Side Reaction and its Management of the Oral Hypoglycemic Agents

Korean Diabetes Journal 1984;8(1):1-3.

B . S . Min , S . K . Kang

원저 : 당뇨병 (糖尿病) 내복약의 부작용 및 대책

민병석 , 강성구

Abstract

We studied on 53 RH-787 inoxicated patients prospectively and analyzed 198 reported cases. The results were as follows. 1)The proporf-ian of male to female was 1 to 2.3 ranging from 1 year and 8 months to 67 years of age, and they ingested 5 to 62,5 gm of RH-787 for the suicidal purpose in the majority of patient(66.9%) 2)Clinical symptoms were nausea(36.8%), distuibance of consciousness(36,8%), abdominal pain, urinary disturbance, sensory disturbance, general weakness,and anorexia. 3) About 80% of patient showed fasting hyperglycemia or abnormal glucoae tolerence curve, and ketois were in 50% of patients. 4) Such cases as gastric lavages were performed within 15 miniutes after ingestion of RH-787 showed no hyperglycemia or abnormal gucose tolernece curve. 5)Abnormal laboratory findings such as Ieukocytosis(62.5%), elevated BUN and creatinine and proteinuria, elevated SGOT and alkaline phosphatase levels were noted, they were normalized however,following by control of glucose. 6) Cerebrospinal fluid examination showed normal ranges of pressure, color and cell counts increasd glucose (58.0%) and protein (47.7%) 7)Pathologic findings reported massive necrosis of Langerhann's island of pancreas, fatty change of river, vacuoIes and.acute necrosis in tubular epithelium in kiddney.