As the abnormalities of glucose metabolism are among the commonest problem in cliniccal practice, it is required to measure the blood sugar levels accuratly and rapidly without resort to laboratory assistance. Following the introductlon of Dextrostix Reflectance Melter, many reports demonstrated that Dextrostix Reflectance Melter was shown to have excellent result as were conventional laborator techniques. Recently, attempts to atililze this techniques with cerebrospinal fluid have been designed we studied the correlation between the Dextrostix Reflectance Melter method and O.T.B.(O.Tolaizine Bolate) technique based on glucosue oxidase method in the measurement of cerebrospinal fluid glucose. The result were as follows: 1. The range for cerebrospinal fluid glucose by Dextrostix Reflectometer method was 20 ~ 170 mg/dl (mean; 63.93mg/dl). 2. Dextrosticx reagent strin determinations of cerebrospinal fluid glucose by reflectometer was showen to have significant correlation with O.T.B. technique based on glucose oxidase method (r=0.9333. Y=1.05X-10.36). Therefore, it is suggested that the use of Dextrostlx Reflectance Melter may provlde a rapid and accurate estimation of cerberospinal fluid glucose.