Diabetes Metab J > Volume 30(4); 2006 > Article
Korean Diabetes Journal 2006;30(4):285-291.
DOI: https://doi.org/10.4093/jkda.2006.30.4.285    Published online July 1, 2006.
Prevalence of Metabolic Syndrome in Young Korean Women with Polycystic Ovary Syndrome.
Hyejin Lee, Jee Young Oh, Youngsun Hong, Yeon Ah Sung, Hyewon Chung
1Department of Internal Medicine, Ewha Womans University College of Medicine, Korea.
2Department of Obstetrics and Gynecology, Ewha Womans University College of Medicine, Korea.
Polycystic ovary syndrome (PCOS) is characterized by insulin resistance and consequent hyperinsulinemia. Insulin resistance plays an important role in the development of metabolic syndrome (MS). We conducted a cross-sectional study to determine the prevalence of the MS and whether the insulin resistance or hyperandrogenemia is related to the MS in young Korean women with PCOS. METHODS: 143 women with PCOS (mean age 26+/-5 years) were studied to evaluate the prevalence of MS by modified Adult Treatment Panel III. Insulin sensitivity was evaluated by euglycemic hyperinsulinemic clamp technique. RESULTS: The prevalence of MS in women with PCOS was 11.9%, 2.8-fold higher than age matched women in Korean urban population. The most frequent component of MS was low HDL cholesterol (39.4%), and the least frequent one was high fasting serum glucose levels (6.7%). The frequency of MS was 40.7% in obese PCOS (BMI > or = 25 kg/m2, n = 38), 10.0% in overweight PCOS (BMI 23~24.9 kg/m2, n = 13), and 0% in lean PCOS (BMI < 23 kg/m2, n = 92). The frequency of MS was 26.1% in insulin resistant PCOS (insulin mediated glucose uptake, IMGU < lowest 10th percentile of lean controls, n = 65), whereas no one had MS in insulin sensitive PCOS (IMGU > or = lowest 10th percentile of lean controls, n = 78). CONCLUSION: MS is frequent in young women with PCOS, and obesity and insulin resistance might be essential for the development of MS in this study group.
Key Words: Metabolic syndrome, PCOS

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