Clinical Implications of Serum Biomarkers in Diabetic Cardiovascular Complications.

Son,  Jang Won; Kwon,  Hyuk Sang

doi:2009.33.5.363

Diabetes Metab J > Volume 33(5); 2009 > Article

Review

Korean Diabetes Journal 2009;33(5):363-372.
DOI: https://doi.org/10.4093/kdj.2009.33.5.363 Published online October 1, 2009.

Clinical Implications of Serum Biomarkers in Diabetic Cardiovascular Complications.

Jang Won Son, Hyuk Sang Kwon

Department of Internal Medicine, The Catholic University of Korea, Seoul, Korea.

Abstract

Diabetes is associated with increased risk of cardiovascular disease, with atherosclerosis responsible for most associated morbidity and mortality. Atherosclerosis often causes acute thrombotic events through plaque rupture and formation of platelet-rich thrombi. The principal clinical manifestations of atherosclerosis are coronary artery disease, ischemic stroke, and peripheral arterial disease. Endothelial dysfunction, oxidative stress, and low-grade inflammation are key features in the pathophysiology of atherosclerosis.

Key Words: Atherosclerosis, Biological markers, Cardiovascular disease, Diabetes mellitus