Skip Navigation
Skip to contents

Diabetes Metab J : Diabetes & Metabolism Journal

Search
OPEN ACCESS

Articles

Page Path
HOME > Diabetes Metab J > Volume 45(4); 2021 > Article
Brief Report
Drug/Regimen A Multicentre, Multinational, Open-Label, 52-Week Extension Study of Gemigliptin (LC15-0444) Monotherapy in Patients with Type 2 Diabetes Mellitus
Sae Jeong Yang1orcid, Kyung Wan Min2, Sandeep Kumar Gupta3, Joong Yeol Park4, Vyankatesh K. Shivane5, Pankaj Kumar Agarwal6, Doo Man Kim7, Yong Seung Kim8, Sei Hyun Baik9orcid
Diabetes & Metabolism Journal 2020;45(4):606-612.
DOI: https://doi.org/10.4093/dmj.2020.0047
Published online: September 9, 2020
  • 4,895 Views
  • 139 Download
  • 1 Crossref
  • 1 Scopus

1Department of Endocrinology, Daerim St. Mary’s Hospital, Seoul, Korea

2Department of Internal Medicine, Nowon Eulji Medical Center, Eulji University School of Medicine, Seoul, Korea

3M.V. Hospital and Research Centre, Lucknow, India

4Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea

5Research Health Institute in Diabetes, Endocrinology and Metabolism (RHIDEM), Mumbai, India

6Hormone Care and Research Center, Ghaziabad, India

7Department of Internal Medicine, Hallym University Kangdong Sacred Heart Hospital, Seoul, Korea

8Department of Internal Medicine, Inha University Hospital, Inha University College of Medicine, Incheon, Korea

9Department of Endocrinology, Korea University Guro Hospital, Seoul, Korea

Corresponding author: Sei Hyun Baik orcid Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University Guro Hospital, 148 Gurodong-ro, Guro-gu, Seoul 08308, Korea E-mail: 103hyun@gmail.com
• Received: February 27, 2020   • Accepted: April 30, 2020

Copyright © 2021 Korean Diabetes Association

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

  • The purpose of this extension study was to assess the long-term efficacy and safety of gemigliptin 50 mg in patients with type 2 diabetes mellitus (T2DM). Patients with T2DM who had completed the initial 24-week study comparing gemigliptin monotherapy with placebo were eligible to enrol. In the open-label, 28-week extension study, all enrolled patients received gemigliptin, regardless of the treatment received during the initial 24-week study period. The mean reduction±standard deviation (SD) in glycosylated hemoglobin (HbA1c) observed after 24 weeks of treatment (–0.6%±1.1%) was further decreased for the gemi-gemi group and the mean change in HbA1c at week 52 from baseline was –0.9%±1.2% (P<0.0001). For the pbo-gemi group, HbA1c decreased after they were switched to gemigliptin, and the mean change in HbA1c at week 52 from baseline was –0.7%±1.2% (P<0.0001). Furthermore, the overall incidence of adverse events demonstrated that gemigliptin was safe and well tolerated up to 52 weeks.
Dipeptidyl peptidase-4 (DPP-4) inhibitors are a class of oral anti-diabetic agents that selectively inhibit the DPP-4 enzyme that degrades the incretin hormones glucagon-like peptide-1 and glucose-dependent insulinotropic peptide [1]. In the general recommendations outlined by American Diabetes Association and European Association for the Study of Diabetes, DPP-4 inhibitors are positioned as a second-line add-on to metformin or as an alternative anti-hyperglycaemic therapy in patients for whom the use of metformin is contraindicated [2]. DPP-4 inhibitors, when administered as monotherapy, were significantly more efficacious in reducing mean glycosylated hemoglobin (HbA1c) from baseline compared to placebo [3]. Furthermore, DPP-4 inhibitors have additive glucose-lowering effects when combined with other oral agents used to treat diabetes [3]. The major benefit of using DPP-4 inhibitors is their low risk of hypoglycaemia, which is expected from their glucose-dependent mechanism of action [4,5].
Gemigliptin is a potent, selective DPP-4 inhibitor, which is indicated as an adjunct to diet and exercise to improve glycaemic control in adults with type 2 diabetes mellitus (T2DM). The present 52-week study was conducted to evaluate the longterm efficacy and safety of gemigliptin when given as monotherapy in patients with T2DM. Results of the initial 24-week, randomized, double-blind, placebo-controlled phase of this study, in which patients with T2DM were given either gemigliptin 50 mg or placebo, have been previously reported [6]. The placebo-subtracted change from baseline in HbA1c was –0.7% (95% confidence interval, –1.04 to –0.37), indicating superior glycaemic control of gemigliptin over placebo [6]. Furthermore, the proportion of patients achieving HbA1c <7% at week 24 was greater in the gemigliptin group (43.0%) when compared with the placebo group (16.0%), with an adverse events (AEs) profile similar to that of the placebo group [6]. In this paper, we report the results of the 28-week, open-label, exploratory investigation, which was conducted subsequently after the completion of the initial 24-week, to assess the longterm safety and efficacy of gemigliptin monotherapy.
Patients with T2DM who completed the initial 24-week phase of the 52-week study, and who had consented to receive further treatment with gemigliptin, could enrol in the 28-week extension study. Methodologies for the randomized treatment phase of the study and inclusion and exclusion criteria have been previously reported [6]. In brief, patients between the ages of 18 and 75 years, with a history of T2DM and HbA1c between 7% and 11%, were enrolled. After the initial 24-week, placebo-treated patients were switched to receive gemigliptin for another 28 weeks, while the patients who were randomly allocated to receive gemigliptin at baseline continued with the same treatment for the entire 52 weeks. Patients who received gemigliptin during both the initial and extension phases were referred to as the ‘gemi-gemi group,’ and patients who received placebo during the initial phase and gemigliptin during the extension phase were referred to as the ‘pbo-gemi group’ (ClinicalTrials.gov Identifier: NCT01601990).
This study was carried out in accordance with the ethical principles laid down in the Declaration of Helsinki and Good Clinical Principles issued by Internal Conference on Harmonization. This study was approved by the Institutional Review Boards of Asan Medical Center (IRB No. 2009-0571), Nowon Eulji Medical Center (IRB No. 09-69), Inha University Hospital (IRB No. 10-06), Hallym University Kangdong Sacred Heart Hospital (IRB No. 09-99). Written informed consent was obtained from all patients.
The primary efficacy endpoint of the extension study was change in HbA1c from baseline at week 52. Key secondary endpoints included the proportion of patients achieving HbA1c <7% and <6.5% at week 52 and changes in fasting plasma glucose (FPG) at week 52 relative to baseline. Please see Table 1 for a complete list of efficacy endpoints measured.
Efficacy was analysed with the full analysis set and safety analyses were based on a safety set. All continuous and categorical efficacy variables were summarized using descriptive statistics. Continuous variables were described by the mean±standard deviation (SD), and assessed by a paired t-test (or Wilcoxon signed rank test), whereas categorical variables were presented as numbers of patients expressed as percentages. All statistical analyses were performed using SAS version 9.1 (SAS Institute, Cary, NC, USA). With the exception of oral glucose tolerance test (OGTT) parameters, missing efficacy variables were imputed using the last observation carried forward method.
In the initial randomized, placebo-controlled study, a total of 182 patients (90 and 92 patients in the gemigliptin and placebo groups, respectively) were enrolled, and 167 patients completed the 24-week of treatment. Of the original population, 165 patients consented to continue the study and receive further treatment of gemigliptin 50 mg for 28 weeks: 158 of these patients completed the entire study. Baseline characteristics and demographics were generally similar for both study groups.
Efficacy results
At week 24, a clinically and statistically significant decrease in HbA1c was observed when treated with gemigliptin 50 mg [6]. No notable change in HbA1c from baseline was observed in the placebo group during the initial 24-week period [6]. During the extension period, a further decrease in HbA1c was observed for the gemi-gemi group, and the mean change±SD in HbA1c at week 52 from baseline was statistically significant (–0.9%± 1.2%, P<0.0001) (Fig. 1A). For the pbo-gemi group, HbA1c decreased after the placebo-treated patients were switched to gemigliptin. The mean change in HbA1c at week 52 from baseline was –0.7%±1.2%, which is similar to the level attained (–0.6%±1.1%) in patients who had received gemigliptin during the initial 24-week double-blind phase of the trial. Furthermore, the proportion of patients achieving HbA1c level of <7% and <6.5% increased with the gemi-gemi group at 52 weeks (HbA1c <7%, 41.3% at week 24 vs. 52.5% at week 52; HbA1c <6.5%, 16.3% at week 24 vs. 26.3% at week 52). In the pbo-gemi group, the proportion of patients reaching HbA1c level of <7% almost doubled (21.1% at week 24 vs. 46.5% at week 52), and those reaching <6.5% increased 6-fold (4.2% at week 24 vs. 23.9% at week 52) after 52 weeks (Fig. 1B). Continued treatment with gemigliptin for 52 weeks also resulted in a significant reduction in FPG. Furthermore, a significant decrease in homeostasis model assessment of insulin resistance from baseline at week 52 was observed in the gemi-gemi group (P=0.0065), suggestive of increased insulin sensitivity. Gemigliptin also reduced postprandial glucose and fasting triglyceride, while significantly increasing high-density lipoprotein in both study groups from baseline at week 52.
At week 52, data from 27 patients were available for analysis of OGTT; however, the number of patients was too small, and the findings from these data were insufficient to draw any conclusive interpretation. Detailed results of the efficacy endpoints are demonstrated in Table 1.
Safety results
Overall, the incidence of AEs was similar between the study groups (58.0% and 60.9% in the pbo-gemi and gemi-gemi groups, respectively), with adverse drug reactions occurring in small percentages of patients. Most of the AEs were mild in severity and resolved without sequelae. No patient was withdrawn because of AEs or serious AEs, and no deaths occurred during this study. Clinically meaningful abnormalities in electrocardiograms or vital signs were not found.
In this 28-week extension study, the gemigliptin-mediated glycaemic control observed during the initial phase was well maintained, and gemigliptin was well tolerated for up to 52 weeks in patients with T2DM. In general, the HbA1c reduction associated with this class of therapies demonstrates a reduction of approximately 0.5% to 1% when used as monotherapy [3]. The glycaemic durability mediated by gemigliptin was also evident in the level of FPG at week 52, which was reduced by twice as much when compared to the result obtained at week 24.
Overall, long-term treatment with gemigliptin was well tolerated. The benign safety profile of DPP-4 inhibitors has been documented in several meta-analyses, and the safety results obtained in this study further contribute to the available evidence [7-9]. One of the clinical advantages of DPP-4 inhibitors includes a low risk of hypoglycaemia [3]. In agreement with the published findings to date, the incidence of hypoglycaemia was relatively low with gemigliptin, occurring only in two patients in the gemi-gemi group.
The limitations of our study include the absence of a control group in the extension period, as the long-term efficacy and safety were assessed in two study groups, both of which received gemigliptin. Nonetheless, placebo-controlled efficacy and safety data up to 24 weeks are available in the prior publication of this study. Moreover, the ability to draw a firm conclusion from the OGTT was diminished because of the limited number of patients who consented to undergo and completed the OGTT. Nevertheless, the findings of this study provide strong evidence for the long-term efficacy and safety of gemigliptin 50 mg monotherapy up to 52 weeks in patients with T2DM.

CONFLICT OF INTEREST

No potential conflict of interest relevant to this article was reported.

AUTHOR CONTRIBUTIONS

Conception or design: S.H.B.

Acquisition, analysis, or interpretation of data: K.W.M., S.K.G., J.Y.P., V.K.S., P.K.A., D.M.K., Y.S.K.

Drafting the work or revising: S.J.Y.

Final approval of the manuscript: S.J.Y., K.W.M., S.K.G., J.Y.P., V.K.S., P.K.A., D.M.K., Y.S.K., S.H.B.

FUNDING

The study was funded by LG Chem, Ltd., Seoul, Republic of Korea, the manufacturer of gemigliptin.

Acknowledgements
The authors wish to thank all the investigators and patients for their participation in this study. The authors also thank Yoo Hyun Won for medical writing support during the preparation of this manuscript.
Fig. 1.
(A) Mean glycosylated hemoglobin (HbA1c) over time (full analysis set [FAS]). (B) Percentages of responders achieving HbA1c <7% or <6.5% (FAS). pbo-gemi group=placebo→gemigliptin; gemi-gemi group=gemigliptin→gemigliptin. aP<0.0001.
dmj-2020-0047f1.jpg
Table 1.
Summary of changes in efficacy parameters at week 52 from baseline (FAS)
Change from baseline Placebo–gemigliptin group Gemigliptin–gemigliptin group
HbA1c, n 71 80
 Baseline HbA1c, % 8.0±0.8 8.2±0.9
 ∆ from baseline at wk 24 0.0±1.3 –0.6±1.1
  P valuec 0.9492b <0.0001b
 ∆ from baseline at wk 52 –0.7±1.2 –0.9±1.2
  P valuec <0.0001b <0.0001b
 ∆ from wk 24 to 52 –0.7±1.2 –0.3±1.0
  P valuec <0.0001b 0.0971b
FPG, n 71 80
 Baseline FPG, mg/dL 144.3±41.2 152.6±44.2
 ∆ from baseline at wk 24 7.3±52.6 –5.1±81.1
  P valuec 0.3954b 0.0209b
 ∆ from baseline at wk 52 –4.8±51.7 –10.1±54.6
  P valuec 0.5067b 0.0398b
 ∆ from wk 24 to 52 –12.2±59.1 –5.0±67.1
  P valuec 0.0750b 0.6586b
Fasting insulin, n 71 80
 Baseline fasting insulin, µIU/mL 16.7±17.5 14.3±11.1
 ∆ from baseline at wk 24 –4.8±14.8 –0.4±12.6
  P valuec 0.0779b 0.8275b
 ∆ from baseline at wk 52 –5.3±17.1 –2.1±11.8
  P valuec 0.0606b 0.0584b
 ∆ from wk 24 to 52 –0.5±6.6 –1.8±13.0
  P valuec 0.2448b 0.0503b
Fasting proinsulin, n 71 80
 Baseline fasting proinsulin, pM 43.4±68.6 33.5±28.1
 ∆ from baseline at wk 24 –16.0±60.5 1.6±39.0
  P valuec 0.0444b 0.1500b
 ∆ from baseline at wk 52 –16.3±64.4 –7.3±25.3
  P valuec 0.0304b 0.0013b
 ∆ from wk 24 to 52 –0.3±20.07 –8.9±37.7
  P valuec 0.2602b 0.1373b
Fasting C-peptide, n 71 80
 Baseline fasting C-peptide, ng/mL 3.4±2.5 3.4±2.1
 ∆ from baseline at wk 24 –0.7±2.0 –0.3±1.7
  P valuec 0.0010b 0.3720b
 ∆ from baseline at wk 52 –0.5±2.1 –0.2±1.9
  P valuec 0.4051b 0.6250b
 ∆ from wk 24 to 52 0.2±1.4 0.09±1.6
  P valuec 0.0571b 0.1834b
HOMA-β, n 71 80
 Baseline HOMA-β 81.9±73.2 63.8±50.3
 ∆ from baseline at wk 24 –11.6±90.6 4.2±45.4
  P valuec 0.0280b 0.0673b
 ∆ from baseline at wk 52 –7.0±101.2 13.5±125.5
  P valuec 0.4035b 0.7502b
 ∆ from wk 24 to 52 4.6±102.4 9.3±118.5
  P valuec 0.7924b 0.0889b
HOMA-IR, n 71 80
 Baseline HOMA-IR 6.4±8.3 5.8±6.1
 ∆ from baseline at wk 24 –1.9±7.0 0.0±9.4
  P valuec 0.3510b 0.2898b
 ∆ from baseline at wk 52 –2.5±8.2 –1.3±6.8
  P valuec 0.0565b 0.0065b
 ∆ from wk 24 to 52 –0.6±3.7 –1.3±8.9
  P valuec 0.1998b 0.3465b
AUC0–2h glucose, n 13 13
 Baseline AUC0–2h glucose, mg/min/dL 31,484.0±6,454.5 30,135.4±6,051.3
 ∆ from baseline at wk 24 –2,352.7±5,898.4 –3,954.0±4,128.3
  P valuec 0.1760a 0.0006a
 ∆ from baseline at wk 52 –4,782.7±5,760.5 –2,232.3±5,336.8
  P valuec 0.0112a 0.1574a
 ∆ from wk 24 to 52 –2,967.3±3,651.7 2,082.5±5,049.5
  P valuec 0.0225a 0.1468a
AUC0–2h insulin, n 13 13
 Baseline AUC0–2h insulin, µIU/mL 2,109.2±1,028.0 2,498.5±1,734.9
 ∆ from baseline at wk 24 21.1±1,232.1 –525.00±1,311.3
  P valuec 0.7354b 0.4413b
 ∆ from baseline at wk 52 726.4±1,157.2 –252.6±1,208.6
  P valuec 0.0430a 0.4656a
 ∆ from wk 24 to 52 438.1±1,439.8 363.0±1,661.6
  P valuec 0.3367a 0.4285a
AUC0–2h C-peptide, n 13 13
 Baseline AUC0–2h C-peptide, ng/mL 532.2±186.7 588.1±258.3
 ∆ from baseline at wk 24 68.1±161.5 24.8±168.8
  P valuec 0.1545a 0.5306a
 ∆ from baseline at wk 52 142.5±187.1 146.4±145.9
  P valuec 0.0177a 0.0035a
 ∆ from wk 24 to 52 44.6±217.9 70.3±189.2
  P valuec 0.5129a 0.1875a
2-hr glucose, n 13 14
 Baseline 2-hr glucose, mg/dL 279.5±85.9 268.2±87.6
 ∆ from baseline at wk 24 –31.2±78.7 –31.3±54.7
  P valuec 0.1779a 0.0193a
 ∆ from baseline at wk 52 –64.5±77.0 –29.2±80.1
  P valuec 0.0106a 0.1955a
 ∆ from wk 24 to 52 –39.4±65.7 –8.2±55.7
  P valuec 0.0750a 0.5906a
2-hr insulin, n 13 14
 Baseline 2-hr insulin, µIU/mL 17.5±11.6 24.0±19.4
 ∆ from baseline at wk 24 7.0±14.26 –5.0±17.7
  P valuec 0.1021a 0.2186a
 ∆ from baseline at wk 52 15.1±25.0 –0.5±12.1
  P valuec 0.0499a 0.8705a
 ∆ from wk 24 to 52 3.9±28.2 4.7±25.6
  P valuec 0.8311b 0.5021a
2-hr C-peptide, n 13 14
 Baseline 2-hr C-peptide, ng/mL 6.3±2.6 6.3±3.0
 ∆ from baseline at wk 24 0.8±1.1 0.6±2.6
  P valuec 0.0243a 0.2864a
 ∆ from baseline at wk 52 1.5±2.3 1.5±1.5
  P valuec 0.0359a 0.0028a
 ∆ from wk 24 to 52 0.56±2.8 0.2±2.5
  P valuec 0.5211a 0.8240a
GLP-1, n 13 12
 Baseline GLP-1, ng/mL 8.5±5.3 9.7±6.2
 ∆ from baseline at wk 24 11.2±13.4 27.5±53.3
  P valuec 0.0005b 0.0004b
 ∆ from baseline at wk 52 13.8±16.2 21.7±41.9
  P valuec 0.0002b 0.0010b
 ∆ from wk 24 to 52 2.8±14.1 –9.8±23.9
  P valuec 0.2061b 0.1189b
Insulinogenic index, n 17 19
 Baseline insulinogenic index 0.1±0.1 0.1±0.1
 ∆ from baseline at wk 24 0.1±0.2 0.2±0.4
  P valuec 0.0134b 0.0446b
 ∆ from baseline at wk 52 0.1±0.2 –0.1±0.8
  P valuec 0.2114b 0.3525b
 ∆ from wk 24 to 52 –0.0±0.3 –0.3±0.8
  P valuec 0.9460b 0.2412b
Proinsulin to insulin ratio, n 16 20
 Baseline proinsulin to insulin ratio 0.2±0.1 0.4±0.5
 ∆ from baseline at wk 24 0.4±1.1 0.2±0.9
  P valuec 0.3054b 0.8695b
 ∆ from baseline at wk 52 0.1±0.7 –0.1±0.4
  P valuec 0.1354b 0.2774b
 ∆ from wk 24 to 52 –0.3±0.9 –0.2±0.8
  P valuec 0.0803b 0.4631b
DPP-4 inhibition activity, n 71 77
 Wk 24 –3.0±62.6 78.7±52.8
 Wk 52 62.3±77.1 65.2±77.0
Fasting TC, n 71 80
 Baseline fasting TC, mg/dL 159.0±34.0 164.1±43.4
 ∆ from baseline at wk 52 9.0±49.2 5.9±37.1
  P valuec 0.1298a 0.1623a
Fasting HDL, n 71 80
 Baseline fasting HDL, mg/dL 39.4±12.0 38.5±14.3
 ∆ from baseline at wk 52 8.7±12.0 6.4±10.1
  P valuec <0.0001b <0.0001b
Fasting LDL, n 71 80
 Baseline fasting LDL, mg/dL 87.2±30.4 90.2±34.7
 ∆ from baseline at wk 52 12.0±42.4 10.8±33.4
  P valuec 0.0197a 0.0031b
Fasting TG, n 71 80
 Baseline fasting TG, mg/dL 168.5±97.4 187.4±149.4
 ∆ from baseline at wk 52 –28.2±119.2 –40.4±136.8
  P valuec 0.0115b 0.0015b
Body weight, n 71 80
 Baseline body weight, kg 68.0±10.7 67.1±10.1
 ∆ from baseline at wk 52 0.4±2.3 0.4±1.9
  P valuec 0.2183b 0.0909a
Waist circumference, n 71 80
 Baseline waist circumference, cm 91.2±10.5 91.5±11.4
 ∆ from baseline at wk 52 0.0±2.1 0.0±2.4
  P valuec 0.8958b 0.3541b

Values are presented as mean±standard deviation.

FAS, full analysis set; HbA1c, glycosylated hemoglobin; Δ, change; FPG, fasting plasma glucose; HOMA-β, homeostasis model assessment of β-cell function; HOMA-IR, homeostasis model assessment of insulin resistance; AUC, area under the curve; GLP-1, glucagon like peptide-1; DPP-4, dipeptidyl peptidase-4; TC, total cholesterol; HDL, high density lipoprotein; LDL, low density lipoprotein; TG, triglyceride.

a P value obtained from paired t-test,

b P value obtained from Wilcoxon’s signed rank test,

c Intra-comparison.

  • 1. Scheen AJ. A review of gliptins in 2011. Expert Opin Pharmacother 2012;13:81-99.ArticlePubMed
  • 2. Inzucchi SE, Bergenstal RM, Buse JB, Diamant M, Ferrannini E, Nauck M, et al. Management of hyperglycemia in type 2 diabetes: a patient-centered approach: position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care 2012;35:1364-79.ArticlePubMedPMCPDF
  • 3. Craddy P, Palin HJ, Johnson KI. Comparative effectiveness of dipeptidylpeptidase-4 inhibitors in type 2 diabetes: a systematic review and mixed treatment comparison. Diabetes Ther 2014;5:1-41.ArticlePubMedPMCPDF
  • 4. Ahren B. Clinical results of treating type 2 diabetic patients with sitagliptin, vildagliptin or saxagliptin: diabetes control and potential adverse events. Best Pract Res Clin Endocrinol Metab 2009;23:487-98.ArticlePubMed
  • 5. Nauck MA, Vilsboll T, Gallwitz B, Garber A, Madsbad S. Incretin-based therapies: viewpoints on the way to consensus. Diabetes Care 2009;32 Suppl 2:S223-31.PubMed
  • 6. Yang SJ, Min KW, Gupta SK, Park JY, Shivane VK, Pitale SU, et al. A multicentre, multinational, randomized, placebo-controlled, double-blind, phase 3 trial to evaluate the efficacy and safety of gemigliptin (LC15-0444) in patients with type 2 diabetes. Diabetes Obes Metab 2013;15:410-6.ArticlePubMed
  • 7. Monami M, Iacomelli I, Marchionni N, Mannucci E. Dipeptydil peptidase-4 inhibitors in type 2 diabetes: a meta-analysis of randomized clinical trials. Nutr Metab Cardiovasc Dis 2010;20:224-35.ArticlePubMed
  • 8. Richard KR, Shelburne JS, Kirk JK. Tolerability of dipeptidyl peptidase-4 inhibitors: a review. Clin Ther 2011;33:1609-29.ArticlePubMed
  • 9. Amori RE, Lau J, Pittas AG. Efficacy and safety of incretin therapy in type 2 diabetes: systematic review and meta-analysis. JAMA 2007;298:194-206.ArticlePubMed

Figure & Data

References

    Citations

    Citations to this article as recorded by  
    • Efficacy and safety of enavogliflozin versus dapagliflozin added to metformin plus gemigliptin treatment in patients with type 2 diabetes: A double-blind, randomized, comparator-active study: ENHANCE-D study
      Kyung-Soo Kim, Kyung Ah Han, Tae Nyun Kim, Cheol-Young Park, Jung Hwan Park, Sang Yong Kim, Yong Hyun Kim, Kee Ho Song, Eun Seok Kang, Chul Sik Kim, Gwanpyo Koh, Jun Goo Kang, Mi Kyung Kim, Ji Min Han, Nan Hee Kim, Ji Oh Mok, Jae Hyuk Lee, Soo Lim, Sang S
      Diabetes & Metabolism.2023; 49(4): 101440.     CrossRef

    • PubReader PubReader
    • ePub LinkePub Link
    • Cite
      CITE
      export Copy
      Close
      Download Citation
      Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.

      Format:
      • RIS — For EndNote, ProCite, RefWorks, and most other reference management software
      • BibTeX — For JabRef, BibDesk, and other BibTeX-specific software
      Include:
      • Citation for the content below
      A Multicentre, Multinational, Open-Label, 52-Week Extension Study of Gemigliptin (LC15-0444) Monotherapy in Patients with Type 2 Diabetes Mellitus
      Diabetes Metab J. 2021;45(4):606-612.   Published online September 9, 2020
      Close
    • XML DownloadXML Download
    Figure
    Related articles

    Diabetes Metab J : Diabetes & Metabolism Journal