Serum Prolactin and Cardiac Remodeling in Subjects with Prediabetes

Article information

Diabetes Metab J. 2017;41(3):168-169

Publication date (electronic) : 2017 June 21

doi : https://doi.org/10.4093/dmj.2017.41.3.168

Department of Endocrinology and Metabolism, Chosun University Hospital, Chosun University College of Medicine, Gwangju, Korea.

Corresponding author: Jin Hwa Kim. Department of Endocrinology and Metabolism, Chosun University Hospital, Chosun University College of Medicine, 365 Pilmun-daero, Dong-gu, Gwangju 61453, Korea. endocrine@chosun.ac.kr

Prolactin is an anterior pituitary hormone, and its most well-known physiological role is to control initiation and maintenance of lactation [1]. Recently, its other broad physiological functions including metabolism were suggested, as the expression of prolactin receptor was found in various organs such as endometrium, prostate, pancreatic islets, and adipose tissue [2 3]. Previous studies showed that prolactin has effects on obesity, insulin resistance, and the growth of pancreatic β-cells, which may mediate diabetes [1 4 5]. Several studies suggested an inverse association between serum prolactin levels and metabolic parameters such as cardiovascular events, cardiac remodeling, diabetes, metabolic syndrome, and adverse lipid profiles [6 7 8]. Furthermore, studies on serum prolactin levels within the physiological range revealed conflicting results.

This article entitled “Impact of gender on the association between low serum prolactin and left ventricular mass in subjects with prediabetes,” along with that published by El-Eshmawy et al. [9], evaluated the association between serum prolactin level and cardiac remodeling in patients with prediabetes according to gender. It is helpful that the association between serum prolactin levels and other parameters were evaluated separately for each gender, as serum prolactin levels can be regulated differently between genders. Estrogen is believed to play a central role in the control of prolactin release. In this study, physiologically low serum prolactin was an independent predictor of increased left ventricular mass and left ventricular hypertrophy in adult men, but not in women. Determining the exact biologic mechanism underlying these differences was not possible because it was a cross sectional study. However, this approach is quite valuable in establishing a potential gender-specific diagnostic biomarker for cardiac remodeling in patients with prediabetes. The authors have clearly shown their results in this manuscript.

In my opinion, it would have added more value to their findings if they measured and adjusted for the effect of sex hormones and sex hormone-binding globulins as a potential confounding factors, which would have demonstrated the results more clearly.

Notes

CONFLICTS OF INTEREST: No potential conflict of interest relevant to this article was reported.

References

1. Ben-Jonathan N, LaPensee CR, LaPensee EW. What can we learn from rodents about prolactin in humans? Endocr Rev 2008;29:1–41. 18057139.

2. Brandebourg T, Hugo E, Ben-Jonathan N. Adipocyte prolactin: regulation of release and putative functions. Diabetes Obes Metab 2007;9:464–476. 17587388.

3. Freemark M, Driscoll P, Maaskant R, Petryk A, Kelly PA. Ontogenesis of prolactin receptors in the human fetus in early gestation. Implications for tissue differentiation and development. J Clin Invest 1997;99:1107–1117. 9062370.

4. Sauve D, Woodside B. Neuroanatomical specificity of prolactin-induced hyperphagia in virgin female rats. Brain Res 2000;868:306–314. 10854583.

5. Nilsson L, Binart N, Bohlooly YM, Bramnert M, Egecioglu E, Kindblom J, Kelly PA, Kopchick JJ, Ormandy CJ, Ling C, Billig H. Prolactin and growth hormone regulate adiponectin secretion and receptor expression in adipose tissue. Biochem Biophys Res Commun 2005;331:1120–1126. 15882993.

6. Haring R, Volzke H, Vasan RS, Felix SB, Nauck M, Dorr M, Wallaschofski H. Sex-specific associations of serum prolactin concentrations with cardiac remodeling: longitudinal results from the Study of Health Pomerania (SHIP). Atherosclerosis 2012;221:570–576. 22293228.

7. Balbach L, Wallaschofski H, Volzke H, Nauck M, Dorr M, Haring R. Serum prolactin concentrations as risk factor of metabolic syndrome or type 2 diabetes? BMC Endocr Disord 2013;13:12. 23517652.

8. Wang T, Lu J, Xu Y, Li M, Sun J, Zhang J, Xu B, Xu M, Chen Y, Bi Y, Wang W, Ning G. Circulating prolactin associates with diabetes and impaired glucose regulation: a population-based study. Diabetes Care 2013;36:1974–1980. 23340889.

9. El-Eshmawy MM, Elkhamisy EM, Elsayed E, Kamal S. Impact of gender on the association between low serum prolactin and left ventricular mass in subjects with prediabetes. Diabetes Metab J 2017;41:195–204.

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