Diabetes Metab J > Volume 31(1); 2007 > Article
Korean Diabetes Journal 2007;31(1):1-8.
DOI: https://doi.org/10.4093/jkda.2007.31.1.1    Published online January 1, 2007.
The Roles of Clusterin on Morphogenesis of Beta Cells During Pancreas Regeneration.
Seok Woo Hong, KC Ranjan, Song Lee, Yong Jae Shin, Bon Hong Min, In Sun Park
1Department of Anatomy and Center for Advanced Medical Education by BK21 project1, College of Medicine, Inha University, Korea.
2Department of Pharmacology & BK21 program for Medical Sciences2, College of Medicine, Korea University, Korea.
Abstract
Clusterin is a highly glycosylated heterodimeric glycoprotein that plays diverse biological roles in various organs. The secreted clusterin has been established as a major form of the protein that exerts diverse tissue effects. For instance, clusterin is known to act in cell protection through the actions of extra-cellular molecular chaperones. In the extracellular milieu, clusterin participates in specific interactions with a diverse array of native biological molecules including LRP-2 (Lipoprotein receptor-related protein 2, also known as gp330 or megalin), which is involved in ligand endocytosis at the surfaces of certain epithelia. Clusterin is expressed transiently in developing and differentiating endocrine pancreatic cells and might be involved in pancreas development. This transient expression of clusterin at specific time points of pancreas development and cell differentiation during pancreas regeneration implies that the protein is a regulatory factor for cytodifferentiation as well as for replication. A specific action of the clusterin in the reconstruction and remodeling of the endocrine pancreas has been demonstrated. It also strongly stimulates duct cell differentiation into insulin-secreting cells under in vitro culture conditions. Clusterin appears thus as a potent regulator of insulin cell morphogenesis.
Key Words: Beta cells, Clusterin, Development, Differentiation, Duct cells, Insulin, Regeneration


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