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Epidemiological Studies on Diabetes Mellitus in Korea
Diabetes & Metabolism Journal 1979;5(1):1-7
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Nineteen cases of intixication of RH-787 (N-3-pyridylmethyl-N-p-nitrophenylirea), a new class of rodenticide, were analyzed cIinicalIy and the result.; were as follows. 1. Clinical symptoms, physicaI findings, laboratory findings of 19 case and autopsy findings of one case of RH-787 intoxication showd similar findings of streptozotocin induced diabetes mellitus. 2. Clinical symptoms and physical finding could be summarized as nausea, vomiting, epigastric tenderness, drowsy mental state, mydriasis, and urinary retention. 3.All cases examined showed abnormal findings such as glycosuria, ketanuria, hyperglycemia, increased BUN and creatinine level increaeed amylase level and leucocytosis. 4. Plasrnna insulin levels were decreased in aIl cases of 6 patients. An autopsy was done in one case, which revealed fatty change of liver, destructive changes of Langerhsan's island of panereas and acute tubular necrosis of kidney. 6.Overall mortality including two cases of moribund disharge was 75%.

Diabetes Metab J : Diabetes & Metabolism Journal