Effects of Pioglitazone on Cerebral Hemodynamics in Patients of Type 2 Diabetes.

Park,  Jong Suk; Lee,  You Jung; Kim,  Chul Sik; Kim,  Hai Jin; Park,  Jina; Ahn,  Chul Woo; Lee,  Kyung Yul; Kim,  Hyeong Jin; Won,  Young Jun; Ha,  Hun Ju; Kwak,  Hae Sun; Cha,  Bong Soo; Lim,  Sung Kil; Kim,  Kyung Rae; Lee,  Hyun Chul

doi:2006.30.2.96

Diabetes Metab J > Volume 30(2); 2006 > Article

Original Article

Korean Diabetes Journal 2006;30(2):96-103.
DOI: https://doi.org/10.4093/jkda.2006.30.2.96 Published online March 1, 2006.

Effects of Pioglitazone on Cerebral Hemodynamics in Patients of Type 2 Diabetes.

Jong Suk Park, You Jung Lee, Chul Sik Kim, Hai Jin Kim, Jina Park, Chul Woo Ahn, Kyung Yul Lee, Hyeong Jin Kim, Young Jun Won, Hun Ju Ha, Hae Sun Kwak, Bong Soo Cha, Sung Kil Lim, Kyung Rae Kim, Hyun Chul Lee

¹Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
²Ewha Graduate School of Clinical Health Science, Seoul, Korea.
³Department of Neurology, Yonsei University College of Medicine, Seoul, Korea.
⁴Department of Internal Medicine, Kwandong University College of Medicine, Gangneung, Korea.

Abstract

BACKGROUND
Atherosclerosis is one of the major causes of morbidity and mortality in patients with type 2 diabetes and pioglitazone has been reported to have antiatherogenic effect. The aim of this study was to investigate whether pioglitazone affects carotid intima-media thickness (IMT) and pulsatility index (PI) in type 2 diabetic patients. METHODS: A total of 40 type 2 diabetic patients were included and divided into two groups: the pioglitazone-treated group (pioglitazone 15 mg/day with gliclazide 80~320 mg/day for 12 weeks) (n = 20) and control group (gliclazide 80~320 mg/day for 12 weeks) (n = 20). The changes in lipid profile, insulin resistance, IMT, and PI were monitored to determine that pioglitazone improves cerebrovascular blood flow. RESULTS: The pioglitazone treatment significantly increased HDL-C, reduced triglyceride, insulin resistance and PI. IMT tended to decrease but the change was not significant. This study revealed that treatment with pioglitazone was associated with the improvement of cerebrovascular blood flow. CONCLUSIONS: Pioglitazone appears to be effective for the improvement of cerebrovascular blood flow in type 2 diabetic patients

Key Words: IMT (intima-media thickness), PI (pulsatility index), Pioglitazone, Type 2 diabetes