1. Sears B, Perry M. The role of fatty acids in insulin resistance. Lipids Health Dis 2015;14:121.
Article PubMed PMC
2. Sanyal AJ, Campbell-Sargent C, Mirshahi F, Rizzo WB, Contos MJ, Sterling RK, et al. Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities. Gastroenterology 2001;120:1183-92.
Article PubMed
3. Fillmore N, Mori J, Lopaschuk GD. Mitochondrial fatty acid oxidation alterations in heart failure, ischaemic heart disease and diabetic cardiomyopathy. Br J Pharmacol 2014;171:2080-90.
Article PubMed PMC
4. Guo W, Li D, You Y, Li W, Hu B, Zhang S, et al. Cystathionine γ-lyase deficiency aggravates obesity-related insulin resistance-via FoxO1-dependent hepatic gluconeogenesis. FASEB J 2019;33:4212-24.
PubMed
5. Park MS, Kang JS, Chon CY, Paik SW, Rim KS, Kwak MJ, et al. Oral Godex capsule for chronic liver disease: a double-blind, randomized, multicenter controlled trial. J Korean Soc Clin Pharmacol Ther 2001;9:151-62.
Article
6. Jun DW, Kim BI, Cho YK, Kim HJ, Kwon YO, Park SY, et al. Efficacy and safety of entecavir plus carnitine complex (GODEX(R)) compared to entecavir monotherapy in patient with ALT elevated chronic hepatitis B: randomized, multicenter open-label trials: the GOAL study. Clin Mol Hepatol 2013;19:165-72.
Article PubMed PMC
7. Sin JS, Jung EY, Lee MH, Kang JK. Therapeutic effect of the Godex on the liver cirrhosis induced by CCl4 and ethanol in the rat. J Appl Pharmacol 2002;10:200-7.
8. Hong ES, Kim EK, Kang SM, Khang AR, Choi SH, Park KS, et al. Effect of carnitine-orotate complex on glucose metabolism and fatty liver: a double-blind, placebo-controlled study. J Gastroenterol Hepatol 2014;29:1449-57.
Article PubMed
9. Bae JC, Lee WY, Yoon KH, Park JY, Son HS, Han KA, et al. Improvement of nonalcoholic fatty liver disease with carnitine-orotate complex in type 2 diabetes (CORONA): a randomized controlled trial. Diabetes Care 2015;38:1245-52.
Article PubMed
10. Muoio DM, Noland RC, Kovalik JP, Seiler SE, Davies MN, DeBalsi KL, et al. Muscle-specific deletion of carnitine acetyltransferase compromises glucose tolerance and metabolic flexibility. Cell Metab 2012;15:764-77.
Article PubMed PMC
11. Seiler SE, Martin OJ, Noland RC, Slentz DH, DeBalsi KL, Ilkayeva OR, et al. Obesity and lipid stress inhibit carnitine acetyltransferase activity. J Lipid Res 2014;55:635-44.
Article PubMed PMC
12. Ringseis R, Keller J, Eder K. Role of carnitine in the regulation of glucose homeostasis and insulin sensitivity: evidence from in vivo and in vitro studies with carnitine supplementation and carnitine deficiency. Eur J Nutr 2012;51:1-18.
Article PubMed PMC
13. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972;18:499-502.
Article PubMed
14. Attane C, Foussal C, Le Gonidec S, Benani A, Daviaud D, Wanecq E, et al. Apelin treatment increases complete fatty acid oxidation, mitochondrial oxidative capacity, and biogenesis in muscle of insulin-resistant mice. Diabetes 2012;61:310-20.
Article PubMed PMC
15. Kleiner DE, Brunt EM, Van Natta M, Behling C, Contos MJ, Cummings OW, et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 2005;41:1313-21.
Article PubMed
16. Folch J, Lees M, Sloane Stanley GH. A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 1957;226:497-509.
Article PubMed
17. Kim HS, Noh JH, Hong SH, Hwang YC, Yang TY, Lee MS, et al. Rosiglitazone stimulates the release and synthesis of insulin by enhancing GLUT-2, glucokinase and BETA2/NeuroD expression. Biochem Biophys Res Commun 2008;367:623-9.
Article PubMed
18. Stojkovic M, Machado SA, Stojkovic P, Zakhartchenko V, Hutzler P, Goncalves PB, et al. Mitochondrial distribution and adenosine triphosphate content of bovine oocytes before and after in vitro maturation: correlation with morphological criteria and developmental capacity after in vitro fertilization and culture. Biol Reprod 2001;64:904-9.
PubMed
19. Kahn BB, Flier JS. Obesity and insulin resistance. J Clin Invest 2000;106:473-81.
Article PubMed PMC
20. Parra M, Stahl S, Hellmann H. Vitamin B6 and its role in cell metabolism and physiology. Cells 2018;7:84.
Article PMC
21. Liu Z, Li P, Zhao ZH, Zhang Y, Ma ZM, Wang SX. Vitamin B6 prevents endothelial dysfunction, insulin resistance, and hepatic lipid accumulation in Apoe (-/-) mice fed with high-fat diet. J Diabetes Res 2016;2016:1748065.
PubMed
22. Tsuchida A, Yamauchi T, Takekawa S, Hada Y, Ito Y, Maki T, et al. Peroxisome proliferator-activated receptor (PPAR) alpha activation increases adiponectin receptors and reduces obesity-related inflammation in adipose tissue: comparison of activation of PPARalpha, PPARgamma, and their combination. Diabetes 2005;54:3358-70.
Article PubMed
23. Kim SS, Oh HY, Kim HR, Yang JS, Kim DS, Sheen YY, et al. Effect of biphenyl dimethyl dicarboxylate on cytochrome P450 1A1 and 2B1 and CCl4-induced hepatotoxicity in rat liver. Yakhak Hoeji 1999;43:827-33.
24. Renjith RS, Rajamohan T. Protective and curative effects of Cocos nucifera inflorescence on alloxan-induced pancreatic cytotoxicity in rats. Indian J Pharmacol 2012;44:555-9.
Article PubMed PMC
25. Jocken JW, Langin D, Smit E, Saris WH, Valle C, Hul GB, et al. Adipose triglyceride lipase and hormone-sensitive lipase protein expression is decreased in the obese insulin-resistant state. J Clin Endocrinol Metab 2007;92:2292-9.
Article PubMed
26. Couturier A, Ringseis R, Mooren FC, Kruger K, Most E, Eder K. Carnitine supplementation to obese Zucker rats prevents obesity-induced type II to type I muscle fiber transition and favors an oxidative phenotype of skeletal muscle. Nutr Metab (Lond) 2013;10:48.
Article PubMed PMC
27. Bruls YM, de Ligt M, Lindeboom L, Phielix E, Havekes B, Schaart G, et al. Carnitine supplementation improves metabolic flexibility and skeletal muscle acetylcarnitine formation in volunteers with impaired glucose tolerance: a randomised controlled trial. EBio Medicine 2019;49:318-30.
Article
28. De Gaetano A, Mingrone G, Castagneto M, Calvani M. Carnitine increases glucose disposal in humans. J Am Coll Nutr 1999;18:289-95.
Article PubMed
29. Mingrone G, Greco AV, Capristo E, Benedetti G, Giancaterini A, De Gaetano A, et al. L-carnitine improves glucose disposal in type 2 diabetic patients. J Am Coll Nutr 1999;18:77-82.
Article PubMed
30. Lopaschuk GD. Fatty acid oxidation and its relation with insulin resistance and associated disorders. Ann Nutr Metab 2016;68 Suppl 3:15-20.
Article PubMed
31. Montgomery MK, Brown SH, Mitchell TW, Coster AC, Cooney GJ, Turner N. Association of muscle lipidomic profile with high-fat diet-induced insulin resistance across five mouse strains. Sci Rep 2017;7:13914.
Article PubMed PMC
32. Li Y, Xu S, Mihaylova MM, Zheng B, Hou X, Jiang B, et al. AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice. Cell Metab 2011;13:376-88.
Article PubMed PMC
33. Horton JD, Goldstein JL, Brown MS. SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest 2002;109:1125-31.
Article PubMed PMC
34. Lagace TA, Curtis DE, Garuti R, McNutt MC, Park SW, Prather HB, et al. Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice. J Clin Invest 2006;116:2995-3005.
Article PubMed PMC
35. Zhang DW, Lagace TA, Garuti R, Zhao Z, McDonald M, Horton JD, et al. Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat A of low density lipoprotein receptor decreases receptor recycling and increases degradation. J Biol Chem 2007;282:18602-12.
Article PubMed
36. Rong S, Cortes VA, Rashid S, Anderson NN, McDonald JG, Liang G, et al. Expression of SREBP-1c requires SREBP-2-mediated generation of a sterol ligand for LXR in livers of mice. Elife 2017;6:e25015.
Article PubMed PMC
37. Altamimi TR, Thomas PD, Darwesh AM, Fillmore N, Mahmoud MU, Zhang L, et al. Cytosolic carnitine acetyltransferaseas a source of cytosolic acetyl-CoA: a possible mechanism for regulation of cardiac energy metabolism. Biochem J 2018;475:959-76.
PubMed
38. Sunny NE, Satapati S, Fu X, He T, Mehdibeigi R, Spring-Robinson C, et al. Progressive adaptation of hepatic ketogenesis in mice fed a high-fat diet. Am J Physiol Endocrinol Metab 2010;298:E1226-35.
Article PubMed PMC
39. Koves TR, Ussher JR, Noland RC, Slentz D, Mosedale M, Ilkayeva O, et al. Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance. Cell Metab 2008;7:45-56.
Article PubMed
40. Garcia-Ruiz I, Solis-Munoz P, Fernandez-Moreira D, Grau M, Colina F, Munoz-Yague T, et al. High-fat diet decreases activity of the oxidative phosphorylation complexes and causes nonalcoholic steato hepatitis in mice. Dis Model Mech 2014;7:1287-96.
PubMed PMC
41. McCarty M, DiNicolantonio JJ, O’Keefe JH. The ability of carnitine to act as a type 1 histone deacetylase inhibitor may explain the favorable impact of carnitine supplementation on mitochondrial biogenesis in the elderly. Med Res Arch 2020;8:1-22.
42. Fernandez-Marcos PJ, Auwerx J. Regulation of PGC-1α, a nodal regulator of mitochondrial biogenesis. Am J Clin Nutr 2011;93:884S-90S.
Article PubMed PMC
43. Fulco M, Cen Y, Zhao P, Hoffman EP, McBurney MW, Sauve AA, et al. Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt. Dev Cell 2008;14:661-73.
Article PubMed PMC
44. Canto C, Gerhart-Hines Z, Feige JN, Lagouge M, Noriega L, Milne JC, et al. AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity. Nature 2009;458:1056-60.
Article PubMed PMC
45. Vega RB, Huss JM, Kelly DP. The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor alpha in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes. Mol Cell Biol 2000;20:1868-76.
Article PubMed PMC
46. Rodgers JT, Lerin C, Haas W, Gygi SP, Spiegelman BM, Puigserver P. Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature 2005;434:113-8.
Article PubMed
47. Purushotham A, Schug TT, Xu Q, Surapureddi S, Guo X, Li X. Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation. Cell Metab 2009;9:327-38.
Article PubMed PMC
48. Fuller SJ, Randle PJ. Reversible phosphorylation of pyruvate dehydrogenasein rat skeletal-muscle mitochondria: effects of starvation and diabetes. Biochem J 1984;219:635-46.
PubMed PMC
49. Uziel G, Garavaglia B, Di Donato S. Carnitine stimulation of pyruvate dehydrogenase complex (PDHC) in isolated human skeletal muscle mitochondria. Muscle Nerve 1988;11:720-4.
Article PubMed
50. Goldberg EL, Dixit VD. Carnitine acetyltransferase (CRAT) expression in macrophages is dispensable for nutrient stress sensing and inflammation. Mol Metab 2017;6:219-25.
Article PubMed PMC