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Original Article The Effect of Gamma-Glutamyltransferase on Impaired Fasting Glucose or Type 2 Diabetes in Korean Men.
Tae Yeon Kim, Do Hoon Kim, Chang Hae Park, Kyung Hwan Cho, Seung Hwan Lee, Hyuk Ga, Hwan cheol Kim
Diabetes & Metabolism Journal 2009;33(3):215-224
DOI: https://doi.org/10.4093/kdj.2009.33.3.215
Published online: June 1, 2009
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1Department of Radiology, Ansan Hospital, Korea University College of Medicine, Ansan, Korea.
2Department of Family Medicine, Anam Hospital, Korea University College of Medicine, Seoul, Korea. daumarong@hanmail.net
3Institute of Geriatric Medicine, Eun-Hye Hospital, Korea.
4Department of Occupational Medicine, Anam Hospital, Inha University College of Medicine, Incheon, Korea.

BACKGROUND
We sought to determine the association between serum gamma-glutamyltransferase (GGT) levels within the normal range and the risk for development of impaired fasting glucose (IFG) or type 2 diabetes. METHODS: This retrospective cohort study spanned four years (2002~2006) with 1,717 Korean men who underwent periodic health examinations at a university hospital in Incheon, Korea and were not diagnosed with IFG or type 2 diabetes. Fasting plasma glucose levels were measured at the annual health examination. IFG and diabetes were defined as a serum fasting glucose concentration of 100~125 mg/dL and more than 126 mg/dL, respectively. Cox's proportional hazards model was used to evaluate the association between serum GGT levels and development of IFG or type 2 diabetes. RESULTS: There was a strong dose-response relationship between serum GGT levels and the incidence of IFG and diabetes. A total of 570 cases (33.2%) of incident IFG and 50 cases (2.9%) of diabetes were found. After controlling potential predictors, the relative risks for the incidence of IFG for GGT levels < or = 19, 20~25, 26~34, 35~50 and > or = 51 were 1.00, 0.99, 1.17, 1.23 and 1.38 respectively (P for trend 0.015), and for the incidence of diabetes were 1.00, 1.44, 1.80, 2.55 and 2.58 respectively (P for trend 0.050). CONCLUSION: The risk for development of IFG and type 2 diabetes increased in a dose-dependent manner as serum GGT increased within its normal range in Korean men.

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    The Effect of Gamma-Glutamyltransferase on Impaired Fasting Glucose or Type 2 Diabetes in Korean Men.
    Korean Diabetes J. 2009;33(3):215-224.   Published online June 1, 2009
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Kim TY, Kim DH, Park CH, Cho KH, Lee SH, Ga H, Kim Hc. The Effect of Gamma-Glutamyltransferase on Impaired Fasting Glucose or Type 2 Diabetes in Korean Men.. Diabetes Metab J. 2009;33(3):215-224.
DOI: https://doi.org/10.4093/kdj.2009.33.3.215.

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