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- Brown Fat as a Regulator of Systemic Metabolism beyond Thermogenesis
- Okamatsu-Ogura Yuko, Masayuki Saito
- Diabetes Metab J. 2021;45(6):840-852. Published online June 25, 2021
- DOI: https://doi.org/10.4093/dmj.2020.0291
- 9,095 View
- 507 Download
- 17 Crossref
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Graphical Abstract
Abstract
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PubReader 
ePub - Brown adipose tissue (BAT) is a specialized tissue for nonshivering thermogenesis to dissipate energy as heat. Although BAT research has long been limited mostly in small rodents, the rediscovery of metabolically active BAT in adult humans has dramatically promoted the translational studies on BAT in health and diseases. Moreover, several remarkable advancements have been made in brown fat biology over the past decade: The molecular and functional analyses of inducible thermogenic adipocytes (socalled beige adipocytes) arising from a developmentally different lineage from classical brown adipocytes have been accelerated. In addition to a well-established thermogenic activity of uncoupling protein 1 (UCP1), several alternative thermogenic mechanisms have been discovered, particularly in beige adipocytes. It has become clear that BAT influences other peripheral tissues and controls their functions and systemic homeostasis of energy and metabolic substrates, suggesting BAT as a metabolic regulator, other than for thermogenesis. This notion is supported by discovering that various paracrine and endocrine factors are secreted from BAT. We review the current understanding of BAT pathophysiology, particularly focusing on its role as a metabolic regulator in small rodents and also in humans.
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Citations
Citations to this article as recorded by
- Brown adipose tissue evaluation using water and triglyceride as indices by diffuse reflectance spectroscopy
Tomomi Iida, Yukio Ueda, Hideo Tsukada, Dai Fukumoto, Takafumi Hamaoka
Journal of Biophotonics.2024;[Epub] CrossRef - White-brown adipose tissue interplay in polycystic ovary syndrome: Therapeutic avenues
Khadijeh Abbasi, Reza Zarezadeh, Amir Valizadeh, Amir Mehdizadeh, Hamed Hamishehkar, Mohammad Nouri, Masoud Darabi
Biochemical Pharmacology.2024; 220: 116012. CrossRef - Brown Adipose Tissue, Batokines, and Bioactive Compounds in Foods: An Update
Fabiane Ferreira Martins, Bruna Cadete Martins, Ananda Vitoria Silva Teixeira, Matheus Ajackson, Vanessa Souza‐Mello, Julio Beltrame Daleprane
Molecular Nutrition & Food Research.2024;[Epub] CrossRef - Plasticity of Adipose Tissues: Interconversion among White, Brown, and Beige Fat and Its Role in Energy Homeostasis
Yanqiu Peng, Lixia Zhao, Min Li, Yunfei Liu, Yuke Shi, Jian Zhang
Biomolecules.2024; 14(4): 483. CrossRef - Homotaurine exhibits contrasting effects of DRD1-mediated thermogenesis-related regulators in C2C12 myoblasts and 3T3−L1 white adipocytes
Kiros Haddish, Jong Won Yun
Biotechnology and Bioprocess Engineering.2024;[Epub] CrossRef - Thermogenic Brown Fat in Humans: Implications in Energy Homeostasis, Obesity and Metabolic Disorders
Masayuki Saito, Yuko Okamatsu-Ogura
The World Journal of Men's Health.2023; 41(3): 489. CrossRef - Interplay of skeletal muscle and adipose tissue: sarcopenic obesity
Min Jeong Park, Kyung Mook Choi
Metabolism.2023; 144: 155577. CrossRef - White adipose tissue undergoes browning during preweaning period in association with microbiota formation in mice
Anju Tsukada, Yuko Okamatsu-Ogura, Emi Futagawa, Yuki Habu, Natsumi Takahashi, Mira Kato-Suzuki, Yuko Kato, Satoshi Ishizuka, Kei Sonoyama, Kazuhiro Kimura
iScience.2023; 26(7): 107239. CrossRef - In situ fluorescence-photoacoustic measurement of the changes of brown adipose tissue in mice under hindlimb unloading
Baojie Gong, Jianxin Tang, Xiaoxiao Jiang, Zhe Zhang, Shiying Li, Hongjun Jin, Liming Nie, Guojia Huang
Journal of Applied Physiology.2023; 135(2): 251. CrossRef - Age-Related Expression Dynamics of Uncoupling Protein 1 in Adipose Tissues of ICR Outbred Mice during Postnatal Ontogenesis
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Hamed Alizadeh Pahlavani
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Antioxidants.2021; 10(9): 1418. CrossRef
- Brown adipose tissue evaluation using water and triglyceride as indices by diffuse reflectance spectroscopy
- Obesity and Metabolic Syndrome
- Brown Fat and Browning for the Treatment of Obesity and Related Metabolic Disorders
- So Hun Kim, Jorge Plutzky
- Diabetes Metab J. 2016;40(1):12-21. Published online January 21, 2016
- DOI: https://doi.org/10.4093/dmj.2016.40.1.12
- 7,430 View
- 110 Download
- 155 Web of Science
- 158 Crossref
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Abstract
PDFPubReader
Brown fat is a specialized fat depot that can increase energy expenditure and produce heat. After the recent discovery of the presence of active brown fat in human adults and novel transcription factors controlling brown adipocyte differentiation, the field of the study of brown fat has gained great interest and is rapidly growing. Brown fat expansion and/or activation results in increased energy expenditure and a negative energy balance in mice and limits weight gain. Brown fat is also able to utilize blood glucose and lipid and results in improved glucose metabolism and blood lipid independent of weight loss. Prolonged cold exposure and beta adrenergic agonists can induce browning of white adipose tissue. The inducible brown adipocyte, beige adipocyte evolving by thermogenic activation of white adipose tissue have different origin and molecular signature from classical brown adipocytes but share the characteristics of high mitochondria content, UCP1 expression and thermogenic capacity when activated. Increasing browning may also be an efficient way to increase whole brown fat activity. Recent human studies have shown possibilities that findings in mice can be reproduced in human, making brown fat a good candidate organ to treat obesity and its related disorders.
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Citations
Citations to this article as recorded by- Modulation of angiogenic switch in reprogramming browning and lipid metabolism in white adipocytes
Sreelekshmi Sreekumar, Karyath Palliyath Gangaraj, Manikantan Syamala Kiran
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- DOI: https://doi.org/10.4093/dmj.2013.37.2.85
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Abstract
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Obesity gives vent to many diseases such as type 2 diabetes, hypertension, and hyperlipidemia, being considered as the main causes of mortality and morbidity worldwide. The pathogenesis and pathophysiology of metabolic syndrome can well be understood by studying the molecular mechanisms that control the development and function of adipose tissue. In human body, exist two types of adipose tissue, the white and the brown one, which are reported to play various roles in energy homeostasis. The major and most efficient storage of energy occurs in the form of triglycerides in white adipose tissue while brown adipose tissue actively participates in both basal and inducible energy consumption in the form of thermogenesis. Recent years have observed a rapid and greater interest towards developmental plasticity and therapeutic potential of stromal cells those isolated from adipose tissue. The adipocyte differentiation involves a couple of regulators in the white or brown adipogenesis. Peroxisome proliferators-activated receptor-γ actively participates in regulating carbohydrate and lipid metabolism, and also acts as main regulator of both white and brown adipogenesis. This review based on our recent research, seeks to highlight the adipocyte differentiation.
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Citations
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- Brown Adipose Tissue as a Regulator of Energy Expenditure and Body Fat in Humans
- Masayuki Saito
- Diabetes Metab J. 2013;37(1):22-29. Published online February 15, 2013
- DOI: https://doi.org/10.4093/dmj.2013.37.1.22
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Abstract
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Brown adipose tissue (BAT) is recognized as the major site of sympathetically activated nonshivering thermogenesis during cold exposure and after spontaneous hyperphagia, thereby controling whole-body energy expenditure and body fat. In adult humans, BAT has long been believed to be absent or negligible, but recent studies using fluorodeoxyglucose-positron emission tomography, in combination with computed tomography, demonstrated the existence of metabolically active BAT in healthy adult humans. Human BAT is activated by acute cold exposure, being positively correlated to cold-induced increases in energy expenditure. The metabolic activity of BAT differs among individuals, being lower in older and obese individuals. Thus, BAT is recognized as a regulator of whole-body energy expenditure and body fat in humans as in small rodents, and a hopeful target combating obesity and related disorders. In fact, there are some food ingredients such as capsaicin and capsinoids, which have potential to activate and recruit BAT via activity on the specific receptor, transient receptor potential channels, thereby increasing energy expenditure and decreasing body fat modestly and consistently.
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