Diabetes & Metabolism Journal

Original Articles

Basic and Translational Research
Aerobic Exercise Stabilizes HIF1α through P4HA1 to Activate Nrf2/GPX4 Inhibiting Ferroptosis and Attenuating Diabetic Cardiomyopathy: Sicong Xie, Mingjun Wang, Chenshuo Yu, Fei Zhou, Yu Zheng, Ning Zhang, Yushan Chen, Weihan Kong, Wenzhe Si, Jiaxuan Xu, Yang Zhang, Lei Wang; Received June 5, 2025 Accepted November 24, 2025 Published online March 18, 2026; DOI: https://doi.org/10.4093/dmj.2025.0495 [Epub ahead of print]

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Background
Diabetic cardiomyopathy (DCM) is a severe complication of end-stage diabetes characterised by cardiac hypertrophy and heart failure. Previous studies have shown that aerobic exercise enhances the body’s antioxidant capacity, protects the heart, and alleviates DCM-mediated heart damage; however, the specific mechanism remains unclear. The aim of this study was to investigate the protective effects and underlying mechanisms of aerobic exercise against DCM.
Methods
Rat cardiomyocytes (H9C2) were cultivated in vitro and stimulated with high glucose and palmitic acid to assess cell death, mitochondrial activity, oxidative stress indicators, mitochondrial morphology, and ferroptosis-related proteins. A DCM rat model was established to evaluate cardiac function, myocardial enzyme levels and pathology, collagen, and ferroptosis-related proteins in each group. Bioinformatics analysis was used to identify the roles of prolyl 4-hydroxylase subunit alpha 1 (P4HA1) and hypoxia inducible factor 1 subunit alpha (HIF1α) in regulating ferroptosis. Overexpression and knockdown of P4HA1 and HIF1α were used to further validate the relevant mechanisms.
Results
DCM occurrence and development were closely linked to ferroptosis. Alongside apoptosis and necrosis, ferroptosis is characterised mainly by mitochondrial changes, the appearance of lipid peroxides, and increased reactive oxygen species in myocardial cells or tissues. Expression levels of ferroptosis-related proteins were significantly altered, but improved by aerobic exercise. Using bioinformatics and immunoprecipitation, we found that aerobic exercise reduces HIF1α ubiquitination by activating P4HA1. The HIF1α accumulation activates the nuclear factor erythroid 2-related factor 2 (Nrf2)/glutathione peroxidase 4 (GPX4) signaling pathway, inhibiting ferroptosis.
Conclusion
In summary, aerobic exercise increases P4HA1 expression and inhibits HIF1α hydroxylation, preventing its ubiquitination and degradation. This consequently activates the Nrf2/GPX4 signaling pathway, further exerting antioxidant effects, attenuating ferroptosis, and ultimately ameliorating DCM.

Citations

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Does exercise modulate ferroptosis-related cardiovascular injury? Mechanistic evidence and translational boundaries
Mengzhao Han, Haoran Huang, Yang Li, Lan Wang, Long Ji, Haibing Yin, Penglei Fan, Xinguo Yuan
Frontiers in Physiology.2026;[Epub] CrossRef
Collagen Prolyl 4-Hydroxylase: An Emerging Key Player in Cardiac Fibrosis
Wei Hua, Zai-Xin Yu, Li-Huang Zha
Journal of Cardiovascular Translational Research.2026;[Epub] CrossRef
The Health Benefits of Exercise: Molecular and Cellular Mechanisms
Peifeng Ying, Huilin Wang, Xiu Lu, Wenjuan Zhang, Zhehao Lin, Kai Wang, Shangxuan Li, Lu Chen, Mingchao Jiang, Sarkawt Hamad, Yi Wang, Jianmin Wu, Shukuan Ling
MedComm.2026;[Epub] CrossRef

Complications
BDH1 Protects against Diabetic Cardiomyopathy by Improving Mitochondrial Function and Suppressing Cardiomyocyte Apoptosis Via Activation of the AKT/GSK3β Pathway: Yan Wang, Yanan Cheng, Jianbo Wu, Yu Zhao, Di Wang, Longyan Yang, Dong Zhao; Received March 26, 2025 Accepted September 8, 2025 Published online January 19, 2026; DOI: https://doi.org/10.4093/dmj.2025.0257 [Epub ahead of print]

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Background
Diabetic cardiomyopathy (DCM) is the main cause of heart failure in diabetes patients with no effective therapies currently available. A deeper understanding of the mechanisms underlying DCM is essential for identifying novel therapeutic targets.
Methods
DCM model was established in C57BL/6J mice by administering multiple low-dose intraperitoneal injections of streptozotocin (STZ) in combination with a high-fat diet (HFD). Proteomic profiling was conducted on cardiac tissues from control and DCM mice to identify differentially expressed proteins. The expression of β-hydroxybutyrate dehydrogenase 1 (BDH1, also known as 3-hydroxybutyrate dehydrogenase) in cardiac tissues and cardiomyocyte were determined by immunoblot and quantitative polymerase chain reaction. The function and mechanism of BDH1 in DCM were investigated using a cardiac-specific BDH1-overexpressing mouse model, combined with cardiomyocyte cell lines with either BDH1 overexpression or knockdown.
Results
BDH1 was markedly downregulated in cardiac tissues of DCM mice, as well as in cardiomyocytes treated with high glucose and palmitic acid (HGPA). Cardiac-specific overexpression of BDH1 markedly improved cardiac dysfunction and myocardial fibrosis in DCM mice. In vitro, BDH1 overexpression attenuated mitochondrial damage and inhibited apoptosis in cardiomyocytes induced by HGPA. Conversely, BDH1 knockdown exacerbated these pathological changes under HGPA conditions. Transcriptome analysis linked BDH1 expression to the phosphatidylinositol 3-kinase (PI3K)-protein kinase B (AKT) pathway, and we confirmed that BDH1 overexpression reversed diabetes-induced inhibition of the AKT/glycogen synthase kinase 3β (GSK3β) pathway. The protective effects of BDH1 on mitochondrial function and cardiomyocytes apoptosis were abolished following treatment with AKT inhibitor (AKTi). Cardiac-specific overexpression of BDH1 markedly decreased β-hydroxybutyric acid (BHB, the predominant ketone body) levels in cardiac tissues of DCM mice. Elevated BHB levels suppressed AKT activation in cardiomyocytes, while BDH1 overexpression effectively restored AKT/GSK3β pathway activity and ameliorated BHB-induced mitochondrial dysfunction and cardiomyocytes apoptosis.
Conclusion
Our study demonstrates that BDH1 plays a protective role in DCM by regulating BHB level and activating the AKT/GSK3β pathway, thereby mitigating mitochondrial damage and cardiomyocyte apoptosis. BDH1 may be a promising therapeutic target for DCM.

Citations

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Cellular Senescence in Diabetic Cardiomyopathy: Mechanistic Insights and Therapeutic Perspectives
Ting Ye, Donglin Yang, Xinrui Chang, Dongdong Wu, Yuman Lei, Chengcheng Mu, Yizhe Zhao, Shouzhu Xu
Cardiovascular Drugs and Therapy.2026;[Epub] CrossRef

Basic Research
Diabetes Promotes Myocardial Fibrosis via AMPK/EZH2/PPAR-γ Signaling Pathway: Shan-Shan Li, Lu Pan, Zhen-Ye Zhang, Meng-Dan Zhou, Xu-Fei Chen, Ling-Ling Qian, Min Dai, Juan Lu, Zhi-Ming Yu, Shipeng Dang, Ru-Xing Wang; Diabetes Metab J. 2024;48(4):716-729. Published online February 27, 2024; DOI: https://doi.org/10.4093/dmj.2023.0031

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Background
Diabetes-induced cardiac fibrosis is one of the main mechanisms of diabetic cardiomyopathy. As a common histone methyltransferase, enhancer of zeste homolog 2 (EZH2) has been implicated in fibrosis progression in multiple organs. However, the mechanism of EZH2 in diabetic myocardial fibrosis has not been clarified.
Methods
In the current study, rat and mouse diabetic model were established, the left ventricular function of rat and mouse were evaluated by echocardiography and the fibrosis of rat ventricle was evaluated by Masson staining. Primary rat ventricular fibroblasts were cultured and stimulated with high glucose (HG) in vitro. The expression of histone H3 lysine 27 (H3K27) trimethylation, EZH2, and myocardial fibrosis proteins were assayed.
Results
In STZ-induced diabetic ventricular tissues and HG-induced primary ventricular fibroblasts in vitro, H3K27 trimethylation was increased and the phosphorylation of EZH2 was reduced. Inhibition of EZH2 with GSK126 suppressed the activation, differentiation, and migration of cardiac fibroblasts as well as the overexpression of the fibrotic proteins induced by HG. Mechanical study demonstrated that HG reduced phosphorylation of EZH2 on Thr311 by inactivating AMP-activated protein kinase (AMPK), which transcriptionally inhibited peroxisome proliferator-activated receptor γ (PPAR-γ) expression to promote the fibroblasts activation and differentiation.
Conclusion
Our data revealed an AMPK/EZH2/PPAR-γ signal pathway is involved in HG-induced cardiac fibrosis.

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International Journal of Molecular Sciences.2026; 27(2): 983. CrossRef
Aerobic Exercise Stabilizes HIF1α through P4HA1 to Activate Nrf2/GPX4 Inhibiting Ferroptosis and Attenuating Diabetic Cardiomyopathy
Sicong Xie, Mingjun Wang, Chenshuo Yu, Fei Zhou, Yu Zheng, Ning Zhang, Yushan Chen, Weihan Kong, Wenzhe Si, Jiaxuan Xu, Yang Zhang, Lei Wang
Diabetes & Metabolism Journal.2026;[Epub] CrossRef
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Review

Pathophysiology
Primordial Drivers of Diabetes Heart Disease: Comprehensive Insights into Insulin Resistance: Yajie Fan, Zhipeng Yan, Tingting Li, Aolin Li, Xinbiao Fan, Zhongwen Qi, Junping Zhang; Diabetes Metab J. 2024;48(1):19-36. Published online January 3, 2024; DOI: https://doi.org/10.4093/dmj.2023.0110

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Insulin resistance has been regarded as a hallmark of diabetes heart disease (DHD). Numerous studies have shown that insulin resistance can affect blood circulation and myocardium, which indirectly cause cardiac hypertrophy and ventricular remodeling, participating in the pathogenesis of DHD. Meanwhile, hyperinsulinemia, hyperglycemia, and hyperlipidemia associated with insulin resistance can directly impair the metabolism and function of the heart. Targeting insulin resistance is a potential therapeutic strategy for the prevention of DHD. Currently, the role of insulin resistance in the pathogenic development of DHD is still under active research, as the pathological roles involved are complex and not yet fully understood, and the related therapeutic approaches are not well developed. In this review, we describe insulin resistance and add recent advances in the major pathological and physiological changes and underlying mechanisms by which insulin resistance leads to myocardial remodeling and dysfunction in the diabetic heart, including exosomal dysfunction, ferroptosis, and epigenetic factors. In addition, we discuss potential therapeutic approaches to improve insulin resistance and accelerate the development of cardiovascular protection drugs.

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Belma Turan, Yasemin Atici, Deniz Billur
Canadian Journal of Physiology and Pharmacology.2026; 104: 1. CrossRef
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Hui Li, Ruiyin Zeng, Jing Liu, Huiwen Wang
Journal of Diabetes & Metabolic Disorders.2026;[Epub] CrossRef
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Hyeong Rok Yun, Manish Kumar Singh, Sunhee Han, Jyotsna S. Ranbhise, Joohun Ha, Sung Soo Kim, Insug Kang
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Qinxue Li, Guyu Zeng, Deshan Yuan, Tianyu Li, Peizhi Wang, Ce Zhang, Sida Jia, Pei Zhu, Ying Song, Xiaofang Tang, Ping Liu, Yuejin Yang, Runlin Gao, Jingjing Xu, Xueyan Zhao, Jinqing Yuan
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International Journal of Molecular Medicine.2026; 57(4): 1. CrossRef
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Biomedicines.2026; 14(2): 394. CrossRef
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Xiandu Jin, Yurong Feng, Chang Liu, Tianwei Cheng, Yanye Jin, Zibin Shao, Yongyu Bian, Hao Wu, Jiao Li, Yue Liu, Liping Wei, Zhi Qi, Xin Qi
Cardiovascular Diabetology.2026;[Epub] CrossRef
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Afolake Arowolo, Oluyomi Adeyemi, Toluwalope Ajonijebu, Aminu Musa, Hygon Mutavhatsindi, Rabia Johnson, Kenechukwu Obikeze
Biomedicine & Pharmacotherapy.2026; 198: 119354. CrossRef
Clinical evidence of exercise intervention in improving adults with type 2 diabetes mellitus and frailty: a narrative literature review
Xiuli Mo, Zhengyu Duan, Weihong Zhang, Yongliang Jia
Frontiers in Physiology.2026;[Epub] CrossRef
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Kai Chen, Yiqing Nong, Ying Liu, Ziming Ye
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Haoqing Ren, Hengli Lai
Frontiers in Clinical Diabetes and Healthcare.2026;[Epub] CrossRef
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Duo Yang, Renzhe Lin, Sen Li, Shujun Ye, Zitian Luo, Huankai Zhang, Si Wu, Longsheng Zhang
Frontiers in Nutrition.2026;[Epub] CrossRef
Association between the Single-Point Insulin Sensitivity Estimator and Future Cardiovascular Disease Risk in a Population with Cardiovascular-Kidney-Metabolic Syndrome Stage 0 - 3: A Nationwide Prospective Cohort Study
Yuhuan Li, Junli Xue
Journal of Biosciences and Medicines.2026; 14(06): 189. CrossRef
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Mahshid Zamani, AhmadAli Jalalinezhad, Nepton Soltani
Neuroscience & Biobehavioral Reviews.2026; 188: 106842. CrossRef
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Diabetes Research and Clinical Practice.2026; 239: 113432. CrossRef
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Cheng-Wen He, Xiaohuan Guo, Tao Liang, Pan Chen, Kaiqiang Li, Aibo Xu, Ke Hao, Ning Hu, Zhen Wang
Microsystems & Nanoengineering.2026;[Epub] CrossRef
Insulin sensitivity and cardiovascular risk after revascularization: associations with remodeling and long-term outcomes
Ruixuan Tang, Rui Xi, Xiao Zong, Roubai Pan, Suyi Jia, Yan Xu, Rong Tao, Qin Fan
Frontiers in Cardiovascular Medicine.2026;[Epub] CrossRef
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Luying Qi, Shumin Zhang, Bin Wang, Mei Yang, Yuanbin Li, Baiwang Li, Jingnan Xue, Xuemei Li
Frontiers in Endocrinology.2026;[Epub] CrossRef
Associations of cumulative exposure and control patterns of the single-point insulin sensitivity estimator with incident cardiovascular disease in middle-aged and older Chinese adults with dysglycemia
Hao Li, Lingyan Hu, Chuanxin Zou
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Antioxidants.2026; 15(9): 1206. CrossRef
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Seung-Hwan Lee, Kyu Na Lee, Jong-Chan Youn, Hun Sung Kim, Kyungdo Han, Mee Kyoung Kim
Diabetes & Metabolism Journal.2025; 49(1): 105. CrossRef
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Lipids in Health and Disease.2025;[Epub] CrossRef
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Pegah Bahrami, Kelly A. Aromolaran, Ademuyiwa S. Aromolaran
Journal of Cellular Physiology.2025;[Epub] CrossRef
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Diabetology & Metabolic Syndrome.2025;[Epub] CrossRef
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Caixia Chen, Hui Gao, Ying Wei, Yaxi Wang
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Cell Biochemistry and Biophysics.2025; 83(4): 4415. CrossRef
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Pu-Hua Zhang, Nuo-Nan Li, Xiang Gu, Chun-Xia Zhou, Zhen-Zhen Jiang, Xian-Jun Luo, Hong-Wen Zhu, Xiao-Yong Zhu
Frontiers in Endocrinology.2025;[Epub] CrossRef
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International Journal of Nanomedicine.2025; Volume 20: 7295. CrossRef
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Sanjay, Hae-Jeung Lee
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Bing Xiao, Xin Chen, Ruiyu Zong, Yiming Guan, Zhu Zhu, Siling Bi
Frontiers in Microbiology.2025;[Epub] CrossRef
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Kun Liu, Jinling Hu, Yueqing Huang, Dingliu He, Jing Zhang
Cardiovascular Diabetology.2025;[Epub] CrossRef
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Zheng Zhang, Huijie Xu, Runjia Zhang, Yangxinyu Yan, Xi Ling, Yun Meng, Xilin Zhang, Yuanyuan Wang
Nature Communications.2025;[Epub] CrossRef
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Cytokine.2025; 194: 156998. CrossRef
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Jun Wang, Chao Tang, Zhijie Xie, Amirmohammad Khalaji
PLOS One.2025; 20(7): e0329234. CrossRef
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Ningyi Cheng, Zhicheng Ma, Yukun Chen, Lei Jin, Liangwan Chen
Scientific Reports.2025;[Epub] CrossRef
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Scripta Medica.2025; 56(6): 695. CrossRef
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Xi Wu, Mingxing Wu, Haobo Huang, Zhe Liu, He Huang, Lei Wang
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Original Article

Basic Research
Pharmacologic Activation of Angiotensin-Converting Enzyme II Alleviates Diabetic Cardiomyopathy in db/db Mice by Reducing Reactive Oxidative Stress: Donghyun Kim, Wooju Jeong, Yumin Kim, Jibeom Lee, Sung Woo Cho, Chang-Myung Oh, Raekil Park; Diabetes Metab J. 2023;47(4):487-499. Published online April 25, 2023; DOI: https://doi.org/10.4093/dmj.2022.0125

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Background
Diabetes mellitus is one of the most common chronic diseases worldwide, and cardiovascular disease is the leading cause of morbidity and mortality in diabetic patients. Diabetic cardiomyopathy (DCM) is a phenomenon characterized by a deterioration in cardiac function and structure, independent of vascular complications. Among many possible causes, the renin-angiotensin-aldosterone system and angiotensin II have been proposed as major drivers of DCM development. In the current study, we aimed to investigate the effects of pharmacological activation of angiotensin-converting enzyme 2 (ACE2) on DCM.
Methods
The ACE2 activator diminazene aceturate (DIZE) was administered intraperitoneally to male db/db mice (8 weeks old) for 8 weeks. Transthoracic echocardiography was used to assess cardiac mass and function in mice. Cardiac structure and fibrotic changes were examined using histology and immunohistochemistry. Gene and protein expression levels were examined using quantitative reverse transcription polymerase chain reaction and Western blotting, respectively. Additionally, RNA sequencing was performed to investigate the underlying mechanisms of the effects of DIZE and identify novel potential therapeutic targets for DCM.
Results
Echocardiography revealed that in DCM, the administration of DIZE significantly improved cardiac function as well as reduced cardiac hypertrophy and fibrosis. Transcriptome analysis revealed that DIZE treatment suppresses oxidative stress and several pathways related to cardiac hypertrophy.
Conclusion
DIZE prevented the diabetes mellitus-mediated structural and functional deterioration of mouse hearts. Our findings suggest that the pharmacological activation of ACE2 could be a novel treatment strategy for DCM.

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Reviews

Basic Research
Application of Animal Models in Diabetic Cardiomyopathy: Wang-Soo Lee, Jaetaek Kim; Diabetes Metab J. 2021;45(2):129-145. Published online March 25, 2021; DOI: https://doi.org/10.4093/dmj.2020.0285

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Diabetic heart disease is a growing and important public health risk. Apart from the risk of coronary artery disease or hypertension, diabetes mellitus (DM) is a well-known risk factor for heart failure in the form of diabetic cardiomyopathy (DiaCM). Currently, DiaCM is defined as myocardial dysfunction in patients with DM in the absence of coronary artery disease and hypertension. The underlying pathomechanism of DiaCM is partially understood, but accumulating evidence suggests that metabolic derangements, oxidative stress, increased myocardial fibrosis and hypertrophy, inflammation, enhanced apoptosis, impaired intracellular calcium handling, activation of the renin-angiotensin-aldosterone system, mitochondrial dysfunction, and dysregulation of microRNAs, among other factors, are involved. Numerous animal models have been used to investigate the pathomechanisms of DiaCM. Despite some limitations, animal models for DiaCM have greatly advanced our understanding of pathomechanisms and have helped in the development of successful disease management strategies. In this review, we summarize the current pathomechanisms of DiaCM and provide animal models for DiaCM according to its pathomechanisms, which may contribute to broadening our understanding of the underlying mechanisms and facilitating the identification of possible new therapeutic targets.

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Applied Sciences.2026; 16(2): 795. CrossRef
Investigating the biomarkers of diabetic-cardiomyopathy with the high mobility group box-1 as a potential anti-inflammatory therapeutic target: Systematic Review and meta-analysis
Ranmali Ranasinghe, Michael Mathai, Anthony Zulli
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Transcriptional regulatory network analysis uncovers modular gene control and potential key regulators in diabetic cardiomyopathy
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Frontiers in Cell and Developmental Biology.2026;[Epub] CrossRef
Modulation of the gut-heart axis by exercise in diabetic cardiomyopathy: Microbial mechanisms and clinical implications
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iScience.2026; 29(4): 115490. CrossRef
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Vasiliy A. Zolotarev, Vladimir O. Murovets, Egor A. Sozontov, Anastasia L. Sepp, Ekaterina A. Lukina, Raisa P. Khropycheva, Benjamin Thomas, Sergueï O. Fetissov
International Journal of Molecular Sciences.2026; 27(15): 6963. CrossRef
O-GlcNAc modification of CaMKII-mediated mitophagic flux regulation via HSPB8 in diabetic cardiomyopathy
Yanjuan Jiang, Kaibo Hu, Zhaowei Luo, Huiwen Duan, Xinrui Qi, Xuehong Zheng, Jing Zhang, Fang Zou, Xia Cai, Liyan Niu, Peng Yu, Xiaoyang Lai
Clinical Science.2026; 140(8): 1779. CrossRef
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Jie-qiong Zeng, Hui-fen Zhou, Hai-xia Du, Yu-jia Wu, Qian-ping Mao, Jun-jun Yin, Hai-tong Wan, Jie-hong Yang
Chinese Journal of Integrative Medicine.2025; 31(3): 251. CrossRef
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Branislav Kura, Lucia Kindernay, Dinender Singla, Ulrika Dulova, Monika Bartekova
American Journal of Physiology-Heart and Circulatory Physiology.2025; 328(4): H865. CrossRef
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Rima Kamel, Sibelle Kassouf, Selim M. Nasser, Amale Mcheik, Nathalie Hayeck, Elias Abi-Ramia, Hanan ElKazzaz, Christian Khalil, Aniella Abi-Gerges
Toxicology and Applied Pharmacology.2025; 499: 117319. CrossRef
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Matin Mohyadini, Aghele Fahimi, S. Zahra Bathaie, Hamid Yaghooti
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Pu-Hua Zhang, Nuo-Nan Li, Xiang Gu, Chun-Xia Zhou, Zhen-Zhen Jiang, Xian-Jun Luo, Hong-Wen Zhu, Xiao-Yong Zhu
Frontiers in Endocrinology.2025;[Epub] CrossRef
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Shuaiwang Huang, Zhanglin Chen, Haoming Li, Yunyi Zou, Bihan Wang, Wenjun Zhao, Lan Zheng, Zuoqiong Zhou, Xiyang Peng, Changfa Tang
Nutrients.2025; 17(13): 2209. CrossRef
Cross-regulation of methylation and oxidative stress: molecular mechanisms and intervention strategies of diabetic cardiomyopathy
Ya-qi Guo, Jia-yin Zhang, Pan-pan Hou, Chen-xi Jia, Tian-lu Zhu, Qi-rui Zhang, Zheng-wei Du, Dan-jie Li, Yu-ting Xi, Qian-qian Niu, Peng Li
European Journal of Pharmacology.2025; 1005: 178080. CrossRef
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Georgică Târtea, Aurel Popa-Wagner, Veronica Sfredel, Smaranda Ioana Mitran, Alexandra Oltea Dan, Anca-Maria Țucă, Alexandra Nicoleta Preda, Victor Raicea, Eugen Țieranu, Dragoș Cozma, Radu Vătășescu
International Journal of Molecular Sciences.2024; 25(4): 2118. CrossRef
Mitochondrial energy metabolism in diabetic cardiomyopathy: Physiological adaption, pathogenesis, and therapeutic targets
Wanlin Ye, Kun Han, Maodi Xie, Sheyu Li, Guo Chen, Yanyan Wang, Tao Li
Chinese Medical Journal.2024; 137(8): 936. CrossRef
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Pharmaceuticals.2024; 17(3): 374. CrossRef
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Abdul Quaiyoom, Ranjeet Kumar
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Yasodha Krishna Janapati, Sunil Junapudi
Animal Models and Experimental Medicine.2024; 7(3): 297. CrossRef
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Weixing Wen, Yue Cao, Peng Chen, Jiahuan Li, Weiwen Li, Guolin Huang, Haoxiao Zheng, Xiaolin Zhu, Hao Zhang, Yangxin Chen, Xiaohui Huang, Yunzhao Hu, Yuli Huang
Life Sciences.2024; 358: 123161. CrossRef
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International Journal of Heart Failure.2023; 5(1): 1. CrossRef
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Diabetes & Metabolism Journal.2023; 47(1): 10. CrossRef
Machine learning for spatial stratification of progressive cardiovascular dysfunction in a murine model of type 2 diabetes mellitus
Andrya J. Durr, Anna S. Korol, Quincy A. Hathaway, Amina Kunovac, Andrew D. Taylor, Saira Rizwan, Mark V. Pinti, John M. Hollander, Yoshihiro Fukumoto
PLOS ONE.2023; 18(5): e0285512. CrossRef
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Oxidative Medicine and Cellular Longevity.2022;[Epub] CrossRef
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Life Sciences.2021; 283: 119857. CrossRef

Cardiovascular Risk/Epidemiology
Epidemiology, Pathophysiology, Diagnosis and Treatment of Heart Failure in Diabetes: Jin Joo Park; Diabetes Metab J. 2021;45(2):146-157. Published online March 25, 2021; DOI: https://doi.org/10.4093/dmj.2020.0282; Correction in: Diabetes Metab J 2021;45(5):796

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The cardiovascular disease continuum begins with risk factors such as diabetes mellitus (DM), progresses to vasculopathy and myocardial dysfunction, and finally ends with cardiovascular death. Diabetes is associated with a 2- to 4-fold increased risk for heart failure (HF). Moreover, HF patients with DM have a worse prognosis than those without DM. Diabetes can cause myocardial ischemia via micro- and macrovasculopathy and can directly exert deleterious effects on the myocardium. Hyperglycemia, hyperinsulinemia, and insulin resistance can cause alterations in vascular homeostasis. Then, reduced nitric oxide and increased reactive oxygen species levels favor inflammation leading to atherothrombotic progression and myocardial dysfunction. The classification, diagnosis, and treatment of HF for a patient with and without DM remain the same. Until now, drugs targeting neurohumoral and metabolic pathways improved mortality and morbidity in HF with reduced ejection fraction (HFrEF). Therefore, all HFrEF patients should receive guideline-directed medical therapy. By contrast, drugs modulating neurohumoral activity did not improve survival in HF with preserved ejection fraction (HFpEF) patients. Trials investigating whether sodium-glucose cotransporter-2 inhibitors are effective in HFpEF are on-going. This review will summarize the epidemiology, pathophysiology, and treatment of HF in diabetes.

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World Journal of Cardiology.2026;[Epub] CrossRef
Cardiomyocyte calcium homeostasis remodeling in diabetes-related HFpEF: mechanisms and therapeutic perspectives
Kexin Zhang, Jiaxuan Lan, Yan Leng, Zhong-yuan Xia
Pharmacological Research.2026; 232: 108434. CrossRef
Mediating roles of systemic immune-inflammation index and body mass index in the association between dietary inflammatory index and cardiovascular disease in diabetes
Shaofang Tang, Hongtao Li, Zixun Wang, Baoping Wang, Zhiqing Li, Yin Li, Chenlin Dai
Medicine.2026; 105(37): e50622. CrossRef
Multivariate Machine Learning Model for Long‐Term Risk Prediction of Acute Coronary Syndrome in Patients With Heart Failure With Preserved Ejection Fraction and Obstructive Sleep Apnea
YiJun Wang, Yanan Xu, Jin Peng, Menglei Hao, Liying Huang, Zhuoya Yao, Huaiyu Ruan, Junjie Leng, Wenyuan Yin, Yi Yang, Jun Wang
Journal of the American Heart Association.2026;[Epub] CrossRef
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Ting-Chun Chen, Chih-Li Lin, Chien-Yin Kuo, Sing-Hua Tsou, Shun-Wen Hsiao, Chien-Ning Huang
Frontiers in Endocrinology.2026;[Epub] CrossRef
Modeling heart failure with preserved ejection fraction (HFpEF) likelihood among women with suspected coronary microvascular dysfunction (CMD)
Zev Allison, Sachini Ranasinghe, Jenna Maughan, Okezi Obrutu, Galen Cook-Wiens, Ana Iribarren, Alan Kwan, Michael Nelson, Debiao Li, Martha Gulati, C. Noel Bairey Merz, Janet Wei
American Heart Journal Plus: Cardiology Research and Practice.2026; 71: 100925. CrossRef
Long-term outcomes of unselected patients undergoing coronary angiography according to the presence or absence of type II diabetes mellitus
Philipp Steinke, Tobias Schupp, Lasse Kuhn, Mohammad Abumayyaleh, Mohamed Ayoub, Kambis Mashayekhi, Thomas Bertsch, Niklas Ayasse, Mahboubeh Jannesari, Fabian Siegel, Daniel Dürschmied, Michael Behnes, Ibrahim Akin
Cardiovascular Revascularization Medicine.2025; 78: 73. CrossRef
Different Associations between Lipid Levels and Risk for Heart Failure according to Diabetes Progression
Seung-Hwan Lee, Kyu Na Lee, Jong-Chan Youn, Hun Sung Kim, Kyungdo Han, Mee Kyoung Kim
Diabetes & Metabolism Journal.2025; 49(1): 105. CrossRef
High mRNA Expression of 24 Dehydrocholesterol Reductase (DHCR24) in the Treatment of Doxorubicin-Induced Heart Failure in Rats
Rui Zhang, Siyuan Peng, Xuejuan Zhang, Zhengwei Huang, Xin Pan
International Journal of Molecular Sciences.2025; 26(1): 312. CrossRef
Effect of trimetazidine on left ventricular functions and cardiac biomarkers in diabetic patients with left ventricular diastolic dysfunction: a randomized controlled trial
Heba Serag, Lamia El Wakeel, Viola William, Mona Abdelsalam, Ahmed Abdelsalam, Rana Sayed
Scientific Reports.2025;[Epub] CrossRef
Diabète, inflammation et maladies cardiovasculaires : avancées thérapeutiques et rôle clé de la colchicine
Rémi Arnold, Nidal Jammoul, Quentin Delbaere, François Roubille
Médecine des Maladies Métaboliques.2025; 19(2): 153. CrossRef
Prognostic Impact of Gait Speed, Muscle Strength and Muscle Mass in Chronic Heart Failure—A Prospective Cohort Study
Vladimir Cejka, Hermann Riepl, Nora Schwegel, Ewald Kolesnik, David Zach, Viktoria Santner, Viktoria Höller, Natascha Schweighofer, Barbara Obermayer-Pietsch, Thomas Pieber, Caroline Morbach, Stefan Frantz, Andreas Zirlik, Dirk von Lewinski, Stefan Störk,
ESC Heart Failure.2025; 12(3): 2113. CrossRef
Sitagliptin, diabetes mellitus, and heart failure: an in-depth review of sitagliptin therapy and heart failure in patients with diabetes mellitus
Mohammadjavad Sotoudeheian, Seyed-Mohamad-Sadegh Mirahmadi, Pedram Salehi Darjani, Mohammad Moradi, Mohammad Pirhayati, Mohammad Sedigh Dakkali, Mehdi Taghizadeh, Reza Azarbad, Hamidreza Pazoki Toroudi
Diabetology International.2025; 16(2): 237. CrossRef
Vitamin D and Type 2 Diabetes Mellitus: Molecular Mechanisms and Clinical Implications—A Narrative Review
Héctor Fuentes-Barría, Raúl Aguilera-Eguía, Cherie Flores-Fernández, Lissé Angarita-Davila, Diana Rojas-Gómez, Miguel Alarcón-Rivera, Olga López-Soto, Juan Maureira-Sánchez
International Journal of Molecular Sciences.2025; 26(5): 2153. CrossRef
The Role of Resistin in Macrovascular and Microvascular Complications of Type 2 Diabetes
Africa Samantha Reynoso-Roa, Susan Andrea Gutiérrez-Rubio, Ezequiel Magallón-Gastélum, Trinidad García-Iglesias, Daniel Osmar Suárez-Rico, Teresa Arcelia García-Cobián
Life.2025; 15(4): 585. CrossRef
Type 2 diabetes increases the risk of mortality and cardiovascular events in ischemic HFmrEF patients: a retrospective cohort study
Zhican Liu, Hailong Hu, Jianping Zeng, Mingyan Jiang
Diabetology & Metabolic Syndrome.2025;[Epub] CrossRef
Research Progress on Metabolic Disorders Associated with Diabetic Cardiomyopathy
佳君丁
Advances in Clinical Medicine.2025; 15(04): 1504. CrossRef
The landscape of novel antidiabetic drugs in diabetic HFpEF: relevant mechanisms and clinical implications
Xiangling Duan, Xiaomeng Zhang, Bao Sun
Cardiovascular Diabetology.2025;[Epub] CrossRef
Molecular Insights into Oxidative-Stress-Mediated Cardiomyopathy and Potential Therapeutic Strategies
Zhenyu Xiong, Yuanpeng Liao, Zhaoshan Zhang, Zhengdong Wan, Sijia Liang, Jiawei Guo
Biomolecules.2025; 15(5): 670. CrossRef
Biomarkers of heart failure in patients with type 2 diabetes mellitus: clinical comparisons and impact of hypoglycemic therapy
I. V. Druk, S. S. Safronova, O. Yu. Korennova, O. I. Kanunnikova, A. S. Kazachenko
Transbaikalian Medical Bulletin.2025; (1): 154. CrossRef
Therapeutic effects of finerenone and exenatide on diabetes-induced heart failure: A combined approach targeting inflammation and oxidative stress
Ayşe Koçak, Emirhan Günek, Elif Aydın, Meliha Koldemir Gündüz, Güllü Kaymak
European Journal of Pharmacology.2025; 1002: 177826. CrossRef
Irisin Protects Against Diabetic Cardiomyopathy by Suppressing Ferroptosis
Hongmei Ye, Jing Guo, Xinyu Wang, Bixian Chen, Lei Hu, Boyu Liu, Rongjing Song, Yufei Feng, Xiaohong Zhang
Drug Development Research.2025;[Epub] CrossRef
Ferroptosis: A novel therapeutic target for diabetic cardiomyopathy
Gui-Zhi Li, Jia-Yin Liu, Hong Zhou
World Journal of Diabetes.2025;[Epub] CrossRef
Sodium-Glucose Cotransporter 2 (SGLT2) Inhibitors in Heart Failure With Preserved Ejection Fraction: A Systematic Review
Amir Saeed, Bilal Younas, Ali Rohan, Usman Haider, Asad Mukhtar, Marriam Nazir, Maryam .
Cureus.2025;[Epub] CrossRef
Identifying High-Risk Atrial Fibrillation in Diabetes: Evidence from Nomogram and Plasma Metabolomics Analysis
Qiushi Luo, Xiaozhu Ma, Shuai Mei, Qidamugai Wuyun, Li Zhou, Ziyang Cai, Yi Wen, Shitao Wang, Jiangtao Yan, Huaping Li, Jiahui Fan, Meiyan Dai
Biomedicines.2025; 13(7): 1557. CrossRef
Infarct-Limiting Efficacy of KATP Channel Activators and Nitric Oxide Donors under Conditions of Their Chronic Administration and Diet-Induced Metabolic Syndrome Conditions in Rats
N. V. Naryzhnaya, A. V. Mukhomedzyanov, M. Kilin, N. S. Voronkov, B. K. Kurbatov, L. N. Maslov
Bulletin of Experimental Biology and Medicine.2025; 179(1): 1. CrossRef
Global, regional, and national burden of heart failure and its risk factors between 1990 and 2021 and projections to 2050: an analysis of the global burden of disease study
Shaohua Yan, Peizhi Deng, Ke Chai, Shengfeng Wang, Kai Hu, Jiefu Yang, Hua Wang
European Heart Journal - Quality of Care and Clinical Outcomes.2025; 11(7): 1144. CrossRef
Association of Different Types of Diabetic Autonomic Neuropathy With Left Ventricular Diastolic Dysfunction in Patients With Type 2 Diabetes: A Cross‐Sectional Study
Ruixue Feng, Donge Yan, Mingxin Bai, Xingwu Ran, Dawei Chen, Chun Wang, Lihong Chen, Shuang Lin, Sen He, Yan Liu, Murong Wu, Zhiyi Lei, Yun Gao
Journal of Diabetes.2025;[Epub] CrossRef
Association of Epicardial Adipose Tissue with Novel Inflammation and Heart Failure Biomarkers in Type 2 Diabetes Patients: Effect of Metabolic Control
Pedro Gil-Millan, José Rives, David Viladés, Álvaro García-Osuna, Idoia Genua, Inka Miñambres, Margarita Grau-Agramunt, Ignasi Gich, Mercedes Camacho, Sonia Benitez, Josep Julve, José Luis Sánchez-Quesada, Antonio Pérez
Journal of Clinical Medicine.2025; 14(13): 4687. CrossRef
Association between triglyceride-glucose-body mass index and adverse prognosis in elderly patients with severe heart failure and type 2 diabetes: a retrospective study based on the MIMIC-IV database
Jing Cheng, Qi Cheng, Yingting Wu, Jiashun Yin, Fei He
Cardiovascular Diabetology.2025;[Epub] CrossRef
Diabetes and calcific aortic valve disease: controversy of clinical outcomes in diabetes after aortic valve replacement
Feng Liu, Haipeng Cai
Frontiers in Endocrinology.2025;[Epub] CrossRef
Prediction model of rehospitalization and mortality in heart failure patients with preserved and mildly reduced ejection fraction: the AD2NNER risk score
Flavia-Mihaela Stoiculescu, Diana-Ruxandra Hădăreanu, Călin-Dinu Hădăreanu, Ionuț Donoiu, Octavian Istrătoaie, Victor-Cornel Raicea, Cristina Florescu
Frontiers in Cardiovascular Medicine.2025;[Epub] CrossRef
Obesity and Clinical Outcomes of Acute Decompensated Heart Failure
Alviyatul Ainin Nuvus, Andrianto Andrianto, Sony Wibisono Mudjanarko
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga.2025; 16(1): 70. CrossRef
Machine learning-driven prediction of readmission risk in heart failure patients with diabetes: synergistic assessment of inflammatory and metabolic biomarkers
Yue Hu, Yunhong Zhang, Ping Han, Yanqing Pan, Juanjuan Liu, Yangni Li, Defeng Pan, Jingjing Ren
International Journal of Cardiology.2025; 441: 133743. CrossRef
Association between estimated glucose disposal rate and heart failure in patients with diabetes or prediabetes: a cross-sectional study
Xiangkun Wang, Liang Zheng, Feng Lu
BMC Public Health.2025;[Epub] CrossRef
The Impact of Different Antidiabetic Drugs on Fracture Risk in Patients With Type 2 Diabetes Mellitus: A Systematic Review and Network Meta-analysis of Randomized Controlled Trials With a Focus on SGLT2 Inhibitors
Bushra Admani, Fizza Zehra Raza, Fatima Siddiqui, Muhammad Talal Ashraf, Muhammad Khuzzaim Khan, Ifra Habib, Ayesha Usman, Bareeha Mansoor, Zaira Nadeem, Rana Jahanzeb Ghaffer, Muhammad Riyyan, Sawaira Sajid, Muhammad Hassan Ali Chania, Mahnoor Saleem, Sa
American Journal of Medicine Open.2025; 14: 100115. CrossRef
Association between Chinese visceral adiposity index and heart failure in diabetic patients
Shiwei Kang, Shuohua Chen, Zuxu Lin, Mengcan Zhang, Jierui Wang, Shaopeng Liu, Youxin Wang, Dandan Zhao, Yuntao Wu, Yun Li
Diabetes, Obesity and Metabolism.2025; 27(11): 6516. CrossRef
Diabetic cardiomyopathy: merely a complication or a distinct understudied disease?
B. U. Mardanov, M. N. Mamedov
Rational Pharmacotherapy in Cardiology.2025; 21(3): 298. CrossRef
Gut Microbiota‐Derived Metabolites Orchestrate Metabolic Reprogramming in Diabetic Cardiomyopathy: Mechanisms and Therapeutic Frontiers
Jing‐yu Jin, Xin‐yu Yang, Ru Feng, Meng‐liang Ye, Hui Xu, Jing‐yue Wang, Jia‐chun Hu, Heng‐tong Zuo, Jin‐yue Lu, Jian‐ye Song, Yi Zhao, Yan Wang, Qian Tong
The FASEB Journal.2025;[Epub] CrossRef
Redefiniendo la atención primaria: recomendaciones de CARABELA-AP para el manejo de enfermedades crónicas prevalentes
J. Polo, P. Rodríguez, I. Mediavilla, A. Pérez, L. Regadera, E. Fitas, C. Moreno, A. Prado, A. Izarra, R.M. Micó-Pérez
Medicina de Familia. SEMERGEN.2025; 51(8): 102586. CrossRef
Chinese visceral adiposity index predicts all-cause mortality in patients with type 2 diabetes, heart failure, and chronic kidney disease: a retrospective cohort study
Xiang Zhao, Dan Zhang, Bing Zhu, Yuanhao Yao, Lingxiao Geng, Xiang Ma, Zhenyan Fu, Yitong Ma
BMC Research Notes.2025;[Epub] CrossRef
HFpEF as the predominant and underrecognized heart failure phenotype in type 2 diabetes: evidence from the DIABET-IC study
P. Gil-Millan, JA. Gimeno-Orna, L. Rodriguez-Padial, J. Muniz, V. Barrios, M. Anguita, A. Perez
Cardiovascular Diabetology.2025;[Epub] CrossRef
Coronary heart disease and type 2 diabetes metabolomic signatures in the Middle East
Mohamed Elshrif, Keivin Isufaj, Ayman El-Menyar, Ehsan Ullah, Alka Beotra, Mohammed Al-Maadheed, Vidya Mohamed-Ali, Mohamad Saad, Jassim Al Suwaidi
Frontiers in Endocrinology.2025;[Epub] CrossRef
Screening Natriuretic Peptide Levels Predicts Heart Failure and Death in Individuals With Type 1 and Type 2 Diabetes Without Known Heart Failure
Rodica Pop-Busui, Enrico Repetto, Jason Baron, Dagmar Schumacher, Muthiah Vaduganathan, Ambarish Pandey
Diabetes Care.2025; 48(12): 2145. CrossRef
α-Linolenic Acid Alleviates Diabetic Cardiomyopathy by Activating AMPK-STAT3 Pathway to Inhibit Ferritinophagy and Enhance SLC7A11-GPX4 Antioxidant Axis
Ziqian Zhang, Xue Bai, Qian Du, Jianhong Yang
Molecules.2025; 31(1): 79. CrossRef
Efficacy of Platelet-Rich Plasma in the Treatment of Diabetic Foot Ulcers: A Systematic Review and Meta-Analysis
Yundong Peng, JiePing Wang, Xinyao Liu, Yanqing Zhou, Shaohui Jia, Jinrong Xu, Cheng Zheng
Annals of Vascular Surgery.2024; 98: 365. CrossRef
Diabetic Cardiomyopathy: 2023 Update by the International Multidisciplinary Board of Experts
Ashot Avagimyan, Federica Fogacci, Nana Pogosova, Lev Kakrurskiy, Eugenia Kogan, Olga Urazova, Zhanna Kobalava, Liudmila Mikhaleva, Rositsa Vandysheva, Gioeva Zarina, Artem Trofimenko, Grizelda Navasardyan, Lusine Mkrtchyan, Mattia Galli, Zinaida Jndoyan,
Current Problems in Cardiology.2024; 49(1): 102052. CrossRef
Emerging Biomarkers in the Laboratory and in Practice: A Novel Approach to Diagnosing Heart Failure in Diabetes
Rachel E. Aaron, Tiffany Tian, G. Alexander Fleming, David B. Sacks, James L. Januzzi, MD FACC, Rodica Pop-Busui, Ibrahim A. Hashim, Alan H. B. Wu, Ambarish Pandey, David C. Klonoff
Journal of Diabetes Science and Technology.2024; 18(3): 733. CrossRef
Research Progress on the Relationship between HbA_1c and Diabetes Complicated with Chronic Heart Failure
·依沙迪达尔
Advances in Clinical Medicine.2024; 14(01): 1117. CrossRef
Association Between Use of Sodium-Glucose Cotransporter-2 Inhibitors or Angiotensin Receptor-Neprilysin Inhibitor and the Risk of Atherosclerotic Cardiovascular Disease With Coexisting Diabetes and Heart Failure
Ya-Wen Lin, Chun-Hsiang Lin, Cheng-Li Lin, Che-Huei Lin, Ming-Hung Lin
Journal of Cardiovascular Pharmacology and Therapeutics.2024;[Epub] CrossRef
The Role of Epicardial Adipose Tissue in Acute Coronary Syndromes, Post-Infarct Remodeling and Cardiac Regeneration
Kamil Krauz, Marcel Kempiński, Paweł Jańczak, Karol Momot, Maciej Zarębiński, Izabela Poprawa, Małgorzata Wojciechowska
International Journal of Molecular Sciences.2024; 25(7): 3583. CrossRef
Molecular mechanisms of metabolic dysregulation in diabetic cardiomyopathy
Yue Zeng, Yilang Li, Wenyue Jiang, Ning Hou
Frontiers in Cardiovascular Medicine.2024;[Epub] CrossRef
Association between nonalcoholic fatty liver disease and left ventricular diastolic dysfunction: A 7-year retrospective cohort study of 3,380 adults using serial echocardiography
Gyuri Kim, Tae Yang Yu, Jae Hwan Jee, Ji Cheol Bae, Mira Kang, Jae Hyeon Kim
Diabetes & Metabolism.2024; 50(3): 101534. CrossRef
SGLT2 Inhibitors in the Cardiovascular Disease
Jin Joo Park
The Journal of Korean Diabetes.2024; 25(1): 26. CrossRef
Metabolic Alteration Bridging the Prediabetic State and Colorectal Cancer
Antonino Colloca, Isabella Donisi, Camilla Anastasio, Maria Luisa Balestrieri, Nunzia D’Onofrio
Cells.2024; 13(8): 663. CrossRef
Inflammation in diabetes complications: molecular mechanisms and therapeutic interventions
Lu Zhao, Haoran Hu, Lin Zhang, Zheting Liu, Yunchao Huang, Qian Liu, Liang Jin, Meifei Zhu, Ling Zhang
MedComm.2024;[Epub] CrossRef
Methods to predict heart failure in diabetes patients
Alexander E. Berezin, Tetiana A Berezina, Uta C. Hoppe, Michael Lichtenauer, Alexander A. Berezin
Expert Review of Endocrinology & Metabolism.2024; 19(3): 241. CrossRef
Research advances on molecular mechanism and natural product therapy of iron metabolism in heart failure
Tianqing Zhang, Li Luo, Qi He, Sijie Xiao, Yuwei Li, Junpeng Chen, Tao Qin, Zhenni Xiao, Qingliang Ge
European Journal of Medical Research.2024;[Epub] CrossRef
The latest emerging drugs for the treatment of diabetic cardiomyopathy
Minghao Li, Lin Liu, Chunyu Zhang, Li Deng, Yi Zhong, Bin Liao, Xiuying Li, Ying Wan, Jian Feng
Expert Opinion on Pharmacotherapy.2024; 25(6): 641. CrossRef
Prevalencia de insuficiencia cardiaca diagnosticada en pacientes diabéticos en el ámbito de la atención primaria. ¿Debemos mejorar el cribado?
Manuel Sánchez Molla, Juan Manuel Zazo Menargues, Inmaculada Candela Garcia
Atención Primaria.2024; 56(7): 102952. CrossRef
Targeting autophagy in diabetic cardiomyopathy: From molecular mechanisms to pharmacotherapy
Jie Li, Yingying Xie, Shuwen Zheng, Haoming He, Zhe Wang, Xuexi Li, Siqi Jiao, Dong Liu, Furong Yang, Hailing Zhao, Ping Li, Yihong Sun
Biomedicine & Pharmacotherapy.2024; 175: 116790. CrossRef
Interleukin 1β receptor blocker (Anakinra) and regenerative stem cell therapy: two novel approaches effectively ameliorating diabetic cardiomyopathy
Lamiaa Mohamed Mahmoud, Aya Aly Ashraf Abdel Mageed, Jackline Moawad Saadallah, Mira Farouk Youssef, Liala Ahmed Rashed, Hania Ibrahim Ammar
Naunyn-Schmiedeberg's Archives of Pharmacology.2024; 397(10): 8023. CrossRef
Heart failure phenotypes and clinical and laboratory features of patients with type 2 diabetes in inpatient endocrinology and cardiology practice
T. Yu. Demidova, M. Ya. Izmaylova
Meditsinskiy sovet = Medical Council.2024; (6): 81. CrossRef
Potential molecular and cellular mechanisms of the effects of cuproptosis-related genes in the cardiomyocytes of patients with diabetic heart failure: a bioinformatics analysis
Jinhao Chen, Xu Yang, Weiwen Li, Ying Lin, Run Lin, Xianzhen Cai, Baoxin Yan, Bin Xie, Jilin Li
Frontiers in Endocrinology.2024;[Epub] CrossRef
The Interplay of Comorbidities in Chronic Heart Failure: Challenges and Solutions
Shashipriya Agress, Jannat S. Sheikh, Aida A. Perez Ramos, Durlav Kashyap, Soha Razmjouei, Joy Kumar, Mankaranvir Singh, Muhammad Ali Lak, Ali Osman, Muhammad Zia ul Haq
Current Cardiology Reviews.2024;[Epub] CrossRef
Prescripción de antihipertensivos en personas con diabetes tipo 2 en Andalucía y recomendaciones SEH-LELHA 2022: evaluación del coste y uso
D. Martín-Enguix, J.C. Aguirre Rodríguez, M. Guisasola Cárdenas, M.N. Generoso Torres, A. Hidalgo Rodríguez, M. Sánchez Cambronero, A. González Bravo
Hipertensión y Riesgo Vascular.2024; 41(4): 226. CrossRef
Detecting heart stress using NT-proBNP in patients with type 2 diabetes mellitus and hypertension or high-normal blood pressure: a cross-sectional multicentric study
Matteo Landolfo, Francesco Spannella, Federico Giulietti, Beatrice Ortensi, Lucia Stella, Maria A. Carlucci, Roberta Galeazzi, Federica Turchi, Maria P. Luconi, Roberto Zampa, Sofia Cecchi, Elena Tortato, Massimiliano Petrelli, Riccardo Sarzani
Cardiovascular Diabetology.2024;[Epub] CrossRef
The mechanism and promising therapeutic strategy of diabetic cardiomyopathy dysfunctions: Focus on pyroptosis
Xiao-fei Geng, Wen-yu Shang, Zhong-wen Qi, Chi Zhang, Wen-xiu Li, Zhi-peng Yan, Xin-biao Fan, Jun-ping Zhang
Journal of Diabetes and its Complications.2024; 38(10): 108848. CrossRef
The effects of resistance training on cardiovascular factors and anti-inflammation in diabetic rats
Jin Yoo, Jinsu Hwang, Jiyun Choi, Mahesh Ramalingam, Haewon Jeong, Sujeong Jang, Han-Seong Jeong, Daeyeol Kim
Heliyon.2024; 10(17): e37081. CrossRef
The association of glycaemic risk factors and diabetes duration with risk of heart failure in people with type 2 diabetes: A systematic review and meta‐analysis
Mahtab Tabesh, Julian W. Sacre, Kanika Mehta, Lei Chen, Seyeddeh Forough Sajjadi, Dianna J. Magliano, Jonathan E. Shaw
Diabetes, Obesity and Metabolism.2024; 26(12): 5690. CrossRef
Metabolomic Profiling Reveals That Exercise Lowers Biomarkers of Cardiac Dysfunction in Rats with Type 2 Diabetes
Tutu Wang, Miaomiao Ning, Yurou Mo, Xinyu Tian, Yu Fu, Ismail Laher, Shunchang Li
Antioxidants.2024; 13(10): 1167. CrossRef
Repair and regeneration: ferroptosis in the process of remodeling and fibrosis in impaired organs
Jiali Yin, Xinjun Xu, Ying Guo, Caiyu Sun, Yujuan Yang, Huifang Liu, Pengyi Yu, Tong Wu, Xicheng Song
Cell Death Discovery.2024;[Epub] CrossRef
Management of a Dual Low Sodium and Diabetic Diet by Patient-Caregiver Dyads: A Qualitative Descriptive Study
Leigh Anne DeNotto, Misook L. Chung, Kaitlin Voigts Key, Gia Mudd-Martin
The Science of Diabetes Self-Management and Care.2024; 50(6): 520. CrossRef
The triglyceride-glucose index, ventricular arrhythmias and major cardiovascular events in patients at high risk of sudden cardiac death
Yuan Gao, Zhuxin Zhang, Mengxing Cai, Zhongli Chen, Sijin Wu, Jiandu Yang, Xiaogang Guo, Ruohan Chen, Yan Dai, Shu Zhang, Xiaoyao Li, Qi Sun, Keping Chen
Cardiovascular Diabetology.2024;[Epub] CrossRef
Sodium-glucose cotransporter 2 inhibitors in cardiocerebrovascular disease
Jin Joo Park
Cardiovascular Prevention and Pharmacotherapy.2024; 6(4): 103. CrossRef
Insulin Resistance–Nutritional Index: A Simple Index and Potential Predictor of Mortality Risk in Patients with Chronic Heart Failure and Type 2 Diabetes
You Zhou, Yingli Xie, Jingjing Dong, Kunlun He, Hebin Che
Diabetes, Metabolic Syndrome and Obesity.2024; Volume 17: 4177. CrossRef
The prognostic value of cartilage intermediate layer protein 1 (CILP1) in patients with diabetic cardiomyopathy
Li Xiang, Xiang Liu, Xuehua Jiao, Zhenguo Qiao
BMC Cardiovascular Disorders.2024;[Epub] CrossRef
Impact of DPP-4 Inhibitors in Patients with Diabetes Mellitus and Heart Failure: An In-Depth Review
Francisco Epelde
Medicina.2024; 60(12): 1986. CrossRef
Peripheral arterial atherosclerosis and heart failure: state of the art review
V. V. Genkel, O. V. Latysheva, S. V. Ershov, E. V. Lebedev, A. S. Kuznetsova, A. O. Salashenko, I. I. Shaposhnik
South Russian Journal of Therapeutic Practice.2024; 5(4): 15. CrossRef
Diabetes Mellitus and Cardiovascular Disease: Exploring Epidemiology, Pathophysiology, and Treatment Strategies
Nawfal Hasan Siam, Nayla Nuren Snigdha, Noushin Tabasumma, Irin Parvin
Reviews in Cardiovascular Medicine.2024;[Epub] CrossRef
Effects of multidisciplinary collaborative treatment in patients with chronic heart failure
Wei Song
American Journal of Translational Research.2024; 16(12): 7803. CrossRef
Association between Dapagliflozin, Cardiac Biomarkers and Cardiac Remodeling in Patients with Diabetes Mellitus and Heart Failure
Andrew Xanthopoulos, Nikolaos Katsiadas, Spyridon Skoularigkis, Dimitrios E. Magouliotis, Niki Skopeliti, Sotirios Patsilinakos, Alexandros Briasoulis, Filippos Triposkiadis, John Skoularigis
Life.2023; 13(8): 1778. CrossRef
Empagliflozin for Patients with Heart Failure and Type 2 Diabetes Mellitus: Clinical Evidence in Comparison with Other Sodium-Glucose Co-transporter-2 Inhibitors and Potential Mechanism
Bo Liang, Rui Li, Peng Zhang, Ning Gu
Journal of Cardiovascular Translational Research.2023; 16(2): 327. CrossRef
Causes and Determinants of Heart Failure Readmissions Post Transcutaneous Aortic Valve Replacement: A Systematic Review and Meta-Analysis
Farah Yasmin, Muhammad Aamir, Abdul Moeed, Kinza Iqbal, Aymen Iqbal, Muhammad Sohaib Asghar, Waqas Ullah, Indranee Rajapreyar, Yevgeniy Brailovsky
Current Problems in Cardiology.2023; 48(1): 101428. CrossRef
Discussion of a study on the role of EMS in prognosis of elderly patients with AHF
Qingzhuo Yang, Hui Wu, Di Liu, Yunzhao Li, Gang Zhou, Dong Zhang, Yanfang Liu, Yi Li
International Journal of Cardiology.2023; 377: 91. CrossRef
The management correlation between metabolic index, cardiovascular health, and diabetes combined with cardiovascular disease
Yi Zhang, Chao Liu, Yijing Xu, Yanlei Wang, Fang Dai, Honglin Hu, Tian Jiang, Yunxia Lu, Qiu Zhang
Frontiers in Endocrinology.2023;[Epub] CrossRef
Evaluation and Management of Patients With Diabetes and Heart Failure: A Korean Diabetes Association and Korean Society of Heart Failure Consensus Statement
Kyu-Sun Lee, Junghyun Noh, Seong-Mi Park, Kyung Mook Choi, Seok-Min Kang, Kyu-Chang Won, Hyun-Jai Cho, Min Kyong Moon
International Journal of Heart Failure.2023; 5(1): 1. CrossRef
Evaluation and Management of Patients with Diabetes and Heart Failure: A Korean Diabetes Association and Korean Society of Heart Failure Consensus Statement
Kyu-Sun Lee, Junghyun Noh, Seong-Mi Park, Kyung Mook Choi, Seok-Min Kang, Kyu-Chang Won, Hyun-Jai Cho, Min Kyong Moon
Diabetes & Metabolism Journal.2023; 47(1): 10. CrossRef
Lower Circulating Cell-Free Mitochondrial DNA Is Associated with Heart Failure in Type 2 Diabetes Mellitus Patients
Tetiana Berezina, Mykola Kopytsya, Olga Petyunina, Alexander Berezin, Zeljko Obradovic, Lukas Schmidbauer, Michael Lichtenauer, Alexander Berezin
Cardiogenetics.2023; 13(1): 15. CrossRef
Novel model predicts diastolic cardiac dysfunction in type 2 diabetes
Mingyu Hao, Xiaohong Huang, Xueting Liu, Xiaokang Fang, Haiyan Li, Lingbo Lv, Liming Zhou, Tiecheng Guo, Dewen Yan
Annals of Medicine.2023; 55(1): 766. CrossRef
Cholinergic drugs reduce metabolic inflammation and diabetic myocardial injury by regulating the gut bacterial component lipopolysaccharide‐induced ERK/Egr‐1 pathway
Qing Wu, Ming Zhao, Dongling Li, Xi He, Weijin Zang
The FASEB Journal.2023;[Epub] CrossRef
Ferroptosis: roles and molecular mechanisms in diabetic cardiomyopathy
Yangting Zhao, Binjing Pan, Xiaoyu Lv, Chongyang Chen, Kai Li, Yawen Wang, Jingfang Liu
Frontiers in Endocrinology.2023;[Epub] CrossRef
Cardiorenal syndrome and diabetes: an evil pairing
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Journal of Clinical Medicine.2023; 12(13): 4458. CrossRef
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M. N. Zatsepina, F. O. Ushanova, T. L. Bogacheva
FOCUS. Endocrinology.2023; 4(2): 42. CrossRef
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Biomarkers in Medicine.2023; 17(10): 487. CrossRef
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Life Sciences.2022; 289: 120193. CrossRef
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Diabetes Care.2022; 45(7): 1670. CrossRef
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Mayila Abudoukelimu, Bayinsilema Ba, Yan Kai Guo, Jie Xu
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Diabetes Research and Clinical Practice.2022; 192: 110083. CrossRef
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Diabetes & Metabolism Journal.2022; 46(5): 667. CrossRef
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Ruxin Wang, Juan Wu, Haowen Ye, Xiaofang Zhang, Lihong Wang
Medicina.2022; 58(10): 1473. CrossRef
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Jure Bosanac, Lara Straus, Marko Novaković, Daniel Košuta, Mojca Božič Mijovski, Jerneja Tasič, Borut Jug, Azizah Ugusman
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Diabetes Care.2022; 45(12): 2999. CrossRef
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Heart Failure Reviews.2021; 28(3): 667. CrossRef

Original Article

Basic Research
Role of Autophagy in Granulocyte-Colony Stimulating Factor Induced Anti-Apoptotic Effects in Diabetic Cardiomyopathy: Guang-Yin Shen, Jeong-Hun Shin, Yi-Sun Song, Hyun-Woo Joo, In-Hwa Park, Jin-Hee Seong, Na-Kyoung Shin, A-Hyeon Lee, Young Jong Cho, Yonggu Lee, Young-Hyo Lim, Hyuck Kim, Kyung-Soo Kim; Diabetes Metab J. 2021;45(4):594-605. Published online February 26, 2021; DOI: https://doi.org/10.4093/dmj.2020.0049

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Background
We previously, reported that granulocyte-colony stimulating factor (G-CSF) reduces cardiomyocyte apoptosis in diabetic cardiomyopathy. However, the underlying mechanisms are not yet fully understood. Therefore, we investigated whether the mechanisms underlying of the anti-apoptotic effects of G-CSF were associated with autophagy using a rat model of diabetic cardiomyopathy.
Methods
Diabetic cardiomyopathy was induced in rats through a high-fat diet combined with low-dose streptozotocin and the rats were then treated with G-CSF for 5 days. Rat H9c2 cardiac cells were cultured under high glucose conditions as an in vitro model of diabetic cardiomyopathy. The extent of apoptosis and protein levels related to autophagy (Beclin-1, microtubule-binding protein light chain 3 [LC3]-II/LC3-I ratio, and P62) were determined for both models. Autophagy determination was performed using an Autophagy Detection kit.
Results
G-CSF significantly reduced cardiomyocyte apoptosis in the diabetic myocardium in vivo and led to an increase in Beclin-1 level and the LC3-II/LC3-I ratio, and decreased P62 level. Similarly, G-CSF suppressed apoptosis, increased Beclin-1 level and LC3-II/LC3-I ratio, and decreased P62 level in high glucose-induced H9c2 cardiac cells in vitro. These effects of G-CSF were abrogated by 3-methyladenine, an autophagy inhibitor. In addition, G-CSF significantly increased autophagic flux in vitro.
Conclusion
Our results suggest that the anti-apoptotic effect of G-CSF might be significantly associated with the up-regulation of autophagy in diabetic cardiomyopathy.

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Review

Basic Research
Mitochondrial Mechanisms in Diabetic Cardiomyopathy: Johannes Gollmer, Andreas Zirlik, Heiko Bugger; Diabetes Metab J. 2020;44(1):33-53. Published online February 21, 2020; DOI: https://doi.org/10.4093/dmj.2019.0185

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Mitochondrial medicine is increasingly discussed as a promising therapeutic approach, given that mitochondrial defects are thought to contribute to many prevalent diseases and their complications. In individuals with diabetes mellitus (DM), defects in mitochondrial structure and function occur in many organs throughout the body, contributing both to the pathogenesis of DM and complications of DM. Diabetic cardiomyopathy (DbCM) is increasingly recognized as an underlying cause of increased heart failure in DM, and several mitochondrial mechanisms have been proposed to contribute to the development of DbCM. Well established mechanisms include myocardial energy depletion due to impaired adenosine triphosphate (ATP) synthesis and mitochondrial uncoupling, and increased mitochondrial oxidative stress. A variety of upstream mechanisms of impaired ATP regeneration and increased mitochondrial reactive oxygen species have been proposed, and recent studies now also suggest alterations in mitochondrial dynamics and autophagy, impaired mitochondrial Ca²⁺ uptake, decreased cardiac adiponectin action, increased O-GlcNAcylation, and impaired activity of sirtuins to contribute to mitochondrial defects in DbCM, among others. In the current review, we present and discuss the evidence that underlies both established and recently proposed mechanisms that are thought to contribute to mitochondrial dysfunction in DbCM.

Citations

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Suin Park, Jehee Jang, Young-Won Kim, Jae-Hong Ko, Sungguan Hong, Sung Hoon Lee, Kei Hayashida, Ki-Woon Kang
Korean Circulation Journal.2027;[Epub] CrossRef
Long Noncoding RNA H19 Overexpression Inhibits High Glucose-Induced Oxidative Stress of Cardiomyocytes by Targeting MicroRNA-138-5p/MCU Axis: Implications for Diabetic Cardiomyopathy
Xuelin Liu, Qian Zhang, Yuemei Zhang, Jianting Dong, Ruilin Wang, Qi Zhang, Yongqing Chen
Biochemical Genetics.2026; 64(4): 4808. CrossRef
Comparison of diagnostic criteria for fatty liver disease in assessing cardiac dysfunction: a cross-sectional study
Yun Kyung Cho, Myung Jin Kim, Eun Hee Kim, Min Jung Lee, Hyo-Jung Nam, Woo Je Lee, Hong-Kyu Kim, Chang Hee Jung
Hepatology International.2026; 20(1): 81. CrossRef
SGLT2 inhibitors: Do they have antiarrhythmic properties?
Ricardo Caballero, Juan Tamargo, Eva Delpón
Pharmacology & Therapeutics.2026; 279: 108973. CrossRef
Effects of exercise training on oxidative phosphorylation-related genes in a diabetic heart via microarray analysis
Iqbal Ali Shah, Shahid Ishaq, Shin-Da Lee, Bor-Tsang Wu
BMC Cardiovascular Disorders.2026;[Epub] CrossRef
Mitochondrial dysfunction in diabetic cardiomyopathy: a review of pathogenic mechanisms and therapeutic strategies
Yulian Huang, Qiao Ma, Wei Wang, Shanjun Huang, Jianqiang Zhao
Frontiers in Cardiovascular Medicine.2026;[Epub] CrossRef
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O. I. Pisarenko, I. M. Studneva
Kardiologiia.2026; 66(2): 85. CrossRef
GULP1 protects against diabetic cardiomyopathy through IKIP/NF-κB-dependent improvement of mitochondrial function
Meng-Yuan Jiang, Xiao-Hua Zhang, Huan-Le Zhang, Yue Hou, Mei-Ying Qi, Yi-Xuan Zuo, Chuang Sun, Xin-Chun Dai, Ning-Ning Zhang, Tian-Qi Chen, Yan Zhang, Wan-Rong Man, Cong-Ye Li, Jie Lin, Wen Ge, Li-Yu Yang, Xing Qin, Dong-Dong Sun
Cardiovascular Diabetology.2026;[Epub] CrossRef
Intermittent Fasting Restores Cardiac Lipid Homeostasis in Diabetic Cardiomyopathy in Association With Akkermansia Muciniphila and 1‐methyl‐L‐histidine
Kaiyuan Jiang, Fen Xiong, Yiwen Peng, Lingfei Meng, Xinran Wang, Yingruo Xu, Tian Tang, Hongchang Gao
Advanced Science.2026;[Epub] CrossRef
Lipid Droplets as Metabolic–Epigenetic Signaling Hubs: Interplay Between Phase Separation, Cellular Adaptation, and Disease
Bin Ai, Xiaodan Chong
Cells.2026; 15(14): 1272. CrossRef
Elucidating the therapeutic potential of natural products in alleviating diabetic cardiomyopathy: contemporary progress and forthcoming opportunities
Daozheng Fang, Judyta Cielecka-Piontek, Renald Blundell, Zhangfeng Zhong, Jihang Chen
Phytomedicine.2026; 161: 158707. CrossRef
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Noor Karim, Miao Qin, Rachana Eshwaran, Feng Shao, Santosh Lomada, Merve Keles, Yixin Wang, Felix A. Trogisch, Uwe Schlattner, Joerg Heineke, Thomas Wieland, Yuxi Feng
International Journal of Molecular Sciences.2026; 27(17): 7518. CrossRef
SGLT2 inhibitors as modulators of mitochondrial ion transport and ER-mitochondria cross talk in diabetic cardiomyopathy
Jessa Flores, Maria Victoria Faith Garcia, Prycelline Abedejos, Jed Allyn Hernandez, Trong Kha Pham, Hyoung Kyu Kim, Jubert Marquez, Jin Han
American Journal of Physiology-Cell Physiology.2026; 331(3): C722. CrossRef
Binaphthoquinone attenuates myofibroblast transition of human ventricular cardiac fibroblasts in vitro via mitochondrial modulation under diabetic conditions
Chang Shin Yoon, Jeong Rim Ko, Nammi Park, Se Hwan Park, Hyoung Kyu Kim, Jin Han
The Korean Journal of Physiology & Pharmacology.2026; 30(5): 407. CrossRef
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Xiangyun Meng, Shuming Guo, Hui Lin, Ruchao Li, Wei Peng, Lingang Sun, Xiaowei Shi, Lixia Yang
Frontiers in Cell and Developmental Biology.2026;[Epub] CrossRef
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Frontiers in Endocrinology.2026;[Epub] CrossRef
Mitochondrial quality control: Biochemical mechanism of cardiovascular disease
Francesca Inferrera, Ylenia Marino, Tiziana Genovese, Salvatore Cuzzocrea, Roberta Fusco, Rosanna Di Paola
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research.2025; 1872(3): 119906. CrossRef
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Jie-Eun Lee, Byung Gyu Kim, Jong Chul Won
Journal of Lipid and Atherosclerosis.2025; 14(1): 46. CrossRef
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Jie-Eun Lee, Byung Gyu Kim, Jong Chul Won
Journal of Lipid and Atherosclerosis.2025; 14(1): 54. CrossRef
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Feng Zhang, Zhuqing Li, Yanxin Wang, Chao Li, Chengzhi Lu
Cardiovascular Innovations and Applications.2025;[Epub] CrossRef
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Humin Chen, Liang Guo
International Journal of Molecular Sciences.2025; 26(4): 1465. CrossRef
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Daiqi Liu, Lu Zhou, Beizheng Xu, Gary Tse, Qingmiao Shao, Tong Liu
Cellular Signalling.2025; 130: 111663. CrossRef
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Franklyn Nonso Iheagwam, Amarachi Joy Joseph, Eniola Deborah Adedoyin, Olawumi Toyin Iheagwam, Samuel Akpoyowvare Ejoh
Pathophysiology.2025; 32(1): 9. CrossRef
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Runyuan Li, Xiaoyu Yan, Yuanxin Zhao, Huan Liu, Jian Wang, Yuan Yuan, Qianyuan Li, Jing Su
Antioxidants.2025; 14(3): 267. CrossRef
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Quanrun He, Xinhang Li, Haimeng Li, Aditya Tan, Yunlin Chi, Daozheng Fang, Xinyue Li, Zhihao Liu, Qixiang Shang, Yong Zhu, Judyta Cielecka-Piontek, Jihang Chen
Journal of Agricultural and Food Chemistry.2025; 73(11): 6293. CrossRef
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Biochemical and Biophysical Research Communications.2025; 761: 151720. CrossRef
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Pan Wang, Ziling Wang, Xinyuan Jin, Mengdi Zhang, Mengfan Shen, Dan Li
Antioxidants.2025; 14(5): 603. CrossRef
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Journal of Cardiovascular Translational Research.2025; 18(4): 800. CrossRef
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Journal of Molecular and Cellular Cardiology Plus.2025; 13: 100469. CrossRef
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Nutrients.2025; 17(13): 2209. CrossRef
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David Chen, Andrew Sindone, Michael L.H. Huang, Karlheinz Peter, Alicia J. Jenkins
Journal of Molecular and Cellular Cardiology.2025; 206: 55. CrossRef
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Frontiers in Endocrinology.2025;[Epub] CrossRef
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European Heart Journal - Cardiovascular Pharmacotherapy.2025; 11(7): 620. CrossRef
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XiaoPei Wu, Ji Yang, JunDong He
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International Journal of Molecular Sciences.2025; 26(17): 8475. CrossRef
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Current Issues in Molecular Biology.2025; 47(11): 886. CrossRef
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Archives of Physiology and Biochemistry.2024; 130(1): 13. CrossRef
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Chennian Xu, Lin Xia, Dengyue Xu, Yang Liu, Ping Jin, Mengen Zhai, Yu Mao, Yiwei Wang, Anguo Wen, Jian Yang, Lifang Yang
Journal of Cellular and Molecular Medicine.2024;[Epub] CrossRef
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Jiabing Zhan, Kunying Jin, Rong Xie, Jiahui Fan, Yuyan Tang, Chen Chen, Huaping Li, Dao Wen Wang
Circulation.2024; 149(14): 1102. CrossRef
Pathophysiological aspects of morphological changes in the structure of atrioventricular valves leafl ets in diabetes mellitus
V. V. Krylov, M. R. Ragimov, I. V. Misnikova
Clinical Medicine (Russian Journal).2024; 102(2): 109. CrossRef
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Jun-yi Zhu, Joyce van de Leemput, Zhe Han
Disease Models & Mechanisms.2024;[Epub] CrossRef
SGLT2 inhibitors: from glucose-lowering to cardiovascular benefits
Alberto Preda, Fabrizio Montecucco, Federico Carbone, Giovanni G Camici, Thomas F Lüscher, Simon Kraler, Luca Liberale
Cardiovascular Research.2024; 120(5): 443. CrossRef
Glucagon-like peptide-1 receptor agonists and sodium-glucose cotransporter 2 inhibitors, anti-diabetic drugs in heart failure and cognitive impairment: potential mechanisms of the protective effects
Maria Antonietta Riemma, Elena Mele, Maria Donniacuo, Marialucia Telesca, Gabriella Bellocchio, Giuseppe Castaldo, Francesco Rossi, Antonella De Angelis, Donato Cappetta, Konrad Urbanek, Liberato Berrino
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Journal of Translational Medicine.2024;[Epub] CrossRef
Lysophosphatidylcholine trigger myocardial injury in diabetic cardiomyopathy via the TLR4/ZNF480/AP-1/NF-kB pathway
Nannan Liu, Yang Chen, Tian An, Siyu Tao, Bohan Lv, Jinfang Dou, Ruxue Deng, Xianjie Zhen, Yuelin Zhang, Caizhong Lu, Zhongsheng Chang, Guangjian Jiang
Heliyon.2024; 10(13): e33601. CrossRef
Improvement of Cardiac Function and Subcellular Defects Due to Chronic Diabetes upon Treatment with Sarpogrelate
Paramjit S. Tappia, Vijayan Elimban, Anureet K. Shah, Ramesh K. Goyal, Naranjan S. Dhalla
Journal of Cardiovascular Development and Disease.2024; 11(7): 215. CrossRef
Progress of Mitochondrial Kinetics in Ejection Fraction Preserving Heart Failure
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Advances in Clinical Medicine.2024; 14(07): 945. CrossRef
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Silvia Giardinelli, Giovanni Meliota, Donatella Mentino, Gabriele D’Amato, Maria Felicia Faienza
International Journal of Molecular Sciences.2024; 25(15): 8280. CrossRef
Exendin-4 exhibits cardioprotective effects against high glucose-induced mitochondrial abnormalities: Potential role of GLP-1 receptor and mTOR signaling
Warisara Parichatikanond, Sudhir Pandey, Supachoke Mangmool
Biochemical Pharmacology.2024; 229: 116552. CrossRef
Therapeutic potential of finerenone for diabetic cardiomyopathy: focus on the mechanisms
Jing Wang, Haojie Xue, Jinyu He, Li Deng, Julong Tian, Yang Jiang, Jian Feng
Diabetology & Metabolic Syndrome.2024;[Epub] CrossRef
Targeting DUSP26 to drive cardiac mitochondrial dynamics via FAK-ERK signaling in diabetic cardiomyopathy
Chong Liu, Xiangli Xu, Guiming Sun, Chengchao Song, Shuangquan Jiang, Ping Sun, Jiawei Tian
Free Radical Biology and Medicine.2024; 225: 856. CrossRef
Effects of Exercise Training on Cardiac Mitochondrial Functions in Diabetic Heart: A Systematic Review
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International Journal of Molecular Sciences.2024; 26(1): 8. CrossRef
Cellular interplay between cardiomyocytes and non-myocytes in diabetic cardiomyopathy
Ren Jie Phang, Rebecca H Ritchie, Derek J Hausenloy, Jarmon G Lees, Shiang Y Lim
Cardiovascular Research.2023; 119(3): 668. CrossRef
Mitochondrial miRNA as epigenomic signatures: Visualizing aging-associated heart diseases through a new lens
Jasvinder Singh Bhatti, Naina Khullar, Rajesh Vijayvergiya, Umashanker Navik, Gurjit Kaur Bhatti, P. Hemachandra Reddy
Ageing Research Reviews.2023; 86: 101882. CrossRef
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Neurochemical Research.2023; 48(9): 2674. CrossRef
Speckle-tracking echocardiography provides sensitive measurements of subtle early alterations associated with cardiac dysfunction in T2DM rats
Yanchao Qi, Zhiyan Chen, Bingyan Guo, Zhe Liu, Lijie Wang, Suyun Liu, Lixiang Xue, Meifang Ma, Yajuan Yin, Yongjun Li, Gang Liu
BMC Cardiovascular Disorders.2023;[Epub] CrossRef
Novel insights into the role of mitochondria in diabetic cardiomyopathy: molecular mechanisms and potential treatments
Fumin Zhi, Qian Zhang, Li Liu, Xing Chang, Hongtao Xu
Cell Stress and Chaperones.2023; 28(6): 641. CrossRef
Transcription factor EB: A potential integrated network regulator in metabolic-associated cardiac injury
Weixing Wen, Haoxiao Zheng, Weiwen Li, Guolin Huang, Peng Chen, Xiaolin Zhu, Yue Cao, Jiahuan Li, Xiaohui Huang, Yuli Huang
Metabolism.2023; 147: 155662. CrossRef
Role of STIM1 in the Regulation of Cardiac Energy Substrate Preference
Panpan Liu, Zhuli Yang, Youjun Wang, Aomin Sun
International Journal of Molecular Sciences.2023; 24(17): 13188. CrossRef
Mitochondrial dysfunction at the crossroad of cardiovascular diseases and cancer
Carmine Rocca, Teresa Soda, Ernestina Marianna De Francesco, Marco Fiorillo, Francesco Moccia, Giuseppe Viglietto, Tommaso Angelone, Nicola Amodio
Journal of Translational Medicine.2023;[Epub] CrossRef
Triarylphosphonium compounds as effective vectors for mitochondria-targeted delivery systems: decoration strategies and prospects for clinical application
T. N. Pashirova, A. V. Nemtarev, E. B. Souto, V. F. Mironov
Russian Chemical Reviews.2023; 92(10): RCR5095. CrossRef
Moderate- and High-Intensity Endurance Training Alleviate Diabetes-Induced Cardiac Dysfunction in Rats
Sarah D’Haese, Maxim Verboven, Lize Evens, Dorien Deluyker, Ivo Lambrichts, BO Eijnde, Dominique Hansen, Virginie Bito
Nutrients.2023; 15(18): 3950. CrossRef
Alpha-lipoic acid enhances ischemic postconditioning-mediated improvement of myocardial infarction and apoptosis in diabetic rats with ischemia/reperfusion injury
Sanaz Gholami, Reza Badalzadeh, Alireza Alihemmati
Canadian Journal of Physiology and Pharmacology.2023; 101(12): 682. CrossRef
Concurrent diabetes and heart failure: interplay and novel therapeutic approaches
Qutuba G Karwi, Kim L Ho, Simran Pherwani, Ezra B Ketema, Qiuyu Sun, Gary D Lopaschuk
Cardiovascular Research.2022; 118(3): 686. CrossRef
Ca2+ mishandling and mitochondrial dysfunction: a converging road to prediabetic and diabetic cardiomyopathy
Carolina Jaquenod De Giusti, Julieta Palomeque, Alicia Mattiazzi
Pflügers Archiv - European Journal of Physiology.2022; 474(1): 33. CrossRef
Double-edge sword roles of iron in driving energy production versus instigating ferroptosis
Shuping Zhang, Wei Xin, Gregory J. Anderson, Ruibin Li, Ling Gao, Shuguang Chen, Jiajun Zhao, Sijin Liu
Cell Death & Disease.2022;[Epub] CrossRef
Differential remodelling of mitochondrial subpopulations and mitochondrial dysfunction are a feature of early stage diabetes
Bodour S. Rajab, Sarah Kassab, Connor D. Stonall, Hussam Daghistani, Stephen Gibbons, Mamas Mamas, David Smith, Aleksandr Mironov, Zainab AlBalawi, Yin Hua Zhang, Florence Baudoin, Min Zi, Sukhpal Prehar, Elizabeth J. Cartwright, Ashraf Kitmitto
Scientific Reports.2022;[Epub] CrossRef
GlyNAC (Glycine and N-Acetylcysteine) Supplementation Improves Impaired Mitochondrial Fuel Oxidation and Lowers Insulin Resistance in Patients with Type 2 Diabetes: Results of a Pilot Study
Rajagopal V. Sekhar
Antioxidants.2022; 11(1): 154. CrossRef
Glucose-derived posttranslational modification in cardiovascular disease
Michael Lehrke, Julia Moellmann, Florian Kahles, Nikolaus Marx
Molecular Aspects of Medicine.2022; 86: 101084. CrossRef
Mitochondrial Implications in Cardiovascular Aging and Diseases: The Specific Role of Mitochondrial Dynamics and Shifts
Anastasia V. Poznyak, Tatiana V. Kirichenko, Evgeny E. Borisov, Nikolay K. Shakhpazyan, Andrey G. Kartuesov, Alexander N. Orekhov
International Journal of Molecular Sciences.2022; 23(6): 2951. CrossRef
Editorial: Management of Diabetes and its Complications: A Focus on Endothelial Dysfunction
Shanhu Qiu, Jianhua Ma, Tongzhi Wu
Frontiers in Endocrinology.2022;[Epub] CrossRef
Alternative autophagy: mechanisms and roles in different diseases
Hong Feng, Nian Wang, Nan Zhang, Hai-han Liao
Cell Communication and Signaling.2022;[Epub] CrossRef
Mitochondria-Mediated Cardiovascular Benefits of Sodium-Glucose Co-Transporter 2 Inhibitors
Siarhei A. Dabravolski, Alexander D. Zhuravlev, Andrey G. Kartuesov, Evgeny E. Borisov, Vasily N. Sukhorukov, Alexander N. Orekhov
International Journal of Molecular Sciences.2022; 23(10): 5371. CrossRef
Animal Models of Dysregulated Cardiac Metabolism
Heiko Bugger, Nikole J. Byrne, E. Dale Abel
Circulation Research.2022; 130(12): 1965. CrossRef
Mitochondrial Dynamics and Mitophagy in Cardiometabolic Disease
Jianguo Lin, Jinlong Duan, Qingqing Wang, Siyu Xu, Simin Zhou, Kuiwu Yao
Frontiers in Cardiovascular Medicine.2022;[Epub] CrossRef
Perspectives for Forkhead box transcription factors in diabetic cardiomyopathy: Their therapeutic potential and possible effects of salvianolic acids
Ronghui Han, Hemeng Huang, Weiyi Xia, Jingjin Liu, Hui Luo, Jing Tang, Zhengyuan Xia
Frontiers in Cardiovascular Medicine.2022;[Epub] CrossRef
Molecular and cellular mechanisms in diabetic heart failure: Potential therapeutic targets
Misganaw Asmamaw Mengstie, Endeshaw Chekol Abebe, Awgichew Behaile Teklemariam, Anemut Tilahun Mulu, Assefa Agegnehu Teshome, Edgeit Abebe Zewde, Zelalem Tilahun Muche, Muluken Teshome Azezew
Frontiers in Endocrinology.2022;[Epub] CrossRef
Effect of Chronic Treatment with Uridine on Cardiac Mitochondrial Dysfunction in the C57BL/6 Mouse Model of High-Fat Diet–Streptozotocin-Induced Diabetes
Natalia V. Belosludtseva, Vlada S. Starinets, Irina B. Mikheeva, Maxim N. Belosludtsev, Mikhail V. Dubinin, Galina D. Mironova, Konstantin N. Belosludtsev
International Journal of Molecular Sciences.2022; 23(18): 10633. CrossRef
FGF21–Sirtuin 3 Axis Confers the Protective Effects of Exercise Against Diabetic Cardiomyopathy by Governing Mitochondrial Integrity
Leigang Jin, Leiluo Geng, Lei Ying, Lingling Shu, Kevin Ye, Ranyao Yang, Yan Liu, Yao Wang, Yin Cai, Xue Jiang, Qin Wang, Xingqun Yan, Boya Liao, Jie Liu, Fuyu Duan, Gary Sweeney, Connie Wai Hong Woo, Yu Wang, Zhengyuan Xia, Qizhou Lian, Aimin Xu
Circulation.2022; 146(20): 1537. CrossRef
Novel Insights Into Molecular Mechanism of Mitochondria in Diabetic Cardiomyopathy
Jing Bai, Chuanbin Liu, Pingjun Zhu, Yang Li
Frontiers in Physiology.2021;[Epub] CrossRef
Mitochondrial Dysfunction Increases Arrhythmic Triggers and Substrates; Potential Anti-arrhythmic Pharmacological Targets
Khalil Saadeh, Ibrahim Talal Fazmin
Frontiers in Cardiovascular Medicine.2021;[Epub] CrossRef
Prostaglandin E receptor subtype 4 protects against diabetic cardiomyopathy by modulating cardiac fatty acid metabolism via FOXO1/CD36 signalling
Fan Ying, Hao Liu, Eva Hoi Ching Tang, Ishan Lakhani, Ningning Liu, Zhengyuan Xia, Shiming Liu
Biochemical and Biophysical Research Communications.2021; 548: 196. CrossRef
Study of long non-coding RNA and mitochondrial dysfunction in diabetic rats
Haytham K. Sultan, Wael M. El-Ayat, Azza H. AbouGhalia, Noha N. Lasheen, Amr S. Moustafa
Tissue and Cell.2021; 71: 101516. CrossRef
A Role of Glucose Overload in Diabetic Cardiomyopathy in Nonhuman Primates
Xiu Wang, Shi Jin, Weina Hu, Gaetano Santulli
Journal of Diabetes Research.2021; 2021: 1. CrossRef
Dysregulation of circulating miRNAs promotes the pathogenesis of diabetes-induced cardiomyopathy
Uzair Ahmed, Usman Ali Ashfaq, Muhammad Qasim, Imtiaz Ahmad, Hafiz Usman Ahmad, Muhammad Tariq, Muhammad Shareef Masoud, Saba Khaliq, Muhammad Younas Khan Barozai
PLOS ONE.2021; 16(4): e0250773. CrossRef
MicroRNAs Regulating Mitochondrial Function in Cardiac Diseases
Guang-Qiong Zhang, Sheng-Quan Wang, Yan Chen, Ling-Yun Fu, Yi-Ni Xu, Ling Li, Ling Tao, Xiang-Chun Shen
Frontiers in Pharmacology.2021;[Epub] CrossRef
Effects of omega-3 fatty acids and metformin combination on diabetic cardiomyopathy in rats through autophagic pathway
Salma M. Eraky, Nehal M. Ramadan
The Journal of Nutritional Biochemistry.2021; 97: 108798. CrossRef
Adropin Alleviates Myocardial Fibrosis in Diabetic Cardiomyopathy Rats: A Preliminary Study
Mao Liu, Jiao Ai, Zhuang Shuai, Kai Tang, Zongyu Li, Yin Huang
Frontiers in Cardiovascular Medicine.2021;[Epub] CrossRef
Fibrosis of the diabetic heart: Clinical significance, molecular mechanisms, and therapeutic opportunities
Izabela Tuleta, Nikolaos G. Frangogiannis
Advanced Drug Delivery Reviews.2021; 176: 113904. CrossRef
Effect of the MPT Pore Inhibitor Alisporivir on the Development of Mitochondrial Dysfunction in the Heart Tissue of Diabetic Mice
Natalia V. Belosludtseva, Vlada S. Starinets, Irina B. Mikheeva, Dmitriy A. Serov, Maxim E. Astashev, Maxim N. Belosludtsev, Mikhail V. Dubinin, Konstantin N. Belosludtsev
Biology.2021; 10(9): 839. CrossRef
Characterisation of the Myocardial Mitochondria Structural and Functional Phenotype in a Murine Model of Diabetic Cardiomyopathy
Alex M. Parker, Mitchel Tate, Darnel Prakoso, Minh Deo, Andrew M. Willis, David M. Nash, Daniel G. Donner, Simon Crawford, Helen Kiriazis, Cesare Granata, Melinda T. Coughlan, Miles J. De Blasio, Rebecca H. Ritchie
Frontiers in Physiology.2021;[Epub] CrossRef
Radiation‑induced dysfunction of energy metabolism in the heart results in the fibrosis of cardiac tissues
Peng Xu, Yali Yi, Yijing Luo, Zhicheng Liu, Yilin Xu, Jing Cai, Zhimin Zeng, Anwen Liu
Molecular Medicine Reports.2021;[Epub] CrossRef
Heart Failure and Diabetes: Perspective of a Dangerous Association
Liliana E. Favaloro, Roxana D. Ratto, Carla Musso
Current Hypertension Reviews.2021; 17(2): 85. CrossRef
CTRP9 Mediates Protective Effects in Cardiomyocytes via AMPK- and Adiponectin Receptor-Mediated Induction of Anti-Oxidant Response
Bernd Niemann, Ling Li, Dorothee Siegler, Benedikt H. Siegler, Fabienne Knapp, Jakob Hanna, Muhammad Aslam, Michael Kracht, Rainer Schulz, Susanne Rohrbach
Cells.2020; 9(5): 1229. CrossRef
The Hippo Pathway Orchestrates Mitochondrial Quality Control: A Novel Focus on Cardiovascular Diseases
Ying Tan, Cai Lei, Huifang Tang, Xiao Zhu, Guanghui Yi
DNA and Cell Biology.2020; 39(9): 1494. CrossRef
Adeno-Associated Viral Transfer of Glyoxalase-1 Blunts Carbonyl and Oxidative Stresses in Hearts of Type 1 Diabetic Rats
Fadhel A. Alomar, Abdullah Al-Rubaish, Fahad Al-Muhanna, Amein K. Al-Ali, JoEllyn McMillan, Jaipaul Singh, Keshore R. Bidasee
Antioxidants.2020; 9(7): 592. CrossRef
Loss of function of transcription factor EB remodels lipid metabolism and cell death pathways in the cardiomyocyte
Purvi C. Trivedi, Jordan J. Bartlett, Angella Mercer, Logan Slade, Marc Surette, Andrea Ballabio, Stephane Flibotte, Bahira Hussein, Brian Rodrigues, Petra C. Kienesberger, Thomas Pulinilkunnil
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2020; 1866(10): 165832. CrossRef
Rescue of myocardial energetic dysfunction in diabetes through the correction of mitochondrial hyperacetylation by honokiol
Matthew Kerr, Jack J. Miller, Dharendra Thapa, Sophie Stiewe, Kerstin N. Timm, Claudia N. Montes Aparicio, Iain Scott, Damian J. Tyler, Lisa C. Heather
JCI Insight.2020;[Epub] CrossRef
Diabetes Mellitus, Mitochondrial Dysfunction and Ca2+-Dependent Permeability Transition Pore
Konstantin N. Belosludtsev, Natalia V. Belosludtseva, Mikhail V. Dubinin
International Journal of Molecular Sciences.2020; 21(18): 6559. CrossRef
Effects of Standardized Green Tea Extract and Its Main Component, EGCG, on Mitochondrial Function and Contractile Performance of Healthy Rat Cardiomyocytes
Rocchina Vilella, Gianluca Sgarbi, Valeria Naponelli, Monia Savi, Leonardo Bocchi, Francesca Liuzzi, Riccardo Righetti, Federico Quaini, Caterina Frati, Saverio Bettuzzi, Giancarlo Solaini, Donatella Stilli, Federica Rizzi, Alessandra Baracca
Nutrients.2020; 12(10): 2949. CrossRef
Diabetic cardiomyopathy: definition, diagnosis criteria, treatment directions and prevention of heart failure
N. A. Koziolova, P. G. Karavaev, A. S. Veklich
South Russian Journal of Therapeutic Practice.2020; 1(2): 93. CrossRef
Adiponectin protects HL-1 cardiomyocytes against rotenone-induced cytotoxicity through AMPK activation
Biao Li, Baojian Zhang, Na Liu, Keke Wu, Yingxu Ma, Wanyun Zuo, Zuodong Ning, Yaozhong Liu, Chao Sun, Yichao Xiao, Tao Tu, Qiming Liu
Toxicology Letters.2020; 335: 82. CrossRef
Nutrient Sensor mTOR and OGT: Orchestrators of Organelle Homeostasis in Pancreatic β-Cells
Nicholas Esch, Seokwon Jo, Mackenzie Moore, Emilyn U. Alejandro, Yingke Xu
Journal of Diabetes Research.2020; 2020: 1. CrossRef
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Ehtasham Ahmad, Jack Sargeant, Francesco Zaccardi, Kamlesh Khunti, David Webb, Melanie Davies
Pharmaceuticals.2020; 13(12): 427. CrossRef

Original Articles

Technology/Device
Role of MicroRNA-34a in Anti-Apoptotic Effects of Granulocyte-Colony Stimulating Factor in Diabetic Cardiomyopathy: In-Hwa Park, Yi-Sun Song, Hyun-Woo Joo, Guang-Yin Shen, Jin-Hee Seong, Na-Kyoung Shin, Young Jong Cho, Yonggu Lee, Jeong Hun Shin, Young-Hyo Lim, Hyuck Kim, Kyung-Soo Kim; Diabetes Metab J. 2020;44(1):173-185. Published online April 23, 2019; DOI: https://doi.org/10.4093/dmj.2018.0211

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93 Download
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Background

Recent studies have shown that microRNAs (miRNAs) are involved in the process of cardiomyocyte apoptosis. We have previously reported that granulocyte-colony stimulating factor (G-CSF) ameliorated diastolic dysfunction and attenuated cardiomyocyte apoptosis in a rat model of diabetic cardiomyopathy. In this study, we hypothesized a regulatory role of cardiac miRNAs in the mechanism of the anti-apoptotic effect of G-CSF in a diabetic cardiomyopathy rat model.

Methods

Rats were given a high-fat diet and low-dose streptozotocin injection and then randomly allocated to receive treatment with either G-CSF or saline. H9c2 rat cardiomyocytes were cultured under a high glucose (HG) condition to induce diabetic cardiomyopathy in vitro. We examined the extent of apoptosis, miRNA expression, and miRNA target genes in the myocardium and H9c2 cells.

Results

G-CSF treatment significantly decreased apoptosis and reduced miR-34a expression in diabetic myocardium and H9c2 cells under the HG condition. G-CSF treatment also significantly increased B-cell lymphoma 2 (Bcl-2) protein expression as a target for miR-34a. In addition, transfection with an miR-34a mimic significantly increased apoptosis and decreased Bcl-2 luciferase activity in H9c2 cells.

Conclusion

Our results indicate that G-CSF might have an anti-apoptotic effect through down-regulation of miR-34a in a diabetic cardiomyopathy rat model.

Citations

Citations to this article as recorded by

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Juliann G. Kiang, Georgetta Cannon, Matthew G. Olson, Joan T. Smith, Marsha N. Anderson, Min Zhai, M. Victoria Umali, Kevin Ho, Connie Ho, Wanchang Cui, Mang Xiao
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N. A. Koziolova, P. G. Karavaev, A. S. Veklich
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Jin Hwa Kim
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Metabolic Risk/Epidemiology
Association between Non-Alcoholic Steatohepatitis and Left Ventricular Diastolic Dysfunction in Type 2 Diabetes Mellitus: Hokyou Lee, Gyuri Kim, Young Ju Choi, Byung Wook Huh, Byung-Wan Lee, Eun Seok Kang, Bong-Soo Cha, Eun Jig Lee, Yong-ho Lee, Kap Bum Huh; Diabetes Metab J. 2020;44(2):267-276. Published online February 28, 2019; DOI: https://doi.org/10.4093/dmj.2019.0001

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Background

Impaired diastolic heart function has been observed in persons with non-alcoholic fatty liver disease (NAFLD) and/or with type 2 diabetes mellitus (T2DM). However, it is unclear whether NAFLD fibrotic progression, i.e., non-alcoholic steatohepatitis, poses an independent risk for diastolic dysfunction in T2DM. We investigated the association between liver fibrosis and left ventricular (LV) diastolic dysfunction in T2DM.

Methods

We analyzed 606 patients with T2DM, aged ≥50 years, who had undergone liver ultrasonography and pulsed-wave Doppler echocardiography. Insulin sensitivity was measured by short insulin tolerance test. Presence of NAFLD and/or advanced liver fibrosis was determined by abdominal ultrasonography and NAFLD fibrosis score (NFS). LV diastolic dysfunction was defined according to transmitral peak early to late ventricular filling (E/A) ratio and deceleration time, using echocardiography.

Results

LV diastolic dysfunction was significantly more prevalent in the NAFLD versus non-NAFLD group (59.7% vs. 49.0%, P=0.011). When NAFLD was stratified by NFS, subjects with advanced liver fibrosis exhibited a higher prevalence of diastolic dysfunction (49.0%, 50.7%, 61.8%; none, simple steatosis, advanced fibrosis, respectively; P for trend=0.003). In multivariable logistic regression, liver fibrosis was independently associated with diastolic dysfunction (odds ratio [OR], 1.58; 95% confidence interval [CI], 1.07 to 2.34; P=0.022) after adjusting for insulin resistance and cardiometabolic risk factors. This association remained significant in patients without insulin resistance (OR, 4.32; 95% CI, 1.73 to 11.51; P=0.002).

Conclusions

Liver fibrosis was associated with LV diastolic dysfunction in patients with T2DM and may be an independent risk factor for diastolic dysfunction, especially in patients without systemic insulin resistance.

Citations

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Diabetes & Metabolism Journal.2023; 47(2): 220. CrossRef
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World Journal of Cardiology.2023; 15(7): 328. CrossRef
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Cureus.2023;[Epub] CrossRef
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International Journal of Molecular Sciences.2023; 24(18): 14292. CrossRef
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Diabetes & Metabolism Journal.2020; 44(3): 482. CrossRef

Reviews

Complications
My Sweetheart Is Broken: Role of Glucose in Diabetic Cardiomyopathy: Manoja K. Brahma, Mark E. Pepin, Adam R. Wende; Diabetes Metab J. 2017;41(1):1-9. Published online November 15, 2016; DOI: https://doi.org/10.4093/dmj.2017.41.1.1

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Despite overall reductions in heart disease prevalence, the risk of developing heart failure has remained 2-fold greater among people with diabetes. Growing evidence has supported that fluctuations in glucose level and uptake contribute to cardiovascular disease (CVD) by modifying proteins, DNA, and gene expression. In the case of glucose, clinical studies have shown that increased dietary sugars for healthy individuals or poor glycemic control in diabetic patients further increased CVD risk. Furthermore, even after decades of maintaining tight glycemic control, susceptibility to disease progression can persist following a period of poor glycemic control through a process termed "glycemic memory." In response to chronically elevated glucose levels, a number of studies have identified molecular targets of the glucose-mediated protein posttranslational modification by the addition of an O-linked N-acetylglucosamine to impair contractility, calcium sensitivity, and mitochondrial protein function. Additionally, elevated glucose contributes to dysfunction in coupling glycolysis to glucose oxidation, pentose phosphate pathway, and polyol pathway. Therefore, in the "sweetened" environment associated with hyperglycemia, there are a number of pathways contributing to increased susceptibly to "breaking" the heart of diabetics. In this review we will discuss the unique contribution of glucose to heart disease and recent advances in defining mechanisms of action.

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Citations to this article as recorded by

Traditional Chinese Medicine in the Treatment of Diabetic Cardiomyopathy: A Comprehensive Review
Jia-Xin He, Hai-Tao Xiao, Meng-Meng Du, Min Hu, Zu-Guo Zheng
Journal of Cardiovascular Pharmacology.2026; 87(1): 7. CrossRef
Targeting the underlying immune mechanism of diabetes-induced myocardial dysfunction via modulation of SIRT-3/p53/TIGAR/PFKFB-3 and SIRT-3/NF-κB signaling pathways as a potential controlling strategy
Mohamed S. Elsayed, Mahmoud Elshal, Manar G. Helal, Tarek Ibrahim
Biomedicine & Pharmacotherapy.2026; 194: 118901. CrossRef
HIV-pharmacotherapy and pathogenesis of diabetes-induced cardiovascular complications: an updated narrative review
Khanyisa Maswanganyi, Andile Khathi, Mlindeli Gamede
Cardiovascular Research.2026; 122(4): 446. CrossRef
The Metabolic Role of Mitochondria in the Perinatal Cardiac Development and Cardiovascular Diseases
Minghao Li, Ruiyi Zhang, Xinyuan Li, Hefeng Huang
Exploration.2026;[Epub] CrossRef
Sirtuins at the Interface of Glucose Metabolism, Diabetes, and Heart Failure: Metabolic Sensing in Cardiometabolic Disease
Jan Krekora, Jarosław Drożdż, Elzbieta Pawlowska, Janusz Blasiak
International Journal of Molecular Sciences.2026; 27(13): 5780. CrossRef
Aspalathin-rich unfermented Aspalathus linearsis extract mitigates vascular endothelial inflammation by inhibiting the TNF-α/Hexokinase 2/NF-κB signaling pathway
Ya-Pei Wang, Bi-Juan Wang, Hsin-Ying Lu, Christo J.F. Muller, Ying-Yu Kuo, Chieh Huo, Chih-Jen Lai, Shih-Han Huang, Elizabeth Joubert, Chih-Pin Chuu
Journal of Agriculture and Food Research.2025; 21: 101882. CrossRef
Mitochondrial NNT Promotes Diastolic Dysfunction in Cardiometabolic HFpEF
Mark E. Pepin, Philipp J.M. Konrad, Sumra Nazir, Farhad Bazgir, Christoph Maack, Alexander Nickel, Joshua M. Gorman, Mathias Hohl, Friederike Schreiter, Matthias Dewenter, Adriano de Britto Chaves Filho, Almut Schulze, Anja Karlstaedt, Norbert Frey, Chris
Circulation Research.2025; 136(12): 1564. CrossRef
Compound SJ-12 attenuates streptozocin-induced diabetic cardiomyopathy by stabilizing SERCA2a
Shuaijie Lou, Weiwei Zhu, Tianxiang Yu, Qianhui Zhang, Minxiu Wang, Leiming Jin, Yongqiang Xiong, Jiachen Xu, Qinyan Wang, Gaozhi Chen, Guang Liang, Xiang Hu, Wu Luo
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2024; 1870(5): 167140. CrossRef
Generation and Accumulation of Various Advanced Glycation End-Products in Cardiomyocytes May Induce Cardiovascular Disease
Takanobu Takata, Shinya Inoue, Togen Masauji, Katsuhito Miyazawa, Yoshiharu Motoo
International Journal of Molecular Sciences.2024; 25(13): 7319. CrossRef
Landscape of Glycolytic Metabolites and Their Regulating Proteins in Myocardium from Human Heart Failure with Preserved Ejection Fraction
Navid Koleini, Mariam Meddeb, Liang Zhao, Mohammad Keykhaei, Seoyoung Kwon, Farnaz Farshidfar, Virginia S. Hahn, Erika L. Pearce, Kavita Sharma, David A. Kass
European Journal of Heart Failure.2024; 26(9): 1941. CrossRef
Exploring the Mechanism of Cardiorenal Protection with Finerenone Based on Network Pharmacology
Yachen Si, Ying Zhu, Jing Liu, Shuyu Liu, Xiaomin Cai, Ying Gu, Hanqing Li, Fang Pan, Wenjuan Wang, Jianying Shangguan, Rui Liu, Chunsheng Xi, Lijun Wang
Cardiorenal Medicine.2024; 14(1): 334. CrossRef
Recent advances associated with cardiometabolic remodeling in diabetes-induced heart failure
Gaurav Sharma, Shyam S. Chaurasia, Mark A. Carlson, Paras K. Mishra
American Journal of Physiology-Heart and Circulatory Physiology.2024; 327(6): H1327. CrossRef
O304 ameliorates hyperglycemia in mice by dually promoting muscle glucose effectiveness and preserving β-cell function
Stefan Norlin, Jan Axelsson, Madelene Ericsson, Helena Edlund
Communications Biology.2023;[Epub] CrossRef
The role of glycolytic metabolic pathways in cardiovascular disease and potential therapeutic approaches
Shuxian Chen, Yuanming Zou, Chunyu Song, Kexin Cao, Kexin Cai, Yanjiao Wu, Zhaobo Zhang, Danxi Geng, Wei Sun, Nanxiang Ouyang, Naijin Zhang, Zhao Li, Guozhe Sun, Yixiao Zhang, Yingxian Sun, Ying Zhang
Basic Research in Cardiology.2023;[Epub] CrossRef
Silibinin ameliorates the cardiovascular oxidative and inflammatory effects of type-2-diabetic rats exposed to air particulate matter
Olamide O. Awolaja, Akeem O. Lawal, Ibukun M. Folorunso, Olusola O. Elekofehinti, Haruna I. Umar
Polycyclic Aromatic Compounds.2023; 43(7): 6570. CrossRef
The Protective Effect of 11-Keto-β-Boswellic Acid against Diabetic Cardiomyopathy in Rats Entails Activation of AMPK
Jozaa Z. AlTamimi, Nora A. AlFaris, Ghedeir M. Alshammari, Reham I. Alagal, Dalal H. Aljabryn, Mohammed Abdo Yahya
Nutrients.2023; 15(7): 1660. CrossRef
The role of CD36 in cardiovascular disease
Hongyang Shu, Yizhong Peng, Weijian Hang, Jiali Nie, Ning Zhou, Dao Wen Wang
Cardiovascular Research.2022; 118(1): 115. CrossRef
The world congress on insulin resistance, diabetes, and cardiovascular disease (WCIRDC)
Zachary Bloomgarden
Journal of Diabetes.2022; 14(3): 163. CrossRef
Pharmacological modulation of prostaglandin E2 (PGE2) EP receptors improves cardiomyocyte function under hyperglycemic conditions
Karin J. Bosma, Monica Ghosh, Spencer R. Andrei, Lin Zhong, Jennifer C. Dunn, Valerie F. Ricciardi, Juliann B. Burkett, Antonis K. Hatzopoulos, Derek S. Damron, Maureen Gannon
Physiological Reports.2022;[Epub] CrossRef
The efficacy and safety of traditional Chinese medicine treating diabetic cardiomyopathy: A protocol for systematic review and meta-analysis
Shuo Han, Yuan Hou, Huaman Liu, Quanlin Zhao
Medicine.2022; 101(47): e31269. CrossRef
High Throughput Screen Identifies Small Molecule Effectors That Modulate Thin Filament Activation in Cardiac Muscle
Priyanka Parijat, Laszlo Kondacs, Alexander Alexandrovich, Mathias Gautel, Alexander J. A. Cobb, Thomas Kampourakis
ACS Chemical Biology.2021; 16(1): 225. CrossRef
Prostaglandin E receptor subtype 4 protects against diabetic cardiomyopathy by modulating cardiac fatty acid metabolism via FOXO1/CD36 signalling
Fan Ying, Hao Liu, Eva Hoi Ching Tang, Ishan Lakhani, Ningning Liu, Zhengyuan Xia, Shiming Liu
Biochemical and Biophysical Research Communications.2021; 548: 196. CrossRef
Intracellular Toxic AGEs (TAGE) Triggers Numerous Types of Cell Damage
Masayoshi Takeuchi, Akiko Sakasai-Sakai, Takanobu Takata, Jun-ichi Takino, Yoshiki Koriyama, Chigusa Kikuchi, Ayako Furukawa, Kentaro Nagamine, Takamitsu Hori, Tamihide Matsunaga
Biomolecules.2021; 11(3): 387. CrossRef
Phosphorylated and O-GlcNAc Modified IRS-1 (Ser1101) and -2 (Ser1149) Contribute to Human Diabetes Type II
Afshan Kaleem, Sabahat Javed, Nayab Rehman, Roheena Abdullah, Mehwish Iqtedar, Mohammad Nauman Aftab, Daniel C. Hoessli, Ikram-Ul Haq
Protein & Peptide Letters.2021; 28(3): 333. CrossRef
Diabetes and Heart Failure: Multi-Omics Approaches
Akram Tayanloo-Beik, Peyvand Parhizkar Roudsari, Mostafa Rezaei-Tavirani, Mahmood Biglar, Ozra Tabatabaei-Malazy, Babak Arjmand, Bagher Larijani
Frontiers in Physiology.2021;[Epub] CrossRef
Asymptomatic Diabetic Cardiomyopathy: an Underrecognized Entity in Type 2 Diabetes
Ana Maria Stanton, Muthiah Vaduganathan, Lee-Shing Chang, Alexander Turchin, James L. Januzzi, Vanita R. Aroda
Current Diabetes Reports.2021;[Epub] CrossRef
Increased Glucose Availability Attenuates Myocardial Ketone Body Utilization
Manoja K. Brahma, Chae‐Myeong Ha, Mark E. Pepin, Sobuj Mia, Zhihuan Sun, John C. Chatham, Kirk M. Habegger, Evan Dale Abel, Andrew J. Paterson, Martin E. Young, Adam R. Wende
Journal of the American Heart Association.2020;[Epub] CrossRef
Gene therapy targeting cardiac phosphoinositide 3-kinase (p110α) attenuates cardiac remodeling in type 2 diabetes
Darnel Prakoso, Miles J. De Blasio, Mitchel Tate, Helen Kiriazis, Daniel G. Donner, Hongwei Qian, David Nash, Minh Deo, Kate L. Weeks, Laura J. Parry, Paul Gregorevic, Julie R. McMullen, Rebecca Helen Ritchie
American Journal of Physiology-Heart and Circulatory Physiology.2020; 318(4): H840. CrossRef
The Potential Role of MicroRNA in Diabetic Cardiomyopathy
Jin Hwa Kim
Diabetes & Metabolism Journal.2020; 44(1): 54. CrossRef
Re-balancing cellular energy substrate metabolism to mend the failing heart
Jan F.C. Glatz, Miranda Nabben, Martin E. Young, P. Christian Schulze, Heinrich Taegtmeyer, Joost J.F.P. Luiken
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2020; 1866(5): 165579. CrossRef
The Peroxisome Proliferator-Activated Receptor-Gamma Coactivator-1α–Heme Oxygenase 1 Axis, a Powerful Antioxidative Pathway with Potential to Attenuate Diabetic Cardiomyopathy
Maayan Waldman, Michael Arad, Nader G. Abraham, Edith Hochhauser
Antioxidants & Redox Signaling.2020; 32(17): 1273. CrossRef
miR‑155 modulates high glucose‑induced cardiac fibrosis via the Nrf2/HO‑1 signaling pathway
Yu Li, Jing‑Zhu Duan, Qian He, Chong‑Quan Wang
Molecular Medicine Reports.2020;[Epub] CrossRef
Disruption of energy utilization in diabetic cardiomyopathy; a mini review
Shinsuke Nirengi, Carmem Peres Valgas da Silva, Kristin I Stanford
Current Opinion in Pharmacology.2020; 54: 82. CrossRef
Reduced fatty acid uptake aggravates cardiac contractile dysfunction in streptozotocin-induced diabetic cardiomyopathy
Yogi Umbarawan, Ryo Kawakami, Mas Rizky A. A. Syamsunarno, Norimichi Koitabashi, Hideru Obinata, Aiko Yamaguchi, Hirofumi Hanaoka, Takako Hishiki, Noriyo Hayakawa, Hiroaki Sunaga, Hiroki Matsui, Masahiko Kurabayashi, Tatsuya Iso
Scientific Reports.2020;[Epub] CrossRef
Metabolomics biomarkers and the risk of overall mortality and ESRD in CKD: Results from the Progredir Cohort
Silvia M. Titan, Gabriela Venturini, Kallyandra Padilha, Alessandra C. Goulart, Paulo A. Lotufo, Isabela J. Bensenor, Jose E. Krieger, Ravi I. Thadhani, Eugene P. Rhee, Alexandre C. Pereira, Vivekanand Jha
PLOS ONE.2019; 14(3): e0213764. CrossRef
Chronic hyperglycemia as a risk factor in implant therapy
Fawad Javed, Georgios E. Romanos
Periodontology 2000.2019; 81(1): 57. CrossRef
Recent advances in the pathogenesis of microvascular complications in diabetes
Sungmi Park, Hyeon-Ji Kang, Jae-Han Jeon, Min-Ji Kim, In-Kyu Lee
Archives of Pharmacal Research.2019; 42(3): 252. CrossRef
Nutrient regulation of signaling and transcription
Gerald W. Hart
Journal of Biological Chemistry.2019; 294(7): 2211. CrossRef
Intracellular toxic advanced glycation end-products in cardiomyocytes may cause cardiovascular disease
Takanobu Takata, Akiko Sakasai-Sakai, Tadashi Ueda, Masayoshi Takeuchi
Scientific Reports.2019;[Epub] CrossRef
Effects of Exercise to Improve Cardiovascular Health
Kelsey Pinckard, Kedryn K. Baskin, Kristin I. Stanford
Frontiers in Cardiovascular Medicine.2019;[Epub] CrossRef
A new hyperpolarized 13C ketone body probe reveals an increase in acetoacetate utilization in the diabetic rat heart
Desiree Abdurrachim, Chern Chiuh Woo, Xing Qi Teo, Wei Xin Chan, George K. Radda, Philip Teck Hock Lee
Scientific Reports.2019;[Epub] CrossRef
Chronic O-GlcNAcylation and Diabetic Cardiomyopathy: The Bitterness of Glucose
Simon Ducheix, Jocelyne Magré, Bertrand Cariou, Xavier Prieur
Frontiers in Endocrinology.2018;[Epub] CrossRef
Proteomics of the Rat Myocardium during Development of Type 2 Diabetes Mellitus Reveals Progressive Alterations in Major Metabolic Pathways
Anders Valdemar Edhager, Jonas Agerlund Povlsen, Bo Løfgren, Hans Erik Bøtker, Johan Palmfeldt
Journal of Proteome Research.2018; 17(7): 2521. CrossRef
Protective effects of astaxanthin on diabetic cardiomyopathy in rats
Bingshan Zhang, Di Xu
CyTA - Journal of Food.2018; 16(1): 909. CrossRef
Au cœur de la cardiomyopathie diabétique
Alexandre Lugat, Michael Joubert, Bertrand Cariou, Xavier Prieur
médecine/sciences.2018; 34(6-7): 563. CrossRef
Redox imbalance stress in diabetes mellitus: Role of the polyol pathway
Liang‐jun Yan
Animal Models and Experimental Medicine.2018; 1(1): 7. CrossRef
Heart rate dynamics during cardio-pulmonary exercise testing are associated with glycemic control in individuals with type 1 diabetes
Othmar Moser, Max L. Eckstein, Olivia McCarthy, Rachel Deere, Stephen C. Bain, Hanne L. Haahr, Eric Zijlstra, Tim Heise, Richard M. Bracken, Petter Bjornstad
PLOS ONE.2018; 13(4): e0194750. CrossRef
Resistance exercise improves cardiac function and mitochondrial efficiency in diabetic rat hearts
Tae Hee Ko, Jubert C. Marquez, Hyoung Kyu Kim, Seung Hun Jeong, SungRyul Lee, Jae Boum Youm, In Sung Song, Dae Yun Seo, Hye Jin Kim, Du Nam Won, Kyoung Im Cho, Mun Gi Choi, Byoung Doo Rhee, Kyung Soo Ko, Nari Kim, Jong Chul Won, Jin Han
Pflügers Archiv - European Journal of Physiology.2018; 470(2): 263. CrossRef
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Kaviyarasi Renu, V.G. Abilash, P.B. Tirupathi Pichiah, Thabassum Akthar Syeda, Sankarganesh Arunachalam
Asian Pacific Journal of Tropical Biomedicine.2017; 7(11): 1041. CrossRef
Proteome profiling in the aorta and kidney of type 1 diabetic rats
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PLOS ONE.2017; 12(11): e0187752. CrossRef

Diabetic Cardiomyopathy and Its Prevention by Nrf2: Current Status: Jing Chen, Zhiguo Zhang, Lu Cai; Diabetes Metab J. 2014;38(5):337-345. Published online October 17, 2014; DOI: https://doi.org/10.4093/dmj.2014.38.5.337

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Diabetic cardiomyopathy (DCM), as one of the major cardiac complications in diabetic patients, is known to related with oxidative stress that is due to a severe imbalance between reactive oxygen species (ROS) and/or reactive nitrogen species (RNS) generation and their clearance by antioxidant defense systems. Transcription factor nuclear factor NF-E2-related factor 2 (Nrf2) plays an important role in maintaining the oxidative homeostasis by regulating multiple downstream antioxidants. Diabetes may up-regulate several antioxidants in the heart as a compensative mechanism at early stage, but at late stage, diabetes not only generates extra ROS and/or RNS but also impairs antioxidant capacity in the heart, including Nrf2. In an early study, we have established that Nrf2 protect the cardiac cells and heart from high level of glucose in vitro and hyperglycemia in vivo, and in the following study demonstrated the significant down-regulation of cardiac Nrf2 expression in diabetic animals and patients. Using Nrf2-KO mice or Nrf2 inducers, blooming evidence has indicated the important protection by Nrf2 from cardiac pathogenesis in the diabetes. Therefore, this brief review summarizes the status of studies on Nrf2's role in preventing DCM and even other complications, the need for new and safe Nrf2 inducer screening and the precaution for the undesirable side of Nrf2 under certain conditions.

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JCI Insight.2026;[Epub] CrossRef
Inflammation at the crossroads: A bibliometric and integrative review of metabolic-cardiac links in diabetic cardiomyopathy (2004–2024)
Jinxu Fang, Rongsheng Jiang, Kaiqiang Zhang, Long Zhang, Qifan Guan, Likun Zheng, Lanying Yao, Yi Tan, Mingjun Liu
Medicine.2026; 105(29): e49844. CrossRef
Elucidating the therapeutic potential of natural products in alleviating diabetic cardiomyopathy: contemporary progress and forthcoming opportunities
Daozheng Fang, Judyta Cielecka-Piontek, Renald Blundell, Zhangfeng Zhong, Jihang Chen
Phytomedicine.2026; 161: 158707. CrossRef
Modulation of PPAR-γ/Nrf2 and AGE/RAGE signaling contributes to the chrysin cardioprotection against myocardial damage following ischemia/reperfusion in diabetic rats
Neha Rani, Dharamvir Singh Arya
Journal of Pharmacy and Pharmacology.2025; 77(6): 794. CrossRef
Novel insights into the central protective role of ACE2 in diabetic cardiomyopathy: from underlying signaling pathways to therapeutic perspectives
Xinyi Li, Shunlin Qu
Molecular and Cellular Biochemistry.2025; 480(6): 3535. CrossRef
Diabetic Cardiomyopathy: An Update on Emerging Pathological Mechanisms
Chirag Kakkar, Veerta Sharma, Ashi Mannan, Gaurav Gupta, Sachin Singh, Puneet Kumar, Kamal Dua, Amarjot Kaur, Shareen Singh, Sonia Dhiman, Thakur Gurjeet Singh
Current Cardiology Reviews.2025;[Epub] CrossRef
Mechanistic insights into temoporfin-based photodynamic therapy: Ferroptosis as a critical regulator under normoxic and hypoxic conditions in head and neck cancer
Tong-Hong Wang, Li-Fang Chou, Yen-Wen Shen, Nan-Chin Lin, Yin-Hwa Shih, Tzong-Ming Shieh
Journal of Photochemistry and Photobiology B: Biology.2025; 267: 113165. CrossRef
Senkyunolide A mitigates lipid deposition in hyperlipidemic hepatocytes through SIRT6-mediated suppression of oxidative stress and fetuin-A
Jun Hwi Ko, Tae Woo Jung, Min Kyung Pyo, Do Su Lim, Hyeon Ji Gwon, A.M. Abd El-Aty, Rıdvan Yağan, Jong Wook Shin, Moo Yeol Lee, Jin-Ho Song, Ji Hoon Jeong
Biochemical and Biophysical Research Communications.2025; 771: 152046. CrossRef
Erianin mitigates diabetic cardiomyopathy via adenosine monophosphate-activated protein kinase-nuclear factor erythroid 2-related factor 2-heme oxygenase-1 pathway activation
Jia-Hui Chen, Xiao-Chun Dai, Zi-Jiao Quan, Xin-Yu Liu
World Journal of Diabetes.2025;[Epub] CrossRef
The role of Nrf2 signaling pathway in diabetic cardiomyopathy: from pathogenesis to traditional Chinese medicine interventions
Huixian Gu, Junchang Liu, Jie Jiang, Hongyan Ma, Siyu Wu, Longfei Sun, Lan Yao
Frontiers in Cardiovascular Medicine.2025;[Epub] CrossRef
Agomelatine and empagliflozin synergistically protect against diabetic cardiomyopathy via nrf2/HO-1 signaling
Nada A. Elbaik, Shimaa M. Elshazly, Atef El-Gharbawy, Mahmoud H. Elbatreek
European Journal of Pharmacology.2025; 1005: 178054. CrossRef
Paraquat-induced neurotoxicity: Mechanisms and potential therapies
Roghayeh Jahani, Hamidreza Mohammadi
Letters in Drug Design & Discovery.2025; 22(11): 100258. CrossRef
Beyond Hepatoprotection—The Cardioprotective Effects of Bicyclol in Diabetes
Arun Samidurai, Rakesh C. Kukreja
Cardiovascular Drugs and Therapy.2024; 38(3): 411. CrossRef
Natural Products and Health
Joanna Bartkowiak-Wieczorek, Edyta Mądry
Nutrients.2024; 16(3): 415. CrossRef
Nrf2 prevents diabetic cardiomyopathy via antioxidant effect and normalization of glucose and lipid metabolism in the heart
Ge Yang, Qihe Zhang, Chao Dong, Guowen Hou, Jinjie Li, Xin Jiang, Ying Xin
Journal of Cellular Physiology.2024;[Epub] CrossRef
3,4′,5-Trimethoxy-trans-stilbene ameliorates hepatic insulin resistance and oxidative stress in diabetic obese mice through insulin and Nrf2 signaling pathways
Yi Tan, Chunxiu Zhou, Lingchao Miao, Xutao Zhang, Haroon Khan, Baojun Xu, Wai San Cheang
Food & Function.2024; 15(6): 2996. CrossRef
The signaling pathways of selected traditional Chinese medicine prescriptions and their metabolites in the treatment of diabetic cardiomyopathy: a review
Wencan Li, Xiang Liu, Zheng Liu, Qichang Xing, Renzhu Liu, Qinxuan Wu, Yixiang Hu, Jiani Zhang
Frontiers in Pharmacology.2024;[Epub] CrossRef
Phycocyanin attenuates skeletal muscle damage and fatigue via modulation of Nrf2 and IRS-1/AKT/mTOR pathway in exercise-induced oxidative stress in rats
Sayomphu Puengpan, Amnat Phetrungnapha, Sarawut Sattayakawee, Sakara Tunsophon, Keisuke Hitachi
PLOS ONE.2024; 19(9): e0310138. CrossRef
Cannabinoid 2 Receptor Activation Protects against Diabetic Cardiomyopathy through Inhibition of AGE/RAGE-Induced Oxidative Stress, Fibrosis, and Inflammasome Activation
Hebaallah Mamdouh Hashiesh, Sheikh Azimullah, Mohamed Fizur Nagoor Meeran, Dhanya Saraswathiamma, Seenipandi Arunachalam, Niraj Kumar Jha, Bassem Sadek, Ernest Adeghate, Gautam Sethi, Alia Albawardi, Saeeda Al Marzooqi, Shreesh Ojha
The Journal of Pharmacology and Experimental Therapeutics.2024; 391(2): 241. CrossRef
From Microcirculation to Aging-Related Diseases: A Focus on Endothelial SIRT1
Martin Law, Pei-Chun Wang, Zhong-Yan Zhou, Yu Wang
Pharmaceuticals.2024; 17(11): 1495. CrossRef
Concerning influences of micro/nano plastics on female reproductive health: focusing on cellular and molecular pathways from animal models to human studies
Hasti Balali, Ali Morabbi, Mohammad Karimian
Reproductive Biology and Endocrinology.2024;[Epub] CrossRef
Natural compounds protect against the pathogenesis of osteoarthritis by mediating the NRF2/ARE signaling
Zhenyu Wu, Zhouxin Yang, Luying Liu, Yong Xiao
Frontiers in Pharmacology.2023;[Epub] CrossRef
High fat diet exacerbates long-term metabolic, neuropathological, and behavioral derangements in an experimental mouse model of traumatic brain injury
Stanley Ibeh, Nour-Mounira Z. Bakkar, Fatima Ahmad, Judith Nwaiwu, Chloe Barsa, Sarine Mekhjian, Mohammad Amine Reslan, Ali H. Eid, Hayat Harati, Sanaa Nabha, Yehia Mechref, Ahmed F. El-Yazbi, Firas Kobeissy
Life Sciences.2023; 314: 121316. CrossRef
The Protective Effect of 11-Keto-β-Boswellic Acid against Diabetic Cardiomyopathy in Rats Entails Activation of AMPK
Jozaa Z. AlTamimi, Nora A. AlFaris, Ghedeir M. Alshammari, Reham I. Alagal, Dalal H. Aljabryn, Mohammed Abdo Yahya
Nutrients.2023; 15(7): 1660. CrossRef
Caffeic Acid Phenethyl Ester and Caffeamide Derivatives Suppress Oral Squamous Cell Carcinoma Cells
Yin-Hwa Shih, Chieh-Chieh Chen, Yueh-Hsiung Kuo, Lih-Jyh Fuh, Wan-Chen Lan, Tong-Hong Wang, Kuo-Chou Chiu, Thanh-Hien Vu Nguyen, Shih-Min Hsia, Tzong-Ming Shieh
International Journal of Molecular Sciences.2023; 24(12): 9819. CrossRef
The Role of Asiatic Acid in Preventing Dental Pulp Inflammation: An in-vivo Study
Arlina Nurhapsari, Risya Cilmiaty, Adi Prayitno, Bambang Purwanto, Soetrisno Soetrisno
Clinical, Cosmetic and Investigational Dentistry.2023; Volume 15: 109. CrossRef
Dexmedetomidine ameliorates diabetic cardiomyopathy by inhibiting ferroptosis through the Nrf2/GPX4 pathway
Fan Li, Zhenfei Hu, Yidan Huang, Haiting Zhan
Journal of Cardiothoracic Surgery.2023;[Epub] CrossRef
Metformin-mediated epigenetic modifications in diabetes and associated conditions: Biological and clinical relevance
Roberta Giordo, Anna Maria Posadino, Arduino Aleksander Mangoni, Gianfranco Pintus
Biochemical Pharmacology.2023; 215: 115732. CrossRef
Transient receptor potential vanilloid type 1: cardioprotective effects in diabetic models
Jiaqi Bao, Zhicheng Gao, Yilan Hu, Lifang Ye, Lihong Wang
Channels.2023;[Epub] CrossRef
Sinapic acid ameliorates cardiac dysfunction and cardiomyopathy by modulating NF-κB and Nrf2/HO-1 signaling pathways in streptozocin induced diabetic rats
Mohammad Raish, Ajaz Ahmad, Yousef A. Bin Jardan, Mudassar Shahid, Khalid M. Alkharfy, Abdul Ahad, Mushtaq Ahmad Ansari, Ibrahim Abdelsalam Abdelrahman, Fahad I. Al-Jenoobi
Biomedicine & Pharmacotherapy.2022; 145: 112412. CrossRef
Recent Advances in KEAP1/NRF2 -Targeting Strategies by Phytochemical Antioxidants, Nanoparticles, and Biocompatible Scaffolds for the Treatment of Diabetic Cardiovascular Complications
Andrea Rampin, Michele Carrabba, Martina Mutoli, Charlotte L. Eman, Gianluca Testa, Paolo Madeddu, Gaia Spinetti
Antioxidants & Redox Signaling.2022; 36(10-12): 707. CrossRef
Exercise and Urtica Dioica extract ameliorate mitochondrial function and the expression of cardiac muscle Nuclear Respiratory Factor 2 and Peroxisome proliferator-activated receptor Gamma Coactivator 1-alpha in STZ-induced diabetic rats
Seyyedeh Masoumeh Seyydi, Asghar Tofighi, Masoud Rahmati, Javad Tolouei Azar
Gene.2022; 822: 146351. CrossRef
3,3′,4,5′-Tetramethoxy-trans-stilbene Improves Insulin Resistance by Activating the IRS/PI3K/Akt Pathway and Inhibiting Oxidative Stress
Yi Tan, Lingchao Miao, Jianbo Xiao, Wai San Cheang
Current Issues in Molecular Biology.2022; 44(5): 2175. CrossRef
The Beneficial Effects of Chinese Herbal Monomers on Ameliorating Diabetic Cardiomyopathy via Nrf2 Signaling
Yiwei Gao, Wu Liu, Xin Su, Xinyi Li, Fangning Yu, Ning Zhang, Yuli Huang
Oxidative Medicine and Cellular Longevity.2022;[Epub] CrossRef
Cardioprotective Effects and in-silico Antioxidant Mechanism of L-Ergothioneine in Experimental Type-2 Diabetic Rats
Ayobami Dare, Ahmed A Elrashedy, Mahendra L. Channa, Anand Nadar
Cardiovascular & Hematological Agents in Medicinal Chemistry.2022; 20(2): 133. CrossRef
Molecular Mechanisms of Ferroptosis and Relevance to Cardiovascular Disease
Lai-Hua Xie, Nadezhda Fefelova, Sri Harika Pamarthi, Judith K. Gwathmey
Cells.2022; 11(17): 2726. CrossRef
Cardiac adaptation and cardioprotection against arrhythmias and ischemia-reperfusion injury in mammalian hibernators
Lai-Hua Xie, Judith K. Gwathmey, Zhenghang Zhao
Pflügers Archiv - European Journal of Physiology.2021; 473(3): 407. CrossRef
Cardioprotective Effect of Glycyrrhizin on Myocardial Remodeling in Diabetic Rats
Vikram Thakur, Narah Alcoreza, Monica Delgado, Binata Joddar, Munmun Chattopadhyay
Biomolecules.2021; 11(4): 569. CrossRef
Therapeutic potential of targeting oxidative stress in diabetic cardiomyopathy
Nikole J. Byrne, Namakkal S. Rajasekaran, E Dale Abel, Heiko Bugger
Free Radical Biology and Medicine.2021; 169: 317. CrossRef
Punicalagin Protects Against Diabetic Cardiomyopathy by Promoting Opa1-Mediated Mitochondrial Fusion via Regulating PTP1B-Stat3 Pathway
Feng Fu, Chaoyang Liu, Rui Shi, Man Li, Min Zhang, Yanyan Du, Qiaojuan Wang, Jun Li, Guoen Wang, Jianming Pei, Mingge Ding
Antioxidants & Redox Signaling.2021; 35(8): 618. CrossRef
Elevated type I interferon responses potentiate metabolic dysfunction, inflammation, and accelerated aging in mtDNA mutator mice
Yuanjiu Lei, Camila Guerra Martinez, Sylvia Torres-Odio, Samantha L. Bell, Christine E. Birdwell, Joshua D. Bryant, Carl W. Tong, Robert O. Watson, Laura Ciaccia West, A. Phillip West
Science Advances.2021;[Epub] CrossRef
The potential role of Keap1-Nrf2 pathway in the pathogenesis of Alzheimer’s disease, type 2 diabetes, and type 2 diabetes-related Alzheimer’s disease
Ling He, Yi Sun
Metabolic Brain Disease.2021; 36(7): 1469. CrossRef
The impact of mitochondria on cancer treatment resistance
Michelle van der Merwe, Gustav van Niekerk, Carla Fourie, Manisha du Plessis, Anna-Mart Engelbrecht
Cellular Oncology.2021; 44(5): 983. CrossRef
Therapeutic Approaches Targeting Proteostasis in Kidney Disease and Fibrosis
Jia-Huang Chen, Chia-Hsien Wu, Chih-Kang Chiang
International Journal of Molecular Sciences.2021; 22(16): 8674. CrossRef
Coronary Large Conductance Ca2+-Activated K+ Channel Dysfunction in Diabetes Mellitus
Tong Lu, Hon-Chi Lee
Frontiers in Physiology.2021;[Epub] CrossRef
Ferroptosis: New Dawn for Overcoming the Cardio-Cerebrovascular Diseases
Meng-Yi Luo, Jian-Hui Su, Shao-Xin Gong, Na Liang, Wen-Qian Huang, Wei Chen, Ai-Ping Wang, Ying Tian
Frontiers in Cell and Developmental Biology.2021;[Epub] CrossRef
Recombinant Human Growth Hormone Inhibits Lipotoxicity, Oxidative Stress, and Apoptosis in a Mouse Model of Diabetic Cardiomyopathy
Zuowei Pei, Xiang Wang, Chenguang Yang, Min Dong, Fang Wang, Juan Gambini
Oxidative Medicine and Cellular Longevity.2021;[Epub] CrossRef
Hydrogen sulfide mitigates myocardial inflammation by inhibiting nucleotide-binding oligomerization domain-like receptor protein 3 inflammasome activation in diabetic rats
Qiang Jia, Shomaila Mehmood, Xiaofen Liu, Shanfeng Ma, Rui Yang
Experimental Biology and Medicine.2020; 245(3): 221. CrossRef
Heme oxygenase-1 in protozoan infections: A tale of resistance and disease tolerance
Rafael C. M. C. Silva, Leonardo H. Travassos, Claudia N. Paiva, Marcelo T. Bozza, Marc-Jan Gubbels
PLOS Pathogens.2020; 16(7): e1008599. CrossRef
Distinct Approaches of Raloxifene: Its Far-Reaching Beneficial Effects Implicating the HO-System
Denise Börzsei, Renáta Szabó, Alexandra Hoffmann, Médea Veszelka, Imre Pávó, Zsolt Turcsán, Csaba Viczián, Krisztina Kupai, Csaba Varga, Anikó Pósa
Biomolecules.2020; 10(3): 375. CrossRef
The Mitochondria: A Target of Polyphenols in the Treatment of Diabetic Cardiomyopathy
Humna Bhagani, Suzanne A. Nasser, Ali Dakroub, Ahmed F. El-Yazbi, Assaad A. Eid, Firas Kobeissy, Gianfranco Pintus, Ali H. Eid
International Journal of Molecular Sciences.2020; 21(14): 4962. CrossRef
The Effects of Dietary Supplements that Overactivate the Nrf2/ARE System
Robert E. Smith
Current Medicinal Chemistry.2020; 27(13): 2077. CrossRef
Allopurinol reduces oxidative stress and activates Nrf2/p62 to attenuate diabetic cardiomyopathy in rats
Jierong Luo, Dan Yan, Sisi Li, Shiming Liu, Fei Zeng, Chi Wai Cheung, Hong Liu, Michael G. Irwin, Huansen Huang, Zhengyuan Xia
Journal of Cellular and Molecular Medicine.2020; 24(2): 1760. CrossRef
Rg1 protects H9C2 cells from high glucose‐/palmitate‐induced injury via activation of AKT/GSK‐3β/Nrf2 pathway
Haitao Yu, Juan Zhen, Yang Yang, Jian Du, Jiyan Leng, Qian Tong
Journal of Cellular and Molecular Medicine.2020; 24(14): 8194. CrossRef
Ranolazine protects against diabetic cardiomyopathy by activating the NOTCH1/NRG1 pathway
Xi Chen, Long Ren, Xing Liu, Xi Sun, Chaorun Dong, Yanan Jiang, Ying Qin, Huan Qu, Jinfeng Jiao, Shuo Wang, Yunlong Bai, Baofeng Yang
Life Sciences.2020; 261: 118306. CrossRef
Low Concentration of Withaferin a Inhibits Oxidative Stress-Mediated Migration and Invasion in Oral Cancer Cells
Tzu-Jung Yu, Jen-Yang Tang, Fu Ou-Yang, Yen-Yun Wang, Shyng-Shiou F. Yuan, Kevin Tseng, Li-Ching Lin, Hsueh-Wei Chang
Biomolecules.2020; 10(5): 777. CrossRef
Protective Effect of Simplicillium sp. Ethyl Acetate Extract against High Glucose‐Induced Oxidative Stress in HUVECs
Ting-Ting Tian, Qi-Rui Li, Shi-Quan Gan, Chu-Rui Chang, Xiang-Chun Shen, Shao-Hsuan Kao
Evidence-Based Complementary and Alternative Medicine.2020;[Epub] CrossRef
Deneysel Diyabet Oluşturulan Sıçanlarda Kalp ve İskelet Kası Nrf2 Yapımı ve Oksidatif Stres Üzerine Melatoninin Etkisinin İncelenmesi
Salim ÖZENOĞLU, İnci TURAN, Hale SAYAN ÖZAÇMAK, Veysel Haktan ÖZAÇMAK
Turkish Journal of Diabetes and Obesity.2020; 4(1): 46. CrossRef
Nicorandil alleviates apoptosis in diabetic cardiomyopathy through PI3K/Akt pathway
Xuyang Wang, Jinyu Pan, Dian Liu, Mingjun Zhang, Xiaowei Li, Jingjing Tian, Ming Liu, Tao Jin, Fengshuang An
Journal of Cellular and Molecular Medicine.2019; 23(8): 5349. CrossRef
Bailcalin Protects against Diabetic Cardiomyopathy through Keap1/Nrf2/AMPK-Mediated Antioxidative and Lipid-Lowering Effects
Ran Li, Yuan Liu, Ying-guang Shan, Lu Gao, Fang Wang, Chun-guang Qiu
Oxidative Medicine and Cellular Longevity.2019; 2019: 1. CrossRef
Omega 3 rich diet modulates energy metabolism via GPR120-Nrf2 crosstalk in a novel antioxidant mouse model
Deborah Amos, Carla Cook, Nalini Santanam
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids.2019; 1864(4): 466. CrossRef
Increased placental expressions of nuclear factor erythroid 2–related factor 2 and antioxidant enzymes in gestational diabetes: Protective mechanisms against the placental oxidative stress?
Balachandiran Manoharan, Zachariah Bobby, Gowri Dorairajan, Sajini Elizabeth Jacob, Victorraj Gladwin, Vickneshwaran Vinayagam, Rajaa Muthu Packirisamy
European Journal of Obstetrics & Gynecology and Reproductive Biology.2019; 238: 78. CrossRef
Another look at phenolic compounds in cancer therapy the effect of polyphenols on ubiquitin-proteasome system
Aleksandra Golonko, Tomasz Pienkowski, Renata Swislocka, Ryszard Lazny, Marek Roszko, Wlodzimierz Lewandowski
European Journal of Medicinal Chemistry.2019; 167: 291. CrossRef
Hydrogen sulfide-mediated regulation of cell death signaling ameliorates adverse cardiac remodeling and diabetic cardiomyopathy
Sumit Kar, Tyler N. Kambis, Paras K. Mishra
American Journal of Physiology-Heart and Circulatory Physiology.2019; 316(6): H1237. CrossRef
Genomic and Genetic Approaches to Deciphering Acute Respiratory Distress Syndrome Risk and Mortality
Heather Lynn, Xiaoguang Sun, Nancy Casanova, Manuel Gonzales-Garay, Christian Bime, Joe G.N. Garcia
Antioxidants & Redox Signaling.2019; 31(14): 1027. CrossRef
Enhanced Keap1-Nrf2 signaling protects the myocardium from isoproterenol-induced pathological remodeling in mice
Gobinath Shanmugam, Anil Kumar Challa, Silvio H. Litovsky, Asokan Devarajan, Ding Wang, Dean P. Jones, Victor M. Darley-Usmar, Namakkal Soorappan Rajasekaran
Redox Biology.2019; 27: 101212. CrossRef
Effects of PP2A/Nrf2 on experimental diabetes mellitus-related cardiomyopathy by regulation of autophagy and apoptosis through ROS dependent pathway
Yanhui Guan, Lichun Zhou, Yu Zhang, Huiqin Tian, Anqi Li, Xiuzhen Han
Cellular Signalling.2019; 62: 109339. CrossRef
An Aza resveratrol–chalcone derivative 6b protects mice against diabetic cardiomyopathy by alleviating inflammation and oxidative stress
Shengban You, Jianchang Qian, Chuchu Sun, Hailing Zhang, Shiju Ye, Taiwei Chen, Zheng Xu, Jingying Wang, Weijian Huang, Guang Liang
Journal of Cellular and Molecular Medicine.2018; 22(3): 1931. CrossRef
Oxidative Stress in Mesenchymal Stem Cell Senescence: Regulation by Coding and Noncoding RNAs
Rosa Vono, Eva Jover Garcia, Gaia Spinetti, Paolo Madeddu
Antioxidants & Redox Signaling.2018; 29(9): 864. CrossRef
An overview of the emerging interface between cardiac metabolism, redox biology and the circadian clock
Rodrigo A. Peliciari-Garcia, Victor Darley-Usmar, Martin E. Young
Free Radical Biology and Medicine.2018; 119: 75. CrossRef
Klotho protects the heart from hyperglycemia-induced injury by inactivating ROS and NF-κB-mediated inflammation both in vitro and in vivo
Yue Guo, Xiaodong Zhuang, Zena Huang, Jing Zou, Daya Yang, Xun Hu, Zhimin Du, Lichun Wang, Xinxue Liao
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease.2018; 1864(1): 238. CrossRef
Paradoxical cardiotoxicity of intraperitoneally-injected epigallocatechin gallate preparation in diabetic mice
Nora O. Abdel Rasheed, Lamiaa A. Ahmed, Dalaal M. Abdallah, Bahia M. El-Sayeh
Scientific Reports.2018;[Epub] CrossRef
Oxidative stress-induced miR-27a targets the redox gene nuclear factor erythroid 2-related factor 2 in diabetic embryopathy
Yang Zhao, Daoyin Dong, E. Albert Reece, Ashley R. Wang, Peixin Yang
American Journal of Obstetrics and Gynecology.2018; 218(1): 136.e1. CrossRef
Regulation on SIRT1-PGC-1α/Nrf2 pathway together with selective inhibition of aldose reductase makes compound hr5F a potential agent for the treatment of diabetic complications
Zhihua Wang, Sheng Yuan, Yanbing Li, Zhe Zhang, Wei Xiao, Dan Tang, Kaihe Ye, Zhijun Liu, Congcong Wang, Yixiong Zheng, Hong Nie, Heru Chen
Biochemical Pharmacology.2018; 150: 54. CrossRef
Fibroblast growth factor-21 prevents diabetic cardiomyopathy via AMPK-mediated antioxidation and lipid-lowering effects in the heart
Hong Yang, Anyun Feng, Sundong Lin, Lechu Yu, Xiufei Lin, Xiaoqing Yan, Xuemian Lu, Chi Zhang
Cell Death & Disease.2018;[Epub] CrossRef
Salusin-β contributes to oxidative stress and inflammation in diabetic cardiomyopathy
Ming-Xia Zhao, Bing Zhou, Li Ling, Xiao-Qing Xiong, Feng Zhang, Qi Chen, Yue-Hua Li, Yu-Ming Kang, Guo-Qing Zhu
Cell Death & Disease.2017; 8(3): e2690. CrossRef
Role of Nrf2 Signaling in the Regulation of Vascular BK Channel β1 Subunit Expression and BK Channel Function in High-Fat Diet–Induced Diabetic Mice
Tong Lu, Xiaojing Sun, Yong Li, Qiang Chai, Xiao-Li Wang, Hon-Chi Lee
Diabetes.2017; 66(10): 2681. CrossRef
Regulation of vascular large-conductance calcium-activated potassium channels by Nrf2 signalling
Yong Li, Xiao-Li Wang, Xiaojing Sun, Qiang Chai, Jingchao Li, Benjamin Thompson, Win-Kuang Shen, Tong Lu, Hon-Chi Lee
Diabetes and Vascular Disease Research.2017; 14(4): 353. CrossRef
Metallothionein Is Downstream of Nrf2 and Partially Mediates Sulforaphane Prevention of Diabetic Cardiomyopathy
Junlian Gu, Yanli Cheng, Hao Wu, Lili Kong, Shudong Wang, Zheng Xu, Zhiguo Zhang, Yi Tan, Bradley B. Keller, Honglan Zhou, Yuehui Wang, Zhonggao Xu, Lu Cai
Diabetes.2017; 66(2): 529. CrossRef
Kimchi methanol extracts attenuate hepatic steatosis induced by high cholesterol diet in low-density lipoprotein receptor knockout mice through inhibition of endoplasmic reticulum stress
Minji Woo, Mijeong Kim, Jeong Sook Noh, Yeong Ok Song
Journal of Functional Foods.2017; 32: 218. CrossRef
Aspalathin Protects the Heart against Hyperglycemia-Induced Oxidative Damage by Up-Regulating Nrf2 Expression
Phiwayinkosi Dludla, Christo Muller, Elizabeth Joubert, Johan Louw, M. Essop, Kwazi Gabuza, Samira Ghoor, Barbara Huisamen, Rabia Johnson
Molecules.2017; 22(1): 129. CrossRef
Intermittent hypoxia-induced cardiomyopathy and its prevention by Nrf2 and metallothionein
Shanshan Zhou, Xia Yin, Jingpeng Jin, Yi Tan, Daniel J. Conklin, Ying Xin, Zhiguo Zhang, Weixia Sun, Taixing Cui, Jun Cai, Yang Zheng, Lu Cai
Free Radical Biology and Medicine.2017; 112: 224. CrossRef
Inhibitory effects of rosmarinic acid on pterygium epithelial cells through redox imbalance and induction of extrinsic and intrinsic apoptosis
Ya-Yu Chen, Chia-Fang Tsai, Ming-Chu Tsai, Yu-Wen Hsu, Fung-Jou Lu
Experimental Eye Research.2017; 160: 96. CrossRef
Pathophysiological Fundamentals of Diabetic Cardiomyopathy
Xinyue Hu, Tao Bai, Zheng Xu, Qiuju Liu, Yang Zheng, Lu Cai
Comprehensive Physiology.2017; 7(2): 693. CrossRef
Ischemia reperfusion injury, ischemic conditioning and diabetes mellitus
Anne Lejay, Fei Fang, Rohan John, Julie A.D. Van, Meredith Barr, Fabien Thaveau, Nabil Chakfe, Bernard Geny, James W. Scholey
Journal of Molecular and Cellular Cardiology.2016; 91: 11. CrossRef
The Role of the Nrf2/ARE Antioxidant System in Preventing Cardiovascular Diseases
Robert Smith, Kevin Tran, Cynthia Smith, Miranda McDonald, Pushkar Shejwalkar, Kenji Hara
Diseases.2016; 4(4): 34. CrossRef
Prohibitin overexpression improves myocardial function in diabetic cardiomyopathy
Wen-qian Dong, Min Chao, Qing-hua Lu, Wei-li Chai, Wei Zhang, Xue-ying Chen, Er-shun Liang, Ling-bo Wang, Hong-liang Tian, Yu-guo Chen, Ming-xiang Zhang
Oncotarget.2016; 7(1): 66. CrossRef
Restoration of Nrf2 Signaling Normalizes the Regenerative Niche
Marc A. Soares, Oriana D. Cohen, Yee Cheng Low, Rita A. Sartor, Trevor Ellison, Utkarsh Anil, Lavinia Anzai, Jessica B. Chang, Pierre B. Saadeh, Piul S. Rabbani, Daniel J. Ceradini
Diabetes.2016; 65(3): 633. CrossRef
Myocardial transcription factors in diastolic dysfunction: clues for model systems and disease
Alexander T. Mikhailov, Mario Torrado
Heart Failure Reviews.2016; 21(6): 783. CrossRef
Antioxidant Properties of Whole Body Periodic Acceleration (pGz)
Arkady Uryash, Jorge Bassuk, Paul Kurlansky, Francisco Altamirano, Jose R. Lopez, Jose A. Adams, Guillermo López Lluch
PLOS ONE.2015; 10(7): e0131392. CrossRef
Mulberry leaves (Morus alba L.) ameliorate obesity-induced hepatic lipogenesis, fibrosis, and oxidative stress in high-fat diet-fed mice
Ji-Young Ann, Hyeyoon Eo, Yunsook Lim
Genes & Nutrition.2015;[Epub] CrossRef
Oxidative Stress and Human Hypertension: Vascular Mechanisms, Biomarkers, and Novel Therapies
Augusto C. Montezano, Maria Dulak-Lis, Sofia Tsiropoulou, Adam Harvey, Ana M. Briones, Rhian M. Touyz
Canadian Journal of Cardiology.2015; 31(5): 631. CrossRef
Haeme oxygenase signalling pathway: implications for cardiovascular disease
Laura E. Fredenburgh, Allison A. Merz, Susan Cheng
European Heart Journal.2015; 36(24): 1512. CrossRef
Glucose Homeostasis and Cardiovascular Alterations in Diabetes
Lusha Xiang, Peter N. Mittwede, John S. Clemmer
Comprehensive Physiology.2015; 5(4): 1815. CrossRef

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