Diabetes Metab J > Volume 31(3); 2007 > Article
Korean Diabetes Journal 2007;31(3):187-192.
DOI: https://doi.org/10.4093/jkda.2007.31.3.187    Published online May 1, 2007.
Mitochondrial Gene Therapy.
Kyung Soo Ko
Mitochondrial Research Group, Department of Internal Medicine, College of Medicine, Inje University, Korea.
Abstract
Mitochondrial dysfunction contributes to a large variety of human disorders, ranging from neurodegenerative and neuromuscular diseases, obesity, and diabetes to ischemia-reperfusion injury and cancer. Increasing pharmacological efforts toward therapeutic interventions have been made leading to the emergence of 'Mitochondrial Medicine' as a new field of biomedical research. The identification of molecular mitochondrial drugs targets in combination with the development of methods for selectively delivering biologically active molecules to the site of mitochondria will eventually launch a multitude of new therapies for the treatment of mitochondria-related diseases, which are based either on the selective protection, repair, or eradication of cells. Yet, while tremendous efforts are being undertaken to identify new mitochondrial drugs and drug targets, the development of mitochondria-specific drug carrier systems is lagging behind. To ensure a high efficiency of current and future mitochondrial therapeutics, delivery systems need to be developed, which are able to selectively transport biologically active molecules to and into mitochondria within living cells.
Key Words: DNA delivery, gene carrier, Mitochondria, Mitochondrial leader peptide
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