Pathophysiology of Diabetic Retinopathy: The Old and the New
Sentaro Kusuhara (Kusuhara S), Yoko Fukushima (Fukushima Y), Shuntaro Ogura (Ogura S), Naomi Inoue (Inoue N), Akiyoshi Uemura (Uemura A)
Diabetes Metab J. 2018;42(5):364-376.   Published online 2018 Oct 22     DOI: https://doi.org/10.4093/dmj.2018.0182
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Benjamin G. Spencer, Jose J. Estevez, Ebony Liu, Jamie E. Craig, John W. Finnie
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Kota Sato, Seiya Mochida, Daisuke Tomimoto, Takahiro Konuma, Naoki Kiyota, Satoru Tsuda, Yukihiro Shiga, Kazuko Omodaka, Toru Nakazawa
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Maha Coucha, Amy C. Barrett, Joseph Bailey, Maryam Abdelghani, Mohammed Abdelsaid
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Rheumatology.2020; 59(8): 2005.     CrossRef
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International Journal of Molecular Sciences.2020; 21(6): 2158.     CrossRef
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FASEB BioAdvances.2020; 2(10): 613.     CrossRef
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Ocular Immunology and Inflammation.2020; : 1.     CrossRef
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Rute S. Araújo, Diogo B. Bitoque, Gabriela A. Silva
Molecular Therapy - Nucleic Acids.2020; 22: 329.     CrossRef
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Songtao Yang, Jiaoyue Zhang, Lulu Chen
Biomedicine & Pharmacotherapy.2020; 132: 110818.     CrossRef
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Hsin-Yi Chen, Yi-Jung Ho, Hsiu-Chuan Chou, En-Chi Liao, Yi-Ting Tsai, Yu-Shan Wei, Li-Hsun Lin, Meng-Wei Lin, Yi-Shiuan Wang, Mei-Lan Ko, Hong-Lin Chan
International Journal of Molecular Sciences.2020; 21(18): 6482.     CrossRef
Circadian rhythms in diabetic retinopathy: an overview of pathogenesis and investigational drugs
Ashay D. Bhatwadekar, Varun Rameswara
Expert Opinion on Investigational Drugs.2020; 29(12): 1431.     CrossRef
Blood-retinal barrier as a converging pivot in understanding the initiation and development of retinal diseases
Xue Yang, Xiao-Wei Yu, Dan-Dan Zhang, Zhi-Gang Fan
Chinese Medical Journal.2020; 133(21): 2586.     CrossRef
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Liyang Ji, Li Li, Ying Zhao, Shengqiang Liu, Jingmin Li, Jinsong Zhang, Qi Zhao, Shuai Wang
Investigative Opthalmology & Visual Science.2020; 61(14): 30.     CrossRef
Dipeptidyl Peptidase-4 Inhibitors versus Other Antidiabetic Drugs Added to Metformin Monotherapy in Diabetic Retinopathy Progression: A Real World-Based Cohort Study
Yoo-Ri Chung, Kyoung Hwa Ha, Hyeon Chang Kim, Sang Jun Park, Kihwang Lee, Dae Jung Kim
Diabetes & Metabolism Journal.2019; 43(5): 640.     CrossRef
Age-related changes of the human retinal vessels: Possible involvement of lipid peroxidation
Tapas Chandra Nag, Meenakshi Maurya, Tara Sankar Roy
Annals of Anatomy - Anatomischer Anzeiger.2019; 226: 35.     CrossRef
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Kachamakova-Trojanowska, Stepniewski, Dulak
Cells.2019; 8(11): 1440.     CrossRef
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Journal of Clinical Medicine.2019; 8(12): 2217.     CrossRef
RANKL blockade suppresses pathological angiogenesis and vascular leakage in ischemic retinopathy
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Biochemical and Biophysical Research Communications.2019; 516(2): 350.     CrossRef
Endogenous Clostridium perfringens Panophthalmitis with Potential Entry Port from Diverticulitis Exacerbated by Proliferative Diabetic Retinopathy
Vamsee Neerukonda, Anny M. S. Cheng, Swetha Dhanireddy, Samuel Alpert, Han Y. Yin
Case Reports in Ophthalmological Medicine.2019; 2019: 1.     CrossRef
Attenuation of Retinal Endothelial Vasodilator Function in a Rat Model of Retinopathy of Prematurity
Ayuki Nakano, Asami Mori, Shiho Arima, Daiki Asano, Akane Morita, Kenji Sakamoto, Tohru Nagamitsu, Tsutomu Nakahara
Current Eye Research.2019; 44(12): 1360.     CrossRef
Efficacy of fenofibrate for diabetic retinopathy
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Medicine.2019; 98(14): e14999.     CrossRef
Nutraceuticals for the Treatment of Diabetic Retinopathy
Maria Grazia Rossino, Giovanni Casini
Nutrients.2019; 11(4): 771.     CrossRef
Efficacy of ranibizumab for the treatment of diabetic retinopathy
Yong-bo Ren, Xing-jie Su, Yan-xiu Qi, He-qun Luan, Qi Sun
Medicine.2019; 98(17): e15409.     CrossRef