Diabetes & Metabolism Journal

Review

Basic Research
Brown Fat as a Regulator of Systemic Metabolism beyond Thermogenesis: Okamatsu-Ogura Yuko, Masayuki Saito; Diabetes Metab J. 2021;45(6):840-852. Published online June 25, 2021; DOI: https://doi.org/10.4093/dmj.2020.0291

9,100 View
507 Download
17 Crossref

Graphical Abstract Abstract PDF PubReader ePub

Brown adipose tissue (BAT) is a specialized tissue for nonshivering thermogenesis to dissipate energy as heat. Although BAT research has long been limited mostly in small rodents, the rediscovery of metabolically active BAT in adult humans has dramatically promoted the translational studies on BAT in health and diseases. Moreover, several remarkable advancements have been made in brown fat biology over the past decade: The molecular and functional analyses of inducible thermogenic adipocytes (socalled beige adipocytes) arising from a developmentally different lineage from classical brown adipocytes have been accelerated. In addition to a well-established thermogenic activity of uncoupling protein 1 (UCP1), several alternative thermogenic mechanisms have been discovered, particularly in beige adipocytes. It has become clear that BAT influences other peripheral tissues and controls their functions and systemic homeostasis of energy and metabolic substrates, suggesting BAT as a metabolic regulator, other than for thermogenesis. This notion is supported by discovering that various paracrine and endocrine factors are secreted from BAT. We review the current understanding of BAT pathophysiology, particularly focusing on its role as a metabolic regulator in small rodents and also in humans.

Citations

Citations to this article as recorded by

Brown adipose tissue evaluation using water and triglyceride as indices by diffuse reflectance spectroscopy
Tomomi Iida, Yukio Ueda, Hideo Tsukada, Dai Fukumoto, Takafumi Hamaoka
Journal of Biophotonics.2024;[Epub] CrossRef
White-brown adipose tissue interplay in polycystic ovary syndrome: Therapeutic avenues
Khadijeh Abbasi, Reza Zarezadeh, Amir Valizadeh, Amir Mehdizadeh, Hamed Hamishehkar, Mohammad Nouri, Masoud Darabi
Biochemical Pharmacology.2024; 220: 116012. CrossRef
Brown Adipose Tissue, Batokines, and Bioactive Compounds in Foods: An Update
Fabiane Ferreira Martins, Bruna Cadete Martins, Ananda Vitoria Silva Teixeira, Matheus Ajackson, Vanessa Souza‐Mello, Julio Beltrame Daleprane
Molecular Nutrition & Food Research.2024;[Epub] CrossRef
Plasticity of Adipose Tissues: Interconversion among White, Brown, and Beige Fat and Its Role in Energy Homeostasis
Yanqiu Peng, Lixia Zhao, Min Li, Yunfei Liu, Yuke Shi, Jian Zhang
Biomolecules.2024; 14(4): 483. CrossRef
Homotaurine exhibits contrasting effects of DRD1-mediated thermogenesis-related regulators in C2C12 myoblasts and 3T3−L1 white adipocytes
Kiros Haddish, Jong Won Yun
Biotechnology and Bioprocess Engineering.2024;[Epub] CrossRef
Thermogenic Brown Fat in Humans: Implications in Energy Homeostasis, Obesity and Metabolic Disorders
Masayuki Saito, Yuko Okamatsu-Ogura
The World Journal of Men's Health.2023; 41(3): 489. CrossRef
Interplay of skeletal muscle and adipose tissue: sarcopenic obesity
Min Jeong Park, Kyung Mook Choi
Metabolism.2023; 144: 155577. CrossRef
White adipose tissue undergoes browning during preweaning period in association with microbiota formation in mice
Anju Tsukada, Yuko Okamatsu-Ogura, Emi Futagawa, Yuki Habu, Natsumi Takahashi, Mira Kato-Suzuki, Yuko Kato, Satoshi Ishizuka, Kei Sonoyama, Kazuhiro Kimura
iScience.2023; 26(7): 107239. CrossRef
In situ fluorescence-photoacoustic measurement of the changes of brown adipose tissue in mice under hindlimb unloading
Baojie Gong, Jianxin Tang, Xiaoxiao Jiang, Zhe Zhang, Shiying Li, Hongjun Jin, Liming Nie, Guojia Huang
Journal of Applied Physiology.2023; 135(2): 251. CrossRef
Age-Related Expression Dynamics of Uncoupling Protein 1 in Adipose Tissues of ICR Outbred Mice during Postnatal Ontogenesis
A. V. Yakunenkov, E. I. Elsukova, I. O. Natochy
Journal of Evolutionary Biochemistry and Physiology.2023; 59(4): 1020. CrossRef
UNCOUPLING PROTEIN UCP1 EXPRESSION DYNAMICS IN ADIPOSE TISSUES OF THE OUTBRED ICR MICE IN POSTNATAL ONTOGENESIS
A. V. Yakunenkov, E. I. Elsukova, I. O. Natochy
Журнал эволюционной биохимии и физиологии.2023; 59(4): 255. CrossRef
Antibodies Regulate Dual-Function Enzyme IYD to Induce Functional Synergy between Metabolism and Thermogenesis
Sunghyun Kang, Hwan-Woo Park, Kyung Ho Han
International Journal of Molecular Sciences.2022; 23(14): 7834. CrossRef
Machine learning-featured Secretogranin V is a circulating diagnostic biomarker for pancreatic adenocarcinomas associated with adipopenia
Yunju Jo, Min-Kyung Yeo, Tam Dao, Jeongho Kwon, Hyon‐Seung Yi, Dongryeol Ryu
Frontiers in Oncology.2022;[Epub] CrossRef
Possible roles of exercise and apelin against pregnancy complications
Hamed Alizadeh Pahlavani
Frontiers in Endocrinology.2022;[Epub] CrossRef
Relationships between the expression of adipose genes and profiles of hospitalized dogs
Yukina Sugiyama, Fumie Shimokawa, Kazutoshi Sugiyama, Takashi Kobayashi, Yusuke Yamashita, Kei Kazama, Ken Onda, Masayuki Funaba, Masaru Murakami
Veterinary Research Communications.2022; 46(4): 1239. CrossRef
Garlic (Allium sativum L.) in diabetes and its complications: Recent advances in mechanisms of action
Yayi Jiang, Rensong Yue, Guojie Liu, Jun Liu, Bo Peng, Maoyi Yang, Lianxue Zhao, Zihan Li
Critical Reviews in Food Science and Nutrition.2022; : 1. CrossRef
Fruit of Gardenia jasminoides Induces Mitochondrial Activation and Non-Shivering Thermogenesis through Regulation of PPARγ
Woo Yong Park, Gahee Song, Ja Yeon Park, Kwan-Il Kim, Kwang Seok Ahn, Hyun Jeong Kwak, Jungtae Leem, Jae-Young Um, Jinbong Park
Antioxidants.2021; 10(9): 1418. CrossRef

First
Prev
Page of 1
Next
Last

Search