Skip Navigation
Skip to contents

Diabetes Metab J : Diabetes & Metabolism Journal

Search
OPEN ACCESS

Articles

Page Path
HOME > Diabetes Metab J > Volume 33(2); 2009 > Article
Original Article Chronic Complications in Adult Diabetic Patients with and without GAD Antibody.
Jin Ook Chung, Dong Hyeok Cho, Dong Jin Chung, Min Young Chung
Diabetes & Metabolism Journal 2009;33(2):124-133
DOI: https://doi.org/10.4093/kdj.2009.33.2.124
Published online: April 1, 2009
  • 2,339 Views
  • 19 Download
  • 1 Crossref
  • 0 Scopus
Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea. mychung@chonnam.ac.kr
prev next

BACKGROUND
Although the majority of diabetes mellitus (DM) patients diagnosed as adults have non-autoimmune forms of the disease, islet autoimmunity is encountered in some patients initially thought to have type 2 DM. The phenotype of DM patients with glutamic acid decarboxylase (GAD) antibodies is different from that of patients with GAD antibody-negative type 2 DM, with features such as relative leanness and hyperglycemia which may influence the development of complications. We sought to compare the prevalence of chronic complications in patients with and without the GAD antibody. METHODS: We recruited 427 patients (M: 218, F: 209) that were clinically diagnosed with type 2 DM after the age of 35 years. We measured GAD antibody and assessed the factors associated with chronic microvascular and macrovascular complications. RESULTS: Of these patients, 26 were GAD antibody-positive. The patients with GAD antibody had lower systolic blood pressure, higher high-density lipoprotein cholesterol value, and lower level of fasting and stimulated C-peptide than patients without GAD antibody (P < 0.05). Also, the patients with GAD antibody had lower prevalence of retinopathy compared with the patients without GAD antibody (19.2 vs. 47.9%; P < 0.05). The prevalence of nephropathy, peripheral neuropathy and cardiovascular autonomic neuropathy did not differ between the groups. In addition, the prevalence of coronary heart disease, cerebrovascular disease and peripheral arterial disease did not differ between the two groups. CONCLUSION: This study suggests that diabetic patients with GAD antibody have a lower risk for the development of retinopathy compared with patients without GAD antibody.

  • Cite
    CITE
    export Copy
    Close
    Download Citation
    Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.

    Format:
    • RIS — For EndNote, ProCite, RefWorks, and most other reference management software
    • BibTeX — For JabRef, BibDesk, and other BibTeX-specific software
    Include:
    • Citation for the content below
    Chronic Complications in Adult Diabetic Patients with and without GAD Antibody.
    Korean Diabetes J. 2009;33(2):124-133.   Published online April 1, 2009
    Close
Related articles
Chung JO, Cho DH, Chung DJ, Chung MY. Chronic Complications in Adult Diabetic Patients with and without GAD Antibody.. Diabetes Metab J. 2009;33(2):124-133.
DOI: https://doi.org/10.4093/kdj.2009.33.2.124.

Diabetes Metab J : Diabetes & Metabolism Journal
Close layer
TOP