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Case Report A Case of Fulminant Type 1 Diabetes Associated with Pregnancy.
Hyung Kwon Yu, Moonsuk Nam, Wan Sub Shim, Hyun Jung Chung, Eun Joo Kim, Seong Bin Hong, Yong Seong Kim
Diabetes & Metabolism Journal 2007;31(2):180-183
Published online: March 1, 2007
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Inha University Hospital, Department Of Internal Medicine, Division Of Endocrinology and Metabolism, Korea.

Type 1 diabetes is characterized by insulin deficiency due to destruction of pancreatic beta-cells. A novel subtype of type 1B which is rapidly developed without any evidence of autoimmunity has been recently proposed as fulminant type I diabetes. In female patients of child-bearing age, the onset of fulminant type 1 diabetes occurred frequently during pregnancy or after delivery in Japan, however, there was no report about fulminant type 1 diabetes associated with pregnancy in Korea. We report a case of fulminant type 1 diabetes associated with pregnancy. A 28-year-old woman suffering from excessive thirst with vomiting and general weakness after four days from normal spontaneous vaginal delivery presented to our hospital. Laboratory examination revealed a high blood glucose level and evidence of diabetic ketoacidosis, butHbA1c level was normal. These findings suggested a very recent onset of diabetes mellitus. Serum C-peptide level was very low level. Antibodies to glutamic acid decarboxylase (GAD) was weakly positive. After fluid and insulin based management, patient successfully recovered without any serious complication.

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    A Case of Fulminant Type 1 Diabetes Associated with Pregnancy.
    Korean Diabetes J. 2007;31(2):180-183.   Published online March 1, 2007
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