Diabetes Metab J > Volume 30(6); 2006 > Article
Korean Diabetes Journal 2006;30(6):459-465.
DOI: https://doi.org/10.4093/jkda.2006.30.6.459    Published online November 1, 2006.
Effect of Sea Tangle Powder on the Regulation of Blood Glucose Level and Body Weight in Streptozotocin (STZ)-induced Diabetic Rats.
Hyung Woo Kim, Jae Seung Kang, Su In Kim, Wang Jae Lee
1Department of Anatomy and Tumor Immunity Medical Research Center, Seoul National University, College of Medicine, Korea.
2EntoPharm Co., Ltd, Korea.
Abstract
BACKGROUND
Sea tangle is one of the low calorie diet and the fibers in sea tangle suppress the increase of blood glucose level. Therefore, it has a better impact than any other diets for diabetic patients. In the present study, we have investigated the effect of sea tangle powder, hereafter referred as Substance , as an antihyperglycemic agent and antioxidant in streptozotocin (STZ)-induced diabetic rats. METHODS: Male Wistar rats were divided into three groups: group 1) vehicle-treated normal rats; group 2) vehicle-treated STZ-diabetic rats; group 3) sea tangle powder-treated STZ-diabetic rats. Fasting blood glucose levels and body weights were measured. Intracellular ROS levels were measured using Cytofluor 2350 plate reader. RESULTS: Oral administration of sea tangle powder for 10 days resulted in lowered levels of blood glucose in early stage (within a week) and preventing effect of weight loss in late stage. Treatment with sea tangle powder resulted in the decrease of intracellular ROS levels in Dendritic Cell line. CONCLUSION: Sea tangle powder exhibits antihyperglycemic activity and restorative activity on weight loss in STZ-induced diabetic rats. It's abilities depend not on protecting disruption of beta-cell, but on antioxidant effect in other organs.
Key Words: Antioxidant, Diabetes mellitus, Sea tangle powder


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