Skip Navigation
Skip to contents

Diabetes Metab J : Diabetes & Metabolism Journal



Page Path
HOME > Diabetes Metab J > Volume 40(4); 2016 > Article
Original Article
Complications Prevalence and Risk Factors of Gastroesophageal Reflux Disease in Patients with Type 2 Diabetes Mellitus
Jun Ouk Ha1, Tae Hee Lee2, Chang Won Lee1orcid, Ja Young Park1, Seong Ho Choi1, Hee Seung Park1, Jae Seung Lee1, Seung Heon Lee1, Eun Hee Seo1, Young Hwan Kim1, Young Woo Kang2
Diabetes & Metabolism Journal 2016;40(4):297-307.
Published online: June 8, 2016
  • 55 Download
  • 8 Web of Science
  • 9 Crossref
  • 9 Scopus

1Department of Internal Medicine, Busan St. Mary's Hospital, Busan, Korea.

2Department of Internal Medicine, Konyang University College of Medicine, Daejeon, Korea.

Corresponding author: Chang Won Lee. Department of Internal Medicine, Busan St. Mary's Hospital, 25-14 Yonghoro 232beon-gil, Nam-gu, Busan 48575, Korea.
*Jun Ouk Ha and Tae Hee Lee contributed equally to this study as first authors.
• Received: July 31, 2015   • Accepted: October 19, 2015

Copyright © 2016 Korean Diabetes Association

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

  • Background
    Gastrointestinal symptoms are common in patients with type 2 diabetes mellitus (T2DM). The prevalence of gastroesophageal reflux disease (GERD) in Korea appears to be increasing. Some studies have shown that T2DM is a risk factor for symptomatic GERD. However, this possibility is still debated, and the pathogenesis of GERD in T2DM is not yet fully understood. The aim of this study was to analyze the prevalence and risk factors (including autonomic neuropathy) of GERD in patients with T2DM.
  • Methods
    This cross-sectional case-control study enrolled T2DM patients (n=258) and healthy controls (n=184). All participants underwent physical examinations and laboratory tests. We evaluated medical records and long-term diabetes complications, including peripheral and autonomic neuropathy in patients with T2DM. Esophagogastroduodenoscopy was performed in all patients. The Los Angeles (LA) classification was used to grade GERD. GERD was defined as LA grade A (or higher) or minimal change with GERD symptoms. GERD symptoms were examined using a frequency scale. Data were expressed as mean±standard error. Independent t-tests or chi-square tests were used to make comparisons between groups.
  • Results
    The prevalence of GERD (32.6% vs. 35.9%, P=0.266) and GERD symptoms (58.8% vs. 59.2%, P=0.503) was not significantly different between T2DM patients and controls. We found no significant differences between T2DM patients with GERD and T2DM patients without GERD with respect to diabetic complications, including autonomic neuropathy, peripheral neuropathy, duration of DM, and glucose control.
  • Conclusion
    The prevalence of GERD in patients with T2DM showed no difference from that of controls. GERD was also not associated with peripheral and cardiovascular autonomic neuropathy, age, or duration of DM in patients with T2DM.
Gastrointestinal (GI) symptoms are common in patients with type 2 diabetes mellitus (T2DM) [1]. These symptoms can influence the patient's health-related quality of life and affect dietary habits, productivity, and employment status [23]. The prevalence of gastroesophageal reflux disease (GERD) is reported as 10% to 20% in Western countries [45], whereas Asian countries have a lower prevalence. However, recent studies have shown that the prevalence of GERD is increasing in Asia [46]. A Korean study reported a prevalence of 18% for erosive esophagitis among patients with diabetes mellitus (DM) who underwent esophagogastroduodenoscopy (EGD) due to various GI symptoms [7].
An association is suspected between GI symptoms and DM complications (autonomic neuropathy, peripheral neuropathy, and microvascular complications) and poor glycemic control in patients with DM [8910]. Some studies have shown that T2DM is a risk factor for symptomatic GERD [11], and a higher prevalence (28%) of abnormal GE reflux appeared among asymptomatic diabetic patients than among the general population [12]. However, this relationship is still debated, and the pathogenesis of GERD in T2DM is not yet fully understood.
The aim of this study was to analyze the prevalence and risk factors (including peripheral and cardiovascular autonomic neuropathy) of GERD in Korean patients with T2DM.
Study population
This study received the approval of the Clinical Ethics Committee (BSM 2010-03). The research subjects included patients with T2DM and a healthy control group, all over 40 years of age, who received a general checkup (including public corporation checkup) during the period between March 2010 and December 2010 and who provided informed consent for data usage.
Exclusion criteria included stomach or esophagus diseases found by endoscopy during the previous 6 months, current treatment with a gastric acid blocker, cardiovascular diseases or severe heart diseases (hospitalization due to cardiac infarction, stroke, or heart failure during the previous 3 months), renal diseases (creatinine over 2.0 mg/dL), type 1 diabetes, and failure to acquire consent. This study was designed by the division of endocrinology and metabolism at Busan St. Mary's Hospital, and informed consent was received by the Division of Endocrinology and Metabolism and other departments (the Health Examination Center, etc.). Due to a lack of active cooperation with other departments, the number of control group patients who provided informed consent was less than that of patients with T2DM, and this threshold resulted in a discrepancy of age and gender, etc., between T2DM patients and control group patients.
Study protocol
General anthropometry items (height, weight, waist measurement, and blood pressure), smoking and alcohol consumption history, and past and current medical histories were examined for all subjects. The subjects fasted for 8 hours and underwent blood tests in a public corporation checkup (fasting blood glucose, lipid profile, aspartate aminotransferase [AST], alanine aminotransferase [ALT], gamma-glutamyltranspeptidase (γ-GTP), and creatinine) and an upper GI endoscopy. The diabetes patients were also assessed for diabetes duration, glycosylated hemoglobin (HbA1c), complications (autonomic nerve disorder, peripheral nerve disorder, macrovascular complications, peripheral arteriosclerosis, diabetic retinopathy, and diabetic nephropathy), and any current medications.

Diagnosis of gastroesophageal reflux disease

All patients underwent an EGD. All study procedures were performed by five expert endoscopists who had each more than 1,000 endoscopies per year. The experts looked for esophageal mucosal breaks. Reflux esophagitis was graded using the Los Angeles (LA) classification (Supplementary Table 1) [13]. Later, endoscopists were asked to decode the pictures, and the differences are shown in Table 1. In this study, the interobserver reliability of the endoscope result was included in substantial agreement (κ=0.703, P<0.001).
All patients completed a frequency scale for symptoms of GERD (FSSG) questionnaire to assess GERD symptoms. The FSSG consisted of 12 questions, scored to indicate the frequency of symptoms as follows: never, 0; occasionally, 1; sometimes, 2; often, 3; and always, 4. Patients with FSSG scores of more than 8 were considered positive for GERD. When the cut-off score is set at 8 points, this test shows a sensitivity of 62%, a specificity of 59%, and an accuracy of 60% (Supplementary Table 2) [14]. In this study, GERD was diagnosed when a patient had erosive esophagitis or nonerosive esophagitis with an FSSG score ≥8 and minimal change.

Measurement of brachial-ankle pulse wave velocity

Brachial-ankle pulse wave velocity (baPWV) measurements were performed using our previously published method [15]. Left and right baPWVs were measured, and the largest value was defined as the maximum baPWV (max-baPWV) [15].

Diagnosis of cardiovascular autonomic neuropathy

The cardiovascular autonomic nervous function test was conducted using the DiCAN method (Medicore, Seoul, Korea), which was similar to the method used in our previous research [16]. Measurements included the heart rate change during a Valsalva maneuver, posture change, and repetitive exhalation and inhalation, as well as the blood pressure change during standing and grasping power injection. The scores for these five items were 0 for normal, 0.5 for borderline anomaly, and 1 for anomaly, where a score of 5 was defined as the maximum value. Any case with a total score over 1.5 was defined as having a cardiovascular autonomic nervous disease [16].

Diagnosis of peripheral neuropathy

All neurologic examinations were performed using our previously published algorithms [15]. The total symptom score (TSS) was based on the severity and frequency of pain, burning, paresthesia, and numbness. Symptom scores were summed, and the TSSs ranged from 0 to 14.64 (Supplementary Table 3). A monofilament examination, ankle reflex test, and vibration test were performed to evaluate sensory function.
Patients with a TSS of at least 2 and who showed abnormal sensory function tests were defined as having probable peripheral neuropathy. Patients who had symptoms or abnormal tests were defined as having possible peripheral neuropathy.
Statistical methods
Statistical analyses were performed using SPSS version 14.0 (SPSS Inc., Chicago, IL, USA). Data were expressed as mean±standard error. An independent t-test or chi-square test was used to make comparisons between the groups. Continuous variables were tested with an independent t-test, and discrete variables were tested with a chi-square test. A P value less than 0.05 was considered statistically significant.
Patient characteristics
A total of 442 participants were included in this study. The participants were divided into T2DM patients (n=258) and controls (n=184). The characteristics of each group are summarized in Table 2.
The mean age of patients was higher (57.7±0.6 years vs. 52.7±0.6 years, P<0.001), body mass index (BMI) was higher (25.1±0.2 vs. 23.4±0.2, P<0.001), and cigarette use was more frequent (24% vs. 11%, P=0.008) in the patient group. Systolic blood pressure was also higher (132.2±15.3 mm Hg vs. 124.8±14.1 mm Hg, P<0.001) in the patient group. Diastolic pressure was not significantly different between the two groups (78.4±8.9 mm Hg vs. 76.5±9.8 mm Hg, P=0.101). Laboratory tests showed that total cholesterol (160.1±42.1 vs. 196.5±37.5, P<0.001) and high density lipoprotein cholesterol (46.4±11.4 vs. 53.6±15.2, P<0.001) were lower and triglycerides (135.8±83.9 vs. 129.5±72.1, P<0.001) and fasting plasma glucose (126.9±37.2 vs. 100.9±20.4, P<0.001) were higher in the T2DM patient group. No significant differences were noted in gender, weight, height, alcohol consumption, AST, ALT, or γ-GTP.
GERD and GERD symptoms
The prevalence of GERD showed no difference between the T2DM patient group and the control group (32.6% vs. 35.9%, P=0.266). In endoscopic diagnosis, LA grade A or higher indicated no difference between the two groups either (15.5% vs. 15.7%, P=0.453). Because of the significant differences in age, BMI, and cigarette use between the T2DM patient group and the control group, a Cochran-Mantel-Haenzel test was conducted using an age of 60, BMI of 25, and cigarette use. However, the prevalence of GERD still showed no difference after the revision for risk factors such as age, BMI, and cigarette use, as shown in Table 3.
The prevalence of GERD symptoms also showed no significant difference between the two groups (58.8% vs. 59.2%, P= 0.503) (Table 3).
GERD group and non-GERD group
This study evaluated the differences in clinical characteristics between the GERD group (n=150) and the non-GERD group (n=292) (Table 4). No significant differences were noted between the two groups, which had similar rates of T2DM (56.0% vs. 60.0%, P=0.470), waist measurements (or circumferences; 82.2±8.9 cm vs. 84.1±9.2 cm, P=0.064), BMI (23.9±0.3 vs. 24.8±0.2, P=0.026), rates of cigarette use (16.0% vs. 21.0%, P=0.227), and rates of alcohol consumption (35.0% vs. 38.0%, P=0.566). No differences were detected in blood pressure, fasting glucose levels, or lipid levels.
T2DM patients with GERD and T2DM patients without GERD
The study also evaluated the differences between T2DM patients with GERD and T2DM patients without GERD (Table 5).
No significant differences were noted in clinical and laboratory characteristics. The mean age (56.8±1.0 years vs. 58.3±0.7 years, P=0.234), BMI (24.5±0.5 vs. 25.4±0.3, P=0.059), and cigarette use (18% vs. 25%, P=0.185) showed no differences. Systolic blood pressure (132.5±1.7 mm Hg vs. 132.1±1.2 mm Hg, P=0.828) and diastolic pressure (80.0±1.0 mm Hg vs. 77.7±0.7 mm Hg, P=0.053) were similar between the two groups. γ-GTP (38.5±5.6 mm Hg vs. 27.7±1.7 mm Hg, P= 0.021) was higher in the DM with GERD group, but alcohol consumption (38% vs. 38%, P=0.966) showed no difference.
The duration of DM (8.7±0.8 years vs. 8.5±0.5 years, P=0.808), HbA1c levels (7.1%±0.1% vs. 7.6%±0.4%, P=0.358), and fasting C-peptide levels (3.4±1.7 ng/mL vs. 2.8±1.0 ng/mL, P=0.765) showed no differences. Peripheral neuropathy was also not significantly different between the two groups (probable: 4.1% vs. 8.5%, P=0.159; possible: 28.5% vs. 20.8%, P=0.140). No differences were detected in the percentage of individual treatment drugs (insulin, sulfonylurea, metformin, thiazolidinedione, dipeptidyl peptidase-4 inhibitor, angiotensin-converting enzyme inhibitor, angiotensin receptor blocker, calcium channel blocker, β-blocker, statin, aspirin, and cilostazol) between T2DM patients with GERD and T2DM patients without GERD. The percentages of DiCAN scores rated 1.5 or higher, retinopathy, and max-baPWV also did not differ statistically.
The characteristic symptoms of heartburn or acid regurgitation are critical in the diagnosis of GERD. However, no specific word exists in the Korean language that can precisely express the characteristic "heartburn," so the descriptions of symptoms by patients are very diverse. This complicates the diagnosis of GERD based only on symptoms. GERD patients in Korea also frequently report accompanying atypical symptoms, such as lung pain, throat irritation, and cough, and these symptoms sometimes manifest only in an atypical manner [17]. Hence, objective diagnosis of GERD is important, and this is accomplished in Korea by endoscopy, 24-hour esophageal pH monitoring, and the Bernstein test. Of these methods, endoscopy has very high specificity, at 96%, despite its low sensitivity of 62% to 68% [18]. Diagnosis can be accurate when erosion is observed, and the reliability of GERD diagnosis can be high when correlated with the accompaniment of symptoms in cases of minimal change. In the present study, GERD was defined as LA grade A (or higher) or a minimal change with GERD symptoms.
T2DM has often been identified as a risk factor for GERD occurrence. A study conducted in the United States reported GERD symptoms in approximately 41% of patients with T2DM [9]. Research using a Korean population as a sample determined that 23.1% of T2DM patients complained of typical GERD symptoms [1920]. In other research, upper GI endoscopy on DM patients who complained of gut symptoms revealed erosive esophagitis in 18% of the DM patients, which was a higher percentage than that seen in persons without DM [7]. A recent meta-analysis also reported a correlation between DM and GERD [21]; however, in the present study, the occurrence rate of GERD of 32.6% in the T2DM group and 35.9% in the control group indicated no significant correlation between the presence of diabetes and GERD. Typical GERD symptoms showed a prevalence of 58.8% in the T2DM group and 59.2% in the control group, again indicating no correlation.
Symptoms of GERD are also known risk factors for metabolic syndrome [22]. In fact, overweight or obesity is more commonly observed among T2DM patients. Some studies have indicated that overweight and obesity are also risk factors for symptoms of GERD [112324]. Waist measurements were compared in the present study, but no difference was observed between the GERD and non-GERD groups. Several studies have reported hypertension, dyslipidemia [22], and poor glycemic control [1] as significant factors for the presence of GERD symptoms among T2DM patients. However, no significant differences were noted in blood pressure, lipid levels, fasting glucose level, and HbA1c between the GERD and non-GERD groups in the present study.
Patients with DM and neuropathy more frequently show GI symptoms when compared with DM patients without neuropathy [11]. Recent research reported a higher prevalence of GERD symptoms among DM patients with neuropathy [9], whereas other research has argued that the existence of neuropathy is irrelevant to the GERD symptoms among DM patients, as the prevalence of GERD showed no significant difference between DM patients with neuropathy and DM patients without neuropathy [25]. The present study confirmed that the presence of cardiovascular autonomic neuropathy and peripheral neuropathy in T2DM patients with GERD and T2DM patients without GERD did not affect the prevalence of GERD, with the results indicating similar percentages of TSS ≥2 and abnormal signs (8.5% vs. 4.1%, P=0.159), TSS ≥2 or abnormal signs (28.5% vs. 20.8%, P=0.140), and DiCAN scores of 1.5 or higher (56.0% vs. 55.0%, P=0.894).
The relaxation of the lower esophageal sphincter is held as one reason for GERD, and a variety of medicines are reported to influence this [26]. These medicines include beta-agonists, alpha-adrenergic antagonists, nitrates, calcium channel blockers, anticholinergics, theophylline, morphine, meperidine, diazepam, and barbiturates [26]. Many diabetes patients use calcium channel blockers as hypertension medicines. In this study, however, T2DM patients with GERD showed 25% and those without GERD showed 31% (P=0.380) using calcium channel blockers, indicating no significant difference.
This study was performed on patients who visited Busan St. Mary's Hospital for general checkups (including public corporation checkups). In Korea, the National Health Insurance Service mandates that everyone over age 40 undergo upper gastrointestinography or EGD for the purpose of early diagnosis of stomach cancer, regardless of the presence or absence of symptoms. However, the actual inspection rate for the early diagnosis of stomach cancer in 2009 was 41.3% [27], and 46.9% of the patients who received an early diagnosis of stomach cancer in 2005 visited the hospital for checkups because of the presence of physical symptoms [28], implying the possibility that the test was performed on subjects that showed symptoms. That is, the possibility of overestimation of the prevalence and symptoms of GERD cannot be ruled out in the present study. The present study also has a limitation in that it could not check the factors that influence GERD occurrence, including drugs that affect gastric acid secretion (especially nonsteroidal anti-inflammatory drugs), life habits, and Helicobacter pylori infection. However, the present study has the advantage that every patient underwent EGD and the existence of neuropathy was confirmed through objective testing.
On balance, DM is an unlikely risk factor for GERD symptoms and GERD occurrence. No significant correlation was observed between autonomic or peripheral neuropathy and GERD symptoms and occurrence. Further studies that control for the major factors of GERD occurrence, such as diet and lifestyle, as well as H. pylori infection, will be necessary in the future.

CONFLICTS OF INTEREST: No potential conflict of interest relevant to this article was reported.

Supplementary Table 1

The Los Angeles classification of gastroesophageal reflux disease and minimal change

Supplementary Table 2

The FSSG questionnaire

Supplementary Table 3

Scoringa approach for neuropathic symptomsb included in the total symptom score
  • 1. Bytzer P, Talley NJ, Leemon M, Young LJ, Jones MP, Horowitz M. Prevalence of gastrointestinal symptoms associated with diabetes mellitus: a population-based survey of 15,000 adults. Arch Intern Med 2001;161:1989-1996. ArticlePubMed
  • 2. Revicki DA, Wood M, Maton PN, Sorensen S. The impact of gastroesophageal reflux disease on health-related quality of life. Am J Med 1998;104:252-258. PubMed
  • 3. Wahlqvist P. Symptoms of gastroesophageal reflux disease, perceived productivity, and health-related quality of life. Am J Gastroenterol 2001;96(8 Suppl):S57-S61. ArticlePubMed
  • 4. Vakil N, van Zanten SV, Kahrilas P, Dent J, Jones R. Global Consensus Group. The Montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus. Am J Gastroenterol 2006;101:1900-1920. ArticlePubMed
  • 5. Dent J, El-Serag HB, Wallander MA, Johansson S. Epidemiology of gastro-oesophageal reflux disease: a systematic review. Gut 2005;54:710-717. ArticlePubMedPMC
  • 6. Wong BC, Kinoshita Y. Systematic review on epidemiology of gastroesophageal reflux disease in Asia. Clin Gastroenterol Hepatol 2006;4:398-407. ArticlePubMed
  • 7. Park KH, Yoon SB, Jo MH, Hong EK, Lee SJ, Jeong IK, Park CY, Oh KW, Kim HK, Yu JM, Kim DM, Lim SH, Choi MK, Yoo HJ, Park SW, Oh HY, Kim JB, Baek IH, Lee MS. Clinical characteristics and analysis of risk factor for gastroesophageal reflux disease in diabetic patient. J Korean Diabetes Assoc 2005;29:358-366.
  • 8. Bytzer P, Talley NJ, Hammer J, Young LJ, Jones MP, Horowitz M. GI symptoms in diabetes mellitus are associated with both poor glycemic control and diabetic complications. Am J Gastroenterol 2002;97:604-611. ArticlePubMed
  • 9. Wang X, Pitchumoni CS, Chandrarana K, Shah N. Increased prevalence of symptoms of gastroesophageal reflux diseases in type 2 diabetics with neuropathy. World J Gastroenterol 2008;14:709-712. ArticlePubMedPMC
  • 10. Kase H, Hattori Y, Sato N, Banba N, Kasai K. Symptoms of gastroesophageal reflux in diabetes patients. Diabetes Res Clin Pract 2008;79:e6-e7. ArticlePubMed
  • 11. Nishida T, Tsuji S, Tsujii M, Arimitsu S, Sato T, Haruna Y, Miyamoto T, Kanda T, Kawano S, Hori M. Gastroesophageal reflux disease related to diabetes: analysis of 241 cases with type 2 diabetes mellitus. J Gastroenterol Hepatol 2004;19:258-265. ArticlePubMed
  • 12. Lluch I, Ascaso JF, Mora F, Minguez M, Pena A, Hernandez A, Benages A. Gastroesophageal reflux in diabetes mellitus. Am J Gastroenterol 1999;94:919-924. ArticlePubMed
  • 13. Lundell LR, Dent J, Bennett JR, Blum AL, Armstrong D, Galmiche JP, Johnson F, Hongo M, Richter JE, Spechler SJ, Tytgat GN, Wallin L. Endoscopic assessment of oesophagitis: clinical and functional correlates and further validation of the Los Angeles classification. Gut 1999;45:172-180. ArticlePubMedPMC
  • 14. Kusano M, Shimoyama Y, Sugimoto S, Kawamura O, Maeda M, Minashi K, Kuribayashi S, Higuchi T, Zai H, Ino K, Horikoshi T, Sugiyama T, Toki M, Ohwada T, Mori M. Development and evaluation of FSSG: frequency scale for the symptoms of GERD. J Gastroenterol 2004;39:888-891. ArticlePubMedPDF
  • 15. Ha BK, Kim BG, Kim DH, Lee SI, Jung SM, Park JY, Lee CW, Kim SS, Kim BH, Kim IJ. Relationships between brachial-ankle pulse wave velocity and peripheral neuropathy in type 2 diabetes. Diabetes Metab J 2012;36:443-451. ArticlePubMedPMC
  • 16. Bae YP, Yi BD, Kim BG, Park JH, Kwon YS, Park JY, Lee CW, Kim BH, Jang JS. Relationships between cardiac autonomic neuropathy and the brachial-ankle pulse wave velocity in patients with type 2 diabetes. Endocrinol Metab 2011;26:44-52.Article
  • 17. Lee SH, Choi MG, Park SH, Choi H, Moon SB, Choo KY, Wang JH, Kim JK, Choi KY, Chung KW, Sun HS. The clinical spectrum of gastroesophagel reflux disease in Korea. Korean J Gastrointest Motil 2000;6:1-10.
  • 18. Richter JE. Diagnostic tests for gastroesophageal reflux disease. Am J Med Sci 2003;326:300-308. ArticlePubMed
  • 19. Cho YS, Choi MG, Jeong JJ, Chung WC, Lee IS, Kim SW, Han SW, Choi KY, Chung IS. Prevalence and clinical spectrum of gastroesophageal reflux: a population-based study in Asan-si, Korea. Am J Gastroenterol 2005;100:747-753. ArticlePubMed
  • 20. Jeong JJ, Choi MG, Cho YS, Lee SG, Oh JH, Park JM, Cho YK, Lee IS, Kim SW, Han SW, Choi KY, Chung IS. Chronic gastrointestinal symptoms and quality of life in the Korean population. World J Gastroenterol 2008;14:6388-6394. ArticlePubMedPMC
  • 21. Sun XM, Tan JC, Zhu Y, Lin L. Association between diabetes mellitus and gastroesophageal reflux disease: a meta-analysis. World J Gastroenterol 2015;21:3085-3092. ArticlePubMedPMC
  • 22. Hirata A, Kishida K, Nakatsuji H, Inoue K, Hiuge-Shimizu A, Funahashi T, Shimomura I. High prevalence of gastroesophageal reflux symptoms in type 2 diabetics with hypoadiponectinemia and metabolic syndrome. Nutr Metab (Lond) 2012;9:4ArticlePubMedPMCPDF
  • 23. El-Serag HB, Graham DY, Satia JA, Rabeneck L. Obesity is an independent risk factor for GERD symptoms and erosive esophagitis. Am J Gastroenterol 2005;100:1243-1250. ArticlePubMed
  • 24. Nilsson M, Johnsen R, Ye W, Hveem K, Lagergren J. Obesity and estrogen as risk factors for gastroesophageal reflux symptoms. JAMA 2003;290:66-72. ArticlePubMed
  • 25. Lee SD, Keum B, Chun HJ, Bak YT. Gastroesophageal reflux disease in type II diabetes mellitus with or without peripheral neuropathy. J Neurogastroenterol Motil 2011;17:274-278. ArticlePubMedPMC
  • 26. Feldman M, Sleisenger MH, Friedman LS. Chapter 33, Gastroesophageal reflux disease and its complications, including Barrett's metaplasia. Sleisenger & Fordtran's gastrointestinal and liver disease: pathophysiology, diagnosis, management. 7th ed. Philadelphia: W.B. Saunders; 2002. p. 599-622.
  • 27. National Health Insurance Corporation. 2009 National health screening statistical yearbook. Seoul: National Health Insurance Corporation; 2010.
  • 28. Kwak MS, Park EC, Bang JY, Sung NY, Lee JY, Choi KS. Factors associated with cancer screening participation, Korea. J Prev Med Public Health 2005;38:473-481. PubMed
Table 1

Comparison of endoscopic GERD findings between initial decodes and final decodes (κ=0.703, P<0.001)

Initial Final Total
Normal GERD, minimal GERD, LA-A or higher
Normal 143 0 0 143
GERD, minimal 38 192 40 270
GERD, LA-A or higher 0 0 29 29
Total 181 192 69 442

GERD, gastroesophageal reflux disease; LA-A, Los Angeles grade A.

Table 2

Comparison of baseline characteristics between the two groups

Characteristic T2DM patients (n=258) Controls (n=184) P value
 Age, yr 57.7±0.6 52.7±0.6 <0.001
 Male sex, % 50.4 51.1 0.885
 Weight, kg 65.4±0.7 62.2±0.9 0.004
 Height, cm 161.4±0.6 162.34±0.7 0.307
 Body mass index, kg/m2 25.1±0.2 23.4±0.2 <0.001
 Cigarette use, % 24 11 0.008
 Alcohol consumption, % 39 36 0.604
 SBP, mm Hg 132.2±1.0 124.8±1.5 <0.001
 DBP, mm Hg 78.4±0.6 76.5±1.1 0.101
 Total cholesterol, mg/dL 160.1±2.6 196.5±2.8 <0.001
 HDL-C, mg/dL 46.4±0.7 53.6±1.1 <0.001
 Triglycerides, mg/dL 135.8±11.4 129.5±5.4 <0.001
 Fasting plasma glucose, mg/dL 126.9±2.3 100.9±1.7 <0.001
 AST, U/L 28.0±0.6 27.6±0.7 0.661
 ALT, U/L 27.6±10.8 24.1±1.0 0.007
 γ-GTP, U/L 31.3±2.2 31.1±2.2 0.971

Values are presented as mean±standard error.

T2DM, type 2 diabetes mellitus; SBP, systolic blood pressure; DBP, diastolic blood pressure; HDL-C, high density lipoprotein cholesterol; AST, aspartate aminotransferase; ALT, alanine aminotransferase; γ-GTP, gamma-glutamyltranspeptidase.

Table 3

Prevalence of GERD and GERD symptoms in T2DM patients and controls

Variable T2DM patients (n=258) Controls (n=184) P value
GERD, % 32.6 35.9 0.266
 LA-A or higher 15.5 15.7 0.453
 Minimal and symptoms 17.1 20.1 0.477
  Age ≥60 (n=138) 31.4 33.3 0.543
  Age <60 (n=304) 33.4 36.5 0.615
  BMI ≥25 (n=171) 26.8 28.1 0.953
  BMI <25 (n=271) 37.8 36.8 0.955
  Smoking (n=144) 29.9 32.1 0.472
  Nonsmoking (n=298) 34.2 36.4 0.554
GERD symptoms, % 58.8 59.2 0.503

GERD, gastroesophageal reflux disease; T2DM, type 2 diabetes mellitus; LA-A, Los Angeles grade A; BMI, body mass index.

Table 4

Comparison of clinical characteristics between the GERD group and the non-GERD group

Characteristic GERD (n=150) Non-GERD (n=292) P value
 Age, yr 55.0±0.7 56.1±0.5 0.241
 Male sex, % 58.7 51.0 0.639
 Weight, kg 63.2±1.0 64.6±0.6 0.223
 Height, cm 162.0±0.8 161.4±0.5 0.581
 Body mass index, kg/m2 23.9±0.3 24.8±0.2 0.026
 Cigarette use, % 16.0 21.0 0.227
 Alcohol consumption, % 35.0 38.0 0.566
 SBP, mm Hg 129.2±1.4 130.7±1.0 0.390
 DBP, mm Hg 78.4±0.9 77.6±0.6 0.437
 Total cholesterol, mg/dL 182.0±4.1 171.7±2.4 0.681
 HDL-C, mg/dL 50.5±1.3 48.8±0.7 0.219
 Triglycerides, mg/dL 157.8±19.5 120.5±3.9 0.013
 Fasting plasma glucose, mg/dL 115.6±2.8 118.2±2.2 0.483
 AST, U/L 28.5±0.8 27.6±0.5 0.340
 ALT, U/L 26.7±1.3 25.9±0.7 0.565
 γ-GTP, U/L 35.3±3.7 29.2±1.5 0.069

Values are presented as mean±standard error.

GERD, gastroesophageal reflux disease; SBP, systolic blood pressure; DBP, diastolic blood pressure; HDL-C, high density lipoprotein cholesterol; AST, aspartate aminotransferase; ALT, alanine aminotransferase; γ-GTP, gamma-glutamyltranspeptidase.

Table 5

Comparison of clinical characteristics between the GERD group and the non-GERD group in DM patients

Characteristic DM with GERD (n=84) DM without GERD (n=174) P value
 Age, yr 56.8±1.0 58.3±0.7 0.234
 Male sex, % 47.6 51.7 0.837
 Weight, kg 65.0±1.3 65.5±0.8 0.720
 Height, cm 162.5±1.0 160.7±0.7 0.131
 Body mass index, kg/m2 24.5±0.5 25.4±0.3 0.059
 Cigarette use, % 18 25 0.185
 Alcohol consumption, % 38 38 0.966
 SBP, mm Hg 132.5±1.7 132.1±1.2 0.828
 DBP, mm Hg 80.0±1.0 77.7±0.7 0.053
 Total cholesterol, mg/dL 166.9±5.6 157.1±2.8 0.082
 HDL-C, mg/dL 45.8±1.1 46.7±0.9 0.559
 Triglycerides, mg/dL 158.9±23.7 135.4±9.7 0.065
 AST, U/L 28.6±1.1 27.7±0.6 0.471
 ALT, U/L 28.0±1.6 27.4±0.9 0.698
 γ-GTP, U/L 38.5±5.6 27.7±1.7 0.021
 Duration of DM, yr 8.7±0.8 8.5±0.5 0.808
 Glycosylated hemoglobin, % 7.1±0.1 7.6±0.4 0.358
 Fasting plasma glucose, mg/dL 126.7±3.8 126.8±2.9 0.982
 Fasting insulin, µU/mL 10.6±1.2 12.6±1.7 0.442
 Fasting C-peptide, ng/mL 3.4±1.7 2.8±1.0 0.765
 DiCAN score ≥1.5, % 56.0 55.0 0.894
 TSS ≥2 and abnormal sign, % 8.5 4.1 0.159
 TSS ≥2 or abnormal sign, % 28.5 20.8 0.140
 Max-baPWV, m/sec 1,566.8±31.9 1,624.4±27.1 0.203
 Retinopathy, % 27.0 22.0 0.420
 Insulin (basal), % 25 22 0.636
 Insulin (prandial), % 7 5 0.528
 Sulfonylurea, % 30 30 0.552
 Metformin, % 86 81 0.387
 Thiazolidinedione, % 4 5 0.569
 DPP-4 inhibitor, % 27 27 1.000
 ACE inhibitor, % 5 4 0.752
 ARB, % 36 37 0.891
 CCB, % 25 31 0.380
 β-Blocker, % 7 11 0.378
 Statin, % 62 57 0.502
 Aspirin, % 20 17 0.607
 Cilostazol, % 11 11 1.000

Values are presented as mean±standard error.

GERD, gastroesophageal reflux disease; DM, diabetes mellitus; SBP, systolic blood pressure; DBP, diastolic blood pressure; HDL-C, high density lipoprotein cholesterol; AST, aspartate aminotransferase; ALT, alanine aminotransferase; γ-GTP, gamma-glutamyltranspeptidase; TSS, total symptom score; baPWV, brachial-ankle pulse wave velocity; DPP-4, dipeptidyl peptidase-4; ACE, angiotensin-converting enzyme; ARB, angiotensin receptor blocker; CCB, calcium channel blocker.

Figure & Data



    Citations to this article as recorded by  
    • Ураження органів травлення при цукровому діабеті
      M.O. Borovets , О.М. Radchenko , Kh.A. Moskva , O.Yo. Komarytsya , A.M. Urbanovych
      Endokrynologia.2023; 28(3): 270.     CrossRef
    • Metabolic effects of bariatric surgery on patients with type 2 diabetes: a population-based study
      Erman O. Akpinar, Ronald S.L. Liem, Simon W. Nienhuijs, Jan Willem M. Greve, Perla J. Marang-van de Mheen, L.M. de Brauw, S.M.M. de Castro, S.L. Damen, A. Demirkiran, M. Dunkelgrun, I.F. Faneyte, G. van ‘t Hof, I.M.C. Janssen, R.A. Klaassen, E.A.G.L. Laga
      Surgery for Obesity and Related Diseases.2021; 17(7): 1349.     CrossRef
    • The effect of proton pump inhibitors on glycaemic control in diabetic patients
      Muhammad Ali Rajput, Fizzah Ali, Tabassum Zehra, Shahid Zafar, Gunesh Kumar
      Journal of Taibah University Medical Sciences.2020; 15(3): 218.     CrossRef
    • Prediabetes and gastrointestinal (GI) symptoms; a cross-sectional study
      Akram Ghadiri-Anari, Somaye Gholami, Fariba Zolfaghari, Nasim Namiranian
      Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2019; 13(1): 844.     CrossRef
    • Gastrointestinal Symptoms in Diabetes: Prevalence, Assessment, Pathogenesis, and Management
      Yang T. Du, Christopher K. Rayner, Karen L. Jones, Nicholas J. Talley, Michael Horowitz
      Diabetes Care.2018; 41(3): 627.     CrossRef
    • Features of Endoscopic Changes in Gastroesophageal Reflux Disease in Patients with Type II Diabetes Mellitus
      Ye. S. Sirchak, M. P. Stan, Yo. I. Pichkar, V. V. Vajs
      Ukraïnsʹkij žurnal medicini, bìologìï ta sportu.2018; 3(5): 166.     CrossRef
    • Prevalence and Correlates of Gastroesophageal Reflux Disease in Southern Iran: Pars Cohort Study
      Zohre Khodamoradi, Abdullah Gandomkar, Hossein Poustchi, Alireza Salehi, Mohammad Hadi Imanieh, Arash Etemadi, Reza Malekzadeh
      Middle East Journal of Digestive Diseases.2017; 9(3): 129.     CrossRef
    • Letter: Prevalence and Risk Factors of Gastroesophageal Reflux Disease in Patients with Type 2 Diabetes Mellitus (Diabetes Metab J2016;40:297-307)
      Dongwon Yi
      Diabetes & Metabolism Journal.2016; 40(5): 418.     CrossRef
    • Response: Prevalence and Risk Factors of Gastroesophageal Reflux Disease in Patients with Type 2 Diabetes Mellitus (Diabetes Metab J2016;40:297-307)
      Jun Ouk Ha, Tae Hee Lee, Chang Won Lee
      Diabetes & Metabolism Journal.2016; 40(5): 420.     CrossRef

    • PubReader PubReader
    • Cite this Article
      Cite this Article
      export Copy Download
      Download Citation
      Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.

      • RIS — For EndNote, ProCite, RefWorks, and most other reference management software
      • BibTeX — For JabRef, BibDesk, and other BibTeX-specific software
      • Citation for the content below
      Prevalence and Risk Factors of Gastroesophageal Reflux Disease in Patients with Type 2 Diabetes Mellitus
      Diabetes Metab J. 2016;40(4):297-307.   Published online June 8, 2016
    • XML DownloadXML Download
    Related articles
    Ha JO, Lee TH, Lee CW, Park JY, Choi SH, Park HS, Lee JS, Lee SH, Seo EH, Kim YH, Kang YW. Prevalence and Risk Factors of Gastroesophageal Reflux Disease in Patients with Type 2 Diabetes Mellitus. Diabetes Metab J. 2016;40(4):297-307.
    Received: Jul 31, 2015; Accepted: Oct 19, 2015

    Diabetes Metab J : Diabetes & Metabolism Journal