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Volume 32(5); October 2008
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Review
Oxidative Stress and Cell Dysfunction in Diabetes: Role of ROS Produced by Mitochondria and NAD(P)H Oxidase.
Sang Soo Kim, Seok Man Son
Korean Diabetes J. 2008;32(5):389-398.   Published online October 1, 2008
DOI: https://doi.org/10.4093/kdj.2008.32.5.389
  • 2,188 View
  • 62 Download
  • 10 Crossref
AbstractAbstract PDF
Oxidative stress has been considered to be a major contributor to the pathogenesis of the diabetic macrovascular and microvascular complications. In the absence of an appropriate antioxidant defense mechanism, increased oxidative stress leads to the activation of stress-sensitive intracellular signaling pathways and the formation of gene products that cause damage and contribute to the late complications ofdiabetes. The source of reactive oxygen species (ROS) in the pancreatic beta cells and insulin sensitive cells has postulated to be the mitochondrial electron transport chain. NAD(P)H oxidase-dependent ROS production is also important as the source both in pancreatic beta cells and other cells. NAD(P)H oxidase mediated ROS can alter parameters of signal transduction, insulin secretion, insulin action, cell proliferation and cell death. Additionally, oxidative stress as the pathogenic mechanism linking insulin resistance with dysfunction of both pancreatic beta cells and endothelial cells, eventually leads to diabetes and its complications. Further investigation of the mechanisms and its therapeutic interventions based on focusing NAD(P)H oxidase associated ROS production in the islet cells and other islet cells are needed

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  • Cytoprotective Effect of Hot-Water Extracts of Protaetia brevitarsis seulensis Larvae in Cisplatin-Treated Macrophages
    Bo-Gyeong Yoo, Jun-Pyo Hong, Ha-Yeon Song, Eui-Hong Byun
    Journal of the Korean Society of Food Science and Nutrition.2022; 51(12): 1252.     CrossRef
  • The Effects of LR and SP Acupuncture on Renal Damage in Streptozotocin-induced Diabetic Mice
    Cho In Lee, Hyun Jong Lee, Yun Kyu Lee, Seong Chul Lim, Jae Soo Kim
    The Acupuncture.2015; 32(3): 41.     CrossRef
  • Effect of Chungkukjang supplementation on oxidative stress and antioxidant nutrients of diabetic rats induced by streptozotocin
    Heyun-Sook Park, Hyun-Joo Kong, Eon-Hee Lee, Eun-Mi Choi, Joung-Hyeon Jang, Myoung-Hee Lee, Ju-Yeon Hong, Su-Jung Hwang, Hyeon-A Jung, Kyung-Mi Yang
    Korean Journal of Food Preservation.2015; 22(2): 281.     CrossRef
  • The Effects of Several Halophytes on Insulin Resistance in Otsuka Long-evans Tokushima Fatty Rats
    Jeong-Yong Cho, Zhangjun Huang, Sun-Young Park, Kyung-Hee Park, Tong-Kun Pai, So-Young Kim, Haeng-Ran Kim, Kyung-Sik Ham
    Korean Journal of Food Science and Technology.2014; 46(1): 100.     CrossRef
  • Protective Effects of Radiation-induced Blackberry Mutant Extract on Carbon Tetrachloride (CCl4)-induced Liver Injury in Sprague-Dawley Rats
    Byoung Ok Cho, Chang-Wook Lee, Yangkang So, Chang-Hyun Jin, Hong-Sun Yook, Myung-Woo Byun, Yong-Wook Jeong, Jong Chun Park, Il-Yun Jeong
    Journal of the Korean Society of Food Science and Nutrition.2014; 43(6): 807.     CrossRef
  • Antioxidant Activities and α-Glucosidase Inhibitory Effect of Water Extracts from Medicinal Plants
    Hyun Sook Kim, Tae Woo Kim, Dae Jung Kim, Jae Sung Lee, Kyoung Kon Kim, Myeon Choe
    Korean Journal of Medicinal Crop Science.2013; 21(3): 197.     CrossRef
  • Antioxidant Effect of Hot water and Ethanol extracts from Cheonnyuncho (Opuntia humifusa) on Reactive Oxygen Species (ROS) Production in 3T3-L1 Adipocytes
    Bo-Ra Yoon, Young-Jun Lee, Sun-Gu Kim, Jung-Young Jang, Hyo-Ku Lee, Seong-Kap Rhee, Hee-Do Hong, Hyeon-Son Choi, Boo-Yong Lee, Ok-Hwan Lee
    Korean Journal of Food Preservation.2012; 19(3): 443.     CrossRef
  • Inhibitory Effects of Panax ginseng C. A. Mayer Treated with High Temperature and High Pressure on Oxidative Stress
    Bo-Ra Yoon, Young-Jun Lee, Hee-Do Hong, Young-Chul Lee, Young-Chan Kim, Young Kyoung Rhee, Kyung-Tack Kim, Ok-Hwan Lee
    The Korean Journal of Food And Nutrition.2012; 25(4): 800.     CrossRef
  • Effect of Dietary Supplementation of β-Carotene on Hepatic Antioxidant Enzyme Activities and Glutathione Concentration in Diabetic Rats
    Jung-Hyun Jang, Kyeung-Soon Lee, Jung-Sook Seo
    Journal of the Korean Society of Food Science and Nutrition.2011; 40(8): 1092.     CrossRef
  • An Association between 609 C →T Polymorphism in NAD(P)H: Quinone Oxidoreductase 1 (NQO1) Gene and Blood Glucose Levels in Korean Population
    Dohee Kim
    Korean Diabetes Journal.2009; 33(1): 24.     CrossRef
Editorial
Association Study of the Peroxisome Proliferators-Activated Receptor gamma2 Pro12Ala Polymorphism with Diabetic Nephropathy.
Min Jeong Kwon, Jeong Hyun Park
Korean Diabetes J. 2008;32(5):399-401.   Published online October 1, 2008
DOI: https://doi.org/10.4093/kdj.2008.32.5.399
  • 1,708 View
  • 16 Download
AbstractAbstract PDF
No abstract available.
Original Articles
Association Study of the Peroxisome Proliferators-Activated Receptor gamma2 Pro12Ala Polymorphism with Diabetic Nephropathy.
Kyu Ho Lee, Hee Seog Jeong, Khan Young Choi, Hyun Kim, Dal Sic Lee, Ji Young Kang, Hyun Jeong Jeon, Tae Keun Oh
Korean Diabetes J. 2008;32(5):402-408.   Published online October 1, 2008
DOI: https://doi.org/10.4093/kdj.2008.32.5.402
  • 1,941 View
  • 16 Download
AbstractAbstract PDF
BACKGROUND
Peroxisome proliferators-activated receptor gamma (PPARgamma) is a member of the nuclear hormone receptor superfamily of ligand-activated transcription factors and known to play a role in regulating the expression of numerous genes involved in lipid metabolism, metabolic syndrome, inflammation, and atherosclerosis. The PPARgamma2 Pro12Ala polymorphism has recently been shown to be associated with diabetic nephropathy. In this study, we evaluated the relationship between PPARgamma2 Pro12Ala polymorphism and type 2 diabetic nephropathy whose duration of diabetes was over 10 years. METHODS: We conducted a case-control study, which enrolled 367 patients with type 2 diabetes. Genotyping of PPARgamma2 Pro12Ala polymorphism was performed using polymerase chain reaction followed by digestion with Hae III restriction enzyme. RESULTS: The genotype or allele frequencies of PPARgamma2 Pro12Ala polymorphism were not significantly different in diabetic patients with or without diabetic nephropathy. The genotype frequencies in terms of diabetic retinopathy and macrovascular complications such as coronary artery disease or stroke were not different either. Interestingly, nephropathy patients with Ala/Pro genotype showed lower C-peptide levels than those of Pro/Pro genotype. CONCLUSION: Our results suggest that PPARgamma2 Pro12Ala polymorphism is not associated with diabetic nephropathy in type 2 diabetic patients.
Association of Serum Cystatin C with Metabolic Syndrome and Its Related Components in Korean Adults.
Sun Young Kim, Sang Heon Song, Yun Kyung Jeon, Ji Ryang Kim, Jung Ho Bae, Sang Soo Kim, Soo Hyung Lee, Seok Man Son, In Ju Kim, Yong Ki Kim, Yang Ho Kang
Korean Diabetes J. 2008;32(5):409-417.   Published online October 1, 2008
DOI: https://doi.org/10.4093/kdj.2008.32.5.409
  • 2,441 View
  • 21 Download
  • 3 Crossref
AbstractAbstract PDF
BACKGROUND
Serum cystatin C has been reported as a better marker than serum creatinine for estimation of kidney function and may be associated with cardiovascular disease. The aim of this study was to elucidate the association of serum cystatin C with metabolic syndrome (MS), a constellation of cardiovascular risk factors, and its related components and the usefulness of serum cystatin C for the cardiovascular risk assessment. METHODS: 1,468 healthy subjects (814 men and 655 women), who visited health promotion center of Pusan National University Hospital for routine medical checkup were included. MS was defined by modified, revised National Cholesterol Education Program (NCEP) Adult Treatment Panel (ATP) III criteria. RESULTS: Mean serum cystatin C value was 0.87 +/- 0.17 mg/L. In partial correlation analysis adjusted by age, sex and Glomerular Filtration Rate (GFR), cystatin C was associated with most of metabolic parameters and especially had significant positive correlation with waist circumference (r = 0.215), triglyceride (TG) (r = 0.141), diastolic blood pressure (BP) (r = 0.116), and correlated negatively with high density lipoprotein (HDL) cholesterol (r = -0.152) (all P < 0.001). There were increasing trends of prevalence of MS with the increase of quartiles of cystatin C and as the number of MS components increased, cystatin C values significantly increased. Serum cystatin C was also significantly increased in MS (0.90 +/- 0.19 mg/L vs. 0.86 +/- 0.16 mg/L). In stepwise multiple regression analysis including the components of MS, Waist circumference, diastolic BP, triglyceride, and HDL cholesterol were independent determinants of serum cystatin C, but with creatinine, only waist circumference was independent determinant. CONCLUSIONS: Serum cystatin C was closely associated with MS and its related cardiovascular risk factors and might be useful as a tool of cardiovascular risk assessment.

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  • Cystatin C in Patients of Metabolic Syndrome and its Correlation with the Individual Components of Metabolic Syndrome
    Sunita Aghade, Jayshree S Bavikar, Pragati S Kadam, Reshakiran J Shendye
    Indian Journal of Medical Biochemistry.2019; 23(2): 293.     CrossRef
  • Cystatin C as a Predictor for Diabetes according to Glycosylated Hemoglobin Levels in Korean Patients
    Eon Ju Jeon, Ji Hyun Lee
    Diabetes & Metabolism Journal.2016; 40(1): 32.     CrossRef
  • Association of Obesity with Serum Cystatin C in Korean Adults
    Yang Ho Kang
    The Korean Journal of Obesity.2015; 24(4): 199.     CrossRef
The Correlation Between Visceral Fat Distance Measured by Ultrasonography and Visceral Fat Amount by Computed Tomography in Type 2 Diabetes.
Eui Dal Jung, Duck Soo Chung, Ji Yun Lee
Korean Diabetes J. 2008;32(5):418-427.   Published online October 1, 2008
DOI: https://doi.org/10.4093/kdj.2008.32.5.418
  • 2,105 View
  • 22 Download
  • 4 Crossref
AbstractAbstract PDF
BACKGROUND
Visceral adipose tissue accumulation highly correlates with metabolic abnormalities and cardiovascular disease. Computed tomography (CT) is considered to be the standard method for visceral fat evaluation, but it is not used as a routine procedure. Ultrasonography (US) is a safe method, fairly inexpensive and widely available modality for measuring abdominal fat thickness. The aim of this study was to investigate the correlation between the intra-abdominal fat distance by US measurement and the visceral fat amount by CT and cardiovascular risk factors and to evaluate whether the intra-abdominal fat distance is better correlate with visceral fat amount by CT than other anthropometric parameters and to assess the cut-off value of intra-abdominal fat distance for visceral obesity in type 2 diabetic patients. METHODS: We obtained abdominal subcutaneous and intra-abdominal fat distance by using a high-resolution US (HDI 5000, ATL, Phillps, USA) at 1 cm above umbilical level in one hundred twenty-eight type 2 diabetic patients. CT scan (Light Speed plus, GE, USA) for the measurement of subcutaneous and intra-abdominal visceral fat area was also performed in the supine position at the L4-5 level. Lean body mass and % body fat were measured in a bioimpedance using DSM (Direct Segmental Measurement by 8-point electrode) method (InBody 3.0, Biospace, Seoul, Korea). We measured patient's height, weight, BMI (Body mass index), waist circumference, WHR(Waist-hip ratio) and blood pressure and also measured fasting blood glucose, HbA1c and lipid profiles. RESULTS: Abdominal subcutaneous and visceral fat distance measured by US is 2.05 +/- 0.52 cm, 4.43 +/- 1.54 cm, respectively. In pearson's correlations, visceral fat distance were correlated with BMI (r = 0.681, P < 0.001), waist circumference (r = 0.661, P < 0.001), WHR (r = 0.571, P < 0.001), triglyceride (r = 0.316, P < 0.001), HDL-cholesterol (r = -0.207, P < 0.004). US-determined visceral fat distance was also correlated with visceral fat amount by CT (r = 0.674, P < 0.001) and BMI (r = 0.610, P < 0.001), waist circumference (r = 0.626, P < 0.001), WHR (r = 0.557, P < 0.001). When we used waist circumference (men: 90 cm, women: 85 cm) as parameters for visceral obesity, the cutoff value of visceral fat distance, obtained by the receiver operating characteristic curve analysis, were 4.670 cm in men, 3.695 cm in women diabetic patients. CONCLUSION: Intra-abdominal fat distance measured by US reveals strongly correlated with visceral fat area, which is determined by CT and also well correlated with anthropometric parameters and lipid profiles. We suggest that US provided a better index compared to anthropometry for the prediction of visceral obesity and could be an alternative method for CT for visceral fat determination in diabetic patients.

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  • Aspects of transthoracic echocardiography protocol in obese patients
    O. N. Dzhioeva, O. A. Maksimova, E. A. Rogozhkina, O. M. Drapkina
    Russian Journal of Cardiology.2023; 27(12): 5243.     CrossRef
  • Ultrasound-assisted assessment of visceral and subcutaneous adipose tissue thickness. Methodological guidelines
    O. M. Drapkina, R. K. Angarsky, E. A. Rogozhkina, O. A. Maksimova, A. A. Ivanova, E. V. Zyatenkova, O. N. Dzhioeva
    Cardiovascular Therapy and Prevention.2023; 22(3): 3552.     CrossRef
  • The Correlations between Extremity Circumferences with Total and Regional Amounts of Skeletal Muscle and Muscle Strength in Obese Women with Type 2 Diabetes
    Hwi Ryun Kwon, Kyung Ah Han, Hee Jung Ahn, Jae Hyuk Lee, Gang Seo Park, Kyung Wan Min
    Diabetes & Metabolism Journal.2011; 35(4): 374.     CrossRef
  • Small Rice Bowl-Based Meal Plan versus Food Exchange-Based Meal Plan for Weight, Glucose and Lipid Control in Obese Type 2 Diabetic Patients
    Hee-Jung Ahn, Kyung-Ah Han, Hwi-Ryun Kwon, Bo-Kyung Koo, Hyun-Jin Kim, Kang-Seo Park, Kyung-Wan Min
    Korean Diabetes Journal.2010; 34(2): 86.     CrossRef
The Classification of Diabetic Patients Presenting Diabetic Ketoacidosis: The Characteristics of Fulminant Type 1 Diabetes.
Eun Hee Jang, Jeong Eun Yi, Seung Jae Lee, Sang Hoon Chun, Ki Hyun Baek, Ki Ho Song, Soon Jib Yoo, Jong Min Lee, Kun Ho Yoon, Moo Il Kang, Kwang Woo Lee, Mee Kyung Kim
Korean Diabetes J. 2008;32(5):428-434.   Published online October 1, 2008
DOI: https://doi.org/10.4093/kdj.2008.32.5.428
  • 2,731 View
  • 44 Download
  • 2 Crossref
AbstractAbstract PDF
BACKGROUND
The aim of the study was to classify newly diagnosed diabetic patients who initially presented with diabetic ketoacidosis (DKA) into specific types of diabetes and to describe the clinical and biochemical characteristics of patients with fulminant type 1 DM in Korea. METHODS: Using data from 4 hospitals of CMC from 1 January 1999 to 1 March 2008, we identified all patients who manifested DKA when they were first diagnosed as diabetes. Clinical and laboratory data were reviewed from medical records. RESULTS: We identified 51 newly diagnosed diabetic patients manifested DKA. Among them, 14 (27.4%) patients were classified as autoimmune type 1 DM, 8 (15.7%) as antibody negative type 1 DM, 5 (9.8%) as fulminant type 1, 16 (31.4%) as type 2 DM and 8 (15.7%) as secondary DM. Five patients who fulfilled the criteria of fulminant type 1 DM were older (32.2 +/- 10.7 vs. 15.7 +/- 4.4 years, P = 0.010), had shorter duration of symptoms (4.2 +/- 2.7 vs.16.7 +/- 15.2 days, P = 0.014) and lower stimulated C-peptide levels (0.1 +/- 0.0 vs. 0.7 +/- 0.6 ng/mL, P = 0.050) compared with patients with autoimmune type 1 DM. CONCLUSION Newly diagnosed diabetic patients presenting with DKA composed of heterogenous types of diabetes. The prevalence of fulminant type 1 diabetes among them was 9.8% and the clinical and biochemical characteristics of these patients were different from those of autoimmune type 1 DM.

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  • A Case of Severe Diabetic Ketoacidosis in a Child with Type 2 Diabetes
    Jaesung Yu, Hyunju Jin, Joontae Ko, Hoseok Kang
    Journal of Korean Society of Pediatric Endocrinology.2011; 16(1): 46.     CrossRef
  • A Case of Fulminant Type 1 Diabetes Mellitus Complicated with Ischemic Ileitis
    Se-Won Oh, Ju-Ri Park, Yun-Jeong Lee, Hee-Yeong Kim, Ji-A Seo, Nan-Hee Kim, Kyung-Mook Choi, Sei-Hyun Baik, Dong-Seop Choi, Sin-Gon Kim
    Journal of Korean Endocrine Society.2009; 24(2): 116.     CrossRef
Association of Hemoglobin A1c with Cardiovascular Disease Risk Factors and Metabolic Syndrome in Nondiabetic Adults.
Jin Hwa Kim, So Ra Choi, Jae Rok Lee, Ji Hye Shin, Sang Jun Lee, Mi Ah Han, Jong Park, Hak Yeon Bae, Sang Yong Kim
Korean Diabetes J. 2008;32(5):435-444.   Published online October 1, 2008
DOI: https://doi.org/10.4093/kdj.2008.32.5.435
  • 2,576 View
  • 22 Download
  • 6 Crossref
AbstractAbstract PDF
BACKGROUND
Glycosylated hemoglobin (HbA1c) is a useful index of mean blood glucose concentrations over the preceding 2 to 3 months. Elevated HbA1c levels (> 7%) are associated with a higher incidence of microvascular and macrovascular complications in patients with diabetes mellitus. However, the relationship between HbA1c and cardiovascualr disease risk in nondiabetic adults has been unclear. The aim of this study is to estimate the association of HbA1c with cardiovascular disease risk factors and metabolic syndrome in nondiabetic adults. METHODS: The subjects of this study included 533 adults (180 males and 353 females) aged 20~70 years (mean age: 46.9 +/- 10.12 years) without previously diagnosed diabetes who lived in Kangyang country. We examined baseline HbA1c levels and cardiovascular risk factors. Metabolic syndrome was defined based on International Diabetes Federation guidelines. RESULTS: The prevalence of metabolic syndrome significantly increased as HbA1c increased. HbA1c revealed a significant correlation with age (r = 0.258, P < 0.001), BMI (r = 0.152, P < 0.001), waist circumference (r = 0.252, P < 0.001), fasting plasma glucose (r = 0.319, P < 0.001), systolic (r = 0.100, P = 0.021), diastolic (r = 0.115, P = 0.008) blood pressure, total cholesterol (r = 0.232, P < 0.001), triglyceride (r = 0.156, P < 0.001), LDL cholesterol (r = 0.216, P < 0.001), and HDL cholesterol (r = -0.167, P < 0.001). Multiple regression analysis showed that HbA1c had a association with age, fasting plasma glucose, and dyslipidemia. The receiver operating characterstics (ROC) curve analysis determined HbA1c of 5.35% to yield optimal sensitivity and specificity corresponding to the presence of metabolic syndrome. CONCLUSION: The HbA1c level is correlated with cardiovascular risk factors and prevalence of metabolic syndrome in nondiabetic adults.

Citations

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  • Association of Glycated Proteins with Inflammatory Proteins and Periodontal Disease Parameters
    Jeneen Panezai, Mohammad Altamash, Per-Erik Engstrӧm, Anders Larsson
    Journal of Diabetes Research.2020; 2020: 1.     CrossRef
  • The Impact of Health Behaviors of Male Workers without Diabetes on HbA1c
    Ji-Yun Park, Keon-Yeop Kim, Su-Jin Lee
    Journal of Health Informatics and Statistics.2018; 43(4): 344.     CrossRef
  • Impact of initial glycosylated hemoglobin level on cardiovascular outcomes in prediabetic patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention
    Donghun Shin, Jinhee Ahn, Kwang Soo Cha, Jin Sup Park, Jun-Hyok Oh, Hye-Won Lee, Ju-Yong Hong, Bo-Won Kim, Taek Jong Hong
    Coronary Artery Disease.2016; 27(1): 40.     CrossRef
  • HbA1c Levels Are Associated with Chronic Kidney Disease in a Non-Diabetic Adult Population: A Nationwide Survey (KNHANES 2011–2013)
    Seok Hui Kang, Da Jung Jung, Eun Woo Choi, Kyu Hyang Cho, Jong Won Park, Jun Young Do, Sheng-Nan Lu
    PLOS ONE.2015; 10(12): e0145827.     CrossRef
  • Usefulness of Glycated Hemoglobin as Diagnostic Criteria for Metabolic Syndrome
    Sang Hyun Park, Ji Sung Yoon, Kyu Chang Won, Hyoung Woo Lee
    Journal of Korean Medical Science.2012; 27(9): 1057.     CrossRef
  • Relationship between inflammation biomarkers, antioxidant vitamins, and bone mineral density in patients with metabolic syndrome
    Yesong Lee, Misung Kim, Kyungsuk Choi, Juyong Kim, Wookyung Bae, Sohye Kim, Cheongmin Sohn
    Nutrition Research and Practice.2011; 5(2): 150.     CrossRef
Randomized Controlled Trial
The Effect of Rosiglitazone and Metformin Therapy, as an Initial Therapy, in Patients with Type 2 Diabetes Mellitus.
Tae Seo Sohn, Jee In Lee, In Ju Kim, Kyung Wan Min, Hyun Shik Son
Korean Diabetes J. 2008;32(5):445-452.   Published online October 1, 2008
DOI: https://doi.org/10.4093/kdj.2008.32.5.445
  • 2,949 View
  • 26 Download
  • 2 Crossref
AbstractAbstract PDF
BACKGROUND
Type 2 diabetes is usually preceded by a long and clinically silent period of increasing insulin resistance. The purpose of this study is to demonstrate that rosiglitazone and metformin fixed-dose combination therapy (RSG/MET) will safely and effectively control glycemia as a first line of oral therapy, better than rosiglitazone (RSG) or metformin (MET) monotherapy in Korean type 2 diabetes patients. METHODS: This study was a 32-week, multicenter, randomized, double-blind study. Twenty-seven type 2 diabetes patients (males 14; females 13) were included and randomly divided into the rosiglitazone, metformin group, or rosiglitazone /metformin combination groups. The primary objective of this study was to determine the change in HbA1c from baseline (week 0) to week 32. The secondary end-points were to determine changes in fasting plasma glucose (FPG) and homeostasis model assessment insulin resistance (HOMA-IR), from baseline to week 32. Other cardiovascular risk markers were also assessed. RESULTS: At week 32, there were significant reductions in HbA1c and FPG, in all three treatment groups. There was no statistical difference in HbA1c among the three groups, but the decrease in FPG in the RSG/MET group was statistically significant compared to the MET group (P < 0.05). RSG/MET significantly reduced HOMA-IR at week 32 compared to baseline, but there was no difference among the three groups. RSG/MET significantly decreased high-sensitive C-reactive protein (hs-CRP) value at week 32, compared to baseline. There were increases in adiponectin from baseline to week 32 in the RSG and RSG/MET groups, and the increase in the RSG/MET group was statistically significant compared to that of the MET group (P < 0.05). At week 32, there was a significant decrease in plasminogen activator inhibitor-1 (PAI-1) in all three treatment groups, but no statistically significant difference among them. The RSG/MET group significantly decreased in terms of urinary albumin-creatinine ratio at week 32, compared to baseline. CONCLUSIONS: In this study, rosiglitazone and metformin combination therapy was effective in glycemic control as an initial therapy, and it improved cardiovascular risk markers in Korean type 2 diabetes patients.

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  • Rosiglitazone metformin adduct inhibits hepatocellular carcinoma proliferation via activation of AMPK/p21 pathway
    Yuyang Liu, Xiangnan Hu, Xuefeng Shan, Ke Chen, Hua Tang
    Cancer Cell International.2019;[Epub]     CrossRef
  • Comparison of the Efficacy of Glimepiride, Metformin, and Rosiglitazone Monotherapy in Korean Drug-Naïve Type 2 Diabetic Patients: The Practical Evidence of Antidiabetic Monotherapy Study
    Kun Ho Yoon, Jeong Ah Shin, Hyuk Sang Kwon, Seung Hwan Lee, Kyung Wan Min, Yu Bae Ahn, Soon Jib Yoo, Kyu Jeung Ahn, Sung Woo Park, Kwan Woo Lee, Yeon Ah Sung, Tae Sun Park, Min Seon Kim, Yong Ki Kim, Moon Suk Nam, Hye Soon Kim, Ie Byung Park, Jong Suk Par
    Diabetes & Metabolism Journal.2011; 35(1): 26.     CrossRef
Original Article
Effects of Comprehensive Support on Glycemic Control Using Community Networks in Low- Income Elderly Patients with Diabetes.
Nam Hoon Kim, Yun Jeong Lee, Hye Ok Kim, Cho Rong Oh, Ju Ri Park, Soo Yoen Park, Hee Young Kim, Ji A Seo, Nan Hee Kim, Kyung Mook Choi, Sei Hyun Baik, Dong Seop Choi, Sin Gon Kim
Korean Diabetes J. 2008;32(5):453-461.   Published online October 1, 2008
DOI: https://doi.org/10.4093/kdj.2008.32.5.453
  • 2,356 View
  • 29 Download
  • 7 Crossref
AbstractAbstract PDF
BACKGROUND
Diabetes is common among elderly, and low-income is associated with poor adherence to treatment and increased mortality. We evaluated whether comprehensive support using community networks improves glycemic control among low-income elderly patients with diabetes. METHODS: A total of 49 low-income elderly patients with type 2 diabetes, mean age 73 years, were enrolled. For 1 year, study subjects underwent various lifestyle modification programs provided by community networks. The biochemical data including glycemic markers and anthropometric data were obtained at the baseline and at the end of the study. Also, the patients were asked to complete a questionnaire about their quality of life, self-confidence and self-care behavior. RESULTS: After lifestyle modification program, overall changes of fasting plasma glucose, HbA1c, blood pressure, body weight, and other biochemical markers were not significantly different. In a subgroup analysis of 21 patients with poorly controlled diabetes (fasting glucose > 140 mg/dL or HbA1c > 7.5%), fasting plasma glucose was significantly reduced (P = 0.030). Among patients with baseline HbA1c level > or = 8%, HbA1c levels after intervention decreased from 9.33 +/- 1.07% to 8.27 +/- 1.15% (P = 0.092). The results of the questionnaires revealed significant increases in the scores of quality of life, self-confidence and self-care behavior (P < 0.05). CONCLUSION: Among low-income, elderly patients with type 2 diabetes, lifestyle modification through community networks showed no significant changes in glycemic control markers. More intensive and precise interventions using community networks are needed for the glycemic control of low-income, elderly patients with type 2 diabetes.

Citations

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  • The Effects of a Health Mentoring Program in Community-dwelling Vulnerable Elderly Individuals with Diabetes
    Ki wol Sung, Hye Seung Kang, Ji Ran Nam, Mi Kyung Park, Ji Hyeon Park
    Journal of Korean Academy of Nursing.2018; 48(2): 182.     CrossRef
  • Development of a scale to measure diabetes self‐management behaviors among older Koreans with type 2 diabetes, based on the seven domains identified by the American Association of Diabetes Educators
    Kyoungsan Seo, Misoon Song, Suyoung Choi, Se‐an Kim, Sun Ju Chang
    Japan Journal of Nursing Science.2017; 14(2): 161.     CrossRef
  • Current Status and Effects of Dining with Diabetes in Korea and Abroad
    Seung Hye Yang
    The Journal of Korean Diabetes.2017; 18(2): 117.     CrossRef
  • Diabetes Management through Care Communities
    Kyeong Ok Yun
    The Journal of Korean Diabetes.2016; 17(4): 271.     CrossRef
  • Understanding Psycho-Social Aspects and Social Welfare Information of Low-Income Diabetes Patients
    Been Yoo
    The Journal of Korean Diabetes.2015; 16(3): 212.     CrossRef
  • Newly Diagnosed Diabetes Mellitus With Pancreatic Cancer Manifested as Hyperglycemic Hyperosmolar State
    Tae Hyung Kwon, Min Seong Kim, Jun Ho Jeon, Dong Il Jeong, Sang Seok Yun, Yong Kyu Lee
    Journal of the Korean Geriatrics Society.2013; 17(2): 95.     CrossRef
  • Development of a Comprehensive Self-Management Program Promoting Self Efficacy for Type 2 Diabetic Patients
    Ju-Young Park, Il-Sun Ko
    Journal of Korean Academy of Fundamentals of Nursing.2012; 19(1): 74.     CrossRef
Letters
Relationship Between Serum Bilirubin Levels and Coronary Atherosclerosis in Patients with Type 2 Diabetes.
Soo Lim
Korean Diabetes J. 2008;32(5):462-463.   Published online October 1, 2008
DOI: https://doi.org/10.4093/kdj.2008.32.5.462
  • 1,962 View
  • 17 Download
AbstractAbstract PDF
No abstract available.
Relationship Between Serum Bilirubin Levels and Coronary Atherosclerosis in Patients with Type 2 Diabetes.
Jun Sung Moon, Kyu Chang Won
Korean Diabetes J. 2008;32(5):464-466.   Published online October 1, 2008
DOI: https://doi.org/10.4093/kdj.2008.32.5.464
  • 2,094 View
  • 18 Download
AbstractAbstract PDF
No abstract available.

Diabetes Metab J : Diabetes & Metabolism Journal