The Association Between Urinary Albumin to Creatinine Ratio and Coronary Artery Calcification in Type 2 Diabetic Patients.

Lee,  Ju Young; Choi,  Yeon Kyung; Seo,  Hyun Ae; Jeon,  Jae Han; Lee,  Jung Eun; Moon,  Seong Su; Kim,  Jung Guk; Kim,  Bo Wan; Lee,  In Kyu

doi:2009.33.4.289

Diabetes Metab J > Volume 33(4); 2009 > Article

Original Article

Korean Diabetes Journal 2009;33(4):289-298.
DOI: https://doi.org/10.4093/kdj.2009.33.4.289 Published online August 1, 2009.

The Association Between Urinary Albumin to Creatinine Ratio and Coronary Artery Calcification in Type 2 Diabetic Patients.

Ju Young Lee, Yeon Kyung Choi, Hyun Ae Seo, Jae Han Jeon, Jung Eun Lee, Seong Su Moon, Jung Guk Kim, Bo Wan Kim, In Kyu Lee

Department of Endocrinology and Metabolism, Kyungpook National University School of Medicine, Daegu, Korea. leei@mail.knu.ac.kr

Abstract

BACKGROUND
Atherosclerosis, the most common cause of death in type 2 diabetic patients, is closely associated with coronary artery calcium deposition. The coronary calcifications can be easily measured using coronary calcium scoring computed tomography (CT). And microalbuminuria is known as an independent risk factor of cardiovascular disease. So, we examined the association of urinary albumin to creatinine ratio (UACR) and coronary calcification score (CCS) in type 2 diabetic patients. METHODS: Among type 2 diabetic patients who underwent the multidetector CT scanning for the evaluation of CCS at Kyungpook National University Hospital between December 2007 and May 2008, 155 subjects were included. CCS, demographic and laboratory data were assessed. RESULTS: Coronary artery calcifications were identified in 90 patients (51%) and mean, median CCS was 205.8 +/- 476.9, 8.74 (0, 132.0). 60 subjects revealed UACR greater than 30 ug/mg. With the UACR increment, CCS revealed a significant increase (P < 0.001). Age, duration of diabetes, serum Apo A1 level, serum high sensitivity C-reactive protein (hs-CRP) level were also associated with CCS. However, after adjusting for age, UACR and CCS exhibited a significant positive relationship (P = 0.002). CONCLUSION: Increased UACR is associated with coronary artery calcification in type 2 diabetic patients and these results will be useful in early evaluating the presence of macrovascular complications in these patients.

Key Words: Albuminuria, Coronary artery disease, Type 2 diabetes mellitus