Skip Navigation
Skip to contents

Diabetes Metab J : Diabetes & Metabolism Journal

Search
OPEN ACCESS

Articles

Page Path
HOME > Diabetes Metab J > Volume 22(4); 1998 > Article
Original Article Serum Levels of Transforming Growth Factor ( TGF ) -beta1 in Type 2 Diabetic Patients.
Nan Hee Kim, Jung Heon Oh, Young Hyun Kim, Ie Byung Park, Sang Jin Kim, Sei Hyun Baik, Dong Seop Choi
Diabetes & Metabolism Journal 1998;22(4):522-530
DOI: https://doi.org/
Published online: January 1, 2001
  • 998 Views
  • 20 Download
  • 0 Crossref
  • 0 Scopus

BACKGROUND
Transforming growth factor(TGF)-Bl is a potent inducer of extracellular matrix production and of fibrogenesis and has been associated wnh the occurrence of diabetic complications. Our aim was to determine whether circulating levels of TGF-gl are altered in type 2 DM and, if so, whether they are correlated with blorxi glucose levels and show an association with diabetic complications. METHOD: Serum levels of TGF-gl were measured by quantitative sandwitch enzyme immunoassay in 76 type 2 DM patients and were correlated with clinical and biochemical parameters and the presence of diabetic complications. Result: 1) Serum TGF-B1 levels were correlated with fasting blood glucose levels (r=0.30, p=0.007) and inversely correlated with duration of diabetes (r=-0.31, p=0.007), BUN (r=-0.31, p=0.034), and creatinine (r=-0.40, p=0.004). In linear logistic regression analysis, duration of diabetes and HbA 1C <- were independently related to serum TGF-B1 levels. 2) Serum levels of TGF-B1 were significantly decreased in proteinuria group (n=23) than in normoalbuminuria group (n=26) (69.5+27.5 vs 85.7 +23 ng/mL, p=0.022). TGF-B1 concentrations were inversely correlated with serum creatinine and age in normoalbuminuria group (r=-0.40, p

  • Cite
    CITE
    export Copy
    Close
    Download Citation
    Download a citation file in RIS format that can be imported by all major citation management software, including EndNote, ProCite, RefWorks, and Reference Manager.

    Format:
    • RIS — For EndNote, ProCite, RefWorks, and most other reference management software
    • BibTeX — For JabRef, BibDesk, and other BibTeX-specific software
    Include:
    • Citation for the content below
    Serum Levels of Transforming Growth Factor ( TGF ) -beta1 in Type 2 Diabetic Patients.
    Korean Diabetes J. 1998;22(4):522-530.   Published online January 1, 2001
    Close
Related articles
Kim NH, Oh JH, Kim YH, Park IB, Kim SJ, Baik SH, Choi DS. Serum Levels of Transforming Growth Factor ( TGF ) -beta1 in Type 2 Diabetic Patients.. Diabetes Metab J. 1998;22(4):522-530.
DOI: https://doi.org/.

Diabetes Metab J : Diabetes & Metabolism Journal