Table 1Characteristics of patients
Characteristic |
TT/TC (n=120) |
CC (n=60) |
P value |
Lipid lowering medications |
|
|
|
Without medications |
62 (51.7) |
22 (36.7) |
|
Atorvastatin |
49 (40.8) |
32 (53.3) |
0.17a
|
Simvastatin |
4 (3.3) |
1 (1.7) |
|
Gemfibrozil |
5 (4.2) |
5 (8.3) |
|
Antidiabetic agents |
|
|
|
Without medications |
8 (6.7) |
5 (8.3) |
|
Metformin |
42 (35.0) |
21 (35.0) |
0.98a
|
Glibenclamide |
6 (5.0) |
3 (5.0) |
|
Metformin+Glibenclamide |
64 (53.3) |
31 (51.7) |
|
Age, yr |
52.98±6.80 |
56.00±5.89 |
0.004b
|
BMI, kg/m2
|
29.59±4.63 |
29.35±4.24 |
0.74b
|
WC, cm |
92.57±10.96 |
91.73±10.39 |
0.62b
|
Physical activity, MET, time/day |
38.91±5.92 |
37.44±4.39 |
0.08b
|
Food intake |
|
|
|
Energy, kcal/day |
2,524.80±815.66 |
2,646.87±1,056.31 |
0.43b
|
Carbohydrate, g/day |
334.87±115.35 |
358.42±174.42 |
0.48c
|
Protein, g/day |
88.10±27.28 |
90.77±38.24 |
0.74c
|
Fat, g/day |
100.75±44.23 |
104.16±51.20 |
0.70c
|
Polyunsaturated fatty acid, g/day |
23.95±12.86 |
26.15±16.50 |
0.60c
|
Monounsaturated fatty acid, g/day |
34.56±17.12 |
35.04±18.35 |
0.49c
|
Saturated fatty acid, g/day |
26.98±10.71 |
25.86±9.67 |
0.06c
|
Lipid profile |
|
|
|
Triglycerides, mmol/L |
2.12±1.36 |
1.88±1.24 |
0.25b
|
Total cholesterol, mmol/L |
5.17±1.90 |
4.99±2.57 |
0.59b
|
HDL-C, mmol/L |
1.36±0.29 |
1.41±0.36 |
0.45b
|
LDL-C, mmol/L |
2.86±1.00 |
2.81±0.95 |
0.73b
|
Table 2Comparison of inflammatory markers between T allele carriers and CC genotype in total study population and separately in obese and non-obese patients
Variable |
IL-18, pg/mL |
PTX3, ng/mL |
hs-CRP, mg/L |
TT+TC (n=120) |
248.41±32.33 |
2.68±0.46 |
1.92±1.34 |
CC (n=60) |
251.10±27.50 |
2.51±0.45 |
2.83±1.65 |
Mean difference (95% CI) |
2.33 (-7.23 to 11.90) |
-0.16 (-0.30 to -0.02) |
0.91 (0.46 to 1.36) |
P valuea
|
0.63 |
0.02 |
<0.001 |
P valueb
|
0.54 |
0.01 |
0.001 |
Obese (n=90) |
|
|
|
TT+TC |
254.14±35.64 |
2.59±0.38 |
2.28±1.22 |
CC |
256.89±28.49 |
2.44±0.51 |
3.04±1.61 |
Mean difference (95% CI) |
1.44 (-13.27 to 16.15) |
-0.15 (-0.34 to 0.03) |
0.77 (0.17 to 1.37) |
P valuea
|
0.84 |
0.02 |
0.014 |
P valuec
|
0.91 |
0.03 |
0.008 |
Non-obese (n=90) |
|
|
|
TT+TC |
242.37±27.69 |
2.76±0.52 |
1.55±1.37 |
CC |
245.31±25.79 |
2.59±0.37 |
2.59±1.69 |
Mean difference (95% CI) |
2.94 (-9.08 to 14.98) |
-0.17 (-0.38 to 0.04) |
1.03 (0.37 to 1.69) |
P valuea
|
0.62 |
0.04 |
0.002 |
P valuec
|
0.88 |
0.04 |
0.01 |
Table 3Comparison of mean inflammatory markers between obese and non-obese patients in T allele carriers and CC genotype
Variable |
IL-18, pg/mL |
PTX3, ng/mL |
hs-CRP, mg/L |
TT+TC (n=120) |
|
|
|
Obese |
254.56±35.64 |
2.59±0.38 |
2.28±1.22 |
Non-obese |
242.37±27.69 |
2.76±0.52 |
1.55±1.37 |
Mean difference (95% CI) |
-12.19 (-23.77 to -0.61) |
0.17 (0.003 to 0.33) |
-0.72 (-1.19 to -0.25) |
P valuea
|
0.03 |
0.04 |
0.003 |
P valueb
|
0.12 |
0.50 |
0.01 |
CC (n=60) |
|
|
|
Obese |
256.31±25.79 |
2.44±0.51 |
3.06±1.61 |
Non-obese |
245.10±28.49 |
2.59±0.37 |
2.59±1.69 |
Mean difference (95% CI) |
-10.68 (-24.63 to 3.25) |
0.15 (-0.07 to 0.38) |
-0.46 (-1.31 to 0.38) |
P valuea
|
0.13 |
0.19 |
0.27 |
P valueb
|
0.41 |
0.53 |
0.29 |