Pyruvate Dehydrogenase Kinases: Therapeutic Targets for Diabetes and Cancers
Nam Ho Jeoung (Jeoung NH)
Diabetes Metab J. 2015;39(3):188-197.   Published online 2015 Jun 15     DOI: https://doi.org/10.4093/dmj.2015.39.3.188
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Developmental Cell.2021; 56(8): 1182.     CrossRef
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Long non-coding RNA AFAP1-AS1 facilitates ovarian cancer progression by regulating the miR-107/PDK4 axis
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circ_0005962 functions as an oncogene to aggravate NSCLC progression
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Aging.2021; 13(17): 21155.     CrossRef
Circular RNA circ-ERBB2 Elevates the Warburg Effect and Facilitates Triple-Negative Breast Cancer Growth by the MicroRNA 136-5p/Pyruvate Dehydrogenase Kinase 4 Axis
Yihong Huang, Shuo Zheng, Ying Lin, Liming Ke
Molecular and Cellular Biology.2021;[Epub]     CrossRef
Odontogenic gene expression profile of human dental pulp-derived cells under high glucose influence: a microarray analysis
Sivaporn HORSOPHONPHONG, Hathaitip SRITANAUDOMCHAI, Siriruk NAKORNCHAI, Nakarin KITKUMTHORN, Rudee SURARIT
Journal of Applied Oral Science.2021;[Epub]     CrossRef
Dihydrolipoamide dehydrogenase, pyruvate oxidation, and acetylation-dependent mechanisms intersecting drug iatrogenesis
I. F. Duarte, J. Caio, M. F. Moedas, L. A. Rodrigues, A. P. Leandro, I. A. Rivera, M. F. B. Silva
Cellular and Molecular Life Sciences.2021; 78(23): 7451.     CrossRef
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International Journal of Molecular Sciences.2020; 21(17): 6021.     CrossRef
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Conditional knockout of pyruvate dehydrogenase in mouse pancreatic β‑cells causes morphological and functional changes
Xiao Wang, Shuchang Lai, Yanshi Ye, Yuanyuan Hu, Daoyan Pan, Xiaochun Bai, Jie Shen
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STAT 3 ‐dependent analysis reveals PDK 4 as independent predictor of recurrence in prostate cancer
Monika Oberhuber, Matteo Pecoraro, Mate Rusz, Georg Oberhuber, Maritta Wieselberg, Peter Haslinger, Elisabeth Gurnhofer, Michaela Schlederer, Tanja Limberger, Sabine Lagger, Jan Pencik, Petra Kodajova, Sandra Högler, Georg Stockmaier, Sandra Grund‐Gröschk
Molecular Systems Biology.2020;[Epub]     CrossRef
Differential effects of metformin on reductive activity and energy production in pituitary tumor cells compared to myogenic precursors
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Endocrine.2020; 69(3): 604.     CrossRef
Advanced glycation end products enhance macrophage polarization to the M1 phenotype via the HIF-1α/PDK4 pathway
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Molecular and Cellular Endocrinology.2020; 514: 110878.     CrossRef
Effects of octreotide on autophagy markers and cell viability markers related to metabolic activity in rat pituitary tumor cells
Giovanni Tulipano, Andrea Giustina
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Tamara Fernández-Calero, Marcos Davyt, Karen Perelmuter, Cora Chalar, Giovana Bampi, Helena Persson, Juan Pablo Tosar, Völundur Hafstað, Hugo Naya, Carlos Rovira, Mariela Bollati-Fogolín, Ricardo Ehrlich, Gilles Flouriot, Zoya Ignatova, Mónica Marín
Cancer & Metabolism.2020;[Epub]     CrossRef
miR-16-5p/PDK4-Mediated Metabolic Reprogramming Is Involved in Chemoresistance of Cervical Cancer
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Molecular Therapy - Oncolytics.2020; 17: 509.     CrossRef
Bayesian variable selection for high dimensional predictors and self-reported outcomes
Xiangdong Gu, Mahlet G Tadesse, Andrea S Foulkes, Yunsheng Ma, Raji Balasubramanian
BMC Medical Informatics and Decision Making.2020;[Epub]     CrossRef
Epigenetic Regulation of Pulmonary Arterial Hypertension-Induced Vascular and Right Ventricular Remodeling: New Opportunities?
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International Journal of Molecular Sciences.2020; 21(23): 8901.     CrossRef
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Impaired skeletal muscle mitochondrial pyruvate uptake rewires glucose metabolism to drive whole-body leanness
Arpit Sharma, Lalita Oonthonpan, Ryan D Sheldon, Adam J Rauckhorst, Zhiyong Zhu, Sean C Tompkins, Kevin Cho, Wojciech J Grzesik, Lawrence R Gray, Diego A Scerbo, Alvin D Pewa, Emily M Cushing, Michael C Dyle, James E Cox, Chris Adams, Brandon S Davies, Ri
eLife.2019;[Epub]     CrossRef
Restoring mitochondrial biogenesis with metformin attenuates β-GP-induced phenotypic transformation of VSMCs into an osteogenic phenotype via inhibition of PDK4/oxidative stress-mediated apoptosis
Wen-Qi Ma, Xue-Jiao Sun, Ying Wang, Yi Zhu, Xi-Qiong Han, Nai-Feng Liu
Molecular and Cellular Endocrinology.2019; 479: 39.     CrossRef
Effects of intermittent hypoxia training on leukocyte pyruvate dehydrogenase kinase 1 (PDK-1) mRNA expression and blood insulin level in prediabetes patients
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European Journal of Applied Physiology.2019; 119(3): 813.     CrossRef
Increased pyruvate dehydrogenase activity in skeletal muscle of growth-restricted ovine fetuses
Alexander L. Pendleton, Laurel R. Humphreys, Melissa A. Davis, Leticia E. Camacho, Miranda J. Anderson, Sean W. Limesand
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology.2019; 317(4): R513.     CrossRef
Insulin induces phosphorylation of pyruvate dehydrogenase through RhoA activation pathway in HepG2 cells
Rokibul Islam, Jae-Gyu Kim, Yohan Park, Jung-Yoon Cho, Kim-Cuong Cap, A-Ra Kho, Won-Suk Chung, Sang-Won Suh, Jae-Bong Park
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ATP produced by anaerobic glycolysis is essential for enucleation of human erythroblasts
Tatsufumi Goto, Kumi Ubukawa, Isuzu Kobayashi, Kotomi Sugawara, Ken Asanuma, Yumi Sasaki, Yong-Mei Guo, Naoto Takahashi, Kenichi Sawada, Hideki Wakui, Wataru Nunomura
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Andreia S.P. Pereira, Helena den Haan, Jorge Peña-García, Marién M. Moreno, Horacio Pérez-Sánchez, Zeno Apostolides
Molecules.2019; 24(10): 2002.     CrossRef
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Andreia S.P. Pereira, Antonio J. Banegas-Luna, Jorge Peña-García, Horacio Pérez-Sánchez, Zeno Apostolides
Molecules.2019; 24(22): 4030.     CrossRef
Myocardial Adaptation in Pseudohypoxia: Signaling and Regulation of mPTP via Mitochondrial Connexin 43 and Cardiolipin
Miroslav Ferko, Natália Andelová, Barbara Szeiffová Bačová, Magdaléna Jašová
Cells.2019; 8(11): 1449.     CrossRef
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Maja Dembic, Henriette S. Andersen, Jean Bastin, Thomas K. Doktor, Thomas J. Corydon, Jörn Oliver Sass, Alexandra Lopes Costa, Fatima Djouadi, Brage S. Andresen
Molecular Genetics and Metabolism.2019; 126(1): 64.     CrossRef
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Matthew T. Andrews
Journal of Experimental Biology.2019;[Epub]     CrossRef
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Surangkana Sanmai, Tanakorn Proungvitaya, Temduang Limpaiboon, Daraporn Chua‑On, Wunchana Seubwai, Sittiruk Roytrakul, Sopit Wongkham, Chaisiri Wongkham, Ongart Somintara, Sakkarn Sangkhamanon, Siriporn Proungvitaya
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RSC Advances.2019; 9(61): 35760.     CrossRef
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F Peng, J-H Wang, W-J Fan, Y-T Meng, M-M Li, T-T Li, B Cui, H-F Wang, Y Zhao, F An, T Guo, X-F Liu, L Zhang, L Lv, D-K Lv, L-Z Xu, J-J Xie, W-X Lin, E W-F Lam, J Xu, Q Liu
Oncogene.2018; 37(8): 1062.     CrossRef
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Lise Van Wyngene, Jolien Vandewalle, Claude Libert
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Li Zhou, Mu-Lu Zhan, Yi Tang, Ming Xiao, Ming Li, Qing-Shu Li, Lian Yang, Xian Li, Wen-Wen Chen, Ya-Lan Wang
International Journal of Oncology.2018;[Epub]     CrossRef
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Bo-Yoon Park, Jae-Han Jeon, Younghoon Go, Hye Jin Ham, Jeong-Eun Kim, Eun Kyung Yoo, Woong Hee Kwon, Nam-Ho Jeoung, Yong Hyun Jeon, Seung-Hoi Koo, Byung-Gyu Kim, Ling He, Keun-Gyu Park, Robert A. Harris, In-Kyu Lee
Diabetes.2018; 67(10): 2054.     CrossRef
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Bojana Ristic, Yangzom D. Bhutia, Vadivel Ganapathy
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer.2017; 1868(1): 246.     CrossRef
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Wen-Qi Ma, Xi-Qiong Han, Ying Wang, Xin Wang, Yi Zhu, Nai-Feng Liu
Oncotarget.2017; 8(68): 112841.     CrossRef
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Tae-Wook Chung, Jung Hee Lee, Hee-Jung Choi, Mi-Ju Park, Eun-Yeong Kim, Jung Ho Han, Se Bok Jang, Syng-Ook Lee, Sang Woo Lee, Jin Hang, Li Wan Yi, Ki-Tae Ha
Journal of Ethnopharmacology.2017; 203: 47.     CrossRef
Spatial Organization of Metabolic Enzyme Complexes in Cells
Danielle L. Schmitt, Songon An
Biochemistry.2017; 56(25): 3184.     CrossRef
Dicumarol inhibits PDK1 and targets multiple malignant behaviors of ovarian cancer cells
Wenjia Zhang, Jing Su, Huadan Xu, Shanshan Yu, Yanan Liu, Yong Zhang, Liankun Sun, Ying Yue, Xiaoli Zhou, Aamir Ahmad
PLOS ONE.2017; 12(6): e0179672.     CrossRef
Metabonomic Strategy for the Evaluation of Chinese Medicine Salvia miltiorrhiza and Dalbergia odorifera Interfering with Myocardial Ischemia/Reperfusion Injury in Rats
Fei Mu, Jialin Duan, Haixu Bian, Xiaohu Zhai, Peijin Shang, Rui Lin, Meina Zhao, Dongmei Hu, Ying Yin, Aidong Wen, Miaomiao Xi
Rejuvenation Research.2017; 20(4): 263.     CrossRef
Regulation of pyruvate dehydrogenase (PDH) in the hibernating ground squirrel, ( Ictidomys tridecemlineatus )
Sanoji Wijenayake, Shannon N. Tessier, Kenneth B. Storey
Journal of Thermal Biology.2017; 69: 199.     CrossRef
Nuclear localization of metabolic enzymes in immunity and metastasis
Yuchen He, Menghui Gao, Yiqu Cao, Haosheng Tang, Shuang Liu, Yongguang Tao
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer.2017; 1868(2): 359.     CrossRef
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Ewa Jablonska, Edyta Reszka, Jolanta Gromadzinska, Edyta Wieczorek, Magdalena Krol, Sara Raimondi, Katarzyna Socha, Maria Borawska, Wojciech Wasowicz
Nutrients.2016; 8(12): 772.     CrossRef
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Jaechan Leem, In-Kyu Lee
Endocrinology and Metabolism.2016; 31(1): 52.     CrossRef
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Gwon-Soo Jung, Jae-Han Jeon, Yeon-Kyung Choi, Se Young Jang, Soo Young Park, Sung-Woo Kim, Jun-Kyu Byun, Mi-Kyung Kim, Sungwoo Lee, Eui-Cheol Shin, In-Kyu Lee, Yu Na Kang, Keun-Gyu Park
Scientific Reports.2016;[Epub]     CrossRef
Drugs that Affect Cardiac Metabolism: Focus on Perhexiline
Cher-Rin Chong, Benedetta Sallustio, John D. Horowitz
Cardiovascular Drugs and Therapy.2016; 30(4): 399.     CrossRef
Computational Study on New Natural Compound Inhibitors of Pyruvate Dehydrogenase Kinases
Xiaoli Zhou, Shanshan Yu, Jing Su, Liankun Sun
International Journal of Molecular Sciences.2016; 17(3): 340.     CrossRef
Metabolic Plasticity as a Determinant of Tumor Growth and Metastasis
Camille Lehuédé, Fanny Dupuy, Rebecca Rabinovitch, Russell G. Jones, Peter M. Siegel
Cancer Research.2016; 76(18): 5201.     CrossRef