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HOME > Diabetes Metab J > Volume 31(4); 2007 > Article
Case Report Two Cases of Autoantibody Negative Fulminant Type 1 Diabetes Mellitus.
Hwa Young Cho, Young Min Cho, Myoung Hee Park, Mi Yeon Kang, Ki Hwan Kim, Yun Hyi Ku, Eun Kyung Lee, Do Joon Park, Chan Soo Shin, Kyong Soo Park, Seong Yeon Kim, Bo Youn Cho, Hong Kyu Lee
Diabetes & Metabolism Journal 2007;31(4):372-376
DOI: https://doi.org/10.4093/jkda.2007.31.4.372
Published online: July 1, 2007
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1Department of Internal Medicine, Seoul National University College of Medicine.
2Department of Laboratory Medicine, Seoul National University College of Medicine.

Autoantibody negative fulminant type 1 diabetes mellitus is a novel subtype of type 1 diabetes, which is characterized by a remarkably abrupt onset, metabolic derangement such as diabetic ketoacidosis at diagnosis, low HbA1c level at onset and a negative islet-related autoantibodies. The prevalence of fulminant type 1 diabetes has large difference between Japan and other countries. The precise reason for this regional variation remains to be clarified. One of the possible explanations is genetic background such as genotype of class II HLA molecule. In addition, environment factors including viral infection are suggested as possible pathogenesis of the disease. Only a few cases with fulminant type 1 diabetes have been reported outside Japan, and most of these cases with definite diagnosis have been reported in Korea. We report here on two Korean patients that met the criteria for diagnosis of fulminant type 1 diabetes in accordance with their HLA genotypes.

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    Two Cases of Autoantibody Negative Fulminant Type 1 Diabetes Mellitus.
    Korean Diabetes J. 2007;31(4):372-376.   Published online July 1, 2007
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