Diabetes Metab J > Volume 32(1); 2008 > Article
Korean Diabetes Journal 2008;32(1):10-20.
DOI: https://doi.org/10.4093/kdj.2008.32.1.10    Published online February 1, 2008.
Protective Effects of Lithospermic Acid B on Diabetic Nephropathy in OLETF Rats Comparing with Amlodipine and Losartan.
Eun Seok Kang, Beom Seok Kim, Chul Hoon Kim, Gi Ho Seo, Seung Jin Han, Sung Wan Chun, Kyu Yeon Hur, Chul Woo Ahn, Hunjoo Ha, Mankil Jung, Bong Soo Cha, Hyun Chul Lee
1Division of Endocrinology and Metabolism, Department of Internal Medicine, Yonsei University College of Medicine, Korea.
2Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Korea.
3Institute of Endocrine Research, Yonsei University College of Medicine, Korea.
4Division of Nephrology, Department of Internal Medicine, Yonsei University College of Medicine, Korea.
5Department of Pharmacology, Yonsei University College of Medicine, Korea.
6Ewha Womans University College of Pharmacy and Center for Cell Signaling and Drug Discovery Research, Korea.
7Department of Chemistry, Yonsei University College of Science, Korea.
Abstract
BACKGROUND
Lithospermic acid B (LAB), an active component isolated from Salvia miltiorrhizae, has been reported to have renoprotective effects in type 1 and type 2 diabetic animal models. We examined the effects of LAB on the prevention of diabetic nephropathy compared with amlodipine, a calcium channel blocker, and losartan, an angiotensin receptor blocker, in Otsuka Long-Evans-Tokushima Fatty (OLETF) rats, an animal model of type 2 diabetes. METHODS: LAB (20 mg/kg), amlodipine (10 mg/kg), or losartan (10 mg/kg) was given orally once daily to 10-week-old male OLETF rats for 28 weeks. RESULTS: None of LAB, losartan, and amlodipine exhibited effects on blood glucose levels. Treatment with amlodipine or losartan resulted in similar reductions in blood pressure; however, LAB was less effective in lowering blood pressure. Albuminuria was markedly suppressed by losartan and LAB, but not by amlodipine. LAB treatment decreased levels of renal lipid peroxidation, monocyte chemoattractant protein-1 (MCP-1), and transforming growth factor-beta1 (TGF-beta1). CONCLUSION: These results suggest that LAB has beneficial effects on the diabetic nephropathy in OLETF rats by decreasing oxidative stress and inflammation as potent as losartan.
Key Words: Lithospermic acid B, Amlodipine, Losartan, OLETF rats, Diabetic nephropathy


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