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1 "Immunoglobulin E"
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Original Article
Metabolic Risk/Epidemiology
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Insulin Resistance Increases Serum Immunoglobulin E Sensitization in Premenopausal Women
Seung Eun Lee, Ji Yeon Baek, Kyungdo Han, Eun Hee Koh
Diabetes Metab J. 2021;45(2):175-182.   Published online April 14, 2020
DOI: https://doi.org/10.4093/dmj.2019.0150
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  • 2 Crossref
Graphical AbstractGraphical Abstract AbstractAbstract PDFPubReader   ePub   
Background

Although studies have shown that obesity is associated with aeroallergen sensitization (atopy), controversy still exists. We aimed to investigate the association between metabolic status, obesity, and atopy stratified by sex and menopausal status.

Methods

A total of 1,700 adults from the 2010 Korean National Health and Nutrition Examination Survey were classified into metabolically healthy nonobese (MHNO), metabolically unhealthy nonobese (MUNO), metabolically healthy obese (MHO), and metabolically unhealthy obese (MUO) by body mass index and insulin resistance. Atopy was defined as a positive response to at least one aeroallergen. Multiple regression analysis was used to evaluate the risk of immunoglobulin E (IgE) elevation or atopy in relation to the degree of metabolic abnormality and obesity.

Results

In premenopausal women, total IgE was positively correlated with obesity and insulin resistance. MUNO participants had a higher risk of having elevated total IgE compared to MHNO participants (odds ratio [OR], 2.271; 95% confidence interval [CI], 1.201 to 4.294), while MHO participants did not show a significant difference (OR, 1.435; 95% CI, 0.656 to 3.137) in premenopausal women. MUNO, but not MHO was also associated with atopy (OR, 2.157; 95% CI, 1.284 to 3.625). In men and postmenopausal women, there was no significant difference between metabolic status, obesity, and atopy among groups.

Conclusion

Increased insulin resistance is associated with total IgE and atopy in premenopausal women but not in postmenopausal women or men.

Citations

Citations to this article as recorded by  
  • Association of serum total IgE and allergen-specific IgE with insulin resistance in adolescents: an analysis of the NHANES database
    Yaping Liu, Xiaoxia Wang, Yong Liu
    BMC Pediatrics.2024;[Epub]     CrossRef
  • Is There a Relationship between Insulin Resistance and Eosinophil, Inflammatory Parameters Neutrophil to lymphocyte ratio, C-Reactive Protein Values?
    Meltem YİĞİT, Özgür OLUKMAN
    Medical Records.2024; 6(1): 32.     CrossRef

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