Diabetes Metab J > Volume 30(3); 2006 > Article
Korean Diabetes Journal 2006;30(3):207-216.
DOI: https://doi.org/10.4093/jkda.2006.30.3.207    Published online May 1, 2006.
The Relationship between Visceral & Subcutaneous Fat and Small Dense Low Density Lipoprotein Cholesterol Concentration in Type 2 Diabetic Patients.
Wan Sub Shim, Soo Kyung Kim, Hae Jin Kim, Eun Seok Kang, Chul Woo Ahn, Sung Kil Lim, Hyun Chul Lee, Bong Soo Cha
1Department of Internal Medicine, Inha University College of Medicine, Korea.
2Department of Internal Medicine, College of Medicine, Pochon CHA University, Korea.
3Department of Endocrinology and Metabolism, Ajou Univerisity School of Medicine, Korea.
4Department of Internal Medicine, Yonsei University College of Medicine, Korea.
5Institute of Endocrine Research, Yonsei University College of Medicine, korea.
Abstract
BACKGROUND
Visceral obesity is closely associated with cardiovascular disease (CVD). Small dense (sd) LDL is closely associated with CVD. The aim of this study was to evaluate the relationship between visceral and subcutaneous fat accumulation and sd LDL-C concentration. METHODS: 264 type 2 diabetic patients underwent ultrasonography to estimate visceral & subcutaneous fat accumulation and sd LDL-C concentrations were measured. RESULTS: BMI, total cholesterol, sd LDL-C concentration and percentage of sd LDL-C were higher in highest tertile of visceral fat length in male than those in lowest tertile. BMI, total cholesterol, triglyceride, LDL-C, sd LDL-C concentration and percentage of sd LDL-C were higher in highest tertile of visceral fat length in female than those in lowest tertile. But sd LDL-C concentration and percentage of sd LDL-C were not different among three groups based on the tertile of subcutaneous fat length in male and female. Visceral fat length was correlated with sd LDL-C concentration and percentage of sd LDL-C, total cholesterol, triglyceride, LDL-C, but negatively with percentage of large buoyant LDL-C and HDL-C after adjustment of age, sex and BMI. Subcutaneous fat length was not correlated with sd LDL-C and percentage of sd LDL-C, total cholesterol, triglyceride, HDL-C and LDL-C. CONCLUSION: The association between visceral fat length and sd LDL-C could be a factor that explains the association between visceral obesity and CVD.
Key Words: Small dense LDL-C, Subcutaneous fat, Type 2 diabetes mellitus, Ultrasonography, Visceral fat


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