Dynamic Modulation of Human Erythrocyte Insulin Receptor by Insulin in Vitro

Korean Diabetes Journal 1985;9(1):33-40.

Byung Ho Kim , Jeong Taek Woo , In Myung Yang , Jin Woo Kim , Young Seol Kim , Kwang Won Kim , Sun Woo Kim , Young Kil Choi

원저 : 사람 적혈구 인슐린 수용체의 인슐린에 의한 역동조절

김병호 , 우정택 , 양인명 , 김진우 , 김영설 , 김광원 , 김선우 , 최영길

Abstract

In order to evalate the clinical usefulness of glycosylated hemoglobin and blood sugar level in 25 normal persons and 25 diabetic patienrs before and after diabetic treatment. The glycosylated henoglobin level in diabetics was significantly higher than that of normal control (9.4~1.6% vs 4.5~0.63%). After control of blood sugar in diabetics, the glycosylated hemoglobin level was significantly decreased compared with that of untreated diabetics, (from 9.4 +- 1.69% to7.7+-1.10%, p<0.005) but in 16% of cases, the glycosylated hemoglobin level was increased after treatment. Correlation between glycosylated hemoglobin and blood sugar level was significant as a whole(r= 0. 606, p<0. 001), but not significant in before or after diabetic control separately. The gIycosylated hemoglobin level of diahetic whose duratinn of illness was longer than 5 years was slightly higher than that of diabetics whose duration of illness was shorter than 5 years. The glycosylated hemoglobin level in diabetics with retinopathy was lower than that. Of diabetics without retinopathy. These resuIts suggest that, HbA,, measured by ordinary chroinatographic or electrophoretic method does not seems to be an accurate .indicator of long-term blood sugar control.