Diabetes Metab J > Volume 45(6); 2021 > Article
Metabolic risk/Epidemiology
Diabetes & Metabolism Journal 2021;45(6):799-812.
DOI: https://doi.org/10.4093/dmj.2021.0077    Published online November 22, 2021.
Obesity, Diabetes, and Increased Cancer Progression
Dae-Seok Kim1  , Philipp E. Scherer1,2 
1Touchstone Diabetes Center, Department of Internal Medicine, Dallas, TX, USA
2Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA
Correspondence:  Philipp E. Scherer,
Email: philipp.scherer@utsouthwestern.edu
Received: 26 April 2021   • Accepted: 27 July 2021
Abstract
Rates of obesity and diabetes have increased significantly over the past decades and the prevalence is expected to continue to rise further in the coming years. Many observations suggest that obesity and diabetes are associated with an increased risk of developing several types of cancers, including liver, pancreatic, endometrial, colorectal, and post-menopausal breast cancer. The path towards developing obesity and diabetes is affected by multiple factors, including adipokines, inflammatory cytokines, growth hormones, insulin resistance, and hyperlipidemia. The metabolic abnormalities associated with changes in the levels of these factors in obesity and diabetes have the potential to significantly contribute to the development and progression of cancer through the regulation of distinct signaling pathways. Here, we highlight the cellular and molecular pathways that constitute the links between obesity, diabetes, cancer risk and mortality. This includes a description of the existing evidence supporting the obesity-driven morphological and functional alternations of cancer cells and adipocytes through complex interactions within the tumor microenvironment.
Key Words: Adipokines, Adipose tissue, Neoplasms, Diabetes mellitus, type 2, Hyperlipidemia, Insulin resistance, Obesity


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