Diabetic Cardiomyopathy and Its Prevention by Nrf2: Current Status
Jing Chen (Chen J), Zhiguo Zhang (Zhang Z), Lu Cai (Cai L)
Diabetes Metab J. 2014;38(5):337-345.   Published online 2014 Oct 17     DOI: https://doi.org/10.4093/dmj.2014.38.5.337
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Cell Death & Disease.2017; 8(3): e2690.     CrossRef
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Diabetes.2017; 66(10): 2681.     CrossRef
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Yong Li, Xiao-Li Wang, Xiaojing Sun, Qiang Chai, Jingchao Li, Benjamin Thompson, Win-Kuang Shen, Tong Lu, Hon-Chi Lee
Diabetes and Vascular Disease Research.2017; 14(4): 353.     CrossRef
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Diabetes.2017; 66(2): 529.     CrossRef
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Minji Woo, Mijeong Kim, Jeong Sook Noh, Yeong Ok Song
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Phiwayinkosi Dludla, Christo Muller, Elizabeth Joubert, Johan Louw, M. Essop, Kwazi Gabuza, Samira Ghoor, Barbara Huisamen, Rabia Johnson
Molecules.2017; 22(1): 129.     CrossRef
Intermittent hypoxia-induced cardiomyopathy and its prevention by Nrf2 and metallothionein
Shanshan Zhou, Xia Yin, Jingpeng Jin, Yi Tan, Daniel J. Conklin, Ying Xin, Zhiguo Zhang, Weixia Sun, Taixing Cui, Jun Cai, Yang Zheng, Lu Cai
Free Radical Biology and Medicine.2017; 112: 224.     CrossRef
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Ya-Yu Chen, Chia-Fang Tsai, Ming-Chu Tsai, Yu-Wen Hsu, Fung-Jou Lu
Experimental Eye Research.2017; 160: 96.     CrossRef
Ischemia reperfusion injury, ischemic conditioning and diabetes mellitus
Anne Lejay, Fei Fang, Rohan John, Julie A.D. Van, Meredith Barr, Fabien Thaveau, Nabil Chakfe, Bernard Geny, James W. Scholey
Journal of Molecular and Cellular Cardiology.2016; 91: 11.     CrossRef
The Role of the Nrf2/ARE Antioxidant System in Preventing Cardiovascular Diseases
Robert Smith, Kevin Tran, Cynthia Smith, Miranda McDonald, Pushkar Shejwalkar, Kenji Hara
Diseases.2016; 4(4): 34.     CrossRef
Prohibitin overexpression improves myocardial function in diabetic cardiomyopathy
Wen-qian Dong, Min Chao, Qing-hua Lu, Wei-li Chai, Wei Zhang, Xue-ying Chen, Er-shun Liang, Ling-bo Wang, Hong-liang Tian, Yu-guo Chen, Ming-xiang Zhang
Oncotarget.2016; 7(1): 66.     CrossRef
Restoration of Nrf2 Signaling Normalizes the Regenerative Niche
Marc A. Soares, Oriana D. Cohen, Yee Cheng Low, Rita A. Sartor, Trevor Ellison, Utkarsh Anil, Lavinia Anzai, Jessica B. Chang, Pierre B. Saadeh, Piul S. Rabbani, Daniel J. Ceradini
Diabetes.2016; 65(3): 633.     CrossRef
Myocardial transcription factors in diastolic dysfunction: clues for model systems and disease
Alexander T. Mikhailov, Mario Torrado
Heart Failure Reviews.2016; 21(6): 783.     CrossRef
Antioxidant Properties of Whole Body Periodic Acceleration (pGz)
Arkady Uryash, Jorge Bassuk, Paul Kurlansky, Francisco Altamirano, Jose R. Lopez, Jose A. Adams, Guillermo López Lluch
PLOS ONE.2015; 10(7): e0131392.     CrossRef
Mulberry leaves (Morus alba L.) ameliorate obesity-induced hepatic lipogenesis, fibrosis, and oxidative stress in high-fat diet-fed mice
Ji-Young Ann, Hyeyoon Eo, Yunsook Lim
Genes & Nutrition.2015;[Epub]     CrossRef
Oxidative Stress and Human Hypertension: Vascular Mechanisms, Biomarkers, and Novel Therapies
Augusto C. Montezano, Maria Dulak-Lis, Sofia Tsiropoulou, Adam Harvey, Ana M. Briones, Rhian M. Touyz
Canadian Journal of Cardiology.2015; 31(5): 631.     CrossRef
Haeme oxygenase signalling pathway: implications for cardiovascular disease
Laura E. Fredenburgh, Allison A. Merz, Susan Cheng
European Heart Journal.2015; 36(24): 1512.     CrossRef