We have not yet any dats on the patterns of dibetes reponses to administered insuIin in Korea diabetics. The authors had an opportunity to study on the blood glucose response to singIe injection of intermediate-acting insulin in Korean insulin- requiring diabetice. The results obtained were as followings: 1) WhiIe the majority of patients(74.6% of 123 cases) obtain a satisfactory 24-hour clinical response to a single dose of NPH insnlin(normal pattern), transient pattern was presented in 11.4%, delayed pattern in 10.6%, and brittle pattern in 10.6%. 2. Normal response pattern was more common in female than male and deIayed response pattern was more common over 60 years old. 3)Among the cases with diabetes over 10 years, delayed response pattern was the highest incidenee with 76. 9%.