1Clinical Laboratory, The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China
2Xi'an Center for Disease Control and Prevention, Xi'an, China
3Key Laboratory of Biomedical Information Engineering of Ministry of Education, and Biomedical Informatics & Genomics Center, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, China
Copyright © 2021 Korean Diabetes Association
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Characteristic | Discovery GENEVA |
Replication IPM |
||||
---|---|---|---|---|---|---|
Case | Control | Total | Case | Control | Total | |
Sample size | 2,558 | 2,983 | 5,541 | 138 | 565 | 703 |
Male/Female | 1,109/1,449 | 1,275/1,708 | 2,384/3,157 | 101/37 | 370/195 | 471/232 |
Age, yr | 57.36±7.71 | 57.12±7.66 | 57.23±7.69 | 58.71±15.32 | 64.83±10.31 | 59.91±14.67 |
SNP pair | Chr | Position |
Gene |
Allele |
GENEVA |
IPM |
Combined P value |
||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
MAF | CR | OR (95% CI) | P value | MAF | CR | OR (95% CI) | P value | ||||||
rs4947941 | 7 | 54871175 | RP11-745C15.2 | T/C | 0.443 | 1 | 1.00 (0.98–1.02) | 0.824 | 0.424 | 1 | 0.97 (0.92–1.02) | 0.831 | 0.911 |
rs7785013 | 7 | 55152667 | EGFR | A/G | 0.158 | 0.999 | 1.00 (0.98–1.03) | 0.830 | 0.137 | 0.999 | 0.98 (0.91–1.05) | 0.977 | 0.998 |
rs494794×rs7785013 | - | - | - | - | - | - | 0.91 (0.88–0.95) | 9.41×10−7 | - | - | 0.78 (0.70–0.86) | 1.73×10−6 | 4.84×10−10 |
Values are presented as mean±standard deviation. GENEVA, Gene Environment Association Studies initiative in Type 2 Diabetes; IPM, Biobank Program of the Institute of Personalized Medicine.
SNP, single nucleotide polymorphism; Chr, chromosome; GENEVA, Gene Environment Association Studies initiative in Type 2 Diabetes; IPM, Biobank Program of the Institute of Personalized Medicine; MAF, minor allele frequency; CR, call rate; OR, odds ratio; CI, confidence interval; EGFR, epidermal growth factor receptor. Position was relative to the hg19 version of the human genome, The physical location of identified SNP, The former allele represents the minor allele, Meta-analyses results by using two genome-wide association study samples.