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Pyruvate Dehydrogenase Kinases: Therapeutic Targets for Diabetes and Cancers |
Nam Ho Jeoung |
Diabetes Metab J. 2015;39(3):188-197. Published online June 15, 2015 DOI: https://doi.org/10.4093/dmj.2015.39.3.188 |
Pyruvate Dehydrogenase Kinases: Therapeutic Targets for Diabetes and Cancers Loss of metabolic flexibility as a result of overexpression of pyruvate dehydrogenase kinases in muscle, liver and the immune system: Therapeutic targets in metabolic diseases Src Family Kinases as Therapeutic Targets in Advanced Solid Tumors: What We Have Learned So Far Genetic Inactivation of Pyruvate Dehydrogenase Kinases Improves Hepatic Insulin Resistance Induced Diabetes The pyruvate dehydrogenase complex as a therapeutic target for age-related diseases Therapeutic Targeting of the Pyruvate Dehydrogenase Complex/Pyruvate Dehydrogenase Kinase (PDC/PDK) Axis in Cancer Molecular Signaling Pathways and Therapeutic Targets in Hepatocellular Carcinoma Therapeutic targeting of the pyruvate dehydrogenase complex/pyruvate dehydrogenase kinase (PDC/PDK) axis for congenital and acquired metabolic diseases Pyruvate dehydrogenase kinases (PDKs): an overview toward clinical applications Integrins as Therapeutic Targets: Successes and Cancers |