G.D. Norata
    Nutrition, Metabolism and Cardiovascular Diseases.2017; 27(5): 379.     CrossRef
  • Differences in Mean Levels of Maternal Resistin Serum between Early Onset Preeclampsia (EOPE) and Late Onset Preeclampsia (LOPE)
    Yusrawati ., P. Alfajra, R. Machmud
    Research Journal of Obstetrics and Gynecology.2016; 10(1): 1.     CrossRef
  • Secret talk between adipose tissue and central nervous system via secreted factors—an emerging frontier in the neurodegenerative research
    Avinash Parimisetty, Anne-Claire Dorsemans, Rana Awada, Palaniyandi Ravanan, Nicolas Diotel, Christian Lefebvre d’Hellencourt
    Journal of Neuroinflammation.2016;[Epub]     CrossRef
  • The role of adipokines in ischemic stroke risk stratification
    Styliani Bouziana, Konstantinos Tziomalos, Antonios Goulas, Apostolos Ι Ηatzitolios
    International Journal of Stroke.2016; 11(4): 389.     CrossRef
  • The endocrine function of human placenta: an overview
    Mariana A. Costa
    Reproductive BioMedicine Online.2016; 32(1): 14.     CrossRef
  • Ursolic acid plays a protective role in obesity-induced cardiovascular diseases
    Yu-Ting Lin, Ya-Mei Yu, Weng-Cheng Chang, Su-Yin Chiang, Hsu-Chin Chan, Ming-Fen Lee
    Canadian Journal of Physiology and Pharmacology.2016; 94(6): 627.     CrossRef
  • Determinants of body weight regulation in humans
    Milene Moehlecke, Luis Henrique Canani, Lucas Oliveira Junqueira e Silva, Manoel Roberto Maciel Trindade, Rogerio Friedman, Cristiane Bauermann Leitão
    Archives of Endocrinology and Metabolism.2016; 60(2): 152.     CrossRef
  • Sitagliptin decreases ventricular arrhythmias by attenuated glucose-dependent insulinotropic polypeptide (GIP)-dependent resistin signalling in infarcted rats
    Tsung-Ming Lee, Wei-Ting Chen, Nen-Chung Chang
    Bioscience Reports.2016;[Epub]     CrossRef
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    J.-P. Bastard, C. Bastard, S. Fellahi, C. Vatier, J. Capeau, B. Fève
    Obésité.2016; 11(3): 181.     CrossRef
  • Factors that promote macrophage homing to adipose tissue in metabolic syndrome
    Ishwarlal Jialal, Beverley Adams-Huet, Sridevi Devaraj
    Journal of Diabetes and its Complications.2016; 30(8): 1434.     CrossRef
  • Uncovering Factors Related to Pancreatic Beta-Cell Function
    Aoife M. Curran, Miriam F. Ryan, Elaine Drummond, Eileen R. Gibney, Michael J. Gibney, Helen M. Roche, Lorraine Brennan, Nigel Irwin
    PLOS ONE.2016; 11(8): e0161350.     CrossRef
  • Resistin’s, obesity and insulin resistance: the continuing disconnect between rodents and humans
    X. Huang, Z. Yang
    Journal of Endocrinological Investigation.2016; 39(6): 607.     CrossRef
  • Adipocytokines in renal transplant recipients
    Kristof Nagy, Shankar Prasad Nagaraju, Connie M. Rhee, Zoltan Mathe, Miklos Z. Molnar
    Clinical Kidney Journal.2016; 9(3): 359.     CrossRef
  • Endocrine alterations from concentric vs. eccentric muscle actions: A brief review
    Robert R. Kraemer, V. Daniel Castracane
    Metabolism.2015; 64(2): 190.     CrossRef
  • Non-traditional cytokines: How catecholamines and adipokines influence macrophages in immunity, metabolism and the central nervous system
    Mark A. Barnes, Monica J. Carson, Meera G. Nair
    Cytokine.2015; 72(2): 210.     CrossRef
  • Local and serum levels of adipokines in patients with obesity after periodontal therapy: one‐year follow‐up
    Tiago Eduardo Dias Gonçalves, Glaucia Santos Zimmermann, Luciene Cristina Figueiredo, Monique de Carvalho Souza, Daniele Ferreira da Cruz, Marta Ferreira Bastos, Hélio Doyle Pereira da Silva, Poliana Mendes Duarte
    Journal of Clinical Periodontology.2015; 42(5): 431.     CrossRef
  • Newborn Adipokines and Birth Outcomes
    Edwina H. Yeung, Alexander C. McLain, Nancy Anderson, David Lawrence, Nansi S. Boghossian, Charlotte Druschel, Erin Bell
    Paediatric and Perinatal Epidemiology.2015; 29(4): 317.     CrossRef
  • The effect of a preparation of minerals, vitamins and trace elements on the cardiac gene expression pattern in male diabetic rats
    Márta Sárközy, Gergő Szűcs, Márton Pipicz, Ágnes Zvara, Katalin Éder, Veronika Fekete, Csilla Szűcs, Judit Bárkányi, Csaba Csonka, László G. Puskás, Csaba Kónya, Péter Ferdinandy, Tamás Csont
    Cardiovascular Diabetology.2015;[Epub]     CrossRef
  • Diet-induced variability of the resistin gene (Retn) transcript level and methylation profile in rats
    Joanna Nowacka-Woszuk, Ewa Pruszynska-Oszmalek, Maciej Szydlowski, Slawomir Sadkowski, Izabela Szczerbal
    BMC Genetics.2015;[Epub]     CrossRef
  • INFLUENCE OF RESISTIN ON THE COURSE OF ISCHEMIC HEART DISEASE IN PATIENTS WITH TYPE 2 DIABETES MELLITUS
    A. T. Teplyakov, Sh. D. Akhmedov, T. Ye. Suslova, А. V. Andriyanova, A. V. Kuznetsova, N. V. Protopopova, V. V. Kalyuzhin, O. N. Nasanova
    Bulletin of Siberian Medicine.2015; 14(5): 73.     CrossRef
  • The Effects of a Single Developmentally Entrained Pulse of Testosterone in Female Neonatal Mice on Reproductive and Metabolic Functions in Adult Life
    Hyeran Jang, Shalender Bhasin, Tyler Guarneri, Carlo Serra, Mary Schneider, Mi-Jeong Lee, Wen Guo, Susan K. Fried, Karol Pencina, Ravi Jasuja
    Endocrinology.2015; 156(10): 3737.     CrossRef
  • The Resin fromProtium heptaphyllumPrevents High-Fat Diet-Induced Obesity in Mice: Scientific Evidence and Potential Mechanisms
    Karine Maria Martins Bezerra Carvalho, José Delano Barreto Marinho Filho, Tiago Sousa de Melo, Ana Jérsia Araújo, Josiane da Silva Quetz, Maria do Perpétuo Socorro Saldanha da Cunha, Karina Moura de Melo, Armenio Andre de Carvalho Almeida da Silva, Adrian
    Evidence-Based Complementary and Alternative Medicine.2015; 2015: 1.     CrossRef
  • Evolution of the Vertebrate Resistin Gene Family
    Qingda Hu, Huanran Tan, David M. Irwin, Marc Robinson-Rechavi
    PLOS ONE.2015; 10(6): e0130188.     CrossRef
  • Obesity, adipokines and neuroinflammation
    Argel Aguilar-Valles, Wataru Inoue, Christoph Rummel, Giamal N. Luheshi
    Neuropharmacology.2015; 96: 124.     CrossRef
  • Adipokines at the crossroad between obesity and cardiovascular disease
    Filippo Molica, Sandrine Morel, Brenda Kwak, Françoise Rohner-Jeanrenaud, Sabine Steffens
    Thrombosis and Haemostasis.2015; 113(03): 553.     CrossRef
  • Resistin – 420 C/G polymorphism and serum resistin level in Iranian patients with gestational diabetes mellitus
    Mohammad Ali Takhshid, Zinab Zare
    Journal of Diabetes & Metabolic Disorders.2015;[Epub]     CrossRef
  • Ictal adipokines are associated with pain severity and treatment response in episodic migraine
    Nu Cindy Chai, Bizu Gelaye, Gretchen E. Tietjen, Paul D. Dash, Barbara A. Gower, Linda W. White, Thomas N. Ward, Ann I. Scher, B. Lee Peterlin
    Neurology.2015; 84(14): 1409.     CrossRef
  • Inflammation and insulin/IGF-1 resistance as the possible link between obesity and neurodegeneration
    Lindsay J. Spielman, Jonathan P. Little, Andis Klegeris
    Journal of Neuroimmunology.2014; 273(1-2): 8.     CrossRef
  • Wild Blueberries (Vaccinium myrtillus) Alleviate Inflammation and Hypertension Associated with Developing Obesity in Mice Fed with a High-Fat Diet
    Otto T. Mykkänen, Anne Huotari, Karl-Heinz Herzig, Thomas W. Dunlop, Hannu Mykkänen, Pirkka V. Kirjavainen, Michael Müller
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  • Role of fat and adipokines in intestinal inflammation
    LeaI Kredel, Arvind Batra, Britta Siegmund
    Current Opinion in Gastroenterology.2014; 30(6): 559.     CrossRef
  • 13C metabolic flux analysis shows that resistin impairs the metabolic response to insulin in L6E9 myotubes
    Shirley Guzmán, Silvia Marin, Anibal Miranda, Vitaly A Selivanov, Josep J Centelles, Romain Harmancey, Fatima Smih, Annie Turkieh, Yves Durocher, Antonio Zorzano, Philippe Rouet, Marta Cascante
    BMC Systems Biology.2014;[Epub]     CrossRef
  • Bee Pollen Improves Muscle Protein and Energy Metabolism in Malnourished Old Rats through Interfering with the Mtor Signaling Pathway and Mitochondrial Activity
    Jérôme Salles, Nicolas Cardinault, Véronique Patrac, Alexandre Berry, Christophe Giraudet, Marie-Laure Collin, Audrey Chanet, Camille Tagliaferri, Philippe Denis, Corinne Pouyet, Yves Boirie, Stéphane Walrand
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